Dr Anna Brown

Adjunct Senior Research Fellow Centre for Cancer Biology

City West Campus (HB8-29)
tel +61 8 830 27660

email Anna.Brown2@unisa.edu.au

Research Degree Supervisor

Research

Research themes

Cancer
Healthy futures

Research focus

Cardiovascular Medicine and Haematology
Clinical Sciences
Oncology and Carcinogenesis
Biochemistry and Cell Biology
Biological Sciences

Research

Outputs

Research since 2008 is shown below. To see earlier years visit Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2020	Brown, AL, Arts, P, Babic, M, Dobbins, J, Feng, J, Ha, T, Homan, CC, King-Smith, SL, Li, X-C, Brautigan, P, Butcher, C, D'Andrea, RJ, Hahn, CN & Scott, HS and 46 other authors 2020, 'RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML', Blood Advances, vol. 4, no. 6, pp. pp. 1131-1144. Open access 3 2
2020	Fox, LC, Tan, M, Brown, AL, Arts, P, Thompson, E, Ryland, GL, Lickiss, J, Scott, HS, Poplawski, NK, Phillips, K, Came, NA, James, P, Ting, SB, Ritchie, DS, Szer, J, Hahn, CN, Schwarer, A & Blombery, P 2020, 'A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability', British Journal of Haematology, online, pp. 1-4. Open access 3 2
2020	Hahn, CN, Scott, HS & Brown, AL 2020, 'Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)', Blood, online. 4 3 2
2019	Cheah, JJ, Brown, AL, Schreiber, AW, Feng, J, Babic, M, Moore, S, Young, C-C, Fine, M, Phillips, K, Guandalini, M, Wilson, P, Poplawski, N, Hahn, CN & Scott, HS 2019, 'A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia', Haematologica: The Hematology Journal, vol. 104, no. 7, pp. e318-e321. Open access 3 1 1
2019	Iacobucci, I, Wen, J, Meggendorfer, M, Choi, JK, Lewis, ID, D'Andrea, RJ, Brown, AL, Scott, HS, Hahn, CN & Mullighan, CG 2019, 'Genomic subtyping and therapeutic targeting of acute erythroleukemia', Nature Genetics, vol. 51, no. 4, pp. 694-704. Open access 18 19 88
2019	Luo, X, Feurstein, S, Mohan, S, Porter, CC, Brown, AL & Godley, LA 2019, 'ClinGen myeloid malignancy variant curation expert panel recommendations for germline RUNX1 variants', Blood Advances, vol. 3, no. 20, pp. 2962-2979. Open access 9 9 2
2018	Branford, S, Wang, P, Yeung, DT, Thomson, D, Wadham, C, Shahrin, NH, Marum, JE, Nataren, N, Parker, WT, Shanmuganathan, N, Donaldson, Z, Altamura, H, Georgievski, J, Brown, A, Hahn, C, White, DL, Scott, HS, Schreiber, AW & Hughes, TP and 18 other authors 2018, 'Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease', Blood, vol. 132, no. 9, pp. 948-961. 37 37 8
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 20 19 4
2018	Maung, KZY, Leo, PJ, Bassal, M, Casolari, DA, Bray, SC, Singhal, D, Samaraweera, SE, Nguyen, T, Cildir, G, Tergaonkar, V, Lewis, I, Brown, AL, D'Andrea, RJ & Gonda, TJ and 11 other authors 2018, 'Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia', Blood Cancer Journal, vol. 8, no. 6, article no. 50, pp. 1-5. Open access 7 6 3
2017	Brown, AL, Churpek, JE, Malcovati, L, Döhner, H & Godley, LA 2017, 'Recognition of familial myeloid neoplasia in adults', Seminars in Hematology, vol. 54, no. 2, pp. 60-68. 17 18 2
2017	Cheah, JJ, Hahn, CN, Hiwase, DK, Scott, HS & Brown, AL 2017, 'Myeloid neoplasms with germline DDX41 mutation', International Journal of Hematology, vol. 106, no. 2, pp. 163-174. 21 20 2
2016	Li, S, Garrett-Bakelman, FE, Chung, SS, Sanders, MA, Brown, AL, D'Andrea, RJ & Mason, CE and 26 other authors 2016, 'Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia', Nature Medicine, vol. 22, no. 7, pp. 792-802. Open access 137 135 62
2016	Lynch, JR, Yi, H, Casolari, DA, Voli, F, Gonzales-Aloy, E, Fung, TK, Liu, B, Brown, AL, Liu, T, Haber, M, Norris, MD, Lewis, ID, So, CWE, D'Andrea, RJD & Wang, JY 2016, 'Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia', Leukemia, vol. 30, pp. 1745-1748. Open access 6 5 7
2016	Shahrin, NH, Diakiw, S, Dent, LA, Brown, AL & D'Andrea, RJ 2016, 'Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor', Blood, vol. 128, no. 1, pp. 55-59. Open access 15 13 1
2015	Hahn, C, Ross, D, Feng, J, Beligaswatte, A, Hiwase, D, Parker, W, Ho, M, Zawitkowski, M, Ambler, K, Cheetham, G, Lee, Y, Babic, M, Butcher, C, Engler, G, Brown, A, D'Andrea, R, Lewis, I, Schreiber, A, To, L & Scott, H 2015, 'A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone', Leukemia, vol. 29, no. 10, pp. 2101-2104. Open access 14 19
2015	Lewinsohn, M, Brown, AL, Weinel, LM, Phung, C, Chong, C-E, D'Andrea, RJ & Scott, HS and 23 other authors 2015, 'Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset, and lymphoid malignancies', Blood, vol. 127, no. 8, pp. 1017-1023. Open access 81 71 8
2014	Li, S, Garrett-Bakelman, F, Perl, AE, Luger, SM, Zhang, C, To, BL, Lewis, ID, Brown, AL, D'Andrea, RJ, Ross, EM, Levine, R, Carroll, M, Melnick, A & Mason, C 2014, 'Dynamic evolution of clonal epialleles revealed by methclone', Genome Biology, vol. 15, no. 9, article no. 472. Open access 26 32 6
2013	Diakiw, S, D'Andrea, RJ & Brown, AL 2013, 'The double life of KLF5: opposing roles in regulation of gene-expression, cellular function, and transformation', IUBMB Life, vol. 65, no. 12, pp. 999-1011. Open access 23 21 1
2013	Diakiw, SM, Perugini, M, Kok, CH, Engler, GA, Cummings, N, To, LB, Wei, AH, Lewis, ID, Brown, AL & D'Andrea, RJ 2013, 'Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival', British Journal of Haematology, vol. 161, no. 6, pp. 884-888. Open access 9 10 1
2013	Kok, CH, Brown, AL, Perugini, M, Iarossi, DG, Lewis, ID & D'Andrea, RJ 2013, 'The preferential occurrence of FLT3-TKD mutations in inv(16) AML and impact on survival outcome: a combined analysis of 1053 core-binding factor AML patients', British Journal of Haematology, vol. 160, no. 4, pp. 557-559. 7 8
2013	Li, S, Garrett-Bakelman, FE, Akalin, A, Zumbo, P, Levine, R, To, BL, Lewis, I, Brown, AL, D'Andrea, RJ, Melnick, A & Mason, CE 2013, 'An optimized algorithm for detecting and annotating regional differential methylation', BMC Bioinformatics, vol. 14, no. S5, article no. s10, pp. 1-9. Open access 57 57 7
2013	Perugini, M, Iarossi, D, Kok, C, Cummings, N, Diakiw, S, Brown, A, Danner, S, Bardy, P, Bik, TL, Wei, A, Lewis, I & D'Andrea, R 2013, 'GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations', Leukemia, vol. 27, pp. 1588-1592. Open access 14 13
2012	Brown, AL, Salerno, DG, Sadras, T, Engler, GA, Kok, CH, Wilkinson, CR, Samaraweera, SE, Sadlon, TJ, Perugini, M, Lewis, ID, Gonda, TJ & D'Andrea, RJ 2012, 'The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation', Differentiation, vol. 83, no. 1, pp. 47-59. Open access 13 12
2012	Diakiw, SM, Kok, CH, Bik, TL, Lewis, ID, Brown, AL & D'Andrea, RJ 2012, 'The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia', Leukemia Research, vol. 36, no. 1, pp. 110-116. Open access 17 17
2012	White, DL, Brown, AL, D'Andrea, RJ & Rice, AM 2012, 'Unraveling the 'Known Unknowns': lessons and Reflections from the New Directions in Leukemia Research 2012 Conference', Cancer Research, vol. 72, no. 17, pp. 4300-4303. Open access 1
2011	Hahn, CN, Chong, C-E, Carmichael, CL, Wilkins, EJ, Brautigan, PJ, Brown, AL, D'Andrea, RJ & Scott, HS and 20 other authors 2011, 'Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia', Nature Genetics, vol. 43, no. 10, pp. 1012-1019. Open access 349 323 12
2010	Kok, C, Brown, A, Ekert, P & D'Andrea, R 2010, 'Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML', Leukemia, vol. 24, no. 6, pp. 1239-1243. 11 10
2010	Perugini, M, Brown, AL, Salerno, DG, Booker, GW, Stojkoski, C, Hercus, TR, Lopez, AF, Hibbs, ML, Gonda, TJ & D'Andrea, RJ 2010, 'Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit', Blood, vol. 115, no. 16, pp. 3346-3353. Open access 39 37
2009	Perugini, M, Kok, C, Brown, A, Wilkinson, C, Salerno, D, Young, S, Lewis, I, Gonda, T & D'Andrea, R 2009, 'Repression of Gadd45a by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation', Leukemia, vol. 23, no. 4, pp. 729-738. 17 16
2009	Powell, JA, Thomas, D, Barry, EF, Kok, CH, McClure, BJ, Tsykin, A, To, LB, Brown, A, Lewis, ID, Herbert, K, Goodall, GJ, Speed, TP, Asou, N, Jacob, B, Osato, M, Haylock, DN, Nilsson, SK, D'Andrea, RJ, Lopez, AF & Guthridge, MA 2009, 'Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML', Blood, vol. 114, no. 23, pp. 4859-4870. 45 43

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Baylor College of Medicine	UNITED STATES
Cancer Institute NSW	AUSTRALIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Cornell University	UNITED STATES
Eastern Health	AUSTRALIA
Emory University	UNITED STATES
Erasmus University Rotterdam	NETHERLANDS
Feil Family Brain and Mind Research Institute	UNITED STATES
Flinders University	AUSTRALIA
Institute of Medical and Veterinary Science	AUSTRALIA
King's College London	UNITED KINGDOM
Kumamoto University	JAPAN
Lady Cilento Children's Hospital	AUSTRALIA
Ludwig Institute for Cancer Research	AUSTRALIA
Memorial Sloan Kettering Cancer Centre	UNITED STATES
Memorial Sloan-Kettering Cancer Center	UNITED STATES
MLL Münchner Leukämielabor GmbH	GERMANY
Monash University	AUSTRALIA
Murdoch Childrens Research Institute	AUSTRALIA
National University of Singapore	SINGAPORE
Peter MacCallum Cancer Centre	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Melbourne Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
St. Jude Children's Research Hospital	UNITED STATES
Ulm University	GERMANY
University of Adelaide	AUSTRALIA
University of Chicago	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Pavia	ITALY
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Weill Cornell Medical College	UNITED STATES
Women's and Children's Health Network	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Discovery of novel germline genes in familial haematological malignancies	Current
Metabolic profiling of adult acute myeloid leukaemia (AML)	Completed

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Dr Anna Brown

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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