Dr Damon Tumes

Group Leader in Allergic Inflammation Centre for Cancer Biology

City West Campus (HB11-36)
tel +61 8 830 29016

email Damon.Tumes@unisa.edu.au

Research Degree Supervisor

About me

Damon received a Ph.D. in Immunology from the University of Adelaide in 2009 followed by post-doctoral studies at Chiba University Medical School, Japan where he was promoted to Assistant Professor in 2011 and Associate Professor in 2014. His main research interests are lymphocyte differentiation and immunological memory in the context of chronic allergic inflammation. He returned to Australia in 2015 and joined the new EMBL Australia Systems Immunology group at the South Australian Health and Medical Research Institute (SAHMRI). Damon is now a lab head at the University of South Australia and SA Pathology Centre for Cancer Biology (CCB). At the CCB, he is continuing to study airway inflammation and also applying his experience working on... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research themes

Healthy futures

Research focus

Immunology
Biological Sciences
Medical Microbiology
Medical and Health Sciences
Microbiology

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2018	Lynn, MA, Tumes, DJ, Choo, JM, Sribnaia, A, Blake, SJ, Leong, LEX, Young, GP, Marshall, HS, Wesselingh, SL, Rogers, GB & Lynn, DJ 2018, 'Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice', Cell Host and Microbe, vol. 23, no. 5, pp. 653-660.e5. 27 18 87
2017	Tumes, DJ, Papadopoulos, M, Endo, Y, Onodera, A, Hirahara, K & Nakayama, T 2017, 'Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma', Immunological Reviews, vol. 278, no. 1, pp. 8-19. 26 21 1
2013	Tumes, DJ, Onodera, A, Suzuki, A, Shinoda, K, Endo, Y, Iwamura, C, Hosokawa, H, Koseki, H, Tokoyoda, K, Suzuki, Y, Motohashi, S & Nakayama, T 2013, 'The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells', Immunity. Open access 133 121 8

Journal Articles

Year	Output
2020	Sarkander, J, Hojyo, S, Mursell, M, Yamasaki, Y, Wu, T-Y, Tumes, DJ, Miyauchi, K, Tran, CL, Zhu, J, Löhning, M, Hutloff, A, Mashreghi, M-F, Kubo, M, Radbruch, A & Tokoyoda, K 2020, 'Enhanced cell division is required for the generation of memory CD4 T cells to migrate into their proper location', Frontiers in Immunology, vol. 10, article no. 3113, pp. 1-12. Open access 9
2020	Suzuki, AS, Yagi, R, Kimura, MY, Iwamura, C, Shinoda, K, Onodera, A, Hirahara, K, Tumes, DJ, Koyama-Nasu, R, Iismaa, SE, Graham, RM, Motohashi, S & Nakayama, T 2020, 'Essential role for CD30-transglutaminase 2 axis in memory Th1 and Th17 cell generation', Frontiers in Immunology, vol. 11, article no. 1536, pp. 1-12. Open access
2020	Yip, KH, Wilson, NJ, Pant, H, Brown, CL, Busfield, S, Ng, M, Alhamdoosh, M, Woodman, N, Schembri, M, Tumes, DJ, Vairo, G, Lopez, AF, Nash, AD, Wilson, MJ, Grimbaldeston, MA & Owczarek, CM 2020, 'Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model', Allergy: European Journal of Allergy and Clinical Immunology, vol. 75, no. 2, pp. 475-478. 5
2019	Endo, Y, Onodera, A, Obata-Ninomiya, K, Koyama-Nasu, R, Asou, HK, Ito, T, Yamamoto, T, Kanno, T, Nakajima, T, Ishiwata, K, Kanuka, H, Tumes, DJ & Nakayama, T 2019, 'ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis', Nature Metabolism, vol. 1, no. 2, pp. 261-275. 4 2 13
2019	Ichikawa, T, Hirahara, K, Kokubo, K, Kiuchi, M, Aoki, A, Morimoto, Y, Kumagai, J, Onodera, A, Mato, N, Tumes, DJ, Goto, Y, Hagiwara, K, Inagaki, Y, Sparwasser, T, Tobe, K & Nakayama, T 2019, 'CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells', Nature Immunology, vol. 20, no. 11, pp. 1469-1480. 7 1 14
2019	Tumes, D, Hirahara, K, Papadopoulos, M, Shinoda, K, Onodera, A, Kumagai, J, Yip, KH, Pant, H, Kokubo, K, Kiuchi, M, Aoki, A, Obata-Ninomiya, K, Tokoyoda, K, Endo, Y, Kimura, MY & Nakayama, T 2019, 'Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology', Journal of Allergy and Clinical Immunology, vol. 144, no. 2, pp. 549-560.e 10. Open access 7 3 2
2019	Yip, KH, Papadopoulos, M, Pant, H & Tumes, DJ 2019, 'The role of invariant T cells in inflammation of the skin and airways', Seminars in Immunopathology, vol. 41, no. 3, pp. 401-410. 4 1 1
2018	Lynn, MA, Tumes, DJ, Choo, JM, Sribnaia, A, Blake, SJ, Leong, LEX, Young, GP, Marshall, HS, Wesselingh, SL, Rogers, GB & Lynn, DJ 2018, 'Early-life antibiotic-driven dysbiosis leads to dysregulated vaccine immune responses in mice', Cell Host and Microbe, vol. 23, no. 5, pp. 653-660.e5. 27 18 87
2018	Yamamoto, T, Endo, Y, Onodera, A, Hirahara, K, Asou, HK, Nakajima, T, Kanno, T, Ouchi, Y, Uematsu, S, Nishimasu, H, Nureki, O, Tumes, DJ, Shimojo, N & Nakayama, T 2018, 'DUSP10 constrains innate IL-33-mediated cytokine production in ST2ʰᶦ memory-type pathogenic Th2 cells', Nature Communications, vol. 9, no. 1, article no. 4231, pp. 1-15. Open access 7 5 1
2017	Nakayama, T, Hirahara, K, Onodera, A, Endo, Y, Hosokawa, H, Shinoda, K, Tumes, DJ & Okamoto, Y 2017, 'Th2 cells in health and disease', Annual Review of Immunology, ch. 3, pp. 53-84. 85 68 1
2017	Tumes, DJ, Papadopoulos, M, Endo, Y, Onodera, A, Hirahara, K & Nakayama, T 2017, 'Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma', Immunological Reviews, vol. 278, no. 1, pp. 8-19. 26 21 1
2016	Angela, M, Endo, Y, Asou, HK, Yamamoto, T, Tumes, DJ, Tokuyama, H, Yokote, K & Nakayama, T 2016, 'Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells', Nature Communications, vol. 7, article no. 13683, pp. 1-15. Open access 78 65 4
2016	Hayashizaki, K, Kimura, MY, Tokoyoda, K, Hosokawa, H, Shinoda, K, Hirahara, K, Ichikawa, T, Onodera, A, Hanazawa, A, Iwamura, C, Kakuta, J, Muramoto, K, Motohashi, S, Tumes, DJ, Iinuma, T, Yamamoto, H, Ikehara, Y, Okamoto, Y & Nakayama, T 2016, 'Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation', Science Immunology, vol. 1, no. 3, article no. eaaf9154. 15 17 91
2016	Shinoda, K, Hirahara, K, Iinuma, T, Ichikawa, T, Suzuki, AS, Sugaya, K, Tumes, DJ, Yamamoto, H, Hara, T, Tani-ichi, S, Ikuta, K, Okamoto, Y & Nakayama, T 2016, 'Thy1+ IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation', Proceedings of the National Academy of Sciences of USA, vol. 113, no. 20, pp. E2842-E2851. Open access 63 46 2
2015	Endo, Y, Asou, HK, Matsugae, N, Hirahara, K, Shinoda, K, Tumes, DJ, Tokuyama, H, Yokote, K & Nakayama, T 2015, 'Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1', Cell Reports, vol. 12, no. 6, pp. 1042-1055. Open access 69 64 21
2015	Endo, Y, Hirahara, K, Iinuma, T, Shinoda, K, Tumes, DJ, Asou, HK, Matsugae, N, Obata-Ninomiya, K, Yamamoto, H, Motohashi, S, Oboki, K, Nakae, S, Saito, H, Okamoto, Y & Nakayama, T 2015, 'The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway', Immunity, vol. 42, no. 2, pp.294-308. Open access 113 94 2
2015	Hosokawa, H, Kato, M, Tohyama, H, Tamaki, Y, Endo, Y, Kimura, MY, Tumes, DJ, Motohashi, S, Matsumoto, M, Nakayama, K I, Tanaka, T & Nakayama, T 2015, 'Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells', Journal of Biological Chemistry, vol. 290, no. 21, pp. 13095-13103. Open access 14 13 1
2015	Onodera, A, Tumes, DJ, Watanabe, Y, Hirahara, K, Kaneda, A, Sugiyama, F, Suzuki, Y & Nakayama, T 2015, 'Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes', Molecular and Cellular Biology, vol. 35, no. 22, pp. 3841-3853. Open access 10 12
2014	Endo, Y, Hirahara, K, Yagi, R, Tumes, DJ & Nakayama, T 2014, 'Pathogenic memory type Th2 cells in allergic inflammation', Trends in Immunology, vol. 35, no. 2, pp. 69-78. 74 69 1
2014	Watanabe, Y, Onodera, A, Kanai, U, Ichikawa, T, Obata-Ninomiya, K, Wada, T, Kiuchi, M, Iwamura, C, Tumes, DJ, Shinoda, K, Yagi, R, Motohashi, S, Hirahara, K & Nakayama, T 2014, 'Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 35, pp. 12829-12834. Open access 13 9 1
2013	Hosokawa, H, Tanaka, T, Suzuki, Y, Iwamura, C, Ohkubo, S, Endoh, K, Kato, M, Endo, Y, Onodera, A, Tumes, DJ, Kanai, A, Sugano, S & Nakayama, T 2013, 'Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 12, pp. 4691-4696. Open access 46 43
2013	Tumes, DJ, Onodera, A, Suzuki, A, Shinoda, K, Endo, Y, Iwamura, C, Hosokawa, H, Koseki, H, Tokoyoda, K, Suzuki, Y, Motohashi, S & Nakayama, T 2013, 'The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells', Immunity. Open access 133 121 8
2012	Iwamura, C, Shinoda, K, Endo, Y, Watanabe, Y, Tumes, DJ, Motohashi, S, Kawahara, K, Kinjo, Y & Nakayama, T 2012, 'Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo', Proceedings of the National Academy of Sciences of USA, vol. 109, no. 42, pp. 16992-16997. Open access 14 17
2012	Kuwahara, M, Yamashita, M, Shinoda, K, Tofukuji, S, Onodera, A, Shinnakasu, R, Motohashi, S, Hosokawa, H, Tumes, D, Iwamura, C, Lefebvre, V & Nakayama, T 2012, 'The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation', Nature Immunology, vol. 13, no. 8, pp. 778-786. Open access 90 80 8
2012	Shinoda, K, Tokoyoda, K, Hanazawa, A, Hayashizaki, K, Zehentmeier, S, Hosokawa, H, Iwamura, C, Koseki, H, Tumes, DJ, Radbruch, A & Nakayama, T 2012, 'Type II membrane protein CD69 regulates the formation of resting T-helper memory', Proceedings of the National Academy of Sciences of USA, vol. 109, no. 19, pp. 7409-7414. Open access 71 70 4
2012	Yamashita, J, Iwamura, C, Mitsumori, K, Hosokawa, H, Sasaki, T, Takahashi, M, Tanaka, H, Kaneko, K, Hanazawa, A, Watanabe, Y, Shinoda, K, Tumes, D, Motohashi, S & Nakayama, T 2012, 'Murine Schnurri-2 controls natural killer cell function and lymphoma development', Leukemia and Lymphoma, vol. 53, no. 3, pp. 479-486. 3 2
2011	Endo, Y, Iwamura, C, Kuwahara, M, Suzuki, A, Sugaya, K, Tumes, DJ, Tokoyoda, K, Hosokawa, H, Yamashita, M & Nakayama, T 2011, 'Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3', Immunity, vol. 35, no. 5, pp. 733-745. Open access 77 70
2011	Kitajima, M, Ito, T, Tumes, DJ, Endo, Y, Onodera, A, Hashimoto, K, Motohashi, S, Yamashita, M, Nishimura, T, Ziegler, SF & Nakayama, T 2011, 'Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells', Cancer Research, vol. 71, no. 14, pp. 4790-4798. Open access 17 15
2010	Suzuki, A, Iwamura, C, Shinoda, K, Tumes, DJ, Kimura, MY, Hosokawa, H, Endo, Y, Horiuchi, S, Tokoyoda, K, Koseki, H, Yamashita, M & Nakayama, T 2010, 'Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung', Journal of Immunology, vol. 184, no. 8, pp. 4510-4520. Open access 15 14
2009	Tumes, DJ, Connolly, A & Dent, LA 2009, 'Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma', International Immunology, vol. 21, no. 6, pp. 633-644. Open access 19 15
2008	Giacomin, P, Cava, M, Tumes, D, Gauld, A, Iddawela, D, Mccoll, S, Parsons, J, Gordon, D & Dent, L 2008, 'Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis', Parasite Immunology, vol. 30, no. 8, pp. 435-445. 9 7
2008	Tumes, DJ, Wong, AC, Sewell, WA, McColl, SR, Connolly, A & Dent, LA 2008, 'Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice', Molecular Immunology, vol. 45, no. 13, pp. 3609-3617. 7 8

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
AMED	JAPAN
Benaroya Research Institute	UNITED STATES
Chiba Institute of Technology	JAPAN
Chiba University	JAPAN
Cleveland Clinic Foundation	UNITED STATES
CSL Limited	AUSTRALIA
Department of Primary Industries	AUSTRALIA
Deutsches Rheuma-Forschungszentrum	GERMANY
Deutsches Rheuma-Forschungszentrum Berlin, Leibniz Institute	GERMANY
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
German Rheumatism Research Center	GERMANY
Hokkaido University	JAPAN
Japan Science and Technology Agency	JAPAN
Jichi Medical University	JAPAN
Jikei University School Of Medicine	JAPAN
Johannes Gutenberg University of Mainz	GERMANY
Kan Research Institute	JAPAN
Kanto Gakuen University	JAPAN
Kyoto University	JAPAN
Leibniz Institute	GERMANY
National Institute of Allergy and Infectious Diseases	UNITED STATES
National Institute of Infectious Diseases (NIID)	JAPAN
National Research Institute for Child Health and Development, Tokyo	JAPAN
Nihon Pharmaceutical Co Ltd	JAPAN
Research Center for Allergy and Immunology	JAPAN
Riken	JAPAN
Royal Victorian Eye and Ear Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
Taiho Pharmaceutical Co	UNITED STATES
Tokai University	JAPAN
University of Adelaide	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Tokyo	JAPAN
University of Toyama	JAPAN
University of Tsukuba	JAPAN
University ofTokyo	JAPAN
Victor Chang Cardiac Research Institute	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Associate Faculty Member F1000	2018
Grant Review Panel National Health and Medical Research Council (NHMRC)	2018
Guest Editor Clinical and Translational Immunology	2018
Member American Association of Immunologists (AAI)	2018
Member Japanese Society for Immunology (JSI)	2018
Member Australasian Society for Immunology (ASI)	2018
Reviewer Immunology and Cell Biology	2018
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2018
Invited expert panel member/speaker SciPubAllergies: nothing to sneeze at, Adelaide	2017
Member American Association of Immunologists (AAI)	2017
Member Japanese Society for Immunology (JSI)	2017
Member Australasian Society for Immunology (ASI)	2017
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2017
Invited conference presentation Epigenetics Consortium of South Australia, Adelaide	2016
Keynote speaker Australasian Society for Immunology (ASI), Adelaide Immunology Retreat, Australia	2016
Member American Association of Immunologists (AAI)	2016
Member Japanese Society for Immunology (JSI)	2016
Member Australasian Society for Immunology (ASI)	2016
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2016
Session Chair Australian Society for Medical Research South Australian Scientific Meeting Adelaide	2016
Invited conference presentation 17th Fenner Conference and 45th Annual Scientific Meeting, Australasian Society for Immunology, Canberra	2015
Invited speaker Departmental Seminar, School of Molecular and Biomedical Science, University of Adelaide	2015
Member American Association of Immunologists (AAI)	2015
Member Japanese Society for Immunology (JSI)	2015
Member Australasian Society for Immunology (ASI)	2015
Organising committee Australasian Society for Immunology (ASI), Adelaide Immunology Retreat, Australia	2015
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2015
Invited conference presentation 3rd Chiba-Uppsala Academia Joint Workshop; Inflammation, Metabolic Diseases and Cancer, Japan	2014
Invited conference presentation 24th Kyoto T Cell Conference, Japan	2014
Member American Association of Immunologists (AAI)	2014
Member Japanese Society for Immunology (JSI)	2014
Member Australasian Society for Immunology (ASI)	2014
Senior Research Fellow South Australian Health and Medical Research Institute (SAHMRI) and Chiba University, Japan	2014
Session Chair 3rd Chiba-Uppsala Academia Joint Workshop; Inflammation, Metabolic Diseases and Cancer, Japan	2014
Invited speaker Departmental Seminar, Protein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Cambridge, England	2013
Invited to present report National News Broadcast, NHK, Japan	2013
Member American Association of Immunologists (AAI)	2013
Member Japanese Society for Immunology (JSI)	2013
Member Australasian Society for Immunology (ASI)	2013
Member Japanese Society for Immunology (JSI)	2012
Member Australasian Society for Immunology (ASI)	2012
Member Japanese Society for Immunology (JSI)	2011
Member Australasian Society for Immunology (ASI)	2011
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2011
Member Australasian Society for Immunology (ASI)	2010
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2010
EAACI Poster Presentation Award XXVI Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Goteborg, Sweden	2009
Member Australasian Society for Immunology (ASI)	2009
Member Australian Society for Medical Research (ASMR)	2009
Postdoctoral fellowship Japan Society for the Promotion of Science (JSPS)	2009
Research Fellow Global Centre for Excellence (G-COE), Faculty of Medicine, Department of Immunology, Chiba University	2009
Adelaide branch co-organiser World Day of Immunology	2008
Member Australasian Society for Immunology (ASI)	2008
Member Australian Society for Medical Research (ASMR)	2008

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Utilising drug delivery systems to overcome antibiotic resistance	Current

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Dr Damon Tumes

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Associate Faculty Member

Grant Review Panel

Guest Editor

Member

Member

Member

Reviewer

Senior Research Fellow

Invited expert panel member/speaker

Member

Member

Member

Senior Research Fellow

Invited conference presentation

Keynote speaker

Member

Member

Member

Senior Research Fellow

Session Chair

Invited conference presentation

Invited speaker

Member

Member

Member

Organising committee

Senior Research Fellow

Invited conference presentation

Invited conference presentation

Member

Member

Member

Senior Research Fellow

Session Chair

Invited speaker

Invited to present report

Member

Member

Member

Member

Member

Member

Member

Postdoctoral fellowship

Member

Postdoctoral fellowship

EAACI Poster Presentation Award

Member

Member

Postdoctoral fellowship

Research Fellow

Adelaide branch co-organiser

Member

Member

Teaching & student supervision

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

Gallery