Dr Damon Tumes

Group Leader in Allergic Inflammation Centre for Cancer Biology

City West Campus (HB11-36)
tel +61 8 830 29016

email Damon.Tumes@unisa.edu.au

Research Degree Supervisor

About me

Damon is the head of the Allergy and Cancer Immunology laboratory in the Centre for Cancer Biology (CCB), a joint venture between UniSA and SA Pathology.

Damon received a Ph.D. in Immunology from the University of Adelaide in 2009 followed by post-doctoral studies at Chiba University Medical School, Japan where he was promoted to Assistant Professor in 2011 and Associate Professor in 2014. His main research interests are lymphocyte differentiation and immunological memory in the context of chronic allergic inflammation. He returned to Australia in 2015 and joined the new EMBL Australia Systems Immunology group at the South Australian Health and Medical Research Institute (SAHMRI) from 2015-2018 where he worked on immune system programming ... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Biochemistry and Cell Biology
Immunology
Medical and Health Sciences
Biological Sciences
Oncology and Carcinogenesis

Research

Projects

Excludes commercial-in-confidence projects.

Defining the therapeutic potential of eosinophils in melanoma, Australian Melanoma Research Foundation, 01/02/2025 - 31/01/2026

Other projects

Research themes and projects in the Allergy and Cancer Immunology Laboratory (Tumes Lab):

Epigenetic regulation of Th2 cells in chronic allergic inflammation

Almost every cell in an individual has identical DNA yet can differentiate into all of the specialized cells of the body. This is accomplished via epigenetic regulation of gene expression. Our laboratory investigates how allergy associated T cells called Th2 cells are epigenetically programmed to drive diseases including asthma and chronic rhinosinusitis. Gata3 is a key driver of Th2 cell differentiation, and we have defined an intronic enhancer region of the Gata3 gene that is very important for epigenetic programming of Th2 cells. This project will extend these findings to determine how epigenetic regulation of Gata3 occurs in CD4 T cells using in vitro models of Th2 cell differentiation, 3D analysis of chromatin conformation, and newly developed in vivo asthma models.

Defining inflammatory networks and granulocyte heterogeneity in severe asthma

Severe asthma affects one in six asthmatics, yet this cohort comprises more than half of the $28 b/year asthma cost to Australia as these patients have a higher risk of life-threatening asthma attacks, poorer quality of life and progressive non-reversible loss of airway function. This project will 1) use spatial transcriptomics and computational analysis of cell-cell signalling networks to define inflammatory networks underlying severe steroid resistant airway inflammation and 2) use single cell RNA-Sequencing and proteomics to define new granulocyte subsets in the airways of humans with asthma. Until recently, eosinophils were viewed as homogenous effector cells that attack parasitic worms and viruses and often underlie chronic asthma. We have defined several new subsets of eosinophils in the airways of patients with chronic rhinosinusitis and asthma and this project will determine their functions and the potential to target them to treat severe airway disease.

Hijacking allergic inflammation to treat cancer

Groundbreaking discoveries in immunotherapy, such as inhibition of checkpoint receptors on T cells and chimeric antigen receptor (CAR) T cells have provided new hope in the war against cancer. Allergic inflammation manifests as strong aberrant responses to antigens in the environment; however, how these pathways intersect with cancer remains poorly understood. We have shown that polarisation of CD4 T cells to produce allergy driving cytokines results in enhanced ability to kill established lymphomas. This exciting finding shows that it may be possible to harness the strong pathophysiological mechanisms that normally drive allergic inflammation to treat cancer. This project will define how we can enhance T cell function in cancer and how the effector granulocytes (e.g. eosinophils, mast cells and basophils) that normally drive allergy can be manipulated to abolish solid tumors.

Deciphering epithelial programming events that potentiate development of asthma

Respiratory infections in early life are strongly associated with asthma development yet the mechanisms are unknown. This project uses in vitro 3D tissue organoid differentiation models and analysis of airway tissue from humans to determine how the airway epithelium is epigenetically programmed during differentiation and during early life.

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2024	Wang, H, Yip, KH, Keam, SP, Vlahos, R, Nichol, K, Wark, P, Toubia, J, Kral, AC, Cildir, G, Pant, H, Hercus, TR, Wilson, N, Owczarek, C, Lopez, AF, Bozinovski, S & Tumes, DJ 2024, 'Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade', Journal of Allergy and Clinical Immunology, vol. 153, no. 3, pp. 672-683.e6. Open access 5 2 67
2022	Yip, KH, McKenzie, D, Ramshaw, HS, Chao, J, McClure, BJ, Pant, H, Grimbaldeston, MA, Hercus, TR, Lopez, AF & Tumes, DJ and 12 other authors 2022, 'Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model', Journal of Investigative Dermatology, vol. 142, no. 4, pp 1103-1113.e11. Open access 5 3 1
2018	Lynn, MA, Tumes, DJ, Choo, JM, Sribnaia, A, Blake, SJ, Leong, LEX, Young, GP, Marshall, HS, Wesselingh, SL, Rogers, GB & Lynn, DJ 2018, 'Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice', Cell Host and Microbe, vol. 23, no. 5, pp. 653-660.e5. Open access 148 137 104
2017	Tumes, DJ, Papadopoulos, M, Endo, Y, Onodera, A, Hirahara, K & Nakayama, T 2017, 'Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma', Immunological Reviews, vol. 278, no. 1, pp. 8-19. 77 70 1
2013	Tumes, DJ, Onodera, A, Suzuki, A, Shinoda, K, Endo, Y, Iwamura, C, Hosokawa, H, Koseki, H, Tokoyoda, K, Suzuki, Y, Motohashi, S & Nakayama, T 2013, 'The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells', Immunity. Open access 248 234

Chapters

Year	Output
2024	Pant, H, Morrow, R, Tumes, D & Seethala, R 2024, 'Pathology of Nasal Polyps', in Ö Önerci Celebi & T Metin Önerci (eds), Nasal polyposis and its management : pathogenesis, medical and surgical treatment, 2nd ed., Springer Nature, Switzerland, ch. 4, pp. 23-34.

Journal Articles

Year	Output
2025	Kan, WL, Weekley, CM, Nero, TL, Hercus, TR, Yip, KH, Tumes, DJ, Woodcock, JM, Ross, DM, Thomas, D, Terán, D, Owczarek, CM, Liu, NW, Martelotto, LG, Polo, JM, Pant, H, Tvorogov, D, Lopez, AF & Parker, MW 2025, 'The β common cytokine receptor family reveals new functional paradigms from structural complexities', Immunological Reviews, vol. 329, no. 1, pp. 1-25. Open access 1
2024	Aba, Ü, Maslak, İC, İpşir, C, Pehlivan, D, Warnock, N I, Tumes, DJ, Cildir, G & Erman, B 2024, 'A novel homozygous germline mutation in transferrin receptor 1 (TfR1) leads to combined immunodeficiency and provides new insights into iron-immunity axis', Journal of Clinical Immunology, vol. 44, no. 2, article no. 55, pp. 1-14. Open access 3 3 6
2024	Cildir, G, Aba, U, Pehlivan, D, Tvorogov, D, Warnock, N I, Kok, CH, Tumes, DJ & Erman, B and 17 other authors 2024, 'Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans', Nature Communications, vol. 15, no. 1, pp. 1-18. Open access 9
2024	Wallach, I, Bernard, D, Nguyen, K, Ho, G, Tumes, D, Cildir, G & Heifets, A and 680 other authors, all authors are part of the The Atomwise AIMS Program 2024, 'AI is a viable alternative to high throughput screening: a 318-target study', Scientific Reports, vol. 14, no. 1, pp. 1-16. Open access 29 80
2024	Wang, H, Yip, KH, Keam, SP, Vlahos, R, Nichol, K, Wark, P, Toubia, J, Kral, AC, Cildir, G, Pant, H, Hercus, TR, Wilson, N, Owczarek, C, Lopez, AF, Bozinovski, S & Tumes, DJ 2024, 'Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade', Journal of Allergy and Clinical Immunology, vol. 153, no. 3, pp. 672-683.e6. Open access 5 2 67
2023	Pant, H, Hercus, TR, Tumes, DJ, Yip, KH, Parker, MW, Owczarek, CM, Lopez, AF & Huston, DP 2023, 'Translating the biology of β common receptor-engaging cytokines into clinical medicine', Journal of Allergy and Clinical Immunology, vol. 151, no. 2, pp. 324-344. Open access 10 6 1
2023	Yip, KH, Chao, J, Coolen, C, Pant, H, Kral, A, Smith, W, Schwarz, Q, Grimbaldeston, MA, Pitson, S, Lopez, AF, Woodcock, J & Tumes, DJ 2023, 'IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ', Journal of Allergy and Clinical Immunology, vol. 152, no. 3, pp. 725-735. Open access 5 4 2
2022	Stevens, NE, van Wolfswinkel, M, Bao, W, Ryan, FJ, Brook, B, Amenyogbe, N, Marshall, HS, Lynn, MA, Kollmann, TR, Tumes, DJ & Lynn, DJ 2022, 'Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice', Vaccine, vol. 40, no. 11, pp. 1594-1605. 10 10 16
2022	Wang, H, Tumes, DJ, Hercus, TR, Yip, K, Aloe, C, Vlahos, R, Lopez, AF, Wilson, N, Owczarek, CM & Bozinovski, S 2022, 'Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models', Cell Death and Disease, vol. 13, no. 2, article no. 137, pp. 1-11. Open access 21 16 6
2022	Whyte, CE, Tumes, DJ, Liston, A & Burton, OT 2022, 'Do more with less: improving high parameter cytometry through overnight staining', Current Protocols, vol. 2, no. 11, article no. e589, pp. 1-20. Open access 17 15 194
2022	Yip, KH, McKenzie, D, Ramshaw, HS, Chao, J, McClure, BJ, Pant, H, Grimbaldeston, MA, Hercus, TR, Lopez, AF & Tumes, DJ and 12 other authors 2022, 'Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model', Journal of Investigative Dermatology, vol. 142, no. 4, pp 1103-1113.e11. Open access 5 3 1
2021	Blake, SJ, James, J, Ryan, FJ, Caparros-Martin, J, Eden, GL, Tee, YC, Salamon, JR, Benson, SC, Tumes, DJ, Sribnaia, A, Stevens, NE, Finnie, JW, Kobayashi, H, White, DL, Wesselingh, SL, O'Gara, F, Lynn, MA & Lynn, DJ 2021, 'The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota', Cell Reports Medicine, vol. 2, no. 12, article no. 100464, pp. 1-28. Open access 22 20 26
2021	Cildir, G & Tumes, DJ 2021, 'DOT1L leaves its mark on adaptive immunity', Immunology and Cell Biology, vol. 99, no. 4, pp. 348-350. Open access 6
2021	Cildir, G, Yip, KH, Pant, H, Tergaonkar, V, Lopez, AF & Tumes, DJ 2021, 'Understanding mast cell heterogeneity at single cell resolution', Trends in Immunology, vol. 42, no. 6, pp. 523-535. Open access 28 26 6
2021	De Silva, AP, Schembri, MA, Sarah, AH, Chao, J, Yip, KH, Cildir, G, Lopez, A, Tumes, DJ & Pant, H 2021, 'Short-term oral steroids significantly improves chronic rhinosinusitis without nasal polyps', The Laryngoscope, vol. 131, no. 10, pp. E2618-E2626. 5 5 3
2021	Nakajima, T, Kanno, T, Yokoyama, S, Sasamoto, S, Asou, HK, Tumes, DJ, Ohara, O, Nakayama, T & Endo, Y 2021, 'ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice', Journal of Experimental Medicine, vol. 218, no. 12, article no. e20210639. Open access 20 21 14
2021	Zadeh Shirazi, A, McDonnell, MD, Fornaciari, E, Bagherian, NS, Scheer, KG, Samuel, MS, Yaghoobi, M, Ormsby, RJ, Poonnoose, S, Tumes, DJ & Gomez, GA 2021, 'A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma', British Journal of Cancer, vol. 125, pp. 337-350. Open access 30 22 5
2020	Hojyo, S, Tumes, D, Murata, A & Tokoyoda, K 2020, 'Multiple developmental pathways lead to the generation of CD4 T-cell memory', International Immunology, vol. 32, no. 9, pp. 589-595. Open access 9 9 1
2020	Sarkander, J, Hojyo, S, Mursell, M, Yamasaki, Y, Wu, T-Y, Tumes, DJ, Miyauchi, K, Tran, CL, Zhu, J, Löhning, M, Hutloff, A, Mashreghi, M-F, Kubo, M, Radbruch, A & Tokoyoda, K 2020, 'Enhanced cell division is required for the generation of memory CD4 T cells to migrate into their proper location', Frontiers in Immunology, vol. 10, article no. 3113, pp. 1-12. Open access 1 2 8
2020	Suzuki, AS, Yagi, R, Kimura, MY, Iwamura, C, Shinoda, K, Onodera, A, Hirahara, K, Tumes, DJ, Koyama-Nasu, R, Iismaa, SE, Graham, RM, Motohashi, S & Nakayama, T 2020, 'Essential role for CD30-transglutaminase 2 axis in memory Th1 and Th17 cell generation', Frontiers in Immunology, vol. 11, article no. 1536, pp. 1-12. Open access 5 5 2
2020	Yip, KH, Wilson, NJ, Pant, H, Brown, CL, Busfield, S, Ng, M, Alhamdoosh, M, Woodman, N, Schembri, M, Tumes, DJ, Vairo, G, Lopez, AF, Nash, AD, Wilson, MJ, Grimbaldeston, MA & Owczarek, CM 2020, 'Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model', Allergy: European Journal of Allergy and Clinical Immunology, vol. 75, no. 2, pp. 475-478. 9 7 6
2019	Endo, Y, Onodera, A, Obata-Ninomiya, K, Koyama-Nasu, R, Asou, HK, Ito, T, Yamamoto, T, Kanno, T, Nakajima, T, Ishiwata, K, Kanuka, H, Tumes, DJ & Nakayama, T 2019, 'ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis', Nature Metabolism, vol. 1, no. 2, pp. 261-275. Open access 47 50 13
2019	Ichikawa, T, Hirahara, K, Kokubo, K, Kiuchi, M, Aoki, A, Morimoto, Y, Kumagai, J, Onodera, A, Mato, N, Tumes, DJ, Goto, Y, Hagiwara, K, Inagaki, Y, Sparwasser, T, Tobe, K & Nakayama, T 2019, 'CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells', Nature Immunology, vol. 20, no. 11, pp. 1469-1480. 92 85 27
2019	Tumes, D, Hirahara, K, Papadopoulos, M, Shinoda, K, Onodera, A, Kumagai, J, Yip, KH, Pant, H, Kokubo, K, Kiuchi, M, Aoki, A, Obata-Ninomiya, K, Tokoyoda, K, Endo, Y, Kimura, MY & Nakayama, T 2019, 'Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology', Journal of Allergy and Clinical Immunology, vol. 144, no. 2, pp. 549-560.e 10. Open access 27 23 3
2019	Yip, KH, Papadopoulos, M, Pant, H & Tumes, DJ 2019, 'The role of invariant T cells in inflammation of the skin and airways', Seminars in Immunopathology, vol. 41, no. 3, pp. 401-410. Open access 14 15 2
2018	Lynn, MA, Tumes, DJ, Choo, JM, Sribnaia, A, Blake, SJ, Leong, LEX, Young, GP, Marshall, HS, Wesselingh, SL, Rogers, GB & Lynn, DJ 2018, 'Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice', Cell Host and Microbe, vol. 23, no. 5, pp. 653-660.e5. Open access 148 137 104
2018	Yamamoto, T, Endo, Y, Onodera, A, Hirahara, K, Asou, HK, Nakajima, T, Kanno, T, Ouchi, Y, Uematsu, S, Nishimasu, H, Nureki, O, Tumes, DJ, Shimojo, N & Nakayama, T 2018, 'DUSP10 constrains innate IL-33-mediated cytokine production in ST2ʰᶦ memory-type pathogenic Th2 cells', Nature Communications, vol. 9, no. 1, article no. 4231, pp. 1-15. Open access 38 39 1
2017	Nakayama, T, Hirahara, K, Onodera, A, Endo, Y, Hosokawa, H, Shinoda, K, Tumes, DJ & Okamoto, Y 2017, 'Th2 cells in health and disease', Annual Review of Immunology, ch. 3, pp. 53-84. 302 272 13
2017	Tumes, DJ, Papadopoulos, M, Endo, Y, Onodera, A, Hirahara, K & Nakayama, T 2017, 'Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma', Immunological Reviews, vol. 278, no. 1, pp. 8-19. 77 70 1
2016	Angela, M, Endo, Y, Asou, HK, Yamamoto, T, Tumes, DJ, Tokuyama, H, Yokote, K & Nakayama, T 2016, 'Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells', Nature Communications, vol. 7, article no. 13683, pp. 1-15. Open access 191 179 5
2016	Hayashizaki, K, Kimura, MY, Tokoyoda, K, Hosokawa, H, Shinoda, K, Hirahara, K, Ichikawa, T, Onodera, A, Hanazawa, A, Iwamura, C, Kakuta, J, Muramoto, K, Motohashi, S, Tumes, DJ, Iinuma, T, Yamamoto, H, Ikehara, Y, Okamoto, Y & Nakayama, T 2016, 'Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation', Science Immunology, vol. 1, no. 3, article no. eaaf9154. 56 55 87
2016	Shinoda, K, Hirahara, K, Iinuma, T, Ichikawa, T, Suzuki, AS, Sugaya, K, Tumes, DJ, Yamamoto, H, Hara, T, Tani-ichi, S, Ikuta, K, Okamoto, Y & Nakayama, T 2016, 'Thy1+ IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation', Proceedings of the National Academy of Sciences of USA, vol. 113, no. 20, pp. E2842-E2851. Open access 105 93 2
2015	Endo, Y, Asou, HK, Matsugae, N, Hirahara, K, Shinoda, K, Tumes, DJ, Tokuyama, H, Yokote, K & Nakayama, T 2015, 'Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1', Cell Reports, vol. 12, no. 6, pp. 1042-1055. Open access 191 187 26
2015	Endo, Y, Hirahara, K, Iinuma, T, Shinoda, K, Tumes, DJ, Asou, HK, Matsugae, N, Obata-Ninomiya, K, Yamamoto, H, Motohashi, S, Oboki, K, Nakae, S, Saito, H, Okamoto, Y & Nakayama, T 2015, 'The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway', Immunity, vol. 42, no. 2, pp.294-308. Open access 199 173 3
2015	Hosokawa, H, Kato, M, Tohyama, H, Tamaki, Y, Endo, Y, Kimura, MY, Tumes, DJ, Motohashi, S, Matsumoto, M, Nakayama, K I, Tanaka, T & Nakayama, T 2015, 'Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells', Journal of Biological Chemistry, vol. 290, no. 21, pp. 13095-13103. Open access 29 28 2
2015	Onodera, A, Tumes, DJ, Watanabe, Y, Hirahara, K, Kaneda, A, Sugiyama, F, Suzuki, Y & Nakayama, T 2015, 'Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes', Molecular and Cellular Biology, vol. 35, no. 22, pp. 3841-3853. Open access 17 16
2014	Endo, Y, Hirahara, K, Yagi, R, Tumes, DJ & Nakayama, T 2014, 'Pathogenic memory type Th2 cells in allergic inflammation', Trends in Immunology, vol. 35, no. 2, pp. 69-78. 108 101
2014	Watanabe, Y, Onodera, A, Kanai, U, Ichikawa, T, Obata-Ninomiya, K, Wada, T, Kiuchi, M, Iwamura, C, Tumes, DJ, Shinoda, K, Yagi, R, Motohashi, S, Hirahara, K & Nakayama, T 2014, 'Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 35, pp. 12829-12834. Open access 17 13
2013	Hosokawa, H, Tanaka, T, Suzuki, Y, Iwamura, C, Ohkubo, S, Endoh, K, Kato, M, Endo, Y, Onodera, A, Tumes, DJ, Kanai, A, Sugano, S & Nakayama, T 2013, 'Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 12, pp. 4691-4696. Open access 69 64
2013	Tumes, DJ, Onodera, A, Suzuki, A, Shinoda, K, Endo, Y, Iwamura, C, Hosokawa, H, Koseki, H, Tokoyoda, K, Suzuki, Y, Motohashi, S & Nakayama, T 2013, 'The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells', Immunity. Open access 248 234
2012	Iwamura, C, Shinoda, K, Endo, Y, Watanabe, Y, Tumes, DJ, Motohashi, S, Kawahara, K, Kinjo, Y & Nakayama, T 2012, 'Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo', Proceedings of the National Academy of Sciences of USA, vol. 109, no. 42, pp. 16992-16997. Open access 23 25
2012	Kuwahara, M, Yamashita, M, Shinoda, K, Tofukuji, S, Onodera, A, Shinnakasu, R, Motohashi, S, Hosokawa, H, Tumes, D, Iwamura, C, Lefebvre, V & Nakayama, T 2012, 'The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation', Nature Immunology, vol. 13, no. 8, pp. 778-786. Open access 147 137
2012	Shinoda, K, Tokoyoda, K, Hanazawa, A, Hayashizaki, K, Zehentmeier, S, Hosokawa, H, Iwamura, C, Koseki, H, Tumes, DJ, Radbruch, A & Nakayama, T 2012, 'Type II membrane protein CD69 regulates the formation of resting T-helper memory', Proceedings of the National Academy of Sciences of USA, vol. 109, no. 19, pp. 7409-7414. Open access 102 99
2012	Yamashita, J, Iwamura, C, Mitsumori, K, Hosokawa, H, Sasaki, T, Takahashi, M, Tanaka, H, Kaneko, K, Hanazawa, A, Watanabe, Y, Shinoda, K, Tumes, D, Motohashi, S & Nakayama, T 2012, 'Murine Schnurri-2 controls natural killer cell function and lymphoma development', Leukemia and Lymphoma, vol. 53, no. 3, pp. 479-486. 3 4
2011	Endo, Y, Iwamura, C, Kuwahara, M, Suzuki, A, Sugaya, K, Tumes, DJ, Tokoyoda, K, Hosokawa, H, Yamashita, M & Nakayama, T 2011, 'Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3', Immunity, vol. 35, no. 5, pp. 733-745. Open access 100 94
2011	Kitajima, M, Ito, T, Tumes, DJ, Endo, Y, Onodera, A, Hashimoto, K, Motohashi, S, Yamashita, M, Nishimura, T, Ziegler, SF & Nakayama, T 2011, 'Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells', Cancer Research, vol. 71, no. 14, pp. 4790-4798. Open access 26 23
2010	Suzuki, A, Iwamura, C, Shinoda, K, Tumes, DJ, Kimura, MY, Hosokawa, H, Endo, Y, Horiuchi, S, Tokoyoda, K, Koseki, H, Yamashita, M & Nakayama, T 2010, 'Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung', Journal of Immunology, vol. 184, no. 8, pp. 4510-4520. Open access 19 16
2009	Tumes, DJ, Connolly, A & Dent, LA 2009, 'Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma', International Immunology, vol. 21, no. 6, pp. 633-644. Open access 21 17
2008	Giacomin, P, Cava, M, Tumes, D, Gauld, A, Iddawela, D, Mccoll, S, Parsons, J, Gordon, D & Dent, L 2008, 'Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis', Parasite Immunology, vol. 30, no. 8, pp. 435-445. 13 10
2008	Tumes, DJ, Wong, AC, Sewell, WA, McColl, SR, Connolly, A & Dent, LA 2008, 'Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice', Molecular Immunology, vol. 45, no. 13, pp. 3609-3617. 8 8

Research

Patents

Details	Registry	Status
Methods for treating inflammatory skin conditions Owczarek, Catherine; Lopez, Angel; Yip, Kwok Ho; Tumes, Damon	WO	Granted
Methods for treating or preventing acute respiratory distress syndrome Owczarek, Catherine; Campbell, Ian; Krstevski, Karolina; Bozinovski, Steven; Lopez, Angel; Tumes, Damon	World	Granted

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
AMED	JAPAN
Atomwise Inc.	UNITED STATES
Babraham Institute	UNITED KINGDOM
Benaroya Research Institute	UNITED STATES
Chiba Institute of Technology	JAPAN
Chiba University	JAPAN
Cleveland Clinic Foundation	UNITED STATES
Clinpath Pathology	AUSTRALIA
CSL Limited	AUSTRALIA
Curtin University	AUSTRALIA
Department of Primary Industries	AUSTRALIA
Deutsches Rheuma-Forschungszentrum	GERMANY
Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute	GERMANY
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
German Rheumatism Research Center	GERMANY
Hacettepe University	TURKEY
Hokkaido University	JAPAN
Islamic Azad University	IRAN
Japan Science and Technology Agency	JAPAN
Jichi Medical University	JAPAN
Jikei University School Of Medicine	JAPAN
Johannes Gutenberg University of Mainz	GERMANY
Kan Research Institute	JAPAN
Kanto Gakuen University	JAPAN
Kazusa DNA Research Institute	JAPAN
Kyoto University	JAPAN
Leibniz Institute	GERMANY
Mashhad University of Medical Sciences	IRAN
National Institute of Allergy and Infectious Diseases	UNITED STATES
National Institute of Infectious Diseases (NIID)	JAPAN
National Research Institute for Child Health and Development, Tokyo	JAPAN
Nihon Pharmaceutical Co Ltd	JAPAN
Research Center for Allergy and Immunology	JAPAN
Riken	JAPAN
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Victorian Eye and Ear Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Süleyman Demirel University	TURKEY
Taiho Pharmaceutical Co	UNITED STATES
Telethon Kids Institute	AUSTRALIA
Texas A and M University	UNITED STATES
Tokai University	JAPAN
Tottori University	JAPAN
University of Adelaide	AUSTRALIA
University of Applied Sciences Leiden	NETHERLANDS
University of British Columbia	CANADA
University of California	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Pittsburgh	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Tokyo	JAPAN
University of Toyama	JAPAN
University of Tsukuba	JAPAN
Victor Chang Cardiac Research Institute	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Invited Speaker Japanese Society for Immunology	2024
Senior Lecturer University of Adelaide	2024
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2024
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2024
Visiting Associate Professor School of Medicine, Chiba University, Japan	2024
Invited Speaker Japanese Society for Immunology	2023
Senior Lecturer University of Adelaide	2023
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2023
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2023
Visiting Associate Professor School of Medicine, Chiba University, Japan	2023
Editorial Board Member Communications Biology	2022
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2022
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2022
Visiting Associate Professor School of Medicine, Chiba University, Japan	2022
Editorial Board Member Communications Biology	2021
Invited Lecture - Mapping inflammatory networks in allergic airway disease Molecular and Biomedical Science Seminar Series, The University of Adelaide	2021
Invited Speaker Becton Dickinson ANZ Single Cell Multiomics meeting, 21st September 2021	2021
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2021
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2021
Visiting Associate Professor School of Medicine, Chiba University, Japan	2021
Editorial Board Member Communications Biology	2020
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2020
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2020
Visiting Associate Professor School of Medicine, Chiba University, Japan	2020
Editorial Board Member Communications Biology	2019
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2019
South Australia and Northern Territory Branch Councillor Australian and New Zealand Society for Immunology	2019
Visiting Associate Professor School of Medicine, Chiba University, Japan	2019
Associate Faculty Member F1000	2018
Grant Review Panel National Health and Medical Research Council (NHMRC)	2018
Guest Editor Clinical and Translational Immunology	2018
Invited Lecture - Early-life immune system programming by the microbiome and vaccines School of Medicine, Chiba University	2018
Member American Association of Immunologists (AAI)	2018
Member Australasian Society for Immunology (ASI)	2018
Member Japanese Society for Immunology (JSI)	2018
Reviewer Immunology and Cell Biology	2018
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2018
Visiting Associate Professor School of Medicine, Chiba University, Japan	2018
Invited expert panel member/speaker SciPubAllergies: nothing to sneeze at, Adelaide	2017
Member Japanese Society for Immunology (JSI)	2017
Member Australasian Society for Immunology (ASI)	2017
Member American Association of Immunologists (AAI)	2017
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2017
Visiting Associate Professor School of Medicine, Chiba University, Japan	2017
Invited conference presentation Epigenetics Consortium of South Australia, Adelaide	2016
Keynote speaker Australasian Society for Immunology (ASI), Adelaide Immunology Retreat, Australia	2016
Member Japanese Society for Immunology (JSI)	2016
Member American Association of Immunologists (AAI)	2016
Member Australasian Society for Immunology (ASI)	2016
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2016
Session Chair Australian Society for Medical Research South Australian Scientific Meeting Adelaide	2016
Visiting Associate Professor School of Medicine, Chiba University, Japan	2016
Invited conference presentation 17th Fenner Conference and 45th Annual Scientific Meeting, Australasian Society for Immunology, Canberra	2015
Invited speaker Departmental Seminar, School of Molecular and Biomedical Science, University of Adelaide	2015
Member Australasian Society for Immunology (ASI)	2015
Member American Association of Immunologists (AAI)	2015
Member Japanese Society for Immunology (JSI)	2015
Organising committee Australasian Society for Immunology (ASI), Adelaide Immunology Retreat, Australia	2015
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2015
Visiting Associate Professor School of Medicine, Chiba University, Japan	2015
Invited conference presentation 24th Kyoto T Cell Conference, Japan	2014
Invited conference presentation 3rd Chiba-Uppsala Academia Joint Workshop; Inflammation, Metabolic Diseases and Cancer, Japan	2014
Member American Association of Immunologists (AAI)	2014
Member Japanese Society for Immunology (JSI)	2014
Member Australasian Society for Immunology (ASI)	2014
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2014
Session Chair 3rd Chiba-Uppsala Academia Joint Workshop; Inflammation, Metabolic Diseases and Cancer, Japan	2014
Invited speaker Departmental Seminar, Protein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, England	2013
Invited to present report National News Broadcast, NHK, Japan	2013
Member American Association of Immunologists (AAI)	2013
Member Japanese Society for Immunology (JSI)	2013
Member Australasian Society for Immunology (ASI)	2013
Member Japanese Society for Immunology (JSI)	2012
Member Australasian Society for Immunology (ASI)	2012
Member Japanese Society for Immunology (JSI)	2011
Member Australasian Society for Immunology (ASI)	2011
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2011
Member Australasian Society for Immunology (ASI)	2010
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2010
EAACI Poster Presentation Award XXVI Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Goteborg, Sweden	2009
Member Australian Society for Medical Research (ASMR)	2009
Member Australasian Society for Immunology (ASI)	2009
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2009
Research Fellow Global Centre for Excellence (G-COE), Faculty of Medicine, Department of Immunology, Chiba University	2009
Adelaide branch co-organiser World Day of Immunology	2008
Member Australasian Society for Immunology (ASI)	2008
Member Australian Society for Medical Research (ASMR)	2008

Teaching & student supervision

Teaching strengths

Immunology
Genetics
Epigenetics

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Deciphering how airway epithelial programming and inflammation cause chronic allergic airways disease	Current
Elucidating the functions of novel genetic drivers of common inflammatory diseases	Current

Dr Damon Tumes

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Other projects

Outputs

Highlights

Chapters

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Invited Speaker

Senior Lecturer

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Invited Speaker

Senior Lecturer

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Editorial Board Member

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Editorial Board Member

Invited Lecture - Mapping inflammatory networks in allergic airway disease

Invited Speaker

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Editorial Board Member

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Editorial Board Member

Senior Research Fellow

South Australia and Northern Territory Branch Councillor

Visiting Associate Professor

Associate Faculty Member

Grant Review Panel

Guest Editor

Invited Lecture - Early-life immune system programming by the microbiome and vaccines

Member

Member

Member

Reviewer

Senior Research Fellow

Visiting Associate Professor

Invited expert panel member/speaker

Member

Member

Member

Senior Research Fellow

Visiting Associate Professor

Invited conference presentation

Keynote speaker

Member

Member

Member

Senior Research Fellow

Session Chair

Visiting Associate Professor

Invited conference presentation

Invited speaker

Member

Member

Member

Organising committee

Senior Research Fellow