Dr Briony Gliddon

Research Fellow Centre for Cancer Biology

City West Campus (HB10-27)
tel +61 8 830 27895

email Briony.Gliddon@unisa.edu.au

Research

Research focus

Clinical Sciences
Biochemistry and Cell Biology
Biological Sciences
Cardiovascular Medicine and Haematology
Medical Physiology

Research

Projects

Excludes commercial-in-confidence projects.

Harnessing an unexpected new role of the CD47:SPRPA axis to target glioblastome invasion, NHMRC - Ideas Grants, 01/01/2024 - 31/12/2027
Overcoming the blood-brain barrier for improved brain tumour therapy, Fay Fuller Foundation, 01/07/2024 - 30/06/2027
Understanding the biology of treatment resistant brain tumours so that new therapeutic approaches can be developed, Neurosurgical Research Foundation, 04/07/2024 - 31/12/2025
A new therapeutic approach for glioblastoma, Brain Foundation - Annual Research Awards, 01/01/2025 - 31/12/2025
New approaches to enhance immunotherapy for brain tumours, NHMRC - Ideas Grants, 01/01/2023 - 25/12/2025
Targeting sphingosine kinase 1 as a novel therapeutic strategy in childhood medulloblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Combined targeting of CD47 and cysteine metabolism to treat glioblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Pre-clinical evaluation of sphingosine kinase 2 inhibitors as new glioblastoma therapeutics, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Harnessing S1P receptor 1 to enhance CAR-T cell immunotherapy, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Developing clinically relevant models of recurrent glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Targeting cyclin-dependent kinase 4 in glioblastoma, Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Li, M, Bennett, MK, Toubia, J, Pope, VS, Tea, MN, Tamang, S, Samuel, MS, Anderson, PH, Gliddon, BL, Powell, JA & Pitson, SM 2024, 'An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma', British Journal of Haematology, 204, no. 2, pp. 566-570. Open access 1
2022	Bennett, MK, Li, M, Tea, MN, Pitman, MR, Toubia, J, Wang, PP, Anderson, D, Creek, DJ, Orlowski, RZ, Gliddon, BL, Powell, JA, Wallington-Beddoe, CT & Pitson, SM 2022, 'Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition', Neoplasia, vol. 24, no. 1, pp. 1-11. Open access 14 13 3
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 25 21 71
2021	Duszyc, K, Gomez, GA, Lagendijk, AK, Yau, MK, Nanavati, BN, Gliddon, BL, Hall, TE, Verma, S, Hogan, BM, Pitson, SM, Fairlie, DP, Parton, RG & Yap, AS 2021, 'Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion', Current Biology, vol. 31, no. 6, pp. 1326-1336. 37 34 7
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 19 18 5
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. Open access 29 27
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 27 24 8
2016	Clarke, JN, Davies, LK, Calvert, JK, Gliddon, BL, Al, SWH, Aloia, AL, Helbig, KJ, Beard, MR, Pitson, SM & Carr, JM 2016, 'Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses', Journal of General Virology, vol. 97, no. 1, pp. 95-109. Open access 17 15
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 50 47
2015	Parham, KA, Zebol, JR, Tooley, KL, Sun, WY, Moldenhauer, LM, Cockshell, MP, Gliddon, BL, Moretti, PA, Tigyi, G, Pitson, SM & Bonder, CS 2015, 'Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis', The FASEB Journal, vol. 29, no. 9, pp. 3638-3653. Open access 76 73 1
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 62 59
2014	Pham, D, Powell, J, Gliddon, B, Moretti, P, Tsykin, A, Van Der Hoek, M, Kenyon, R, Goodall, G & Pitson, S 2014, 'Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1', Oncogene, vol. 33, no. 48, pp. 5559-5568. Open access 25 24
2013	Nguyen, N, Kozer-Gorevich, N, Gliddon, BL, Smolka, AJ, Clayton, AH, Gleeson, PA & van Driel, IR 2013, 'Independent trafficking of the KCNQ1 K+ channel and H+ -K+ -ATPase in gastric parietal cells from mice', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 304, no. 2, pp. 157-166. Open access 14 12
2011	Gunn, PA, Gliddon, BL, Londrigan, SL, Lew, AM, van Driel, IR & Gleeson, PA 2011, 'The Golgi apparatus in the endomembrane-rich gastric parietal cells exist as functional stable mini-stacks dispersed throughout the cytoplasm', Biology of the Cell, vol. 103, no. 12, pp. 559-572. Open access 14 14
2011	Pitman, MR, Barr, RK, Gliddon, BL, Magarey, AM, Moretti, PA & Pitson, SM 2011, 'A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1', The International Journal of Biochemistry and Cell Biology, vol. 43, no. 3, pp. 342-347. 22 18
2008	Van Driel, I, Gunn, P, Gliddon, BL, Nguyen, N & Gleeson, P 2008, 'Isolation, culture and adenoviral transduction of parietal cells from mouse gastric mucosa', Biomedical Materials, vol. 3, no. 3, pp. 1-9. 12 8

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Combinatics	JAPAN
Flinders University	AUSTRALIA
Medical University of South Carolina	UNITED STATES
Monash University	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
SA Pathology	AUSTRALIA
Swinburne University of Technology	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Tennessee	UNITED STATES
University of Texas	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

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Dr Briony Gliddon

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

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