Professor Clive Prestidge

Professor UniSA Clinical & Health Sciences

City West Campus (HB6-16)
tel +61 8 830 22438

email Clive.Prestidge@unisa.edu.au

Alternative contact

Available for media comment
Research Degree Supervisor

About me

Professor of Pharmaceutical Science

Clive Prestidge is currently a Professor within Clinical and Health Science, a lead researcher within UniSA's Cancer Research Institute and head of the Nanostructure and Drug Delivery research group.

Clive is the author of over 250 refereed international journal articles, textbook chapters and conference papers and over 100 major project reports to industry. He has supervised more than 35 PhD, 10 MSc and 30 Honours students and has taken a leadership role in a number of major collaborative projects in association with national and international industries, the ARC, and University researchers from Australia and overseas. Prof Prestidge has attracted competitive research grants worth more than... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research themes

Transforming industries
Cancer
Healthy futures

Research focus

Chemical Sciences
Materials Engineering
Pharmacology and Pharmaceutical Sciences
Biomedical Engineering
Chemical Engineering

Highlights

Drug delivery systems
Pharmaceutical formulation and delivery
Nanomedicine
Biointerfaces

The Prestidge research group is focused on Nanomedicine and BioPharmaceutical Engineering. Its Primary Mission is to: (1) Engineer novel particle based biomaterials with specific biological activity and their application to solve biopharmaceutical challenges. (2) Determine mechanisms for bioactivity through advanced biophysical analysis (3) Develop drug delivery solutions to address unmet clinical needs. Some of our Grand Challenges are to: (1) Deliver Challenging Therapeutic Molecules – For Better Medicines (2) Eradicate Bacterial Biofilms (3) Optimise Biotech and Pharmaceutical Processing and Manufacture

Research

Projects

Excludes commercial-in-confidence projects.

Maximising the antimicrobial and anti-inflammatory performance of next generation therapeutics for Chronic Rhinosinusitis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, ARC - Centre of Excellence, 01/04/2014 - 29/06/2021
Optimization and validation of assay of French protocol for phenotyping patient samples for treatment optimization, Pari-Passou Medical Consultancy, 03/08/2020 - 31/12/2020
Mechanistic insight into Pharmako's Oral Curcumin Product: LipiSperse®, Pharmako Biotechnologies Pty Ltd, 03/10/2018 - 25/12/2019
Targeting particulate carriers to epithelial M cells, ARC - Linkage Project, 15/12/2015 - 30/09/2019
Targeting Particulate Carriers to Epithelial M Cells, CeramiSphere Pty Ltd, 01/01/2016 - 30/06/2019
Research Infrastructure Fund (RIF) Grant 2016 Round 2 - Biofilm Testing Facility, Adelaide Integrated Bioscience Laboratories, 28/11/2016 - 31/12/2017
Lipoceramic reformulation of simvastatin, Reformpharm Pty Ltd, 23/11/2016 - 31/12/2017
Mobilisation of endogenous mesenchymal progenitor cells for growth plate regeneration, NHMRC - Project Grant, 01/01/2013 - 31/12/2016
Improving the taste, bioavailability and efficacy of orally administered praziquantel for yellowtail kingfish with lipid nanoparticles and hybrid lipid carrier systems, Challenger Institute of Technology, 23/06/2015 - 30/09/2016
A novel nitric oxide-based treatment for recalcitrant Staphylococcus aureus-associated chronic rhinosinusitis (admin by Uni of Adelaide), NHMRC - Project Grant, 01/01/2013 - 30/06/2016
Harnessing lipid nano-assembly for next generation functional foods and pharmaceutical products, ARC - Discovery Projects, 01/01/2012 - 31/12/2015
A nanostructured drug delivery approach for improved colorectal cancer therapy, NHMRC - Project Grant, 01/01/2012 - 31/12/2015
Smart hybrid nano-biomaterials that mimic pharmaceutical food effect, ARC - Discovery Projects, 16/03/2012 - 30/09/2015
Advanced nanostructured biointerfaces for cell capture, ARC - Discovery Projects, 01/01/2008 - 30/06/2013

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2016	Dening, TJ, Rao, S, Thomas, N & Prestidge, CA 2016, 'Oral nanomedicine approaches for the treatment of psychiatric illnesses', Journal of Controlled Release, vol. 223, pp. 137-156. 27 27 1
2015	Delalat, B, Sheppard, VC, Rasi, GS, Rao, S, Prestidge, CA, McPhee, G, Rogers, M-L, Donoghue, JF, Pillay, V, Johns, TG, Kroger, N & Voelcker, NH 2015, 'Targeted drug delivery using genetically engineered diatom biosilica', Nature Communications, v 6, no. 8791, pp. 1-11. Open access 149 147 262
2015	Rao, S, Richter, K, Nguyen, T-H, Boyd, BJ, Porter, CJH, Tan, A & Prestidge, CA 2015, 'Pluronic-functionalized silica-lipid hybrid microparticles: improving the oral delivery of poorly water-soluble weak bases', Molecular Pharmaceutics, vol. 12, pp. 4424-4433. 26 20

Chapters

Year	Output
2020	Joyce, P, Schultz, HB, Meola, TR & Prestidge, CA 2020, Polymer lipid hybrid (PLH) formulations: a synergistic approach to oral delivery of challenging therapeutics, Elsevier, UK. 1
2016	Kempson, IM & Prestidge, CA 2016, 'Mass spectrometry imaging of pharmaceuticals: from tablets to tissues', in T Rades, Y Perrie & A Mullertz (eds), Analytical techniques in the pharmaceutical sciences, Springer, New York, ch. 19, pp. 629-647.
2014	Krasowska, M, Prestidge, CA & Beattie, DA 2014, 'Atomic force microscopy for determining surface interactions of relevance for food foams and emulsions', in YL Dar & JM Light (eds), Food texture design and optimization, John Wiley & Sons, UK, ch. 16, pp. 402-422. 6
2014	Prestidge, C & Barnes, T 2014, 'Nanoporous silicon to enhance drug solubility', in HA Santos (ed.), Porous silicon for biomedical applications, Woodhead Publishing, UK, ch. 15, pp. 356-373. 1
2012	Kempson, IM, Hwu, Y & Prestidge, CA 2012, 'Probing protein association with nano- and micro-scale structures with ToF-SIMS', in T Horbett, J L Brash & W Norde (eds), Proteins at interfaces III state of the art - volume 1120, American Chemical Society, US, ch. 33, pp. 709-729. 1 1
2008	Prestidge, CA 2008, 'From Novel Monodisperse 'Silicone Oil'/Water Emulsions to Drug Delivery', in Simon Biggs, Terence Cosgrove, Peter Dowding, New Frontiers in Colloid Science, RSC Publishing, London, pp. 70-89.

Journal Articles

Year	Output
2021	Arafat, M, Fouladian, P, Wignall, A, Song, Y, Parikh, A, Albrecht, H, Prestidge, CA, Garg, S & Blencowe, A 2021, 'Development and in vitro evaluation of 5-fluorouracil-eluting stents for the treatment of colorectal cancer and cancer-related obstruction', Pharmaceutics, vol. 13, no. 1, article no. 17, pp. 1-22. Open access 2 2 2
2021	Feizi, S, Cooksley, CM, Bouras, GS, Prestidge, CA, Coenye, T, Psaltis, AJ, Wormald, P-J & Vreugde, S 2021, 'Colloidal silver combating pathogenic Pseudomonas aeruginosa and MRSA in chronic rhinosinusitis', Colloids and Surfaces B: Biointerfaces, vol. 202, pp. 111675-111685. 3
2021	Jia, Z, Guo, Z, Yang, CT, Prestidge, C & Thierry, B 2021, ''Mucus-on-chip': a new tool to study the dynamic penetration of nanoparticulate drug carriers into mucus', International Journal of Pharmaceutics, vol. 598, article no. 120391, pp. 1-9.
2021	Jia, Z, Wignall, A, Prestidge, C & Thierry, B 2021, 'An ex vivo investigation of the intestinal uptake and translocation of nanoparticles targeted to Peyer's patches microfold cells', International Journal of Pharmaceutics, vol. 594, article no. 120167, pp. 1-7. 1
2021	Meola, T, Abuhelwa, AY, Joyce, P, Clifon, P & Prestidge, C 2021, 'A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants', Drug Delivery and Translational Research, vol. 11, no. 3, pp. 1261-1272. Open access 1 4
2021	Tam, JS, Coller, JK, Hughes, PA, Prestidge, CA & Bowen, JM 2021, 'Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation', Indian Journal of Gastroenterology, vol. 40, no. 1, pp. 5-21. Open access 2 2
2021	Thorn, CR, Carvalho-Wodarz, CdS, Horstmann, JC, Lehr, CM, Prestidge, CA & Thomas, N 2021, 'Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms', Small, vol. 17, no. 24, article no. 2100531, pp. 1-17. 3
2021	Thorn, CR, Howell, PL, Wozniak, DJ, Prestidge, CA & Thomas, N 2021, 'Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems', Advanced Drug Delivery Reviews, in press, pp. 1-18.
2021	Thorn, CR, Raju, D, Lacdao, I, Gilbert, S, Sivarajah, P, Howell, PL, Prestidge, CA & Thomas, N 2021, 'Protective liquid crystal nanoparticles for targeted delivery of PsIG: a biofilm dispersing enzyme', ACS Infectious Diseases, vol. 7, pp. 1-14. 64
2021	Thorn, CR, Thomas, N, Boyd, BJ & Prestidge, CA 2021, 'Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy', Drug Delivery and Translational Research, vol. 11, pp. 1598-1624. 4 3 4
2020	Al-Bayaty, N, Thomas, N, Ramírez-García, PD, Davis, TP, Quinn, JF, Whittaker, MR & Prestidge, CA 2020, 'PH-Responsive copolymer micelles to enhance itraconazole efficacy against: Candida albicans biofilms', Journal of Materials Chemistry B, vol. 8, no. 8, pp. 1672-1681. 10 9 32
2020	Almasri, R, Joyce, P, Schultz, HB, Thomas, N, Bremmell, KE & Prestidge, CA 2020, 'Porous nanostructure, lipid composition, and degree of drug supersaturation modulate in vitro fenofibrate solubilization in silica-lipid hybrids', Pharmaceutics, vol. 12, no. 7, article no. 687, pp. 1-12. Open access 2 1 2
2020	Alvebratt, C, Dening, TJ, Åhlén, M, Cheung, O, Strømme, M, Gogoll, A, Prestidge, CA & Bergström, CA 2020, 'In vitro performance and chemical stability of lipid-based formulations encapsulated in a mesoporous magnesium carbonate carrier', Pharmaceutics, vol. 12, no. 5, article no. 426, pp. 1-15. Open access 1 1 1
2020	Delon, LC, Guo, Z, Kashani, MN, Yang, CT, Prestidge, C & Thierry, B 2020, 'Hele Shaw microfluidic device: a new tool for systematic investigation into the effect of the fluid shear stress for organs-on-chips', MethodsX, vol 7, article no. 100980, pp. 1-17. Open access 1 1
2020	Delon, LC, Nilghaz, A, Cheah, E, Prestidge, C & Thierry, B 2020, 'Unlocking the potential of organ-on-chip models through pumpless and tubeless microfluidics', Advanced Healthcare Materials, vol. 9, no. 11, article no. 1901784, pp. 1-9. Open access 4 2 2
2020	Dong, D, Thomas, N, Ramezanpour, M, Psaltis, AJ, Huang, S, Zhao, Y, Thierry, B, Wormald, PJ, Prestidge, CA & Vreugde, S 2020, 'Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations', Experimental Biology and Medicine, vol. 245, no. 1, pp. 34-41. Open access 3 2 2
2020	Joyce, P, Dening, TJ, Meola, TR, Wignall, A, Ulmefors, H, Kovalainen, M & Prestidge, CA 2020, 'Contrasting anti-obesity effects of smectite clays and mesoporous silica in sprague-dawley rats', ACS Applied Bio Materials, vol. 3, no. 11, pp. 7779-7788.
2020	Joyce, P, Meola, TR, Schultz, HB & Prestidge, CA 2020, 'Biomaterials that regulate fat digestion for the treatment of obesity', Trends in Food Science and Technology, vol. 100, pp. 235-245. 3 4 5
2020	Joyce, P, Ulmefors, H, Garcia-Bennett, A & Prestidge, CA 2020, 'Microporosity, pore size, and diffusional path length modulate lipolysis kinetics of triglycerides adsorbed onto SBA-15 mesoporous silica particles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 36, no. 13, pp. 3367-3376. 5 4 1
2020	Joyce, P, Ulmefors, H, Maghrebi, S, Subramaniam, S, Wignall, A, Jõemetsa, S, Höök, F & Prestige, CA 2020, 'Enhancing the cellular uptake and antibacterial activity of rifampicin through encapsulation in mesoporous silica nanoparticles', Nanomaterials, vol.4, no.4, pp. 1-16. Open access 9 6
2020	Maghrebi, S, Jambhrunkar, M, Joyce, P & Prestidge, CA 2020, 'Engineering PLGA-lipid hybrid microparticles for enhanced macrophage uptake', ACS Applied Bio Materials, vol. 3, no. 7, pp. 4159-4167. 2 2
2020	Maghrebi, S, Joyce, P, Jambhrunkar, M, Thomas, N & Prestidge, CA 2020, 'Poly(lactic-co-glycolic) acid-lipid hybrid microparticles enhance the intracellular uptake and antibacterial activity of rifampicin', ACS Applied Materials and Interfaces, vol. 12, no. 7, pp. 8030-8039. 8 7 2
2020	Meola, TR, Paxton, K, Joyce, P, Schultz, HB & Prestidge, C 2020, 'The effect of drug ionization on lipid-based formulations for the oral delivery of anti-psychotics', ADMET and DMPK, vol. 8, no. 4, pp. 437-451. Open access 2 2
2020	Meola, TR, Schultz, HB, Peressin, KF & Prestidge, CA 2020, 'Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: the effect of supersaturation and silica geometry', European Journal of Pharmaceutical Sciences, vol. 150, article no. 105357, pp. 1-10. Open access 7 6 6
2020	Moller, A, Schultz, HB, Meola, TR, Mullertz, A & Prestidge, CA 2020, 'The Influence of solidification on the in vitro solubilisation of blonanserin loaded supersaturated lipid-based oral formulations', European Journal of Pharmaceutical Sciences, vol. 157, article no. 105640, pp. 1-10. 6
2020	Nimtrakul, P, Williams, DB, Tiyaboonchai, W & Prestidge, CA 2020, 'Copolymeric micelles overcome the oral delivery challenges of amphotericin B', Pharmaceuticals, vol. 13, no. 6, pp. 1-14. Open access 2 2 1
2020	Pohlen, M, Lavric, Z, Prestidge, C & Dreu, R 2020, 'Preparation, physicochemical characterisation and DoE optimisation of a spray-dried dry emulsion platform for delivery of a poorly soluble drug, simvastatin', AAPS PharmSciTech, vol. 21, no. 4, article no.119, pp. 1-19. 5 4 3
2020	Prestidge, CA, Schultz, HB, Wignall, AD & Thomas, N 2020, 'Enhancement of abiraterone acetate oral bioavailability by supersaturated-silica lipid hybrids', International Journal of Pharmaceutics, vol. 582, article no. 119264, pp. 1-10. Open access 3 2 204
2020	Romana, B, Hassan, MM, Sonvico, F, Garrastazu Pereira, G, Mason, AF, Thordarson, P, Bremmell, KE, Barnes, TJ & Prestidge, CA 2020, 'A liposome-micelle-hybrid (LMH) oral delivery system for poorly water-soluble drugs: enhancing solubilisation and intestinal transport', European Journal of Pharmaceutics and Biopharmaceutics, vol. 154, pp. 338-347. 3 5 11
2020	Schultz, HB, Joyce, P, Thomas, N & Prestidge, CA 2020, 'Supersaturated-silica lipid hybrids improve in vitro solubilization of abiraterone acetate', Pharmaceutical Research, vol. 37, no. 4, article number. 77, pp. 1-15. 6 6 13
2020	Schultz, HB, Meola, TR, Thomas, N & Prestidge, CA 2020, 'Oral formulation strategies to improve the bioavailability and mitigate the food effect of abiraterone acetate', International Journal of Pharmaceutics, vol. 577, article no. 119069, pp. 1-12. 14 12 8
2020	Thorn, CR, Clulow, AJ, Boyd, BJ, Prestidge, CA & Thomas, N 2020, 'Bacterial lipase triggers the release of antibiotics from digestible liquid crystal nanoparticles', Journal of Controlled Release, vol. 319, pp. 168-182. 10 9 11
2020	Wright, L, Barnes, TJ & Prestidge, CA 2020, 'Oral delivery of protein-based therapeutics: Gastroprotective strategies, physiological barriers and in vitro permeability prediction', International Journal of Pharmaceutics, vol. 585, article no. 119488, pp. 1-17. 8 8 6
2020	Wright, L, Joyce, P, Barnes, TJ, Lundmark, R, Bergström, CA, Hubert, M & Prestidge, CA 2020, 'A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics', Journal of Pharmaceutical Sciences, vol. 110, no. 1, pp. 217-227. 1 1 11
2019	Al-Bayaty, YN, Thomas, N, Jambhrunkar, M, Al-Hawwas, M, Kral, A, Thorn, CR & Prestidge, CA 2019, 'Enzyme responsive copolymer micelles enhance the anti-biofilm efficacy of the antiseptic chlorhexidine', International Journal of Pharmaceutics, vol. 566, pp. 329-341. Open access 8 6 4
2019	Bremmell, KE & Prestidge, CA 2019, 'Enhancing oral bioavailability of poorly soluble drugs with mesoporous silica based systems: opportunities and challenges', Drug Development and Industrial Pharmacy, vol. 45, no. 3, pp. 349-358. Open access 29 31
2019	Bremmell, KE, Briskey, D, Meola, TR, Mallard, A, Prestidge, CA & Rao, A 2019, 'A self-emulsifying Omega-3 ethyl ester formulation (AquaCelle) significantly improves eicosapentaenoic and docosahexaenoic acid bioavailability in healthy adults', European Journal of Nutrition, online, pp. 1-9. Open access 4 5 21
2019	Delon, LC, Guo, Z, Oszmiana, A, Chien, CC, Gibson, R, Prestidge, C & Thierry, B 2019, 'A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models', Biomaterials, vol. 225, Article number 119521 pp. 1-11. 30 29 2
2019	Dening, TJ, Joyce, P & Prestidge, CA 2019, 'Improving correlations between drug solubilization and in vitro lipolysis by monitoring the phase partitioning of lipolytic species for lipid-based formulations', Journal of Pharmaceutical Sciences, vol. 108, no. 1, pp. 295-304. Open access 10 8
2019	Dening, TJ, Joyce, P, Kovalainen, M, Gustafsson, H & Prestidge, CA 2019, 'Spray dried smectite clay particles as a novel treatment against obesity', Pharmaceutical Research, vol. 36, no. 1, article no. 21, pp. 1-14. 6 6 123
2019	Joyce, P, Dening, TJ, Meola, TR, Gustafsson, H, Kovalainen, M & Prestidge, CA 2019, 'Nanostructured clay particles supplement orlistat action in inhibiting lipid digestion: an in vitro evaluation for the treatment of obesity', European Journal of Pharmaceutical Sciences, vol. 135, pp. 1-11. 4 4 2
2019	Joyce, P, Dening, TJ, Meola, TR, Schultz, HB, Holm, R, Thomas, N & Prestidge, CA 2019, 'Solidification to improve the biopharmaceutical performance of SEDDS: opportunities and challenges', Advanced Drug Delivery Reviews, vol. 142, pp. 102-117. Open access 36 7 4
2019	Klisuric, A, Thierry, B, Delon, L, Prestidge, CA & Gibson, RJ 2019, 'Identifying human and murine M cells in vitro', Experimental Biology and Medicine, vol. 244, no. 7, pp. 554-564. Open access 2 1 4
2019	Maghrebi, S, Prestidge, CA & Joyce, P 2019, 'An update on polymer-lipid hybrid systems for improving oral drug delivery', Expert Opinion on Drug Delivery, vol. 16, no. 5, pp. 507-524. 18 13
2019	Partridge, GJ, Rao, S, Woolley, LD, Pilmer, L, Lymbery, AJ & Prestidge, CA 2019, 'Bioavailability and palatability of praziquantel incorporated into solid-lipid nanoparticles fed to yellowtail kingfish Seriola lalandi', Comparative Biochemistry and Physiology Part C, vol 218. pp. 14-20. Open access 3 3
2019	Pocock, K, Delon, LC, Khatri, A, Prestidge, C, Gibson, R, Barbe, C & Thierry, B 2019, 'Uptake of silica particulate drug carriers in an intestine-on-a-chip: towards a better in vitro model of nanoparticulate carrier and mucus interactions', Biomaterials Science, vol. 7, pp. 2410-2420. 14 12
2019	Subramaniam, S, Thomas, N, Gustafsson, H, Jambhrunkar, M, Kidd, SP & Prestidge, CA 2019, 'Rifampicin-loaded mesoporous silica nanoparticles for the treatment of intracellular infections', Antibiotics, vol. 8, no. 2, article no. 39, pp. 1-15. Open access 15 13 20
2019	Wang, F, Barnes, TJ & Prestidge, CA 2019, 'Controlling and predicting the dissolution kinetics of thermally oxidised mesoporous silicon particles: towards improved drug delivery', Pharmaceutics, vol. 11, no. 12, article no. 634, pp. 1-15. Open access 2 3
2018	Albayaty, YN, Thomas, N, Hasan, S & Prestidge, CA 2018, 'Penetration of topically used antimicrobials through Staphylococcus aureus biofilms: a comparative study using different models', Journal of Drug Delivery Science and Technology, vol. 48, pp. 429-436. 4 5 2
2018	Dening, TJ, Joyce, P, Webber, JL, Beattie, DA & Prestidge, CA 2018, 'Inorganic surface chemistry and nanostructure controls lipolytic product speciation and partitioning during the digestion of inorganic-lipid hybrid particles', Journal of Colloid and Interface Science, vol. 532, pp. 666-679. 12 10 5
2018	Faria, M, Björnmalm, M, Thurecht, KJ, Kent, SJ, Parton, RG, Kavallaris, M, Johnston, AP, Gooding, JJ, Corrie, SR, Boyd, BJ, Thordarson, P, Whittaker, AK, Stevens, MM, Prestidge, CA, Porter, CJ, Parak, WJ, Davis, TP, Crampin, EJ & Caruso, F 2018, 'Minimum information reporting in bio-nano experimental literature', Nature Nanotechnology, vol. 13, no. 9, pp. 777-785. Open access 243 234 125
2018	Hasan, S, Albayaty, YN, Thierry, B, Prestidge, CA & Thomas, N 2018, 'Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate', European Journal of Pharmaceutical Sciences, vol. 115, pp. 50-56. 2 2 1
2018	Joyce, P & Prestidge, CA 2018, 'Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base', European Journal of Pharmaceutical Sciences, vol. 118, pp. 40-48. 11 10 7
2018	Joyce, P, Gustafsson, H & Prestidge, CA 2018, 'Engineering intelligent particle-lipid composites that control lipase-mediated digestion', Advances in Colloid and Interface Science, vol. 260, pp. 1-23. 14 13
2018	Joyce, P, Gustafsson, H & Prestidge, CA 2018, 'Enhancing the lipase-mediated bioaccessibility of omega-3 fatty acids by microencapsulation of fish oil droplets within porous silica particles', Journal of Functional Foods, vol. 47, pp. 491-502. 15 15 2
2018	Meola, TR, Dening, TJ & Prestidge, CA 2018, 'Nanocrystal-silica-lipid hybrid particles for the improved oral delivery of ziprasidone in vitro', European Journal of Pharmaceutics and Biopharmaceutics, vol. 129, pp. 145-153. Open access 14 12 2
2018	Ooi, ML, Richter, K, Drilling, AJ, Thomas, N, Prestidge, CA, James, C, Moratti, S, Vreugde, S, Psaltis, AJ & Wormald, P-J 2018, 'Safety and efficacy of topical chitogel- deferiprone-gallium protoporphyrin in sheep model', Frontiers in Microbiology, vol. 9. article no. 917, pp. 1-9. Open access 8 8 1
2018	Schultz, HB, Kovalainen, M, Peressin, KF, Thomas, N & Prestidge, CA 2018, 'Supersaturated silica-lipid hybrid (super-SLH) oral drug delivery systems: balancing drug loading and in vivo performance', Journal of Pharmacology and Experimental Therapeutics, vol. 370, no. 3, pp. 742-750. Open access 4 5 6
2018	Schultz, HB, Thomas, N, Rao, S & Prestidge, CA 2018, 'Supersaturated silica-lipid hybrids (super-SLH): an improved solid-state lipid-based oral drug delivery system with enhanced drug loading', European Journal of Pharmaceutics and Biopharmaceutics, vol. 125, pp. 13-20. 27 28 4
2018	Su, YW, Chim, SM, Zhou, L, Hassanshahi, M, Chung, R, Fan, C, Song, Y, Foster, BK, Prestidge, CA, Peymanfar, Y, Tang, Q, Butler, LM, Gronthos, S, Chen, D, Xie, Y, Chen, L, Zhou, XF, Xu, J & Xian, CJ 2018, 'Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats', Bone, vol. 116, pp. 232-247. Open access 8 7 1
2018	Thorn, CR, Prestidge, CA, Boyd, BJ & Thomas, N 2018, 'Pseudomonas infection responsive liquid crystals for glycoside hydrolase and antibiotic combination', ACS Applied Bio Materials, vol. 1, no. 2, pp. 281-288. 6 10
2018	Wright, L, Rao, S, Thomas, N, Boulos, RA & Prestidge, CA 2018, 'Ramizol® encapsulation into extended release PLGA micro- and nanoparticle systems for subcutaneous and intramuscular administration: in vitro and in vivo evaluation', Drug Development and Industrial Pharmacy, online, pp. 1-7. 9 8 4
2017	Chang, PK, Prestidge, CA & Bremmell, KE 2017, 'Interfacial analysis of siRNA complexes with poly-ethylenimine (PEI) or PAMAM dendrimers in gene delivery', Colloids and Surfaces B: Biointerfaces, vol. 158, pp. 370-378. Open access 6 6
2017	Cifuentes-Rius, A, Ivask, A, Sporleder, E, Kaur, I, Assan, Y, Rao, S, Warther, D, Prestidge, CA, Durand, J-O & Voelcker, NH 2017, 'Dual-action cancer therapy with targeted porous silicon nanovectors', Small, vol. 13, article no. 1701201, pp. 1-6. Open access 19 17 12
2017	Dening, TJ, Rao, S, Thomas, N & Prestidge, CA 2017, 'Montmorillonite-lipid hybrid carriers for ionizable and neutral poorly water-soluble drugs: Formulation, characterization and in vitro lipolysis studies', International Journal of Pharmaceutics, vol. 526, no. 1-2, pp. 95-105. 19 17
2017	Hasan, S, Thomas, N, Thierry, B & Prestidge, CA 2017, 'Biodegradable nitric oxide precursor-loaded micro- and nanoparticles for the treatment of Staphylococcus aureus biofilms', Journal of Materials Chemistry B, vol. 5, pp. 1005-1014. Open access 14 14
2017	Hasan, S, Thomas, N, Thierry, B & Prestidge, CA 2017, 'Controlled and localized nitric oxide precursor delivery from chitosan gels to staphylococcus aureus biofilms', Journal of Pharmaceutical Sciences, vol. 106, no. 12, pp. 3556-3563. 4 3 1
2017	Joyce, P, Dening, TJ, Gustafsson, H & Prestidge, CA 2017, 'Modulating the lipase-mediated bioactivity of particle-lipid conjugates through changes in nanostructure and surface chemistry', European Journal of Lipid Science and Technology, vol. 119, no. 12, article no. 1700213 pp. 1-9. Open access 9 7
2017	Joyce, P, Yasmin, R, Bhatt, A, Boyd, BJ, Pham, A & Prestidge, CA 2017, 'Comparison across three hybrid lipid-based drug delivery systems for improving the oral absorption of the poorly water-soluble weak base cinnarizine', Molecular Pharmaceutics, vol. 14, no. 11, pp. 4008-4018. 16 14 6
2017	Mukherjee, S, Prestidge, CA, Orgeig, S, Panda, AK & Moulik, SP 2017, 'Physicochemical Investigation on the Pulmonary Surfactant of Some Vertebrates', Journal of Surface Science and Technology, vol. 33, no. 3-4, pp. 127-136.
2017	Pocock, K, Delon, L, Bala, V, Rao, S, Priest, C, Prestidge, C & Thierry, B 2017, 'Intestine-on-a-chip microfluidic model for efficient in vitro screening of oral chemotherapeutic uptake', ACS Biomaterial Science and Engineering, vol. 3, no. 6, pp. 951-959. 36 35
2017	Richter, K, Facal, P, Thomas, N, Vandecandelaere, I, Ramezanpour, M, Cooksley, C, Prestidge, CA, Coenye, T, Wormald, P-J & Vreugde, S 2017, 'Taking the silver bullet colloidal silver particles for the topical treatment of biofilm-related infections', ACS Applied Materials and Interfaces, vol. 9, no. 26, pp. 21631-21638. 25 25 3
2017	Richter, K, Thomas, N, Claeys, J, McGuane, J, Prestidge, C, Coenye, T, Wormald, PJ & Vreugde, S 2017, 'A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity', Antimicrobial Agents and Chemotherapy, vol. 61, no. 6, article no. e00481-17, pp. 1-32. Open access 31 28 11
2017	Richter, K, Thomas, N, Zhang, G, Prestidge, CA, Coenye, T, Wormald, PJ & Vreugde, S 2017, 'Deferiprone and gallium-protoporphyrin have the capacity to potentiate the activity of antibiotics in Staphylococcus aureus small colony variants', Frontiers in Cellular and Infection Microbiology, vol. 7 no. JUN, pp. 1-10. Open access 26 22 17
2017	Yasmin, R, Rao, S, Bremmell, KE & Prestidge, C 2017, 'Synergistic role of solid lipid and porous silica in improving the oral delivery of weakly basic poorly water soluble drugs', European Journal of Pharmaceutical Sciences, vol. 96, no. , pp. 508-514. 17 15
2016	Bala, V, Rao, S & Prestidge, CA 2016, 'Facilitating gastrointestinal solubilisation and enhanced oral absorption of SN38 using a molecularly complexed silica-lipid hybrid delivery system', European Journal of Pharmaceutics and Biopharmaceutics, vol.105, pp.32-39. 17 17 4
2016	Bala, V, Rao, S, Bateman, E, Keefe, DMK, Wang, S & Prestidge, CA 2016, 'Enabling oral SN38-based chemotherapy with a combined lipophilic prodrug and self-microemulsifying drug delivery system', Molecular Pharmaceutics, vol. 13, pp. 3518-3525. 28 26
2016	Bala, V, Rao, S, Li, P, Wang, S & Prestidge, CA 2016, 'Lipophilic prodrugs of SN38: synthesis and in vitro characterization toward oral chemotherapy', Molecular Pharmaceutics, vol. 13, no. 1, pp. 287-294. 43 42 16
2016	Chang, PK, Prestidge, CA, Barnes, TJ & Bremmell, KE 2016, 'Impact of PEGylation and non-ionic surfactants on the physical stability of the therapeutic protein filgrastim (G-CSF)', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, pp. 78970-78978. Open access 6 6
2016	Dening, TJ, Joyce, P, Rao, S, Thomas, N & Prestidge, CA 2016, 'Nanostructured montmorillonite clay for controlling the lipase-mediated digestion of medium chain triglycerides', ACS Applied Materials and Interfaces, vol. 8, no. 48, pp. 32732-32742. Open access 28 27
2016	Dening, TJ, Rao, S, Thomas, N & Prestidge, CA 2016, 'Oral nanomedicine approaches for the treatment of psychiatric illnesses', Journal of Controlled Release, vol. 223, pp. 137-156. 27 27 1
2016	Dening, TJ, Rao, S, Thomas, N & Prestidge, CA 2016, 'Silica encapsulated lipid-based drug delivery systems for reducing the fed/fasted variations of ziprasidone in vitro', European Journal of Pharmaceutics and Biopharmaceutics, vol. 101, pp. 33-42. 24 23
2016	Hasan, S, Thomas, N, Thierry, B, Vreugde, S, Wormald, P-J & Prestidge, CA 2016, 'Recent trends on the use of nanoparticles for nitric oxide delivery in antimicrobial applications', Drug Delivery Letters, vol. 6, no. 1, pp. 3-10. 2
2016	Joyce, P, Barnes, TJ, Boyd, BJ & Prestidge, CA 2016, 'Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, no. 82 , pp. 78385-78395. 29 28
2016	Joyce, P, Kempson, IM & Prestidge, CA 2016, 'Orientating lipase molecules through surface chemical control for enhanced activity: a QCM-D and ToF-SIMS investigation', Colloids and Surfaces B: Biointerfaces, vol.142, pp.173-181. 26 24
2016	Joyce, P, Whitby, CP & Prestidge, CA 2016, 'Interfacial processes that modulate the kinetics of lipase-mediated catalysis using porous silica host particles', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, no. 49, pp. 43802-43813. 22 23 1
2016	Joyce, P, Whitby, CP & Prestidge, CA 2016, 'Nanostructuring biomaterials with specific activities towards digestive enzymes for controlled gastrointestinal absorption of lipophilic bioactive molecules', Advances in Colloid and Interface Science, vol. 237, pp. 52-75. 24 24
2016	Liau, JJ, Prestidge, CA, Hook, S & Barnes, TJ 2016, 'Development of a multi-compartmental oral vaccine delivery system', Drug Delivery Letters, vol. 6, no. 1, pp. 57-62.
2016	Pocock, KJ, Gao, X, Wang, C, Priest, C, Prestidge, CA, Mawatari, K, Kitamori, T & Thierry, B 2016, 'Low-temperature bonding process for the fabrication of hybrid glass-membrane organ-on-a-chip devices', Journal of Micro/ Nanolithography, MEMS, and MOEMS, vol. 15, no. 4, pp. 1-9. 5 4
2016	Rao, S & Prestidge, CA 2016, 'Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to improve oral drug delivery', Expert Opinion on Drug Delivery, online, pp. 1-17. Open access 49 43 1
2016	Rao, S, Prestidge, CA, Miesel, L, Sweeney, DF, Shinabarger, DL & Boulos, RA 2016, 'Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis', Journal of Antibiotics: An International Journal Devoted to Research on Bioactive Microbial Products, vol. 69, no. 12, pp. 879-884. Open access 13 10 34
2016	Richter, K, Ramezanpour, M, Thomas, N, Prestidge, CA, Wormald, P-J & Vreugde, S 2016, 'Mind "De GaPP" : in vitro efficacy of deferiprone and gallium-protoporphyrin against Staphylococcus aureus biofilms', International Forum of Allergy and Rhinology, vol. 6, no. 7, pp. 737-743. 27 25 2
2016	Thomas, N, Thorn, C, Richter, K, Thierry, B & Prestidge, C 2016, 'Efficacy of poly-lactic-co-glycolic acid micro- and nanoparticles of ciprofloxacin against bacterial biofilms', Journal of Pharmaceutical Sciences, vol. 105, no. 10, pp.3115-3122. Open access 28 30 2
2016	Yasmin, R, Rao, S, Bremmell, KE & Prestidge, CA 2016, 'Porous Silica-Supported Solid Lipid Particles for Enhanced Solubilization of Poorly Soluble Drugs', AAPS Journal, vol. 18, no. 4, pp. 876-885. 7 8
2015	Alinaghi, A, Tan, A, Rao, S & Prestidge, CA 2015, 'Impact of solidification on the performance of lipid-based colloidal carriers: oil-based versus self-emulsifying systems', Current Drug Delivery, vol. 12, no. 1, pp. 16-25. Open access 11 12 3
2015	Bhatt, AB, Barnes, TJ & Prestidge, CA 2015, 'Silica nanoparticle stabilization of liquid crystalline lipid dispersions: impact on enzymatic digestion and drug solubilization', Current Drug Delivery, vol. 12, no. 1, pp. 47-55. 13 14
2015	Delalat, B, Sheppard, VC, Rasi, GS, Rao, S, Prestidge, CA, McPhee, G, Rogers, M-L, Donoghue, JF, Pillay, V, Johns, TG, Kroger, N & Voelcker, NH 2015, 'Targeted drug delivery using genetically engineered diatom biosilica', Nature Communications, v 6, no. 8791, pp. 1-11. Open access 149 147 262
2015	Dening, TJ, Rao, S, Thomas, N & Prestidge, CA 2015, 'Novel nanostructured solid materials for modulating oral drug delivery from solid-state lipid-based drug delivery systems', AAPS Journal, vol. 18, no. 23, pp. 23-40. Open access 42 40 3
2015	Dong, D, Thomas, N, Thierry, B, Vreugde, S, Prestidge, CA & Wormald, P-J 2015, 'Distribution and inhibition of liposomes on staphylococcus aureus and pseudomonas aeruginosa biofilm', PLoS One, vol. 10, no. 6, article no. e0131806, pp. 1-16. Open access 42 42 10
2015	Jardeleza, C, Thierry, B, Rao, S, Rajiv, S, Drilling, A, Miljkovic, D, Paramasivan, S, James, C, Dong, D, Thomas, N, Vreugde, S, Prestidge, CA & Wormald, P-J 2015, 'An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis', Translational Research: The Journal of Laboratory and Clinical Medicine, vol. 166, no. 6, pp. 683-692. Open access 19 18 1
2015	Joyce, P, Kempson, I & Prestidge, CA 2015, 'QCM-D and ToF-SIMS Investigation to Deconvolute the Relationship between Lipid Adsorption and Orientation on Lipase Activity', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 31, n. 37, pp. 10198-10207. 20 19
2015	Joyce, P, Whitby, CP & Prestidge, CA 2015, 'Bioactive hybrid particles from poly(D,L -lactide-co-glycolide) nanoparticle stabilized lipid droplets', ACS Applied Materials and Interfaces, vol. 7, pp. 17460-17470. 27 24 4
2015	Liau, JJ, Hook, S, Prestidge, CA & Barnes, TJ 2015, 'A lipid based multi-compartmental system: Liposomes-in-double emulsion for oral vaccine delivery', European Journal of Pharmaceutics and Biopharmaceutics, vol. 97, pp. 15-21. 20 18 1
2015	Miller, D, Parsons, M, Bresland, J, Herde, P, Pham, D, Tan, A, Hsu, H-Y, Prestidge, C, Kuchel, T, Begg, R, Aziz, M & Butler, R 2015, 'A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine', Zhejiang University Journal (Science B): International Biomedicine and Biotechnology Journal, vol. 16, no. 7, pp. 586-592. Open access 7 7 3
2015	Rao, S, Richter, K, Nguyen, T-H, Boyd, BJ, Porter, CJH, Tan, A & Prestidge, CA 2015, 'Pluronic-functionalized silica-lipid hybrid microparticles: improving the oral delivery of poorly water-soluble weak bases', Molecular Pharmaceutics, vol. 12, pp. 4424-4433. 26 20
2015	Thomas, N, Dong, D, Richter, K, Ramezanpour, M, Vreugde, S, Thierry, B, Wormald, P-J & Prestidge, CA 2015, 'Quatsomes for the treatment of Staphylococcus aureus biofilm', Journal of Materials Chemistry B, vol. 3, no. 14, pp. 2770-2777. 17 17
2014	Fong, W-K, Salentinig, S, Prestidge, CA, Mezzenga, R, Hawley, A & Boyd, B 2014, 'Generation of geometrically ordered lipid-based liquid-crystalline nanoparticles using biologically relevant enzymatic processing', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 30, no. 19, pp. 5373-5377. 30 29
2014	Jardeleza, C, Rao, S, Thierry, B, Gajjar, P, Vreugde, S, Prestidge, CA & Wormald, P-J 2014, 'Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms', PLoS One, vol. 9 no. 3, article no. e92117, pp. 1-9. Open access 28 25 1
2014	Joyce, P, Tan, A, Whitby, CP & Prestidge, CA 2014, 'The role of porous nanostructure in controlling lipase-mediated digestion of lipid loaded into silica particles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 30, no. 10, pp. 2779-2788. Open access 42 41
2014	Li, P, Tan, A, Prestidge, CA, Nielsen, HM & Mullertz, A 2014, 'Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading', International Journal of Pharmaceutics, vol. 477, pp. 390-398. 60 57 3
2014	Phan, S, Salentinig, S, Prestidge, CA & Boyd, BJ 2014, 'Self-assembled structures formed during lipid digestion: characterization and implications for oral lipid-based drug delivery systems', Drug Delivery and Translational Research, vol. 4, no. 3, pp. 275-294. Open access 36 34
2014	Rao, S, Tan, A, Boyd, BJ & Prestidge, CA 2014, 'Synergistic role of self-emulsifying lipids and nanostructured porous silica particles in optimizing the oral delivery of lovastatin', Nanomedicine, vol. 9, no. 18, pp. 2745-2759. 31 24
2014	Rao, S, Tan, A, Thomas, N & Prestidge, CA 2014, 'Perspective and potential of oral lipid-based delivery to optimize pharmacological therapies against cardiovascular diseases', Journal of Controlled Release, vol. 193, pp. 174-187. Open access 21 21 10
2014	Romana, B, Batger, M, Prestidge, CA, Colombo, G & Sonvico, F 2014, 'Expanding the therapeutic potential of statins by means of nanotechnology enabled drug delivery systems', Current Topics in Medicinal Chemistry, vol. 14, no. 9, pp. 1182-1193. Open access 33 29
2014	Roy, B, Panda, AK, Parimi, S, Ametov, I, Barnes, T & Prestidge, CA 2014, 'Physio-chemical studies on the interaction of dendrimers with lipid bilayers. 1. effect of dendrimer generation and liposome surface charge.', Journal of Oleo Science, vol. 63, no. 11, pp. 1185-1193. Open access 8 7
2014	Tan, A, Colliat-Dangus, P, Whitby, CP & Prestidge, CA 2014, 'Controlling the enzymatic digestion of lipids using hybrid nanostructured materials', ACS Applied Materials and Interfaces, vol. 6, no. 17, pp. 5363-5371. 17 14
2014	Yasmin, R, Tan, A, Bremmell, KE & Prestidge, CA 2014, 'Lyophilized silica-lipid hybrid carriers for poorly water-soluble drugs : physicochemical and in vitro pharmaceutical investigations', Journal of Pharmaceutical Sciences, vol. 103, no. 9, 2950-2959. 21 19 3
2013	Bala, V, Rao, S, Boyd, BJ & Prestidge, CA 2013, 'Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38', Journal of Controlled Release, vol. 172, no. 1, pp. 48-61. 131 124 14
2013	Barnes, TJ, Jarvis, KL & Prestidge, CA 2013, 'Recent advances in porous silicon technology for drug delivery', Therapeutic Delivery, vol. 4, no. 7, pp. 811-823. 23
2013	Bremmell, KE, Tan, A, Martin, A & Prestidge, CA 2013, 'Tableting lipid-based formulations for oral drug delivery: a case study with silica nanoparticle-lipid-mannitol hybrid microparticles', Journal of Pharmaceutical Sciences, vol. 102, no. 2, pp. 684-693. 28 29
2013	Kempson, IM, Chang, PKC, Bremmell, KE & Prestidge, CA 2013, 'Low temperature thermal dependent Filgrastim adsorption behavior detected with ToF-SIMS', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 29, no. 50, pp. 15573-15578. 9 10
2013	Lim, SP, Kumar, R, Akkamsetty, Y, Wang, W, Ho, K, Neilsen, P, Walther, DJ, Suetani, R, Prestidge, C & Callen, D 2013, 'Development of a novel cell-based assay system EPISSAY for screening epigenetic drugs and liposome formulated decitabine', BMC Cancer, vol. 13, article no. 113, pp. 1-13. Open access 5 3
2013	Nguyen, T-H, Tan, A, Santos, L, Ngo, D, Edwards, GA, Porter, CJ, Prestidge, CA & Boyd, BJ 2013, 'Silica-lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: an in vivo evaluation', Journal of Controlled Release, vol. 167, no. 1, pp. 85-91. 40 37 5
2013	Phan, S, Hawley, A, Mulet, X, Waddington, L, Prestidge, CA & Boyd, BJ 2013, 'Structural aspects of digestion of medium chain triglycerides studied in real time using sSAXS and cryo-TEM', Pharmaceutical Research, vol. 30, no. 12, pp. 3088-3100. 33 30
2013	Rudd, R, Vasilev, K, Prestidge, C & Simovic, S 2013, 'Polymeric nanosuspensions for enhanced dissolution of water insoluble drugs', Journal of Nanomaterials, vol. 2013, article no. 170201, pp. 1-10. Open access 3 2
2013	Tan, A & Prestidge, C 2013, 'Improving the performance of lipid formulations: nanoparticle layers and solid hybrid particles', American Pharmaceutical Review, vol. 16, no. 7, pp. 1-8. Open access 5
2013	Tan, A, Eskandar, NG, Rao, S & Prestidge, CA 2013, 'First in man bioavailability and tolerability studies of a silica-lipid hybrid (Lipoceramic) formulation: a Phase I study with ibuprofen', Drug Delivery and Translational Research, vol. 4, no. 3, pp. 212-221. 38 38
2013	Tan, A, Rao, S & Prestidge, CA 2013, 'Transforming lipid-based oral drug delivery systems into solid dosage forms: an overview of solid carriers, physicochemical properties, and biopharmaceutical performance', Pharmaceutical Research, vol. 30, no. 12, pp. 2993-3017. 103 96 6
2013	Wang, F, Barnes, TJ & Prestidge, CA 2013, 'Celecoxib confinement within mesoporous silicon for enhanced oral bioavailability', Mesoporous Biomaterials, vol. 1, no. 1, pp. 1-16. Open access
2012	Chan, JGY, Chan, H-k, Prestidge, CA, Denman, JA, Young, PM & Traini, D 2012, 'A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics', European Journal of Pharmaceutics and Biopharmaceutics, vol. 83, no. 2, pp. 285-292. 66 59 2
2012	Dong, Y-D, Larson, I, Barnes, TJ, Prestidge, CA, Allen, S, Chen, X, Roberts, CJ & Boyd, BJ 2012, 'Understanding the interfacial properties of nanostructured liquid crystalline materials for surface-specific delivery applications', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 28, no. 37, pp. 13485-13495. 24 23
2012	Ghouchi-Eskandar, N, Simovic, S & Prestidge, CA 2012, 'Solid-state nanoparticle coated emulsions for encapsulation and improving the chemical stability of all-trans-retinol', International Journal of Pharmaceutics, vol. 423, no. 2, pp. 384-391. 20 20
2012	Jarvis, KL, Barnes, TJ & Prestidge, CA 2012, 'Surface chemistry of porous silicon and implications for drug encapsulation and delivery applications', Advances in Colloid and Interface Science, vol. 175, pp. 25-38. 80 72
2012	Simovic, S, Barnes, TJ, Tan, A & Prestidge, CA 2012, 'Assembling nanoparticle coatings to improve the drug delivery performance of lipid based colloids', Nanoscale, vol. 4, no. 4, pp. 1220-1230. 40 37
2012	Tan, A & Prestidge, C 2012, 'Nanostructured silica-lipid hybrid microparticles: A supersaturating carrier for water- and lipid-resistant compounds', Chemistry Letters, vol. 41, pp. 1334-1336. Open access 17 16
2012	Tan, A, Martin, AL, Nguyen, T-H, Boyd, B & Prestidge, CA 2012, 'Hybrid nanomaterials that mimic the food effect : controlling enzymatic digestion for enhanced oral drug absorption', Angewandte Chemie, vol. 51, no. 22, pp. 5475-5479. 45 37 19
2012	Whitby, CP, Lim, LH, Ghouchi, EN, Simovic, S & Prestidge, CA 2012, 'Poly(lactic-co-glycolic acid) as a particulate emulsifier', Journal of Colloid and Interface Science, vol. 375, no. 1, pp. 142-147. Open access 14 14 6
2011	Barnes, TJ, Kempson, IM & Prestidge, CA 2011, 'Surface analysis for compositional, chemical and structural imaging in pharmaceutics with mass spectrometry: a ToF-SIMS perspective', International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 61-69. 37 38
2011	Dong, Y-D, Larson, I, Barnes, TJ, Prestidge, CA & Boyd, BJ 2011, 'Adsorption of nonlamellar nanostructured liquid-crystalline particles to biorelevant surfaces for improved delivery of bioactive compounds', ACS Applied Materials and Interfaces, vol. 3, no. 5, pp. 1771-1780. 39 36
2011	Ghouchi Eskandar, N, Simovic, S & Prestidge, CA 2011, 'Interactions of hydrophilic silica nanoparticles and classical surfactants at non-polar oil-water interface', Journal of Colloid and Interface Science, vol. 358, no. 1, pp. 217-225. 43 35
2011	Jarvis, KL, Barnes, TJ & Prestidge, CA 2011, 'Surface chemical modification to control molecular interactions with porous silicon', Journal of Colloid and Interface Science, vol. 363, no. 1, pp. 327-333. 28 23 3
2011	Kurkuri, MD, Al-Ejeh, F, Shi, JY, Palms, D, Prestidge, C, Griesser, HJ, Brown, MP & Thierry, B 2011, 'Plasma functionalized PDMS microfluidic chips : towards point-of-care capture of circulating tumor cells', Journal of Materials Chemistry, vol. 21, no. 24, pp. 8841-8848. 31 29 9
2011	Lim, LH, Tan, A, Simovic, S & Prestidge, CA 2011, 'Silica-lipid hybrid microcapsules: influence of lipid and emulsifier type on in vitro performance', International Journal of Pharmaceutics, vol. 409, no. 1-2, pp. 297-306. 31 29
2011	Simovic, S, Ghouchi-Eskandar, N & Prestidge, C 2011, 'Pickering emulsions for dermal delivery', Journal of Drug Delivery Science and Technology, vol. 21, no. 1, pp. 123-133. 32 29
2011	Simovic, S, Ghouchi-Eskandar, N, Sinn Aw Moom, Losic, D & Prestidge, CA 2011, 'Silica materials in drug delivery applications', Current Drug Discovery Technologies, vol. 8, no. 3, pp. 250-268. 37
2011	Tan, A, Davey, AK & Prestidge, CA 2011, 'Silica-lipid hybrid (SLH) versus non-lipid formulations for optimising the dose-dependent oral absorption of Celecoxib', Pharmaceutical Research, vol. 28, no. 9, pp. 2273-2287. 44 45 6
2010	Jarvis, K, Barnes, TJ & Prestidge, CA 2010, 'Thermal Oxidation for Controlling Protein Interactions with Porous Silicon', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 26, no. 17, pp. 14316-14322. 40 38
2010	Kempson, IM, Barnes, TJ & Prestidge, CA 2010, 'Use of TOF-SIMS to study adsorption and loading behavior of methylene blue and papain in a nano-porous silicon layer', Journal of the American Society for Mass Spectrometry, vol. 21, no. 2, pp. 254-260. Open access 24 18
2010	Kempson, IM, Martin, AL, Denman, JA, French, PW, Prestidge, CA & Barnes, TJ 2010, 'Detecting the Presence of Denatured Human Serum Albumin in an Adsorbed Protein Monolayer Using TOF-SIMS', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 26, no. 14, pp. 12075-12080. 29 29
2010	Panda, A, Vasilev, KA, Orgeig, S & Prestidge, CA 2010, 'Thermodynamic and structural studies of mixed monolayers: Mutual mixing of DPPC and DPPG with DoTAP at the air-water interface', Materials Science and Engineering C: Materials for Biological Applications, vol. 30, no. 4, pp. 542-548. 16 14
2010	Parimi, S, Barnes, TJ, Callen, D & Prestidge, CA 2010, 'Mechanistic Insight into Cell Growth, Internalization, and Cytotoxicity of PAMAM Dendrimers', Biomacromolecules, vol. 11, no. 2, pp. 382-389. 44 43
2010	Simovic, S, Heard, P & Prestidge, CA 2010, 'Hybrid lipid-silica microcapsules engineered by phase coacervation of Pickering emulsions to enhance lipid hydrolysis', Physical Chemistry Chemical Physics, vol. 12, no. 26, pp. 7162-7170. 22 19
2010	Simovic, S, Hui, H, Song, Y, Davey, AK, Rades, T & Prestidge, CA 2010, 'An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles', Journal of Controlled Release, vol. 143, no. 3, pp. 367-373. 78 57
2010	Tan, A, Simovic, S, Davey, AK, Rades, T, Boyd, BJ & Prestidge, CA 2010, 'Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems', Molecular Pharmaceutics, vol. 7, no. 2, pp. 522-532. 83 74
2010	Vellore Janarthanan, M, Barnes, TJ & Prestidge, CA 2010, 'Silica nanoparticle coated liposomes: A new type of hybrid nanocapsule for proteins', International Journal of Pharmaceutics, vol. 392, no. 1-2, pp. 285-293. 108 98
2010	Wang, FF, He, H, Barnes, TJ, Barnett, C & Prestidge, CA 2010, 'Oxidized Mesoporous Silicon Microparticles for Improved Oral Delivery of Poorly Soluble Drugs', Molecular Pharmaceutics, vol. 7, no. 1, pp. 227-236. 121 106
2009	Er, Y, Barnes, TJ, Fornasiero, D & Prestidge, CA 2009, 'The encapsulation and release of guanosine from PEGylated liposomes', Journal of Liposome Research, vol. 19, no. 1, pp. 29-36. 26 23
2009	Eskandar, NG, Simovic, S & Prestidge, CA 2009, 'Chemical stability and phase distribution of all-trans-retinol in nanoparticle-coated emulsions', International Journal of Pharmaceutics, vol. 376, no. 1-2, pp. 186-194. 65 57
2009	Eskandar, NG, Simovic, S & Prestidge, CA 2009, 'Nanoparticle coated submicron emulsions: sustained in-vitro release and improved dermal delivery of all trans-retinol', Pharmaceutical Research, vol. 26, no. 7, pp. 1764-1775. 64 56
2009	Ghouchi Eskandar, N, Simovic, S & Prestidge, CA 2009, 'Mechanistic insight into the dermal delivery from nanoparticle-coated submicron O/W emulsions', Journal of Pharmaceutical Sciences, vol. 99, no. 2, pp. 890-904. 29 24
2009	Ghouchi Eskandar, N, Simovic, S & Prestidge, CA 2009, 'Nanoparticle coated emulsions as novel dermal delivery vehicles', Current Drug Delivery, vol. 6, no. 4, pp. 367-373. 16
2009	Simovic, S, Heard, P, He, H, Song, Y, Peddie, F, Davey, AK, Lewis, A, Rades, T & Prestidge, CA 2009, 'Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs', Molecular Pharmaceutics, vol. 6, no. 3, pp. 861-872. 91 81
2009	Tan, A, Simovic, S, Davey, AK, Rades, T & Prestidge, CA 2009, 'Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs', Journal of Controlled Release, vol. 134, no. 1, pp. 62-70. 149 133
2008	Barnes, TJ, Ametov, I & Prestidge, CA 2008, 'Dendrimer adsorption on charged particulate surfaces', Asia Pacific Journal of Chemical Engineering, vol. 3, no. 1, pp. 13-17. 4 5
2008	Barnes, TJ, Ametov, I & Prestidge, CA 2008, 'Naphthalene sulfonate functionalized dendrimers at the solid-liquid interface: Influence of core type, ionic strength, and competitive ionic adsorbates', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 21, pp. 12398-12404. 4 4
2008	Barnes, TJ, Jarvis, K & Prestidge, CA 2008, 'Aqueous and Thermal Oxidation of Porous Silicon Microparticles: Implications on Molecular Interactions', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 24, pp. 14222-14226. 33 32
2008	Britcher, LG, Barnes, TJ, Griesser, HJ & Prestidge, CA 2008, 'PEGylation of Porous Silicon Using Click Chemistry', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 15, pp. 7625-7627. 44 42
2008	Jarvis, K, Barnes, TJ, Badalyan, A, Pendleton, P & Prestidge, CA 2008, 'Impact of thermal oxidation on the adsorptive properties and structure of porous silicon particles', The Journal of Physical Chemistry C: Energy Conversion and Storage, Optical and Electronic Devices, Interfaces, Nanomaterials, and Hard Matter, vol. 112, no. 26, pp. 9717-9722. 33 29
2008	Parimi, S, Barnes, TJ & Prestidge, CA 2008, 'PAMAM dendrimer interactions with supported lipid bilayers: A kinetic and mechanistic investigation', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 23, pp. 13532-13539. 51 51
2008	Prestidge, CA, Barnes, TJ, Mierczynska-Vasilev, A, Kempson, IM, Peddie, F & Barnett, C 2008, 'Peptide and Protein Loading into Porous Silicon Wafers', Physica Status Solidi A: Applications and Materials Science, vol. 205, no. 2, pp. 311-315. 41 38
2008	Saiki, Y, Horn, RG & Prestidge, CA 2008, 'Droplet structure instability in concentrated emulsions', Journal of Colloid and Interface Science, vol. 320, no. 2, pp. 569-574. 18 15
2008	Saiki, Y, Horn, RG & Prestidge, CA 2008, 'Rheological transition of concentrated emulsions during successive shearing cycles', Journal of Colloid and Interface Science, vol. 327, no. 2, pp. 440-445. Open access 7 7
2008	Simovic, S & Prestidge, CA 2008, 'Colloidosomes from the Controlled Interaction of Submicrometer Triglyceride Droplets and Hydrophilic Silica Nanoparticles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 14, pp. 7132-7137. 28 25

Conferences

Year	Output
2015	Pocock, KJ, Gao, X, Wang, C, Priest, C, Prestidge, C, Mawatari, K, Kitamori, T & Thierry, B 2015, 'Low-temperature bonded glass-membrane microfluidic device for in vitro organ-on-a-chip cell culture models', SPIE Micro+nano materials, devices, and applications symposium, SPIE - The International Society for Optical Engineering, vol. 9668, article no. 96690W, pp. 1-8. 1

Research

Patents

Details	Registry	Status
Dried formulations of nanoparticle-coated capsules Prestidge, Clive Allan; Simovic, Spomenka	AU	Granted
Dried formulations of nanoparticle-coated capsules Prestidge, Clive Allan; Simovic, Spomenka	JP	Granted
Dried formulations of nanoparticle-coated capsules Prestidge, Clive Allan; Simovic, Spomenka	US	Granted
Drug delivery composition comprising polymer-lipid hybrid microparticles Prestidge, Clive Allan; Joyce, Paul Matthew	Australia	Filed
Drug release from nanoparticle-coated capsules Prestidge, Clive Allan; Simovic, Spomenk; Ghouchi Eskandar, Nasrin	AU	Granted
Drug release from nanoparticle-coated capsules Prestidge, Clive; Simovic, Spomenk; Ghouchi, Eskandar Nasrin	EP	Filed
Drug release from nanoparticle-coated capsules Prestidge, Clive; Simovic, Spomenk; Ghouchi, Eskandar Nasrin	US	Granted
Drug release from nanoparticle-coated capsules Prestidge, Clive; Simovic, Spomenk; Ghouchi Eskandar, Nasrin	WO	Filed
Nanoparticle-stabilized capsule formulation for treatment of inflammation Prestidge, Clive; Simovic, Spomenk	US	Granted

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Academia Sinica	TAIWAN
Adelaide Pathology Partners	AUSTRALIA
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology	AUSTRALIA
Australian Centre for Applied Aquaculture Research	AUSTRALIA
Australian Nuclear Science Technology Organisation	AUSTRALIA
Australian Synchrotron Company Ltd	AUSTRALIA
Behala College	INDIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Ceramisphere	AUSTRALIA
CeramiSphere Pty Ltd	AUSTRALIA
Chalmers University of Technology	SWEDEN
Children's Cancer Institute Australia	AUSTRALIA
Clinpath Laboratories	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Daping Hospital	CHINA
Department of Surgery	UNITED STATES
Eurofins Panlabs	BELGIUM
Fermiscan Holdings Ltd.	AUSTRALIA
First Affiliated Hospital of Zhengzhou University	CHINA
Flinders University	AUSTRALIA
Georgia Institute of Technology	UNITED STATES
Ghent University	BELGIUM
Hanson Institute	AUSTRALIA
Harbin Institute of Technology	CHINA
Helmholtz Institute for Pharmaceutical Research Saarland	GERMANY
Hong Kong Institute of Education	HONG KONG
Hudson Institute of Medical Research	AUSTRALIA
Imperial College of Science, Technology and Medicine	UNITED KINGDOM
Institut Charles Gerhardt Montpellier	FRANCE
Jadavpur University	INDIA
Johnson & Johnson	UNITED STATES
Macquarie University	AUSTRALIA
Massey University	NEW ZEALAND
Max Planck Institute for Molecular Genetics	GERMANY
McGill University	CANADA
Memorial Sloan Kettering Cancer Centre	UNITED STATES
Micromyx	UNITED STATES
Monash University	AUSTRALIA
Murdoch University	AUSTRALIA
Naresuan University	THAILAND
Ohio State University	UNITED STATES
Oulu University	FINLAND
Oulun Yliopisto	FINLAND
pSiMedica Ltd	UNITED KINGDOM
pSivida Limited	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
RDC Clinical Pty Ltd	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Rush University	UNITED STATES
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
Starpharma	AUSTRALIA
Sung Kyun Kwan University	KOREA, REPUBLIC OF (SOUTH)
Swiss Federal Institute of Technology Zurich (ETH)	SWITZERLAND
The Hospital for Sick Children	UNITED STATES
The University of Wollongong	AUSTRALIA
Tianjin Hospital	CHINA
Umeå University	SWEDEN
University College Dublin	IRELAND
University of Adelaide	AUSTRALIA
University of Bristol	UNITED KINGDOM
University of California	UNITED STATES
University of Copenhagen	DENMARK
University of Ferrara	ITALY
University of Hamburg	GERMANY
University of Ljubljana	SLOVENIA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Bengal	INDIA
University of Nottingham	UNITED KINGDOM
University of Otago	NEW ZEALAND
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Tokyo	JAPAN
University of Toronto	CANADA
University of Warwick	UNITED KINGDOM
University of Western Australia	AUSTRALIA
University of Wisconsin-Madison	UNITED STATES
Uppsala Biomedicinska Centrum	SWEDEN
Uppsala University	SWEDEN
Victoria University	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Member Royal Australian Chemical Institute (RACI)	2017
Member Controlled Release Society	2017
Member American Association of Pharmaceutical Science (AAPS)	2017

Teaching & student supervision

Highlights

Drug delivery systems
Colloid Science

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
`Understanding the Role of Neurotrophins in the Pathogenesis of Alzheimer's Disease'.	Current
Characterizing the role of intestinal M cells in the transport of nanoparticles in an advanced microfluidic model of the small intestinal follicle-associated epithelium	Current
Functional antigen carrier particles for oral vaccination	Current
Lipid nanoparticle design for improved response to nucleic acid vaccines	Current
Mesoporous silica nanoparticle for the delivery of antibacterialdrugs to treat intracellular infection	Current
Polymeric micelles to improve the delivery of poorly soluble antimicrobial agents to bacterial and fungal biofilms	Current
Prodrugs and nanomedicines for oral chemotherapy	Current
Solid nanostructured carrier materials for the development of novel lipid-based systems for anti-psychotic drug delivery.	Current
Studying tumor development using Nanoscale sensor and actuator system	Current
A combined lipophilic prodrug and lipid-based drug delivery approach to enable oral chemotherapy (with SN38)	Completed
Cationic polymer mediated siRNA complexes: relationship between intracellular delivery and physicochemical properties	Completed
Combining porous nanostructure and lipid carriers to improve oral delivery systems for poorly water soluble drugs	Completed
Dendrimers interactions with lipid bilayers: mechanistic and kinetic studies	Completed
Designing nanostructured biomaterials with specific activities towards digestive enzymes for controlled lipid hydrolysis	Completed
Development of imaging methods/models to study oral vaccination and/or delivery of biologics	Completed
Improving nitric oxide delivery to staphylococcus aureus biofilms	Completed
Lipid liquid crystal nanostructures to enhance the delivery and efficacy of antimicrobials against bacterial biofilms	Completed
Lipoceramic microparticles for enhancing oral anticancer drug delivery	Completed
Liposome-micelle hybrid systems for oral delivery of poorly water-soluble cardiovascular drug lovastatin and anticancer drugs paclitaxel and 5-fluorouracil	Completed
Microfluidic intestine-on-a-chip in vitro models for improved mechanistic understanding of intestinal drug and particulate carrier uptake	Completed
Microfluidic intestine-on-a-chip in vitro models for improved understanding of intestinal particulate carrier absorption and interaction with mucus	Completed
Multi-compartmental emulsion systems for the oral delivery of subunit vaccines	Completed
Nanoparticle coated liposomes for encapsulation and delivery of proteins	Completed
Nanostructured clay materials for solidifying lipid-based drug delivery systems	Completed
Novel glyceryl monooleate (GMO) cubosomes stabilized using silica nanoparticles for the oral delivery of poorly water soluble drugs	Completed
Optimising the interfacial properties of porous silicon for effective control of molecular and biomolecular interactions	Completed
Optimizing silica encapsulated lipid-based oral drug delivery systems	Completed
Physicochemical and biopharmaceutical investigations of novel drug delivery systems for oral administration of poorly water-soluble drugs: Silica-lipid hybrid microcapsules	Completed
Polymer-lipid hybrid microparticles enhance the intracellular uptake and activity of rifampicin against bacterially infected macrophages	Completed
Porous silicon as a delivery system for poorly soluble drugs	Completed
Supersaturated silica-lipid hybrids - overcoming the challenges of oral drug delivery	Completed
The impact of formulating 5-Fluorouracil into liposomes on its site-specific delivery to tumour tissue	Completed

Professor Clive Prestidge

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UniSA Clinical & Health Sciences

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