Dr Alex Staudacher

Adjunct Senior Research Fellow Centre for Cancer Biology

City West Campus (HB9-28)
tel +61 8 830 27823

email Alex.Staudacher@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Clinical Sciences
Oncology and Carcinogenesis
Biomedical Engineering
Pharmacology and Pharmaceutical Sciences
Other Physical Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included.

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Wittwer, NL, Brown, MP, Liapis, V & Staudacher, AH 2023, 'Antibody drug conjugates: hitting the mark in pancreatic cancer?', Journal of Experimental and Clinical Cancer Research, vol. 42, no. 1, article no. 280, pp. 1-16. Open access 20 17
2023	Wittwer, NL, Staudacher, AH, Liapis, V, Cardarelli, P, Warren, H & Brown, MP 2023, 'An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer', Journal for ImmunoTherapy of Cancer, vol. 11, no. 3, pp. 1-16. Open access 17 18
2022	Hull, A, Li, Y, Bartholomeusz, D, Hsieh, W, Tieu, W, Pukala, TL, Staudacher, AH & Bezak, E 2022, 'Preliminary development and testing of C595 radioimmunoconjugates for targeting MUC1 cancer epitopes in pancreatic ductal adenocarcinoma', Cells, vol. 11, no. 19, pp. 1-18. Open access 3 3
2022	Nazarizadeh, A, Staudacher, AH, Wittwer, NL, Turnbull, T, Brown, MP & Kempson, I 2022, 'Aluminium nanoparticles as efficient adjuvants compared to their microparticle counterparts: current progress and perspectives', International Journal of Molecular Sciences, vol. 23, no. 9, article no. 4707. Open access 31 28 4
2022	Staudacher, AH, Li, Y, Liapis, V & Brown, MP 2022, 'The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines', Cancer Reports, vol. 5, no. 8, article no. e1543, pp. 1-11. Open access 6 6
2022	Staudacher, AH, Liapis, V, Wittwer, NL, Tieu, W, Lam, HC, Leusen, J & Brown, MP 2022, 'Fc gamma receptor is not required for in vivo processing of radio- and drug-conjugates of the dead tumor cell-targeting monoclonal antibody, APOMAB®', Biomedicine and Pharmacotherapy, vol. 151, article no. 113090, pp. 1-10. Open access 1
2021	Liapis, V, Tieu, W, Wittwer, NL, Gargett, T, Evdokiou, A, Takhar, P, Rudd, SE, Donnelly, PS, Brown, MP & Staudacher, AH 2021, 'Positron emission tomographic imaging of tumor cell death using zirconium-89-labeled APOMAB® following cisplatin chemotherapy in lung and ovarian cancer xenograft models', Molecular Imaging and Biology, vol. 23, no. 6, pp. 914-928. Open access 8 8
2021	MacGregor, M, Safizadeh Shirazi, H, Chan, KM, Ostrikov, K, McNicholas, K, Jay, A, Chong, M, Staudacher, AH, Michl, TD, Zhalgasbaikyzy, A, Brown, MP, Kashani, MN, Di Fiore, A, Grochowski, A, Robb, S, Belcher, S, Li, J, Gleadle, JM & Vasilev, K 2021, 'Cancer cell detection device for the diagnosis of bladder cancer from urine', Biosensors and Bioelectronics, vol. 171, article no. 112699, pp. 1-12. Open access 35 29
2020	Reid, P, Staudacher, AH, Marcu, LG, Olver, I, Moghaddasi, L & Brown, MP 2020, 'Influence of the human papillomavirus on the radio-responsiveness of cancer stem cells in head and neck cancers', Scientific Reports, vol. 10, no. 1, article no. 2716, pp. 1-8. Open access 12 13
2020	Reid, P, Staudacher, AH, Marcu, LG, Olver, I, Moghaddasi, L, Brown, MP, Li, Y & Bezak, E 2020, 'Intrinsic radiosensitivity is not the determining factor in treatment response differences between HPV negative and HPV positive head and neck cancers', Cells, vol. 9, no. 8, pp. 1-14. Open access 7 7 6
2020	Staudacher, AH, Liapis, V, Tieu, W, Wittwer, NL & Brown, MP 2020, 'Tumour-associated macrophages process drug and radio-conjugates of the dead tumour cell-targeting APOMAB® antibody', Journal of Controlled Release, vol. 327, pp. 779-787. 9 10
2019	Reid, P, Marcu, LG, Olver, I, Moghaddasi, L, Staudacher, AH & Bezak, E 2019, 'Diversity of cancer stem cells in head and neck carcinomas: the role of HPV in cancer stem cell heterogeneity, plasticity and treatment response', Radiotherapy and Oncology, vol. 135, pp. 1-12. 29 28 1
2019	Staudacher, AH, Li, Y, Liapis, V, Hou, JJC, Chin, D, Dolezal, O, Adams, TE, van Berkel, PH & Brown, MP 2019, 'APOMAB antibody-drug conjugates targeting dead tumor cells are effective in vivo', Molecular Cancer Therapeutics, vol. 18, no. 2, pp. 335-345. Open access 18 18
2018	Reid, P, Wilson, P, Li, Y, Marcu, LG, Staudacher, AH, Brown, MP & Bezak, E 2018, 'Experimental investigation of radiobiology in head and neck cancer cell lines as a function of HPV status, by MTT assay', Scientific Reports, vol. 8, article no. 7744, pp. 1-7. Open access 9 9 10
2017	Reid, P, Wilson, P, Li, Y, Marcu, LG, Staudacher, AH, Brown, MP & Bezak, E 2017, 'In vitro investigation of head and neck cancer stem cell proportions and their changes following x-ray irradiation as a function of HPV status', PLoS One, vol. 12, no. 10, article no. e0186186, pp. 1-16. Open access 20 18 2
2017	Staudacher, AH & Brown, MP 2017, 'Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?', British Journal of Cancer, vol. 117, no. 12, pp. 1736-1742. Open access 376 341
2016	Ormsby, RJ, Staudacher, AH, Blyth, BJ, Bezak, E & Sykes, PJ 2016, 'Temporal responses to X-radiation exposure in spleen in the pKZ1 mouse recombination assay', Radiation Research, vol. 185, no. 6, pp. 623-629. 4 4
2015	Darwish, RA, Staudacher, AH, Bezak, E & Brown, MP 2015, 'Autoradiography imaging in targeted alpha therapy with Timepix detector', Computational and Mathematical Methods in Medicine, vol. 2015, article no. 612580, pp. 1-7. Open access 14 7
2014	Penfold, SN, Brown, MP, Staudacher, AH & Bezak, E 2014, 'Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy', Applied Radiation and Isotopes, vol. 90, pp. 40-45. 9 7
2014	Staudacher, AH, Al-Ejeh, F, Fraser, CK, Darby, JM, Roder, DM, Ruszkiewicz, A, Manavis, J & Brown, MP 2014, 'The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®', EJNMMI Research, vol. 4, article no. 2, pp. 1-13. Open access 23 20
2014	Staudacher, AH, Bezak, E, Borysenko, A & Brown, MP 2014, 'Targeted α-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation', Nuclear Medicine Communications, vol. 35, no. 12, pp. 1284-1290. 3 20
2010	Staudacher, AH, Blyth, BJ, Lawrence, MD, Ormsby, RJ, Bezak, E & Sykes, P 2010, 'If bystander effects for apoptosis occur in spleen after low-dose irradiation in vivo then the magnitude of the effect falls within the range of normal homeostatic apoptosis', Radiation Research, vol. 174, no. 6a, pp. 0033-7587. 13 12

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
GPCR Therapeutics	KOREA, REPUBLIC OF (SOUTH)
Hanson Institute	AUSTRALIA
Motherson Innovations Australia	AUSTRALIA
Queensland Institute of Medical Research	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
Utrecht University Medical Center	NETHERLANDS

External engagement & recognition

Engagement/recognition	Year
Member SA Pathology Radiation Safety Committee	2016
Member Australian Society of Immunology	2016
Member European Association of Nuclear Medicine	2016
Project Grant National Health and Medical Research Council (NHMRC)	2016
Reviewer Journal of Radioanalytical and Nuclear Chemistry	2016
Reviewer International Journal of Molecular Sciences	2016
Member Australian Society of Immunology	2015
Member European Association of Nuclear Medicine	2015
Member SA Pathology Radiation Safety Committee	2015
Reviewer Biomedical Research and Therapy	2015
Reviewer Journal of Radioanalytical and Nuclear Chemistry	2015
Reviewer AIMS Medical Science	2015
Reviewer International Journal of Molecular Sciences	2015
Member European Association of Nuclear Medicine	2014
Member Australian Society of Immunology	2014
Member SA Pathology Radiation Safety Committee	2014
Reviewer International Journal of Molecular Sciences	2014
Reviewer Journal of Radioanalytical and Nuclear Chemistry	2014
Eckert and Ziegler EANM Abstract Award Eckert and Ziegler	2013
Member European Association of Nuclear Medicine	2013
Member SA Pathology Radiation Safety Committee	2013
Member Australian Society of Immunology	2013
Reviewer Journal of Radioanalytical and Nuclear Chemistry	2013
Member Australian Society of Immunology	2012

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Comparative radiobiology of HPV positive and HPV negative head and neck cancers	Completed
Investigation of radiosensitization mechanisms using gold and aluminium nanoparticles under clinical beam radiation in the 4T1 mouse model of breast cancer	Completed

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Dr Alex Staudacher

About me

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Centre for Cancer Biology

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Journal Articles

External engagement & recognition

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