Dr Chih-Tsung Yang

Research Fellow Future Industries Institute

Mawson Lakes Campus (MM2-01)
tel +61 8 830 26908

email Chih-Tsung.Yang@unisa.edu.au

Research Degree Supervisor

About me

Dr. Chih-Tsung Yang is a THRF EMCR Fellow at the Future Industries Institute. His interdisciplinary research expertise is centred on the fields of biomaterials, biosensing, microfluidics and organ-on-a-chip models. His current research is focused on the development of bioengineered human organs-on-a-chip models to evaluate the therapeutic efficiency of nanomedicine and radiation therapy protocols.

Dr. Yang is currently leading an ambitious research program “Towards Precision Cancer Radiotherapy: Development of a Radiogenomic Tool through Patient-Derived Tumour on-Chips Reconstructing the Tumour Microenvironment”. His most recent work has been focused on the development of bioengineered tumour/tissue models aimed ... Read more

Future Industries Institute

The Institute partners with today’s industries, to create the industries of tomorrow.

Tweets by @UniversitySA

Orcid
Scopus

About me

In the media

Date	Title
05/02/2023	New technology developed to diagnose porcine epidemic diarrhoea virus in pigs, https://www.theland.com.au/story/8072890/probing-researchers-strike-gold-to-stop-the-trots-in-pigs/
03/02/2023	Breakthrough in Detection of Lethal Pig Virus, https://www.technologynetworks.com/tn/news/breakthrough-in-detection-of-lethal-pig-virus-369848
02/02/2023	Probing researchers strike gold to stop the trots in pigs, https://www.eurekalert.org/news-releases/978627
27/02/2022	Improving Cancer Survivors’ Quality Of Life Headlines $1.7m Grants, https://hospitalresearch.org.au/news/latest-news/improving-cancer-survivors-quality-of-life-headlines-1-7m-grants/
18/03/2019	Aussies and Americans develop 3D models for assessing impacts of radiotherapy, https://www.dotmed.com/news/story/46575
14/03/2019	Using 3D models to reduce side effects of radiotherapy, https://www.eurekalert.org/pub_releases/2019-03/uosa-u3m031219.php
13/03/2019	3D models help reduce side effects of radiation therapy, https://www.appliedradiationoncology.com/articles/3d-models-help-reduce-side-effects-of-radiation-therapy
12/03/2019	Microfluidic chip could reduce radiotherapy side effects, http://theleadsouthaustralia.com.au/industries/health/microfluidic-chip-could-reduce-radiotherapy-side-effects/
12/03/2019	Microfluidic chip could reduce radiotherapy side effects, https://phys.org/news/2019-03-microfluidic-chip-radiotherapy-side-effects.html

Research

Research focus

Analytical Chemistry
Chemical Engineering
Materials Engineering
Other Chemical Sciences
Biomedical Engineering

Highlights

Development of microphysiological organ-on-chip towards precision radiotherapy.

● Linking response to radiation therapies with glioblastoma cell phenotype

● "Micropocket" for high-throughput preparation of tumouroids and screening of radiosensitisers

● Pumpless microfluidic perfusion device for long-term culture of brain tissue slices

● Development ofglioblastoma radiotherapy prognosis radiogenomic model

● 3D printed microtissue cassette for quantification of proton relative biological effectiveness

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2024	Nguyen, CTV, Chow, SKK, Nguyen, HN, Liu, T, Walls, A, Withey, S, Liebig, P, Mueller, M, Thierry, B, Yang, C-T & Huang, C-J 2024, 'Formation of zwitterionic and self-healable hydrogels via amino-yne click chemistry for development of cellular scaffold and tumor spheroid phantom for MRI', ACS Applied Materials and Interfaces, vol. 16, no. 28, pp. 36157-36167. Open access 2 2
2023	Hou, J, Qian, X, Xu, Y, Guo, Z, Thierry, B, Yang, CT, Zhou, X & Mao, C 2023, 'Rapid and reliable ultrasensitive detection of pathogenic H9N2 viruses through virus-binding phage nanofibers decorated with gold nanoparticles', Biosensors and Bioelectronics, vol. 237, article no. 115423. 17 16 3
2023	Hou, J, Xu, Y, Sun, S, Zhong, X, Yang, C-T & Zhou, X 2023, 'Gold nanoparticles-decorated M13 phage SPR probe for dual detection of antigen biomarkers in serum', Sensors and Actuators B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, vol. 374, article no. 132811, pp. 1-8. Open access 24 21
2022	Guo, Z, Yang, C-T, Chien, C-C, Selth, LA, Bagnaninchi, PO & Thierry, B 2022, 'Optical cellular micromotion: a new paradigm to measure tumor cells invasion within gels mimicking the 3D tumor environments', Small Methods, vol. 6, no. 8, article no. 2200471. Open access 9 9
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 30 28 58

Journal Articles

Year	Output
2025	Guan, B, Mills, S, Liu, T, Yang, C-T & Priest, C 2025, 'Integration of 3D-printed micro/nanostructures with interdigitated electrodes for low-matrix-effect sensing', ACS Applied Materials and Interfaces, online, pp. 1-11.
2025	Yang, CT, Cho, IC, Yu, CF, Cheah, E, Liu, T, Lin, YP, Hu, SY, Jheng, JW, Kempson, I, Chao, TC, Lee, SH, Bezak, E & Thierry, B 2025, '3D printed microtissue cassettes enabling high throughput proton radiobiological assays', Analytica Chimica Acta, vol. 1356, article no. 344027, pp. 1-7. Open access
2024	Nguyen, CTV, Chow, SKK, Nguyen, HN, Liu, T, Walls, A, Withey, S, Liebig, P, Mueller, M, Thierry, B, Yang, C-T & Huang, C-J 2024, 'Formation of zwitterionic and self-healable hydrogels via amino-yne click chemistry for development of cellular scaffold and tumor spheroid phantom for MRI', ACS Applied Materials and Interfaces, vol. 16, no. 28, pp. 36157-36167. Open access 2 2
2024	Shen, Y, Yang, CT, Li, W & Zhou, X 2024, 'Single-virus-sensitive barcode qPCR mediated by the aggregation of gold nanoparticle probes', The Analyst, vol. 149, pp. 2556-2560. Open access 1 1
2024	Wang, X, Lu, J, Huang, Y, Liu, X, Fang, G, Yang, CT & Guo, Z 2024, 'Editorial: Emerging bioanalytical techniques and therapies for human disease models', Frontiers in Bioengineering and Biotechnology, vol. 12, article no. 1453813, pp. 1-4. Open access
2024	Yuan, J, Zhu, H, Li, S, Thierry, B, Yang, C-T, Zhang, C & Zhou, X 2024, 'Truncated M13 phage for smart detection of E. coli under dark field', Journal of Nanobiotechnology, vol. 22, article no. 599, pp. 1-16. Open access 2 2
2023	Hou, J, Qian, X, Xu, Y, Guo, Z, Thierry, B, Yang, CT, Zhou, X & Mao, C 2023, 'Rapid and reliable ultrasensitive detection of pathogenic H9N2 viruses through virus-binding phage nanofibers decorated with gold nanoparticles', Biosensors and Bioelectronics, vol. 237, article no. 115423. 17 16 3
2023	Hou, J, Xu, Y, Sun, S, Zhong, X, Yang, C-T & Zhou, X 2023, 'Gold nanoparticles-decorated M13 phage SPR probe for dual detection of antigen biomarkers in serum', Sensors and Actuators B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, vol. 374, article no. 132811, pp. 1-8. Open access 24 21
2023	Shen, Y, Wang, J, Li, Y, Yang, CT & Zhou, X 2023, 'Modified bacteriophage for Tumor detection and targeted therapy', Nanomaterials, vol. 13, no. 4, article no. 665, pp. 1-18. Open access 11 10 1
2022	Guo, Z, Yang, C-T, Chien, C-C, Selth, LA, Bagnaninchi, PO & Thierry, B 2022, 'Optical cellular micromotion: a new paradigm to measure tumor cells invasion within gels mimicking the 3D tumor environments', Small Methods, vol. 6, no. 8, article no. 2200471. Open access 9 9
2022	Qian, X, Shen, Y, Yuan, J, Yang, CT & Zhou, X 2022, 'Visual and ultrasensitive detection of a Coronavirus using a Gold Nanorod Probe under dark field', Biosensors, vol. 12, no. 12, article no. 1146, pp. 1-13. Open access 6 6 43
2021	Hou, J, Shen, J, Zhao, N, Yang, CT, Thierry, B, Zhou, X, Zhu, J & Mao, C 2021, 'Detection of a single circulating tumor cell using a genetically engineered antibody-like phage nanofiber probe', Materials Today Advances, vol. 12, article no. 100168. Open access 13 14
2021	Jia, Z, Guo, Z, Yang, CT, Prestidge, C & Thierry, B 2021, ''Mucus-on-chip': a new tool to study the dynamic penetration of nanoparticulate drug carriers into mucus', International Journal of Pharmaceutics, vol. 598, article no. 120391, pp. 1-9. Open access 23 22
2021	Ni, C, Shen, Y, Li, Z, Yang, CT, Thierry, B, Yang, B & Zhou, X 2021, 'An ultrasensitive virus ELISA based on a magnetic mesoporous silica nanoprobe', Particle and Particle Systems Characterization, vol. 38, no. 11, article no. 2100146. 1 1
2021	Xu, H, Shen, J, Yang, C, Thierry, B, Zhu, Y, Mao, C & Zhou, X 2021, 'Naked-eye counting of pathogenic viruses by phage-gold nanobiomaterials as probes', Materials Today Advances, vol. 10, article no. 100122, pp. 1-6. Open access 15 14
2020	Chen, F, Di, T, Yang, C-T, Zhang, T, Thierry, B & Zhou, X 2020, 'Naked-eye enumeration of single chlamydia pneumoniae based on light scattering of gold nanoparticle probe', ACS Sensors, vol. 5, no. 4, pp. 1140-1148. 18 18 1
2020	Delon, LC, Guo, Z, Kashani, MN, Yang, CT, Prestidge, C & Thierry, B 2020, 'Hele Shaw microfluidic device: a new tool for systematic investigation into the effect of the fluid shear stress for organs-on-chips', MethodsX, vol 7, article no. 100980, pp. 1-17. Open access 5 5
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 30 28 58
2019	Tran, DP, Winter, M, Yang, C-T, Stockmann, R, Offenhausser, A & Thierry, B 2019, 'Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms', Analytical Chemistry, vol. 91, no. 19, pp. 12568-12573. Open access 17 16 1
2019	Yang, C-T, Xu, Y, Pourhassan-Moghaddam, M, Tran, DP, Wu, L & Zhou, X 2019, 'Surface Plasmon Enhanced Light Scattering Biosensing: Size Dependence on the Gold Nanoparticle Tag', Sensors, vol. 19, no. 2, article no. 323, pp. 1-12. Open access 23 21 1
2019	Zhou, X, Yang, C-T, Xu, Q, Lou, Z, Xu, Z, Thierry, B & Gu, N 2019, 'Gold nanoparticle probe-assisted antigen-counting chip using SEM', ACS Applied Materials and Interfaces, vol. 11, no. 7, pp 6769-6776. 13 11 7
2018	Chen, F, Tang, F, Yang, CT, Zhao, X, Wang, J, Thierry, B, Bansal, V, Dai, J & Zhou, X 2018, 'Fast and highly sensitive detection of pathogens wreathed with magnetic nanoparticles using dark-field microscopy', ACS Sensors, vol. 3, no. 10, pp. 2175-2181. Open access 20 21 1
2017	Pai, J-H, Yang, C-T, Hsu, HY, Wedding, AB & Thierry, B 2017, 'Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers', Analytica Chimica Acta, vol. 974, pp. 87-92. 28 24
2017	Yang, C-T, Pourhassan-Moghaddam, M, Wu, L, Bai, P & Thierry, B 2017, 'Ultrasensitive detection of cancer prognostic miRNA biomarkers based on surface plasmon enhanced light scattering', ACS Sensors, vol. 2, no. 5, pp. 635-640. 44 41
2016	Chen, J-Y, Tsai, W-S, Shao, H-J, Wu, J-C, Lai, J-M, Lu, S-H, Hung, T-F, Yang, C-T, Wu, L-C, Chen, J-S, Lee, W-H & Chang, Y-C 2016, 'Sensitive and specific biomimetic lipid coated microfluidics to isolate viable circulating tumor cells and microemboli for cancer detection', PLoS One, vol. 11, no. 3, article no. e0149633, pp. 1-21. Open access 64 54 15
2016	Duy Tran, Winter, M, Wolfrum, B, Stockmann, R, Yang, C-T, Pourhassan-Moghaddam, M, Offenhaüsser, A & Thierry, B 2016, 'Toward intraoperative detection of disseminated tumor cells in lymph nodes with silicon nanowire field effect transistors', ACS Nano, vol. 10, no. 2, pp. 2357-2364. Open access 56 51 51
2016	Yang, C-T, Wu, L, Bai, P & Thierry, B 2016, 'Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags', Journal of Materials Chemistry C, vol. 4, no. 41, pp. 9897-9904. 28 29 4
2016	Yang, C-T, Wu, L, Liu, X, Tran, NT, Bai, P, Liedberg, B, Wang, Y & Thierry, B 2016, 'Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality', Analytical Chemistry, vol. 88, no. 23, pp. 11924-11930. 27 24
2015	Yang, C-T, Wang, Y, Frank, CW & Chang, Y-C 2015, 'Chemoresponsive surface-tethered polypeptide brushes based on switchable secondary conformations', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 5, no. 105, pp. 86113-86119. 7 7
2014	Liu, TM, Yang, C-T, Dieguez, LM, Denman, JA & Thierry, B 2014, 'Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation', ACS Applied Materials and Interfaces, vol. 6, no. 13, pp. 10162-10171. 9 9
2014	Yang, C-T, Méjard, R, Griesser, HJ, Bagnaninchi, PO & Thierry, B 2014, 'Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis', Analytical Chemistry, vol. 87, no. 3, pp 1456-1461. 50 45
2010	Yang, C-T, Wang, Y & Chang, Y-C 2010, 'Effect of solvents and temperature on the conformation of poly(beta-benzyl-L-aspartate) brushes', Biomacromolecules, vol. 11, no. 5, pp. 1308-1313. 27 25
2009	Yang, C-T, Wang, Y, Yu, S & Chang, Y-CI 2009, 'Controlled molecular organization of surface macromolecular assemblies based on stimuli-responsive polypeptide brushes', Biomacromolecules, vol. 10, no. 1, pp. 58-65. 24 23

Conferences

Year	Output
2015	Yang, C-T & Thierry, B 2015, 'Comparison of sensor structures for the signal amplification of surface plasmon resonance immunoassay using enzyme precipitation', SPIE Micro+Nano Materials, Devices, and Applications 2015 Conference, SPIE, vol. 9668, article no. 96682J, pp. 1-7. 2 2

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Academia Sinica	TAIWAN
Agency for Science, Technology and Research (A*STAR)	SINGAPORE
Chang Gung Memorial Hospital	TAIWAN
Chang Gung University	TAIWAN
China Medical University, Taiwan	TAIWAN
Chinese Academy of Sciences	CHINA
Dana-Farber Cancer Institute	UNITED STATES
Flinders University	AUSTRALIA
Forschungszentrum Julich	GERMANY
Fudan University	CHINA
Guilin University of Electronic Technology	CHINA
High Performance Computing	SINGAPORE
Jiangsu University of Science and Technology	CHINA
Nanjing Agricultural University	CHINA
Nanjing Forestry University	CHINA
Nanjing Medical University	CHINA
Nanjing University	CHINA
Nanyang Technological University	SINGAPORE
National Central University	TAIWAN
National Defense Medical Center	TAIWAN
Peter Grunberg Institute (PGI)	GERMANY
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Shanghai University of Traditional Chinese Medicine	CHINA
Shimadzu Biomedical Research Laboratory	CHINA
Siemens Healthcare Adelaide	AUSTRALIA
Siemens Healthcare Germany	GERMANY
Siemens Healthineers International AG	SWITZERLAND
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Southeast University	CHINA
Stanford University	UNITED STATES
Tabriz University of Medical Sciences	IRAN
The Chinese University of Hong Kong (CUHK)	CHINA
The University of Tennessee Health Science Center	UNITED STATES
University of California	UNITED STATES
University of Edinburgh	UNITED KINGDOM
University of North Carolina at Chapel Hill	UNITED STATES
University Of Oklahoma Norman	UNITED STATES
University of South Australia	AUSTRALIA
University of Technology Sydney	AUSTRALIA
Yangzhou University	CHINA

External engagement & recognition

Engagement/recognition	Year
THRF EMCR Fellowship The Hospital Research Foundation Group	2022
Guest peer reviewer PLos One	2016
Guest peer reviewer Optical Materials	2016
Guest peer reviewer Elsevier Publishing	2016

Other

Keystone Symposia Future of Science Scholarship 2019

UniSA Coordinator Honours research projects 2018-

ARC CBNS UniSA node project leader 2017-

Member of The Phi Tau Phi Scholastic Honor Society, Taiwan 2002-

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
New radiobiological insights using a microphysiological device enabling long-term culture of patient-derived brain tumour tissue slices and cerebral organoid slices	Current
Next generation bioengineered in vitro tumour models	Current
Bioengineered vascularized microfluidic model: towards improved cancer therapy risk reduction and in vitro evaluation of the metastatic process	Completed
Development of a solid-state biodiagnostic platform based on indium oxide nanoribbon field effect transistors	Completed
Single cell analysis of gold and gold-core/silica-shell nanoparticles for radiosensitisation	Completed

more less

Dr Chih-Tsung Yang

About me

About me

Future Industries Institute

About me

Professional Associations

In the media

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Highlights

Journal Articles

Conferences

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

THRF EMCR Fellowship

Guest peer reviewer

Guest peer reviewer

Guest peer reviewer

Other

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery