Clifford is a Research Fellow at UniSA Clinical & Health Sciences.
He obtained a PhD in Biochemistry from Victoria University of Wellington after using gel-based proteomics to study the cellular effects of an algal toxin. His interests in proteomic technologies led the New Zealander to Denmark, where he spent time at the University of Southern Denmark and University of Copenhagen learning and implementing strategies to investigate the biological roles of protein post-translational modifications. These chemical additions are notoriously difficult to study because of their low abundance, which often require enrichment protocols and detection by high resolution mass spectrometry. Clifford also has extensive experience with liquid ... Read more
UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.
Clifford is a Research Fellow at UniSA Clinical & Health Sciences.
He obtained a PhD in Biochemistry from Victoria University of Wellington after using gel-based proteomics to study the cellular effects of an algal toxin. His interests in proteomic technologies led the New Zealander to Denmark, where he spent time at the University of Southern Denmark and University of Copenhagen learning and implementing strategies to investigate the biological roles of protein post-translational modifications. These chemical additions are notoriously difficult to study because of their low abundance, which often require enrichment protocols and detection by high resolution mass spectrometry. Clifford also has extensive experience with liquid chromatography and Orbitrap mass spectrometers, as well as performing selected/parallel reaction monitoring for the quantification of peptides and metabolites.
Clifford joined the Future Industries Institute (UniSA STEM) in 2018 before moving to UniSA Clinical & Health Sciences in 2021. He is enthusiastic about scientific collaborations with research groups and industrial companies in South Australia. Interested parties are welcome to contact Clifford for initial discussions.
Doctor of Philosophy Victoria University of Wellington
Excludes commercial-in-confidence projects.
Open access indicates that an output is open access.
Hua, Q, Young, C, Pukala, T, Martino, J, Hoffmann, P, Gillanders, B & Doubleday, Z 2023, 'Better late than never: optimising the proteomic analysis of field-collected octopus', PLoS One, vol. 18, no. 7, pp. 1-12.
Sebastian, S, Hoffmann, MK, Howard, D, Young, C, Washington, J, Unterweger, H, Alexiou, C, Turnbull, T, D'Andrea, R, Hoffmann, P & Kempson, I 2023, 'Kinetic effects of transferrin-conjugated gold nanoparticles on the antioxidant glutathione-thioredoxin pathway', Antioxidants, vol. 12, no. 8, article no. 16187, pp. 1-21.
Subramaniam, S, Joyce, P, Donnellan, L, Young, C, Wignall, A, Hoffmann, P & Prestidge, CA 2023, 'Protein adsorption determines pulmonary cell uptake of lipid-based nanoparticles', Journal of Colloid and Interface Science, vol. 641, pp. 36-47.
Open access 2 4
Donnellan, L, Young, C, Simpson, BS, Acland, M, Dhillon, VS, Costabile, M, Hoffmann, P & Deo, P 2022, 'Proteomic analysis of methylglyoxal modifications reveals susceptibility of glycolytic enzymes to dicarbonyl stress', International Journal of Molecular Sciences, vol. 23, no. 7, article no. 3689.
Open access 8 7 8
Donnellan, L, Young, C, Simpson, BS, Dhillon, VS, Costabile, M, Hoffmann, P, Fenech, M & Deo, P 2022, 'Methylglyoxal impairs sister chromatid separation in lymphocytes', International Journal of Molecular Sciences, vol. 23, no. 8, article no. 4139, pp. 1-11.
Open access 1 1
Lee, Y-R, Briggs, MT, Young, C, Condina, MR, Kuliwaba, JS, Anderson, PH & Hoffmann, P 2022, 'Mass spectrometry imaging spatially identifies complex-type N-glycans as putative cartilage degradation markers in human knee osteoarthritis tissue', Analytical and Bioanalytical Chemistry, vol. 414, no. 26, pp. 7597-7607.
Open access 3 1 5
Pham, QN, Winter, M, Milanova, V, Young, C, Condina, MR, Hoffmann, P, Pham, NT, Tung, TT, Losic, D & Thierry, B 2022, 'Magnetic enrichment of immuno-specific extracellular vesicles for mass spectrometry using biofilm-derived iron oxide nanowires', Nanoscale, vol. 15, no. 3, pp. 1236-1247.
1 1 1
Bastow, CR, Bunting, MD, Kara, EE, McKenzie, DR, Caon, A, Devi, S, Tolley, L, Mueller, SN, Frazer, IH, Harvey, N, Condina, MR, Young, C, Hoffmann, P, McColl, SR & Comerford, I 2021, 'Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration', Proceedings of the National Academy of Sciences of USA, vol. 118, no. 17, pp. 1-9.
Dilmetz, BA, Lee, Y-R, Condina, MR, Briggs, M, Young, C, Desire, CT, Klingler-Hoffmann, M & Hoffmann, P 2021, 'Novel technical developments in mass spectrometry imaging in 2020: a mini review', Analytical Science Advances, vol. 2, no. 3-4, pp. 225-237.
Open access 9 4
Young, C, Condina, MR, Briggs, MT, Moh, ES X, Kaur, G, Oehler, MK & Hoffmann, P 2021, 'In-house packed porous graphitic carbon columns for liquid chromatography-mass spectrometry analysis of n-glycans', Frontiers in Chemistry, vol. 9, article no. 653959, pp. 1-9.
Open access 9 6 4
Hendriks, IA, Lyon, D, Young, C, Jensen, LJ, Vertegaal, AC & Nielsen, ML 2017, 'Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation', Nature Structural and Molecular Biology, vol. 24, no. 3, pp. 325-336.
221 199 13
Young, C, Podtelejnikov, A V & Nielsen, ML 2017, 'Improved reversed phase chromatography of hydrophilic peptides from spatial and temporal changes in column temperature', Journal of Proteome Research, vol. 16, no. 6, pp. 2307-2317.
9 9 9
Martello, R, Leutert, M, Jungmichel, S, Bilan, V, Larsen, SC, Young, C, Hottiger, MO & Nielsen, ML 2016, 'Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue', Nature Communications, vol. 7, article no. 12917.
Open access 141 87 1
Madsen, CT, Sylvestersen, KB, Young, C, Larsen, SC, Poulsen, JW, Andersen, MA, Palmqvist, EA, Hey-Mogensen, M, Jensen, PB, Treebak, JT, Lisby, M & Nielsen, ML 2015, 'Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p', Nature Communications, vol. 6, article no. 7726, pp. 1-12.
Open access 43 40 2
Zub, KA, De Sousa, MML, Sarno, A, Sharma, A, Demirovic, A, Rao, S, Young, C, Aas, PA, Ericsson, I, Sundan, A, Jensen, ON & Slupphaug, G 2015, 'Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells', PLoS One, vol. 10, no. 3, pp. 1-20.
Open access 50 44 11
External engagement & recognition
|Norwegian University of Science and Technology NTNU||NORWAY|
|Novo Nordisk (Denmark)||DENMARK|
|Royal Adelaide Hospital||AUSTRALIA|
|University of Adelaide||AUSTRALIA|
|University of Copenhagen||DENMARK|
|University of Erlangen-Nuremberg||GERMANY|
|University of Melbourne||AUSTRALIA|
|University of Queensland||AUSTRALIA|
|University of Science, Malaysia||MALAYSIA|
|University of South Australia||AUSTRALIA|
|University of Southern Denmark||DENMARK|
|University of Sydney||AUSTRALIA|
|University of Zurich||SWITZERLAND|
Supervisions from 2010 shown
|Thesis title||Student status|
|111153 - Mass Spectrometry assays for protein biomarker for the early detection of ovarian cancer||Current|
|Advancing Protein Therapeutic Development||Current|
|Functional Analysis and Quantification of Biopharmaceuticals in Tissues by Mass Spectrometry Imaging||Current|
|Maximising yeast health during the industrial beer brewing process: a proteomics investigation||Current|
|PAT Spectroscopic and MS techniques for near/real-time product characterisation for plasmaderived products||Current|
|PAT Spectroscopic and MS techniques fornear/real-time product characterisation for plasma derived products||Current|