Dr David Stacey

Research Fellow UniSA Clinical & Health Sciences

email David.Stacey@unisa.edu.au

Research Degree Supervisor

About me

Psychiatric genetics
Cardiovascular genetics
Functional genetics
Immune mechanisms
Molecular QTLs

I joined UniSA in March 2023 from the University of Cambridge, UK, where I was a Senior Research Associate leading the Integrative Genomics team within the Cardiovascular Epidemiology Unit. I am a functional geneticist interested in translating genetic discoveries into an improved biological understanding of disease, with a primary focus on psychiatric illness and cardiovascular disease. I initially trained as a wet-lab scientist, but have since transitioned into bioinformatic and genetic epidemiological methods.

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

Tweets by @UniversitySA

Orcid
Scopus

Research

Research focus

Biological Sciences
Medical and Health Sciences
Psychology and Cognitive Sciences
Clinical Sciences
Immunology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2023	Zhao, JH, Stacey, D, Eriksson, N, Macdonald-Dunlop, E & Peters, JE and 41 other authors and 1 consortium 2023, 'Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets', Nature Immunology, vol. 24, pp. 1450-1551. Open access 187 181 85
2022	Pisanu, C, Severino, G, De Toma, I, Dierssen, M, Fusar-Poli, P, Gennarelli, M, Lio, P, Maffioletti, E, Maron, E, Mehta, D, Minelli, A, Potier, M-C, Serretti, A, Stacey, D, van Westrhenen, R, Xicota, L, Baune, BT & Squassina, A 2022, 'Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review', European Neuropsychopharmacology, vol. 55, pp. 112-157. 7 6 6
2022	Stacey, D, Chen, L, Stanczyk, PJ, Howson, JM & Paul, DS and 90 other authors 2022, 'Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus', Nature Communications, vol. 13, no. 1, article no.1222, pp. 1-15. Open access 6 6 12
2022	Xicota, L, De Toma, I, Maffioletti, E, Pisanu, C, Squassina, A, Baune, BT, Potier, MC, Stacey, D & Dierssen, M 2022, 'Recommendations for pharmacotranscriptomic profiling of drug response in CNS disorders', European Neuropsychopharmacology, vol. 54, pp. 41-53. 6 6 9

Journal Articles

Year	Output
2024	Duko, B, Mengistu, TS, Stacey, D, Moran, LJ, Tessema, G, Pereira, G, Bedaso, A, Gebremedhin, AT, Alati, R, Ayonrinde, OT, Benyamin, B, Lee, SH & Hyppönen, E 2024, 'Associations between maternal preconception and pregnancy adiposity and neuropsychiatric and behavioral outcomes in the offspring: a systematic review and meta-analysis', Psychiatry Research, vol. 342, article no. 116149, pp. 1-20. Open access
2024	Mulugeta, A, Lumsden, A, Madakkatel, I, Stacey, D, Lee, SH, Mäenpää, J, Oehler, M & Hypponen, E 2024, 'Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers', Cancer Medicine, vol. 13, no. 4, article no. e7051, pp. 1-13. Open access
2024	Stacey, D, Benyamin, B, Lee, SH & Hyppönen, E 2024, 'A metabolome-wide Mendelian randomization study identifies dysregulated arachidonic acid synthesis as a potential causal risk factor for bipolar disorder', Biological Psychiatry, vol. 96, no 6, pp. P455-462. Open access 3 277
2024	Stacey, D, Suppiah, V, Benyamin, B, Lee, SH & Hyppönen, E 2024, 'In-silico functional analyses identify TMPRSS15-mediated intestinal absorption of lithium as a modulator of lithium response in bipolar disorder', Journal of Affective Disorders, vol. 358, pp. 416-421. Open access 1 1
2023	Sathyanarayanan, A, Mueller, TT, Ali Moni, M, Schueler, K, Stacey, D & Xicota, L and 21 other authors 2023, 'Multi-omics data integration methods and their applications in psychiatric disorders', European Neuropsychopharmacology, vol. 69, pp. 26-46. 27 25 10
2023	Zhao, JH, Stacey, D, Eriksson, N, Macdonald-Dunlop, E & Peters, JE and 41 other authors and 1 consortium 2023, 'Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets', Nature Immunology, vol. 24, pp. 1450-1551. Open access 187 181 85
2022	Pisanu, C, Severino, G, De Toma, I, Dierssen, M, Fusar-Poli, P, Gennarelli, M, Lio, P, Maffioletti, E, Maron, E, Mehta, D, Minelli, A, Potier, M-C, Serretti, A, Stacey, D, van Westrhenen, R, Xicota, L, Baune, BT & Squassina, A 2022, 'Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review', European Neuropsychopharmacology, vol. 55, pp. 112-157. 7 6 6
2022	Stacey, D, Chen, L, Stanczyk, PJ, Howson, JM & Paul, DS and 90 other authors 2022, 'Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus', Nature Communications, vol. 13, no. 1, article no.1222, pp. 1-15. Open access 6 6 12
2022	Xicota, L, De Toma, I, Maffioletti, E, Pisanu, C, Squassina, A, Baune, BT, Potier, MC, Stacey, D & Dierssen, M 2022, 'Recommendations for pharmacotranscriptomic profiling of drug response in CNS disorders', European Neuropsychopharmacology, vol. 54, pp. 41-53. 6 6 9
2021	Ahluwalia, TS, Prins, BP, Abdollahi, M, Armstrong, NJ, Stacey, D & Alizadeh, BZ 125 other authors and 1 Working Group (claiming author is part of the Group) 2021, 'Genome-wide association study of circulating interleukin 6 levels identifies novel loci', Human Molecular Genetics, vol. 30, no. 5, pp. 393-409. Open access 29 28 10
2021	Harshfield, EL, Fauman, EB, Stacey, D, Paul, DS & Koulman, A and 25 other authors 2021, 'Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci', BMC Medicine, vol. 19, no. 1, article number 232, pp. 1-17. Open access 30 30 28
2020	Ciobanu, LG, Sachdev, PS, Trollor, JN, Reppermund, S, Thalamuthu, A, Mather, KA, Cohen-Woods, S, Stacey, D, Toben, C, Schubert, KO & Baune, BT 2020, 'Downregulated transferrin receptor in the blood predicts recurrent MDD in the elderly cohort: A fuzzy forests approach', Journal of Affective Disorders, vol. 267, pp. 42-48. Open access 10 10 2
2019	Harshfield, EL, Koulman, A, Ziemek, D, Marney, L, Stacey, D & Griffin, JL 2019, 'An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors.', Journal of Proteome Research, vol. 18, no. 6, pp. 2397-2410. Open access 50 46 18
2019	Stacey, D, Fauman, EB, Ziemek, D, Sun, BB, Harshfield, EL, Wood, AM, Butterworth, AS, Suhre, K & Paul, DS 2019, 'ProGeM: a framework for the prioritization of candidate causal genes at molecular quantitative trait loci', Nucleic Acids Research, vol. 47, no. 1, article no. e3. Open access 63 35
2018	Ciobanu, LG, Sachdev, PS, Trollor, JN, Reppermund, S, Thalamuthu, A, Mather, KA, Cohen-Woods, S, Stacey, D, Toben, C, Schubert, KO & Baune, BT 2018, 'Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adults', Journal of Psychiatric Research, vol. 107, pp. 19-27. 24 23 2
2018	Cohen-Woods, S, Fisher, H, Ahmetspahic, D, Douroudis, K, Stacey, D, Hosang, G, Korszun, A, Owen, M, Craddock, N, Arolt, V, Dannowski, U, Breen, G, Craig, I, Farmer, A, Baune, B, Lewis, C, Uher, R & McGuffin, P 2018, 'Interaction between childhood maltreatment on immunogenetic risk in depression: discovery and replication in clinical case-control samples', Brain Behavior and Immunity, vol. 67, pp. 203-210. Open access 30 28 4
2018	Culverhouse, R, Saccone, N, Horton, A, Ma, Y, Stacey, D & Bierut, L 2018, 'Collaborative meta-Analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression', Molecular Psychiatry, vol. 23, no. 1, pp. 133-142. Open access 242 196 620
2018	Stacey, D, Schubert, KO, Clark, SR, Amare, AT, Milanesi, E, Maj, C, Leckband, SG, Shekhtman, T, Kelsoe, JR, Gurwitz, D & Baune, BT 2018, 'A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder', Translational Psychiatry, vol. 8, no. 1, article no. 183. Open access 24 20 4
2018	Sun, BB, Maranville, JC, Peters, JE, Stacey, D & Butterworth, AS 2018, 'Genomic atlas of the human plasma proteome', Nature, vol. 558, no. 7708, pp. 73-79. Open access 1115 1106 591
2018	van der Laan, SW, Harshfield, EL, Hemerich, D, Stacey, D, Wood, AM & Asselbergs, FW 2018, 'From lipid locus to drug target through human genomics', Cardiovascular Research, vol. 114, no. 9, pp. 1258-1270. Open access 25 23 5
2017	Stacey, D, Ciobanu, LG & Baune, BT 2017, 'A systematic review on the association between inflammatory genes and cognitive decline in non-demented elderly individuals', European Neuropsychopharmacology, vol. 27, no. 6, pp. 568-588. 23 22 11
2017	Stacey, D, Redlich, R, Büschel, A, Opel, N, Grotegerd, D, Zaremba, D, Dohm, K, Bürger, C, Meinert, S, Förster, K, Repple, J, Kaufmann, C, Kugel, H, Heindel, W, Arolt, V, Dannlowski, U & Baune, B 2017, 'TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes (VBM) in healthy adults', Genes Brain and Behavior, vol. 16, no. 3, pp. 352-360. 17 16 11
2016	Grosse, L, Ambrée, O, Jörgens, S, Jawahar, MC, Singhal, G, Stacey, D, Arolt, V & Baune, BT 2016, 'Cytokine levels in major depression are related to childhood trauma but not to recent stressors', Psychoneuroendocrinology, vol. 73, pp. 24-31. 87 81 2
2016	Stacey, D, Lourdusamy, A, Ruggeri, B, Maroteaux, M & Schumann, G 2016, 'A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males', Journal of Psychiatry and Neuroscience, vol. 41, no. 3, pp. 192-202. Open access 14 12

Reports

Year	Output
2024	Shepherd, R, Suppiah, V & Stacey, D 2024, Elucidating the genetic connection between psychiatric disorders, antipsychotics, and metabolic syndrome in GWAS, Prospero, Australia. Open access

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Barcelona Institute of Science and Technology	SPAIN
Cardiff University	UNITED KINGDOM
Curtin University	AUSTRALIA
Dalhousie University	CANADA
Flinders University	AUSTRALIA
Frankfurt Psychoanalytic Institute	GERMANY
Institute for Artificial Intelligence and Informatics in Medicine	GERMANY
IRCCS Centro San Giovanni di Dio Fatebenefratelli	ITALY
King's College London	UNITED KINGDOM
Merck	UNITED STATES
Monash University	AUSTRALIA
Murdoch University	AUSTRALIA
NIHR Cambridge Biomedical Research Centre	UNITED KINGDOM
Parnassia Psychiatric Institute	NETHERLANDS
Pfizer Australia Pty Ltd	AUSTRALIA
Pfizer Worldwide Research and Development	UNITED STATES
Pitié-Salpêtrière Hospital	FRANCE
Queen Mary University of London	UNITED KINGDOM
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Seattle University	UNITED STATES
Steno Diabetes Center Copenhagen	DENMARK
Tampere University	FINLAND
Tel Aviv University	ISRAEL
University of Adelaide	AUSTRALIA
University of Bologna	ITALY
University of Brescia	ITALY
University of Cagliari	ITALY
University of California	UNITED STATES
University of Cambridge	UNITED KINGDOM
University of Edinburgh	UNITED KINGDOM
University of Groningen	NETHERLANDS
University of Leicester	UNITED KINGDOM
University of London	UNITED KINGDOM
University of Melbourne	AUSTRALIA
University of Münster	GERMANY
University of New South Wales	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Tartu	ESTONIA
University of Western Australia	AUSTRALIA
Uppsala University	SWEDEN
Utrecht University	NETHERLANDS
Washington University in St Louis	UNITED STATES
Weill Cornell Medical College in Qatar	QATAR

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Assessing non-HLA genetic markers in susceptibility to Type I Diabetes and environmental risk factors: A genome-wide association study	Current
Elucidating the role of inflammation in psychiatric disorders	Current
Exploring the Genetic Association between Cardiometabolic Abnormalities in Clozapine in Treatment-Resistant Schizophrenia	Current
Investigation of alcohol use and its consequences on human health	Current
Unraveling the link between blood proteins biomarkers and the risk of depression: a large-scale data-driven study	Current

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Dr David Stacey

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

Reports

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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