Dr Andrea Stringer

Senior Lecturer/Senior Research Fellow School of Pharmacy and Medical Sciences

City East Campus (P1-16)
tel +61 8 830 21760

City West Campus (HB6-18)
tel +61 8 830 27388

email Andrea.Stringer@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

Cancer
Toxicities
Inflammation
Gut
Vitamin D

Dr Andrea Stringer leads research focussing on the role of the intestine related to vitamin D with musculoskeletal outcomes. Andrea's broad area of research has focussed primarily on gut function, with the focus of this now on the gut-bone axis and the role of the gut microbiome in this environment. She works closely with the Musculoskeletal Biology Research Group.

Andrea's broad area of expertise is in developing strategies for preventing or treating oral and gastrointestinal damage following cancer treatments (mucositis) to reduce the burden of cancer. She has been involved in multiple pre-clinical investigations with growth factors, and probiotics to investigate their effectiveness in treating cancer treatment-induced... Read more

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Research

Research themes

An age friendly world
Cancer
Healthy futures

Research focus

Medical and Health Sciences
Pharmacology and Pharmaceutical Sciences
Oncology and Carcinogenesis
Biological Sciences
Clinical Sciences

Highlights

My current research focusses on the digestive tract. The two streams of work are the undesirable effects of cancer therapy (those other than curing the cancer), and the role of the intestine in vitamin D metabolism and bone health and repair. My current projects are:

- damage to tissue along the entire digestive tract, including the mouth, and the role of endogenous microbiota and inflammatory signalling following cancer therapy

- intestinal function related to vitamin D synthesis in the intestine and the downstream effects on bone, and the effects of vitamin D on the intestine.

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2019	Hedelin, M, Skokic, V, Wilderang, U, Ahlin, R, Bull, C, Sjoberg, F, Dunberger, G, Bergmark, K, Stringer, A & Steineck, G 2019, 'Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors', PLoS One, vol. 14, no. 1, article no. e0208115, pp. 1-18. Open access 1
2015	Stringer, AM & Logan, RM 2015, 'The role of oral flora in the development of chemotherapy-induced oral mucositis', Journal Of Oral Pathology and Medicine, vol. 44, no. 2, pp. 81-87. Open access 13 29 3
2015	Vanhoecke, BW & Stringer, A 2015, 'Host-microbe cross talk in cancer therapy', Current Opinion in Supportive and Palliative Care, vol. 9, no. 2, pp.174-181. 7 7 1
2013	Stringer, AM 2013, 'Interaction between host cells and microbes in chemotherapy-induced mucositis', Nutrients, vol. 5, no. 5, pp. 1488-1499. Open access 31 31 2
2013	Stringer, AM, Al-Dasooqi, N, Bowen, JM, Tan, TH, Radzuan, M, Logan, RM, Mayo, B, Keefe, DMK & Gibson, RJ 2013, 'Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases', Supportive Care in Cancer, vol. 21, no. 7, pp. 1843-1852. 53 51

Journal Articles

Year	Output
2019	Bowen, J, Al-Dasooqi, N, Bossi, P, Wardill, H, Van Sebille, Y, Al-Azri, A, Bateman, E, Correa, M, Raber-Durlacher, J, Kandwal, A, Mayo, B, Nair, R, Stringer, A, ten Bohmer, K, Thorpe, D, Lalla, R, Sonis, S, Cheng, K & Elad, S 2019, 'The pathogenesis of mucositis: updated perspectives and emerging targets', Supportive Care in Cancer, vol. 27, no. 10, pp. 4023-4033. 2 1 9
2019	Bowen, JM, Gibson, RJ, Coller, JK, Blijlevens, N, Bossi, P, Al-Dasooqi, N, Bateman, EH, Chiang, K, de Mooij, C, Mayo, B, Stringer, AM, Tissing, W, Wardill, HR, van Sebille, YZ, Ranna, V, Vaddi, A, Keefe, DM, Lalla, R V, Cheng, KKF & Elad, S 2019, 'Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines', Supportive Care in Cancer, vol. 27, no. 10, pp. 4011-4022. 1
2019	Hassanshahi, M, Anderson, PH, Sylvester, CL & Stringer, AM 2019, 'Current evidence for vitamin D in intestinal function and disease', Experimental Biology and Medicine, vol. 244, no. 12, pp. 1-13. 2
2019	Hedelin, M, Skokic, V, Wilderang, U, Ahlin, R, Bull, C, Sjoberg, F, Dunberger, G, Bergmark, K, Stringer, A & Steineck, G 2019, 'Intake of citrus fruits and vegetables and the intensity of defecation urgency syndrome among gynecological cancer survivors', PLoS One, vol. 14, no. 1, article no. e0208115, pp. 1-18. Open access 1
2019	Malipatlolla, DK, Patel, P, Sjöberg, F, Devarakonda, S, Kalm, M, Angenete, E, Lindskog, EB, Grandér, R, Persson, L, Stringer, A, Wilderäng, U, Swanpalmer, J, Kuhn, HG, Steineck, G & Bull, C 2019, 'Long-term mucosal injury and repair in a murine model of pelvic radiotherapy', Scientific Reports, vol. 9, article no. 13803, pp. 1-10. Open access
2019	Thorpe, D, Butler, R, Sultani, M, Vanhoecke, B & Stringer, A 2019, 'Irinotecan-induced mucositis is associated with goblet cell dysregulation and neural cell damage in a tumour bearing DA rat model', Pathology and Oncology Research, online, pp. 1-11. 1
2019	Thorpe, D, Sultani, M & Stringer, A 2019, 'Irinotecan induces enterocyte cell death and changes to muc2 and muc4 composition during mucositis in a tumour-bearing DA rat model', Cancer Chemotherapy and Pharmacology, vol. 83, no. 5, pp. 893-904. 1
2019	Wardill, HR, Tissing, WJ, Kissow, H & Stringer, AM 2019, 'Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets', Current Opinion in Supportive and Palliative Care, vol. 13, no. 2, pp. 119-133. 2
2018	Johnson, ME, Stringer, A & Bobrovskaya, L 2018, 'Rotenone induces gastrointestinal pathology and microbiota alterations in a rat model of Parkinson's disease', NeuroToxicology, vol. 65, pp.174-185. Open access 12 13 10
2018	Mahendran, VJ, Stringer, AM, Semple, SJ, Song, Y & Garg, S 2018, 'Advances in the use of anti-inflammatory agents to manage chemotherapy-induced oral and gastrointestinal mucositis', Current Pharmaceutical Design, vol. 24, no. 14, pp. 1518-1532. 3 3
2018	Stansborough, RL, Al-Dasooqi, N, Bateman, EH, Bowen, JM, Keefe, DM, Logan, RM, Yeoh, AS, Yeoh, EE, Stringer, AM & Gibson, RJ 2018, 'Matrix metalloproteinase expression is altered in the small and large intestine following fractionated radiation in vivo', Supportive Care in Cancer, vol. 26, no. 11, pp. 3873–3882. 3 4
2018	Stansborough, RL, Bateman, EH, Al-Dasooqi, N, Bowen, JM, Wignall, A, Keefe, DM, Yeoh, AS, Logan, RM, Yeoh, EE, Stringer, AM & Gibson, RJ 2018, 'Vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFβ), angiostatin, and endostatin are increased in radiotherapy-induced gastrointestinal toxicity', International Journal of Radiation Biology, vol. 94, no. 7, pp. 645-655. 1 1
2017	Stansborough, RL, Bateman, EH, Al-Dasooqi, N, Bowen, JM, Keefe, DM, Yeoh, AS, Logan, RM, Yeoh, EE, Stringer, AM & Gibson, RJ 2017, 'Fractionated abdominal irradiation induces intestinal microvascular changes in an in vivo model of radiotherapy-induced gut toxicity', Supportive Care in Cancer, vol. 25, no. 6, pp. 1973-1983. 8 8
2017	Vanlancker, E, Vanhoecke, B, Stringer, A & Van de Wiele, T 2017, '5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition in vitro', PEERJ, vol. 2017, no. 11, article no.e4017, pp. 1-20. Open access 5 4 1
2016	Mayo, BJ, Stringer, AM, Bowen, JM, Bateman, EH & Keefe, DM 2016, 'Irinotecan-induced mucositis: the interactions and potential role of GLP-2 analogues', Cancer Chemotherapy and Pharmacology, online, pp. 1-17. 10 9 1
2015	Al-Azri, AR, Gibson, RJ, Bowen, JM, Stringer, AM, Keefe, DM & Logan, RM 2015, 'Involvement of matrix metalloproteinases (MMP-3 and MMP-9) in the pathogenesis of irinotecan-induced oral mucositis', Journal Of Oral Pathology and Medicine, vol. 44, no. 6, pp. 459-467. 16 15
2015	Stringer, AM & Logan, RM 2015, 'The role of oral flora in the development of chemotherapy-induced oral mucositis', Journal Of Oral Pathology and Medicine, vol. 44, no. 2, pp. 81-87. Open access 13 29 3
2015	Vanhoecke, B, Bateman, E, Mayo, B, Vanlancker, E, Stringer, A, Thorpe, D & Keefe, D 2015, 'Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art', Experimental Biology and Medicine, vol. 240, no. 6, pp. 725-741. Open access 10 9
2015	Vanhoecke, B, De Ryck, T, Stringer, A, Van de Wiele, T & Keefe, D 2015, 'Microbiota and their role in the pathogenesis of oral mucositis', Oral Diseases, vol. 21, no. 1, pp. 17-30. 33 28 1
2015	Vanhoecke, BW & Stringer, A 2015, 'Host-microbe cross talk in cancer therapy', Current Opinion in Supportive and Palliative Care, vol. 9, no. 2, pp.174-181. 7 7 1
2014	Bowen, JM, Mayo, BJ, Plews, E, Bateman, E, Wignall, A, Stringer, AM, Boyle, FM & Keefe, DM 2014, 'Determining the mechanisms of lapatinib-induced diarrhoea using a rat model', Cancer Chemotherapy and Pharmacology, vol. 74, no. 3, pp. 617-627. 5 10
2013	Al-Dasooqi, N, Sonis, ST, Bowen, JM, Bateman, E, Blijlevens, N, Gibson, RJ, Logan, RM, Nair, RG, Stringer, AM, Yazbeck, R, Elad, S & Lalla, R V 2013, 'Emerging evidence on the pathobiology of mucositis', Supportive Care in Cancer, vol. 21, no. 7, pp. 2075-2083. 53 61
2013	Bateman, E, Bowen, J, Stringer, A, Mayo, B, Plews, E, Wignall, A, Greenberg, N, Schiffrin, E & Keefe, D 2013, 'Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model', Nutrients, vol. 5, no. 10, pp. 3948-3963. Open access 6 7 1
2013	Gibson, RJ, Keefe, DMK, Lalla, R V, Bateman, E, Blijlevens, N, Fijlstra, M, King, EE, Stringer, AM, van der Velden, WJFM, Yazbeck, R, Elad, S & Bowen, JM 2013, 'Systematic review of agents for the management of gastrointestinal mucositis in cancer patients', Supportive Care in Cancer, vol. 21, no. 1, pp. 313-326. Open access 125 114 14
2013	Stringer, AM 2013, 'Interaction between host cells and microbes in chemotherapy-induced mucositis', Nutrients, vol. 5, no. 5, pp. 1488-1499. Open access 31 31 2
2013	Stringer, AM, Al-Dasooqi, N, Bowen, JM, Tan, TH, Radzuan, M, Logan, RM, Mayo, B, Keefe, DMK & Gibson, RJ 2013, 'Biomarkers of chemotherapy-induced diarrhoea: a clinical study of intestinal microbiome alterations, inflammation and circulating matrix metalloproteinases', Supportive Care in Cancer, vol. 21, no. 7, pp. 1843-1852. 53 51
2013	Thorpe, D, Stringer, A & Butler, R 2013, 'Chemotherapy-induced mucositis : the role of mucin secretion and regulation, and the enteric nervous system', NeuroToxicology, vol. 38, pp. 101-105. 13 10
2013	Thorpe, DW, Stringer, AM & Gibson, RJ 2013, 'Chemotherapy-induced mucositis: the role of the gastrointestinal microbiome and toll-like receptors', Experimental Biology and Medicine, vol. 238, no. 1, pp. 1-6. 18 18
2012	Bowen, JM, Mayo, BJ, Plews, E, Bateman, E, Stringer, AM, Boyle, FM, Finnie, JW & Keefe, DM 2012, 'Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea', Cancer Biology and Therapy, vol. 13, no. 13, pp. 1269-1275. Open access 17 19
2012	Sultani, M, Stringer, AM, Bowen, JM & Gibson, RJ 2012, 'Anti-inflammatory cytokines : important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis', ChemoTherapy Research and Practice, vol. 2012, article no. 490804. Open access 1
2011	Al-Dasooqi, N, Bowen, JM, Gibson, RJ, Logan, RM, Stringer, AM & Keefe, DM 2011, 'Irinotecan-induced alterations in intestinal cell kinetics and extracellular matrix component expression in the dark agouti rat', International Journal of Experimental Pathology, vol. 92, no. 5, pp. 357-365. Open access 23 21
2011	Al-Dasooqi, N, Bowen, JM, Gibson, RJ, Logan, RM, Stringer, AM & Keefe, DM 2011, 'Selection of housekeeping genes for gene expression studies in a rat model of irinotecan-induced mucositis', ChemoTherapy: International Journal of Experimental and Clinical ChemoTherapy, vol. 57 no. 1, pp. 43-53. 10 12
2011	Keefe, D, Bowen, J, Gibson, R, Tan, T, Odera, M & Stringer, A 2011, 'Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: a review', Oncologist, vol. 16, no. 4, pp. 432-444. Open access 63 53
2010	Al-Dasooqi, N, Gibson, RJ, Bowen, JM, Logan, RM, Stringer, AM & Keefe, DM 2010, 'Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat', Experimental Biology and Medicine, vol. 235, no. 10, pp. 1244-1256. 40 36
2010	Bowen, JM, Tyskin, A, Stringer, AM, Logan, RM, Gibson, RJ & Keefe, DM 2010, 'Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract', Toxicology, vol. 269, no. 1, pp. 1-12. 8 6
2010	Ong, ZY, Gibson, RJ, Bowen, JM, Stringer, AM, Darby, JM, Logan, RM, Yeoh, AS & Keefe, DM 2010, 'Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis', Radiation Oncology, vol. 5, no. 1, article no. 22, pp. 1-8. Open access 73 71
2009	Gibson, RJ & Stringer, AM 2009, 'Chemotherapy-induced diarrhoea', Current Opinion in Supportive and Palliative Care, vol. 3, no. 1, pp. 31-35. 40
2009	Logan, RM, Stringer, AM, Bowen, JM, Gibson, RJ, Sonis, ST & Keefe, DM 2009, 'Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?', Cancer Chemotherapy and Pharmacology, vol. 63, no. 2, pp. 239-251. 97 89
2009	Stringer, AM, Gibson, RJ, Bowen, JM & Keefe, DM 2009, 'Chemotherapy-Induced Modifications to Gastrointestinal Microflora: Evidence and Implications of Change', Current Drug Metabolism, vol. 10, pp. 79-83. 74 65
2009	Stringer, AM, Gibson, RJ, Bowen, JM, Logan, RM, Ashton, K, Yeoh, ASJ, Al-Dasooqi, N & Keefe, DMK 2009, 'Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile', International Journal of Experimental Pathology, vol. 90, no. 5, pp. 489-499. Open access 81 73
2009	Stringer, AM, Gibson, RJ, Logan, RM, Bowen, JM, Yeoh, AS, Hamilton, J & Keefe, DM 2009, 'Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis', Experimental Biology and Medicine, vol. 234, no. 4, pp. 430-441. 104 93
2009	Stringer, AM, Gibson, RJ, Logan, RM, Bowen, JM, Yeoh, AS, Lawrence, J & Keefe, DM 2009, 'Irinotecan-induced mucositis is associated with changes in intestinal mucins', Cancer Chemotherapy and Pharmacology, vol. 64, no. 1, pp. 123-132. 51 46
2008	Logan, R, Stringer, AM, Bowen, J, Gibson, R, Sonis, S & Keefe, D 2008, 'Serum levels of NFκB and pro-inflammatory cytokines following administration of mucotoxic drugs', Cancer Biology and Therapy, vol. 7, no. 7, pp. 1139-1145. 105 89
2008	Logan, RM, Gibson, RJ, Bowen, JM, Stringer, AM, Sonis, ST & Keefe, DM 2008, 'Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis', Cancer Chemotherapy and Pharmacology, vol. 62, no. 1, pp. 33-41. 116 111
2008	Stringer, AM, Gibson, RJ, Logan, RM, Bowen, JM, Yeoh, AS & Keefe, DM 2008, 'Faecal microflora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats', Cancer Biology and Therapy, vol. 7, no. 12, pp. 1919-1925. 82 77

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Brigham and Women's Hospital	UNITED STATES
Cancer Council of South Australia	AUSTRALIA
Copenhagen University	DENMARK
Ersta Skondal Bracke University College	SWEDEN
Ghent University	BELGIUM
Griffith University	AUSTRALIA
Hanson Institute	AUSTRALIA
Mount Sinai Hospital	UNITED STATES
National University of Singapore	SINGAPORE
Nestle Nutrition R & D Center	UNITED STATES
Nestle Research centre	SWITZERLAND
Radboud University Nijmegen	NETHERLANDS
Radboud University Nijmegen Medical Centre	NETHERLANDS
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
University Medical Centre	NETHERLANDS
University of Adelaide	AUSTRALIA
University of Amsterdam	NETHERLANDS
University of Brescia	ITALY
University of Campinas	BRAZIL
University of Connecticut	UNITED STATES
University of Gothenburg	SWEDEN
University of Groningen	NETHERLANDS
University of Rochester	UNITED STATES
University of Rochester Medical Center	UNITED STATES
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Editorial Board Member Analytical and Cellular Pathology	2018
Editorial Board Member World Journal of Clinical Oncology	2018
Member Australian Society for Medical Research (ASMR)	2018
Member Multinational Association of Supportive Care in Cancer (MASCC)	2018
Member Society of Experimental Biology and Medicine (SEBM)	2018
Member Mucositis Study Group (MASCC)	2018
Invited Chair (multiple sessions) Multinational Association of Supportive Care in Cancer (MASCC)	2017
Invited Presentation University of Gothenburg, Sweden	2017
Member Multinational Association of Supportive Care in Cancer (MASCC)	2017
Member, Committee Australian Society for Medical Research (ASMR)	2017
Invited Chair New perspectives on Mucositis research workshop, Copenhagen, Denmark	2015
Invited speaker New perspectives on Mucositis research workshop, Copenhagen, Denmark	2015
Invited speaker, ISOO session Multinational Association of Supportive Care in Cancer (MASCC), Copenhagen, Denmark	2015
Basic Science member Multinational Association of Supportive Care in Cancer Awards Committee	2014
Invited Presentation University of Ghent, Belgium	2014
Invited Presentation Academisch Centrum Tandheelkunde Amsterdam (ACTA) Amsterdam, Netherlands	2014
Member, State Committee Australian Society for Medical Research (ASMR)	2014
Treasurer, State Committee Australian Society for Medical Research (ASMR)	2013
Treasurer, State Committee Australian Society for Medical Research (ASMR)	2012
Gala Dinner Convenor Australian Society for Medical Research (ASMR)	2011
Training Fellowship National Health and Medical Research Council (NHMRC)	2011
Gala Dinner Co-convenor Australian Society for Medical Research (ASMR)	2010
Invited Presentation Discipline of Anatomical Sciences, University of Adelaide	2008
Invited Presentations University Medical Center Groningen (UMCG), Netherlands	2008

Teaching & student supervision

Highlights

Biosciences

Supervision of Honours and Higher Degree Research students

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Targeting Vitamin D Metabolism in Bone to Improve Bone Strength	Current
Chemotherapy-induced mucositis: the role of mucin secresion and regulation, and the enteric nervous system	Completed
Further characterisation of the rotenone model: investigation of TH and BDNF in the brain and periphery, and associated gastrointestinal dysfunction	Completed
The effects of elsiglutide on chemotherapy-induced mucositis	Completed
The intestinal microbiome and the stressed gastrointestinal mucosa	Completed

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Dr Andrea Stringer

About me

About me

School of Pharmacy and Medical Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Highlights

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Editorial Board Member

Editorial Board Member

Member

Member

Member

Member

Invited Chair (multiple sessions)

Invited Presentation

Member

Member, Committee

Invited Chair

Invited speaker

Invited speaker, ISOO session

Basic Science member

Invited Presentation

Invited Presentation

Member, State Committee

Treasurer, State Committee

Treasurer, State Committee

Gala Dinner Convenor

Training Fellowship

Gala Dinner Co-convenor

Invited Presentation

Invited Presentations

Teaching & student supervision

Highlights

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

Gallery