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Dr Chih-Tsung Yang

  • Research Associate: Bioengineering Future Industries Institute
  • email Chih-Tsung.Yang@unisa.edu.au
  • Research Degree Supervisor
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About me

About me

Dr. Chih-Tsung Yang is a Research Associate at the Future Industries Institute. His interdisciplinary research expertise is centred on the fields of biomaterials, biosensing, microfluidics and organ-on-a-chip models. His current research is focused on the development of bioengineered human organs-on-a-chip models to evaluate the therapeutic efficiency of nanomedicine and radiation therapy protocols.

Prior to the start of his PhD, he significantly contributed to the liquid biopsy technology that underpinned the successful spin-off of CellMax Life ($15 million from VCs). He joined the University of South Australia as a PhD candidate in 2013 to develop amplification strategies of surface plasmon resonance biosensor towards the improved... Read more

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About me

Dr. Chih-Tsung Yang is a Research Associate at the Future Industries Institute. His interdisciplinary research expertise is centred on the fields of biomaterials, biosensing, microfluidics and organ-on-a-chip models. His current research is focused on the development of bioengineered human organs-on-a-chip models to evaluate the therapeutic efficiency of nanomedicine and radiation therapy protocols.

Prior to the start of his PhD, he significantly contributed to the liquid biopsy technology that underpinned the successful spin-off of CellMax Life ($15 million from VCs). He joined the University of South Australia as a PhD candidate in 2013 to develop amplification strategies of surface plasmon resonance biosensor towards the improved biosensing for cancer prognostics. The main tangible outcomes include; a biosensor able to identify metastatic tumour cells based on the concept of intracellular micromotion as well as the development of ultrasensitive signal amplification schemes for optical biosensors. His research is published in high quality peer reviewed international journals (72% in top 10% of their field).

Dr. Yang is actively engaged in his research community and is regularly invited to serve as a reviewer for peer-reviewed scientific journals (ACS Biomaterials Science & Engineering, ACS Applied Materials and Interfaces, Sensors, Optical Materials, Plos One and Applied Sciences). He is the UniSA node project leader of the signature project “Development of bioengineered multicellular systems” of the ARC Centre of Excellence for Convergent Bio-Nano Science &Technology (CBNS).

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Professional Associations

American Chemical Society 2019-

Australian Society of Medical Research 2018-

Australasian Biotechnology 2016-

Australian Nanotechnology Network (ANN) 2013-

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In the media

Date Title
18/03/2019

Aussies and Americans develop 3D models for assessing impacts of radiotherapy, https://www.dotmed.com/news/story/46575

14/03/2019

Using 3D models to reduce side effects of radiotherapy, https://www.eurekalert.org/pub_releases/2019-03/uosa-u3m031219.php

13/03/2019

3D models help reduce side effects of radiation therapy, https://www.appliedradiationoncology.com/articles/3d-models-help-reduce-side-effects-of-radiation-therapy

12/03/2019

Microfluidic chip could reduce radiotherapy side effects, http://theleadsouthaustralia.com.au/industries/health/microfluidic-chip-could-reduce-radiotherapy-side-effects/

12/03/2019

Microfluidic chip could reduce radiotherapy side effects, https://phys.org/news/2019-03-microfluidic-chip-radiotherapy-side-effects.html

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Experience

Qualifications

  • Doctor of Philosophy University of South Australia

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  • Professional associations
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Research

Research themes

  • Transforming industries
  • Cancer
  • Healthy futures

Research focus

  • Analytical Chemistry
  • Chemical Engineering
  • Chemical Sciences
  • Macromolecular and Materials Chemistry
  • Other Chemical Sciences

Highlights

Development of bioengineered muticellular systems.

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Projects

Excludes commercial-in-confidence projects.

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Outputs

Research since 2008 is shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year Output
2019

Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12.

58
2017

Yang, C-T, Pourhassan-Moghaddam, M, Wu, L, Bai, P & Thierry, B 2017, 'Ultrasensitive detection of cancer prognostic miRNA biomarkers based on surface plasmon enhanced light scattering', ACS Sensors, vol. 2, no. 5, pp. 635-640.

2016

Chen, J-Y, Tsai, W-S, Shao, H-J, Wu, J-C, Lai, J-M, Lu, S-H, Hung, T-F, Yang, C-T, Wu, L-C, Chen, J-S, Lee, W-H & Chang, Y-C 2016, 'Sensitive and specific biomimetic lipid coated microfluidics to isolate viable circulating tumor cells and microemboli for cancer detection', PLoS One, vol. 11, no. 3, article no. e0149633, pp. 1-21.

Open access 36 30 9
2016

Yang, C-T, Wu, L, Liu, X, Tran, NT, Bai, P, Liedberg, B, Wang, Y & Thierry, B 2016, 'Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality', Analytical Chemistry, vol. 88, no. 23, pp. 11924-11930.

12 11
2014

Yang, C-T, Méjard, R, Griesser, HJ, Bagnaninchi, PO & Thierry, B 2014, 'Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis', Analytical Chemistry, vol. 87, no. 3, pp 1456-1461.

25 23 1

Journal Articles

Year Output
2019

Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12.

58
2019

Tran, DP, Winter, M, Yang, C-T, Stockmann, R, Offenhausser, A & Thierry, B 2019, 'Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms', Analytical Chemistry, vol. 91, no. 19, pp. 12568-12573.

2019

Yang, C-T, Xu, Y, Pourhassan-Moghaddam, M, Tran, DP, Wu, L & Zhou, X 2019, 'Surface Plasmon Enhanced Light Scattering Biosensing: Size Dependence on the Gold Nanoparticle Tag', Sensors, vol. 19, no. 2, article no. 323, pp. 1-12.

Open access 2 2
2019

Zhou, X, Yang, C-T, Xu, Q, Lou, Z, Xu, Z, Thierry, B & Gu, N 2019, 'Gold nanoparticle probe-assisted antigen-counting chip using SEM', ACS Applied Materials and Interfaces, vol. 11, no. 7, pp 6769-6776.

2 1 7
2018

Chen, F, Tang, F, Yang, CT, Zhao, X, Wang, J, Thierry, B, Bansal, V, Dai, J & Zhou, X 2018, 'Fast and highly sensitive detection of pathogens wreathed with magnetic nanoparticles using dark-field microscopy', ACS Sensors, vol. 3, no. 10, pp. 2175-2181.

Open access 1
2017

Pai, J-H, Yang, C-T, Hsu, HY, Wedding, AB & Thierry, B 2017, 'Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers', Analytica Chimica Acta, vol. 974, pp. 87-92.

7 8 1
2017

Yang, C-T, Pourhassan-Moghaddam, M, Wu, L, Bai, P & Thierry, B 2017, 'Ultrasensitive detection of cancer prognostic miRNA biomarkers based on surface plasmon enhanced light scattering', ACS Sensors, vol. 2, no. 5, pp. 635-640.

2016

Chen, J-Y, Tsai, W-S, Shao, H-J, Wu, J-C, Lai, J-M, Lu, S-H, Hung, T-F, Yang, C-T, Wu, L-C, Chen, J-S, Lee, W-H & Chang, Y-C 2016, 'Sensitive and specific biomimetic lipid coated microfluidics to isolate viable circulating tumor cells and microemboli for cancer detection', PLoS One, vol. 11, no. 3, article no. e0149633, pp. 1-21.

Open access 36 30 9
2016

Duy Tran, Winter, M, Wolfrum, B, Stockmann, R, Yang, C-T, Pourhassan-Moghaddam, M, Offenhaüsser, A & Thierry, B 2016, 'Toward intraoperative detection of disseminated tumor cells in lymph nodes with silicon nanowire field effect transistors', ACS Nano, vol. 10, no. 2, pp. 2357-2364.

Open access 22 22 53
2016

Yang, C-T, Wu, L, Bai, P & Thierry, B 2016, 'Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags', Journal of Materials Chemistry C, vol. 4, no. 41, pp. 9897-9904.

15 17 1
2016

Yang, C-T, Wu, L, Liu, X, Tran, NT, Bai, P, Liedberg, B, Wang, Y & Thierry, B 2016, 'Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality', Analytical Chemistry, vol. 88, no. 23, pp. 11924-11930.

12 11
2015

Yang, C-T, Wang, Y, Frank, CW & Chang, Y-C 2015, 'Chemoresponsive surface-tethered polypeptide brushes based on switchable secondary conformations', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 5, no. 105, pp. 86113-86119.

4 4
2014

Liu, TM, Yang, C-T, Dieguez, LM, Denman, JA & Thierry, B 2014, 'Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation', ACS Applied Materials and Interfaces, vol. 6, no. 13, pp. 10162-10171.

4 4
2014

Yang, C-T, Méjard, R, Griesser, HJ, Bagnaninchi, PO & Thierry, B 2014, 'Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis', Analytical Chemistry, vol. 87, no. 3, pp 1456-1461.

25 23 1
2010

Yang, C-T, Wang, Y & Chang, Y-C 2010, 'Effect of solvents and temperature on the conformation of poly(beta-benzyl-L-aspartate) brushes', Biomacromolecules, vol. 11, no. 5, pp. 1308-1313.

20 18
2009

Yang, C-T, Wang, Y, Yu, S & Chang, Y-CI 2009, 'Controlled molecular organization of surface macromolecular assemblies based on stimuli-responsive polypeptide brushes', Biomacromolecules, vol. 10, no. 1, pp. 58-65.

23 22

Conferences

Year Output
2015

Yang, C-T & Thierry, B 2015, 'Comparison of sensor structures for the signal amplification of surface plasmon resonance immunoassay using enzyme precipitation', SPIE Micro+Nano Materials, Devices, and Applications 2015 Conference, SPIE, vol. 9668, article no. 96682J, pp. 1-7.

2 2
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Current research & highlights

Development of bioengineered muticellular systems.

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External engagement & recognition

Collaborations

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Collaborations

Organisation Country
Academia Sinica TAIWAN
Agency for Science, Technology and Research (A*STAR) SINGAPORE
Chang Gung Memorial Hospital TAIWAN
Chang Gung University TAIWAN
China Medical University TAIWAN
Chinese Academy of Sciences CHINA
Dana-Farber Cancer Institute UNITED STATES
Forschungszentrum Jülich GERMANY
High Performance Computing SINGAPORE
Nanjing Agricultural University CHINA
Nanjing Forestry University CHINA
Nanjing Medical University CHINA
Nanyang Technological University SINGAPORE
National Defense Medical Center TAIWAN
Peter Grunberg Institute (PGI) GERMANY
RMIT University AUSTRALIA
Royal Adelaide Hospital AUSTRALIA
Southeast University CHINA
Stanford University UNITED STATES
Tabriz University of Medical Sciences IRAN
University of California, Berkeley UNITED STATES
University of Edinburgh UNITED KINGDOM
University of North Carolina at Chapel Hill UNITED STATES
University of South Australia AUSTRALIA
University of Technology Sydney AUSTRALIA
Yangzhou University CHINA
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External engagement & recognition

Other

Keystone Symposia Future of Science Scholarship 2019

UniSA Coordinator Honours research projects 2018-

ARC CBNS UniSA node project leader 2017- 

Member of The Phi Tau Phi Scholastic Honor Society, Taiwan 2002-

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Courses and programs

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Research degree supervision

Supervisions from 2010 shown

Thesis title Student status
The role of metal nanoparticles and the metal core/metal oxinde shell structure when utilised as radiosensitisers in X-ray radiation therapy Current
Bioengineered vascularized microfluidic model: towards improved cancer therapy risk reduction and in vitro evaluation of the metastatic process Completed
Development of a solid-state biodiagnostic platform based on indium oxide nanoribbon field effect transistors Completed
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