Professor Stuart Pitson

Research Professor Centre for Cancer Biology

City West Campus (HB10-11)
tel +61 8 830 27832

email Stuart.Pitson@unisa.edu.au

Research Degree Supervisor

About me

Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Orcid
Scopus

Research

Research themes

Cancer

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Biological Sciences
Medical and Health Sciences
Oncology and Carcinogenesis

Research

Projects

Excludes commercial-in-confidence projects.

Targeting sphingolipid metabolism in disease, NHMRC - Senior Principal Research Fellowship, 01/01/2019 - 31/12/2023
Targeting sphingosine kinase 1 to sensitise acute myeloid leukaemia to BH3 mimetic therapy, NHMRC - Project Grant, 01/01/2018 - 31/12/2020
Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/05/2019
Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Sphingosine kinase as a target for anti-cancer therapy, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/03/2018
Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer, NHMRC - Project Grant, 01/01/2015 - 31/12/2017
Targeting sphingosine kinases to improve glioblastoma therapy, Neurosurgical Research Foundation, 21/06/2016 - 30/09/2017
Targeting Sphingosine Kinase 1C Degradation to Enhance Chemosensitivity', Central Adelaide Local Health Network Incorporated, 01/01/2016 - 30/06/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
Liquid handling robot and cell analysis systems, Neurosurgical Research Foundation, 17/10/2016 - 30/05/2017
Enhancing wound healing via modulation of the sphingosine kinase/ sphingosine 1-phosphate pathway, Royal Adelaide Hospital, 12/02/2015 - 28/02/2016
Targeting sphingosine kinase 1c degradation to enhance cancer chemotherapeutic sensitivity, Cancer Council SA - Beat Cancer, 01/01/2015 - 31/12/2015
Roles and regulations of sphingosine kinase 1 during dengue virus infection, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
A new target for allergic inflammation: the sphingolipid pathway, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
Targetting the CIB1-sphingosine kinase interaction in oncogenesis, NHMRC - Project Grant, 01/01/2014 - 30/04/2015
Characterising a highly oncogenic variant of sphingosine kinase 1, Cancer Council SA - Beat Cancer, 01/01/2014 - 31/12/2014

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2018	Pitman, MR, Davies, LT & Pitson, SM 2018, 'An improved isoform-selective assay for sphingosine kinase 1 activity', in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate, Humana Press, Inc., US, ch. 2, pp. 9-20. 1
2013	Pitman, MR, Jarman, K, Leclercq, T, Pham, D & Pitson, SM 2013, 'Sphingosine kinases: biochemistry, regulation, and roles', in J Chun et al. (eds), Lysophospholipid Receptors: Signaling and Biochemistry, Wiley-Blackwell, US, ch. 9, pp. 153-183. 1 2

Journal Articles

Year	Output
2018	Lidgerwood, GE, Pitson, SM, Bonder, C & Pébay, A 2018, 'Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology', Progress in lipid research, vol. 72, pp. 42-54.
2018	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2018, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, online, pp. 1-15. Open access
2018	Poltavets, V, Kochetkova, M, Pitson, SM & Samuel, MS 2018, 'The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity', Frontiers in oncology, vol. 8, article no. 431, pp. 1-19. Open access 1
2018	Wallington-Beddoe, CT, Sobieraj-Teague, M, Kuss, BJ & Pitson, SM 2018, 'Resistance to proteasome inhibitors and other targeted therapies in myeloma', British journal of haematology, vol. 182, pp. 11-28. 4 4 5
2018	Wallington-Beddoe, CT, Xie, V, Tong, D, Powell, JA, Lewis, AC, Davies, L, Pitson, SM, Bradstock, KF & Bendall, LJ 2018, 'Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia', British journal of haematology, online, pp. 1-4. 1
2018	Woodcock, JM, Goodwin, KL, Sandow, JJ, Coolen, C, Perugini, MA, Webb, A I, Pitson, SM, Lopez, AF & Carver, JA 2018, 'Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity', Journal of biological chemistry, vol. 293, no. 1, pp. 89-99. Open access 1 1 3
2017	Al-Shujairi, WH, Clarke, JN, Davies, LT, Alsharifi, M, Pitson, SM & Carr, JM 2017, 'Intracranial injection of dengue virus induces interferon stimulated genes and CD8+ T cell infiltration by sphingosine kinase 1 independent pathways', PLoS one, vol. 12, article no. e0169814, pp. 1-21. Open access 1 1 1
2017	Aloia, AL, Calvert, JK, Clarke, JN, Davies, LT, Helbig, KJ, Pitson, SM & Carr, JM 2017, 'Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection', Clinical & translational immunology, vol. 6, no. 7, article no. e151, pp. 1-9. Open access 2 1
2017	Hein, N, Cameron, DP, Hannan, KM, Nguyen, N-Y, Powell, JA, Pitson, SM & Hannan, RD and 23 other authors 2017, 'Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population', Blood, vol. 129, pp. 2882-2895. 7 6 62
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. 13 12 85
2017	Rojas-Canales, D, Penko, D, Myo Min, KK, Parham, KA, Peiris, H, Haberberger, R V, Pitson, SM, Drogemuller, C, Keating, DJ, Grey, ST, Coates, PT, Bonder, CS & Jessup, CF 2017, 'Local sphingosine kinase 1 activity improves islet transplantation', Diabetes, vol. 66, no. 5, pp. 1301-1311. Open access 1 2 6
2017	Tran, HB, Jersmann, H, Truong, TT, Hamon, R, Roscioli, E, Ween, M, Pitman, MR, Pitson, SM, Hodge, G, Reynolds, PN & Hodge, S 2017, 'Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD', PLoS one, vol.12, no. 11, pp. 1-14. Open access 4 3 1
2017	Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616. Open access 7 8 8
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. 9 7
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 8 6 2
2016	Aurelio, L, Scullino, C V, Pitman, MR, Sexton, A, Oliver, V, Davies, L, Rebello, RJ, Furic, L, Creek, DJ, Pitson, SM & Flynn, BL 2016, 'From sphingosine kinase to dihydroceramide desaturase: A structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)', Journal of Medicinal Chemistry, vol. 59, pp. 965-984. 11 12
2016	Clarke, JN, Davies, LK, Calvert, JK, Gliddon, BL, Al, SWH, Aloia, AL, Helbig, KJ, Beard, MR, Pitson, SM & Carr, JM 2016, 'Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses', Journal of General Virology, vol. 97, no. 1, pp. 95-109. Open access 11 11 1
2016	Dimasi, DP, Pitson, SM & Bonder, CS 2016, 'Examining the role of sphingosine kinase-2 in the regulation of endothelial cell barrier integrity', Microcirculation, vol. 23, no. 3, pp. 248-265. Open access 4 4
2016	McNaughton, M, Pitman, M, Pitson, SM, Pyne, NJ & Pyne, S 2016, 'Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells', Oncotarget, vol. 7, no. 13, pp. 16663-16675. Open access 31 26
2016	Neubauer, HA & Pitson, SM 2016, 'Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence', F1000Research, vol. 5, article no. 2825 , pp. 1-12. Open access 2
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 12 9
2016	Pitman, MR, Costabile, M & Pitson, SM 2016, 'Recent advances in the development of sphingosine kinase inhibitors', Cellular signalling, vol. 28, no. 9, pp. 1349-1363. Open access 24 25
2016	Schoenwaelder, SM, Darbousset, R, Cranmer, SL, Ramshaw, HS, Woodcock, J, Pitson, S, Lopez, AF & Jackson, SP and 13 other authors 2016, '14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function', Nature communications, vol. 7, article no. 12862, pp. 1-15. Open access 16 14 1
2016	Sun, WY, Dimasi, DP, Pitman, MR, Zhuang, Y, Heddle, R, Pitson, SM, Grimbaldeston, MA & Bonder, CS 2016, 'Topical application of fingolimod perturbs cutaneous inflammation', Journal of immunology, vol. 196, no. 9, pp. 3854-3864. 9 7 1
2016	Tran, HB, Barnawi, J, Ween, M, Hamon, R, Roscioli, E, Hodge, G, Reynolds, PN, Pitson, SM, Davies, LT, Haberberger, R & Hodge, S 2016, 'Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720', Journal of leukocyte biology, vol. 100, no.1, pp. 195-202. 10 7 1
2015	Aloia, AL, Abraham, AM, Bonder, CS, Pitson, SM & Carr, JM 2015, 'Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs', Mediators of Inflammation, vol. 2015, article no. 509306, pp. 1-13. Open access 7 4 2
2015	Barnawi, J, Tran, H, Jersmann, H, Pitson, SM, Roscioli, E, Hodge, G, Meech, R, Haberberger, R & Hodge, S 2015, 'Potential link between the sphingosine-1-phosphate (S1P) system and defective alveolar macrophage phagocytic function in chronic obstructive pulmonary disease (COPD)', PLoS one, vol. 10, no. 10, article no. e0122771. Open access 16 14
2015	Beroukas, D, Selhorst, M, Pitson, SM, Matusica, D, Gibbins, IL, Kress, M & Haberberger, R V 2015, 'Sphingosine kinase 1 in murine dorsal root ganglia', AIMS Molecular Science, vol. 2, no. 1, pp. 22-33. Open access 1
2015	Calvert, JK, Helbig, KJ, Dimasi, D, Cockshell, M, Beard, MR, Pitson, SM, Bonder, CS & Carr, JM 2015, 'Dengue virus infection of primary endothelial cells induces innate immune responses, changes in endothelial cells function and is restricted by interferon-stimulated responses', Journal of interferon and cytokine research, vol. 35, no. 8, pp. 654-665. 13 12 1
2015	Canlas, J, Holt, P, Carroll, A, Rix, S, Ryan, P, Davies, L, Matusica, D, Pitson, SM, Jessup, CF, Gibbins, IL & Haberberger, R V 2015, 'Sphingosine kinase 2-deficiency mediated changes in spinal pain processing', Frontiers in Molecular Neuroscience, vol. 8, no. 29, pp. 1-13. Open access 8 7 1
2015	Etemadi, N, Chopin, M, Anderton, H, Tanzer, MC, Rickard, JA, Abeysekera, W, Hall, C, Spall, SK, Wang, B, Xiong, Y, Hla, T, Pitson, SM, Bonder, CS, Wong, WW-L, Ernst, M, Smyth, GK, Vaux, DL, Nutt, SL, Nachbur, U & Silke, J 2015, 'TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1', eLife, vol. 4, article no. e10592, pp. 1-27. Open access 29 28 3
2015	Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774. Open access 13 9 26
2015	Parham, KA, Zebol, JR, Tooley, KL, Sun, WY, Moldenhauer, LM, Cockshell, MP, Gliddon, BL, Moretti, PA, Tigyi, G, Pitson, SM & Bonder, CS 2015, 'Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis', FASEB journal, vol. 29, no. 9, pp. 3638-3653. Open access 23 20 1
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 25 20
2015	Woodcock, JM, Coolen, C, Goodwin, KL, Baek, DJ, Bittman, R, Samuel, MS, Pitson, SM & Lopez, AF 2015, 'Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics', OncoTarget, vol. 6, no. 16, pp. 14522-14536. Open access 14 10
2014	Ceccom, J, Loukh, N, Lauwers-, CV, Touriol, C, Nicaise, Y, Gentil, C, Uro-Coste, E, Pitson, S, Maurage, CA, Duyckaerts, C, Cuvillier, O & Delisle, M-B 2014, 'Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease', Acta neuropathologica communications, vol. 2, pp. 1-10. Open access 38 39 1
2014	Parham, KA, Pitson, SM & Bonder, CS 2014, 'Regulation of EPCs: The Gateway to Blood Vessel Formation', New journal of science, vol. 2014, article no. 972043, pp. 1-16. Open access 3
2014	Pham, D, Powell, J, Gliddon, B, Moretti, P, Tsykin, A, Van Der Hoek, M, Kenyon, R, Goodall, G & Pitson, S 2014, 'Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1', Oncogene, vol. 33, no. 48, pp. 5559-5568. 7 12
2014	Wallington-Beddoe, GT, Powell, JA, Tong, D, Pitson, SM, Bradstock, KF & Bendall, LJ 2014, 'Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression', Cancer research, vol. 74, no. 10, pp. 2803-2815. Open access 35 30 1
2014	Yamane, D, McGivern, DR, Wauthier, E, Yi, M, Pitson, SM & Lemon, SM and 18 other authors 2014, 'Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation', Nature medicine, vol. 20, pp. 927-935. Open access 74 67 25
2013	Carr, J, Kua, T, Clarke, J, Calvert, J, Zebol, J, Beard, M & Pitson, S 2013, 'Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA', Journal of general virology, vol. 94, part 11, pp. 2437-2448. 16 16
2013	Carr, JM, Mahalingam, S, Bonder, CS & Pitson, SM 2013, 'Sphingosine kinase 1 in viral infections', Reviews in medical virology, vol. 23 no. 2, pp. 73-84. 22 21
2013	Chan, H & Pitson, SM 2013, 'Post-translational regulation of sphingosine kinases', Biochimica et biophysica acta: molecular and cell biology of lipids, vol. 1831, no. 1, pp. 147-156. 19 20
2013	Neubauer, HA & Pitson, SM 2013, 'Roles, regulation and inhibitors of sphingosine kinase 2', The FEBS Journal, vol. 280, no. 21, pp. 5317-5336. Open access 79 75 4
2013	Thomas, D, Powell, JA, Green, BD, Barry, EF, Ma, Y, Woodcock, J, Fitter, S, Zannettino, AC, Pitson, SM, Hughes, TP, Lopez, AF, Shepherd, PR, Wei, AH, Ekert, PG & Guthridge, MA 2013, 'Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival', PLoS biology, vol. 11, no. 3, article no. e1001515, pp. 1-14. Open access 14 12 4
2012	Bruce, CR, Risis, S, Babb, JR, Yang, C, Kowalski, GM, Selathurai, A, Lee-Young, RS, Weir, JM, Yoshioka, K, Takuwa, Y, Meikle, PJ, Pitson, SM & Febbraio, MA 2012, 'Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice', Diabetes, vol. 61, no. 12, pp. 3148-3155. Open access 60 60 3
2012	Hercus, TR, Broughton, SE, Ekert, PG, Ramshaw, HS, Perugini, M, Grimbaldeston, M, Woodcock, JM, Thomas, D, Pitson, S, Hughes, T, D'Andrea, RJ, Parker, MW & Lopez, AF 2012, 'The GM-CSF receptor family: mechanism of activation and implications for disease', Growth factors, vol. 30, no. 2, pp. 63-75. Open access 31 29 1
2012	Juarez, JG, Harun, N, Thiene, M, Welschinger, R, Baraz, R, Pena, AD, Pitson, SM, Rettig, M, DiPersio, JF, Bradstock, KF & Bendall, LJ 2012, 'Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice', Blood, vol. 119, no. 3, pp. 707-716. 72 66 6
2012	Lim, KG, Tonelli, F, Berdyshev, E, Gorshkova, I, Leclercq, T, Pitson, SM, Bittman, R, Pyne, S & Pyne, NJ 2012, 'Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b', The International Journal of Biochemistry & Cell Biology, vol. 44 no. 9, pp. 1457-1464. 25 25 2
2012	Pitman, M, Woodcock, J, Lopez, A & Pitson, S 2012, 'Molecular targets of FTY720 (Fingolimod)', Current molecular medicine, vol. 12, no. 10, pp. 1207-1219. 42 42
2012	Pitman, MR, Pham, DH & Pitson, SM 2012, 'Isoform-selective assays for sphingosine kinase activity', Methods in molecular biology, vol. 874, pp. 21-31. 25
2012	Sun, WY, Abeynaike, LD, Escarbe, S, Smith, CD, Pitson, SM, Hickey, MJ & Bonder, CS 2012, 'Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent', American journal of pathology, vol. 180, no. 4, pp. 1740-1750. 15 15
2011	Barrett, JM, Parham, KA, Pippal, JB, Cockshell, MP, Moretti, PA, Brice, SL, Pitson, S & Bonder, C 2011, 'Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells', Microcirculation, vol. 18 no. 7, pp. 583-597. 8 9
2011	Cordts, F, Pitson, S, Tabeling, C, Gibbins, I, Moffat, DF, Jersmann, H, Hodge, S & Haberberger, R V 2011, 'Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease', Life Sciences, vol. 89 no. 21-22, pp. 806-811. 20 17
2011	Jessup, CF, Bonder, CS, Pitson, SM & Coates, PTH 2011, 'The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function', Endocrine, metabolic & immune disorders : drug targets, vol. 11, no. 4, pp. 262-272. 17
2011	Leclercq, T, Moretti, PAB & Pitson, SM 2011, 'Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis', Oncogene, vol. 30, no. 3, pp. 372-378. 38 30
2011	Pchejetski, D, Nunes, J, Caughlan, K, Lall, H, Pitson, SM, Waxman, J & Sumbayev, V V 2011, 'The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1a protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6', Immunology and Cell Biology, vol. 89 no. 2, pp. 268-274. 33 36
2011	Pitman, MR, Barr, RK, Gliddon, BL, Magarey, AM, Moretti, PA & Pitson, SM 2011, 'A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1', The international journal of biochemistry and cell biology, vol. 43, no. 3, pp. 342-347. 20 17
2011	Pitson, SM 2011, 'Regulation of sphingosine kinase and sphingolipid signaling', Trends in biochemical sciences, vol. 36 no. 2, pp. 97-107. 178 162
2011	Pitson, SM, Powell, JA & Bonder, CS 2011, 'Regulation of sphingosine kinase in hematological malignancies and other cancers', Anti-cancer agents in medicinal chemistry, vol. 11, no. 9, pp. 799-809. 14 14
2011	Siow, D, Anderson, C, Berdyshev, E, Skobeleva, A, Natarajan, V, Pitson, SM & Wattenberg, B 2011, 'Sphingosine kinase localization in the control of sphingolipid metabolism', Advances in enzyme regulation, vol. 51, no. 1, pp. 229-244. 21 16 6
2011	Wati, S, Rawlinson, SM, Ivanov, RA, Dorstyn, L, Beard, M, Jans, DA, Pitson, S, Burrell, CJ, Li, P & Carr, JM 2011, 'Tumour necrosis factor alpha (TNF-α) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-α to activate nuclear factor kb and reduced sphingosine kinase-1 activity', Journal of general virology, vol. 92 no. 4, pp. 807-818. 30 33
2010	Jarman, KE, Moretti, PA, Zebol, JR & Pitson, SM 2010, 'Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1', Journal of biological chemistry, vol. 285 no. 1, pp. 483-492. 83
2010	Kim, M, Kim, M, Park, SW, Pitson, SM & Thomas Lee, H 2010, 'Isoflurane Protects Human Kidney Proximal Tubule Cells against Necrosis via Sphingosine Kinase and Sphingosine-1-Phosphate Generation', American Journal of Nephrology, vol. 31, no. 4, pp. 353-362. 41 39 1
2010	Loveridge, C, Tonelli, F, Leclercq, T, Lim, K, Long, J, Berdyshev, E, Tate, R, Natarajan, V, Pitson, SM, Pyne, N & Pyne, S 2010, 'The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells', Journal of Biological Chemistry, vol. 285, no. 50, pp. 38841-38852. 76 70 3
2010	Malavaud, B, Pchejetski, D, Mazerolles, C, De Paiva, G, Calvet, C, Doumerc, N, Pitson, SM, Rischmann, P & Cuvillier, O 2010, 'Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens', European Journal of Cancer, vol. 46 no. 18, pp. 3417-3424. 55
2010	Pitman, M & Pitson, SM 2010, 'Inhibitors of the sphingosine kinase pathway as potential therapeutics ', Current Cancer Drug Targets, vol. 10, no. 4, pp. 354-367. 54 53
2010	Siow, D, Anderson, C, Berdyshev, E, Skobeleva, A, Pitson, SM & Wattenberg, B 2010, 'Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1- phosphate', Journal of Lipid Research, vol. 51, no. 9, pp. 2546-2559. 32 30
2010	Song, J, Kim, M, Park, SW, Chen, S, Pitson, SM & Lee, H 2010, 'Isoflurane via TGF-ß1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules', American Journal of Physiology: Renal Physiology, vol. 298, no. 4, pp. 1041-1050. 21 19
2010	Sun, WY, Pitson, SM & Bonder, C 2010, 'Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial a 5ß 1 integrin', American Journal of Pathology, vol. 177 no. 1, pp. 436-446. 24
2010	Tonelli, F, Lim, K, Loveridge, C, Long, J, Pitson, SM, Tigyi, G, Bittman, R, Pyne, S & Pyne, N 2010, 'FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells', Cellular Signalling, vol. 22, no. 10, pp. 1536-1542. Open access 118 108 3
2010	Williams, S, Milne, I, Bagley, C, Gamble, JR, Vadas, M, Pitson, SM & Khew-Goodall, Y 2010, 'A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration', The Journal of Immunology, vol. 185 no. 5, pp. 3057-3063. 43
2010	Woodcock, J, Ma, Y, Coolen, C, Pham, D, Jones, CA, López-Soto, A & Pitson, SM 2010, 'Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function', Cellular Signalling, vol. 22, no. 9, pp. 1291-1299. 46 43
2009	Bonder, CS, Sun, WY, Matthews, T, Cassano, C, Li, X, Ramshaw, HS, Pitson, SM, Lopez, AF, Coates, PT, Proia, RL, Vadas, MA & Gamble, JR 2009, 'Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation', Blood, vol. 113, no. 9, pp. 2108-2117. 29 26
2009	Gamble, JR, Sun, WY, Li, X, Hahn, CN, Pitson, SM, Vadas, M & Bonder, C 2009, 'Sphingosine kinase-1 associates with integrin aVß 3 to mediate endothelial cell survival', American Journal of Pathology, vol. 175, no. 5, pp. 2217-2225. 14 11
2009	Lidington, D, Peter, B, Meissner, A, Kroetsch, J, Pitson, SM, Pohl, S & Bolz, S-S 2009, 'The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries', Arteriosclerosis Thrombosis and Vascular Biology, vol. 29 no. 11, pp. 1916-1922. 17
2009	Limaye, V, Vadas, M, Pitson, SM & Gamble, JR 2009, 'The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells', Cellular and Molecular Biology Letters: an international journal, vol. 14, no. 3, pp. 411-423. 7 7
2009	Limaye, V, Xia, P, Hahn, CN, Smith, M, Vadas, M, Pitson, SM & Gamble, JR 2009, 'Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells', Cellular and Molecular Biology Letters: an international journal, vol. 14 no. 3, pp. 424-441. 28
2009	Pitson, SM & Pebay, A 2009, 'Regulation of stem cell pluripotency and neural differentiation by lysophospholipids', NeuroSignals, vol. 17, no. 4, pp. 242-254. 42 33
2009	Zebol, JR, Hewitt, NM, Moretti, PA, Lynn, HE, Lake, JA, Li, P, Vadas, MA, Wattenberg, BW & Pitson, SM 2009, 'The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1', The International journal of biochemistry & cell biology, vol. 41 no. 4, pp. 822-827. Open access 14 10
2009	ter Braak, M, K, Lichte, K, Liphardt, K, Ktistakis, N, Pitson, SM, Hla, T, Jakobs, K & Heringdorf, D 2009, 'Gaq-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors', BBA - Molecular and Cell Biology of Lipids, vol. 1791, no. 5, pp. 357-370. 19 17
2008	Barr, R, Lynn, H, Moretti, PAB, Khew-Goodall, Y & Pitson, SM 2008, 'Deactivation of sphingosine kinase 1 by protein phosphatase 2A', Journal of Biological Chemistry, vol. 283, no. 50, pp. 34994-35002. 40 32
2008	Leclercq, T, Moretti, PAB, Vadas, M & Pitson, SM 2008, 'Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity', Journal of Biological Chemistry, vol. 283, no. 15, pp. 9606-9614. 40 37 3
2008	Li, X, Stankovic, M, Bonder, C, Hahn, CN, Parsons, M, Pitson, SM, Xia, P, Proia, RL, Vadas, M & Gamble, JR 2008, 'Basal and angiopoietin-1 mediated endothelial permeability is regulated by sphingosine kinase-1', Blood, vol. 111 no. 7, pp. 3489-3497. 66
2008	Pham, D, Moretti, PAB, Goodall, G & Pitson, SM 2008, 'Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements', BioTechniques: the journal of laboratory technology for bioresearch, vol. 45 no. 2, pp. 155-162. 15
2008	Pitson, SM, Goodall, G & Guthridge, MA 2008, 'Science amongst the vines. Meeting on Signalling Systems', EMBO Reports, vol. 9 no. 5, pp. 425-428.

Research

Patents

Details	Registry	Status
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart; Samuel, Michael; Coolen, Carl	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Australian National University	AUSTRALIA
Babraham Institute	UNITED KINGDOM
Baker Heart and Diabetes Institute	AUSTRALIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Central Queensland University	AUSTRALIA
Charité - Universitätsmedizin Berlin	GERMANY
City University of New York	UNITED STATES
Columbia University	UNITED STATES
Cornell University	UNITED STATES
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Flinders University	AUSTRALIA
Garvan Medical Institute	AUSTRALIA
Griffith University	AUSTRALIA
Hanson Centre for Cancer Research	AUSTRALIA
Hanson Institute	AUSTRALIA
Imperial College of Science, Technology and Medicine	UNITED KINGDOM
Institute of Medical and Veterinary Science	AUSTRALIA
Jilin University	CHINA
Kanazawa University	JAPAN
La Trobe University	AUSTRALIA
Medical University of Innsbruck	AUSTRIA
Medical University of South Carolina	UNITED STATES
Monash University	AUSTRALIA
National Institutes of Health	UNITED STATES
New York University	UNITED STATES
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Shanghai University	CHINA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
The Alfred Hospital	AUSTRALIA
The Kinghorn Cancer Centre	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Chicago	UNITED STATES
University of Connecticut	UNITED STATES
University of Essen	GERMANY
University of Illinois at Chicago	UNITED STATES
University of Kent	UNITED KINGDOM
University of Louisville	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Strathclyde	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Tennessee	UNITED STATES
University of Texas	UNITED STATES
University of Toronto	CANADA
University of Toulouse - Jean Jaures	FRANCE
University of Toulouse Iii Paul Sabatier	FRANCE
University of Zurich	SWITZERLAND
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Washington University	UNITED STATES
Westmead Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2017
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2016
Project Grant National Health and Medical Research Council (NHMRC)	2016
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2015
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2014
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2013
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2012
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2011
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2010

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Investigating rho-rock signalling pathway contribution to mammary tumorigenesis	Current
Targeting multiple myeloma by manipulation of sphingolipid metabolism	Current
Targeting sphingosine kinase 1 (SK1) in acute myeloid leukaemia (AML)	Current
Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis.	Current
Peroxisome proliferator-activated receptor gamma interacts with sphingosine 1-phosphate to regulate vascular function	Completed

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Professor Stuart Pitson

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Projects

Outputs

Chapters

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

Project Grant

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

Teaching & student supervision

Courses and programs

Research degree supervision

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