Hello and welcome to the homepage for Associate Professor Maurizio Costabile at the University of South Australia (UniSA). I have been employed at UniSA since 1998. I am a teaching-focussed, Associate professor in the Clinical and Health Sciences Academic Unit. I received my Bachelor of Science degree with First Class Honours in Biochemistry from the Flinders University of South Australia and I completed my PhD in Immunology at the Women's and Children's Hospital through the University of Adelaide. I was the Honours co-ordinator for the Laboratory Medicine Program for over 15 years and I was a higher degree research coordinator between 2016-24. I can be contacted for matters relating to Honours study, as well as postgraduate study... Read more
About me
Hello and welcome to the homepage for Associate Professor Maurizio Costabile at the University of South Australia (UniSA). I have been employed at UniSA since 1998. I am a teaching-focussed, Associate professor in the Clinical and Health Sciences Academic Unit. I received my Bachelor of Science degree with First Class Honours in Biochemistry from the Flinders University of South Australia and I completed my PhD in Immunology at the Women's and Children's Hospital through the University of Adelaide. I was the Honours co-ordinator for the Laboratory Medicine Program for over 15 years and I was a higher degree research coordinator between 2016-24. I can be contacted for matters relating to Honours study, as well as postgraduate study within my academic unit. I am an active teacher, being responsible for Biochemistry (BIOL 2014) in SP2 and Immunology (BIOL 2037) in SP5. I have a strong interest in educational research, with an emphasis on Stroyline and Unity-based interactive simulations, mind mapping and 3D-printed objects as learning aids.
About me
Member of the Australian Society for Biochemistry and Molecular Biology (ASBMB) and member of the Education SIG
Member of the Australian Society for Immunology (ASI) and member of the Education SIG
Member of the American Association for Immunology (AAI) and member of the Education SIG
Past Member of the Australian Society for Medical Research (ASMR)
About me
| Date | Title |
|---|---|
| 04/09/2017 | |
| 11/08/2017 |
STEM Teaching Award Video, https://www.youtube.com/watch?v=1FrRqtt_6so&list=PL_4PIZNEhGER9hICT4EZxJypecdoUWwRI&index=17 |
About me
Doctor of Philosophy The University of Adelaide
Bachelor of Science (Honours) Flinders University
Bachelor of Science (Honours) Flinders University
I have been a staff member at UniSA since 1998.
Cancer Biology
I am a member of the Molecular Signalling laboratory in the Centre for Cancer Biology. The laboratory focusses on the biology of the enzyme, sphingosine kinase, which plays a central role in cancer development.
Tumour evasion
In the past I have examined the control of the enzyme, indoleamine dioxygenase (IDO). IDO is the first enzyme involved in the metabolism of the essential amino acid, tryptophan. Decreased levels of tryptophan lead to cell cycle arrest and inhibition of cellular proliferation.Cancer cells express high levels of IDO, and use this enzyme to suppress the local inflammatory response. As a result, targeted inhibition of this enzyme would be useful in the prevention of tumour evasion.
Research
Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus
Open access indicates that an output is open access.
| Year | Output |
|---|---|
| 2019 |
Open access
11
11
|
| 2017 |
6
4
|
| 2016 |
10
8
|
| 2016 |
Open access
79
80
6
|
| Year | Output |
|---|---|
| 2023 |
|
| 2020 |
|
| Year | Output |
|---|---|
| 2024 |
Open access
|
| 2024 |
Open access
4
5
|
| 2024 |
Open access
|
| 2024 |
Open access
2
2
|
| 2024 |
Open access
|
| 2024 |
Open access
|
| 2024 |
Open access
3
|
| 2024 |
|
| 2024 |
|
| 2023 |
Open access
1
1
1
|
| 2023 |
Open access
14
|
| 2022 |
Open access
6
5
1
|
| 2022 |
Open access
18
14
8
|
| 2022 |
Open access
2
2
2
|
| 2022 |
Open access
25
21
71
|
| 2022 |
Open access
4
4
1
|
| 2022 |
Open access
9
5
9
|
| 2022 |
Open access
4
3
1
|
| 2021 |
Open access
8
7
3
|
| 2021 |
Open access
10
10
|
| 2021 |
Open access
2
|
| 2020 |
Open access
|
| 2020 |
16
17
|
| 2020 |
Open access
|
| 2020 |
Open access
4
4
1
|
| 2020 |
Open access
3
|
| 2020 |
Open access
27
20
3
|
| 2019 |
3
3
1
|
| 2019 |
Open access
19
18
5
|
| 2019 |
Open access
11
11
|
| 2018 |
Open access
5
5
|
| 2017 |
6
4
|
| 2017 |
Open access
|
| 2016 |
10
8
|
| 2016 |
Open access
79
80
6
|
| 2014 |
Open access
21
20
|
| 2012 |
14
14
|
| 2011 |
7
8
|
| 2010 |
Open access
4
|
| 2010 |
Open access
26
|
| 2009 |
Costabile, M 2009, 'Monoclonal antibodies', Australian Pharmacist, vol. 28, no. 5, pp. 410-414.
10
|
| 2009 |
Costabile, M 2009, 'Temozolomide', Australian Pharmacist, vol. 28, no. 8, pp. 671-673. |
| 2008 |
Open access
14
30
|
Research
Cancer Biology
I am a member of the Molecular Signalling laboratory in the Centre for Cancer Biology. The laboratory focusses on the biology of the enzyme, sphingosine kinase, which plays a central role in cancer development.
Tumour evasion
In the past I have examined the control of the enzyme, indoleamine dioxygenase (IDO). IDO is the first enzyme involved in the metabolism of the essential amino acid, tryptophan. Decreased levels of tryptophan lead to cell cycle arrest and inhibition of cellular proliferation.Cancer cells express high levels of IDO, and use this enzyme to suppress the local inflammatory response. As a result, targeted inhibition of this enzyme would be useful in the prevention of tumour evasion.
Teaching Awards
2021: Winner, Cheers-Buchanan Education Award, Australasian Society for Immunology (ASI).
2017: Finalist, STEM Educator of the year. Science Excellence Awards.
2016: Awarded an Online Learning Consortium (OLC) Effective Practice Award for my simulation titled, "Improving Student Learning of Biochemistry Using Simulations".
2015: Awarded a UniSA Digital Learning Citation for Outstanding Contributions to Student Learning "For the creation of innovative, engaging and interactive digital simulations that facilitate student learning".
2014: Awarded an Office of Learning and Teaching Citation for "Outstanding Contribution to Student Learning".
2013: Awarded a UniSA Citation for "Outstanding Contribution to Student Learning".
External engagement & recognition
| Organisation | Country |
|---|---|
| Burnet Institute | AUSTRALIA |
| Chuulangun Aboriginal Corporation | AUSTRALIA |
| Monash University | AUSTRALIA |
| QIMR Berghofer Medical Research Institute | AUSTRALIA |
| Royal Children's Hospital | UNITED KINGDOM |
| University of Adelaide | AUSTRALIA |
| University of South Australia | AUSTRALIA |
| University of Stirling | UNITED KINGDOM |
| University of Sydney | AUSTRALIA |
| Walter and Eliza Hall Institute of Medical Research | AUSTRALIA |
| Women's and Children's Hospital | AUSTRALIA |
External engagement & recognition
| Engagement/recognition | Year |
|---|---|
SDR Scientific Education AwardAustralian Society for Biochemistry and Molecular Biology |
2023 |
Guest Editor of Immunology and Cell Biology Immunology Pedagogy Special Edition (2022 impact factor 4.0)Immunology and Cell Biology Journal |
2022 |
MemberAustralian Society for Biochemistry and Molecular Biology (ASBMB) |
2017 |
MemberAustralian Society for Medical Research (ASMR) |
2017 |
MemberAustralian Society for Immunology (ASI) |
2017 |
Nominee, STEM Educator of the YearSouth Australian Science Excellence Awards |
2017 |
Award for improving student learning of college biochemistry using simulationsOnline Learning Consortium |
2016 |
Citations for Outstanding Contributions to Student LearningOffice for Learning and Teaching, Department of Education and Training, Australian Government |
2014 |
2016-Research Degree Coordinator for Pharmacy and Medical Sciences and now Clinical and Health Sciences.
Immunology
Biochemistry
Molecular Pathogenesis of disease
Primary Immunodeficiency diseases
Teaching & student supervision
Teaching & student supervision
Supervisions from 2010 shown
| Thesis title | Student status |
|---|---|
| Developing cross-disci;inary essential skills using learning analytic methods in students across health disciplines | Current |
| Hand skill training with custom haptics, real-time visual instruction, and immersive technologies | Current |
| Targeting sphingosine kinase 1 to overcome venetoclax resistance in acute myeloid leukemia | Current |
| Methylglyoxal induces chromosomal instability under normal and folic acid deficient conditions | Completed |
| Regulation of indoleamine 2,3-dioxygenase (IDO) by fatty acids and their eicosanoid derivatives in THP-1 cells and human monocytes | Completed |
| The characterisation of a novel haplotype within TNFRSF13B associated with increased risk of development of common variable immunodeficiency | Completed |
| The role of fatty acids on dicarbonyl- induced protein glycation, receptor expression and inflammatory biomarkers | Completed |
