Dr Denis Tvorogov

Senior Research Fellow Centre for Cancer Biology

City West Campus (HB11-29)
tel +61 8 830 27952

email Denis.Tvorogov@unisa.edu.au

Research

Research focus

Clinical Sciences
Cardiovascular Medicine and Haematology
Biochemistry and Cell Biology
Medical and Health Sciences
Oncology and Carcinogenesis

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2023	Shing, KS, Kan, WL, Nero, TL, Hercus, TR, Tvorogov, D, Metcalfe, RD, Griffin, MD, De Weerd, NA, Guthridge, MA, Hertzog, PJ, Lopez, AF & Parker, MW 2023, 'Cytokine receptors and their ligands', in Ralph A Bradshaw et al. (eds), Encyclopedia of Cell Biology, 2nd, Elsevier, UK, vol. 4, pp. 21-45. 2

Journal Articles

Year	Output
2025	Kan, WL, Weekley, CM, Nero, TL, Hercus, TR, Yip, KH, Tumes, DJ, Woodcock, JM, Ross, DM, Thomas, D, Terán, D, Owczarek, CM, Liu, NW, Martelotto, LG, Polo, JM, Pant, H, Tvorogov, D, Lopez, AF & Parker, MW 2025, 'The β common cytokine receptor family reveals new functional paradigms from structural complexities', Immunological Reviews, vol. 329, no. 1, pp. 1-25. Open access 1 1
2024	Cildir, G, Aba, U, Pehlivan, D, Tvorogov, D, Warnock, N I, Kok, CH, Tumes, DJ & Erman, B and 17 other authors 2024, 'Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans', Nature Communications, vol. 15, no. 1, pp. 1-18. Open access 9
2024	Thompson, EJ, Escarbe, S, Tvorogov, D, Farshid, G, Gregory, PA, Khew-Goodall, Y, Madden, S, Ingman, W V, Lindeman, GJ, Lim, E, Lopez, AF & Bonder, CS 2024, 'Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis', Growth Factors, vol. 42, no. 2, pp. 49–61. Open access 1
2023	Kan, WL, Dhagat, U, Kaufmann, KB, Hercus, TR, Toubia, J, Barry, EF, Gomez, GA, Dottore, M, Samaraweera, SE, Goodall, GJ, Thomas, D, Tvorogov, D, D'Andrea, RJ & Lopez, AF and 12 other authors 2023, 'Distinct assemblies of heterodimeric cytokine receptors govern stemness programs in leukemia', Cancer Discovery, vol. 13, no. 8, pp. 1922-1947. Open access 8 7 19
2023	Nair, PC, Piehler, J, Tvorogov, D, Ross, DM, Lopez, AF, Gotlib, J & Thomas, D 2023, 'Next-generation JAK2 inhibitors for the treatment of myeloproliferative neoplasms: lessons from structure-based drug discovery approaches', BLOOD CANCER DISCOVERY, vol. 4, no. 5, pp. 352-364. 8 5 8
2022	Brown, GJ, Cañete, PF, Wang, H, Medhavy, A, Tvorogov, D, Lopez, AF & Vinuesa, CG and 37 other authors 2022, 'TLR7 gain-of-function genetic variation causes human lupus', Nature, vol. 605, no. 7909, pp. 349-356. Open access 323 309 1908
2022	Tvorogov, D, Thompson-Peach, CA, Foßelteder, J, Dottore, M, Stomski, F, Onnesha, SA, Lim, K, Moretti, PA, Pitson, SM, Ross, DM, Reinisch, A, Thomas, D & Lopez, AF 2022, 'Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody', EMBO Reports, vol. 23, no. 4, article no. e52904. Open access 19 19 12
2021	Kan, WL, Cheung Tung Shing, KS, Nero, TL, Hercus, TR, Tvorogov, D, Parker, MW & Lopez, AF 2021, 'Messing with βc: a unique receptor with many goals', Seminars in Immunology, vol. 54, article 101513, pp. 1-14. Open access 4 4 3
2021	Ross, DM, Babon, JJ, Tvorogov, D & Thomas, D 2021, 'Persistence of myelofibrosis treated with ruxolitinib: biology and clinical implications', Haematologica: The Hematology Journal, vol. 106, no. 5, pp. 1244-1253. Open access 19 16 24
2018	Hercus, TR, Kan, WL, Broughton, SE, Tvorogov, D, Ramshaw, HS, Thompson, EJ, McKenzie, DR, Tergaonkar, V, Hughes, T, Samuel, MS, Bonder, CS, Grimbaldeston, MA & Lopez, A F and 10 other authors 2018, 'Role of the β common (βc) family of cytokines in health and disease', Cold Spring Harbor Perspectives in Biology, vol. 10, no. 6, article no. a028514, pp. 1-26. Open access 36 28 14
2018	Tvorogov, D, Thomas, D, Liau, NP, Dottore, M, Barry, EF, Lathi, M, Kan, WL, Hercus, TR, Stomski, F, Hughes, TP, Tergaonkar, V, Parker, MW, Ross, DM, Majeti, R, Babon, JJ & Lopez, AF 2018, 'Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis', Science Advances, vol. 4, no. 11, article no. eaat3834, pp. 1-13. Open access 41 40 3
2015	Broughton, SE, Nero, TL, Dhagat, U, Kan, WL, Hercus, TR, Tvorogov, D, Lopez, AF & Parker, MW 2015, 'The βc receptor family - Structural insights and their functional implications', Cytokine, vol. 74, no. 2, pp. 247-258. 68 60 3
2015	Moldenhauer, LM, Cockshell, MP, Frost, L, Parham, KA, Tvorogov, D, Tan, LY, Ebert, LM, Tooley, K, Worthley, S, Lopez, AF & Bonder, CS 2015, 'Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties', Stem Cell Research, vol. 14, no. 3, pp. 380-395. Open access 16 15 4
2014	Jeltsch, M, Jha, SK, Tvorogov, D, Anisimov, A, Leppanen, V-M, Holopainen, T, Kivela, R, Ortega, S, Karpanen, T & Alitalo, K 2014, 'CCBE1 enhances lymphangiogenesis via a disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation', Circulation, vol. 129, no. 19, pp. 1962-1971. Open access 189 171
2014	Yao, L-C, Testini, C, Tvorogov, D, Anisimov, A, Vargas, SO, Baluk, P, Pytowski, B, Claesson-Welsh, L, Alitalo, K & McDonald, DM 2014, 'Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period', Circulation Research, vol. 114, no. 5, pp. 806-822. Open access 58 50
2013	Anisimov, A, Leppanen, V-M, Tvorogov, D, Zarkada, G, Jeltsch, M, Holopainen, T, Kaijalainen, S & Alitalo, K 2013, 'The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands', Science Signaling, vol. 6, no. 282, article no. ra52. 47 45
2013	Anisimov, A, Tvorogov, D, Alitalo, AK, Leppanen, V-M, An, Y, Han, EC, Orsenigo, F, Gaál, EI, Holopainen, T, Koh, YJ, Tammela, T, Korpisalo, P, Keskitalo, S, Jeltsch, M, Ylä-Herttuala, S, Dejana, E, Koh, GY, Choi, C, Saharinen, P & Alitalo, K 2013, 'Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis', Circulation, vol. 127, no. 4, pp. 424-434. Open access 49 49
2013	Leppänen, V-M, Tvorogov, D, Kisko, K, Prota, AE, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, KN, Ballmer-Hofer, K & Alitalo, K 2013, 'Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 32, pp. 12960-12965. Open access 88 85
2012	Holopainen, T, Lopez-Alpuche, V, Zheng, W, Heljasvaara, R, Jones, D, He, Y, Tvorogov, D, D'Amico, G, Wiener, Z, Andersson, LC, Pihlajaniemi, T, Min, W & Alitalo, K 2012, 'Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth', Cancer Research, vol. 72, no. 14, pp. 3512-3521. Open access 29 29
2012	Keuschnigg, J, Tvorogov, D, Elima, K, Salmi, M, Alitalo, K, Salminen, T & Jalkanen, S 2012, 'PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1', Blood, vol. 120, no. 1, pp. 232-235. Open access 18 16
2011	Leppanen, VM, Jeltsch, M, Anisimov, A, Tvorogov, D, Aho, K, Kalkkinen, N, Toivanen, P, Ylä-Herttuala, S, Ballmer-Hofer, K & Alitalo, K 2011, 'Structural determinants of vascular endothelial growth factor-D receptor binding and specificity', Blood, vol. 117, no. 5, pp. 1507-1515. Open access 76 77
2011	Tammela, T, Zarkada, G, Nurmi, H, Jakobsson, L, Heinolainen, K, Tvorogov, D, Zheng, W, Franco, CA, Murtomaki, A, Aranda, E, Miura, N, Yla-Herttualala, S, Fruttiger, M, Makinen, T, Eichmann, A, Pollard, JW, Gerhardt, H & Alitalo, K 2011, 'VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling', Nature Cell Biology, vol. 13, no. 10, pp. 1202-1213. Open access 263 230
2010	Sundvall, M, Veikkolainen, V, Kurppa, K, Salah, Z, Tvorogov, D, van Zoelen, EJ, Aqeilan, R & Elenius, K 2010, 'Cell death or survival promoted by alternative isoforms of ErbB4', Molecular Biology of the Cell, vol. 21, no. 23, pp. 4275-4286. Open access 52 48
2010	Tvorogov, D, Anisimov, A, Zheng, W, Leppanen, V-M, Tammela, T, Laurinavicius, S, Holnthoner, W, Helotera, H, Holopainen, T, Jeltsch, M, Kalkkinen, N, Lankinen, H, Ojala, PM & Alitalo, K 2010, 'Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization', Cancer Cell, vol. 18, no. 6, pp. 630-640. Open access 121 110
2010	Zhou, F, Chang, Z, Zhang, L, Hong, Y-K, Shen, B, Wang, B, Zhang, F, Lu, G, Tvorogov, D, Alitalo, K, Hemmings, BA, Yang, Z & He, Y 2010, 'Akt/protein kinase B is required for lymphatic network formation, remodeling, and valve development', American Journal of Pathology, vol. 177, no. 4, pp. 2124-2133. Open access 91 85
2009	Iivainen, E, Lauttia, S, Zhang, N, Tvorogov, D, Kulmala, J, Grenman, R, Salven, P & Elenius, K 2009, 'The EGFR inhibitor gefitinib suppresses recruitment of pericytes and bone marrow-derived perivascular cells into tumor vessels', Microvascular Research, vol. 78, no. 3, pp. 278-285. 33 26
2009	Tvorogov, D, Sundvall, M, Kurppa, K, Hollmen, M, Johnson, MS & Elenius, K 2009, 'Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer', Journal of Biological Chemistry, vol. 284, no. 9, pp. 5582-5591. Open access 59 54

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Abo Academy University	FINLAND
Albert Einstein College of Medicine	UNITED STATES
Australian National University	AUSTRALIA
BreastScreen SA	AUSTRALIA
Cancer Research Uk	UNITED KINGDOM
College de France	FRANCE
CSL Limited	AUSTRALIA
Deakin University	AUSTRALIA
Friedrich Miescher Institute for Biomedical Research	SWITZERLAND
Genentech, Inc.	UNITED STATES
Hacettepe University	TÜRKIYE
Hamamatsu University School of Medicine	JAPAN
Harvard University	UNITED STATES
Hebrew University	MEXICO
Hubrecht Institute	NETHERLANDS
Hudson Institute of Medical Research	AUSTRALIA
ImClone Systems, Eli Lilly and Company	UNITED STATES
Institute for Molecular Medicine Finland	FINLAND
Institute of Molecular Oncology Foundation	ITALY
Korea Advanced Institute of Science and Technology	KOREA, REPUBLIC OF (SOUTH)
Medical University of Graz	AUSTRIA
Nanjing University	CHINA
Osnabrueck University	GERMANY
Paul Scherrer Institute	SWITZERLAND
Royal College of Surgeons in Ireland	IRELAND
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Spanish National Cancer Research Centre	SPAIN
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
Turku University Hospital	FINLAND
University College London	UNITED KINGDOM
University Health Network	CANADA
University of Adelaide	AUSTRALIA
University of Basel	SWITZERLAND
University of California	UNITED STATES
University of Eastern Finland	FINLAND
University of Helsinki	FINLAND
University of Kuopio	FINLAND
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Nijmegen	NETHERLANDS
University of Oulu	FINLAND
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Turku	FINLAND
Uppsala University	SWEDEN
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Yale University	UNITED STATES

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Dr Denis Tvorogov

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

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