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Professor Stuart Pitson

  • Research Professor Centre for Cancer Biology
  • City West Campus (HB10-11)
  • tel +61 8 830 27832
  • email Stuart.Pitson@unisa.edu.au
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About me

About me

Professor Stuart Pitson

Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

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About me

Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including the cloning of the first human sphingosine kinase, and identification of key phosphorylations and protein interactions relating to the sphingosine kinases that have (patho)physiological significance, as well as the development of novel inhibitors with potential clinical application.

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Professional Associations

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Experience

Qualifications

  • PhD in Biochemistry/Biotechnology La Trobe University

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Research

Research themes

  • Cancer

Research focus

  • Biochemistry and Cell Biology
  • Clinical Sciences
  • Biological Sciences
  • Medical and Health Sciences
  • Oncology and Carcinogenesis
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Research

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Projects

Excludes commercial-in-confidence projects.

  • Targeting sphingolipid metabolism in disease, NHMRC - Senior Principal Research Fellowship, 01/01/2019 - 31/12/2023

  • Targeting sphingosine kinase 1 to sensitise acute myeloid leukaemia to BH3 mimetic therapy, NHMRC - Project Grant, 01/01/2018 - 31/12/2020

  • Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019

  • Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/05/2019

  • Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018

  • Sphingosine kinase as a target for anti-cancer therapy, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2018

  • Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018

  • Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/03/2018

  • Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer, NHMRC - Project Grant, 01/01/2015 - 31/12/2017

  • Targeting sphingosine kinases to improve glioblastoma therapy, Neurosurgical Research Foundation, 21/06/2016 - 30/09/2017

  • Targeting Sphingosine Kinase 1C Degradation to Enhance Chemosensitivity', Central Adelaide Local Health Network Incorporated, 01/01/2016 - 30/06/2017

  • Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017

  • Liquid handling robot and cell analysis systems, Neurosurgical Research Foundation, 17/10/2016 - 30/05/2017

  • Enhancing wound healing via modulation of the sphingosine kinase/ sphingosine 1-phosphate pathway, Royal Adelaide Hospital, 12/02/2015 - 28/02/2016

  • Targeting sphingosine kinase 1c degradation to enhance cancer chemotherapeutic sensitivity, Cancer Council SA - Beat Cancer, 01/01/2015 - 31/12/2015

  • Roles and regulations of sphingosine kinase 1 during dengue virus infection, NHMRC - Project Grant, 01/01/2014 - 31/12/2015

  • A new target for allergic inflammation: the sphingolipid pathway, NHMRC - Project Grant, 01/01/2014 - 31/12/2015

  • Targetting the CIB1-sphingosine kinase interaction in oncogenesis, NHMRC - Project Grant, 01/01/2014 - 30/04/2015

  • Characterising a highly oncogenic variant of sphingosine kinase 1, Cancer Council SA - Beat Cancer, 01/01/2014 - 31/12/2014

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Outputs

Research since 2008 is shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year Output
2018

Pitman, MR, Davies, LT & Pitson, SM 2018, 'An improved isoform-selective assay for sphingosine kinase 1 activity', in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate, Humana Press, Inc., US, ch. 2, pp. 9-20.

1
2013

Pitman, MR, Jarman, K, Leclercq, T, Pham, D & Pitson, SM 2013, 'Sphingosine kinases: biochemistry, regulation, and roles', in J Chun et al. (eds), Lysophospholipid Receptors: Signaling and Biochemistry, Wiley-Blackwell, US, ch. 9, pp. 153-183.

1 2

Journal Articles

Year Output
2018

Lidgerwood, GE, Pitson, SM, Bonder, C & Pébay, A 2018, 'Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology', Progress in lipid research, vol. 72, pp. 42-54.

2018

Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2018, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, online, pp. 1-15.

Open access
2018

Poltavets, V, Kochetkova, M, Pitson, SM & Samuel, MS 2018, 'The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity', Frontiers in oncology, vol. 8, article no. 431, pp. 1-19.

Open access 1
2018

Wallington-Beddoe, CT, Sobieraj-Teague, M, Kuss, BJ & Pitson, SM 2018, 'Resistance to proteasome inhibitors and other targeted therapies in myeloma', British journal of haematology, vol. 182, pp. 11-28.

4 4 5
2018

Wallington-Beddoe, CT, Xie, V, Tong, D, Powell, JA, Lewis, AC, Davies, L, Pitson, SM, Bradstock, KF & Bendall, LJ 2018, 'Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia', British journal of haematology, online, pp. 1-4.

1
2018

Woodcock, JM, Goodwin, KL, Sandow, JJ, Coolen, C, Perugini, MA, Webb, A I, Pitson, SM, Lopez, AF & Carver, JA 2018, 'Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity', Journal of biological chemistry, vol. 293, no. 1, pp. 89-99.

Open access 1 1 3
2017

Al-Shujairi, WH, Clarke, JN, Davies, LT, Alsharifi, M, Pitson, SM & Carr, JM 2017, 'Intracranial injection of dengue virus induces interferon stimulated genes and CD8+ T cell infiltration by sphingosine kinase 1 independent pathways', PLoS one, vol. 12, article no. e0169814, pp. 1-21.

Open access 1 1 1
2017

Aloia, AL, Calvert, JK, Clarke, JN, Davies, LT, Helbig, KJ, Pitson, SM & Carr, JM 2017, 'Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection', Clinical & translational immunology, vol. 6, no. 7, article no. e151, pp. 1-9.

Open access 2 1
2017

Hein, N, Cameron, DP, Hannan, KM, Nguyen, N-Y, Powell, JA, Pitson, SM & Hannan, RD and 23 other authors 2017, 'Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population', Blood, vol. 129, pp. 2882-2895.

7 6 62
2017

Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782.

13 12 85
2017

Rojas-Canales, D, Penko, D, Myo Min, KK, Parham, KA, Peiris, H, Haberberger, R V, Pitson, SM, Drogemuller, C, Keating, DJ, Grey, ST, Coates, PT, Bonder, CS & Jessup, CF 2017, 'Local sphingosine kinase 1 activity improves islet transplantation', Diabetes, vol. 66, no. 5, pp. 1301-1311.

Open access 1 2 6
2017

Tran, HB, Jersmann, H, Truong, TT, Hamon, R, Roscioli, E, Ween, M, Pitman, MR, Pitson, SM, Hodge, G, Reynolds, PN & Hodge, S 2017, 'Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD', PLoS one, vol.12, no. 11, pp. 1-14.

Open access 4 3 1
2017

Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616.

Open access 7 8 8
2017

Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627.

9 7
2017

Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834.

Open access 8 6 2
2016

Aurelio, L, Scullino, C V, Pitman, MR, Sexton, A, Oliver, V, Davies, L, Rebello, RJ, Furic, L, Creek, DJ, Pitson, SM & Flynn, BL 2016, 'From sphingosine kinase to dihydroceramide desaturase: A structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)', Journal of Medicinal Chemistry, vol. 59, pp. 965-984.

11 12
2016

Clarke, JN, Davies, LK, Calvert, JK, Gliddon, BL, Al, SWH, Aloia, AL, Helbig, KJ, Beard, MR, Pitson, SM & Carr, JM 2016, 'Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses', Journal of General Virology, vol. 97, no. 1, pp. 95-109.

Open access 11 11 1
2016

Dimasi, DP, Pitson, SM & Bonder, CS 2016, 'Examining the role of sphingosine kinase-2 in the regulation of endothelial cell barrier integrity', Microcirculation, vol. 23, no. 3, pp. 248-265.

Open access 4 4
2016

McNaughton, M, Pitman, M, Pitson, SM, Pyne, NJ & Pyne, S 2016, 'Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells', Oncotarget, vol. 7, no. 13, pp. 16663-16675.

Open access 31 26
2016

Neubauer, HA & Pitson, SM 2016, 'Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence', F1000Research, vol. 5, article no. 2825 , pp. 1-12.

Open access 2
2016

Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899.

Open access 12 9
2016

Pitman, MR, Costabile, M & Pitson, SM 2016, 'Recent advances in the development of sphingosine kinase inhibitors', Cellular signalling, vol. 28, no. 9, pp. 1349-1363.

Open access 24 25
2016

Schoenwaelder, SM, Darbousset, R, Cranmer, SL, Ramshaw, HS, Woodcock, J, Pitson, S, Lopez, AF & Jackson, SP and 13 other authors 2016, '14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function', Nature communications, vol. 7, article no. 12862, pp. 1-15.

Open access 16 14 1
2016

Sun, WY, Dimasi, DP, Pitman, MR, Zhuang, Y, Heddle, R, Pitson, SM, Grimbaldeston, MA & Bonder, CS 2016, 'Topical application of fingolimod perturbs cutaneous inflammation', Journal of immunology, vol. 196, no. 9, pp. 3854-3864.

9 7 1
2016

Tran, HB, Barnawi, J, Ween, M, Hamon, R, Roscioli, E, Hodge, G, Reynolds, PN, Pitson, SM, Davies, LT, Haberberger, R & Hodge, S 2016, 'Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720', Journal of leukocyte biology, vol. 100, no.1, pp. 195-202.

10 7 1
2015

Aloia, AL, Abraham, AM, Bonder, CS, Pitson, SM & Carr, JM 2015, 'Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs', Mediators of Inflammation, vol. 2015, article no. 509306, pp. 1-13.

Open access 7 4 2
2015

Barnawi, J, Tran, H, Jersmann, H, Pitson, SM, Roscioli, E, Hodge, G, Meech, R, Haberberger, R & Hodge, S 2015, 'Potential link between the sphingosine-1-phosphate (S1P) system and defective alveolar macrophage phagocytic function in chronic obstructive pulmonary disease (COPD)', PLoS one, vol. 10, no. 10, article no. e0122771.

Open access 16 14
2015

Beroukas, D, Selhorst, M, Pitson, SM, Matusica, D, Gibbins, IL, Kress, M & Haberberger, R V 2015, 'Sphingosine kinase 1 in murine dorsal root ganglia', AIMS Molecular Science, vol. 2, no. 1, pp. 22-33.

Open access 1
2015

Calvert, JK, Helbig, KJ, Dimasi, D, Cockshell, M, Beard, MR, Pitson, SM, Bonder, CS & Carr, JM 2015, 'Dengue virus infection of primary endothelial cells induces innate immune responses, changes in endothelial cells function and is restricted by interferon-stimulated responses', Journal of interferon and cytokine research, vol. 35, no. 8, pp. 654-665.

13 12 1
2015

Canlas, J, Holt, P, Carroll, A, Rix, S, Ryan, P, Davies, L, Matusica, D, Pitson, SM, Jessup, CF, Gibbins, IL & Haberberger, R V 2015, 'Sphingosine kinase 2-deficiency mediated changes in spinal pain processing', Frontiers in Molecular Neuroscience, vol. 8, no. 29, pp. 1-13.

Open access 8 7 1
2015

Etemadi, N, Chopin, M, Anderton, H, Tanzer, MC, Rickard, JA, Abeysekera, W, Hall, C, Spall, SK, Wang, B, Xiong, Y, Hla, T, Pitson, SM, Bonder, CS, Wong, WW-L, Ernst, M, Smyth, GK, Vaux, DL, Nutt, SL, Nachbur, U & Silke, J 2015, 'TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1', eLife, vol. 4, article no. e10592, pp. 1-27.

Open access 29 28 3
2015

Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774.

Open access 13 9 26
2015

Parham, KA, Zebol, JR, Tooley, KL, Sun, WY, Moldenhauer, LM, Cockshell, MP, Gliddon, BL, Moretti, PA, Tigyi, G, Pitson, SM & Bonder, CS 2015, 'Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-Îł that regulates neoangiogenesis', FASEB journal, vol. 29, no. 9, pp. 3638-3653.

Open access 23 20 1
2015

Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083.

Open access 25 20
2015

Woodcock, JM, Coolen, C, Goodwin, KL, Baek, DJ, Bittman, R, Samuel, MS, Pitson, SM & Lopez, AF 2015, 'Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics', OncoTarget, vol. 6, no. 16, pp. 14522-14536.

Open access 14 10
2014

Ceccom, J, Loukh, N, Lauwers-, CV, Touriol, C, Nicaise, Y, Gentil, C, Uro-Coste, E, Pitson, S, Maurage, CA, Duyckaerts, C, Cuvillier, O & Delisle, M-B 2014, 'Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease', Acta neuropathologica communications, vol. 2, pp. 1-10.

Open access 38 39 1
2014

Parham, KA, Pitson, SM & Bonder, CS 2014, 'Regulation of EPCs: The Gateway to Blood Vessel Formation', New journal of science, vol. 2014, article no. 972043, pp. 1-16.

Open access 3
2014

Pham, D, Powell, J, Gliddon, B, Moretti, P, Tsykin, A, Van Der Hoek, M, Kenyon, R, Goodall, G & Pitson, S 2014, 'Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1', Oncogene, vol. 33, no. 48, pp. 5559-5568.

7 12
2014

Wallington-Beddoe, GT, Powell, JA, Tong, D, Pitson, SM, Bradstock, KF & Bendall, LJ 2014, 'Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression', Cancer research, vol. 74, no. 10, pp. 2803-2815.

Open access 35 30 1
2014

Yamane, D, McGivern, DR, Wauthier, E, Yi, M, Pitson, SM & Lemon, SM and 18 other authors 2014, 'Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation', Nature medicine, vol. 20, pp. 927-935.

Open access 74 67 25
2013

Carr, J, Kua, T, Clarke, J, Calvert, J, Zebol, J, Beard, M & Pitson, S 2013, 'Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA', Journal of general virology, vol. 94, part 11, pp. 2437-2448.

16 16
2013

Carr, JM, Mahalingam, S, Bonder, CS & Pitson, SM 2013, 'Sphingosine kinase 1 in viral infections', Reviews in medical virology, vol. 23 no. 2, pp. 73-84.

22 21
2013

Chan, H & Pitson, SM 2013, 'Post-translational regulation of sphingosine kinases', Biochimica et biophysica acta: molecular and cell biology of lipids, vol. 1831, no. 1, pp. 147-156.

19 20
2013

Neubauer, HA & Pitson, SM 2013, 'Roles, regulation and inhibitors of sphingosine kinase 2', The FEBS Journal, vol. 280, no. 21, pp. 5317-5336.

Open access 79 75 4
2013

Thomas, D, Powell, JA, Green, BD, Barry, EF, Ma, Y, Woodcock, J, Fitter, S, Zannettino, AC, Pitson, SM, Hughes, TP, Lopez, AF, Shepherd, PR, Wei, AH, Ekert, PG & Guthridge, MA 2013, 'Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival', PLoS biology, vol. 11, no. 3, article no. e1001515, pp. 1-14.

Open access 14 12 4
2012

Bruce, CR, Risis, S, Babb, JR, Yang, C, Kowalski, GM, Selathurai, A, Lee-Young, RS, Weir, JM, Yoshioka, K, Takuwa, Y, Meikle, PJ, Pitson, SM & Febbraio, MA 2012, 'Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice', Diabetes, vol. 61, no. 12, pp. 3148-3155.

Open access 60 60 3
2012

Hercus, TR, Broughton, SE, Ekert, PG, Ramshaw, HS, Perugini, M, Grimbaldeston, M, Woodcock, JM, Thomas, D, Pitson, S, Hughes, T, D'Andrea, RJ, Parker, MW & Lopez, AF 2012, 'The GM-CSF receptor family: mechanism of activation and implications for disease', Growth factors, vol. 30, no. 2, pp. 63-75.

Open access 31 29 1
2012

Juarez, JG, Harun, N, Thiene, M, Welschinger, R, Baraz, R, Pena, AD, Pitson, SM, Rettig, M, DiPersio, JF, Bradstock, KF & Bendall, LJ 2012, 'Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice', Blood, vol. 119, no. 3, pp. 707-716.

72 66 6
2012

Lim, KG, Tonelli, F, Berdyshev, E, Gorshkova, I, Leclercq, T, Pitson, SM, Bittman, R, Pyne, S & Pyne, NJ 2012, 'Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b', The International Journal of Biochemistry & Cell Biology, vol. 44 no. 9, pp. 1457-1464.

25 25 2
2012

Pitman, M, Woodcock, J, Lopez, A & Pitson, S 2012, 'Molecular targets of FTY720 (Fingolimod)', Current molecular medicine, vol. 12, no. 10, pp. 1207-1219.

42 42
2012

Pitman, MR, Pham, DH & Pitson, SM 2012, 'Isoform-selective assays for sphingosine kinase activity', Methods in molecular biology, vol. 874, pp. 21-31.

25
2012

Sun, WY, Abeynaike, LD, Escarbe, S, Smith, CD, Pitson, SM, Hickey, MJ & Bonder, CS 2012, 'Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent', American journal of pathology, vol. 180, no. 4, pp. 1740-1750.

15 15
2011

Barrett, JM, Parham, KA, Pippal, JB, Cockshell, MP, Moretti, PA, Brice, SL, Pitson, S & Bonder, C 2011, 'Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells', Microcirculation, vol. 18 no. 7, pp. 583-597.

8 9
2011

Cordts, F, Pitson, S, Tabeling, C, Gibbins, I, Moffat, DF, Jersmann, H, Hodge, S & Haberberger, R V 2011, 'Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease', Life Sciences, vol. 89 no. 21-22, pp. 806-811.

20 17
2011

Jessup, CF, Bonder, CS, Pitson, SM & Coates, PTH 2011, 'The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function', Endocrine, metabolic & immune disorders : drug targets, vol. 11, no. 4, pp. 262-272.

17
2011

Leclercq, T, Moretti, PAB & Pitson, SM 2011, 'Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis', Oncogene, vol. 30, no. 3, pp. 372-378.

38 30
2011

Pchejetski, D, Nunes, J, Caughlan, K, Lall, H, Pitson, SM, Waxman, J & Sumbayev, V V 2011, 'The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1a protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6', Immunology and Cell Biology, vol. 89 no. 2, pp. 268-274.

33 36
2011

Pitman, MR, Barr, RK, Gliddon, BL, Magarey, AM, Moretti, PA & Pitson, SM 2011, 'A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1', The international journal of biochemistry and cell biology, vol. 43, no. 3, pp. 342-347.

20 17
2011

Pitson, SM 2011, 'Regulation of sphingosine kinase and sphingolipid signaling', Trends in biochemical sciences, vol. 36 no. 2, pp. 97-107.

178 162
2011

Pitson, SM, Powell, JA & Bonder, CS 2011, 'Regulation of sphingosine kinase in hematological malignancies and other cancers', Anti-cancer agents in medicinal chemistry, vol. 11, no. 9, pp. 799-809.

14 14
2011

Siow, D, Anderson, C, Berdyshev, E, Skobeleva, A, Natarajan, V, Pitson, SM & Wattenberg, B 2011, 'Sphingosine kinase localization in the control of sphingolipid metabolism', Advances in enzyme regulation, vol. 51, no. 1, pp. 229-244.

21 16 6
2011

Wati, S, Rawlinson, SM, Ivanov, RA, Dorstyn, L, Beard, M, Jans, DA, Pitson, S, Burrell, CJ, Li, P & Carr, JM 2011, 'Tumour necrosis factor alpha (TNF-α) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-α to activate nuclear factor kb and reduced sphingosine kinase-1 activity', Journal of general virology, vol. 92 no. 4, pp. 807-818.

30 33
2010

Jarman, KE, Moretti, PA, Zebol, JR & Pitson, SM 2010, 'Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1', Journal of biological chemistry, vol. 285 no. 1, pp. 483-492.

83
2010

Kim, M, Kim, M, Park, SW, Pitson, SM & Thomas Lee, H 2010, 'Isoflurane Protects Human Kidney Proximal Tubule Cells against Necrosis via Sphingosine Kinase and Sphingosine-1-Phosphate Generation', American Journal of Nephrology, vol. 31, no. 4, pp. 353-362.

41 39 1
2010

Loveridge, C, Tonelli, F, Leclercq, T, Lim, K, Long, J, Berdyshev, E, Tate, R, Natarajan, V, Pitson, SM, Pyne, N & Pyne, S 2010, 'The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells', Journal of Biological Chemistry, vol. 285, no. 50, pp. 38841-38852.

76 70 3
2010

Malavaud, B, Pchejetski, D, Mazerolles, C, De Paiva, G, Calvet, C, Doumerc, N, Pitson, SM, Rischmann, P & Cuvillier, O 2010, 'Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens', European Journal of Cancer, vol. 46 no. 18, pp. 3417-3424.

55
2010

Pitman, M & Pitson, SM 2010, 'Inhibitors of the sphingosine kinase pathway as potential therapeutics ', Current Cancer Drug Targets, vol. 10, no. 4, pp. 354-367.

54 53
2010

Siow, D, Anderson, C, Berdyshev, E, Skobeleva, A, Pitson, SM & Wattenberg, B 2010, 'Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1- phosphate', Journal of Lipid Research, vol. 51, no. 9, pp. 2546-2559.

32 30
2010

Song, J, Kim, M, Park, SW, Chen, S, Pitson, SM & Lee, H 2010, 'Isoflurane via TGF-ß1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules', American Journal of Physiology: Renal Physiology, vol. 298, no. 4, pp. 1041-1050.

21 19
2010

Sun, WY, Pitson, SM & Bonder, C 2010, 'Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial a 5ß 1 integrin', American Journal of Pathology, vol. 177 no. 1, pp. 436-446.

24
2010

Tonelli, F, Lim, K, Loveridge, C, Long, J, Pitson, SM, Tigyi, G, Bittman, R, Pyne, S & Pyne, N 2010, 'FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells', Cellular Signalling, vol. 22, no. 10, pp. 1536-1542.

Open access 118 108 3
2010

Williams, S, Milne, I, Bagley, C, Gamble, JR, Vadas, M, Pitson, SM & Khew-Goodall, Y 2010, 'A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration', The Journal of Immunology, vol. 185 no. 5, pp. 3057-3063.

43
2010

Woodcock, J, Ma, Y, Coolen, C, Pham, D, Jones, CA, López-Soto, A & Pitson, SM 2010, 'Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function', Cellular Signalling, vol. 22, no. 9, pp. 1291-1299.

46 43
2009

Bonder, CS, Sun, WY, Matthews, T, Cassano, C, Li, X, Ramshaw, HS, Pitson, SM, Lopez, AF, Coates, PT, Proia, RL, Vadas, MA & Gamble, JR 2009, 'Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation', Blood, vol. 113, no. 9, pp. 2108-2117.

29 26
2009

Gamble, JR, Sun, WY, Li, X, Hahn, CN, Pitson, SM, Vadas, M & Bonder, C 2009, 'Sphingosine kinase-1 associates with integrin aVß 3 to mediate endothelial cell survival', American Journal of Pathology, vol. 175, no. 5, pp. 2217-2225.

14 11
2009

Lidington, D, Peter, B, Meissner, A, Kroetsch, J, Pitson, SM, Pohl, S & Bolz, S-S 2009, 'The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries', Arteriosclerosis Thrombosis and Vascular Biology, vol. 29 no. 11, pp. 1916-1922.

17
2009

Limaye, V, Vadas, M, Pitson, SM & Gamble, JR 2009, 'The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells', Cellular and Molecular Biology Letters: an international journal, vol. 14, no. 3, pp. 411-423.

7 7
2009

Limaye, V, Xia, P, Hahn, CN, Smith, M, Vadas, M, Pitson, SM & Gamble, JR 2009, 'Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells', Cellular and Molecular Biology Letters: an international journal, vol. 14 no. 3, pp. 424-441.

28
2009

Pitson, SM & Pebay, A 2009, 'Regulation of stem cell pluripotency and neural differentiation by lysophospholipids', NeuroSignals, vol. 17, no. 4, pp. 242-254.

42 33
2009

Zebol, JR, Hewitt, NM, Moretti, PA, Lynn, HE, Lake, JA, Li, P, Vadas, MA, Wattenberg, BW & Pitson, SM 2009, 'The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1', The International journal of biochemistry & cell biology, vol. 41 no. 4, pp. 822-827.

Open access 14 10
2009

ter Braak, M, K, Lichte, K, Liphardt, K, Ktistakis, N, Pitson, SM, Hla, T, Jakobs, K & Heringdorf, D 2009, 'Gaq-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors', BBA - Molecular and Cell Biology of Lipids, vol. 1791, no. 5, pp. 357-370.

19 17
2008

Barr, R, Lynn, H, Moretti, PAB, Khew-Goodall, Y & Pitson, SM 2008, 'Deactivation of sphingosine kinase 1 by protein phosphatase 2A', Journal of Biological Chemistry, vol. 283, no. 50, pp. 34994-35002.

40 32
2008

Leclercq, T, Moretti, PAB, Vadas, M & Pitson, SM 2008, 'Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity', Journal of Biological Chemistry, vol. 283, no. 15, pp. 9606-9614.

40 37 3
2008

Li, X, Stankovic, M, Bonder, C, Hahn, CN, Parsons, M, Pitson, SM, Xia, P, Proia, RL, Vadas, M & Gamble, JR 2008, 'Basal and angiopoietin-1 mediated endothelial permeability is regulated by sphingosine kinase-1', Blood, vol. 111 no. 7, pp. 3489-3497.

66
2008

Pham, D, Moretti, PAB, Goodall, G & Pitson, SM 2008, 'Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements', BioTechniques: the journal of laboratory technology for bioresearch, vol. 45 no. 2, pp. 155-162.

15
2008

Pitson, SM, Goodall, G & Guthridge, MA 2008, 'Science amongst the vines. Meeting on Signalling Systems', EMBO Reports, vol. 9 no. 5, pp. 425-428.

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Modulators of 14-3-3 functionality and uses thereof

Woodcock, Joanna; Lopez, Angel; Pitson, Stuart; Samuel, Michael; Coolen, Carl

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Organisation Country
Australian National University AUSTRALIA
Babraham Institute UNITED KINGDOM
Baker Heart and Diabetes Institute AUSTRALIA
Central Adelaide Local Health Network Incorporated AUSTRALIA
Central Queensland University AUSTRALIA
Charité - Universitätsmedizin Berlin GERMANY
City University of New York UNITED STATES
Columbia University UNITED STATES
Cornell University UNITED STATES
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation) AUSTRALIA
Flinders University AUSTRALIA
Garvan Medical Institute AUSTRALIA
Griffith University AUSTRALIA
Hanson Centre for Cancer Research AUSTRALIA
Hanson Institute AUSTRALIA
Imperial College of Science, Technology and Medicine UNITED KINGDOM
Institute of Medical and Veterinary Science AUSTRALIA
Jilin University CHINA
Kanazawa University JAPAN
La Trobe University AUSTRALIA
Medical University of Innsbruck AUSTRIA
Medical University of South Carolina UNITED STATES
Monash University AUSTRALIA
National Institutes of Health UNITED STATES
New York University UNITED STATES
QIMR Berghofer Medical Research Institute AUSTRALIA
Queen Elizabeth Hospital AUSTRALIA
Royal Adelaide Hospital AUSTRALIA
SA Pathology AUSTRALIA
Shanghai University CHINA
South Australian Health and Medical Research Institute (SAHMRI) AUSTRALIA
St. Vincent's Institute of Medical Research AUSTRALIA
Stanford University UNITED STATES
The Alfred Hospital AUSTRALIA
The Kinghorn Cancer Centre AUSTRALIA
University of Adelaide AUSTRALIA
University of Auckland NEW ZEALAND
University of Chicago UNITED STATES
University of Connecticut UNITED STATES
University of Essen GERMANY
University of Illinois at Chicago UNITED STATES
University of Kent UNITED KINGDOM
University of Louisville UNITED STATES
University of Melbourne AUSTRALIA
University of New South Wales AUSTRALIA
University of North Carolina at Chapel Hill UNITED STATES
University of Queensland AUSTRALIA
University of South Australia AUSTRALIA
University of Strathclyde UNITED KINGDOM
University of Sydney AUSTRALIA
University of Tennessee UNITED STATES
University of Texas UNITED STATES
University of Toronto CANADA
University of Toulouse - Jean Jaures FRANCE
University of Toulouse Iii Paul Sabatier FRANCE
University of Zurich SWITZERLAND
Walter and Eliza Hall Institute of Medical Research AUSTRALIA
Washington University UNITED STATES
Westmead Hospital AUSTRALIA
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Engagement/recognition Year

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2017

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2016

Project Grant

National Health and Medical Research Council (NHMRC)

2016

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2015

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2014

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2013

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2012

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2011

NHMRC Senior Research Fellow

Institute of Medical and Veterinary Science (IMVS)

2010
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Research degree supervision

Supervisions from 2010 shown

Thesis title Student status
Investigating rho-rock signalling pathway contribution to mammary tumorigenesis Current
Targeting multiple myeloma by manipulation of sphingolipid metabolism Current
Targeting sphingosine kinase 1 (SK1) in acute myeloid leukaemia (AML) Current
Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis. Current
Peroxisome proliferator-activated receptor gamma interacts with sphingosine 1-phosphate to regulate vascular function Completed
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Professor Stuart Pitson
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