Dr Alexandra Sorvina

Centre for Cancer Biology Centre for Cancer Biology

City West Campus (HB11-27)
tel +61 8 830 21731

email Alexandra.Sorvina@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Biochemistry and Cell Biology
Other Chemical Sciences
Chemical Sciences
Inorganic Chemistry
Medicinal and Biomolecular Chemistry

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2012	Shandala, T, R Kakavanos-Plew, Ng, Y, Bader, CA, Sorvina, A, Parkinson-Lawrence, E, Brooks, RD, Borlace, G, Prodoehl, M & Brooks, D 2012, 'Molecular machinery regulating exocytosis', in R Weigert (ed.), Crosstalk and integration of membrane trafficking pathways, InTech, Croatia, ch. 4, pp. 61-108. Open access

Journal Articles

Year	Output
2025	Lam, G, Martini, C, Sorvina, A, Hickey, S, Hindes, M, Waugh, D, O'Leary, JJ, Brooks, D & Logan, J 2025, 'Implications of Altered Endosomal-Lysosomal Biogenesis in Melanoma Pathogenesis', International Journal of Molecular Sciences, vol. 26, no. 20, article no. 10113, pp. 1-15. Open access
2024	Bader, CA, Simpson, P V, Dallerba, E, Stagni, S, Johnson, IR, Hickey, SM, Sorvina, A, Hackett, M, Sobolev, AN, Brooks, DA, Massi, M & Plush, SE 2024, 'Synthesis and cellular uptake of neutral rhenium(i) morpholine complexes', Dalton Transactions: An International Journal of Inorganic Chemistry, vol. 53, no. 7, pp. 3407-3413. 2 2
2024	Logan, JM, Martini, C, Sorvina, A, Johnson, IR, Brooks, RD, Caruso, MC, Huzzell, C, Moore, CR, Karageorgos, L, Butler, LM, Tewari, P, Prabhakaran, S, Hickey, SM, Klebe, S, Samaratunga, H, Delahunt, B, Moretti, K, O'Leary, JJ, Brooks, DA & Ung, BS 2024, 'Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers', Scientific Data, vol. 11, article no. 852, pp. 1-10. Open access 1
2024	Martini, C, Logan, JM, Sorvina, A, Prabhakaran, S, Ung, BS, Johnson, IR, Hickey, SM, Brooks, RD, Caruso, MC, Klebe, S, Karageorgos, L, O'Leary, JJ, Delahunt, B, Samaratunga, H & Brooks, DA 2024, 'Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer', Virchows Archiv, vol. 485, pp. 723-728. Open access 2 2
2023	Lam, GT, Martini, C, Brooks, T, Prabhakaran, S, Hopkins, AM, Ung, BS-Y, Tang, J, Caruso, MC, Brooks, RD, Johnson, IR, Sorvina, A, Hickey, SM, Karageorgos, L, Klebe, S, O'Leary, JJ, Brooks, DA & Logan, JM 2023, 'Insights into melanoma clinical practice: a perspective for future research', Cancers, vol. 15, no. 18, pp. 1-9. Open access 3 3
2023	Lam, GT, Sorvina, A, Martini, C, Prabhakaran, S, Ung, BS, Lazniewska, J, Moore, CR, Beck, AR, Johnson, IR, Caruso, MC, Hickey, SM, Brooks, RD, Karageorgos, L, Brooks, DA & Logan, JM and 6 other authors 2023, 'Altered endosomal-lysosomal biogenesis in melanoma', Neoplasia, vol. 43, article no. 100924, pp. 1-10. Open access 3 3 1
2023	Lazniewska, J, Li, KL, Johnson, IR, Sorvina, A, Logan, JM, Martini, C, Moore, C, Ung, BS, Karageorgos, L, Hickey, SM, Prabhakaran, S, Heatlie, JK, Brooks, RD, Huzzell, C, Warnock, N I, Moretti, P, Pitson, SM & Brooks, DA and 10 other authors 2023, 'Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression', Scientific Reports, vol. 13, no. 1, article no. 13489, pp. 1-18. Open access 12 11
2023	Logan, JM, Hopkins, AM, Martini, C, Sorvina, A, Huzzell, C, Johnson, IR, Hickey, SM, Ung, BS-Y, Lazniewska, J, Brooks, RD, Moore, CR, Caruso, MC, Karageorgos, L, Esterman, A, Moretti, K & Brooks, DA and 23 other authors 2023, 'Prediction of prostate cancer biochemical and clinical recurrence is improved by IHC-Assisted Grading using Appl1, Sortilin and Syndecan-1', Cancers, vol. 15, no. 12, pp. 1-12. Open access 9 8 122
2023	Martini, C, Logan, JM, Sorvina, A, Gordon, C, Beck, AR, Ung, BS, Caruso, MC, Moore, C, Johnson, IR, Li, KL, Karageorgos, L, Esterman, AJ, Huzzell, C, Brooks, RD, Lazniewska, J, Hickey, SM, Bader, CA, Parkinson-Lawrence, E, Prabhakaran, S, Moretti, KL & Brooks, DA and 28 other authors 2023, 'Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer', Pathology, vol. 55, no. 1, pp. 40-51. Open access 17 16 81
2023	Sorvina, A, Antoniou, M, Esmaeili, Z & Kochetkova, M 2023, 'Unusual suspects: bone and cartilage ECM proteins as carcinoma facilitators', Cancers, vol. 15, no. 3, article no. 791, pp. 1-24. Open access 4
2023	Sorvina, A, Martini, C, Prabhakaran, S, Logan, JM, Ung, BS-Y, Moore, C, Johnson, IR, Lazniewska, J, Tewari, P, Malone, V, Brooks, RD, Hickey, SM, Caruso, MC, Klebe, S, Karageorgos, L, O'Leary, JJ, Delahunt, B, Samaratunga, H & Brooks, DA 2023, 'Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread', Pathology, vol. 55, no. 6, pp. 792-799. Open access 9 9
2022	Hickey, SM, Ung, B, Bader, C, Brooks, R, Lazniewska, J, Johnson, IR, Sorvina, A, Logan, J, Martini, C, Moore, CR, Karageorgos, L, Sweetman, MJ & Brooks, DA 2022, 'Fluorescence microscopy-an outline of hardware, biological handling, and fluorophore considerations', Cells, vol. 11, no. 35, pp. 1-32. Open access 84 68 1
2022	Johnson, IR, Rudebeck, EE, Sweetman, MJ, Sorvina, A, Ashton, TD, Pfeffer, FM, Brooks, DA & Hickey, SM 2022, 'A 3,4-dimethoxy-1,8-naphthalimide for lipid droplet imaging in live and fixed cells', Sensors and Actuators B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, vol. 365, article no. 131921, pp. 1-7. Open access 10 8 1
2022	Lam, GT, Prabhakaran, S, Sorvina, A, Martini, C, Ung, BS, Karageorgos, L, Hickey, SM, Lazniewska, J, Johnson, IR, Williams, DB, Klebe, S, Malone, V, O'Leary, JJ, Jackett, L, Brooks, DA & Logan, JM 2022, 'Pitfalls in cutaneous melanoma diagnosis and the need for new reliable markers', Molecular Diagnosis and Therapy, vol. 27, no. 1, pp. 49-60. Open access 12 11 42
2022	Zhang, WQ, Sorvina, A, Morrison, JL, Darby, JR, Brooks, DA, Plush, SE & Afshar Vahid, S 2022, 'Development of an optical fiber-based redox monitoring system for tissue metabolism', Journal of Biophotonics, vol. 15, no. 4, article no. e202100304, pp. 1-11. Open access 2 2 1
2021	Dimasi, CG, Lazniewska, J, Plush, SE, Saini, BS, Holman, SL, Cho, SK, Wiese, MD, Sorvina, A, Macgowan, CK, Seed, M, Brooks, DA, Morrison, JL & Darby, JR 2021, 'Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output', Journal of Biophotonics, vol. 14, no. 12, article no. e202100157, pp. 1-13. Open access 16 16 6
2021	Gillam, TA, Caporale, C, Brooks, RD, Bader, CA, Sorvina, A, Werrett, M V, Wright, PJ, Morrison, JL, Massi, M, Brooks, DA, Zacchini, S, Hickey, SM, Stagni, S & Plush, SE 2021, 'Neutral Re(I) complex platform for live intracellular imaging', Inorganic Chemistry: Including Bioinorganic Chemistry, vol. 60, no. 14, pp. 10173-10185. 13 13 9
2021	Lazniewska, J, Darby, JR, Holman, SL, Sorvina, A, Plush, SE, Massi, M, Brooks, DA & Morrison, JL 2021, 'In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat', Journal of Biophotonics, vol. 14, no. 4, article no. e202000322, pp. 1-13. Open access 4 3 1
2020	Darby, JR, Sorvina, A, Bader, CA, Lock, MC, Soo, JY, Holman, SL, Seed, M, Kuchel, T, Brooks, DA, Plush, SE & Morrison, JL 2020, 'Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissue', Journal of Biophotonics, 13, no. 3, article no. e201960085, pp. 1-13. Open access 16 17 3
2020	Sorvina, A, Shandala, T, Wang, S, Sharkey, DJ, Parkinson-Lawrence, E, Selemidis, S & Brooks, DA 2020, 'CDKI-73 Is a novel pharmacological inhibitor of Rab11 cargo delivery and innate immune secretion', Cells, vol. 9, no. 2, article no. 372, pp. 1-17. Open access 9 8 1
2019	Johnson, IR, Sorvina, A, Logan, JM, Moore, CR, Heatlie, JK, Parkinson-Lawrence, EJ, Selemidis, S, O'leary, JJ, Butler, LM & Brooks, DA 2019, 'A paradigm in immunochemistry, revealed by monoclonal antibodies to spatially distinct epitopes on syntenin-1', International Journal of Molecular Sciences, vol. 20, no. 23, pp. 1-16. Open access 5 5 1
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of Biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. Open access 5 6 4
2018	Sorvina, A, Bader, C, Lock, MC, Brooks, DA, Morrison, JL & Plush, SE 2018, 'Label-free imaging of healthy and infarcted fetal sheep hearts by two-photon microscopy', Journal of Biophotonics, vol. 11, no. 1, article no. e201600296, pp. 1-8. Open access 6 4 3
2018	Sorvina, A, Bader, CA, Caporale, C, Carter, EA, Johnson, IR, Parkinson-Lawrence, EJ, Simpson, P V, Wright, PJ, Stagni, S, Lay, PA, Massi, M, Brooks, DA & Plush, SE 2018, 'Lipid profiles of prostate cancer cells', Oncotarget, vol. 9, no. 85, pp. 35541-35552. Open access 39 5
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 33 28 9
2017	Caporale, C, Bader, CA, Sorvina, A, Magee, KD, Skelton, BW, Gillam, TA, Wright, PJ, Raiteri, P, Stagni, S, Morrison, JL, Plush, SE, Brooks, DA & Massi, M 2017, 'Investigating intracellular localisation and cytotoxicity trends for neutral and cationic iridium tetrazolato complexes in live cells', Chemistry: A European Journal, vol. 23, no. 62, pp. 15666-15679. Open access 53 49 16
2017	Ng, YS, Sorvina, A, Bader, CA, Weiland, F, Lopez, AF, Hoffmann, P, Shandala, T & Brooks, DA 2017, 'Proteome Analysis of drosophila mutants identifies a regulatory role for 14-3-3ϵ in metabolic pathways', Journal of Proteome Research, vol. 16;vol. 16, no. 5, pp. 1976-1987. 1 1 2
2017	Stevens, K, Bader, C, Sorvina, A, Plush, S & Morrison, J 2017, 'Imaging and lipidomics methods for lipid analysis in metabolic and cardiovascular disease', Journal of Developmental Origins of Health and Disease, vol. 8, no. 5, pp. 566-574. Open access 4 4
2016	Bader, CA, Sorvina, A, Simpson, P V, Wright, PJ, Stagni, S, Plush, SE, Massi, M & Brooks, DA 2016, 'Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time', FEBS Letters, vol. 590, no. 18, pp. 3051-3060. Open access 25 23 8
2016	Sorvina, A, Shandala, T & Brooks, D 2016, 'Drosophila Pkaap regulates Rab4/Rab11-dependent traffic and Rab11 exocytosis of innate immune cargo', Biology Open, vol. 5, no. 6, pp. 678-688. Open access 6 6 1
2014	Bader, CA, Brooks, RD, Ng, YS, Sorvina, A, Werrett, M V, Wright, PJ, Anwer, AG, Brooks, DA, Stagni, S, Muzzioli, S, Silberstein, M, Skelton, BW, Goldys, EM, Plush, SE, Shandala, T & Massi, M 2014, 'Modulation of the organelle specificity in Re(i) tetrazolato complexes leads to labeling of lipid droplets', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 4, no. 31, pp. 16345-16351. Open access 54 49
2013	Shandala, T, Lim, CX, Sorvina, A & Brooks, DA 2013, 'A Drosophila model to image phagosome maturation', Cells, vol. 2, no. 2, pp. 188-201. Open access 8
2013	Sorvina, A, Brooks, DA, Ng, YS, Bader, CA, Weigert, R & Shandala, T 2013, 'Bacterial challenge initiates endosome-lysosome response in Drosophila immune tissues', IntraVital, vol. 2, no. 1, pp. 1-12. Open access
2010	Chernov, V, Chernova, O, Medvedeva, E, Sorvina, A, Davydova, M, Rogova, M & Serebryakova, M 2010, 'Responses of Acholeplasma laidlawii PG8 cells to cold shock and oxidative stress: Proteomic analysis and stress-reactive mycoplasma proteins', Doklady Biochemistry and Biophysics, vol. 432, no. 1, pp. 126-130. 8 8

Conferences

Year	Output
2017	Zhang, WQ, Morrison, JL, Darby, JR, Plush, S, Sorvina, A, Brooks, D, Monro, TM & Afshar Vahid, S 2017, 'A fibre optic fluorescence sensor to measure redox level in tissues', Nanophotonics Australasia 2017, SPIE, vol. 10456, article no. 104564R, pp. 1-6.

Non Traditional Outputs

Year	Output
2019	Ung, B, Logan, J, Sorvina, A, Martino, C, Prabhakaran, S, Karageorgos, L & Brooks, D 2019, Prostate cancer biomarker atlas.

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Austin Health	AUSTRALIA
Curtin University	AUSTRALIA
Deakin University	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Macquarie University	AUSTRALIA
Malaghan Institute of Medical Research	NEW ZEALAND
Monash University	AUSTRALIA
National Institute of Health	ARMENIA
Research Institute of Physicochemical Medicine	RUSSIAN FEDERATION
RMIT University	AUSTRALIA
Russian Academy of Sciences	RUSSIAN FEDERATION
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
South Australian Health and Medical Institute	AUSTRALIA
The Coombe Hospital	IRELAND
The Hospital for Sick Children	CANADA
Trinity College Dublin	IRELAND
University of Adelaide	AUSTRALIA
University of Bologna	ITALY
University of Dublin	IRELAND
University of Melbourne	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Western Australia	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
The role of membrane trafficking in prostate cancer metastasis	Current
Design, in silico assessment, and synthesis of quinoxaline platinum complexes as ATPase competitive topoisomerase inhibitors	Completed
Endosomal-lysosomal biomarkers to define melanoma pathogenesis	Completed

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Dr Alexandra Sorvina

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

Conferences

Non Traditional Outputs

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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