Barb McClure

Research Associate Centre for Cancer Biology

City West Campus (HB10-27)
tel +61 8 830 23261

email Barb.McClure@unisa.edu.au

Research Degree Supervisor

About me

I am a mid-career researcher currently appointed as a Research Associate at The Centre for Cancer Biology in the Vascular Biology and Cell Trafficking Laboratory. I have significant experience studying haematological malignancies including genomics, molecular, receptor and cellular biology. I have published 58 peer reviewed articles receiving >1700 citations. In 2019 I was named an AMP Tomorrow Maker. My current research focus is understanding how a biomarker for poor prognosis Multiple Myeloma contributes to disease progression.

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Oncology and Carcinogenesis
Clinical Sciences
Cardiovascular Medicine and Haematology
Paediatrics and Reproductive Medicine
Antibody Development

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Kan, WL, McClure, BJ, Hahn, CN & Powell, JA 2024, 'The 10th Barossa meeting: cell signalling to cancer medicine', Cell Death and Disease, vol. 15, no. 3, article no. 230, pp. 1-3. Open access 1
2023	Eadie, LN, Rehn, JA, Breen, J, Osborn, MP, Jessop, S, Downes, CE, Heatley, SL, McClure, BJ, Yeung, DT, Revesz, T, Saxon, B & White, DL 2023, 'Case Report: Rare IKZF1 gene fusions identified in neonate with congenital KMT2A-rearranged acute lymphoblastic leukemia', Genes, vol. 14, no. 2, article no. 264, pp. 1-11. Open access 1 1 6
2023	Myo Min, KK, Ffrench, CB, McClure, BJ, Ortiz, M, Dorward, EL, Samuel, MS, Ebert, LM, Mahoney, Mỹ & Bonder, CS 2023, 'Desmoglein-2 as a cancer modulator: friend or foe?', Frontiers in Oncology, vol. 13, article no. 1327478 , pp. 1-15. Open access 1 2 2
2023	Thomson, AJ, Rehn, JA, Heatley, SL, Eadie, LN, Page, EC, Schutz, C, Mcclure, BJ, Sutton, R, Dalla-Pozza, L, Moore, AS, Greenwood, M, Kotecha, RS, Fong, CY, Yong, AS, Yeung, DT, Breen, J & White, DL 2023, 'Reproducible Bioinformatics Analysis Workflows for Detecting IGH Gene Fusions in B-Cell Acute Lymphoblastic Leukaemia Patients', Cancers, vol. 15, no. 19, article no. 4731, pp. 1-13. Open access 4 5
2022	Downes, CE, McClure, BJ, McDougal, DP, Heatley, SL, Bruning, JB, Thomas, D, Yeung, DT & White, DL 2022, 'JAK2 alterations in acute lymphoblastic leukemia: molecular insights for superior precision medicine strategies', Frontiers in Cell and Developmental Biology, vol. 10, article no. 942053, pp. 1-34. Open access 20 16 6
2022	Downes, CE, Rehn, J, Heatley, SL, Yeung, D, McClure, BJ & White, DL 2022, 'Identification of a novel GOLGA4-JAK2 fusion gene in B-cell acute lymphoblastic leukaemia', British Journal of Haematology, vol. 196, no. 3, pp. 700-705. 5 5 5
2022	Forgione, MO, McClure, BJ, Page, EC, Yeung, DT, Eadie, LN & White, DL 2022, 'TP53 loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137', Oncology Reports: An International Journal Devoted to Fundamental and Applied Research in Oncology, vol. 47, no. 5, article no. 99, pp. 1-7. Open access 1 1
2022	Heatley, SL, Page, EC, Eadie, LN, McClure, BJ, Rehn, J, Yeung, DT, Osborn, M, Revesz, T, Kirby, M & White, DL 2022, 'Case Report: Precision medicine target revealed by in vitro modeling of relapsed, refractory acute lymphoblastic leukemia from a child with neurofibromatosis', Frontiers in Oncology, vol. 12, article no. 851572, pp. 1-6. Open access 1 1 18
2022	Page, EC, Heatley, SL, Eadie, LN, McClure, BJ, de Bock, CE, Omari, S, Yeung, DT, Hughes, TP, Thomas, PQ & White, DL 2022, 'HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort', Oncogene, vol. 41, no. 6, pp. 797-808. 13 12 6
2022	Rehn, J, Mayoh, C, Heatley, SL, McClure, BJ, Eadie, L, Schutz, C, Yeung, DT, Cowley, MJ, Breen, J & White, DL 2022, 'RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL)', PLoS Genetics, vol. 18, no. 10, article no. e1010300, pp. 1-23. Open access 15 15 7
2022	Yip, KH, McKenzie, D, Ramshaw, HS, Chao, J, McClure, BJ, Pant, H, Grimbaldeston, MA, Hercus, TR, Lopez, AF & Tumes, DJ and 12 other authors 2022, 'Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model', Journal of Investigative Dermatology, vol. 142, no. 4, pp 1103-1113.e11. Open access 5 3 1
2021	Downes, CE, McClure, BJ, Bruning, JB, Page, E, Breen, J, Rehn, J, Yeung, DT & White, DL 2021, 'Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia', npj Precision Oncology, vol. 5, no. 1, article no. 75, pp. 1-13. Open access 18 17 7
2021	Heatley, SL, Asari, K, Schutz, CE, Leclercq, TM, McClure, BJ, Eadie, LN, Hughes, TP, Yeung, DT & White, D 2021, 'In-vitro modeling of TKI resistance in the high-risk B-cell acute lymphoblastic leukemia fusion gene RANBP2-ABL1 - implications for targeted therapy', Leukemia and Lymphoma, vol. 62, no. 5, pp. 1157-1166. 3 4
2021	Sutton, R, Dalla Pozza, L, Khaw, SL, Fraser, C, Revesz, T, Chamberlain, J, Mitchell, R, Trahair, TN, Bateman, CM, Venn, NC, Law, T, Ong, E, Heatley, SL, McClure, BJ, Meyer, C, Marschalek, R, Henderson, MJ, Cross, S, White, DL & Kotecha, RS 2021, 'Outcomes for Australian children with relapsed/refractory acute lymphoblastic leukaemia treated with blinatumomab', Pediatric Blood and Cancer, vol. 68, no. 5, article no. e28922, pp. 1-7. 18 16 1
2020	Forgione, MO, McClure, BJ, Eadie, LN, Yeung, DT & White, DL 2020, 'KMT2A rearranged acute lymphoblastic leukaemia: unravelling the genomic complexity and heterogeneity of this high-risk disease', Cancer Letters, vol. 469, pp. 410-418. 37 33
2020	Forgione, MO, McClure, BJ, Yeung, DT, Eadie, LN & White, DL 2020, 'MLLT10 rearranged acute leukemia: Incidence, prognosis, and possible therapeutic strategies', Genes Chromosomes and Cancer, vol. 59, no. 12, pp. 709-721. 9 9 4
2018	Dhagat, U, Hercus, TR, Broughton, SE, Nero, TL, Cheung Tung Shing, KS, Barry, EF, Thomson, CA, Bryson, S, Pai, EF, McClure, BJ, Schrader, JW, Lopez, AF & Parker, MW 2018, 'The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities', mAbs, vol. 10, no. 7, pp. 1018-1029. Open access 9 10 11
2018	McClure, BJ, Heatley, SL, Kok, CH, Sadras, T, An, J, Hughes, TP, Lock, RB, Yeung, D, Sutton, R & White, DL 2018, 'Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression', British Journal of Cancer, vol. 118, no. 7, pp. 1000-1004. Open access 31 27 7
2017	Sadras, T, Heatley, SL, Kok, CH, Dang, P, Galbraith, KM, McClure, BJ, Muskovic, W, Venn, NC, Moore, S, Osborn, M, Revesz, T, Moore, AS, Hughes, TP, Yeung, D, Sutton, R & White, DL 2017, 'Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions', Cancer Letters, vol. 408, pp. 92-101. 17 1
2017	Sadras, T, Heatley, SL, Kok, CH, McClure, BJ, Yeung, D, Hughes, TP, Sutton, R, Ziegler, DS & White, DL 2017, 'A novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH', Cancer Genetics, vol. 216, pp. 86-90. 12 11 2

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Austin Research Institute	AUSTRALIA
Australian Cancer Research Foundation	AUSTRALIA
Australian National University	AUSTRALIA
Children's Cancer Institute	AUSTRALIA
Goethe University Frankfurt	GERMANY
John Hunter Children's Hospital	AUSTRALIA
Murdoch Childrens Research Institute	AUSTRALIA
Queensland Children's Hospital	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Children's Hospital	UNITED KINGDOM
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Thomas Jefferson University	UNITED STATES
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Toronto	CANADA
University of Western Australia	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

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Barb McClure

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Work history

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Other

Teaching & student supervision

Highlights

Courses and programs

Gallery