Mr Ben Noll

Senior Technical Officer: Medicinal Chemistry/Senior Technical Officer UniSA Clinical & Health Sciences

City West Campus (HB7-25)
tel +61 8 830 21601

email Ben.Noll@unisa.edu.au

Research

Research focus

Pharmacology and Pharmaceutical Sciences
Medicinal and Biomolecular Chemistry
Oncology and Carcinogenesis
Paediatrics and Reproductive Medicine
Biological Sciences

Highlights

Analytical evaluation and pharmacokinetic analysis of Mnk inhibitors for targeted therapy in cancer.

Research

Outputs

Research outputs for the last seven years are shown below.

Open access indicates that an output is open access.

Journal Articles

Year	Output
2021	Sallustio, BC, Noll, BD, Hu, R, Barratt, DT, Tuke, J, Coller, JK, Russ, GR & Somogyi, AA 2021, 'Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients', British Journal of Clinical Pharmacology, 87, no. 10, pp. 3901-3909. 7 7
2021	Yu, M, Long, Y, Yang, Y, Li, M, Teo, T, Noll, B, Philip, S & Wang, S 2021, 'Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation', European Journal of Medicinal Chemistry, vol. 218, article no. 113391, pp. 1-23. 1 1
2021	Yu, M, Teo, T, Yang, Y, Li, M, Long, Y, Philip, S, Noll, B, Heinemann, GK, Diab, S, Eldi, P, Mekonnen, L, Anshabo, AT, Rahaman, MH, Milne, R, Hayball, JD & Wang, S 2021, 'Potent and orally bioavailable CDK8 inhibitors: design, synthesis, structure-activity relationship analysis and biological evaluation', European Journal of Medicinal Chemistry, vol. 214, pp. 1-22. 2 2 1
2020	Bantie, L, Tadesse, S, Likisa, J, Yu, M, Noll, B, Heinemann, G, Lokman, NA, Ricciardelli, C, Oehler, MK, Beck, A, Pradhan, R, Milne, R, Albrecht, H & Wang, S 2020, 'A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer', Gynecologic Oncology, vol. 159, no. 3, pp. 827-838. 5 6 1
2019	Abdelaziz, AM, Diab, S, Islam, S, KC Basnet, S, Noll, B, Li, P, Mekonnen, LB, Lu, J, Albrecht, H, Milne, RW, Gerber, C, Yu, M & Wang, S 2019, 'Discovery of n-phenyl-4-(1h-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent mnk2 inhibitors: design, synthesis, sar analysis, and evaluation of in vitro anti-leukaemic activity', Medicinal Chemistry, vol. 15, no. 6, pp. 600-621. 4 3
2019	Lee, KJ, Tieu, W, Blanco-Rodriguez, B, Paparella, AS, Yu, J, Hayes, A, Feng, J, Marshall, AC, Noll, B, Milne, R, Cini, D, Wilce, MC, Booker, GW, Bruning, JB, Polyak, SW & Abell, AD 2019, 'Sulfonamide-based inhibitors of biotin protein ligase as new antibiotic leads', ACS Chemical Biology, vol. 14, no. 9, pp. 1990-1997. Open access 3 3 3
2019	Rahaman, MH, Yu, Y, Zhong, L, Adams, J, Lam, F, Li, P, Noll, B, Milne, R, Peng, J & Wang, S 2019, 'CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia', Investigational New Drugs, vol. 37, no. 4, pp. 625-635. 16 15 3
2019	Sallustio, BC, Noll, BD, Coller, JK, Tuke, J, Russ, G & Somogyi, AA 2019, 'Relationship between allograft cyclosporin concentrations and P-glycoprotein expression in the 1st month following renal transplantation', British Journal of Clinical Pharmacology, vol. 85, no. 5, pp. 1015-1020. Open access 3 3
2018	Sweetman, MJ, Sebben, D, Noll, BD, Wang, WH, May, S, Mebberson, N, Plush, SE & Hayball, JD 2018, 'A rapid technique to determine performance and efficiency of activated carbon water filters', Water Science and Technology: Water Supply, vol. 18, no. 2, pp. 371-382. Open access 7 6
2018	Tadesse, S, Bantie, L, Tomusange, K, Yu, M, Islam, S, Bykovska, N, Noll, B, Zhu, G, Li, P, Lam, F, Kumarasiri, M, Milne, R & Wang, S 2018, 'Discovery and pharmacological characterisation of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents', British Journal of Pharmacology, vol. 175, no. 12, pp. 2399-2413. Open access 15 15 3
2017	Diab, S, Abdelaziz, AM, Li, P, Teo, T, Basnet, SK, Noll, B, Rahaman, MH, Lu, J, Hou, J, Yu, M, Le, BT, Albrecht, H, Milne, RW & Wang, S 2017, 'Dual inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia', European Journal of Medicinal Chemistry, vol. 139, pp. 762-772. Open access 15 14
2017	O'Brien-Brown, J, Jackson, A, Reekie, TA, Barron, ML, Werry, EL, Schiavini, P, McDonnell, M, Munoz, L, Wilkinson, S, Noll, B, Wang, S & Kassiou, M 2017, 'Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists', European Journal of Medicinal Chemistry, vol. 130, pp. 433-439. Open access 17 16 3
2017	Zeleke, S, Yu, M, Mekonnen, LB, Lam, F, Islam, S, Tomusange, K, Rahaman, MH, Noll, B, MC Basnet, S, Teo, T, Albrecht, H, Milne, R & Wang, S 2017, 'Highly potent, selective, and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependent kinases 4 and 6 inhibitors as anticancer drug candidates: design, synthesis, and evaluation', Journal of Medicinal Chemistry, vol. 60, no. 5, pp. 1892-1915. Open access 45 43 6
2016	Sutton, SK, Carter, DR, Kim, P, Tan, O, Arndt, GM, Zhang, XD, Baell, J, Noll, BD, Wang, S, Kumar, N, McArthur, GA, Cheung, BB & Marshall, GM 2016, 'A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner', Oncotarget, vol. 7, no. 32, pp. 52166-52178. Open access 8 7 1

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Guangzhou Medical University	CHINA
Monash University	AUSTRALIA
Peter MacCallum Cancer Centre	AUSTRALIA
Private Individual	AUSTRALIA
Puratap Pty Ltd	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Shandong University	CHINA
Sydney Children's Hospital	AUSTRALIA
University of Adelaide	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA

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Mr Ben Noll

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Research

Research focus

Highlights

Projects

Outputs

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

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