Dr Anna Brown

Adjunct Associate Professor Centre for Cancer Biology

City West Campus (HB8-29)
tel +61 8 830 27660

email Anna.Brown2@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Clinical Sciences
Cardiovascular Medicine and Haematology
Oncology and Carcinogenesis
Biochemistry and Cell Biology
Biological Sciences

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Hiwase, D, Hahn, C, Tran, ENH, Chhetri, R, Wang, P, Kumar, S, Brown, A, Scott, H, Kok, CH & Shah, MV and 41 other authors 2023, 'TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype', Blood, vol. 141, no. 9, pp. 1087-1091. Open access
2023	Samaraweera, SE, Geukens, T, Casolari, DA, Nguyen, T, Sun, C, Bailey, S, Moore, S, Feng, J, Schreiber, AW, Parker, WT, Brown, AL, Butcher, C, Bardy, PG, Osborn, M, Scott, HS, Talaulikar, D, Grove, CS, Hahn, CN, D'Andrea, RJ & Ross, DM 2023, 'Novel modes of MPL activation in triple-negative myeloproliferative neoplasms', Pathology, vol. 55, no. 1, pp. 77-85.
2022	Bassal, MA, Samaraweera, SE, Lim, K, Bernard, BA, Bailey, S, Toubia, J, Nguyen, T, Maung, KZY, Casolari, DA, Iarossi, DG, Powell, J, Pitson, S, Brown, AL, Robinson, N, Ross, DM, Gonda, TJ & D'Andrea, RJ and 10 other authors 2022, 'Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia', Nature Communications, vol. 13, article no. 2614, pp. 1-12. Open access 3 5 8
2022	Brown, AL 2022, 'And the germline beat (AML) goes on', Blood, vol. 139, no. 8, pp. 1126-1128. Open access
2022	Drazer, MW, Homan, CC, Yu, K, de Andrade Silva, M, Feng, J, King-Smith, SL, Lawrence, DM, Schreiber, AW, Hahn, CN, Scott, HS, Brown, AL & Godley, LA and 10 other authors & 1 consortia 2022, 'Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.', Blood Advances, vol. 6, no. 15, pp. 4357-4359. Open access 2 1 1
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 8 5
2022	Tawana, K, Brown, AL & Churpek, JE 2022, 'Integrating germline variant assessment into routine clinical practice for myelodysplastic syndrome and acute myeloid leukaemia: current strategies and challenges', British Journal of Haematology, vol. 196, no. 6, pp. 1293-1310. 16 13 2
2021	Homan, CC, Venugopal, P, Arts, P, Shahrin, NH, Feurstein, S, Rawlings, L, Lawrence, DM, Andrews, J, King-Smith, SL, Harvey, NL, Brown, AL, Scott, HS & Hahn, CN 2021, 'GATA2 deficiency syndrome: a decade of discovery', Human Mutation, vol. 42, no. 11, pp. 1399-1421. Open access 6 6 11
2021	Samaraweera, SE, Wang, PP, Li, KL, Casolari, DA, Feng, J, Maung, KZY, Scott, HS, Schreiber, AW, Brown, AL, Ross, DM, Gonda, TJ, Hahn, CN & D'Andrea, RJ and 13 other authors 2021, 'Childhood acute myeloid leukemia shows a high level of germline predisposition', Blood, vol. 138, no. 22, pp. 2293-2298. 4 4 41
2021	Singhal, D, Hahn, CN, Feurstein, S, Wee, LYA, Eshraghi, L, Schreiber, AW, Feng, J, Brown, AL, D'Andrea, RJ, Scott, HS & Hiwase, DK and 14 other authors 2021, 'Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer', Leukemia, vol. 35, pp. 3245-3256. 23 20 12
2020	Brown, AL & Hiwase, DK 2020, 'What's germane in the germline? Finding clinically relevant germline variants in myeloid neoplasms from tumor only screening', Leukemia Research, vol. 96, article no. 106431, pp. 1-3. 3 2
2020	Brown, AL, Arts, P, Babic, M, Dobbins, J, Feng, J, Ha, T, Homan, CC, King-Smith, SL, Li, X-C, Brautigan, P, Butcher, C, D'Andrea, RJ, Hahn, CN & Scott, HS and 46 other authors 2020, 'RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML', Blood Advances, vol. 4, no. 6, pp. pp. 1131-1144. Open access 58 55 3
2020	Brown, AL, Hahn, C, Hiwase, D, Godley, LA & Scott, HS 2020, 'Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis', Leukemia and Lymphoma, vol. 61, no. 1, pp. 246-247. 2 2 4
2020	Brown, AL, Hahn, CN & Scott, HS 2020, 'Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)', Blood, vol. 136, pp. 24-35. Open access 43 37 3
2020	Corboy, G, Othman, J, Lee, L, Wei, A, Ivey, A, Blombery, P, Agarwal, R, Fong, C, Brown, A, Scott, H, Grove, C, Louw, A, Enjeti, A, Iland, H, Paul, C, Bohlander, S, Kakadia, P, Horan, M & Stevenson, W 2020, 'Laboratory quality assessment of candidate gene panel testing for acute myeloid leukaemia: a joint ALLG / RCPAQAP initiative', Pathology, vol. 53, no. 4, pp. 487-492.
2020	Fox, LC, Tan, M, Brown, AL, Arts, P, Thompson, E, Ryland, GL, Lickiss, J, Scott, HS, Poplawski, NK, Phillips, K, Came, NA, James, P, Ting, SB, Ritchie, DS, Szer, J, Hahn, CN, Schwarer, A & Blombery, P 2020, 'A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability', British Journal of Haematology, vol. 190, no. 5, pp. 297-301. Open access 11 10
2020	Venugopal, P, Gagliardi, L, Forsyth, C, Feng, J, Phillips, K, Babic, M, Poplawski, NK, Rienhoff, HY, Schreiber, AW, Hahn, CN, Brown, AL & Scott, HS 2020, 'Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss', BMC Medical Genetics, vol. 21, no. 1, article no. 35, pp. 1-5. Open access 2 2 1
2019	Cheah, JJ, Brown, AL, Schreiber, AW, Feng, J, Babic, M, Moore, S, Young, C-C, Fine, M, Phillips, K, Guandalini, M, Wilson, P, Poplawski, N, Hahn, CN & Scott, HS 2019, 'A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia', Haematologica: The Hematology Journal, vol. 104, no. 7, pp. e318-e321. Open access 13 12 1
2019	Iacobucci, I, Wen, J, Meggendorfer, M, Choi, JK, Lewis, ID, D'Andrea, RJ, Brown, AL, Scott, HS, Hahn, CN & Mullighan, CG 2019, 'Genomic subtyping and therapeutic targeting of acute erythroleukemia', Nature Genetics, vol. 51, no. 4, pp. 694-704. Open access 71 69 86
2019	Luo, X, Feurstein, S, Mohan, S, Porter, CC, Brown, AL & Godley, LA 2019, 'ClinGen myeloid malignancy variant curation expert panel recommendations for germline RUNX1 variants', Blood Advances, vol. 3, no. 20, pp. 2962-2979. Open access 72 66 2
2018	Branford, S, Wang, P, Yeung, DT, Thomson, D, Wadham, C, Shahrin, NH, Marum, JE, Nataren, N, Parker, WT, Shanmuganathan, N, Donaldson, Z, Altamura, H, Georgievski, J, Brown, A, Hahn, C, White, DL, Scott, HS, Schreiber, AW & Hughes, TP and 18 other authors 2018, 'Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease', Blood, vol. 132, no. 9, pp. 948-961. Open access 105 105 8
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 39 37 4
2018	Maung, KZY, Leo, PJ, Bassal, M, Casolari, DA, Bray, SC, Singhal, D, Samaraweera, SE, Nguyen, T, Cildir, G, Tergaonkar, V, Lewis, I, Brown, AL, D'Andrea, RJ & Gonda, TJ and 11 other authors 2018, 'Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia', Blood Cancer Journal, vol. 8, no. 6, article no. 50, pp. 1-5. Open access 13 13 3
2017	Brown, AL, Churpek, JE, Malcovati, L, Döhner, H & Godley, LA 2017, 'Recognition of familial myeloid neoplasia in adults', Seminars in Hematology, vol. 54, no. 2, pp. 60-68. 29 25 2
2017	Cheah, JJ, Hahn, CN, Hiwase, DK, Scott, HS & Brown, AL 2017, 'Myeloid neoplasms with germline DDX41 mutation', International Journal of Hematology, vol. 106, no. 2, pp. 163-174. 60 55 2
2016	Lewinsohn, M, Brown, AL, Weinel, LM, Phung, C, Chong, C-E, D'Andrea, RJ & Scott, HS and 23 other authors 2016, 'Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset, and lymphoid malignancies', Blood, vol. 127, no. 8, pp. 1017-1023. Open access 145 130 8
2016	Li, S, Garrett-Bakelman, FE, Chung, SS, Sanders, MA, Brown, AL, D'Andrea, RJ & Mason, CE and 26 other authors 2016, 'Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia', Nature Medicine, vol. 22, no. 7, pp. 792-802. Open access 229 225 61
2016	Lynch, JR, Yi, H, Casolari, DA, Voli, F, Gonzales-Aloy, E, Fung, TK, Liu, B, Brown, AL, Liu, T, Haber, M, Norris, MD, Lewis, ID, So, CWE, D'Andrea, RJD & Wang, JY 2016, 'Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia', Leukemia, vol. 30, pp. 1745-1748. Open access 6 5 7
2016	Shahrin, NH, Diakiw, S, Dent, LA, Brown, AL & D'Andrea, RJ 2016, 'Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor', Blood, vol. 128, no. 1, pp. 55-59. Open access 23 24 1
2015	Hahn, C, Ross, D, Feng, J, Beligaswatte, A, Hiwase, D, Parker, W, Ho, M, Zawitkowski, M, Ambler, K, Cheetham, G, Lee, Y, Babic, M, Butcher, C, Engler, G, Brown, A, D'Andrea, R, Lewis, I, Schreiber, A, To, L & Scott, H 2015, 'A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone', Leukemia, vol. 29, no. 10, pp. 2101-2104. Open access 14 23
2014	Li, S, Garrett-Bakelman, F, Perl, AE, Luger, SM, Zhang, C, To, BL, Lewis, ID, Brown, AL, D'Andrea, RJ, Ross, EM, Levine, R, Carroll, M, Melnick, A & Mason, C 2014, 'Dynamic evolution of clonal epialleles revealed by methclone', Genome Biology, vol. 15, no. 9, article no. 472. Open access 46 51 9
2013	Diakiw, S, D'Andrea, RJ & Brown, AL 2013, 'The double life of KLF5: opposing roles in regulation of gene-expression, cellular function, and transformation', IUBMB Life, vol. 65, no. 12, pp. 999-1011. Open access 40 36 1
2013	Diakiw, SM, Perugini, M, Kok, CH, Engler, GA, Cummings, N, To, LB, Wei, AH, Lewis, ID, Brown, AL & D'Andrea, RJ 2013, 'Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival', British Journal of Haematology, vol. 161, no. 6, pp. 884-888. Open access 15 15 1
2013	Kok, CH, Brown, AL, Perugini, M, Iarossi, DG, Lewis, ID & D'Andrea, RJ 2013, 'The preferential occurrence of FLT3-TKD mutations in inv(16) AML and impact on survival outcome: a combined analysis of 1053 core-binding factor AML patients', British Journal of Haematology, vol. 160, no. 4, pp. 557-559. Open access 9 10
2013	Li, S, Garrett-Bakelman, FE, Akalin, A, Zumbo, P, Levine, R, To, BL, Lewis, I, Brown, AL, D'Andrea, RJ, Melnick, A & Mason, CE 2013, 'An optimized algorithm for detecting and annotating regional differential methylation', BMC Bioinformatics, vol. 14, no. S5, article no. s10, pp. 1-9. Open access 86 82 7
2013	Perugini, M, Iarossi, D, Kok, C, Cummings, N, Diakiw, S, Brown, A, Danner, S, Bardy, P, Bik, TL, Wei, A, Lewis, I & D'Andrea, R 2013, 'GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations', Leukemia, vol. 27, pp. 1588-1592. Open access 19 15
2012	Brown, AL, Salerno, DG, Sadras, T, Engler, GA, Kok, CH, Wilkinson, CR, Samaraweera, SE, Sadlon, TJ, Perugini, M, Lewis, ID, Gonda, TJ & D'Andrea, RJ 2012, 'The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation', Differentiation, vol. 83, no. 1, pp. 47-59. Open access 16 15 3
2012	Diakiw, SM, Kok, CH, Bik, TL, Lewis, ID, Brown, AL & D'Andrea, RJ 2012, 'The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia', Leukemia Research, vol. 36, no. 1, pp. 110-116. Open access 22 21
2012	White, DL, Brown, AL, D'Andrea, RJ & Rice, AM 2012, 'Unraveling the 'Known Unknowns': lessons and Reflections from the New Directions in Leukemia Research 2012 Conference', Cancer Research, vol. 72, no. 17, pp. 4300-4303. Open access 1
2011	Hahn, CN, Chong, C-E, Carmichael, CL, Wilkins, EJ, Brautigan, PJ, Brown, AL, D'Andrea, RJ & Scott, HS and 20 other authors 2011, 'Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia', Nature Genetics, vol. 43, no. 10, pp. 1012-1019. Open access 445 404
2010	Kok, C, Brown, A, Ekert, P & D'Andrea, R 2010, 'Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML', Leukemia, vol. 24, no. 6, pp. 1239-1243. Open access 13 12
2010	Perugini, M, Brown, AL, Salerno, DG, Booker, GW, Stojkoski, C, Hercus, TR, Lopez, AF, Hibbs, ML, Gonda, TJ & D'Andrea, RJ 2010, 'Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit', Blood, vol. 115, no. 16, pp. 3346-3353. Open access 50 46
2009	Perugini, M, Kok, C, Brown, A, Wilkinson, C, Salerno, D, Young, S, Lewis, I, Gonda, T & D'Andrea, R 2009, 'Repression of Gadd45a by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation', Leukemia, vol. 23, no. 4, pp. 729-738. Open access 18 16
2009	Powell, JA, Thomas, D, Barry, EF, Kok, CH, McClure, BJ, Tsykin, A, To, LB, Brown, A, Lewis, ID, Herbert, K, Goodall, GJ, Speed, TP, Asou, N, Jacob, B, Osato, M, Haylock, DN, Nilsson, SK, D'Andrea, RJ, Lopez, AF & Guthridge, MA 2009, 'Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML', Blood, vol. 114, no. 23, pp. 4859-4870. 52 49

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Addenbrooke's Hospital	UNITED KINGDOM
Alfred Health	AUSTRALIA
Auckland City Hospital	NEW ZEALAND
Australasian Leukaemia and Lymphoma Group	AUSTRALIA
Baylor College of Medicine	UNITED STATES
Canberra Hospital	AUSTRALIA
Cancer Institute NSW	AUSTRALIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Cornell University	UNITED STATES
Eastern Health	AUSTRALIA
Emory University	UNITED STATES
Erasmus University Rotterdam	NETHERLANDS
Federal University of Alagoas	BRAZIL
Feil Family Brain and Mind Research Institute	UNITED STATES
Flinders University	AUSTRALIA
Harvard University	UNITED STATES
Imago Biosciences	UNITED STATES
Institute of Medical and Veterinary Science	AUSTRALIA
Jarrett St Specialist Centre	AUSTRALIA
King's College London	UNITED KINGDOM
Kumamoto University	JAPAN
Lady Cilento Children's Hospital	AUSTRALIA
Ludwig Institute for Cancer Research	AUSTRALIA
Mayo Clinic	UNITED STATES
Memorial Sloan Kettering Cancer Centre	UNITED STATES
Memorial Sloan-Kettering Cancer Center	UNITED STATES
MLL Münchner Leukämielabor GmbH	GERMANY
Monash University	AUSTRALIA
Murdoch Childrens Research Institute	AUSTRALIA
National Institutes of Health	UNITED STATES
National University of Singapore	SINGAPORE
Peter MacCallum Cancer Centre	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal College of Pathologists of Australasia	AUSTRALIA
Royal Melbourne Hospital	AUSTRALIA
Royal North Shore Hospital	AUSTRALIA
Royal Prince Alfred Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Sir Charles Gardiner Hospital	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St. Jude Children's Research Hospital	UNITED STATES
Stanford University	UNITED STATES
Ulm University	GERMANY
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Chicago	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Pavia	ITALY
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Wisconsin-Madison	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Weill Cornell Medical College	UNITED STATES
Women's and Children's Health Network	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
109455 - Examining the impact of environmental stressors and mutant microenvironment on disease development in models of inherited predisposition to haematological malignancies	Current
Discovery of novel germline genes in familial haematological malignancies	Completed
Metabolic profiling of adult acute myeloid leukaemia (AML)	Completed

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Dr Anna Brown

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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