Dr Chia-Chi Chien

FoundationFellow (Research Fellow) Future Industries Institute

Mawson Lakes Campus (MM2-01G)
tel +61 8 830 23319

email Chia-Chi.Chien@unisa.edu.au

Research Degree Supervisor

About me

Dr Chia-Chi Chien is a Research Fellow at the Future Industries Institute, University of South Australia. She has obtained her PhD in Engineering and System Science in 2012 from the National Tsinghua University. During her PhD study she specialized in investigating the fate of nanoparticles in tumour cellular and animal models using advanced synchrotron x-ray imaging modalities. She has specifically developed numerical analysis methods for quantifying the tumor vasculature at the micro-scale, as well as novel approaches to image thick 3D tissues with subcellular resolution. She has also experience in the synthesis of biodegradable scaffold materials for guiding tissue regeneration as well as in the study of biomaterials biocompatibility... Read more

Future Industries Institute

The Institute partners with today’s industries, to create the industries of tomorrow.

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Research

Research themes

Transforming industries
Cancer
Healthy futures

Research focus

Engineering
Chemical Sciences
Condensed Matter Physics
Macromolecular and Materials Chemistry
Materials Engineering

Highlights

The current research interest she focuses on 3D vascularized tumour-on-chip technologies with nano/micro fluidic and biomedical systems to more accurately study biocompatibility and therapeutic efficiency of drugs in tumour tissue. These advanced platforms enable to mimic tumour micro-environment and utilize greater range of optical methods. Correlating these methods provides greater overview of physico-chemical properties coupled with biomolecular and physiological information. This provides novel insights into the biology of tumor microenvironment as well as enables development of novel functionalized nanoparticles.

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2019	Delon, LC, Guo, Z, Oszmiana, A, Chien, CC, Gibson, R, Prestidge, C & Thierry, B 2019, 'A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models', Biomaterials, vol. 225, Article number 119521 pp. 1-11.
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 58
2015	Lai, S-F, Ko, B-H, Chien, C-C, Chang, C-J, Yang, S-M, Chen, H-H, Petibois, C, Hueng, D-Y, Ka, S-M, Chen, A, Margaritondo, G & Hwu, Y 2015, 'Gold nanoparticles as multimodality imaging agents for brain gliomas', Journal of Nanobiotechnology, vol. 13, no. 1, article no. 85, pp. 1-8. Open access 15 15 2
2014	Cheng, C, Chien, C-C, Chen, H-H, Hwu, Y & Ching, Y 2014, 'Image alignment for tomography reconstruction from synchrotron x-ray microscopic images', PLoS One, vol. 9, no. 1, article no. e84675, pp. 1-9. Open access 8 6
2014	Liu, T, Chien, C-C, Parkinson, L & Thierry, B 2014, 'Advanced micromachining of concave microwells for long term on-chip culture of multicellular tumor spheroids', ACS Applied Materials and Interfaces, vol. 6, no. 11, pp. 8090-8097. 14 13
2013	Chien, C-C, Kempson, IM, Wang, CL, Chen, H, Hwu, Y, Chen, N, Lee, T, Tsai, KK-C, Liu, M-S, Chang, K-Y, Yang, C & Margaritondo, G 2013, 'Complete microscale profiling of tumor microangiogenesis. A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization.', Biotechnology Advances, vol. 31, no. 3, pp. 396-401. 7 8
2013	Chien, C-C, Tseng, P, Chen, H, Hua, T, Chen, S-T, Chen, Y, Leng, W-H, Wang, C, Hwu, Y, Yin, G, Liang, K, Chen, F, Chu, Y, Yeh, H, Yang, Y, Yang, C, Zhang, G, Je, J & Margaritondo, G 2013, 'Imaging cells and sub-cellular structures with ultrahigh resolution full-field X-ray microscopy', Biotechnology Advances, vol. 31, no. 3, pp. 375-386. 13 13 1
2013	Lai, S, Chien, C-C, Chen, W, Chen, H, Chen, Y, Wang, C-L, Hwu, Y, Yang, C, Chen, C, Liang, K, Petibois, C, Tan, H, Tok, ES & Margaritondo, G 2013, 'Very small photoluminescent gold nanoparticles for multimodality biomedical imaging', Biotechnology Advances, vol. 31, no. 3, pp. 362-368. 14 12 1
2013	Noreen, R, Chien, C-C, Chen, H, Bobroff, V, Moenner, M, Javersat, S, Hwu, Y & Petibois, C 2013, 'FTIR spectro-imaging of collagen scaffold formation during glioma tumor development', Analytical and Bioanalytical Chemistry, vol. 405, no. 27, pp. 8729-8736. 10 11 1
2012	Chien, C-C, Chen, H, Lai, S, Hwu, Y, Petibois, C, Yang, C, Chu, Y & Margaritondo, G 2012, 'X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells', Scientific Reports, vol. 2, pp. 1-6. Open access 17 15 1
2012	Chien, C-C, Chen, H-H, Lai, S, Wu, K, Cai, X, Hwu, Y, Petibois, C, Chu, Y & Margaritondo, G 2012, 'Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature', Journal of Nanobiotechnology, vol. 10, pp. 1-12. Open access 40 40 1
2012	Chien, C-C, Cheng, C, Chen, H-H, Hwu, Y, Chu, Y, Petibois, C, Chen, A, Ching, Y & Margaritondo, G 2012, 'X-ray microscopy and tomography detect the accumulation of bare and PEG-coated gold nanoparticles in normal and tumor mouse tissues', Analytical and Bioanalytical Chemistry, vol. 404, no. 5, pp. 1287-1296. 8 7 1
2012	Kempson, IM, Chien, C-C, Chung, C-Y, Hwu, Y, Paterson, D, de Jonge, MD & Howard, DL 2012, 'Fate of intravenously administered gold nanoparticles in hair follicles: follicular delivery, pharmacokinetic interpretation, and excretion', Advanced Healthcare Materials, vol. 1, no. 6, pp. 736-741. 14 14 8
2012	Lai, S, Chien, C-C, Chen, W, Chen, Y, Wang, C, Hwu, Y, Yang, C & Margaritondo, G 2012, 'Size control of gold nanoparticles by intense X-ray irradiation: The relevant parameters and imaging applications', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 2, no. 15, pp. 6185-6191. 7 7
2012	Tseng, S-J, Chien, C-C, Liao, Z, Chen, H-H, Kang, Y, Wang, C-L, Hwu, Y & Margaritondo, G 2012, 'Controlled hydrogel photopolymerization inside live systems by X-ray irradiation', Soft Matter, vol. 8, no. 5, pp. 1420-1427. 14 16 3
2012	Wu, H, Chen, S, CHU, Y, Conley, R, Bouet, N, Chien, C, Chen, H, Lin, C, Tung, H, Chen, Y, Margaritondo, G, Je, J & Hwu, Y 2012, 'Nanoresolution radiology of neurons', Journal of Physics D: Applied Physics, vol. 45, no. 24, pp. 1-4. 18 18 2
2011	Cai, X, Chen, H-H, Wang, C-L, Chen, S-T, Lai, S-F, Chien, C-C, Chen, Y-Y, Kempson, IM, Hwu, Y, Yang, CS & Margaritondo, G 2011, 'Imaging the cellular uptake of tiopronin-modified gold nanoparticles', Analytical and Bioanalytical Chemistry, vol. 401 no. 3, pp. 809-816. 22 19
2011	Chen, H-H, Chien, C-C, Petibois, C, Wang, C-L, Chu, YS, Lai, S-F, Hua, T-E, Chen, Y-Y, Cai, X, Kempson, IM, Hwu, Y & Margaritondo, G 2011, 'Quantitative analysis of nanoparticle internalization in mammalian cells by high resolution X-ray microscopy', Journal of Nanobiotechnology, vol. 9, no. 14, pp. 1-15. Open access 46 41
2011	Chien, C-C, Zhang, G, Hwu, Y, Liu, P, Yue, W, Sun, J, Li, Y, Xue, H, Xu, L, Wang, C, Chen, N, Lu, C, Lee, T-K, Yang, Y, Lu, Y, Ching, Y, Shih, TF, Yang, P-C, Je, J & Margaritondo, G 2011, 'Detecting small lung tumors in mouse models by refractive-index microradiology', Analytical and Bioanalytical Chemistry, vol. 401, no. 3, pp. 827-835. 1 1
2011	Lai, S-F, Chen, W-C, Wang, C-L, Chen, H-H, Chen, S-T, Chien, C-C, Chen, Y-Y, Hung, W-T, Cai, X, Li, E, Kempson, IM, Hwu, Y, Yang, C, Tok, E-S, Tan, HR, Lin, M & Margaritondo, G 2011, 'One-pot tuning of Au nucleation and growth: from nanoclusters to nanoparticles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 27 no. 13, pp. 8424-8429. 14 13
2011	Noreen, R, Chien, C-C, Delugin, M, Yao, S, Pineau, R, Hwu, Y, Moenner, M & Petibois, C 2011, 'Detection of collagens in brain tumors based on FTIR imaging and chemometrics', Analytical and Bioanalytical Chemistry, vol. 401, no. 3, pp. 845-852. 16 15 3
2011	Noreen, R, Pineau, R, Chien, C-C, Cestelli, GM, Hwu, Y, Marcelli, A, Moenner, M & Petibois, C 2011, 'Functional histology of glioma vasculature by FTIR imaging', Analytical and Bioanalytical Chemistry, vol. 401, no. 3, pp. 795-801. 12 11
2011	Wang, C-H, Liu, C-J, Chien, C-C, Chen, H-T, Hua, T-E, Leng, W-H, Chen, H-H, Kempson, IM, Hwu, Y, Hsiao, M, Lai, T-C, Wang, J, Yang, C-S, Lin, H-M, Chen, Y-J & Margaritondo, G 2011, 'X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors', Materials Chemistry and Physics, vol. 126 no. 1-2, pp. 352-356. 25 22
2011	Wang, C-L, Hsao, B-J, Lai, S-F, Chen, W-C, Chen, H-H, Chen, Y-Y, Chien, C-C, Cai, X, Kempson, IM, Hwu, Y & Margaritondo, G 2011, 'One-pot synthesis of AuPt alloyed nanoparticles by intense x-ray irradiation', Nanotechnology, vol. 22 no. 6, article no. 065605, pp. 1-7. 25 18
2010	Cai, X, Wang, C-L, Chen, H-H, Chien, C-C, Lai, S-F, Chen, Y-Y, Hua, T-E, Kempson, IM, Hwu, Y, Yang, CS & Margaritondo, G 2010, 'Tailored Au nanorods: Optimizing functionality, controlling the aspect ratio and increasing biocompatibility', Nanotechnology, vol. 21 no. 33, article no. 335604, pp. 1-8. 19 21
2010	Chien, C-C, Wang, C, Wang, C, Li, E, Lee, K, Hwu, Y, Lin, C, Chang, S, Yang, C, Petibois, C & Margaritondo, G 2010, 'Synchrotron microangiography studies of angiogenesis in mice with microemulsions and gold nanoparticles', Analytical and Bioanalytical Chemistry, vol. 397 no. 6, pp. 2109-2116. 22 21 3
2010	Liu, C-J, Wang, C, Chen, S-T, Chen, H-H, Leng, W-H, Chien, C-C, Wang, C-L, Kempson, IM, Hwu, Y, Lai, T-C, Hsiao, M, Yang, C-S, Chen, Y-J & Margaritondo, G 2010, 'Enhancement of cell radiation sensitivity by pegylated gold nanoparticles', Physics in Medicine and Biology, vol. 55, no. 4, pp. 931-945. 153 152
2009	Liu, C, Yang, T, Wang, X, Chien, C-C, Chen, S, Wang, C, Leng, W-H, Hwu, Y, Lin, G, Lee, KH, Chen, G-C, Je, JH & Margaritondo, G 2009, 'Enhanced photocatalysis, colloidal stability and cytotoxicity of synchrotron X-ray synthesized Au/TiO2 nanoparticles', Materials Chemistry and Physics, vol. 117, no. 1, pp. 74-79. 25 22
2009	Wang, C-H, Liu, C-J, Wang, C-L, Chien, C-C, Hwu, Y, Liu, R-S, Yang, C-S, Je, J-H, Lin, H-M & Margaritondo, G 2009, 'Intense X-ray induced formation of silver nanoparticles stabilized by biocompatible polymers', Applied Physics A: Materials Science and Processing, vol. 97 no. 2, pp. 295-300. 15 15
2008	Chu, YS, Yi, J, De Carlo, F, Shen, Q, Lee, W, Wu, H, Wang, X, Wang, J, Liu, C, Wang, C, Wu, Y, Chien, C-C, Hwu, Y, Tkachuk, A, Yun, W, Feser, M, Liang, W-K, Yang, C, Je, JH & Margaritondo, G 2008, 'Hard-x-ray microscopy with Fresnel zone plates reaches 40 nm Rayleigh resolution', Applied Physics Letters, vol. 92, no. 10. Open access 174 174
2008	Liu, C, Wang, C, Chien, C-C, Yang, T, Chen, S, Leng, W-H, Lee, C, Lee, KH, Hwu, Y, Lee, Y, Cheng, C, Yang, C, Chen, Y, Je, JH & Margaritondo, G 2008, 'Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification', Nanotechnology, vol. 19 no. 29, pp. 1-5. 85

Research

Patents

Details	Registry	Status
Method of tracking growth and metastasis of specific cells in vivo Hwu, Yeu-Kuang; Chien, Chia-Chi	US	Filed
Method of tracking specific cells in vivo Hwu, Yeu-Kuang; Chien, Chia-Chi; Wang, Cheng-Liang	US	Filed
Tumor vessel embolizing agent and method of embolizing tumor vessel Hwu, Yeu-Kuang; Chien, Chia-Chi	US	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Academia Sinica	TAIWAN
Australian Synchrotron Company Ltd	AUSTRALIA
Brookhaven National Laboratory	UNITED STATES
Chinese Academy of Sciences	CHINA
CNRS - Centre National de la Recherche Scientifique	FRANCE
Dana-Farber Cancer Institute	UNITED STATES
Ecole Polytechnique	FRANCE
Ecole Polytechnique Federale de Lausanne	ITALY
Ecole Polytechnique Federale De Lausanne	SWITZERLAND
Government College University	PAKISTAN
Harbin Institute of Technology	CHINA
Hefei University of Technology	CHINA
Hsinchu Mackay Memorial Hospital	TAIWAN
Inserm UMR	FRANCE
Istituto Nazionale Di Fiscia Nucleare	ITALY
Mackay Memorial Hospital	CHINA
Max Planck Institute of Colloids and Interfaces	GERMANY
National Center for High-Performance Computing	TAIWAN
National Cheng Kung University	TAIWAN
National Chiao Tung University	TAIWAN
National Defense Medical Center	TAIWAN
National Health Research Institute	CHINA
National Health Research Institutes	TAIWAN
National Synchrotron Radiation Research Centre (NSSRC)	TAIWAN
National Taiwan Ocean University	TAIWAN
National Taiwan University	TAIWAN
National Tsing Hua University	TAIWAN
National University of Singapore	SINGAPORE
National Yang Ming University	TAIWAN
National Yunlin University of Science and Technology	TAIWAN
Pohang University of Science and Technology	KOREA, REPUBLIC OF (SOUTH)
RMIT University	AUSTRALIA
Rome International Center for Materials Science Superstripes	ITALY
Royal Adelaide Hospital	AUSTRALIA
Shanghai Jiao Tong University	CHINA
St Jude Children's Research Hospital	UNITED STATES
Swinburne University of Technology	AUSTRALIA
Swiss Federal Institute of Technology Lausanne	SWITZERLAND
Tatung University	TAIWAN
Tri-Service General Hospital	TAIWAN
University of Auckland	NEW ZEALAND
University of Bordeaux	FRANCE
University of California, Berkeley	UNITED STATES
University of Newcastle	AUSTRALIA
University of South Australia	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Utah	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Winner, Winnovation Award (Science) Women in Innovation SA	2018
Assessor, Discovery Project Australian Research Council (ARC)	2015

Other

SYNCHROTRON X-RAY IMAGING USER2006-2009 User, Pohang Light Source, Pohang, Korean.2006-2012 User, National Synchrotron Radiation Research Center, Hsin-Chu, Taiwan2008-2012 User, Advanced Photon Source, Argonne, USA.

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Characterisation of extracellular matrix composition across the human brain and applications in brain organoid vascularisation	Current
Bioengineered vascularized microfluidic model: towards improved cancer therapy risk reduction and in vitro evaluation of the metastatic process	Completed
Detection and characterisation of rare disseminated cancer cells; towards improved patient prognostication	Completed

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Dr Chia-Chi Chien

About me

About me

Future Industries Institute

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Journal Articles

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Winner, Winnovation Award (Science)

Assessor, Discovery Project

Other

Teaching & student supervision

Courses and programs

Research degree supervision

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