With standout facilities and strong industry links, the School prepares students for careers in health and medical science.
Doctor of Philosophy Flinders University of SA
Bachelor of Science (Honours) Flinders University of SA
Bachelor of Science Flinders University of SA
Excludes commercial-in-confidence projects.
Open access indicates that an output is open access.
Sharma, S, Martin, S, Sykes, MJ, Dave, A, Hewitt, AW, Burdon, KP, Ronci, M, Voelcker, NH & Craig, JE 2016, 'Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome', Experimental Eye Research, vol. 146, pp. 212-223.
Le, BT, Kumarasiri, M, Adams, J, Yu, M, Milne, RW, Sykes, MJ & Wang, S 2015, 'Targeting Pim kinases for cancer treatment: Opportunities and challenges', Future Medicinal Chemistry, vol. 7, no. 1, pp. 35-53.
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Simpson, BS, Ndi, CP, Sykes, MJ, Claudie, DJ, McKinnon, RA & Semple, SJ 2015, 'Antiproliferative aporphine alkaloids from Litsea glutinosa and ethnopharmacological relevance to Kuuku I'yu traditional medicine', Australian Journal of Chemistry: an international journal for chemical science, vol. 69, pp. 145-151.
Teo, T, Yang, Y, Yu, M, Sunita, K, Gillam, T, Hou, J, Schmid, R, Kumarasiri, M, Diab, S, Albrecht, H, Sykes, M & Wang, S 2015, 'An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis', European Journal of Medicinal Chemistry, vol. 103, pp. 539-550.
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Teo, THS, Lam, FK, Yu, M, YANG, Y, KC Basnet, S, Albrecht, H, Sykes, MJ & Wang, S 2015, 'Pharmacologic inhibition of MNKs in acute myeloid leukemia', Molecular Pharmacology, vol. 88, no. 2, pp. 380-389.
Al Haj Diab, S, Teo, THS, Kumarasiri, M, Li, P, Yu, M, Lam, FK, KC Basnet, S, Sykes, MJ, Albrecht, H, Milne, RW & Wang, S 2014, 'Discovery of 5-( 2-( Phenylamino) pyrimidin-4-yl) thiazol2( 3H)- one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation', ChemMedChem: chemistry enabling drug discovery, vol. 9, no. 5, pp. 962-972.
Open access 17 18 1
Teo, THS, Yu, M, Yang, Y, Gillam, TA, Lam, FK, Sykes, MJ & Wang, S 2014, 'Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells', Cancer Letters, vol. 357, pp. 612-623.
Hou, J, Teo, THS, Sykes, MJ & Wang, S 2013, 'Insights into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase', ACS Medicinal Chemistry Letters, vol. 4, no. 8, pp. 736-741.
Laurie, KJ, Dave, A, Strage, T, Souzeau, E, Chataway, T, Sykes, MJ, Casey, T, Teo, THS, Pater, J, Craig, J, Sharma, S & Burdon, K 2013, 'Identification of a Novel Oligomerization Disrupting Mutation in CRYAA Associated with Congenital Cataract in a South Australian Family', Human Mutation, vol. 34, no. 3, pp. 435-438.
Pehere, A, Pietsch, M, Gutschow, M, Neilsen, P, Pedersen, D, Nguyen, S, Zvarec, O, Sykes, MJ, Callen, D & Abell, A 2013, 'Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors', Chemistry: A European Journal, vol. 19, no. 24, pp. 7975-7981.
Callegari, S, Gregory, PA, Sykes, MJ, Bellon, J, Andrews, S, McKinnon, RA & De Barros Lopes, M 2012, 'Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity', PLoS Genetics, vol. 8, no. 6, pp. 1-12.
Open access 1 1
Nussio, M, Voelcker, N, Miners, J, Lewis, B, Sykes, MJ & Shapter, J 2010, 'AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers', Chemistry and Physics of Lipids, vol. 163, no. 2, pp. 182-189.
Nussio, M, Voelcker, N, Sykes, MJ, McInnes, SJP, Gibson, C, Lowe, RD, Miners, J & Shapter, J 2008, 'Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.', Biointerphases: an open access journal for the biomaterials interface community, vol. 3, no. 4, pp. 96-104.
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Sykes, M, McKinnon, RA & Miners, J 2008, 'Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates', Journal of Medicinal Chemistry, vol. 51, no. 4, pp. 780-791.
|University of South Australia||AUSTRALIA|
|University of Western Australia||AUSTRALIA|
Supervisions from 2010 shown
|Thesis title||Student status|
|Antimicrobial effect of nanoparticles against multidrug resistant bacterial pathogens||Current|
|Discovery of protein kinase inhibitors as potential anti-cancer agents||Current|
|Enriching pharmacoepidemiology with molecular similarity approaches in order to support adverse event detection||Current|
|Evaluation of anticancer activity and cellular effects of some selected small molecules (cdk9 inhibitors) and their combination with selective anticancer drugs against human cancer cell lines||Current|
|Molecular modeling of calpain inhibitors||Current|
|Pharmacological investigation of anti-inflammatory diterpenoid compounds isolated from Dodonaea polyandra||Current|
|Discovery and evaluation of MNK inhibitors as potential anti-cancer agents||Completed|
|Discovery and evaluation of styrylsulfonyl-methylpyridine derivatives as anticancer agents||Completed|