Dr Parvathy Venugopal

Research Fellow Centre for Cancer Biology

email Parvathy.Venugopal@unisa.edu.au

Research Degree Supervisor

About me

Dr. Parvathy Venugopal is a research fellow at the Centre for Cancer Biology in Adelaide, specialising in the genetics of inherited bone marrow failure syndromes and leukemia predisposition. With a strong foundation in regenerative medicine, she brings expertise in stem cell biology and disease modelling. Her work has significantly advanced the understanding of germline and somatic mutations driving inherited hematological disorders. She has been instrumental in the development of in vitro and in vivo models that are advancing knowledge of disease mechanisms in bone marrow failure and hematologic malignancies. Her research is driven by a strong interest in identifying the underlying genetic lesions that cause disease and in understanding... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Clinical Sciences
Medical and Health Sciences
Biochemistry and Cell Biology
Biological Sciences
Cardiovascular Medicine and Haematology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2024	Venugopal, P, Arts, P, Fox, LC, Simons, A, Ross, DM, Frank, MS, Ha, TT, Jackson, MR, Arriola-Martinez, L, Kenyon, R, Brown, AL, Hahn, CN & Scott, HS 2024, 'Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion', Blood Advances, vol. 8, no. 13, pp. 3437-3443. Open access 4 1 10
2023	Kazenwadel, J, Venugopal, P, Oszmiana, A, Toubia, J, Panara, V, Piltz, SG, Brown, C, Ma, W, Schreiber, AW, Koltowska, K, Taoudi, S, Thomas, PQ, Scott, HS & Harvey, NL 2023, 'A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature', Nature, vol. 614, no. 7947, pp 343-348. 29 29 162
2021	Homan, CC, Venugopal, P, Arts, P, Shahrin, NH, Feurstein, S, Rawlings, L, Lawrence, DM, Andrews, J, King-Smith, SL, Harvey, NL, Brown, AL, Scott, HS & Hahn, CN 2021, 'GATA2 deficiency syndrome: a decade of discovery', Human Mutation, vol. 42, no. 11, pp. 1399-1421. Open access 51 43 15
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 56 54 3
2011	Venugopal, P, Balasubramanian, S, Majumdar, AS & Ta, M 2011, 'Isolation, characterization, and gene expression analysis of Wharton's jelly-derived mesenchymal stem cells under xeno-free culture conditions', Stem Cells and Cloning: Advances and Applications, vol. 2011, no. 4, pp. 39-50. Open access 45 34

Journal Articles

Year	Output
2025	Homan, CC, Scott, HS & Venugopal, P 2025, 'Another Fanconi anemia gene joins the club', Journal of Clinical Investigation, vol. 135, no. 11, article no. e192382, pp. 1-5. Open access
2024	Venugopal, P, Arts, P, Fox, LC, Simons, A, Ross, DM, Frank, MS, Ha, TT, Jackson, MR, Arriola-Martinez, L, Kenyon, R, Brown, AL, Hahn, CN & Scott, HS 2024, 'Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion', Blood Advances, vol. 8, no. 13, pp. 3437-3443. Open access 4 1 10
2024	Zerella, JR, Homan, CC, Arts, P, Lin, X, Spinelli, SJ, Venugopal, P, Babic, M, Brautigan, PJ, Arriola-Martinez, L, Parker, WT, Branford, S, Ross, DM, Brown, AL, Scott, HS & Hahn, CN 37 other authors and 1 consortium 2024, 'Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition', Blood, vol. 144, no. 17, pp. 1765-1780. Open access 8 7 23
2023	Homan, CC, Drazer, MW, Yu, K, Lawrence, DM, Feng, J, Arriola-Martinez, LA, Ha, TT, Venugopal, P, Arts, P, King-Smith, S, Cheah, JJC, Armstrong, M, Wang, P, Babic, M, Scott, HS & Brown, AL and 49 other authors 2023, 'Somatic mutational landscape of hereditary hematopoietic malignancies caused by germ line RUNX1, GATA2, and DDX41 variants', Blood Advances, vol. 7, no. 20, pp. 6092-6107. Open access 29 25 3
2023	Kazenwadel, J, Venugopal, P, Oszmiana, A, Toubia, J, Panara, V, Piltz, SG, Brown, C, Ma, W, Schreiber, AW, Koltowska, K, Taoudi, S, Thomas, PQ, Scott, HS & Harvey, NL 2023, 'A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature', Nature, vol. 614, no. 7947, pp 343-348. 29 29 162
2021	Homan, CC, Venugopal, P, Arts, P, Shahrin, NH, Feurstein, S, Rawlings, L, Lawrence, DM, Andrews, J, King-Smith, SL, Harvey, NL, Brown, AL, Scott, HS & Hahn, CN 2021, 'GATA2 deficiency syndrome: a decade of discovery', Human Mutation, vol. 42, no. 11, pp. 1399-1421. Open access 51 43 15
2020	Venugopal, P, Gagliardi, L, Forsyth, C, Feng, J, Phillips, K, Babic, M, Poplawski, NK, Rienhoff, HY, Schreiber, AW, Hahn, CN, Brown, AL & Scott, HS 2020, 'Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss', BMC Medical Genetics, vol. 21, no. 1, article no. 35, pp. 1-5. Open access 3 3 1
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 56 54 3
2015	Hahn, C, Brautigan, P, Chong, C-E, Janssan, A, Venugopal, P, Lee, Y, Tims, A, Horwitz, M, Klingler-Hoffmann, M & Scott, H 2015, 'Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia', Leukemia, vol.29, no.8, pp. 1795-1797. 9 10
2015	Hahn, CN, Venugopal, P, Scott, HS & Hiwase, DK 2015, 'Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy', Immunological Reviews, vol. 263, no. 1, pp. 257-278. 42 38 1
2015	Hu, Z, Scott, HS, Qin, G, Zheng, G, Chu, X, Xie, L, Adelson, DL, Oftedal, BE, Venugopal, P, Babic, M, Hahn, CN, Zhang, B, Wang, X, Li, N & Wei, C 2015, 'Revealing missing human protein isoforms based on Ab Initio Prediction, RNA-seq and proteomics', Scientific Reports, vol. 5, article no. 10940, pp. 1-15. Open access 32 26 10
2014	Swamynathan, P, Venugopal, P, Kannan, S, Thej, C, Kolkundar, U, Bhagwat, S, Ta, M, Majumdar, AS & Balasubramanian, S 2014, 'Are serum-free and xeno-free culture conditions ideal for large scale clinical grade expansion of Wharton's jelly derived mesenchymal stem cells?: a comparative study', Stem Cell Research and Therapy, vol. 5, article no. 88, pp. 1-17. Open access 96 90
2013	Balasubramanian, S, Thej, C, Venugopal, P, Priya, N, Zakaria, Z, SundarRaj, S & Majumdar, AS 2013, 'Higher propensity of Wharton's jelly derived mesenchymal stromal cells towards neuronal lineage in comparison to those derived from adipose and bone marrow', Cell Biology International, vol. 37, no. 5, pp. 507-515. 58 48
2012	Balasubramanian, S, Venugopal, P, SundarRaj, S, Zakaria, Z, Majumdar, AS & Ta, M 2012, 'Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells', Cytotherapy, vol. 14, no. 1, pp. 26-33. 48 44
2011	Venugopal, P, Balasubramanian, S, Majumdar, AS & Ta, M 2011, 'Isolation, characterization, and gene expression analysis of Wharton's jelly-derived mesenchymal stem cells under xeno-free culture conditions', Stem Cells and Cloning: Advances and Applications, vol. 2011, no. 4, pp. 39-50. Open access 45 34
2010	Nekanti, U, Dastidar, S, Venugopal, P, Totey, S & Ta, M 2010, 'Increased proliferation and analysis of differential gene expression in human Wharton's jelly-derived mesenchymal stromal cells under hypoxia', International Journal of Biological Sciences, vol. 6, no. 5, pp. 499-512. Open access 151 132
2010	Nekanti, U, Mohanty, L, Venugopal, P, Balasubramanian, S, Totey, S & Ta, M 2010, 'Optimization and scale-up of Wharton's jelly-derived mesenchymal stem cells for clinical applications', Stem Cell Research, vol. 5, no. 3, pp. 244-254. Open access 117 95

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Chinese Academy of Sciences	CHINA
Hudson Institute of Medical Research	AUSTRALIA
Imago Biosciences	UNITED STATES
Institute for Medical Research, Malaysia	MALAYSIA
Institute of Medical Research, Malaysia	MALAYSIA
Jarrett St Specialist Centre	AUSTRALIA
Manipal University	INDIA
National Human Genome Research Institute	UNITED STATES
Northwestern University Feinberg School of Medicine	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
Radboud Institute for Molecular Life Sciences	NETHERLANDS
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Second Military Medical University	CHINA
Shanghai Center for Bioinformation Technology	CHINA
Shanghai Jiao Tong University	CHINA
Stempeutics Research	MALAYSIA
The Indian Institutes of Science Education and Research	INDIA
University of Adelaide	AUSTRALIA
University of Chicago	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Washington	UNITED STATES
Uppsala University	SWEDEN
Vanderbilt University Medical Centre	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
ASMR Early Career Researcher Poster Presentation Award Australian Society for Medical Research	2017
Invited Speaker, 16th One-Day symposium Human Genetics Society of Australasia - SA Branch	2017
Invited Presentation 19th Annual Scientific Weekend Meeting, Adelaide Blood Club	2016

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
109455 - Examining the impact of environmental stressors and mutant microenvironment on disease development in models of inherited predisposition to haematological malignancies	Current

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Dr Parvathy Venugopal

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

ASMR Early Career Researcher Poster Presentation Award

Invited Speaker, 16th One-Day symposium

Invited Presentation

Teaching & student supervision

Courses and programs

Research degree supervision

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