Dr Manuela Klingler-Hoffmann is an experienced cell biologist and biochemist with a background in biophysics. After finishing her PhD in 1999 at the German Cancer Research Centre in Heidelberg, Germany, she has been awarded a prestigious DFG (German Research Foundation) fellowship to work at Monash University in Melbourne. After her time at Monash University, she has been working part time in several laboratories around the world and had a number of career interruptions. In 2016 she was the recipient of a Barbara Kidman Fellowship, which aims to enhance and promote the career of female academics. She has co-supervised more than a dozen Honour’s students and PhD students and numerous vacation scholarship students; with multiple... Read more
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Dr Manuela Klingler-Hoffmann is an experienced cell biologist and biochemist with a background in biophysics. After finishing her PhD in 1999 at the German Cancer Research Centre in Heidelberg, Germany, she has been awarded a prestigious DFG (German Research Foundation) fellowship to work at Monash University in Melbourne. After her time at Monash University, she has been working part time in several laboratories around the world and had a number of career interruptions. In 2016 she was the recipient of a Barbara Kidman Fellowship, which aims to enhance and promote the career of female academics. She has co-supervised more than a dozen Honour’s students and PhD students and numerous vacation scholarship students; with multiple winning internal and external awards, such as the University medal for best the PhD thesis in Biological Sciences. In 2018 she joined the Futures Industries Institute, where she leads a small and dedicated team working on translational research projects in gynaecological cancers. Dr Manuela Klingler-Hoffmann has extensive experiences in a wide array of cell biology, proteomics and mass spectrometry techniques as well as in research design and project management. She is passionate about gender equity and was a member of the self-assessment team for SAGE (http://u.unisa.edu.au/about/sage-pilot).
Doctor of Natural Sciences University of Saarland
Bachelor of Science in Biology University of Saarland
Excludes commercial-in-confidence projects.
Open access indicates that an output is open access.
Acland, M, Mittal, P, Lokman, NA, Klingler-Hoffmann, M, Oehler, MK & Hoffmann, P 2018, 'Mass spectrometry analyses of multicellular tumor spheroids', Proteomics - clinical applications, vol. 12, no. 3, article no. 1700124 , pp. 1-13.
Open access 1 1
Briggs, MT, Condina, MR, Klingler-Hoffmann, M, Arentz, G, Everest-Dass, A V, Kaur, G, Oehler, MK, Packer, NH & Hoffmann, P 2018, 'Translating N‐glycan analytical applications into clinical strategies for ovarian cancer', Proteomics: clinical applications, online, pp. 1-15.
Amare, A, Schubert, K, Klingler-Hoffmann, M, Cohen-Woods, S & Baune, B 2017, 'The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies', Translational psychiatry, vol. 7, no. 1, article no. e1007, pp. 1-12.
Open access 35 28 7
Mittal, P, Klingler-Hoffmann, M, Arentz, G, Winderbaum, L, Kaur, G, Anderson, L, Scurry, J, Leung, Y, Stewart, CJ, Carter, J, Hoffmann, P & Oehler, MK 2017, 'Annexin A2 and alpha actinin 4 expression correlates with metastatic potential of primary endometrial cancer', Biochimica et biophysica acta, vol. 1865, no. 7, pp. 846-857.
3 2 1
Barnett, CP, Nataren, NJ, Klingler-Hoffmann, M, Schwarz, Q, Chong, C-E, Lee, YK, Bruno, DL, Lipsett, J, McPhee, AJ, Schreiber, AW, Feng, J, Hahn, CN & Scott, HS 2016, 'Ectrodactyly and lethal pulmonary acinar dysplasia associated with homozygous FGFR2 mutations identified by exome sequencing', Human mutation, vol. 37, no. 9, pp. 955-963.
Open access 7 4 1
Mittal, P, Klingler-Hoffmann, M, Arentz, G, Winderbaum, L, Lokman, NA, Zhang, C, Anderson, L, Scurry, J, Leung, Y, Stewart, CJ, Carter, J, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Lymph node metastasis of primary endometrial cancers: associated proteins revealed by MALDI imaging', Proteomics, vol. 16, no. 11-12, pp. 1793-1801.
7 5 10
Mittal, P, Klingler-Hoffmann, M, Arentz, G, Zhang, C, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Proteomics of endometrial cancer diagnosis, treatment, and prognosis', Proteomics - clinical applications, vol. 10, no. 3, pp. 217-229.
5 3 10
Weiland, F, Arentz, G, Klingler-Hoffmann, M, McCarthy, P, Lokman, N, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Novel IEF peptide fractionation method reveals a detailed profile of N-terminal acetylation in chemotherapy-responsive and -resistant ovarian cancer cells', Journal of proteome research, vol. 15, no. 11, pp. 4073-4081.
Open access 3 3 1
Zhang, C, Arentz, G, Winderbaum, L, Lokman, NA, Klingler-Hoffmann, M, Mittal, P, Carter, C, Oehler, MK & Hoffmann, P 2016, 'MALDI mass spectrometry imaging reveals decreased CK5 levels in vulvar squamous cell carcinomas compared to the precursor lesion differentiated vulvar intraepithelial neoplasia', International Journal of Molecular Sciences, vol. 17, no. 7, article no. 1088, pp. 1-12.
Open access 5 2 7
Hahn, C, Brautigan, P, Chong, C-E, Janssan, A, Venugopal, P, Lee, Y, Tims, A, Horwitz, M, Klingler-Hoffmann, M & Scott, H 2015, 'Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia', Leukemia, vol.29, no.8, pp. 1795-1797.
Turvey, ME, Klingler-Hoffmann, M, Hoffmann, P & McColl, SR 2015, 'p84 forms a negative regulatory complex with p110ɣ to control PI3Kɣ signalling during cell migration', Immunology and cell biology, vol. 93, no. 8, pp. 735-743.
3 3 10
Humphries, JM, Penno, MA, Weiland, F, Klingler-Hoffmann, M, Zuber, A, Boussioutas, A, Ernst, M & Hoffmann, P 2014, 'Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer', Biochimica et biophysica acta-proteins and proteomics, vol. 1844, no. 5, pp. 1051-1058.
28 28 31
Niu, M, Klingler-Hoffmann, M, Brazzatti, JA, Forbes, B, Akekawatchai, C, Hoffmann, P & McColl, SR 2013, 'Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line', Proteome science, vol. 11, no. 4, pp. 1-12.
Open access 7 3
Sciacca, B, Francois, A, Klingler-Hoffmann, M, Brazzatti, J, Penno, M, Hoffmann, P & Monro, TM 2013, 'Radiative-surface plasmon resonance for the detection of apolipoprotein E in medical diagnostics applications', Nanomedicine: nanotechnology, biology and medicine, vol. 9, no. 4, pp. 550-557.
Open access 31 25 1
Brazzatti, J, Klingler-Hoffmann, M, Haylock-Jacobs, S, Harata-Lee, Y, Niu, M, Higgins, M, Kochetkova, M, Hoffmann, P & McColl, S 2012, 'Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis', Oncogene, vol. 31, no. 18, pp. 2350-2361.
30 29 3
Penno, MA, Klingler-Hoffmann, M, Brazzatti, JA, Boussioutas, A, Putoczki, T, Ernst, M & Hoffmann, P 2012, '2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer', Journal of proteomics, vol. 77, pp. 40-58.
22 20 1
Haylock-Jacobs, S, Comerford, I, Bunting, M, Kara, E, Townley, S, Klingler-Hoffmann, M, Vanhaesebroeck, B, Puri, KD & McColl, SR 2011, 'PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation', Journal of autoimmunity, vol. 36, no. 3-4, pp. 278-287.
53 51 6
Condina, MR, Gustafsson, JO, Klingler-Hoffmann, M, Bagley, CJ, McColl, SR & Hoffmann, P 2010, 'EZYprep LC-coupled MALDI-TOF/TOF MS: an improved matrix spray application for phosphopeptide characterisation', Proteomics, vol. 10, no. 13, pp. 2516-2530.
5 5 6
Condina, MR, Klingler-Hoffmann, M & Hoffmann, P 2010, 'Tyrosine phosphorylation enrichment and subsequent analysis by MALDI-TOF/TOF MS/MS and LC-ESI-IT-MS/MS', Current protocols in protein science, vol. 62, article number 13.11, pp. 13.11.1 - 13.11.26.
François, A, Sciacca, B, Klantsataya, E, Zuber, A, Hoffmann, P, Klinger-Hoffmann, M & Monro, T 2015, 'Surface plasmon scattering: An alternative approach for optical fibers biosensors', in B Lee, Y Rao & S Lee (eds), 5th Asia-Pacific Optical Sensors Conference, SPIE - International Society for Optical Engineering, vol. 9655, pp. 1-4.
External engagement & recognition
|Calistoga Pharmaceuticals Inc.||UNITED STATES|
|Chris O'Brien Lifehouse||AUSTRALIA|
|Ludwig Institute for Cancer Research||AUSTRALIA|
|Murdoch Childrens Research Institute||AUSTRALIA|
|Queen Mary University of London||UNITED KINGDOM|
|Royal Adelaide Hospital||AUSTRALIA|
|Royal Prince Alfred Hospital||AUSTRALIA|
|University of Adelaide||AUSTRALIA|
|University of Manchester||UNITED KINGDOM|
|University of Melbourne||AUSTRALIA|
|University of New South Wales||AUSTRALIA|
|University of Science, Malaysia||MALAYSIA|
|University of South Australia||AUSTRALIA|
|University of Washington||UNITED STATES|
|University of Western Australia||AUSTRALIA|
|Walter and Eliza Hall Institute of Medical Research||AUSTRALIA|
|Women's and Children's Hospital||AUSTRALIA|