Associate Professor Larisa Bobrovskaya

Associate Professor UniSA Clinical & Health Sciences

City East Campus (P5-16)
tel +61 8 830 21218

email Larisa.Bobrovskaya@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

Neurodegeneration
Depression
Diabetes
Stem Cell Research

Larisa is a leading neuroscientist and biochemist within UniSA Clinical and Health Sciences with expertise in stress response, diabetes and neurological disorders. Her research focuses on investigation of cellular and biochemical mechanisms of diseases, identifying novel biomarkers and testing novel treatments using animal models. She leads a number of research projects and supervises PhD and Honours students.

Larisa is also a passionate teacher. Her teaching philosophy is to provide students with the knowledge and skills that will allow them to successfully begin their professional career.

My Research Gate Profile

My Google Scholar Publications

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Highlights

Our research focuses on the following areas

1. Neurological disorders such as Alzheimer’s disease, Parkinson’s disease, depression and stroke

2. Role of Gut-Brain axis and nutrition in neurological disorders

3. Mechanisms of hypoglycaemia-associated autonomic failure in diabetes

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2018	Johnson, M, Salvatore, MF, Maiolo, S & Bobrovskaya, L 2018, 'Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson's progression: evidence from clinical studies and neurotoxin models', Progress in Neurobiology, vol. 165-167, pp. 1-25. Open access 40 38 1
2018	Johnson, ME, Stringer, A & Bobrovskaya, L 2018, 'Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease', NeuroToxicology, vol. 65, pp.174-185. Open access 78 67 10
2015	Johnson, ME & Bobrovskaya, L 2015, 'An update on the rotenone models of Parkinson's disease : their ability to reproduce the features of clinical disease and model gene-environment interactions', NeuroToxicology, vol. 46, pp. 101-116. 251 241 22

Chapters

Year	Output
2023	Kelliny, S, Deng, I, Zhou, XF & Bobrovskaya, L 2023, 'Sporadic Alzheimer's disease animal model using streptozotocin and APP/PS1 mice', in CR Martin, VB Patel & VR Preedy (eds), Handbook of Animal Models in Neurological Disorders, Academic Press, UK, ch. 2, pp. 17-30.

Journal Articles

Year	Output
2024	Braun, A, Manavis, J, Yamanaka, A, Ootsuka, Y, Blumbergs, P & Bobrovskaya, L 2024, 'The role of orexin in Parkinson's disease', Journal of Neuroscience Research, vol. 102, no. 3, article no. e25322, pp. 1-24. Open access 2
2024	Matricciani, L, Dumuid, D, Stanford, T, Maher, C, Bennett, P, Bobrovskaya, L, Murphy, A & Olds, T 2024, 'Time use and dimensions of healthy sleep: a cross-sectional study of Australian children and adults', Sleep Health, vol. 10, no. 3, pp. 348-355. Open access 1 1 228
2024	Senthilkumaran, M, Koch, C, Herselman, MF & Bobrovskaya, L 2024, 'Role of the adrenal medulla in hypoglycaemia-associated autonomic failure--a diabetic perspective', Metabolites, vol. 14, no. 2, article no. 100, pp. 1-27. Open access
2023	Cade, S, Zhou, X-F & Bobrovskaya, L 2023, 'An imbalance in the pro/mature BDNF ratio occurs in multiple brain regions during normal ageing in wild-type mice', Journal of Molecular Neuroscience, vol. 73, no. 6, pp. 469-484. Open access 3 3
2023	Herselman, MF & Bobrovskaya, L 2023, 'The effects of chronic unpredictable mild stress and semi-pure diets on the brain, gut and adrenal medulla in C57BL6 mice', International Journal of Molecular Sciences, vol. 24, no. 19, article no. 14618, pp. 1-38. Open access 2 2 1
2023	Herselman, MF, Lin, L, Luo, S, Yamanaka, A, Zhou, XF & Bobrovskaya, L 2023, 'Sex-dependent effects of chronic restraint stress on mood-related behaviours and neurochemistry in mice', International Journal of Molecular Sciences, vol. 24, no. 12, article no. 10353, pp. 1-19. Open access 4 4 1
2022	Bajic, JE, Howarth, GS, Mashtoub, S, Whittaker, AL, Bobrovskaya, L & Hutchinson, MR 2022, 'Neuroimmunological complications arising from chemotherapy-induced gut toxicity and opioid exposure in female dark agouti rats', Journal of Neuroscience Research, vol. 100, no. 1, pp. 237-250. 3 3 2
2022	Cade, S, Zhou, X-F & Bobrovskaya, L 2022, 'The role of brain-derived neurotrophic factor and the neurotrophin receptor p75NTR in age-related brain atrophy and the transition to Alzheimer's disease', Reviews in the Neurosciences, vol. 33, no. 5, pp. 515-529. Open access 6 5 1
2022	Daraghmeh, DN, Moghaddami, M, Bobrovskaya, L, Proudman, SM & Wiese, MD 2022, 'Quantitation of methotrexate polyglutamates in human whole blood, erythrocytes and leukocytes collected via venepuncture and volumetric absorptive micro-sampling: a green LC-MS/MS-based method', Analytical and Bioanalytical Chemistry, vol. 414, pp. 6029-6046. Open access 13 13 4
2022	Deng, I & Bobrovskaya, L 2022, 'Lipopolysaccharide mouse models for Parkinson's disease research: a critical appraisal', Neural Regeneration Research, vol. 17, no. 11, pp. 2413-2417. Open access 6 6 1
2022	Deng, I, Garg, S, Zhou, X-F & a Bobrovskaya, L 2022, 'The effects of novel formulations of edaravone and curcumin in the mouse intrastriatal lipopolysaccharide model of Parkinson's disease', Frontiers in Bioscience (Scholar Edition), vol. 14, no. 2, pp.1-17. Open access 2 3
2022	Herselman, MF, Bailey, S & Bobrovskaya, L 2022, 'The effects of stress and diet on the 'brain-gut' and 'gut-brain' pathways in animal models of stress and depression', International Journal of Molecular Sciences, vol. 23, no. 4, article no. 2013, pp. 1-31. Open access 24 23 1
2022	Herselman, MF, Bailey, S, Deo, P, Zhou, X-F, Gunn, KM & Bobrovskaya, L 2022, 'The effects of walnuts and academic stress on mental health, general well-being and the gut microbiota in a sample of university students: a randomised clinical trial', Nutrients, vol. 14, no. 22, article no, 4776, pp. 1-35. Open access 9 6 676
2022	Lin, L, Herselman, MF, Zhou, X-F & Bobrovskaya, L 2022, 'Effects of corticosterone on BDNF expression and mood behaviours in mice', Physiology and Behavior, vol. 247, article no. 113721. Open access 24 24
2022	Liu, D, Rychkov, G, Hurtado, P, Luo, HY, Zhang, T, Bobrovskaya, L & Zhou, XF 2022, 'Conversion of human fibroblasts into induced neural stem cells by small molecules', International Journal of Molecular Sciences, vol. 23, no. 3, article no. 1740. Open access 4 3 1
2022	Xiong, J, Deng, I, Kelliny, S, Lin, L, Bobrovskaya, L & Zhou, X-F 2022, 'Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice', Metabolic Brain Disease, vol. 37, no. 6, pp. 1941-1957. Open access 12 12 562
2021	Deng, I, Corrigan, F, Garg, S, Zhou, XF & Bobrovskaya, L 2021, 'Further characterization of intrastriatal lipopolysaccharide model of parkinson's disease in c57bl/6 mice', International Journal of Molecular Sciences, vol. 22, no. 14, pp. 1-20. Open access 10 9 11
2021	Deng, I, Wiese, MD, Zhou, XF & Bobrovskaya, L 2021, 'The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice', NeuroToxicology, vol. 85, pp. 254-264. Open access 9 9 1
2021	Kelliny, S, Bobrovskaya, L, Zhou, X-F & Upton, R 2021, 'Pharmacokinetic modelling of human recombinant protein, p75ECD-Fc: a novel therapeutic approach for treatment of Alzheimer's disease, in serum and tissue of Sprague Dawley rats', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 2, pp. 235-248. Open access 2 2
2021	Kelliny, S, Lin, L, Deng, I, Xiong, J, Zhou, F, Al-Hawwas, M, Bobrovskaya, L & Zhou, XF 2021, 'A new approach to model sporadic Alzheimer's disease by intracerebroventricular streptozotocin injection in APP/PS1 mice', Molecular Neurobiology, vol. 58, no. 8, pp. 3692-3711. Open access 11 9 7
2021	Kelliny, S, Xiong, J, Bobrovskaya, L & Zhou, XF 2021, 'Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia', Neurotoxicity Research, vol. 39, no. 6, pp. 1689-1707. 3 3 7
2021	Lin, L, Fu, Xy, Zhou, X, Liu, D, Bobrovskaya, L & Zhou, L 2021, 'Analysis of blood mature BDNF and proBDNF in mood disorders with specific ELISA assays', Journal of Psychiatric Research, vol. 133, pp. 166-173. 22 20 157
2021	Lin, L, Zhou, X-F & Bobrovskaya, L 2021, 'Blockage of p75NTR ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress', Behavioural Brain Research, vol. 396, article no. 112905, pp. 1-5. Open access 8 7
2021	Liu, D, Bobrovskaya, L & Zhou, XF 2021, 'Cell therapy for neurological disorders: the perspective of promising cells', Biology, vol. 10, no. 11, article no. 1142, pp. 1-23. Open access 11 8
2021	Xiong, LL, Tan, YX, Du, RL, Peng, Y, Xue, LL, Liu, J, Al-Hawwas, M, Bobrovskaya, L, Liu, DH, Chen, L, Wang, TH & Zhou, XF 2021, 'Effect of sutellarin on neurogenesis in neonatal hypoxia-ischemia rat model: potential mechanisms of action', American Journal of Chinese Medicine, vol. 49, no. 3, pp. 677-703. 10 7
2021	Zidan, AA, Al-Hawwas, M, Perkins, GB, Mourad, GM, Stapledon, CJ, Bobrovskaya, L, Zhou, X-F & Hurtado, PR 2021, 'Characterization of urine stem cell-derived extracellular vesicles reveals B cell stimulating cargo', International Journal of Molecular Sciences, vol. 22, no. 1, pp. 1-21. Open access 18 17
2021	Zidan, AA, Perkins, G, Al-Hawwas, M, Elhossiny, A, Yang, J, Bobrovskaya, L, Mourad, GM, Zhou, XF & Hurtado, PR 2021, 'Urine stem cells are equipped to provide B cell survival signals', Stem Cells, vol. 39, no. 6, pp. 803-818. Open access 5 5 5
2020	Deng, I, Corrigan, F, Zhai, G, Zhou, X-F & Bobrovskaya, L 2020, 'Lipopolysaccharide animal models of Parkinson's disease: recent progress and relevance to clinical disease', Brain, Behavior, & Immunity - Health, vol. 4, article no. 100060, pp. 1-12. Open access 68 10
2020	Kelliny, S, Lam, H, Parikh, A, Wang, Y, Bobrovskaya, L, Upton, R & Zhou, X 2020, 'Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer's disease, in sprague dawley rats', Current Drug Metabolism, vol. 21, no. 3, pp. 235-244. 7 6
2020	Li, H, Lin, LY, Zhang, Y, Lim, Y, Rahman, M, Beck, A, Al-Hawwas, M, Feng, S, Bobrovskaya, L & Zhou, XF 2020, 'Pro-BDNF knockout causes abnormal motor behaviours and early death in mice', Neuroscience, vol. 438, pp. 145-157. 9 8 1
2020	Lin, L, Kelliny, S, Liu, L, Al-Hawwas, M, Zhou, X & Bobrovskaya, L 2020, 'Peripheral ProBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice', Neurotoxicity Research, vol. 38, no. 3, pp. 626-639. 6 6 1
2020	Liu, D, Pavathuparambil Abdul Manaph, N, Al-Hawwas, M, Bobrovskaya, L, Xiong, LL & Zhou, XF 2020, 'Coating materials for neural stem/progenitor cell culture and differentiation', Stem Cells and Development, vol. 29, no, 8, pp. 463-474. 19 17
2020	Liu, D, Rychkov, G, Al-Hawwas, M, Pavathuparambil Abdul Manaph, N, Zhou, F, Bobrovskaya, L, Liao, H & Zhou, XF 2020, 'Conversion of human urine-derived cells into neuron-like cells by small molecules', Molecular Biology Reports: An International Journal on Molecular and Cellular Biology, vol. 47, no. 4, pp. 2713-2722. 14 15 6
2020	Rahman, M, Luo, H, Bobrovskaya, L & Zhou, X-F 2020, 'Neuroprotective effects of anti-proBDNF in a rat photothrombotic ischemic model', Neuroscience, vol. 446, pp. 261-270. 2
2020	Xiong, L-L, Xue, L-L, Du, R-L, Zhou, H-L, Tan, Y-X, Ma, Z, Jin, Y, Zhang, Z-B, Xu, Y, Hu, Q, Bobrovskaya, L, Zhou, X-F, Liu, J & Wang, T-H 2020, 'Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis', Frontiers in Cell and Developmental Biology, vol. 8, article no. 529544, pp. 1-18. Open access 27 23 1
2019	Johnson, ME, Zhou, X-F & Bobrovskaya, L 2019, 'The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 97, pp. 23-32. Open access 10 10
2019	Lin, L, Luo, S, Al-Hawwas, M, Herselman, M, Zhou, X & Bobrovskaya, L 2019, 'The long-term effects of ethanol and corticosterone on the mood-related behaviours and the balance between mature BDNF and proBDNF in mice', Journal of Molecular Neuroscience, vol. 69, no. 1, pp. 60-68. Open access 17 15 6
2019	Luo, HY, Rahman, M, Bobrovskaya, L & Zhou, X-F 2019, 'The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke', Neurotoxicity Research, vol. 36, no. 1, pp. 49-57. 8 8
2019	Manucat-Tan, NB, Shen, LL, Bobrovskaya, L, Al-hawwas, M, Zhou, FH, Wang, YJ & Zhou, XF 2019, 'Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model', Aging, vol. 11, no. 17. pp. 6762-6791. Open access 18 15 7
2019	Shehadeh, J, Double, KL, Murphy, KE, Bobrovskaya, L, Reyes, S, Dunkley, PR, Halliday, GM & Dickson, PW 2019, 'Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease', Neurobiology of Disease, vol. 130, article no. 104524, pp. 1-8. Open access 20 15 11
2019	Zhang, Y, Rauf Khan, A, Fu, M, Zhai, Y, Ji, J, Bobrovskaya, L & Zhai, G 2019, 'Advances in curcumin-loaded nanopreparations: improving bioavailability and overcoming inherent drawbacks', Journal of Drug Targeting, vol. 27, no. 9, pp. 917-931. 43 37
2019	Zhang, Z-B, Tan, Y-X, Zhao, Q, Xiong, L-L, Liu, J, Xu, F-F, Xu, Y, Bobrovskaya, L, Zhou, X-F & Wang, T-H 2019, 'miRNA-7a-2-3p inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model', Frontiers in Neuroscience, vol. 13, article 16, pp. 1-10. Open access 32 28 1
2018	Johnson, M, Salvatore, MF, Maiolo, S & Bobrovskaya, L 2018, 'Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson's progression: evidence from clinical studies and neurotoxin models', Progress in Neurobiology, vol. 165-167, pp. 1-25. Open access 40 38 1
2018	Johnson, ME, Stringer, A & Bobrovskaya, L 2018, 'Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease', NeuroToxicology, vol. 65, pp.174-185. Open access 78 67 10
2018	Lim, Y, Wu, LLY, Chen, S, Sun, Y, Vijayaraj, SL, Yang, M, Bobrovskaya, L, Keating, D, Li, XJ & Zhou, X-F 2018, 'HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons', Molecular Neurobiology, vol. 55, no. 3, pp. 1815-1830. Open access 21 18
2018	Maiolo, SA, Fan, P & Bobrovskaya, L 2018, 'Bioactive constituents from cinnamon, hemp seed and polygonum cuspidatum protect against H₂O₂ but not rotenone toxicity in a cellular model of Parkinson's disease', Journal of Traditional and Complementary Medicine, vol. 8, no. 3, pp. 420-427. Open access 24
2018	Mañucat-Tan, NB, Saadipour, K, Wang, Y-J, Bobrovskaya, L & Zhou, X-F 2018, 'Cellular trafficking of amyloid precursor protein in amyloidogenesis physiological and pathological significance', Molecular Neurobiology, vol. 56, no. 2, pp. 812-830. Open access 21 21
2018	Pavathuparambil Abdul Manaph, N, Al-Hawaas, M, Bobrovskaya, L, Coates, PT & Zhou, XF 2018, 'Urine-derived cells for human cell therapy', Stem Cell Research and Therapy, vol. 9, no. 1, article no. 189, pp. 1-12. Open access 61 57 6
2018	Rahman, M, Luo, H, Sims, NR, Bobrovskaya, L & Zhou, XF 2018, 'Investigation of mature BDNF and proBDNF signaling in a rat photothrombotic ischemic model', Neurochemical Research, vol. 43, no. 3, pp. 637-649. Open access 27 24
2018	Ruan, C-S, Liu, J, Yang, M, Saadipour, K, Zeng, YQ, Liao, H, Wang, YJ, Bobrovskaya, L & Zhou, X-F 2018, 'Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP', Experimental Neurology, vol. 299, Part A, pp. 75-85. 12 12 7
2018	Ruan, C-S, Zeng, Y-Q, Guo, Y, Bobrovskaya, L & Zhou, X-F 2018, 'A pilot study in modeling mood disorders in mice by chronic tail-suspension stress', Neuropsychiatry, vol. 8, no. 5, pp. 1586-1592. Open access
2018	Saadipour, K, Mañucat-Tan, NB, Lim, Y, Keating, DJ, Smith, KS, Zhong, JH, Liao, H, Bobrovskaya, L, Wang, YJ, Chao, M V & Zhou, XF 2018, 'p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis', Journal of Neurochemistry, vol. 144, no. 3, pp. 302-317. Open access 26 25 1
2018	Senthilkumaran, M & Bobrovskaya, L 2018, 'The effects of recurrent hypoglycaemia and opioid antagonists on the adrenal catecholamine synthetic capacity in a rat model of HAAF', Autonomic Neuroscience: Basic and Clinical, vol. 210, pp. 76-80. 10 9
2018	Senthilkumaran, M, Bobrovskaya, L, Verberne, A & Llewellyn-Smith, I 2018, 'Insulin‐responsive autonomic neurons in rat medulla oblongata', Journal of Comparative Neurology, vol. 526, no. 16, pp. 2665-2682. 7 7 1
2018	Shen, L-L, Manucat-Tan, NB, Gao, S-H, Li, W-W, Zeng, F, Zhu, C, Wang, J, Bu, X-L, Liu, Y-H, Gao, C-Y, Xu, Z-Q, Bobrovskaya, L, Lei, P, Yu, J-T, Song, W, Zhou, H-D, Yao, X-Q, Zhou, X-F & Wang, Y-J 2018, 'The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau', Molecular Psychiatry, vol. 23, no. 8, pp. 1813-1824. 39 35 54
2018	Xiong, L-L, Xiao, Q-X, AI-Hawwas, M, Bobrovskaya, L, Liu, DH & Zhou, X-F 2018, 'Treatment of hypoxic-ischemic encephalopathy in neonates: a systematic review and meta-analysis', vol. 4, no. 4, pp. 52-61. Open access 1
2017	Barker, T, Bobrovskaya, L, Howarth, G & Whittaker, A 2017, 'Female rats display fewer optimistic responses in a judgment bias test in the absence of a physiological stress response', Physiology and Behavior, vol. 173, pp. 124-131. Open access 16 14 1
2017	Li, J-Y, Liu, J, Pavathuparambil Abdul Manaph, N, Bobrovskaya, L & Zhou, X-F 2017, 'ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells', Brain Research, vol. 1668, pp. 46-55. 42 39 10
2017	Luo, Q, Yan, X, Bobrovskaya, L, Ji, M, Yuan, H, Lou, H & Fan, P 2017, 'Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells', Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease, vol. 428, no. 1, pp. 129-137. 71 62 3
2017	Ruan, C-S, Bobrovskaya, L & Zhou, X-F 2017, 'Female wild-type and APP/PS1 transgenic mice deficient in Sort1 are prone to anxiety-like behavior at older ages', Neuropsychiatry, vol. 7, no. 6, pp. 1047-1052. Open access
2016	Bai, Y-Y, Ruan, C-S, Yang, C-R, Li, J-Y, Kang, Z-L, Zhou, L, Liu, D, Zeng, Y-Q, Wang, T-H, Tian, C-F, Liao, H, Bobrovskaya, L & Zhou, X-F 2016, 'ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress', Neuropsychopharmacology, vol. 41, no. 12, pp. 2882-2892. Open access 92 87 2
2016	Ruan, C-S, Yang, C-R, Li, J-Y, Luo, H-Y, Bobrovskaya, L & Zhou, X-F 2016, 'Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior', Experimental Neurology, vol. 281 pp. 99-108. 23 22
2016	Senthilkumaran, M, Johnson, ME & Bobrovskaya, L 2016, 'The effects of insulin-induced hypoglycaemia on tyrosine hydroxylase phosphorylation in rat brain and adrenal gland', Neurochemical Research, vol. 41, no. 7, pp. 1612-1624. 18 17 3
2016	Senthilkumaran, M, Zhou, X-F & Bobrovskaya, L 2016, 'Challenges in modelling hypoglycaemia-associated autonomic failure: A review of human and animal studies', International Journal of Endocrinology, vol. 2016, article no. 9801640, pp. 1-13. Open access 16 16
2015	Johnson, ME & Bobrovskaya, L 2015, 'An update on the rotenone models of Parkinson's disease : their ability to reproduce the features of clinical disease and model gene-environment interactions', NeuroToxicology, vol. 46, pp. 101-116. 251 241 22
2015	Johnson, ME, Lim, Y, Senthilkumaran, M, Zhou, X-F & Bobrovskaya, L 2015, 'Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 70, pp. 33-41. 31 26
2015	Wang, KC, Brooks, DA, Summers-Pearce, B, Bobrovskaya, L, Tosh, DN, Duffield, JA, Botting, KJ, Zhang, S, McMillen, C & Morrison, JL 2015, 'Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life', Physiological Reports, vol. 3, no. 2, article no. e12270, pp. 1-16. Open access 22 16 1
2014	Johnson, J, Rolan, P, Johnson, ME, Bobrovskaya, L, Williams, D, Johnson, K, Tuke, J & Hutchinson, M 2014, 'Codeine-induced hyperalgesia and allodynia : investigating the role of glial activation', Translational Psychiatry, vol. 4, article no. e482, pp. 1-9. Open access 31 31 4
2014	Ong, LK, Guan, L, Damanhuri, H, Goodchild, AK, Bobrovskaya, L, Dickson, PW & Dunkley, PR 2014, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', Journal of Neurochemistry, vol. 128, no. 4, pp. 547-560. Open access 33 33
2013	Bobrovskaya, L, Beard, D, Bondarenko, E, Beig, M I, Jobling, P, Walker, FR, Day, TA & Nalivaiko, E 2013, 'Does exposure to chronic stress influence blood pressure in rats?', Autonomic Neuroscience: Basic and Clinical, vol. 177, no. 2, pp. 217-223. 19 15
2013	Bobrovskaya, L, Maniam, J, Ong, LK, Dunkley, PR & Morris, MJ 2013, 'Early life stress and post-weaning high fat diet alter tyrosine hydroxylase regulation and AT1 receptor expression in the adrenal gland in a sex dependent manner', Neurochemical Research, vol. 38, no. 4, pp. 826-833. 12 11
2012	Damanhuri, HA, Burke, PG, Ong, LK, Bobrovskaya, L, Dickson, PW, Dunkley, PR & Goodchild, AK 2012, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions : a marker of activation following acute hypotension and glucoprivation', PLoS One, vol. 7, no. 11, article no. e50535. Open access 31 31
2012	Sominsky, L, Meehan, CL, Walker, AK, Bobrovskaya, L, McLaughlin, EA & Hodgson, DM 2012, 'Neonatal immune challenge alters reproductive development in the female rat', Hormones and Behaviour, vol. 62, no. 3, pp. 345-355. 51 46
2011	Aumann, TD, Egan, K, Lim, J, Boon, WC, Bye, CR, Chua, HK, Baban, N, Parish, CL, Bobrovskaya, L, Dickson, P & Horne, MK 2011, 'Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons', Journal of Neurochemistry, vol. 116, no. 4, pp. 646-658. Open access 45 43
2011	Ong, L, Bobrovskaya, L, Walker, F, Day, T, Dickson, P & Dunkley, P 2011, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, vol. 36, no. 1, pp. 27-33. 15 14
2011	Ong, L, Guan, L, Stutz, B, Dickson, P, Dunkley, P & Bobrovskaya, L 2011, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, vol. 192, pp. 20-27. Open access 22 20
2010	Bobrovskaya, L, Damanhuri, HA, Ong, LK, Schneider, JJ, Dickson, PW, Dickson, PR & Goodchild, AK 2010, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: an in vivo analysis', Neurochemistry International, vol. 57, no. 2, pp. 162-167. 23 21
2010	Franco, J, Posser, T, Gordon, S, Bobrovskaya, L, Schneider, J, Farina, M, Dafre, A, Dickson, P & Dunkley, P 2010, 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, vol. 113, no. 1, pp. 150-157. Open access 19 18
2009	Gordon, SL, Bobrovskaya, L, Dunkley, PR & Dickson, PW 2009, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ : isoform 2 is not phosphorylated at Ser35', BBA: Molecular Cell Research, vol. 1793, no. 12, pp. 1860-1867. Open access 44 41
2009	Posser, T, Franco, JL, Bobrovskaya, L, Leal, RB, Dickson, PW & Dunkley, PR 2009, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, vol. 110, no. 3, pp. 848-856. 37 35

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Alexandria University	EGYPT
China Pharmaceutical University	CHINA
Chinese Institute for Brain Research	CHINA
Daping Hospital	CHINA
Federal University of Pampa (Brazil)	BRAZIL
Flinders University	AUSTRALIA
Griffith University	AUSTRALIA
Hamad bin Khalifa University	QATAR
Kunming Medical University	CHINA
Macquarie University	AUSTRALIA
Medicinova	UNITED STATES
Neuroscience Research Australia	AUSTRALIA
New York University	UNITED STATES
Qingdao University	CHINA
Royal Adelaide Hospital	AUSTRALIA
Shandong University	CHINA
Shijiazhuang Maternity and Child Healthcare Hospital	CHINA
Sichuan University	CHINA
Southwest Medical University	CHINA
Sun Yat-Sen University	CHINA
Third Military Medical University	CHINA
Tianjin Medical University	CHINA
Universidade Federal de Santa Catarina	BRAZIL
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Illinois at Urbana-Champaign	UNITED STATES
University of Melbourne	AUSTRALIA
University of Michigan	UNITED STATES
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of North Texas	UNITED STATES
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University School of Medicine	UNITED STATES
West China Hospital	CHINA
Xiangya Hospital	CHINA
Yunnan Mental Hospital	CHINA

External engagement & recognition

Engagement/recognition	Year
Member Australian Physiological Society	2018
Member Australian Neuroscience Society	2018
Member Australasian Society of Clinical Biochemists	2018
Member Australian Neuroscience Society	2017
Member Australian Physiological Society	2017
Member Australasian Society of Clinical Biochemists	2017

Other

Member of Sansom Institute

Teaching & student supervision

Highlights

Biochemistry, Clinical Chemistry, Molecular Pathology

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Bridging the Sex and Gender Gap in Parkinson's disease Research	Current
Decorated cubosomes for anti-cancer drugs delivery and targeting	Current
Discovering the Roles of Orexins in Parkinson's disease	Current
Psychotropic pharmacotherapy and its chronic health implications for people in custody in South Australian prisons	Current
Role of Gut Bacteria in Dementia and Implications for Future Nanomedicine	Current
A role for p75 neurotrophin receptor in Neurodegeneration in Alzheimer's disease and tauopathy	Completed
Age and comorbidity: their influence on colorectal cancer stage, treatment and survival in South Australia	Completed
Characterisation of lipopolysaccharide models of Parkinson¿s disease, and the effects of edaravone and curcumin	Completed
Characterization of proBDNF knock out mice and effect of proBDNF on angiogenesis	Completed
Chronic stress, nutrition and gut health: possible links and implications for chronic stress-induced depression	Completed
Conversion of human urine cells and fibroblasts into neural cells with small molecules	Completed
Development of thermoresponsive polysaccharides as tunable delivery systems	Completed
Functions of proBDNF and its signaling receptor p75 in neuroprotection after ischemic stroke	Completed
Further characterisation of the rotenone model: investigation of TH and BDNF in the brain and periphery, and associated gastrointestinal dysfunction	Completed
Hypoglycaemia-associated autonomic failure: the involvement of catecholamine producing cells in the brain and adrenal gland	Completed
Investigation into a small molecule aided conversion of human urine cells into hepatocyte-like cells and beta-like cells in vitro	Completed
Investigation into signalling mechanisms of BDNF in neurological disorders	Completed
Investigation of BDNF and its precursor protein proBDNF in depression	Completed
Investigation of therapeutic intervention for neonatal hypoxic-ischemic brain injury	Completed
Roles of precursor of brain-derived neurotrophic factor in neuronal development and neurodegeneration	Completed
The role of brain derived neurotrophic factor and the neurotrophin receptor p75NTR in the pathogenesis of Alzheimer¿s disease	Completed
The role of sortilin in regulating the pathological hallmarks and behavioural symptoms in Alzheimer¿s disease	Completed
Validation of p75ECD and edaravone as neuroprotective drug candidates for neurodegenerative diseases	Completed

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Associate Professor Larisa Bobrovskaya

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UniSA Clinical & Health Sciences

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