Associate Professor Cameron Bracken

Enterprise Fellow Centre for Cancer Biology

City West Campus (HB9-31)
tel +61 8 830 27828

email Cameron.Bracken@unisa.edu.au

Research Degree Supervisor

About me

I head the Gene Regulatory Networks Laboratory at the Centre for Cancer biology, an alliance between the University of South Australia and SA Pathology. My laboratory focuses on the role of non-coding RNAs (RNAs that do not instruct protein production) as regulators of the gene expression networks that drive and control cancer progression. This includes microRNAs, which act as genetic “off-switches” of protein-coding genes, and long non-coding RNAs which utilize a range of mechanisms to both positively and negatively regulate gene expression. Our research looks at how and why specific genes are selected for regulation, how these regulated genes interact to control biological processes such as cancer, and explores the potential... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Orcid
Scopus

Research

Research focus

Biological Sciences
Medical and Health Sciences
Biochemistry and Cell Biology
Information and Computing Sciences
Genetics

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Bracken, CP, Goodall, GJ & Gregory, PA 2024, 'RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer', Seminars in Cancer Biology, vol. 102-103, pp. 4-16. Open access 2 2
2024	Neumann, DP, Phillips, CA, Lumb, R, Palethorpe, HM, Ramani, Y, Hollier, BG, Selth, LA, Bracken, CP, Goodall, GJ & Gregory, PA 2024, 'Quaking isoforms cooperate to promote the mesenchymal phenotype', Molecular Biology of the Cell, vol. 35, no. 2, pp. 1-17. Open access 1
2024	Neumann, DP, Pillman, KA, Dredge, BK, Bert, AG, Phillips, CA, Lumb, R, Ramani, Y, Bracken, CP, Hollier, BG, Selth, LA, Beilharz, TH, Goodall, GJ & Gregory, PA 2024, 'The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking', RNA Biology, vol. 21, no. 1, article no. 100928, pp. 1-11. Open access 2 2 1
2023	Bracken, CP 2023, ''Crowd-control' by RNA: a pervasive theme in biology', Rna-A Publication of the Rna Society, vol. 29, no. 6, pp. 885-888. Open access 2 1 7
2023	Orang, A, Dredge, BK, Liu, CY, Bracken, JM, Chen, CH, Sourdin, L, Whitfield, HJ, Lumb, R, Boyle, ST, Davis, MJ, Samuel, MS, Gregory, PA, Khew-Goodall, Y, Goodall, GJ, Pillman, KA & Bracken, CP 2023, 'Basonuclin-2 regulates extracellular matrix production and degradation', Life Science Alliance, vol. 6, no. 10, article no. e202301984. Open access 2
2023	Sapkota, S, Pillman, KA, Dredge, BK, Liu, D, Bracken, JM, Kachooei, SA, Chereda, B, Gregory, PA, Bracken, CP & Goodall, GJ 2023, 'On the rules of engagement for microRNAs targeting protein coding regions', Nucleic Acids Research, vol. 51, no. 18, pp. 9938-9951. Open access 4 4 4
2022	Bracken, CP & Goodall, GJ 2022, 'The many regulators of epithelial−mesenchymal transition', Nature Reviews Molecular Cell Biology, vol. 23 no. 2, pp. 89-90. 41 39 10
2022	Migault, M, Sapkota, S & Bracken, CP 2022, 'Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators?', Cellular and Molecular Life Sciences, vol. 79, no. 3, article no. 182. Open access 24 25 1
2021	Pham, VV, Liu, L, Bracken, CP, Nguyen, T, Goodall, GJ, Li, J & Le, TD 2021, 'pDriver: a novel method for unravelling personalized coding and miRNA cancer drivers', Bioinformatics, vol. 37, no. 9, pp. 3285-3292. Open access 11 11 2
2021	Pham, VVH, Liu, L, Bracken, C, Goodall, G, Li, J & Le, TD 2021, 'Computational methods for cancer driver discovery: a survey', Theranostics, vol. 11, no. 11, pp. 5553-5568. Open access 17 15 1
2021	Prompsy, PB, Toubia, J, Gearing, LJ, Knight, RL, Forster, SC, Bracken, CP & Gantier, MP 2021, 'Making use of transcription factor enrichment to identify functional microRNA-regulons', Computational and Structural Biotechnology Journal, vol. 19, pp. 4896-4903. Open access 3 3 2
2021	Wajahat, M, Bracken, CP & Orang, A 2021, 'Emerging functions for snornas and snorna‐derived fragments', International Journal of Molecular Sciences, vol. 22, no. 19, pp. 1-19. Open access 71 67 2
2020	Pham, VV, Liu, L, Bracken, CP, Goodall, GJ, Li, J & Le, TD 2020, 'DriverGroup: a novel method for identifying driver gene groups', Bioinformatics, vol. 36, no. S2, pp. i583-i591. Open access 6 7 1
2020	Saunders, K, Bert, AG, Dredge, BK, Toubia, J, Gregory, PA, Pillman, KA, Goodall, GJ & Bracken, CP 2020, 'Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing', Scientific Reports, vol. 10, no. 1, pp. 1-9. Open access 9 9 9
2019	Pham, VV, Liu, L, Bracken, CP, Goodall, GJ, Long, Q, Li, J & Le, TD 2019, 'CBNA: A control theory based method for identifying coding and non-coding cancer drivers', PLoS Computational Biology, vol. 15, no. 12, article no. e1007538, pp. 1-12. Open access 23 22 5
2019	Pillman, KA, Goodall, GJ, Bracken, CP & Gantier, MP 2019, 'miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR', Rna-A Publication of the Rna Society, vol. 25, no. 2, pp. 232-238. Open access 14 14 1
2019	Pillman, KA, Scheer, KG, Hackett-Jones, E, Saunders, K, Bert, AG, Toubia, J, Whitfield, HJ, Sapkota, S, Sourdin, L, Pham, H, Le, TD, Cursons, J, Davis, MJ, Gregory, PA, Goodall, GJ & Bracken, CP 2019, 'Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA)', Nucleic Acids Research, vol. 47, no. 16, pp. 8606-8619. Open access 6 5 5
2018	Cursons, J, Pillman, KA, Scheer, KG, Gregory, PA, Foroutan, M, Hediyeh-Zadeh, S, Toubia, J, Crampin, EJ, Goodall, GJ, Bracken, CP & Davis, MJ 2018, 'Combinatorial targeting by microRNAs co-ordinates post-transcriptional control of EMT', Cell Systems, vol. 7, no. 1, pp. 77-91. Open access 72 67 28
2018	Narayan, N, Bracken, CP & Ekert, PG 2018, 'MicroRNA-155 expression and function in AML: an evolving paradigm', Experimental Hematology, vol. 62, pp. 1 - 6. Open access 23 21 3
2018	Nejad, C, Pillman, KA, Siddle, KJ, Pépin, G, Anko, ML, McCoy, CE, Beilharz, TH, Quintana-Murci, L, Goodall, GJ, Bracken, CP & Gantier, MP 2018, 'miR-222 isoforms are differentially regulated by type-I interferon', Rna-A Publication of the Rna Society, vol. 24, no. 3, pp. 332-341. Open access 28 26 2
2018	Pillman, KA, Phillips, CA, Roslan, S, Toubia, J, Dredge, BK, Bert, AG, Lumb, R, Neumann, DP, Li, X, Conn, SJ, Liu, D, Bracken, CP, Lawrence, DM, Schreiber, AW, Khew-Goodall, Y, Goodall, GJ & Gregory, PA and 4 other authors 2018, 'miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking', The EMBO Journal, vol. 37, no. 13, article no. e99016, pp. 1-20. Open access 82 82 15
2017	Siira, SJ, Shearwood, A-MJ, Bracken, CP, Rackham, O & Filipovska, A 2017, 'Defects in RNA metabolism in mitochondrial disease', The International Journal of Biochemistry and Cell Biology, vol. 85, pp. 106-113. Open access 5 5
2017	Yu, F, Pillman, KA, Neilsen, CT, Toubia, J, Lawrence, DM, Tsykin, A, Gantier, MP, Callen, DF, Goodall, GJ & Bracken, CP 2017, 'Naturally existing isoforms of miR-222 have distinct functions', Nucleic Acids Research, vol. 45, no. 19, pp. 1137-11385. Open access 58 55 7
2016	Bracken, CP, Scott, HS & Goodall, GJ 2016, 'A network-biology perspective of microRNA function and dysfunction in cancer', Nature Reviews Genetics, vol. 17, pp. 719-732. Open access 570 548 33
2015	Bracken, CP, Khew-Goodall, Y & Goodall, GJ 2015, 'Network-based approaches to understand the roles of miR-200 and other microRNAs in cancer', Cancer Research, vol. 75, no. 13, pp. 2594-2599. Open access 50 50 1
2015	Cursons, J, Leuchowius, K-J, Waltham, M, Tomaskovic-Crook, E, Foroutan, M, Bracken, CP, Redfern, A, Crampin, EJ, Street, I, Davis, MJ & Thompson, EW 2015, 'Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines', Cell Communication and Signaling, vol. 13, article no. 26, pp. 1-21. Open access 43 42 1
2015	Thomson, DW, Pillman, KA, Anderson, ML, Lawrence, DM, Toubia, J, Goodall, G & Bracken, C 2015, 'Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin', Nucleic Acids Research, vol. 43, no. 1, pp. 470-481. Open access 33 30 2
2015	Yu, F, Bracken, CP, Pillman, KA, Lawrence, DM, Goodall, GJ, Callen, DF & Neilsen, PM 2015, 'p53 represses the oncogenic Sno-MiR-28 derived from a SnoRNA', PLoS One, vol. 10, no. 6, article no. e0129190, pp. 1-20. Open access 58 54 5
2014	Bracken, CP, Li, X, Wright, JA, Lawrence, DM, Pillman, KA, Salmanidis, M, Anderson, MA, Dredge, BK, Gregory, PA, Tsykin, A, Neilsen, C, Thomson, DW, Bert, AG, Leerberg, JM, Yap, AS, Jensen, KB, Khew-Goodall, Y & Goodall, GJ 2014, 'Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion', The EMBO Journal, vol. 33, no. 18, pp. 2040-2056. Open access 121 119 13
2014	Li, X, Roslan, S, Johnstone, CN, Wright, J, Bracken, C, Anderson, M, Bert, A, Selth, LA, Anderson, R, Goodall, G, Gregory, PA & Khew-Goodall, Y 2014, 'MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways', Oncogene, vol. 33, no. 31, pp. 4077-4088. 106 99
2014	Salmanidis, M, Pillman, K, Goodall, G & Bracken, C 2014, 'Direct transcriptional regulation by nuclear microRNAs', The International Journal of Biochemistry and Cell Biology, vol. 54, pp. 304-311. 43 59
2013	Neilsen, P, Noll, J, Mattiske, S, Bracken, C, Gregory, PA, Schulz, R, Lim, S, Kumar, R, Suetani, R, Goodall, G & Callen, D 2013, 'Mutant p53 drives invasion in breast tumors through up-regulation of miR-155', Oncogene, vol. 32, no. 24, pp. 2992-3000. Open access 146 135
2013	Thomson, DW, Bracken, CP, Szubert, JM & Goodall, GJ 2013, 'On measuring miRNAs after transient transfection of mimics or antisense inhibitors', PLoS One, vol. 8, no. 1, pp. 1-7. Open access 103 101
2012	Neilsen, CT, Goodall, GJ & Bracken, CP 2012, 'IsomiRs - the overlooked repertoire in the dynamic microRNAome', Trends in Genetics, vol. 28, no. 11, pp. 544-549. 378 356
2011	Bracken, CP, Szubert, JM, Mercer, TR, Dinger, ME, Thomson, DW, Mattick, JS, Michael, MZ & Goodall, GJ 2011, 'Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage', Nucleic Acids Research, vol. 39, no. 13, pp. 5658-5668. Open access 68 65
2011	Gregory, PA, Bracken, CP, Smith, E, Bert, AG, Wright, JA, Roslan, S, Morris, M, Wyatt, L, Farshid, G, Lim, Y-Y, Lindeman, GJ, Shannon, MF, Drew, PA, Khew-Goodall, Y & Goodall, GJ 2011, 'An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition', Molecular Biology of the Cell, vol. 22, no. 10, pp. 1686-1698. Open access 489 460
2011	Mercer, TR, Neph, S, Dinger, ME, Crawford, J, Smith, MA, Shearwood, A-MJ, Haugen, E, Bracken, CP, Rackham, O, Stamatoyannopoulos, JA, Filipovska, A & Mattick, JS 2011, 'The human mitochondrial transcriptome', Cell, vol. 146, no. 4, pp. 645-658. Open access 664 623
2011	Thomson, DW, Bracken, CP & Goodall, GJ 2011, 'Experimental strategies for microRNA target identification', Nucleic Acids Research, vol. 39, no. 16, pp. 6845-6853. Open access 469 439
2010	Mercer, TR, Dinger, ME, Bracken, CP, Kolle, G, Szubert, JM, Korbie, DJ, Askarian-Amiri, ME, Gardiner, BB, Goodall, GJ, Grimmond, SM & Mattick, JS 2010, 'Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome', Genome Research, vol. 20, no. 12, pp. 1639-1650. Open access 74 63
2010	Tam, KK, Russell, DL, Peet, DJ, Bracken, CP, Rodgers, RJ, Thompson, JG & Kind, KL 2010, 'Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity', Molecular and Cellular Endocrinology, vol. 327, no. 1-2, pp. 47-55. 43 41
2009	Bracken, C, Gregory, P, Khew-Goodall, Y & Goodall, G 2009, 'The role of microRNAs in metastasis and epithelial-mesenchymal transition', Cellular and Molecular Life Sciences, vol. 66, no. 10, pp. 1682-1699. 107 96
2008	Bracken, CP, Gregory, PA, Kolesnikoff, N, Bert, AG, Wang, J, Shannon, MF & Goodall, GJ 2008, 'A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition', Cancer Research, vol. 68, no. 19, pp. 7846-7854. Open access 929 877
2008	Bracken, CP, Wall, SJ, Barre, B, Panov, K I, Ajuh, PM & Perkins, ND 2008, 'Regulation of cyclin D1 RNA stability by SNIP1', Cancer Research, vol. 68, no. 18, pp. 7621-7628. Open access 82 79
2008	Gregory, PA, Bracken, CP, Bert, AG & Goodall, GJ 2008, 'MicroRNAs as regulators of epithelial-mesenchymal transition', Cell Cycle, vol. 7, no. 20, pp. 3112-3117. Open access 436 404

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Australian National University	AUSTRALIA
Cancer Council of South Australia	AUSTRALIA
Central Queensland University	AUSTRALIA
Children's Cancer Institute Australia	AUSTRALIA
Deakin University	AUSTRALIA
Flinders University	AUSTRALIA
Harry Perkins Institute of Medical Research	AUSTRALIA
Harvard University	UNITED STATES
Hudson Institute of Medical Research	AUSTRALIA
Institute of Medical and Veterinary Science	AUSTRALIA
Monash University	AUSTRALIA
Murdoch Childrens Research Institute	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Perth Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
St Vincent's Hospital	AUSTRALIA
St. Vincent's Institute of Medical Research	AUSTRALIA
The Institut Pasteur	FRANCE
University of Adelaide	AUSTRALIA
University of Dundee	UNITED KINGDOM
University of Malaya	MALAYSIA
University of Melbourne	AUSTRALIA
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Washington	UNITED STATES
University of Western Australia	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Future Fellowship Australian Research Council (ARC)	2019
Grant review panel National Health and Medical Research Council (NHMRC)	2018
Invited Talk ComBio Conference, Adelaide	2018
Grant review panel National Health and Medical Research Council (NHMRC)	2017
Secretary of organizing committee Science Amongst the Vines Conference	2017
Post-doctoral Fellowship Florey Foundation	2016
Special Interest Group organiser South Australian RNA	2016
Post-doctoral Fellowship Florey Foundation	2015
Review Panel Member Women's and Children's Hospital Research Grant	2015
South Australian Representative Australian Epigenetics Alliance	2015
Special Interest Group organiser South Australian RNA	2015
Invited Talk and Session Chair Japanese and Australian Joint RNA conference (JAJRNA), Sydney	2014
Organising committee Japan/Australian RNA network (JAJRNA) Conference, Sydney	2014
Post-doctoral Fellowship Florey Foundation	2014
Review Panel Member Women's and Children's Hospital Research Grant	2014
Session Chair ComBio Conference, Canberra	2014
Special Interest Group organiser South Australian RNA	2014
Invited Talk and Session Chair ComBio Conference, Perth	2013
Review Panel Member Women's and Children's Hospital Research Grant	2013
Special Interest Group organiser South Australian RNA	2013
Local Organising Committee 4th Australasian Epigenetics Conference	2012
Novel Concepts Grant Review Panel Member National Breast Cancer Foundation	2012
Post-doctoral fellowship National Breast Cancer Foundation	2012
Session Chair Australasian Epigenetics Meeting, Adelaide	2012
Special Interest Group organiser South Australian RNA	2012
Post-doctoral fellowship National Breast Cancer Foundation	2011
Special Interest Group organiser South Australian RNA	2011
Post-doctoral fellowship National Breast Cancer Foundation	2010
Special Interest Group organiser South Australian RNA	2010
Post-doctoral fellowship National Breast Cancer Foundation	2009

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
110943 - Re-examining fundamental assumptions about microRNAs	Current
A novel protein ZCCHC24 as a regulator of breast cancer cell plasticity and metastasis	Current
Alternative splicing networks and their impact on the development of aggressive prostate cancer	Current
Lipid nanoparticles for delivery of nucleic acid vaccines	Current
Nuclear functions of microRNAs that control EMT in breast cancer	Current
Targeting oncogenic signalling with custom RNA drugs	Current
Understanding how the epigenetic field effect exerted by cancers upon their microenvironment promotes tumour progression	Current
Understanding how the epigenetic field effect exerted by cancers upon their microenvironment promotes tumour progression	Current
Developing network inference methods for cancer driver discovery	Completed
Elucidating coding region targets of microRNAs	Completed

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Associate Professor Cameron Bracken

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Future Fellowship

Grant review panel

Invited Talk

Grant review panel

Secretary of organizing committee

Post-doctoral Fellowship

Special Interest Group organiser

Post-doctoral Fellowship

Review Panel Member

South Australian Representative

Special Interest Group organiser

Invited Talk and Session Chair

Organising committee

Post-doctoral Fellowship

Review Panel Member

Session Chair

Special Interest Group organiser

Invited Talk and Session Chair

Review Panel Member

Special Interest Group organiser

Local Organising Committee

Novel Concepts Grant Review Panel Member

Post-doctoral fellowship

Session Chair

Special Interest Group organiser

Post-doctoral fellowship

Special Interest Group organiser

Post-doctoral fellowship

Special Interest Group organiser

Post-doctoral fellowship

Teaching & student supervision

Courses and programs

Courses I teach

Research degree supervision

Gallery