Dr Tessa Gargett

Adjunct Senior Research Fellow Centre for Cancer Biology

email Tessa.Gargett@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Immunology
Biochemistry and Cell Biology
Biological Sciences
Pharmacology and Pharmaceutical Sciences
Agricultural and Veterinary Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Gargett, T & Ebert, LM 2024, 'Striking an alliance between T cells and macrophages for enhanced cancer immunotherapy', Immunology and Cell Biology, vol. 102, no. 7, pp. 535-537.
2024	Gargett, T, Truong, NT, Gardam, B, Yu, W, Ebert, LM, Johnson, A, Yeo, EC, Wittwer, NL, Tapia Rico, G, Logan, J, Sivaloganathan, P, Collis, M, Ruszkiewicz, A & Brown, MP 2024, 'Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers', Journal for ImmunoTherapy of Cancer, vol. 12, no. 5, pp. 1-17. Open access 4
2024	Yu, W, Truong, NT, Polara, R, Gargett, T, Tea, MN, Pitson, SM, Cockshell, MP, Bonder, CS, Ebert, LM & Brown, MP 2024, 'Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma', Clinical and Translational Immunology, vol. 13, no. 7, pp. 1-20. Open access 1 1 4
2023	Gardam, B, Gargett, T, Brown, MP & Ebert, LM 2023, 'Targeting the dendritic cell-T cell axis to develop effective immunotherapies for glioblastoma', Frontiers in Immunology, vol. 14, pp. 1-14. Open access 5 4
2023	Yu, W, Gargett, T & Du, Z 2023, 'A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of aging', Aging, vol. 15, no. 17, pp. 8537-8551. Open access 1
2022	Alizadeh-Ghodsi, M, Owen, KL, Townley, SL, Zanker, D, Toubia, J, Gargett, T, Thierry, B & Selth, LA and 17 other authors 2022, 'Potent stimulation of the androgen receptor instigates a viral mimicry response in prostate cancer', Cancer Research Communications, vol. 2, no. 7, pp. 706-724. Open access 7 6 15
2022	Gargett, T, Ebert, LM, Truong, NT, Kollis, PM, Sedivakova, K, Yu, W, Yeo, EC, Wittwer, NL, Gliddon, BL, Tea, MN, Ormsby, R, Poonnoose, S, Nowicki, J, Vittorio, O, Ziegler, DS, Pitson, SM & Brown, MP 2022, 'GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma', Journal for ImmunoTherapy of Cancer, vol. 10, no. 9, article no. e005187, pp. 1-15. Open access 50 48
2022	Kollis, PM, Ebert, LM, Toubia, J, Bastow, CR, Ormsby, RJ, Poonnoose, S I, Lenin, S, Tea, MN, Pitson, SM, Gomez, GA, Brown, MP & Gargett, T 2022, 'Characterising distinct migratory profiles of infiltrating T-Cell subsets in human glioblastoma', Frontiers in Immunology, vol.13, pp. 1-19. Open access 16 13
2021	Truong, NT, Gargett, T, Brown, MP & Ebert, LM 2021, 'Effects of chemotherapy agents on circulating leukocyte populations: potential implications for the success of car-t cell therapies', Cancers, vol. 13, no. 9, article no. 2225, pp. 1-19. Open access 26 21
2021	Yeo, EC, Brown, MP, Gargett, T & Ebert, LM 2021, 'The role of cytokines and chemokines in shaping the immune microenvironment of glioblastoma: implications for immunotherapy', Cells, vol. 10, no. 3, article no. 607. Open access 43 39
2020	Ebert, LM, Yu, W, Gargett, T, Toubia, J, Kollis, PM, Tea, MN, Ebert, BW, Bonder, CS, Oksdath Mansilla, M, Scheer, KG, Perrin, SL, Pitson, SM, Gomez, GA & Brown, MP and 8 other authors 2020, 'Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy', Clinical and Translational Immunology, vol. 9, no. 10, article no. e1191. Open access 46 41 4
2019	Brown, MP, Ebert, LM & Gargett, T 2019, 'Clinical chimeric antigen receptor-T cell therapy: a new and promising treatment modality for glioblastoma', Clinical and Translational Immunology, vol. 8, no. 5, article no. e1050, pp. 1-20. Open access 32 31
2019	Gargett, T, Truong, N, Ebert, LM, Yu, W & Brown, MP 2019, 'Optimization of manufacturing conditions for chimeric antigen receptor T cells to favor cells with a central memory phenotype', Cytotherapy, vol. 21, no. 5, pp. 593-602. 28 28
2019	Mencel, J, Gargett, T, Karanth, N, Pokorny, A, Brown, MP & Charakidis, M 2019, 'Thymic hyperplasia following double immune checkpoint inhibitor therapy in two patients with stage IV melanoma', Asia Pacific Journal of Clinical Oncology, vol. 15, no. 6, pp. 383-386. 4 3
2019	Zhang, P, Raju, J, Ullah, MA, Au, R, Gargett, T, Brown, MP & Tey, SK 22 total authors 2019, 'Phase I trial of inducible caspase 9 T cells in adult stem cell transplant demonstrates massive clonotypic proliferative potential and long-term persistence of transgenic T cells', Clinical Cancer Research, vol. 25, no. 6, pp. 1749-1755. Open access 17 18
2018	Ebert, LM, Yu, W, Gargett, T & Brown, MP 2018, 'Logic-gated approaches to extend the utility of chimeric antigen receptor T-cell technology', Biochemical Society Transactions, vol. 46, no. 2, pp. 391-401. 24 23
2018	Gargett, T, Abbas, MN, Rolan, P, Price, JD, Gosling, KM, Ferrante, A, Ruszkiewicz, A, Atmosukarto, II, Altin, J, Parish, CR & Brown, MP 2018, 'Phase I trial of Lipovaxin-MM, a novel dendritic cell-targeted liposomal vaccine for malignant melanoma', Cancer Immunology Immunotherapy, vol. 67, no. 9, pp. 1461-1472. Open access 70 62
2016	Gargett, T, Christo, SN, Hercus, TR, Abbas, N, Singhal, N, Lopez, AF & Brown, MP 2016, 'GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro', Clinical and Translational Immunology, vol. 5, no. 12, article no. e119. Open access 36 29
2016	Gargett, T, Yu, W, Dotti, G, Yvon, ES, Christo, SN, Hayball, JD, Lewis, ID, Brenner, MK & Brown, MP 2016, 'GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 blockade', Molecular Therapy, vol. 24, no. 6, pp. 1135-1149. Open access 289 263 11
2015	Gargett, T & Brown, MP 2015, 'Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2', Cytotherapy, vol. 17, no. 4, pp. 487-495. 96 84
2015	Gargett, T, Fraser, CK, Dotti, G, Yvon, ES & Brown, MP 2015, 'BRAF and MEK inhibition variably affect GD2-specific chimeric antigen receptor (CAR) T-cell function in vitro', Journal of Immunotherapy, vol. 38, no. 1, pp. 12-23. 33 34
2014	Gargett, T & Brown, M 2014, 'The inducible caspase-9 suicide gene system as a 'safety switch' to limit on-target, off-tumor toxicities of chimeric antigen receptor T-cells', Frontiers in Pharmacology, vol. 5, article no. 235, pp. 1-7. Open access 277 249
2014	Gargett, T, Bruber-Bauk, B, Garrod, T, Yu, W, Miller, DS, Major, L, Wesselingh, S, Suhrbier, A & Gowans, E 2014, 'Induction of antigen-positive cell death by the expression of Perforin, but not DTa, from a DNA vaccine enhances the immune response', Immunology and Cell Biology, vol. 92, no. 4, pp. 359-367. 22 23
2014	Gargett, T, Grubor-Bauk, B, Miller, D, Garrod, T, Yu, S, Wesselingh, S, Suhrbier, A & Gowans, EJ 2014, 'Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein', Clinical and Translational Immunology, vol. 3, article no. e18, pp. 1-7. Open access 20
2014	Garrod, T, Grubor-Bauk, B, Yu, S, Gargett, T & Gowans, EJ 2014, 'Encoded novel forms of HSP70 or a cytolytic protein increase DNA vaccine potency', Human Vaccines and Immunotherapeutics, vol. 10, no. 9, pp. 2679-2683. Open access 9 10
2014	Garrod, TJ, Bruber-Bauk, B, Gargett, T, Li, Y, Miller, DS, Wenbo, Y, Major, L, Burrell, CJ, Wesselingh, S, Suhrbier, A & Gowans, EJ 2014, 'DNA vaccines encoding membrane-bound or secreted forms of heat shock protein 70 exhibit improved potency', European Journal of Immunology, vol. 44, no. 7, pp. 1992-2002. Open access 22 19
2014	Garrod, TJ, Gargett, T, Yu, W, Major, L, Burrell, CJ, Wesselingh, S, Suhrbier, A, Grubor-Bauk, B & Gowans, EJ 2014, 'Loss of long term protection with the inclusion of HIV pol to a DNA vaccine encoding gag', Virus Research, vol. 192, pp. 25-33. 6 6
2014	Yu, W, Grubor-Bauk, B, Gargett, T, Garrod, T & Gowans, EJ 2014, 'A novel challenge model to evaluate the efficacy of hepatitis C virus vaccines in mice', Vaccine, vol.32, no. 27, pp. 3409-3416. 14 13
2010	Brown, CY, Sadlon, T, Gargett, T, Melville, E, Zhang, R, Drabsch, Y, Ling, M, Strathdee, CA, Gonda, TJ & Barry, SC 2010, 'Robust, reversible gene knockdown using a single lentiviral short hairpin RNA vector', Human Gene Therapy, vol. 21, no. 8, pp. 1005-1017. Open access 27 28

Non Traditional Outputs

Year	Output
2021	Bailey, L, DeLosAngeles, D, Lawrance, D, Boddy, A, Gomez, G, Gargett, T, Tan, L & Coombs, J 2021, Cell invaders, It's Complicated, Australia, 2 February - 27 November 2021. Open access

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Amgen Inc	UNITED STATES
Australian National University	AUSTRALIA
Baylor College of Medicine	UNITED STATES
Combinatics	JAPAN
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Houston Methodist Hospital	UNITED STATES
Institute of Medical and Veterinary Science	AUSTRALIA
Lipotek Pty Ltd	AUSTRALIA
Peter MacCallum Cancer Centre	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queensland Institute of Medical Research	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Darwin Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Sydney Children's Hospital	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Texas	UNITED STATES
Women and Children's Health Research Institute	CANADA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Enhancing cancer immunotherapy success by efficient recruitment of T cells to solid tumours	Current
Identifying optimal immunotherapy combinations for the treatment of brain tumours	Current
Preclinical development of GD2 CAR-T cell therapy for glioblastoma	Current

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Dr Tessa Gargett

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Research

Research focus

Projects

Outputs

Journal Articles

Non Traditional Outputs

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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