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Dr Alexander Lewis

Visiting Academic Centre for Cancer Biology

tel +61 8 830 20639

email Alexander.Lewis@unisa.edu.au

Research

Research focus

Biochemistry and Cell Biology
Biological Sciences
Cardiovascular Medicine and Haematology
Medical and Health Sciences
Chemical Sciences

Research

Outputs

Research outputs for the last seven years are shown below.

Open access indicates that an output is open access.

Journal Articles

Year	Output
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 8 6 78
2022	Pitman, MR, Lewis, AC, Davies, LT, Moretti, PA, Anderson, D, Creek, DJ, Powell, JA & Pitson, SM 2022, 'The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism', Scientific Reports, vol. 12, no. 1, article no.454, pp. 1-12. Open access 3 2 90
2020	Boyle, ST, Poltavets, V, Kular, J, Pyne, NT, Sandow, JJ, Lewis, AC, Murphy, KJ, Kolesnikoff, N, Moretti, PAB, Tea, MN, Tergaonkar, V, Timpson, P, Pitson, SM, Webb, AI, Whitfield, RJ, Lopez, AF, Kochetkova, M & Samuel, MS 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, pp. 1-32. 38 36
2019	Powell, JA, Pitman, MR, Zebol, JR, Moretti, PA, Neubauer, HA, Davies, LT, Lewis, AC, Dagley, LF, Webb, A I, Costabile, M & Pitson, SM 2019, 'Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1', Biochemical Journal, vol. 476, no. 21, pp. 3211-3226. Open access 9 9
2019	Wallington-Beddoe, CT, Xie, V, Tong, D, Powell, JA, Lewis, AC, Davies, L, Pitson, SM, Bradstock, KF & Bendall, LJ 2019, 'Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia', British Journal of Haematology, vol. 184, no. 3, pp. 443-447. Open access 7 8 1
2018	Lewis, AC, Wallington-Beddoe, CT, Powell, JA & Pitson, SM 2018, 'Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies', Cell Death Discovery, vol. 4, no. 1, article no. 72, pp. 1-11. Open access 42 48 1
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 57 55 85

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Monash University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Stanford University	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Westmead Hospital	AUSTRALIA

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