Dr Anwar Mulugeta

Research Associate: Genetic Epidemiology / Statistical Genetics / Bioinformatics UniSA Clinical & Health Sciences

email AnwarMulugeta.Gebremichael@unisa.edu.au

Alternative contact

Research Degree Supervisor

About me

MR, PheWAS, GWAS, Dementia, Machine learning

Dr. Anwar Mulugeta is a Research Associate at the Nutritional and Genetic Epidemiology Research Group. With over five years of experience as a steering committee member at the Australian Centre for Precision Health, he brings a wealth of expertise to his role. Dr. Mulugeta holds a Ph.D. in Genetic Epidemiology (awarded in 2020), an M.Pharm in Medical Pharmacology (completed in 2011), and a B.Pharm in Pharmacy (completed in 2008). He is also affiliated with the Department of Pharmacology and Clinical Pharmacy at Addis Ababa University (AAU), Ethiopia. Prior to this, he served as a Clinical Trial Coordinator for a collaborative project between AAU and Massachusetts General Hospital. Dr. Mulugeta's primary research focus lies in... Read more

UniSA Clinical & Health Sciences

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Research

Research focus

Public Health and Health Services
Clinical Sciences
Medical and Health Sciences
Biochemistry and Cell Biology
Neurosciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2025	Yeshaw, Y, Madakkatel, I, Mulugeta, A, Lumsden, A & Hypponen, E 2025, 'Machine learning to discover factors predicting volume of white matter hyperintensities: insights from the UK Biobank', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 17, no. 1, article no. e70090, pp. 1-12. Open access
2024	Kassaw, NA, Zhou, A, Mulugeta, A, Lee, SH, Burgess, S & Hyppönen, E 2024, 'Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study', International Journal of Epidemiology, vol. 53, no. 2, pp. 1-8. Open access 7 6 54
2024	Madakkatel, I, Lumsden, AL, Mulugeta, A, Maenpaa, J, Oehler, MK & Hyppönen, E 2024, 'Large-scale analysis to identify risk factors for ovarian cancer', International Journal of Gynecological Cancer, online, pp. 1-9. Open access 1 1 170
2024	Mulugeta, A, Lumsden, A, Madakkatel, I, Stacey, D, Lee, SH, Mäenpää, J, Oehler, M & Hypponen, E 2024, 'Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers', Cancer Medicine, vol. 13, no. 4, article no. e7051, pp. 1-13. Open access 2
2024	Yalew, M, Mulugeta, A, Lumsden, AL, Madakkatel, I, Lee, SH, Oehler, MK, Maenpaa, J & Hyppönen, E 2024, 'Circulating phylloquinone and the risk of four female-specific cancers: a mendelian randomization study', Nutrients, vol. 16, no. 21, article no. 3680, pp. 1-9. Open access
2024	Yeshaw, Y, Madakkatel, MI, Mulugeta, A, Lumsden, A & Hyppönen, E 2024, 'Uncovering predictors of low hippocampal volume: evidence from a large-scale machine-learning-based study in the UK biobank', Neuroepidemiology, vol. 58, pp. 369-382. Open access
2023	Ahmed, M, Mäkinen, VP, Lumsden, A, Boyle, T, Mulugeta, A, Lee, SH, Olver, I & Hyppönen, E 2023, 'Metabolic profile predicts incident cancer: a large-scale population study in the UK Biobank', Metabolism: Clinical and Experimental, vol. 138, article no. 155342. Open access 6 6 4
2023	Lumsden, AL, Mulugeta, A, Makinen, V-P & Hypponen, E 2023, 'Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition', Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, vol. 25, no. 1, pp. 121-131. Open access 6 6 127
2023	Madakkatel, I, Lumsden, AL, Mulugeta, A, Olver, I & Hypponen, E 2023, 'Hypothesis-free discovery of novel cancer predictors using machine learning', European Journal of Clinical Investigation, vol. 53, no. 10, article no. e14037, pp. 1-13. Open access 4 4 39
2023	Mulugeta, A, Suppiah, V & Hyppönen, E 2023, 'Schizophrenia and co-morbidity risk: evidence from a data driven phenomewide association study', Journal of Psychiatric Research, vol. 162, pp. 1-10. Open access 6 6
2023	Pham, K, Mulugeta, A, Lumsden, A & Hyppӧnen, E 2023, 'Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank', British Journal of Clinical Pharmacology, vol. 89, no. 10, pp. 2992-3004. Open access 2 2 97
2022	Ahmed, M, Makinen, V-P, Mulugeta, A, Shin, J, Boyle, T, Hypponen, E & Lee, SH 2022, 'Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology', Communications Biology, vol. 5, no. 1, article no. 614, pp. 1-14. Open access 7 5 5
2022	Erku, D, Mersha, AG, Ali, EE, Gebretekle, GB, Wubishet, BL, Kassie, GM, Gebremichael, A, Mekonnen, AB, Eshetie, TC & Scuffham, P 2022, 'A systematic review of scope and quality of health economic evaluations conducted in Ethiopia', Health Policy and Planning, vol. 37, no. 4, pp. 514-522. Open access 4 3 5
2022	Lumsden, AL, Mulugeta, A & Hyppönen, E 2022, 'Milk consumption and risk of twelve cancers: a large-scale observational and Mendelian randomisation study', Clinical Nutrition, vol. 42, no. 1, pp. 1-8. Open access 18 15 23
2022	Mulugeta, A, Eshetie, TC, Kassie, GM, Erku, D, Mekonnen, A, Lumsden, A & Hypponen, E 2022, 'Association between metabolically different adiposity subtypes and osteoarthritis: a Mendelian Randomization Study', Arthritis Care and Research, vol. 75, no. 4, pp. 885-892. Open access 7 5 3
2022	Mulugeta, A, Hypponen, E, Ala-Korpela, M & Makinen, V-P 2022, 'Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank', Scientific Reports, vol. 12, no. 1, article no. 8590, pp. 1-11. Open access 9 8 2
2022	Mulugeta, A, Navale, SS, Lumsden, AL, Llewellyn, DJ & Hyppönen, E 2022, 'Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank', Nutrients, vol. 14, no. 19, article no. 3907, pp. 1-13. Open access 8 8 5
2022	Navale, SS, Mulugeta, A, Zhou, A, Llewellyn, DJ & Hyppönen, E 2022, 'Vitamin D and brain health: an observational and Mendelian randomization study', American Journal of Clinical Nutrition, vol. 116, no. 2 , pp. 531-540. Open access 55 54 1331
2022	Pham, K, Mulugeta, A, Zhou, A, O'Brien, JT, Llewellyn, DJ & Hyppönen, E 2022, 'High coffee consumption, brain volume and risk of dementia and stroke', Nutritional Neuroscience, vol. 25, no. 10, pp. 2111-2122. Open access 21 25 1258
2021	Ahmed, M, Mulugeta, A, Lee, SH, Mäkinen, V-P, Boyle, T & Hyppönen, E 2021, 'Adiposity and cancer: a Mendelian randomization analysis in the UK biobank', International Journal of Obesity, vol. 45, no. 12, pp. 2657-2665. 27 22 29
2021	Challa, F, Getahun, T, Sileshi, M, Geto, Z, Kelkile, TS, Gurmessa, S, Medhin, G, Mesfin, M, Alemayehu, M, Shumet, T, Mulugeta, A, Bekele, D, Borba, CP, Oppenheim, CE, Henderson, DC, Fekadu, A, Carobene, A & Teferra, S 2021, 'Prevalence of metabolic syndrome among patients with schizophrenia in Ethiopia', BMC Psychiatry, vol. 21, no. 1, article no. 620, pp. 1-9. Open access 10 9 1
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Relationship between serum 25(Oh)d and depression: causal evidence from a bi-directional mendelian randomization study', Nutrients, vol. 13, no. 1, pp. 1-13. Open access 21 21 29
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: a Mendelian randomization study', Neurobiology of Aging, vol. 102, pp. 161-169. Open access 17 17 80
2021	Nichols, E, Abd-Allah, F, Abdoli, A, Abosetugn, AE, Mulugeta, A & Vos, T and 205 other authors 2021, 'Global mortality from dementia: application of a new method and results from the global burden of disease study 2019', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 7, no. 1, article no. e12200, pp. 1-28. Open access 109 73 19
2020	King, C, Mulugeta, A, Nabi, F, Walton, R, Zhou, A & Hyppönen, E 2020, 'Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions', EClinicalMedicine, vol. 26, article no. 100488, pp. 1-7. Open access 16 16 100
2020	Lumsden, AL, Mulugeta, A, Zhou, A & Hyppönen, E 2020, 'Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank', EBioMedicine, vol. 59, article no. 102954, pp. 1-11. Open access 167 156 82
2020	Mulugeta, A, Zhou, A, King, C & Hyppönen, E 2020, 'Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank', Molecular Psychiatry, vol. 25, no. 7, pp. 1469-1476. Open access 64 65 147
2020	Nicolopoulos, K, Gebremichael, A, Zhou, A & Hypponen, E 2020, 'Association between habitual coffee consumption and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank', Clinical Nutrition, vol. 39, no. 11, pp. 3467-3476. Open access 27 26 180
2020	Rollason, V, Mouterde, M, Daali, Y, Cizkova, M, Priehodova, E, Kulichova, I, Posova, H, Petanova, J, Mulugeta, A, Makonnen, E, Al-Habsi, A, Davidson, R, Al-Balushi, KK, Al-Thihli, K, Cerna, M, Al-Yahyaee, S, Cerny, V, Yimer, G, Poloni, ES & Desmeules, J 2020, 'Safety of the Geneva cocktail, a cytochrome P450 and P-glycoprotein phenotyping cocktail, in healthy volunteers from three different geographic origins', Drug Safety, vol. 43, no. 11, pp. 1181-1189. Open access 14 14 3
2019	Hypponen, E, Mulugeta, A, Zhou, A & Santhanakrishnan, VK 2019, 'A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank', The Lancet Digital Health, vol. 1, no. 3, pp. e116-e126. Open access 51 49 145
2019	Mulugeta, A, Zhou, A, Vimaleswaran, KS, Dickson, C & Hypponen, E 2019, 'Depression increases the genetic susceptibility to high body mass index: evidence from UK Biobank', Depression and Anxiety, vol. 36, no. 12, pp. 1154-1162. Open access 30 28 3
2019	Tyrrell, J, Gebremichael, A, Wood, AR, Zhou, A, Beaumont, RN, Tuke, MA, Jones, SE, Ruth, KS, Yaghootkar, H, Sharp, S, Thompson, WD, Ji, Y, Harrison, J, Freathy, RM, Murray, A, Weedon, MN, Lewis, C, Frayling, TM & Hyppӧnen, E and 1 consortium 2019, 'Using genetics to understand the causal influence of higher BMI on depression', International Journal of Epidemiology, vol. 48, no. 3, pp. 834-848. Open access 150 135 216
2018	Mulugeta, A, Zhou, A, Power, C & Hyppönen, E 2018, 'Obesity and depressive symptoms in mid-life: a population-based cohort study', BMC Psychiatry, vol. 18, article no. 297. Open access 45 44 16
2017	Bilal, A I, Tilahun, Z, Osman, ED, Mulugeta, A, Shekabdulahi, M & Berhe, DF 2017, 'Cosmetics use-related adverse events and determinants among Jigjiga town residents, Eastern Ethiopia', Dermatology and Therapy, vol. 7, no. 1, pp. 143-153. Open access 29 26 1
2016	Bilal, A I, Osman, ED & Mulugeta, A 2016, 'Assessment of medicines use pattern using World Health Organization's Prescribing, Patient Care and Health facility indicators in selected health facilities in eastern Ethiopia', BMC Health Services Research, vol. 16, no. 1, pp. 1-8. Open access 57 53
2016	Mulugeta, A, Medhin, G, Yimer, G, Jemal, R & Fekadu, A 2016, 'Quality of clinical trials for selected priority mental and neurological disorders in sub-Saharan Africa: a systematic review', Open Access Journal of Clinical Trials, vol. 8, pp. 43-52. Open access 2
2015	Shimels, T, Bilal, A I & Mulugeta, A 2015, 'Evaluation of Ceftriaxone utilization in internal medicine wards of general hospitals in Addis Ababa, Ethiopia: a comparative retrospective study', Journal of Pharmaceutical Policy and Practice, vol. 8, no. 1, pp. 1-8. Open access 17 5
2014	Borba, CP, Fekadu, A, Teferra, S, Bekele, D, Shibre, T, Oppenheim, CE, Biressaw, S, Mulugeta, A, Schoenfeld, DA & Henderson, DC 2014, 'A placebo-controlled trial of folate with B12 in patients with schizophrenia with residual symptoms in Ethiopia using a sequential parallel comparison design', British Journal of Medicine and Medical Research, vol. 4, no. 23, pp. 4090-4104. Open access
2014	Kiros, Y, Teklu, T, Desalegn, F, Tesfay, M, Klinkenberg, E & Mulugeta, A 2014, 'Adherence to anti-tuberculosis treatment in Tigray, Northern Ethiopia', Public Health Action, vol. 4, no. S3, pp. S31-S36. Open access 18
2012	Mulugeta, A & Chanie, T 2012, 'Cause of antiretroviral drug changes among patients on antiretroviral therapy at the art center in Dessei Regional Referral Hospital, Ethiopia', International Journal of Pharmaceutical Sciences and Research, vol. 3, no. 1, pp. 120-125. Open access 3

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Addis Ababa University	ETHIOPIA
Boston Medical Center	UNITED STATES
Boston University	UNITED STATES
Cairo University	EGYPT
Charles University in Prague	CZECH REPUBLIC
College of Medicine and Health Sciences	OMAN
Deakin University	AUSTRALIA
Debre Berhan University	ETHIOPIA
Ethiopian Public Health Institute	ETHIOPIA
Federal Police Commission Health Services Directorate	ETHIOPIA
Free University of Amsterdam	NETHERLANDS
Griffith University	AUSTRALIA
Harvard University	UNITED STATES
Horizon Health Network	CANADA
IRCCS Ospedale San Raffaele	ITALY
Jahrom University of Medical Science	IRAN
Jigjiga Health Sciences College	ETHIOPIA
Jijiga University	ETHIOPIA
Jimma University	ETHIOPIA
King's College London	UNITED KINGDOM
Massachusetts General Hospital	UNITED STATES
Mekelle Hospital	ETHIOPIA
Mekelle University	ETHIOPIA
MRC Biostatistics Unit	UNITED KINGDOM
Ohio State University	UNITED STATES
Oman Specialty Board	OMAN
Queen Mary University of London	UNITED KINGDOM
Royal Adelaide Hospital	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Sultan Qaboos University	OMAN
Sultan Qaboos University Hospital	OMAN
Tampere University	FINLAND
Tigray Regional Health Bureau	ETHIOPIA
Tigray Regional Laboratory	ETHIOPIA
Tikur Anbesa Hospital	ETHIOPIA
University College London	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Cambridge	UNITED KINGDOM
University of Exeter	UNITED KINGDOM
University of Geneva	SWITZERLAND
University of Newcastle	AUSTRALIA
University of Oulu	FINLAND
University of Queensland	AUSTRALIA
University of Reading	UNITED KINGDOM
University of South Australia	AUSTRALIA
University of Toronto	CANADA
University of Washington	UNITED STATES
Wollo University	ETHIOPIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Improving genetic prediction of ovarian cancer risk	Current
Predicting brain health and dementia: a machine learning approach	Current
Unraveling the link between blood proteins biomarkers and the risk of depression: a large-scale data-driven study	Current
Exploring the effects of serum lipids, cholesterol lowering medications and coffee on health: observational and genetic studies	Completed

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Dr Anwar Mulugeta

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About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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