Dr Amanda Lumsden

Research Fellow UniSA Clinical & Health Sciences

email Amanda.Lumsden@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Clinical Sciences
Neurosciences
Medical and Health Sciences
Nutrition and Dietetics
Biochemistry and Cell Biology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2025	Yeshaw, Y, Madakkatel, I, Mulugeta, A, Lumsden, A & Hypponen, E 2025, 'Machine learning to discover factors predicting volume of white matter hyperintensities: insights from the UK Biobank', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 17, no. 1, article no. e70090, pp. 1-12. Open access
2024	Madakkatel, I, Lumsden, AL, Mulugeta, A, Maenpaa, J, Oehler, MK & Hyppönen, E 2024, 'Large-scale analysis to identify risk factors for ovarian cancer', International Journal of Gynecological Cancer, online, pp. 1-9. Open access 3 4 170
2024	Mulugeta, A, Lumsden, A, Madakkatel, I, Stacey, D, Lee, SH, Mäenpää, J, Oehler, M & Hypponen, E 2024, 'Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers', Cancer Medicine, vol. 13, no. 4, article no. e7051, pp. 1-13. Open access 2
2024	Yalew, M, Mulugeta, A, Lumsden, AL, Madakkatel, I, Lee, SH, Oehler, MK, Maenpaa, J & Hyppönen, E 2024, 'Circulating phylloquinone and the risk of four female-specific cancers: a mendelian randomization study', Nutrients, vol. 16, no. 21, article no. 3680, pp. 1-9. Open access
2024	Yeshaw, Y, Madakkatel, MI, Mulugeta, A, Lumsden, A & Hyppönen, E 2024, 'Uncovering predictors of low hippocampal volume: evidence from a large-scale machine-learning-based study in the UK biobank', Neuroepidemiology, vol. 58, pp. 369-382. Open access
2023	Ahmed, M, Mäkinen, VP, Lumsden, A, Boyle, T, Mulugeta, A, Lee, SH, Olver, I & Hyppönen, E 2023, 'Metabolic profile predicts incident cancer: a large-scale population study in the UK Biobank', Metabolism: Clinical and Experimental, vol. 138, article no. 155342. Open access 6 6 4
2023	Jones, LA, Sun, EW, Lumsden, AL, Thorpe, DW, Peterson, RA, De Fontgalland, D, Sposato, L, Rabbitt, P, Hollington, P, Wattchow, DA & Keating, DJ 2023, 'Alterations in GLP-1 and PYY release with aging and body mass in the human gut', Molecular and Cellular Endocrinology, vol. 578, article no. 112072, pp. 1-6. Open access 6 4 6
2023	Lumsden, AL, Mulugeta, A, Makinen, V-P & Hypponen, E 2023, 'Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition', Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, vol. 25, no. 1, pp. 121-131. Open access 6 6 127
2023	Madakkatel, I, Lumsden, AL, Mulugeta, A, Olver, I & Hypponen, E 2023, 'Hypothesis-free discovery of novel cancer predictors using machine learning', European Journal of Clinical Investigation, vol. 53, no. 10, article no. e14037, pp. 1-13. Open access 4 4 39
2023	Pham, K, Mulugeta, A, Lumsden, A & Hyppӧnen, E 2023, 'Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank', British Journal of Clinical Pharmacology, vol. 89, no. 10, pp. 2992-3004. Open access 2 2 97
2022	Ashander, LM, Lumsden, AL, Dawson, AC, Ma, Y, Ferreira, LB, Oliver, GF, Appukuttan, B, Carr, JM & Smith, JR 2022, 'Infection of human retinal pigment epithelial cells with dengue virus strains isolated during outbreaks in Singapore', Microorganisms, vol. 10, no. 2, article no. 310, pp. 1-14. Open access 8 7 4
2022	Castro, J, Garcia-Caraballo, S, Maddern, J, Schober, G, Lumsden, A, Harrington, A, Schmiel, S, Lindstrom, B, Adams, J & Brierley, SM 2022, 'Olorinab (APD371), a peripherally acting, highly selective, full agonist of the cannabinoid receptor 2, reduces colitis-induced acute and chronic visceral hypersensitivity in rodents', Pain, vol. 163, no. 1, pp. E72-E86. Open access 21 21 7
2022	Lumsden, AL, Mulugeta, A & Hyppönen, E 2022, 'Milk consumption and risk of twelve cancers: a large-scale observational and Mendelian randomisation study', Clinical Nutrition, vol. 42, no. 1, pp. 1-8. Open access 19 16 23
2022	Mulugeta, A, Eshetie, TC, Kassie, GM, Erku, D, Mekonnen, A, Lumsden, A & Hypponen, E 2022, 'Association between metabolically different adiposity subtypes and osteoarthritis: a Mendelian Randomization Study', Arthritis Care and Research, vol. 75, no. 4, pp. 885-892. Open access 7 5 3
2022	Mulugeta, A, Navale, SS, Lumsden, AL, Llewellyn, DJ & Hyppönen, E 2022, 'Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank', Nutrients, vol. 14, no. 19, article no. 3907, pp. 1-13. Open access 9 9 5
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Relationship between serum 25(Oh)d and depression: causal evidence from a bi-directional mendelian randomization study', Nutrients, vol. 13, no. 1, pp. 1-13. Open access 21 21 29
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: a Mendelian randomization study', Neurobiology of Aging, vol. 102, pp. 161-169. Open access 18 18 80
2021	Sun, EW, Iepsen, EW, Pezos, N, Lumsden, AL, Martin, AM, Schober, G, Isaacs, NJ, Rayner, CK, Nguyen, NQ, de Fontgalland, D, Rabbitt, P, Hollington, P, Wattchow, DA, Hansen, T, Holm, J-C, Liou, AP, Jackson, VM, Torekov, SS, Young, RL & Keating, DJ 2021, 'A gut-intrinsic melanocortin signaling complex augments L-cell secretion in humans', Gastroenterology, vol. 161, no. 2, pp. 536-547.e2. 13 13 7
2020	Grundy, L, Caldwell, A, Lumsden, A, Mohammadi, E, Hannig, G, Greenwood Van-Meervald, B & Brierley, SM 2020, 'Experimentally induced bladder permeability evokes bladder afferent hypersensitivity in the absence of inflammation', Frontiers in Neuroscience, vol. 14, article no. 590871, pp. 1-10. Open access 14 12 7
2020	Hin, N, Newman, M, Kaslin, J, Douek, AM, Lumsden, A, Nik, SHM, Dong, Y, Manucat-Tan, NB, Ludington, A, Adelson, DL, Pederson, S & Lardelli, M 2020, 'Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2', PLoS One, vol. 15, no. 1, article no. e0227258, pp. 1-36. Open access 24 22 16
2020	Lumsden, AL, Mulugeta, A, Zhou, A & Hyppönen, E 2020, 'Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank', EBioMedicine, vol. 59, article no. 102954, pp. 1-11. Open access 180 169 82
2019	Castro, J, Harrington, AM, Lieu, T, Garcia-Caraballo, S, Maddern, J, Schober, G, O'Donnell, T, Grundy, L, Lumsden, AL, Miller, P, Ghetti, A, Steinhoff, MS, Poole, DP, Dong, X, Chang, L, Bunnett, NW & Brierley, SM 2019, 'Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity', JCI insight, vol. 4, no. 20, article no. e131712, pp. 1-24. Open access 59 60 67
2019	Lumsden, AL, Martin, AM, Sun, EW, Schober, G, Isaacs, NJ, Pezos, N, Wattchow, DA, de Fontgalland, D, Rabbitt, P, Hollington, P, Sposato, L, Due, SL, Rayner, CK, Nguyen, NQ, Liou, AP, Jackson, VM, Young, RL & Keating, DJ 2019, 'Sugar responses of human enterochromaffin cells depend on gut region, sex, and body mass', Nutrients, vol. 11, no. 2, article no. 234, pp. 1-13. Open access 21 21 18
2018	Lumsden, AL, Ma, Y, Ashander, LM, Stempel, AJ, Keating, DJ, Smith, JR & Appukuttan, B 2018, 'ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells', BMC Research Notes, vol. 11, article no. 285, pp. 1-8. Open access 4 1
2018	Lumsden, AL, Rogers, JT, Majd, S, Newman, M, Sutherland, GT, Verdile, G & Lardelli, M 2018, 'Dysregulation of neuronal iron homeostasis as an alternative unifying effect of mutations causing familial Alzheimer's disease', Frontiers in Neuroscience, vol. 12, article no. 533, pp. 1-21. Open access 38 35 86
2018	Young, RL, Lumsden, AL, Martin, AM, Schober, G & Keating, DJ and 16 others 2018, 'Augmented capacity for peripheral serotonin release in human obesity', International Journal of Obesity, vol. 42, no. 11, pp. 1880-1889. 69 59 54
2017	Martin, A, Lumsden, A, Young, R, Jessup, C, Spencer, N & Keating, D 2017, 'The nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon', Neurogastroenterology and Motility, vol. 29, no. 6, pp. 1-8. Open access 57 49 2
2017	Martin, AM, Lumsden, AL, Young, RL, Jessup, CF, Spencer, NJ & Keating, DJ 2017, 'Regional differences in nutrient-induced secretion of gut serotonin', Physiological Reports, vol. 5, no. 6, article no. e13199, pp. 1-12. Open access 72 40 1
2016	Lumsden, AL, Young, RL, Pezos, N & Keating, DJ 2016, 'Huntingtin-associated protein 1: eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine', BMC Evolutionary Biology, vol. 16, article no. 214, pp. 1-18. Open access 8 9 3
2016	Mackenzie, KD, Lumsden, A, Guo, F, Duffield, MD, Chataway, T, Lim, Y, Zhou, X-F & Keating, DJ 2016, 'Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking', Journal of Neurochemistry, vol. 138, no. 5, pp. 710-721. Open access 22 22 1
2016	Raghupathi, R, Jessup, CF, Lumsden, AL & Keating, DJ 2016, 'Fusion pore size limits 5-HT release from single enterochromaffin cell vesicles', Journal of Cellular Physiology, vol. 231, no. 7, pp. 1593-1600. 20 19
2015	Zelkas, L, Raghupathi, R, Lumsden, AL, Martin, AM, Sun, E, Spencer, NJ, Young, RL & Keating, DJ 2015, 'Serotonin-secreting enteroendocrine cells respond via diverse mechanisms to acute and chronic changes in glucose availability', Nutrition and Metabolism, vol. 12, article no. 55, pp. 1-9. Open access 41 38 1
2011	Myre, MA, Lumsden, AL, Thompson, MN, Wasco, W, MacDonald, ME & Gusella, JF 2011, 'Deficiency of huntingtin has pleiotropic effects in the social amoeba dictyostelium discoideum', PLoS Genetics, vol. 7, no. 4, article no. e1002052, pp. 1-17. Open access 49 43
2009	Henshall, TL, Tucker, B, Lumsden, AL, Nornes, S, Lardelli, MT & Richards, R I 2009, 'Selective neuronal requirement for huntingtin in the developing zebrafish', Human Molecular Genetics, vol. 18, no. 24, pp. 4830-4842. Open access 41 37

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
AnaBios Corporation	UNITED STATES
Arena Pharmaceuticals	UNITED STATES
Curtin University	AUSTRALIA
David Geffen School of Medicine at UCLA	UNITED STATES
Deakin University	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Griffith University	AUSTRALIA
Harvard University	UNITED STATES
Ironwood Pharmaceuticals	UNITED STATES
Johns Hopkins University	UNITED STATES
Massachusetts General Hospital	UNITED STATES
Monash University	AUSTRALIA
Pfizer Worldwide Research and Development	UNITED STATES
Qatar University	QATAR
Royal Adelaide Hospital	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Tampere University	FINLAND
University of Adelaide	AUSTRALIA
University of Copenhagen	DENMARK
University of Exeter	UNITED KINGDOM
University of Melbourne	AUSTRALIA
University of Oklahoma Health Sciences Center	UNITED STATES
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Washington	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Mr Baillieu Myer AC Award - Special Award for Best Poster for its Innovative Contribution to AlzheimerÂ¿s Research Australian Dementia Research Forum/Dementia Australia	2022
Reviewer Inorganics	2021
Reviewer British Journal of Pharmacology	2021
Reviewer Pharmaceuticals	2021
Reviewer Molecules	2021
Reviewer Journal of Endocrinological Investigation	2021
Reviewer Neurochemical Research	2021
Reviewer Inorganics	2020
Reviewer Pharmaceuticals	2020
Reviewer Journal of Endocrinological Investigation	2020
Reviewer Neurochemical Research	2020
Reviewer British Journal of Pharmacology	2020
Reviewer Molecules	2020
Invited Speaker Dementia, Ageing and Neurodegenerative Diseases group (DANDIS)	2019
Reviewer Inorganics	2019
Reviewer Molecules	2019
Reviewer Neurochemical Research	2019
Reviewer British Journal of Pharmacology	2019
Reviewer Journal of Endocrinological Investigation	2019
Reviewer Pharmaceuticals	2019
Reviewer Inorganics	2018
Reviewer Pharmaceuticals	2018
Reviewer Molecules	2018
Reviewer Journal of Endocrinological Investigation	2018
Reviewer Neurochemical Research	2018
Reviewer British Journal of Pharmacology	2018
Committee member FUSA Early-Mid Career Researcher	2016
Committee member Australian Physiological Society	2016
Committee member FUSA Early-Mid Career Researcher	2015
Committee member FUSA Early-Mid Career Researcher	2014

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Improving genetic prediction of ovarian cancer risk	Current
Predicting brain health and dementia: a machine learning approach	Current
Exploring the effects of serum lipids, cholesterol lowering medications and coffee on health: observational and genetic studies	Completed

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Dr Amanda Lumsden

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Mr Baillieu Myer AC Award - Special Award for Best Poster for its Innovative Contribution to AlzheimerÂ¿s Research

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