Professor Cory Xian

Research Professor UniSA Clinical & Health Sciences

City West Campus (HB6-29)
tel +61 8 830 21944

email Cory.Xian@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

Cory is interested in tissue growth and injury repair research. He leads the Bone Growth and Repair Research Group at University of South Australia. He is established as a leading researcher in paediatric bone biology and cancer chemotherapy-induced bone defects. He has more than 170 publications (including journals: J Bone Miner Res, Endocr Rev, Endocrinology, Nat Rev Rheumatol, Hum Mol Genet, Am J Pathol, Am J Physiol Endocr Metab, PloS One, Bone, J Cell Physiol, and Sci Rep). Cory is Managing Editor for Frontiers in Bioscience, Guest Editor for Journal of Molecular Endocrinolology, Guest Editor for International Journal of Endocrinology, and is an editorial board member for 8 other journals including Scientific Reports.

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UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

Tweets by @UniversitySA

Research

Research focus

Clinical Sciences
Biochemistry and Cell Biology
Biological Sciences
Medical and Health Sciences
Neurosciences

Highlights

Cory has a long-standing track record in research on tissue growth, injury repair and roles of growth factors. Since 2002, he has focused his research on bone growth, injury and repair, an exciting area of paediatric bone biology that is relatively unexplored and yet scientifically challenging and clinically critically impacting on children’s bone growth, bone mass accumulation, and adult bone health. His group mainly focuses on the following three areas:

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2016	Cui, H, Li, T, Wang, L, Su, Y & Xian, C 2016, 'Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice', Scientific Reports, vol. 5, Article number 19185 , pp. 1-9. Open access 53 51 1
2016	Su, Y-W, Chung, R, Ruan, C-S, Chim, SM, Kuek, V, Dwivedi, PP, Mohammadhossein Hassanshahi , Chen, K-M, Xie, Y, Chen, L, Foster, BK, Rosen, V, Zhou, X-F, Xu, J & Xian, CJ 2016, 'Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats', Journal of Bone and Mineral Research, v. 31, no. 6, pp. 1258-1274. Open access 61 50

Chapters

Year	Output
2013	Chung, R & Xian, CJ 2013, 'Preclinical studies on growth plate cartilage regeneration using chondrocytes or mesenchymal stem cells', in MK Danquah & RI Mahato (eds), Emerging trends in cell and gene therapy, Humana Press, United States, ch. 25, pp. 625 - 636.
2013	Georgiou, KR & Xian, CJ 2013, 'Role of Wnt/β-catenin signaling in bone marrow adiposity following cancer chemotherapy', in Y Lin & X Cai (eds), Adipogenesis: signaling pathways, molecular regulation and impact on human disease, Nova Science Publishers Inc, US, ch. 4, pp. 109-126.
2012	Fan, C & Xian, CJ 2012, 'Potential protection of bone growth using folinic acid during paediatric cancer chemotherapy', in HS Watanabe (ed.), Horizons in cancer research, Nova Science Publishers, United States, vol. 48, pp. 111-123.
2012	Georgiou, KR & Xian, CJ 2012, 'Damage and recovery of the bone and bone marrow following methotrexate chemotherapy', in VS Castillo & LA Moyano (eds), Methotrexate: update on pharmacology, clinical applications and warnings, Nova Science Publishers, US, ch. 9, pp. 199-207.
2012	Xian, CJ & Shandala, T 2012, 'Roles of EGF family of growth factors in growth : overview of their roles in postnatal growth and development', in VR Preedy (ed.), Handbook of growth and growth monitoring in health and disease, Springer, New York, NY, ch. 170, pp. 2857-2870. 2
2010	Xian, CJ 2010, 'Mechanisms of bony repair at the injured growth plate cartilage', in V Legard & R Schluter (eds), Bone regeneration: growth factors, augmentation procedures and tissue engineering applications, Nova Science Publishers, Hauppauge, NY, ch. 9, pp. 263-273.

Journal Articles

Year	Output
2023	Jiang, T, Su, W, Li, Y, Jiang, M, Zhang, Y, Xian, CJ & Zhai, Y 2023, 'Research progress on nanomaterials for tissue engineering in oral diseases', Journal of Functional Biomaterials, vol. 14, no. 8, pp. 1-28. Open access 1
2023	Miao, L-W, Liu, T-Z, Sun, Y-H, Cai, N, Xuan, Y-Y, Wei, Z, Cui, B-B, Jing, L-L, Ma, H-P, Xian, CJ, Wang, J-F, Gao, Y-H & Chen, K-M 2023, 'Simulated microgravity-induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia', Journal of Cellular Physiology, vol. 238, no. 11, pp. 2692-2709. 5 1
2023	Su, YW, Lee, AM, Xu, X, Hua, B, Tapp, H, Wen, XS & Xian, CJ 2023, 'Methotrexate Chemotherapy Causes Growth Impairments, Vitamin D Deficiency, Bone Loss, and Altered Intestinal Metabolism-Effects of Calcitriol Supplementation', Cancers, vol. 15, no. 17, pp. 1-20. Open access 3
2023	Zhou, J, Ren, Xm, Wang, X, Li, Z & J Xian, C 2023, 'Recent advances and challenges of the use of the CRISPR/Cas system as a non-nucleic acid molecular diagnostic', Heliyon, vol. 9, no. 12, article no. E22767, pp. 1-17. Open access 2 1
2022	He, WF, Qin, R, Gao, YH, Zhou, J, Wei, JJ, Liu, J, Hou, XF, Ma, HP, Xian, CJ, Li, XY & Chen, KM 2022, 'The interdependent relationship between the nitric oxide signaling pathway and primary cilia in pulse electromagnetic field-stimulated osteoblastic differentiation', The FASEB Journal, vol. 36, no. 6, pp. 1-16. Open access 8 6 1
2022	Liu, J, Leng, FF, Gao, YH, He, WF, Wang, JF, Xian, CJ, Ma, HP & Chen, KM 2022, 'Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity', Journal of Cellular and Molecular Medicine, vol. 27, no. 1, pp. 36-51. Open access 6 1 2
2022	Patil, S, Hu, L, Zhu, C, Xian, CJ & Qian, A 2022, 'Editorial: Development, metabolism, senescence and mechanotransduction of bone', Frontiers in Cell and Developmental Biology, vol. 10, article no. 1103581, pp. 1-3. Open access 1
2022	Peymanfar, Y, Su, Y-W, Hassanshahi, M & Xian, CJ 2022, 'Methotrexate treatment suppresses osteoblastic differentiation by inducing Notch2 signaling and blockade of Notch2 rescues osteogenesis by preserving Wnt/β-catenin signaling', Journal of Orthopaedic Research, vol. 40, no. 10, pp. 2258-2270. Open access 2 3 1
2022	Peymanfar, Y, Su, YW & Xian, CJ 2022, 'Notch2 blockade mitigates methotrexate chemotherapy-induced bone loss and marrow adiposity', Cells, vol. 11, no. 9, pp. 1-21. Open access 7 8 2
2022	Yaser, P, Su, Y-W, Hassanshahi, M & Xian, CJ 2022, 'Therapeutic targeting notch2 protects bone micro-vasculatures from methotrexate chemotherapy-induced adverse effects in rats', Cells, vol. 11, no. 15, article no. 2382. Open access 1 2
2022	Zhang, Y, Liu, L, Pillman, KA, Hayball, J, Su, YW & Xian, CJ 2022, 'Differentially expressed miRNAs in bone after methotrexate treatment', Journal of Cellular Physiology, vol. 237, no. 1, pp. 965-982. Open access 3 5
2021	Fan, J, Su, YW, Hassanshahi, M, Chia-ming Fan, Peymanfar, Y, Piergentili, A, Del Bello, F, Quaglia, W & Xian, CJ 2021, 'β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats', Journal of Cellular Physiology, vol. 236, no. 5, pp. 3740-3751. Open access 4 4 1
2021	Jiang, H, Zhong, J, Li, W, Dong, J, Xian, CJ, Shen, YK, Yao, L, Wu, Q & Wang, L 2021, 'Gentiopicroside promotes the osteogenesis of bone mesenchymal stem cells by modulation of β-catenin-BMP2 signalling pathway', Journal of Cellular and Molecular Medicine, vol. 25 no. 23, pp. 10825-10836. Open access 12 11
2021	Lan, H, Huang, T, Xiao, J, Liao, Z, Ouyang, J, Dong, J, Xian, CJ, Hu, J, Wang, L, Ke, Y & Liao, H 2021, 'The immuno-reactivity of polypseudorotaxane functionalized magnetic CDMNP-PEG-CD nanoparticles', Journal of Cellular and Molecular Medicine, vol. 25, no. 1, pp. 561-574. Open access 9 8 1
2021	Su, YW, Fan, J, Fan, CM, Peymanfar, Y, Zhang, YL & Xian, CJ 2021, 'Roles of apoptotic chondrocyte-derived CXCL12 in the enhanced chondroclast recruitment following methotrexate and/or dexamethasone treatment', Journal of Cellular Physiology, vol. 236, no. 8, pp. 5966-5979. Open access 2 2
2021	Wei, L, Wen, XS & Xian, CJ 2021, 'Chemotherapy-induced intestinal microbiota dysbiosis impairs mucosal homeostasis by modulating toll-like receptor signaling pathways', International Journal of Molecular Sciences, vol. 22, no. 17, article no. 9474 pp. 1-17. Open access 53 47 1
2021	Yu-Wen, S, Wong, DS, Fan, J, Chung, R, Wang, L, Chen, Y, Xian, CH, Yao, L, Wang, L, Foster, BK, Xu, J & Xian, CJ 2021, 'Enhanced BMP signalling causes growth plate cartilage dysrepair in rats', Bone, vol. 145, pp. 1-13. 9 8 32
2021	Zhang, Y-L, Liu, L, Peymanfar, Y, Anderson, P & Xian, CJ 2021, 'Roles of microRNAs in osteogenesis or adipogenesis differentiation of bone marrow stromal progenitor cells', International Journal of Molecular Sciences, vol. 22, no. 13, article no. 7210, pp. 1-18. Open access 21 25
2021	Zhang, YL, Liu, L, Su, Y-W & Xian, CJ 2021, 'miR-542-3p attenuates bone loss and marrow adiposity following methotrexate treatment by targeting sFRP-1 and smurf2', International Journal of Molecular Sciences, vol. 22, no. 20, article no. 10988, pp. 1-19. Open access 6 7 1
2021	Zhang, YL, Liu, L, Su, YW & Xian, CJ 2021, 'miR-6315 attenuates methotrexate treatment-induced decreased osteogenesis and increased adipogenesis potentially through modulating TGF-β/smad2 signalling', Biomedicines, vol. 9, no. 12, article no. 1926. Open access 3 5 1
2020	Che, H, Li, J, Li, Y, Ma, C, Liu, H, Qin, J, Dong, J, Zhang, Z, Xian, CJ, Miao, D, Wang, L & Ren, Y 2020, 'p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle', eLife, vol. 9, article no. e52570, pp. 1-23. Open access 116 118 1
2020	Dong, J, Jhu, R-J, Wang, L, Jiang, C-P & Xian, CJ 2020, 'A hybrid platform for three-dimensional printing of bone scaffold by combining thermal-extrusion and electrospinning methods', Microsystem Technologies: Micro and Nanosystems Information Storage and Processing Systems, vol. 26, no. 6, pp. 1847-1861. 7 6
2020	Wong, RH, Zaw, JJT, Xian, CJ & Howe, PR 2020, 'Regular supplementation with resveratrol improves bone mineral density in postmenopausal women: a randomised, placebo‐controlled trial', Journal of Bone and Mineral Research, vol. 35, no. 11, pp. 2121-2131. Open access 74 64 396
2020	Zhang, Q, Li, J, Li, Y, Che, H, Chen, Y, Dong, J, Xian, CJ, Miao, D, Wang, L & Ren, Y 2020, 'Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment', Journal of Cellular and Molecular Medicine, vol. 24, no. 16, pp. 8950-8961. Open access 16 15
2019	Cai, J, Huang, L, Huang, J, Kang, L, Lin, H, Huang, P, Zhu, P, Wang, J, Dong, J, Wang, L & Xian, CJ 2019, 'Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer', Journal of Cellular Biochemistry, vol. 120, no 4, pp. 4935-4941. Open access 19 14
2019	Chen, C, Dong, J, Chen, H, Wang, X, Mei, J, Wang, L & Xian, CJ 2019, 'Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells', Journal of Cellular Physiology, vol. 234, no. 7, pp. 10771-10781. 9 8
2019	Hassanshahi, A, Hassanshahi, M, Khabbazi, S, Hosseini-Khah, Z, Peymanfar, Y, Qhalamkari, S, Su, YW & Xian, CJ 2019, 'Adipose-derived stem cells for wound healing', Journal of Cellular Physiology, vol. 234, no. 6, pp. 7903-7914. Open access 128 118 1
2019	Hassanshahi, M, Hassanshahi, A, Khabbazi, S, Su, YW & Xian, CJ 2019, 'Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow', Critical Reviews in Oncology Hematology, vol. 137, pp. 43-56. Open access 15 14
2019	Hassanshahi, M, Khabbazi, S, Peymanfar, Y, Hassanshahi, A, Hosseini-Khah, Z, Su, Y-W & Xian, CJ 2019, 'Critical limb ischemia: Current and novel therapeutic strategies', Journal of Cellular Physiology, vol. 234, no. 9, pp. 14445-14459. Open access 20 17 2
2019	Hassanshahi, M, Su, YW, Fan, CM, Khabbazi, S, Hassanshahi, A & Xian, CJ 2019, 'Methotrexate chemotherapy-induced damages in bone marrow sinusoids: An in vivo and in vitro study', Journal of Cellular Biochemistry, vol. 120, no. 3, pp. 3220-3231. 13 14
2019	Hassanshahi, M, Su, YW, Khabbazi, S, Fan, CM, Chen, KM, Wang, JF, Qian, A, Howe, PR, Yan, DW, Zhou, HD & Xian, CJ 2019, 'Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats', Journal of Cellular Physiology, vol. 234, no. 7, pp. 11276-11286. Open access 10 10
2019	Hassanshahi, M, Su, YW, Khabbazi, S, Fan, CM, Tang, Q, Wen, X, Fan, J, Chen, KM & Xian, CJ 2019, 'Icariin attenuates methotrexate chemotherapy-induced bone marrow microvascular damage and bone loss in rats', Journal of Cellular Physiology, vol. 234, no. 9, pp.16549-16561. 7 8
2019	Hu, J, Shi, D, Ding, M, Huang, T, Gu, R, Xiao, J, Xian, CJ, Dong, J, Wang, L & Liao, H 2019, 'Calmodulin-dependent signalling pathways are activated and mediate the acute inflammatory response of injured skeletal muscle', The Journal of Physiology, vol. 597, no. 21, pp. 5161-5177. Open access 16 18 3
2019	Khabbazi, S, Hassanshahi, M, Hassanshahi, A, Peymanfar, Y, Su, Y-W & Xian, CJ 2019, 'Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression', Naunyn-Schmiedebergs Archives of Pharmacology, vol. 392, no. 2, pp. 123-133. Open access 13 16
2019	Lee, AM, Bowen, JM, Su, Y-W, Plews, E, Chung, R, Keefe, DM & Xian, CJ 2019, 'Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats', Journal of Cellular Biochemistry, vol. 120, no. 3, pp. 4180-4191. Open access 4 3 1
2019	Liu, X, Cui, H, Niu, H, Wang, L, Li, X, Sun, J, Wei, Q, Dong, J, Liu, L & Xian, CJ 2019, 'Hydrocortisone suppresses early paraneoplastic inflammation and angiogenesis to attenuate early hepatocellular carcinoma progression in rats', OncoTargets and Therapy, vol. 12, pp. 9481-9493. Open access 7 5
2019	Luo, P, Dong, J, Qi, J, Zhang, Y, Liu, X, Zhong, Y, Xian, CJ & Wang, L 2019, 'An enhanced staining method K-B-2R staining for three-dimensional nerve reconstruction', BMC Neuroscience, vol. 20, no. 1, article no. 32, pp. 1-16. Open access 1 1 1
2019	Tang, Q, Su, YW, Fan, CM, Chung, R, Hassanshahi, M, Peymanfar, Y & Xian, CJ 2019, 'Release of CXCL12 from apoptotic skeletal cells contributes to bone growth defects following dexamethasone therapy in rats', Journal of Bone and Mineral Research, vol. 34, no. 2, pp. 310-326. Open access 6 6 15
2019	Wang, L, Dong, J & Xian, CJ 2019, 'Computational modeling of bone cells and their biomechanical behaviors in responses to mechanical stimuli', Critical Reviews in Eukaryotic Gene Expression, vol. 29, no. 1, pp. 51-67. 5 5
2019	Wang, Y-Y, Pu, XY, Shi, W-G, Fang, Q-Q, Chen, X-R, Xi, H-R, Gao, Y-H, Zhou, J, Xian, CJ & Chen, K-M 2019, 'Pulsed electromagnetic fields promote bone formation by activating the sAC-cAMP-PKA-CREB signaling pathway', Journal of Cellular Physiology, vol. 234, no. 3, pp. 2807-2821. 34 23 4
2019	Zhang, X, Zhang, Y, Fan, J, Yuan, F, Tang, Q & Xian, CJ 2019, 'Analyses of fracture line distribution in intra-articular distal radius fractures', Radiologia Medica, vol. 124, no. 7, pp. 613-619. Open access 14 14
2019	Zhou, J, Gao, Y-H, Zhu, B-Y, Shao, J-L, Ma, H-P, Xian, CJ & Chen, K-M 2019, 'Sinusoidal electromagnetic fields increase peak bone mass in rats by activating Wnt10b/β-Catenin in primary cilia of osteoblasts', Journal of Bone and Mineral Research, vol. 34, no. 7, pp.1336-1351. Open access 35 30 10
2018	Fan, CM, Su, YW, Howe, PR & Xian, CJ 2018, 'Long chain omega-3 polyunsaturated fatty acid supplementation protects against adriamycin and cyclophosphamide chemotherapy-induced bone marrow damage in female rats', International Journal of Molecular Sciences, vol. 19, no. 2, pp. 1-15. Open access 7 4
2018	Guo, Y, Wang, L-P, Li, C, Xiong, Y-X, Yan, Y-T, Zhao, L-Q, Li, S-D, Sun, J, Luo, H-Y & Xian, CJ 2018, 'Effects of ginsenoside Rb1 on expressions of phosphorylation Akt/phosphorylation mTOR/phosphorylation PTEN in artificial abnormal hippocampal microenvironment in rats', Neurochemical Research, vol. 43, no. 10, pp. 1927-1937. 20 16
2018	Hu, L, Su, P, Yin, C, Zhang, Y, Li, R, Yan, K, Chen, Z, Li, D, Zhang, G, Wang, L, Miao, Z, Qian, A & Xian, CJ 2018, 'Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis', Journal of Cellular Physiology, vol. 233, no. 2, pp. 1574-1584. 46 42
2018	Huang, L, Lin, H, Kang, L, Huang, P, Huang, J, Cai, J, Xian, Z, Zhu, P, Huang, M, Wang, L, Xian, CJ, Wang, J & Dong, J 2018, 'Aberrant expression of long noncoding RNA SNHG15 correlates with liver metastasis and poor survival in colorectal cancer', Journal of Cellular Physiology, online, pp. 1-8. 47 49 1
2018	Jiang, H, Chen, Y, Chen, G, Tian, X, Tang, J, Luo, L, Huang, M, Yan, B, Ao, X, Zhou, W, Wang, L, Bai, X, Zhang, Z, Wang, L & Xian, CJ 2018, 'Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling', Journal of Cellular Physiology, vol. 233, no. 2, pp. 117-1028. Open access 39 36 1
2018	Jiang, Z, Derrick-Roberts, AL, Jackson, MR, Rossouw, C, Pyragius, CE, Xian, C, Fletcher, J & Byers, S 2018, 'Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice', Molecular Genetics and Metabolism, vol. 124, no. 2, pp. 135-142. Open access 12 12 1
2018	Li, WY, Li, XY, Tian, YH, Chen, XR, Zhou, J, Zhu, BY, Xi, HR, Gao, YH, Xian, CJ & Chen, K-M 2018, 'Pulsed electromagnetic fields prevented the decrease of bone formation in hindlimb-suspended rats by activating sAC/cAMP/PKA/CREB signaling pathway', Bioelectromagnetics, vol. 39, no. 8, pp. 569-584. Open access 12 11 1
2018	Lin, C, Shao, Y, Zeng, C, Zhao, C, Fang, H, Wang, L, Pan, J, Liu, L, Qi, W, Feng, X, Qiu, H, Zhang, H, Chen, Y, Wang, H, Cai, D & Xian, CJ 2018, 'Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post-traumatic osteoarthritis', Journal of Cellular Physiology, vol. 233, no. 8, pp. 6135-6147. Open access 82 74
2018	Lv, C, Shi, C, Li, L, Wen, X & Xian, CJ 2018, 'Chinese herbal medicines in the prevention and treatment of chemotherapy-induced nausea and vomiting', Current Opinion in Supportive and Palliative Care, vol. 12, no. 2, pp. 174-180. 18 17 1
2018	Qin, T, Huang, D, Liu, Z, Zhang, X, Jia, Y, Xian, CJ & Li, K 2018, 'Tumor necrosis factor superfamily 15 promotes lymphatic metastasis via upregulation of vascular endothelial growth factor-C in a mouse model of lung cancer', Cancer Science, vol. 109, no. 8, pp. 2469-2478. Open access 18 17
2018	Su, Y-W, Zhou, X-F, Foster, BK, Grills, BL, Xu, J & Xian, CJ 2018, 'Roles of neurotrophins in skeletal tissue formation and healing', Journal of Cellular Physiology, vol. 233, no. 3, pp. 2133-2145. Open access 50 43
2018	Su, YW, Chim, SM, Zhou, L, Hassanshahi, M, Chung, R, Fan, C, Song, Y, Foster, BK, Prestidge, CA, Peymanfar, Y, Tang, Q, Butler, LM, Gronthos, S, Chen, D, Xie, Y, Chen, L, Zhou, XF, Xu, J & Xian, CJ 2018, 'Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats', Bone, vol. 116, pp. 232-247. Open access 17 15 1
2018	Sun, J, Cui, H, Gao, Y, Pan, Y, Zhou, K, Huang, J, Lan, J, Wei, Q, Liu, X, Liu, L & Xian, CJ 2018, 'TGF-a overexpression in breast cancer bone metastasis and primary lesions and TGF-a enhancement of expression of procancer metastasis cytokines in bone marrow mesenchymal stem cells', BioMed Research International, vol. 2018, article no. 6565393, pp. 1-10. Open access 18 16 3
2018	Teng, Z, Xie, X, Zhu, Y, Liu, J, Hu, X, Na, Q, Zhang, X, Wei, G, Xu, S, Liu, Y, Zhang, X & Xian, CJ 2018, 'miR-142-5p in bone marrow-derived mesenchymal stem cells promotes osteoporosis involving targeting adhesion molecule VCAM-1 and inhibiting cell migration', BioMed Research International, vol. 2018, article no. 3274641, pp. 1-7. Open access 17 18 1
2018	Wang, L, Dong, J & Xian, CJ 2018, 'Computational investigation on the biomechanical responses of the osteocytes to the compressive stimulus: a poroelastic model', BioMed Research International, vol. 2018, article id 4071356, pp. 1-16. Open access 13 9
2018	Wang, S, Li, J, Tian, J, Yu, Z, Gao, K, Shao, J, Li, A, Xing, S, Dong, Y, Li, Z, Gao, Y, Wang, L & Xian, CJ 2018, 'High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF-kappa B p65 pathway', Journal of Cellular Physiology, vol. 233, no. 9, pp. 7206-7216. Open access 20 17
2018	Wei, G, Wang, L, Dong, D, Teng, Z, Shi, Z, Wang, K, An, G, Guan, Y, Han, B, Yao, M & Xian, CJ 2018, 'Promotion of cell growth and adhesion of a peptide hydrogel scaffold via mTOR/cadherin signaling', Journal of Cellular Physiology, vol. 233, no. 2, pp. 822-829. Open access 11 10
2018	Xi, HR, Ma, HP, Yang, FF, Gao, YH, Zhou, J, Wang, YY, Li, WY, Xian, CJ & Chen, KM 2018, 'Total flavonoid extract of Epimedium herb increases the peak bone mass of young rats involving enhanced activation of the AC10/cAMP/PKA/CREB pathway', Journal of Ethnopharmacology, vol. 223, pp. 76-87. 26 25
2018	Yan, B, Huang, M, Zeng, C, Yao, N, Zhang, J, Yan, B, Jiang, H, Tian, X, Ao, X, Zhao, H, Zhou, W, Chu, J, Wang, L, Xian, CJ, Zhang, Z & Wang, L 2018, 'Locally produced IGF-1 promotes hypertrophy of the ligamentum flavum via the mTORC1 signaling pathway', Cellular Physiology and Biochemistry, vol. 48, no. 1, pp. 293-303. Open access 12 13
2018	Yin, C, Zhang, Y, Hu, L, Tian, Y, Chen, Z, Li, D, Zhao, F, Su, P, Ma, X, Zhang, G, Miao, Z, Wang, L, Qian, A & Xian, CJ 2018, 'Mechanical unloading reduces microtubule actin crosslinking factor 1 expression to inhibit β-catenin signaling and osteoblast proliferation', Journal of Cellular Physiology, vol. 233, no. 7, pp. 5405-5419. Open access 36 34
2018	Zhai, Y, Wang, Q, Li, Y, Cui, J, Feng, K, Kong, X & Xian, CJ 2018, 'The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K/Akt axis', Biomedicine and Pharmacotherapy, vol. 102, pp. 1015-1024. 25 23
2018	Zhang, X, Zhu, Y, Zhang, C, Liu, J, Sun, T, Li, D, Na, Q, Xian, CJ, Wang, L & Teng, Z 2018, 'miR-542-3p prevents ovariectomy-induced osteoporosis in rats via targeting SFRP1', Journal of Cellular Physiology, vol. 233, no. 9, pp.6798-6806. Open access 52 52 1
2018	Zhang, Y, Yin, C, Hu, L, Chen, Z, Zhao, F, Li, D, Ma, J, Ma, X, Su, P, Qiu, W, Yang, C, Wang, P, Li, S, Zhang, G, Wang, L, Qian, A & Xian, CJ 2018, 'MACF1 Overexpression by Transfecting the 21 kbp Large Plasmid PEGFP-C1A-ACF7 Promotes Osteoblast Differentiation and Bone Formation', Human Gene Therapy, vol. 29, no. 2, pp. 259-270. 19 19
2018	Zhu, B, Yang, Z, Chen, X, Zhou, J, Gao, Y, Xian, C & Chen, K 2018, 'Exposure duration Is a determinant of the effect of sinusoidal electromagnetic fields on peak bone mass of young rats', Calcified Tissue International, vol. 103, no. 1, pp. 95-106. Open access 9 7
2017	Bin, X, Lin, C, Huang, X, Zhou, Q, Wang, L & Xian, CJ 2017, 'FGF-2 gene polymorphism in osteoporosis among Guangxi's Zhuang Chinese', International Journal of Molecular Sciences, vol. 18, no. 7, article no. 1358, pp. 1-13. Open access 7 6
2017	Fan, C, Georgiou, KR, Morris, HA, McKinnon, RA, Keefe, DM, Howe, PR & Xian, CJ 2017, 'Combination breast cancer chemotherapy with doxorubicin and cyclophosphamide damages bone and bone marrow in a female rat model', Breast Cancer Research and Treatment, vol. 165, no. 1, pp. 41-51. 36 32 2
2017	Fan, J, Mei, J, Zhang, M-Z, Yuan, F, Li, S-Z, Yu, G-R, Chen, LH, Tang, Q & Xian, CJ 2017, 'Clinicopathological significance of glucose transporter protein-1 overexpression in human osteosarcoma', Oncology Letters, vol. 14, no. 2, pp. 2439-2445. Open access 12 11
2017	Fan, J, Yuan, F, Li, SZ, Qian Tang & Xian, CJ 2017, 'Is the preoperative closed reduction irreplaceable for distal radius fracture surgical treatment? - a retrospective clinical study', International Journal of Clinical and Experimental Medicine, vol. 10, no. 1, pp. 1309-1314. Open access 3 2
2017	Hassanshahi, M, Hassanshahi, A, Khabbazi, S, Su, Y-W & Xian, CJ 2017, 'Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy', Angiogenesis, vol. 20, no. 4, pp. 427-442. Open access 38 37 1
2017	Kaisang, L, Siyu, W, Lijun, F, Daoyan, P, Xian, CJ & Jie, S 2017, 'Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing', Journal of Surgical Research, vol. 217, pp. 63-74. Open access 87 87 4
2017	Lee, AM, Shandala, T, Soo, PP, Su, Y-W, King, TJ, Chen, K-M, Howe, PR & Xian, CJ 2017, 'Effects of resveratrol supplementation on methotrexate chemotherapy‐induced bone loss', Nutrients, vol 9. no. 3, article no. 255, pp. 1-15. Open access 23 16 15
2017	Ma, X-N, Ma, C-X, Shi, W-G, Zhou, J, Ma, H-P, Gao, Y-H, Xian, C & Chen, K-M 2017, 'Primary cilium is required for the stimulating effect of icaritin on osteogenic differentiation and mineralization of osteoblasts in vitro', Journal of Endocrinological Investigation, online, pp. 1-10. Open access 8 7
2017	Mellati, A, Fan, C-M, Tamayol, A, Annabi, N, Dai, S, Bi, J, Jin, B, Xian, CJ, Khademhosseini, A & Zhang, H 2017, 'Microengineered 3D cell-laden thermoresponsive hydrogels for mimicking cell morphology and orientation in cartilage tissue engineering', Biotechnology and Bioengineering, vol. 114, no. 1, pp. 217-231. Open access 67 61
2017	Shi, W, Gao, Y, Wang, Y, Zhou, J, Wei, Z, Ma, X, Ma, H, Xian, CJ, Wang, J & Chen, K 2017, 'The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts', Journal of Biological Chemistry, vol. 291, no. 51, pp. 20883-20896. Open access 58 54 1
2017	Shi, W, Xie, Y, He, J, Zhou, J, Gao, Y, Wei, W, Ding, N, Ma, H, Xian, CJ, Chen, K & Wang, J 2017, 'Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia', Scientific Reports, vol. 7, article no. 1866, pp. 1-12. Open access 46 42 1
2017	Su, Y-W, Chen, K-M, Mohammadhossein Hassanshahi , Qian Tang, Howe, PR & Xian, CJ 2017, 'Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals', Annals of the New York Academy of Sciences, vol. 1403, pp. 109-117. Open access 19 16 1
2016	Cai, Z, Li, Z, Dong, J, Mao, Z, Wang, L & Xian, CJ 2016, 'A study on protective performance of bullet-proof helmet under impact loading', Journal of Vibroengineering, vol.18, no. 4, pp. 2495-2507. Open access 17 11
2016	Cai, Z, Li, Z, Wang, L, Hsu, H, Xiao, Z & Xian, CJ 2016, 'A three-dimensional finite element modelling of human chest injury following front or side impact loading', Journal of Vibroengineering, vol. 18, no. 1, pp. 539-550. Open access 12 9
2016	Cui, H, Li, T, Wang, L, Su, Y & Xian, C 2016, 'Dioscorea bulbifera polysaccharide and cyclophosphamide combination enhances anti-cervical cancer effect and attenuates immunosuppression and oxidative stress in mice', Scientific Reports, vol. 5, Article number 19185 , pp. 1-9. Open access 53 51 1
2016	Fan, C-m, Georgiou, K, McKinnon, R, Keefe, D, Howe, P & Xian, C 2016, 'Combination chemotherapy with cyclophosphamide, epirubicin and 5-fluorouracil causes trabecular bone loss, bone marrow cell depletion and marrow adiposity in female rats', Journal of Bone and Mineral Metabolism, vol. 34, no. 3, pp. 277-290. Open access 29 28
2016	Hao, J, Gu, F, Zhu, J, Lu, S, Liu, Y, Li, Y, Chen, W, Wang, L, Fan, S & Xian, CJ 2016, 'Low night temperature affects the phloem ultrastructure of lateral branches and raffinose family oligosaccharide (RFO) accumulation in RFO-transporting plant melon (Cucumismelo L.) during fruit expansion', PLoS One, vol. 11, no. 8, pp. 1-15. Open access 20 17 2
2016	Shi, C-j, Wen, X-s, Gao, H-f, Liu, Z-h, Xu, X-k, Li, L-f, Shen, T & Xian, CJ 2016, 'Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats', Journal of Ethnopharmacology, vol. 183, pp. 143-150. Open access 26 22 1
2016	Su, Y-W, Chung, R, Ruan, C-S, Chim, SM, Kuek, V, Dwivedi, PP, Mohammadhossein Hassanshahi , Chen, K-M, Xie, Y, Chen, L, Foster, BK, Rosen, V, Zhou, X-F, Xu, J & Xian, CJ 2016, 'Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats', Journal of Bone and Mineral Research, v. 31, no. 6, pp. 1258-1274. Open access 61 50
2016	Wang, G, Wang, J, Sun, D, Xin, J, Wang, L, Huang, D, Wu, W & Xian, CJ 2016, 'Short-term hypoxia accelerates bone loss in ovariectomized rats by suppressing osteoblastogenesis but enhancing osteoclastogenesis', Medical Science Monitor: International Medical Journal for Clinical and Experimental Research, vol. 22, pp. 2961-2971. Open access 25 25 1
2016	Wang, L & Xian, CJ 2016, 'Dynamic analyses of osteoblast vibrational responses: a finite element viscoelastic model', Journal of Vibroengineering, vol. 18, no. 7, pp. 4605-4616. Open access 6 5
2016	Wang, L, Hsu, H-Y, Li, X & Xian, CJ 2016, 'Effects of frequency and acceleration amplitude on osteoblast mechanical vibration responses: a finite element study', BioMed Research International, vol. 2016, article no. 2735091, pp. 1-16. Open access 20 11
2016	Xie, Y, Yi, L, Weng, T, Huang, J, Luo, F, Jiang, W, Xian, CJ, Du, X & Chen, L 2016, 'Fibroblast growth factor receptor 3 deficiency does not impair the osteoanabolic action of parathyroid hormone on mice', International Journal of Biological Sciences, vol. 12, no. 8, pp. 990-999. Open access 7 5
2016	Xie, Y-F, Shi, W-G, Zhou, J, Gao, Y-h, Li, S-F, Fang, Q-Q, Wang, M-G, Ma, H-P, Wang, J-F, Xian, CJ & Chen, K-M 2016, 'Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium', Bone, vol. 93, pp. 22-32. Open access 66 56 1
2016	Yang, L, Wang, L, Wang, X, Xian, CJ & Lu, H 2016, 'A possible role of intestinal microbiota in the pathogenesis of ankylosing spondylitis', International Journal of Molecular Sciences, vol. 17, no. 12, article no. 2126, pp. 1-17. Open access 47 42 31
2016	Zhou, J, Ma, X-N, Gao, Y-h, Yan, J-L, Shi, W-G, Xian, CJ & Chen, K-M 2016, 'Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro', Electromagnetic Biology and Medicine, vol. 35, no. 1, pp. 75-83. Open access 14 11
2015	Cui, H, Yang, M, Wang, L & Xian, C 2015, 'Identification of a new marine bacterial strain SD8 and optimization of Its culture conditions for producing alkaline protease', PLoS One, vol. 10, no. 12, article no. e0146067, pp. 1-13. Open access 15 11 1
2015	Gao, H, Wen, X & Xian, C 2015, 'Hydroxymethyl furfural in Chinese herbal medicines: Its formation, presence, metabolism, bioactivities and implications', African Journal of Traditional, Complementary and Alternative Medicines, vol. 12, no. 2, pp. 43-54. Open access 15 11 3
2015	Georgiou, KR, Raghu, NR, Fan, C-m & Xian, CJ 2015, 'Methotrexate-induced bone marrow adiposity is mitigated by folinic acid supplementation through the regulation of Wnt/β-Catenin signalling', Journal of Cellular Physiology, vol. 230, no. 3, pp. 648-656. Open access 18 15
2015	King, TJ, Shandala, T, Lee, A, Foster, B, Chen, K, Howe, P & Xian, C 2015, 'Potential effects of phytoestrogen genistein in modulating acute methotrexate chemotherapy-induced osteoclastogenesis and bone damage in rats', International Journal of Molecular Sciences, vol. 16, no. 8, pp. 18293-18311. Open access 5 22
2015	Wang, L, Dong, J & Xian, CJ 2015, 'Strain amplification analysis of an osteocyte under static and cyclic loading : a finite element study', BioMed Research International, vol. 2015, article no. 376474, pp. 1-14. Open access 31 34
2015	Yan, J-L, Zhou, J, Ma, H-P, Ma, X-N, Gao, Y-h, Shi, W-G, Fang, Q-Q, Ren, Q, Xian, CJ & Chen, KM 2015, 'Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia', Molecular and Cellular Endocrinology, vol. 404, pp. 132-140. Open access 57 51
2015	Zhang, L, Ge, S, Liu, H, Wang, Q, Wang, L & Xian, CJ 2015, 'Contact damage failure analyses of fretting wear behavior of the metal stem titanium alloy-bone cement interface', Journal of The Mechanical Behavior of Biomedical Materials, vol. 51, pp. 132-146. Open access 13 12
2015	Zhong, Y, Wang, L, Dong, J, Zhang, Y, Luo, P, Qi, J, Liu, X & Xian, CJ 2015, 'Three-dimensional Reconstruction of Peripheral Nerve Internal Fascicular Groups', Scientific Reports, vol. 5, pp. 1-13. Open access 25 22 7
2015	Zhou, FH-h, Yu, Y, Zhou, X-F & Xian, CJ 2015, 'Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats', Bone, vol. 73, pp. 24-31. Open access 4 4 4
2015	Zhou, J, Chen, K-M, Zhi, D-J, Xie, Q-J, Xian, CJ & Li, H-Y 2015, 'Effects of pyrite bioleaching solution of Acidithiobacillus ferrooxidans on viability, differentiation and mineralization potentials of rat osteoblasts', Archives of Pharmacal Research, vol. 38, no. 12, pp. 2228-2240. Open access 7 7
2014	Chim, SM, Kuek, V, Chow, ST, Lim, BS, Tickner, J, Zhao, J, Chung, R, Yu-Wen, S, Zhang, G, Erber, W, Xian, CJ, Rosen, V & Xu, J 2014, 'EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades', Journal of Cellular Physiology, vol. 230, no. 1, pp. 82-94. Open access 42 43 2
2014	Chung, R & Xian, CJ 2014, 'Recent research on the growth plate: mechanisms for growth plate injury repair and potential cell-based therapies for regeneration', Journal of Molecular Endocrinology, vol. 53, no. 1, pp. T45-T61. Open access 52 36 1
2014	Chung, R, Foster, B & Xian, CJ 2014, 'The potential role of VEGF-induced vascularisation in the bony repair of injured growth plate', Journal of Endocrinology, vol. 221, no. 1, pp. 63-75. Open access 33 27
2014	Fan, C, Garcia, M, Scherer, M, Tran, C & Xian, CJ 2014, 'Potential roles of metallothioneins I and II in protecting bone growth following acute methotrexate chemotherapy', Journal of Chemotherapy, vol. 26, no. 1, pp. 37-48. Open access 1 2
2014	Lee, AM, Morrison, JL, Botting, KJ, Shandala, T & Xian, CJ 2014, 'Effects of maternal hypoxia during pregnancy on bone development in offspring : a guinea pig model', International Journal of Endocrinology, vol. 2014, article no. 916918, pp. 1-12. Open access 8 8 1
2014	Lee, AM, Shandala, T, Nguyen, L, Muhlhausler, BS, Chen, K-M, Howe, PR & Xian, CJ 2014, 'Effects of resveratrol supplementation on bone growth in young rats and microarchitecture and remodeling in ageing rats', Nutrients, vol. 6, no. 12, pp. 5871-5887. Open access 10 36 1
2014	Ma, H, Ma, X-N, Ge, BF, Zhou, J, Gao, Y-h, Xian, C & Cheng, K 2014, 'Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potential in vitro', Cell Proliferation: in Basic and Clinical Sciences, vol. 47, no. 6, pp. 527-539. Open access 67 60 1
2014	Xiang, R, Lee, AM, Eindorf, T, Javadmanesh, A, Ghanipoor-Samami, M, Gugger, M, Fitzsimmons, CJ, Kruk, ZA, Pitchford, WS, Leviton, AJ, Thomsen, DA, Beckman, I, Anderson, G I, Burns, BM, Rutley, DL, Xian, CJ & Hiendleder, S 2014, 'Widespread differential maternal and paternal genome effects on fetal bone phenotype at mid-gestation', Journal of Bone and Mineral Research, vol. 29, no. 1, pp. 2392-2404. Open access 9 7 2
2014	Zhai, Y-K, Guo, X-Y, Ge, B-F, Zhen, P, Ma, X-N, Zhou, J, Ma, H-P, Xian, CJ & Chen, K-M 2014, 'Icariin stimulates the osteogenic differentiation of rat bone marrow stromal cells via activating the PI3K-AKT-eNOS-NO-cGMP-PKG', Bone, vol. 66, pp. 189-198. Open access 108 101 1
2014	Zhai, Y-K, Pan, Y-L, Niu, Y-B, Li, C-R, Wu, X-L, Fan, W-T, Lu, T-L, Mei, Q-B & Xian, CJ 2014, 'The importance of the prenyl group in the activities of osthole in enhancing bone formation and inhibiting bone resorption in vitro', International Journal of Endocrinology, vol. 2014, article no. 921954, pp. 1-16. Open access 35 33
2014	Zhou, J, Wang, J-Q, Ge, B-F, Ma, X-N, Ma, H-P, Xian, CJ & Chen, K-M 2014, 'Different electromagnetic field waveforms have different effects on proliferation, differentiation and mineralization of osteoblasts in vitro', Bioelectromagnetics, vol. 35, no. 1, pp. 30-40. Open access 37 33 5
2013	Chung, R, Foster, BK & Xian, CJ 2013, 'Inhibition of protein kinase-D promotes cartilage repair at injured growth plate in rats', Injury: International Journal of the Care of the Injured, vol. 44, no. 7, pp. 914-922. Open access 12 9
2013	Chung, R, Wong, D, Macsai, C, Piergentili, A, Del, BF, Quaglia, W & Xian, CJ 2013, 'Roles of Wnt/β-catenin signalling pathway in the bony repair of injured growth plate cartilage in young rats', Bone, vol. 52, no. 2, pp. 651-658. Open access 35 31
2013	Dwivedi, PP, Grose, RH, Filmus, J, Hii, CS, Xian, CJ, Anderson, PJ & Powell, BC 2013, 'Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3', Bone, vol. 55 no. 2, pp. 367-376. Open access 43 42
2013	Ma, X-N, Zhou, J, Ge, B-F, Zhen, P, Ma, H-P, Shi, W-G, Cheng, K, Xian, CJ & Chen, K-M 2013, 'Icariin induces osteoblast differentiation and mineralization without dexamethasone in vitro', Planta Medica: Natural Products and Medicinal Plant Research, vol. 79, no. 16, pp. 1501-1508. Open access 35 32
2013	Ming, L-G, Chen, K-M & Xian, CJ 2013, 'Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodelling', Journal of Cellular Physiology, vol. 228, no. 3, pp. 513-521. 198 172
2013	Ming, LG, Lv, X, Ma, X-N, Ge, BF, Zhen, P, Song, P, Zhou, J, Ma, HP, Xian, CJ & Chen, KM 2013, 'The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro', Endocrinology, vol. 154, no. 3, pp. 1202-1214. Open access 46 41
2013	Raghu Nadhanan, R, Fan, C-M, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone', Journal of Orthopaedic Research, vol. 32, no. 4, pp. 587-596. Open access 6 13
2013	Raghu, NR, Skinner, J, Chung, R, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats', PLoS One, vol. 8, no. 8, article no. e71592, pp. 1-12. Open access 16 28
2013	Shan, PF, Xian, CJ, Li, M, Xiang, GD & Yuan, LQ 2013, 'Osteoporosis', International Journal of Endocrinology, vol. 2013, article no. 952858, pp. 1-2. Open access 5 22
2012	Du, X, Xie, Y, Xian, CJ & Chen, L 2012, 'Role of FGFs/FGFRs in skeletal development and bone regeneration', Journal of Cellular Physiology, vol. 227, no. 12, pp. 3731-3743. 130 87
2012	Fan, C-M, Foster, BK, Hui, SK & Xian, CJ 2012, 'Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate', PLoS One, vol. 7, no. 10, article no. e46915, pp. 1-12. Open access 44 37
2012	Fong, L, Muhlhausler, BS, Gibson, RA & Xian, CJ 2012, 'Perinatal maternal dietary supplementation of ω3-fatty acids transiently affects bone marrow microenvironment, osteoblast and osteoclast formation, and bone mass in male offspring', Endocrinology, vol. 153, no. 5, pp. 2455-2465. Open access 25 24
2012	Georgiou, KR, Hui, S & Xian, CJ 2012, 'Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy', American Journal of Stem Cells, vol. 1, no. 3, pp. 205-224. Open access
2012	Georgiou, KR, King, TJ, Scherer, MA, Zhou, H, Foster, B & Xian, CJ 2012, 'Attenuated Wnt/ß-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats', Bone, vol. 50, no. 6, pp. 1223-1233. 54 53
2012	Georgiou, KR, Scherer, MA, Fan, C, Cool, J, King, TJ, Foster, B & Xian, CJ 2012, 'Methotrexate chemotherapy reduces osteogenesis but increases adipogenic potential in the bone marrow', Journal of Cellular Physiology, vol. 227, no. 3, pp. 909-918. 76 72
2012	Georgiou, KR, Scherer, MA, King, TJ, Foster, B & Xian, CJ 2012, 'Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy-induced damage and recovery of the bone marrow microenvironment', International Journal of Experimental Pathology, vol. 93, no. 2, pp. 104-114. Open access 19 16
2012	Hui, SK, Sharkey, L, Kidder, LS, Zhang, Y, Fairchild, G, Coghill, K, Xian, CJ & Yee, D 2012, 'The influence of therapeutic radiation on the patterns of bone marrow in ovary-intact and ovariectomized mice', PLoS One, vol. 7, no. 8, article no. e42668, pp. 1-9. Open access 25 25
2012	Jin, M, Yu, Y, Qi, H, Xie, Y, Su, N, Wang, X, Tan, Q, Luo, F, Zhu, Y, Wang, Q, Du, X, Xian, CJ, Liu, P, Huang, H, Shen, Y, Deng, C-X, Chen, D & Chen, L 2012, 'A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia', Human Molecular Genetics, vol. 21, no. 26, pp. 5443́<U+0093>5455. Open access 41 40
2012	King, TJ, Georgiou, KR, Cool, J, Scherer, M, Ang, E, Foster, B, Xu, J & Xian, CJ 2012, 'Methotrexate chemotherapy promotes osteoclast formation in the long bone of rats via increased pro-inflammatory cytokines and enhanced NF-kB activation', American Journal of Pathology, vol. 181, no. 1, pp. 121-129. 51 48
2012	Macsai, CE, Georgiou, KR, Foster, BK, Zannettino, AC & Xian, CJ 2012, 'Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair', Bone, vol. 50, no. 5, pp. 1081-1091. 50 44
2012	Raghu, NR, Abimosleh, SM, Su, Y-W, Scherer, MA, Howarth, GS & Xian, CJ 2012, 'Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss', American Journal of Physiology: Endocrinology and Metabolism, vol. 302, no. 11, pp. 1440-1449. Open access 36 37
2012	Shandala, T, Ng, YS, Hopwood, B, Yip, YC, Foster, B & Xian, CJ 2012, 'The role of osteocyte apoptosis in cancer chemotherapy-induced bone loss', Journal of Cellular Physiology, vol. 227, no. 1, pp. 2889-2897. 42 37
2012	Shen, Z, Bi, J, Shi, B, Nguyen, D, Xian, CJ, Zhang, H & Dai, S 2012, 'Exploring thermal reversible hydrogels for stem cell expansion in three-dimensions', Soft Matter, vol. 8, no. 27, pp. 7250-7257. 31 29
2012	Xie, Y, Su, N, Jin, M, Qi, H, Yang, J, Li, C, Du, X, Luo, F, Chen, B, Shen, Y, Huang, H, Xian, CJ, Deng, C-X & Chen, L 2012, 'Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia', Human Molecular Genetics, vol. 21, no. 18, pp. 3941-3955. Open access 41 39
2011	Chung, R, Foster, BK & Xian, CJ 2011, 'Injury responses and repair mechanisms of the injured growth plate', Frontiers in Bioscience (Scholar Edition), vol. 1, no. 3, pp. 117-125. Open access 30
2011	Chung, R, Foster, BK & Xian, CJ 2011, 'Preclinical studies on mesenchymal stem cell-based therapy for growth plate cartilage injury repair', Stem Cells International, vol. 2011, article no. 570125, pp. 1-10. Open access 28 26
2011	Fan, C, Foster, B, Wallace, W & Xian, C 2011, 'Pathobiology and prevention of cancer chemotherapy-induced bone growth arrest, bone loss, and osteonecrosis', Current Molecular Medicine, vol. 11, no. 2, pp. 140-151. 37 34
2011	Ma, H-P, Ming, L-G, Ge, B-F, Zhai, Y-K, Song, P, Xian, CJ & Chen, K-M 2011, 'Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro', Journal of Cellular Biochemistry, vol. 112, no. 3, pp. 916-923. 146 130
2011	Macsai, C, Hopwood, B, Chung, R, Foster, B & Xian, C 2011, 'Structural and molecular analyses of bone bridge formation within the growth plate injury site and cartilage degeneration at the adjacent uninjured area', Bone, vol. 49, no. 4, pp. 904-912. 24 22
2011	Muhlhausler, BS, Miljkovic, D, Fong, L, Xian, CJ, Duthoit, E & Gibson, RA 2011, 'Maternal omega-3 supplementation increases fat mass in male and female rat offspring', Frontiers in Genetics, vol. 2, no. 48, pp. 1-10. Open access 31
2011	Tran, C, Cool, J & Xian, CJ 2011, 'Dietary zinc and metallothionein on small intestinal disaccharidases activity in mice', World Journal of Gastroenterology, vol. 17, no. 3, pp. 354-360. Open access 9 8
2011	Xian, CJ, Fan, C, Georgiou, KR & King, TJ 2011, 'Methotrexate toxicity in growing long bones of young rats : a model for studying cancer chemotherapy-induced bone growth defects in children', BioMed Research International, vol. 2011, article no. 903097 pp. 1-8. Open access 40 33
2011	Zhou, J, Ming, L-G, Ge, BF, Wang, J-Q, Zhu, R-Q, Wei, Z, Ma, H-P, Xian, CJ & Chen, K-M 2011, 'Effects of 50 Hz sinusoidal electromagnetic fields of different intensities on proliferation, differentiation and mineralization potentials of rat osteoblasts', Bone, vol. 49, no. 4, pp. 753-761. 82 69
2010	McCarty, R, Xian, CJ, Gronthos, S, Zannettino, A & Foster, B 2010, 'Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury', The Open Orthopaedics Journal, vol. 4, pp. 204-210. Open access
2010	Xian, CJ, Georgiou, K & Foster, BK 2010, 'Damage and recovery of the Bone Marrow Microenvironment Induced by Cancer Chemotherapy-Potential Regulatory Role of Chemokine CXCL12/Receptor CXCR4 Signalling', Current Molecular Medicine, vol. 10, no. 5, pp. 440-453. 46 41
2009	Chung, R, Foster, B, Zannettino, AC & Xian, CJ 2009, 'Potential roles of growth factor PDGF-BB in the bony repair of injured growth plate', Bone, vol. 44, no. 5, pp. 878-885. 58 53
2009	Fan, C, Cool, JC, Scherer, MA, Foster, BK, Shandala, T, Tapp, H & Xian, CJ 2009, 'Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment', Bone, vol. 44, no. 1, pp. 61-70. 69 60
2009	Fong, L, Tan, K, Tran, C, Cool, J, Scherer, MA, Elovaris, R, Coyle, P, Foster, BK, Rofe, A & Xian, CJ 2009, 'Interaction of dietary zinc and intracellular binding protein metallothionein in postnatal bone growth', Bone, vol. 44, no. 6, pp. 1151-1162. 49 45
2009	Gronthos, S, McCarty, R, Mrozik, K, Fitter, S, Paton, S, Menicanin, D, Itescu, S, Bartold, PM, Xian, C & Zannettino, AC 2009, 'Heat shock protein-90 beta is expressed at the surface of multipotential mesenchymal precursor cells: generation of a novel monoclonal antibody, STRO-4, with specificity for mesenchymal precursor cells from human and ovine tissues', Stem Cells and Development, vol. 18, no. 9, pp. 1253-1262. 71 62
2009	Li, L, Li, F, Xian, CJ, Luo, XG, Zhou, X-F, Zhong, J & Song, X-Y 2009, 'Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - Possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor', European Journal of Neuroscience.
2009	McCarty, RC, Gronthos, S, Zannettino, AC, Foster, BK & Xian, CJ 2009, 'Characterisation and developmental potential of ovine bone marrow derived mesenchymal stem cells', Journal of Cellular Physiology, vol. 219, no. 2, pp. 324-333. 134 118
2009	Xian, CJ & Zhou, X-F 2009, 'Treating skeletal pain: limitations of conventional anti-inflammatory drugs, and anti-neurotrophic factor as a possible alternative', Nature Reviews Rheumatology, vol. 5, no. 2, pp. 92-98. 25 22
2008	Xian, CJ, Cool, JC, Scherer, MA, Chia-ming Fan & Foster, BK 2008, 'Folinic acid attenuates methotrexate chemotherapy-induced damages on bone growth mechanisms and pools of bone marrow stromal cells', Journal of Cellular Physiology, vol. 214, no. 3, pp. 777-785. 46 41
2008	Xian, CJ, Macsai, C & Foster, B 2008, 'Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair', Journal of Cellular Physiology.

Conferences

Year	Output
2021	Samarasinghe, C, Uddin, M, Bari, S & Xian, C 2021, 'Temperature and force generation in surgical bone drilling', 13th International Conference on Mechanical Engineering, ICME 2019, American Institute of Physics, vol. 2324, article no. 060007, pp. 1-8. 2 1
2020	Samarasinghe, C, Uddin, M, Bari, S & Xian, C 2020, 'Surgical bone drilling: a review', ASME 2019 International Mechanical Engineering Congress and Exposition, American Society of Mechanical Engineers, pp. 1-8. 1
2016	Wang, L-p, Hsu, H-y & Xian, CJ 2016, 'Vibration analyses of a single osteoblast in vitro using the finite element method', International Conference on Biomedical and Biological Engineering 2016 (BBE 2016), Atlantis Press, pp. 380-385. Open access

Research

Current research & highlights

(1) Mechanisms of normal bone growth and regulation: We are interested in understanding the mechanisms for the normal bone growth and currently we are focusing on understanding the growth plate biology and regulation of bone lengthening. We are also investigating whether some micro-nutrients can be used to positively modulate bone growth, bone mass accumulation, populations of skeletal stem cells, and adult bone health outcomes (such as osteoporosis and fractures).

(2) Mechanisms for growth plate trauma injury-induced growth defects: Growth plate trauma injury is a common and significant problem as 20% childhood bone fractures involve growth plate and the inured growth plate cartilage is often undesirably repaired by bony tissue leading to growth defects. Cory's group has been investigating cellular and molecular mechanisms for the faulty repair and developing growth factor- and/or stem cell- based repair.

(3) Mechanisms for and prevention of cancer chemotherapy-induced growth defects: While chemotherapy-based cancer treatment is becoming more successful and thus the use of chemotherapy is becoming more intensified, chemotherapy-induced long-term side effects are becoming more obvious as it stunts the bone growth and causes osteoporosis and frequent bone fractures which persists into adulthood. Cory's group is investigating the underlying cellular and molecular mechanisms for the bone growth defects and regeneration potentials of bone and bone marrow. This group also aims to develop supplementary preventative treatment that will preserve bone growth during chemotherapy.

External engagement & recognition

Collaborations

Highlights

Cory serves as editorial board members for eight international scientific journals.
Cory is a member of more than 10 biomedical and clinical research professional societies.

External engagement & recognition

Collaborations

Organisation	Country
940th Hospital of Joint Logistic Support Force, People's Liberation Army of China	CHINA
Academy of Orthopaedics of Guangdong Province	CHINA
Affiliated Hospital of Hebei University of Engineering	CHINA
Affiliated Huaian Hospital of Xuzhou Medical University	CHINA
Beijing Agricultural Technology Extension Centre	CHINA
Central South University	CHINA
China Agricultural University	CHINA
China University of Mining and Technology	CHINA
Chinese Academy of Agricultural Sciences	CHINA
Chinese Academy of Sciences	CHINA
Chongqing University of Science and Technology	CHINA
Daping Hospital	CHINA
Emu Tracks Australasia Pty Ltd	AUSTRALIA
Ferris State University	UNITED STATES
First Affiliated Hospital of Harbin Medical University	CHINA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Guangdong Food and Drug Vocational-technical School	CHINA
Guangdong General Hospital	CHINA
Guangdong University of Technology	CHINA
Guangxi Medical University	CHINA
Guangzhou University of Chinese Medicine	CHINA
Harbin Medical University	CHINA
Harvard University	UNITED STATES
Henan University	CHINA
Hong Kong Baptist University	HONG KONG
Hunan University of Science and Technology	CHINA
Institute of Medical and Veterinary Science	AUSTRALIA
Islamic Azad University	IRAN
Islamic Azad University Shahrekord Branch	IRAN
Jiangsu Province Hospital	CHINA
Jinan University (China)	CHINA
Kunming Medical University	CHINA
La Trobe University	AUSTRALIA
Lanzhou Command of CPLA	CHINA
Lanzhou General Hospital	CHINA
Lanzhou University	CHINA
Lanzhou University of Technology	CHINA
Luoyang Orthopedic Hospital of Henan Province	CHINA
Macau University of Science and Technology	MACAU (SAR OF CHINA)
Mazandaran University of Medical Sciences	IRAN
Nanjing Medical University	CHINA
National Formosa University	TAIWAN
National Institutes of Health	MALAYSIA
National Taipei University of Technology	TAIWAN
Ningbo No.6 Hospital	CHINA
Ningbo University	CHINA
Ningxia Medical College	CHINA
North-Eastern University	THAILAND
Northwest A&F University	CHINA
Northwestern Polytechnical University	CHINA
Orthopedic Institute of Henan Province	UNITED STATES
Peking Union Medical College Hospital	CHINA
Provincial People's Hospital	CHINA
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Hospital for Sick Children	UNITED KINGDOM
Rush University	UNITED STATES
SA Pathology	AUSTRALIA
Second People's Hospital of Pingxiang	CHINA
Second Xiangya Hospital of Central-South University	CHINA
Shandong University	CHINA
Shanghai Jiao Tong University	CHINA
Shanxi Medical University	CHINA
Shenyang Agricultural University	CHINA
Shenzhen People's Hospital	CHINA
Shenzhen Sixth People's Hospital, China	CHINA
Shenzhen University	CHINA
Shiraz University Of Medical Sciences	IRAN
South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC)	AUSTRALIA
Southern Medical University	CHINA
Sun Yat-Sen University	CHINA
Taipei Medical University	TAIWAN
Third Affiliated Hospital of Southern Medical University	CHINA
Third Military Medical University	CHINA
Tianjin Hospital	CHINA
Tianjin Medical University	CHINA
Tongji University	CHINA
Università degli Studi di Camerino	ITALY
Universita' di Camerino	ITALY
University of Adelaide	AUSTRALIA
University of Chinese Medicine	CHINA
University of Melbourne	AUSTRALIA
University of Minnesota, Twin Cities	UNITED STATES
University of Newcastle	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Southern Queensland	AUSTRALIA
University of Sydney	AUSTRALIA
University of Toronto	CANADA
University of Western Australia	AUSTRALIA
Wenzhou Medical University	CHINA
Women's and Children's Health Network	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
Wuhan General Hospital of Guangzhou Military	CHINA
Xi'an Medical University	CHINA
Xuzhou Clinical College of Nanjing Medical University	CHINA
Yanshan University	CHINA
Youjiang Medical University for Nationalities	CHINA
Yue Bei People's Hospital	CHINA
Zhejiang University College of Medicine	CHINA
Zhengzhou University	CHINA

External engagement & recognition

Engagement/recognition	Year
Editorial Board Member Scientific Reports (Nature Publishing Group)	2018
Member Channel-7 Children's Research Foundation Research Committee	2018
Member Bone Health Foundation Research Committee	2018
Member Channel-7 Children's Research Foundation Research Committee	2017
Member Bone Health Foundation Research Committee	2017
Project Grant: NT-3 as an upstream and potentially master regulator promoting bone fracture healing National Health and Medical Research Council (NHMRC)	2017
Project Grant National Health and Medical Research Council (NHMRC)	2016
Research Fellowship National Health and Medical Research Council (NHMRC)	2013
Senior Research Fellowship National Health and Medical Research Council (NHMRC)	2008

Teaching & student supervision

Highlights

Supervising research programs of Honours, Master and PhD students
Supervising research programs of research assistants, postdoctoral fellows and visiting scholars
Delivering guest lectures to biomedical science and biotechnology students at both University of South Australia and University of Adelaide.

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Characterization of proBDNF knock out mice and effect of proBDNF on angiogenesis	Completed
Developing a systemic monoclonal antibody therapy for the treatment of large burn injuries	Completed
Pathophysiology of bone marrow micro-vascular system damage and potency of flavonoids in recovery of bone marrow micro-vasculature following methotrexate therapy in rats	Completed
Potential function of neurotrophic factors in growth plate cartilage bony repair and skeletal cell formation	Completed
Potential protective effects of supplementation with nutraceuticals in preventing chemotherapy-induced bone loss in rats	Completed
Potential regulatory roles of miRNA(s) in bone loss and marrow adiposity following methotrexate treatment in rats	Completed
Roles of bone morphogenetic protein signalling in the bony repair of injured growth plate cartilage in young rats	Completed
Roles of chemokine CXCL12 in bone growth defects induced by methotrexate and dexamethasone chemotherapeutic treatment	Completed
Roles of Notch2 signalling pathway in bone & bone marrow micro-vasculature damage following methotrexate chemotherapy in rats	Completed
Teaching an old dog new tricks: a global approach to enhancing the cytotoxicity of drug-loaded, non-responsive micelles using oligoelectrolytes	Completed
The effect of different degrees of loading on the biomechanical responses of bone cells: understanding the role of mechanical stimuli on functional behaviour of bone	Completed
The 'not-so-sweet' effects of maternal sweetened beverage consumption during pregnancy and lactation on metabolic outcomes in the adult rat and her offspring	Completed

Professor Cory Xian

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Highlights

Chapters

Journal Articles

Conferences

Current research & highlights

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Editorial Board Member

Member

Member

Member

Member

Project Grant: NT-3 as an upstream and potentially master regulator promoting bone fracture healing

Project Grant

Research Fellowship

Senior Research Fellowship

Teaching & student supervision

Highlights

Courses and programs

Research degree supervision

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