Professor Elina Hypponen

Professor of Nutritional and Genetic Epidemiology UniSA Clinical & Health Sciences

City West Campus (08.301)
tel +61 8 830 22518

email Elina.Hypponen@unisa.edu.au

Alternative contact

Available for media comment
Research Degree Supervisor

About me

Nutrition research
Genetic epidemiology
Risk factor discovery

Professor Hyppönen is the Director of the Australian Centre for Precision Health at the University of South Australia. She was recruited to the UniSA as the Professor in Nutritional and Genetic Epidemiology in 2013, following 12 years at the University College London, Great Ormond Street Institute of Child Health (London, UK).

She holds NHMRC Leadership Investigator Award and appointments as a Senior Principal Research Fellow at the South Australian Health and Medical Research Institute (SAHMRI) and as an Adjunct Professor in Epidemiology at the University of Tampere, Finland. Professor Hyppönen has an interdisciplinary academic background, with academic qualifications in epidemiology, medical statistics, nutrition and... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research focus

Clinical Sciences
Public Health and Health Services
Medical and Health Sciences
Genetics
Biological Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2024	Boucher, BJ & Hyppönen, E 2024, 'Vitamin D, obesity, the metabolic syndrome and its sequelae', in M Hewison et al. (eds), Feldman and Pike's Vitamin D: Volume Two: Disease and Therapeutics, 5th, Academic Press, UK, vol. 1, ch. 75, pp. 489-510.
2024	Hyppönen, E, Zhou, A & Vimaleswaran, KS 2024, 'Genetic determinants of 25-hydroxyvitamin D concentrations', in M Hewison et al. (eds), Feldman and Pike's Vitamin D: Volume Two: Disease and Therapeutics, 5th, Academic Press, UK, vol. 2, ch. 60, pp. 185-199.
2017	Hyppönen, E & Boucher, BJ 2017, 'Vitamin D, obesity, and the metabolic syndrome', Vitamin D, 4, Elsevier, US, ch. 78, pp. 425-444. 3
2010	Hypponen, ET 2010, 'Vitamin D and the Risk of Type 1 Diabet', in Holick, Michael F., Vitamin D Physiology, Molecular Biology, and Clinical Applications, 2, Springer Science, US, ch. 47, pp. 867-880.

Journal Articles

Year	Output
2024	Amente, LD, Mills, NT, Le, TD, Hyppönen, E & Lee, SH 2024, 'Unraveling phenotypic variance in metabolic syndrome through multi-omics', Human Genetics, vol. 143, no. 1, pp. 35-47.
2024	Bradfield, JP, Kember, RL, Ulrich, A, Balkiyarova, Z, Hypponen, E & Cousminer, DL and 100 other authors and 1 consortium 2024, 'Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes', Genome Biology, vol. 25, article no. 22, pp. 1-19. Open access 4 15
2024	Byrne, S, Boyle, T, Ahmed, M, Lee, SH, Benyamin, B & Hyppönen, E 2024, 'Response to: Adherence to the world cancer research fund lifestyle recommendations and incidence of prostate cancer in the UK Biobank', International Journal of Epidemiology, vol. 53, no. 1, article no. dyae009, pp. 1-2. 1
2024	Jayasinghe, D, Momin, MM, Beckmann, K, Hyppönen, E, Benyamin, B & Lee, SH 2024, 'Mitigating type 1 error inflation and power loss in GxE PRS: Genotype-environment interaction in polygenic risk score models', Genetic Epidemiology, vol. 48, no. 2, pp. 85-100. Open access 4
2024	Kassaw, NA, Zhou, A, Mulugeta, A, Lee, SH, Burgess, S & Hyppönen, E 2024, 'Alcohol consumption and the risk of all-cause and cause-specific mortality-a linear and nonlinear Mendelian randomization study', International Journal of Epidemiology, vol. 53, no. 2, pp. 1-8. Open access
2024	Madakkatel, I, Lumsden, AL, Mulugeta, A, Maenpaa, J, Oehler, MK & Hyppönen, E 2024, 'Large-scale analysis to identify risk factors for ovarian cancer', International Journal of Gynecological Cancer, online, pp. 1-9. Open access
2024	Momin, MM, Zhou, X, Hyppönen, E, Benyamin, B & Lee, SH 2024, 'Cross-ancestry genetic architecture and prediction for cholesterol traits', Human Genetics, vol. 143, pp. 635-648.
2024	Mulugeta, A, Lumsden, A, Madakkatel, I, Stacey, D, Lee, SH, Mäenpää, J, Oehler, M & Hypponen, E 2024, 'Phenome-wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers', Cancer Medicine, vol. 13, no. 4, article no. e7051, pp. 1-13. Open access
2024	Stacey, D, Benyamin, B, Lee, SH & Hyppönen, E 2024, 'A metabolome-wide Mendelian randomization study identifies dysregulated arachidonic acid synthesis as a potential causal risk factor for bipolar disorder', Biological Psychiatry, vol. 96, no 6, pp. P455-462. Open access 2
2024	Stacey, D, Suppiah, V, Benyamin, B, Lee, SH & Hyppönen, E 2024, 'In-silico functional analyses identify TMPRSS15-mediated intestinal absorption of lithium as a modulator of lithium response in bipolar disorder', Journal of Affective Disorders, vol. 358, pp. 416-421. Open access 1
2024	Verhoef, E, Allegrini, AG, Jansen, PR, Lange, K, Hypponen, E & St. Pourcain, B 20 explicit authors and 3 consortia. UniSA affiliated author listed in EAGLE Working Group 2024, 'Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with attention-deficit/hyperactivity disorder, literacy, and cognition-related traits', Biological Psychiatry, vol. 95, no. 9, pp. 859-869. Open access 2
2024	Yeshaw, Y, Madakkatel, MI, Mulugeta, A, Lumsden, A & Hyppönen, E 2024, 'Uncovering predictors of low hippocampal volume: evidence from a large-scale machine-learning-based study in the UK biobank', Neuroepidemiology, online, pp. 1-14. Open access
2023	Ahmed, M, Mäkinen, VP, Lumsden, A, Boyle, T, Mulugeta, A, Lee, SH, Olver, I & Hyppönen, E 2023, 'Metabolic profile predicts incident cancer: a large-scale population study in the UK Biobank', Metabolism: Clinical and Experimental, vol. 138, article no. 155342. Open access 5 4 4
2023	Byrne, S, Boyle, T, Ahmed, M, Lee, SH, Benyamin, B & Hyppoenen, E 2023, 'Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types', International Journal of Epidemiology, vol. 52, no. 3, pp. 817-826. Open access 15 14 12
2023	Dickson, C, Zhou, A, MacIntyre, E & Hyppönen, E 2023, 'Do chronic low back pain and chronic widespread pain differ in their association with depression symptoms in the 1958 British cohort?', Pain Medicine, vol. 24, no. 6, pp. 644-651. Open access 3 4 4
2023	Lumme, J, Morin-Papunen, L, Pesonen, P, Sebert, S, Hyppönen, E, Järvelin, M-R, Herzig, K-H, Ojaniemi, M & Niinimäki, M 2023, 'Vitamin D status in women with a history of infertility and decreased fecundability: a population-based study', Nutrients, vol. 15, no. 11, pp. 1-13. Open access 3 10
2023	Lumsden, AL, Mulugeta, A, Makinen, V-P & Hypponen, E 2023, 'Metabolic profile-based subgroups can identify differences in brain volumes and brain iron deposition', Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, vol. 25, no. 1, pp. 121-131. Open access 3 3 128
2023	Madakkatel, I, Lumsden, AL, Mulugeta, A, Olver, I & Hypponen, E 2023, 'Hypothesis-free discovery of novel cancer predictors using machine learning', European Journal of Clinical Investigation, vol. 53, no. 10, article no. e14037, pp. 1-13. Open access 1 39
2023	Mathieson, I, Day, FR, Barban, N, Tropf, FC, Hyppӧnen, E & Perry, JR and 115 other authors and 4 consortia 2023, 'Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus', Nature Human Behaviour, vol. 7, no. 5, pp. 790-801. Open access 13 12 81
2023	Mulugeta, A, Suppiah, V & Hyppönen, E 2023, 'Schizophrenia and co-morbidity risk: evidence from a data driven phenomewide association study', Journal of Psychiatric Research, vol. 162, pp. 1-10. Open access 5 5
2023	Pham, K, Mulugeta, A, Lumsden, A & Hyppӧnen, E 2023, 'Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank', British Journal of Clinical Pharmacology, vol. 89, no. 10, pp. 2992-3004. Open access 2 97
2023	Solé-Navais, P, Flatley, C, Steinthorsdottir, V, Vaudel, M, Jacobsson, B & Hypponen, E and 82 other authors and 3 consortium 2023, 'Genetic effects on the timing of parturition and links to fetal birth weight', Nature Genetics, vol. 55, pp. 559-567. Open access 17 15 251
2023	Sutherland, JP, Zhou, A & Hyppönen, E 2023, 'Muscle traits, sarcopenia, and sarcopenic obesity: a vitamin D Mendelian randomization study', Nutrients, vol. 15, no. 12, pp. 1-13. Open access 3 8
2023	Zhou, A & Hyppönen, E 2023, 'Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study', International Journal of Epidemiology, vol. 52, no. 1, pp. 260-271. Open access 42 40 743
2022	Ahmed, M, Makinen, V-P, Mulugeta, A, Shin, J, Boyle, T, Hypponen, E & Lee, SH 2022, 'Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology', Communications Biology, vol. 5, no. 1, article no. 614, pp. 1-14. Open access 5 3 5
2022	Darooghegi Mofrad, M, Naghshi, S, Lotfi, K, Beyene, J, Hypponen, E, Pirouzi, A & Sadeghi, O 2022, 'Egg and dietary cholesterol intake and risk of all-cause, cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies', Frontiers in Nutrition, vol. 9, article no. 878979, pp. 1-16. Open access 11 9 79
2022	Hyppönen, E, Carslake, D, Berry, DJ, Power, C & Davey Smith, G 2022, 'Estimating the influence of body mass index (BMI) on mortality using offspring BMI as an instrumental variable', International Journal of Obesity, vol. 46, no. 1, pp. 77-84. 3 3 4
2022	Hyppönen, E, Vimaleswaran, KS & Zhou, A 2022, 'Genetic determinants of 25-hydroxyvitamin D concentrations and their relevance to public health', Nutrients, vol. 14, no. 20, article no. 4408, p. 1-14. Open access 21 19 13
2022	Jami, ES, Hammerschlag, AR, Ip, HF, Allegrini, AG, Benyamin, B, Zhou, A, Hypponen, E & Middeldorp, CM and 86 other authors 2022, 'Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 61, no. 7, pp. 934-945. Open access 24 20 121
2022	Lumsden, AL, Mulugeta, A & Hyppönen, E 2022, 'Milk consumption and risk of twelve cancers: a large-scale observational and Mendelian randomisation study', Clinical Nutrition, vol. 42, no. 1, pp. 1-8. Open access 8 7 24
2022	Mulugeta, A, Eshetie, TC, Kassie, GM, Erku, D, Mekonnen, A, Lumsden, A & Hypponen, E 2022, 'Association between metabolically different adiposity subtypes and osteoarthritis: a Mendelian Randomization Study', Arthritis Care and Research, vol. 75, no. 4, pp. 885-892. Open access 7 5 3
2022	Mulugeta, A, Hypponen, E, Ala-Korpela, M & Makinen, V-P 2022, 'Cross-sectional metabolic subgroups and 10-year follow-up of cardiometabolic multimorbidity in the UK Biobank', Scientific Reports, vol. 12, no. 1, article no. 8590, pp. 1-11. Open access 7 7 2
2022	Mulugeta, A, Navale, SS, Lumsden, AL, Llewellyn, DJ & Hyppönen, E 2022, 'Healthy lifestyle, genetic risk and brain health: a gene-environment interaction study in the UK Biobank', Nutrients, vol. 14, no. 19, article no. 3907, pp. 1-13. Open access 5 5 4
2022	Navale, SS, Mulugeta, A, Zhou, A, Llewellyn, DJ & Hyppönen, E 2022, 'Vitamin D and brain health: an observational and Mendelian randomization study', American Journal of Clinical Nutrition, vol. 116, no. 2 , pp. 531-540. Open access 39 37 1335
2022	Neumann, A, Nolte, IM, Pappa, I, Ahluwalia, TS, Benyamin, B, Zhou, A, Hyppönen, E & Tiemeier, H 2022, 'A genome-wide association study of total child psychiatric problems scores', PLoS One, vol. 17, no. 8, article no. e0273116, pp. 1-23. Open access 8 8 14
2022	Pham, K, Mulugeta, A, Zhou, A, O'Brien, JT, Llewellyn, DJ & Hyppönen, E 2022, 'High coffee consumption, brain volume and risk of dementia and stroke', Nutritional Neuroscience, vol. 25, no. 10, pp. 2111-2122. Open access 17 20 1144
2022	Shin, J, Zhou, X, Tan, JT, Hyppönen, E, Benyamin, B & Lee, SH 2022, 'Lifestyle modifies the diabetes-related metabolic risk, conditional on individual genetic differences', Frontiers in Genetics, vol. 13, article no. 759309. Open access 5 5 1
2022	Sutherland, JP, Zhou, A & Hyppönen, E 2022, 'Vitamin D deficiency increases mortality risk in the UK biobank: a nonlinear Mendelian Randomization Study', Annals of Internal Medicine, vol. 175, no. 11, pp. 1552-1559. 62 59 1238
2022	Wang, Z, Emmerich, A, Pillon, NJ, Moore, T, Hyppönen, E & den Hoed, M and 212 other authors and 1 consortium 2022, 'Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention', Nature Genetics, vol. 54, pp. 1332-1344. Open access 63 66 204
2022	Yengo, L, Vedantam, S, Marouli, E, Sidorenko, J, Hypponen, E & Hirschhorn, JN and 622 other authors and 7 consortia 2022, 'A saturated map of common genetic variants associated with human height', Nature, vol. 610, no. 7933, pp. 704-712. Open access 197 176 1423
2021	Ahmed, M, Mulugeta, A, Lee, SH, Mäkinen, V-P, Boyle, T & Hyppönen, E 2021, 'Adiposity and cancer: a Mendelian randomization analysis in the UK biobank', International Journal of Obesity, vol. 45, no. 12, pp. 2657-2665. 18 19 27
2021	Bejar, CA, Goyal, S, Afzal, S, Mangino, M, Zhou, A, Hyppönen, E & Sanghera, DK 2021, 'A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans', Nutrition Journal, vol. 20, pp 1-11. Open access 10 10 19
2021	Hyppönen, E & Zhou, A 2021, 'Cardiovascular symptoms affect the patterns of habitual coffee consumption', American Journal of Clinical Nutrition, vol. 114, no. 1, pp. 214-219. 11 10 723
2021	Lumme, JE, Savukoski, SM, Suvanto, ETJ, Pesonen, PRO, Auvinen, JP, Sebert, S, Hyppönen, E, Järvelin, MR, Puukka, KS, Herzig, KH, Oura, P, Ojaniemi, M & Niinimäki, M 2021, 'Early-onset climacterium is not associated with impaired vitamin D status: a population-based study', Menopause: The Journal of the North American Menopause Society, vol. 28, no. 8, pp. 899-908. 1 1 4
2021	Madakkatel, I, Zhou, A, McDonnell, MD & Hyppönen, E 2021, 'Combining machine learning and conventional statistical approaches for risk factor discovery in a large cohort study', Scientific Reports, vol. 11, issue 1, article no. 22997, pp. 1-11. Open access 15 14
2021	Mills, MC, Tropf, FC, Brazel, DM, van Zuydam, N, Vaez, A, Pers, TH, Snieder, H, Perry, JR, Ong, KK, den Hoed, M, Barban, N, Day, FR & Hyppӧnen, E 2021, 'Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour', Nature Human Behaviour, vol. 5, pp. 1717-1730. 65 58 220
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Relationship between serum 25(Oh)d and depression: causal evidence from a bi-directional mendelian randomization study', Nutrients, vol. 13, no. 1, pp. 1-13. Open access 18 17 30
2021	Mulugeta, A, Lumsden, A & Hyppönen, E 2021, 'Unlocking the causal link of metabolically different adiposity subtypes with brain volumes and the risks of dementia and stroke: a Mendelian randomization study', Neurobiology of Aging, vol. 102, pp. 161-169. Open access 15 16 79
2021	Najjar, L, Sutherland, J, Zhou, A & Hyppönen, E 2021, 'Vitamin D and type 1 diabetes risk: a systematic review and meta-analysis of genetic evidence', Nutrients, vol. 13, no. 12, article no. 4260, pp. 1-15. Open access 10 11 5
2021	Sutherland, JP, Zhou, A, Leach, MJ & Hypponen, E 2021, 'Differences and determinants of vitamin D deficiency among UK biobank participants: a cross-ethnic and socioeconomic study', Clinical Nutrition, vol. 40, no. 5, pp. 3436-3447. 29 25 172
2021	Vimaleswaran, KS, Zhou, A, Cavadino, A & Hyppönen, E 2021, 'Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals', International Journal of Obesity, vol. 45, pp. 1751-1762. Open access 16 15 525
2021	Zhou, A & Hyppönen, E 2021, 'Habitual coffee intake and plasma lipid profile: evidence from UK Biobank', Clinical Nutrition, vol. 40, no. 6, pp. 4404-4413. Open access 15 13 393
2021	Zhou, A, Selvanayagam, JB & Hyppönen, E 2021, 'Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk', European Heart Journal, vol. 43, no. 18, pp. 1731-1739. Open access 115 110 543
2020	Dickson, C & Hypponen, E 2020, 'Precision health: a primer for physiotherapists', Physiotherapy, vol. 107, pp. 66-70. 3 3 1
2020	Hypponen, E 2020, 'Commentary: Intergenerational BMI association: Is there a role for fetal programming?', International Journal of Epidemiology, vol. 49, no. 1, pp. 244-245. Open access 2 2 1
2020	King, C, Mulugeta, A, Nabi, F, Walton, R, Zhou, A & Hyppönen, E 2020, 'Mendelian randomization case-control PheWAS in UK Biobank shows evidence of causality for smoking intensity in 28 distinct clinical conditions', EClinicalMedicine, vol. 26, article no. 100488, pp. 1-7. Open access 16 16 103
2020	Li, LSK, Williams, MT, Johnston, KN, Frith, P, Hypponen, E & Paquet, C 2020, 'Parental and life-course influences on symptomatic airflow obstruction', ERJ Open Research, vol. 6, no. 1, pp. 1-11. Open access 7 7 4
2020	Lumsden, AL, Mulugeta, A, Zhou, A & Hyppönen, E 2020, 'Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank', EBioMedicine, vol. 59, article no. 102954, pp. 1-11. Open access 123 118 77
2020	Mulugeta, A, Zhou, A, King, C & Hyppönen, E 2020, 'Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank', Molecular Psychiatry, vol. 25, no. 7, pp. 1469-1476. Open access 55 56 147
2020	Nicolopoulos, K, Gebremichael, A, Zhou, A & Hypponen, E 2020, 'Association between habitual coffee consumption and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank', Clinical Nutrition, vol. 39, no. 11, pp. 3467-3476. Open access 23 23 178
2020	Palaniswamy, S, Gill, D, De Silva, NM, Lowry, E, Jokelainen, J, Karhu, T, Mutt, SJ, Dehghan, A, Sliz, E, Chasman, D I, Timonen, M, Viinamäki, H, Keinänen-Kiukaanniemi, S, Hyppönen, E, Herzig, KH, Sebert, S & Järvelin, MR 2020, 'Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study', American Journal of Clinical Nutrition, vol. 111, no. 5, pp. 1036-1047. Open access 31 27 41
2020	Stasinopoulos, L, Zhou, A & Hypponen, E 2020, 'Association of supplemental calcium and dairy milk intake with all-cause and cause-specific mortality in the UK Biobank: a prospective cohort study', The British Journal of Nutrition: An International Journal of Nutritional Science, vol. 123, no. 5, pp. 574-582. Open access 8 8 1
2020	Vogelezang, S, Bradfield, JP, Ahluwalia, TS, Curtin, JA, Hyppönen, E & Felix, J and 139 other authors and 1 consortia 2020, 'Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits', PLoS Genetics, vol. 16, no. 10, article no. e1008718, pp. 1-26. Open access 94 88 34
2020	Zheng, Y, Huang, T, Wang, T, Mei, Z, Zhou, A, Hypponen, E & Qi, L and 111 other authors 2020, 'Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood', European Journal of Epidemiology, vol. 35, pp. 685-697. Open access 8 9 42
2020	Zhou, X, van der Werf, J, Carson-Chahhoud, K, Ni, G, McGrath, J, Hyppönen, E & Lee, SH 2020, 'Whole-genome approach discovers novel genetic and nongenetic variance components modulated by lifestyle for cardiovascular health', Journal of the American Heart Association, vol. 9, no. 8, article no. e015661, pp. 1-42. Open access 8 7 31
2019	Alves, AC, De Silva, NMG, Karhunen, V, Sovio, U, Hypponen, E & Jarvelin, MR and 85 other authors and 1 consortia 2019, 'GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI', Science Advances, vol. 5, no. 9, article no. eaaw3095, pp. 1-18. Open access 77 71 84
2019	Bradfield, JP, Vogelezang, S, Felix, JF, Chesi, A, Hyppönen, E & Jaddoe, VW 2019, 'A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity', Human Molecular Genetics, vol. 28, no. 19, pp. 3327-3338. Open access 63 59 50
2019	Folley, S, Zhou, A, Llewellyn, DJ & Hyppenen, E 2019, 'Physical activity, APOE genotype, and cognitive decline: exploring gene-environment interactions in the UK Biobank', Journal of Alzheimer's Disease, vol. 71, no. 3, pp. 741-750. 12 12 21
2019	Gill, D, Benyamin, B, Moore, LS, Monori, G, Zhou, A, Koskeridis, F, Evangelou, E, Laffan, M, Walker, AP, Tsilidis, KK, Dehghan, A, Elliot, P, Hypponen, E, Tzoulaki, I & Rahimi, K 2019, 'Associations of genetically determined iron status across the phenome: a mendelian randomization study', PLoS Medicine, vol. 16, no. 6, article no. e1002833, pp. 1-16. Open access 44 40 125
2019	Huang, T, Wang, T, Zheng, Y, Ellervik, C, Zhou, A, Hyppönen, E & Qi, L and 127 other authors 2019, 'Association of birth weight with type 2 diabetes and glycemic traits: a mendelian randomization study', JAMA network open, vol. 2, no. 9, article no. e1910915, pp. 1-18. Open access 41 38 9
2019	Hypponen, E, Mulugeta, A, Zhou, A & Santhanakrishnan, VK 2019, 'A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank', The Lancet Digital Health, vol. 1, no. 3, pp. e116-e126. Open access 50 48 147
2019	Linnér, RK, Biroli , P, Kong, E, Meddens, SFW , Beauchamp, JP & Hyppönen, E and 90 other authors and 2 consortia 2019, 'Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences', Nature Genetics, vol. 51, pp. 245-257. Open access 383 372 453
2019	Liu, X, Helenius, D, Skotte, L, Beaumont, RN, Hyppönen, E & Feenstra, B and 68 other authors 2019, 'Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration', Nature Communications, vol. 10, article no. 3927. Open access 48 35 72
2019	Lourida, I, Hannon, E, Littlejohns, TJ, Langa, KM, Hyppӧnen, E, Kuźma, E & Llewellyn, DJ 2019, 'Association of lifestyle and genetic risk with incidence of dementia', JAMA - Journal of the American Medical Association, vol. 322, no. 5 pp. 430-437. Open access 442 412 2554
2019	Melaku, YA, Renzaho, A, Gill, TK, Taylor, AW, Dal Grande, E, de Courten, B, Baye, E, Gonzalez-Chica, D, Hypponen, E, Shi, Z, Riley, M, Adams, R & Kinfu, Y 2019, 'Burden and trend of diet-related non-communicable diseases in Australia and comparison with 34 OECD countries, 1990-2015: findings from the Global Burden of Disease Study 2015', European Journal of Nutrition, vol. 58, no. 3, pp. 1299-1313. 52 47 3
2019	Mulugeta, A, Zhou, A, Vimaleswaran, KS, Dickson, C & Hypponen, E 2019, 'Depression increases the genetic susceptibility to high body mass index: evidence from UK Biobank', Depression and Anxiety, vol. 36, no. 12, pp. 1154-1162. Open access 27 27 3
2019	Ni, G, van der Werf, J, Zhou, X, Hyppönen, E, Wray, NR & Lee, SH 2019, 'Genotype-covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model', Nature Communications, vol. 10, no. 1, article no. 2239, pp. 1-15. Open access 37 34 10
2019	Schmidt, AF, Holmes, M V, Preiss, D, Swerdlow, D I, Hypponen, E & Dehghan, A and 94 other authors 2019, 'Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9', BMC Cardiovascular Disorders, vol. 19, no. 1, article no. 240, pp. 1-10. Open access 22 18 10
2019	Skaaby, T, Kilpeläinen, TO, Taylor, AE, Mahendran, Y, Zhou, A, Hyppönen, E & Linneberg, A and 40 other authors 2019, 'Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis', Addiction, vol. 114, no. 2, pp. 216-225. Open access 16 15 2
2019	Tyrrell, J, Gebremichael, A, Wood, AR, Zhou, A, Beaumont, RN, Tuke, MA, Jones, SE, Ruth, KS, Yaghootkar, H, Sharp, S, Thompson, WD, Ji, Y, Harrison, J, Freathy, RM, Murray, A, Weedon, MN, Lewis, C, Frayling, TM & Hyppӧnen, E and 1 consortium 2019, 'Using genetics to understand the causal influence of higher BMI on depression', International Journal of Epidemiology, vol. 48, no. 3, pp. 834-848. Open access 136 120 224
2019	Warrington, NM, Beaumont, RN, Horikoshi, M, Day, FR, Freathy, R & Hypponen, E 2019, 'Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors', Nature Genetics, vol. 51, no. 1, pp. 804-814. Open access 324 319 842
2019	Zhou, A & Hyppönen, E 2019, 'Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases', American Journal of Clinical Nutrition, vol. 109, no. 3, pp. 509-516. Open access 64 63 696
2019	Zhou, A, Morris, H & Hyppönen, E 2019, 'Health effects associated with serum calcium concentrations: evidence from MR-PheWAS analysis in UK Biobank', Osteoporosis International, vol. 30, no. 11, pp. 2343-2348. 18 18 1
2018	Beaumont, RN, Warrington, NM, Cavadino, A, Tyrrell, J, Hypponen, E & Freathy, RM and 80 other authors 2018, 'Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics', Human Molecular Genetics, vol. 27, no. 4, article no. ddx429, pp. 742-756. Open access 130 125 43
2018	He, Y, Timofeeva, M, Farrington, SM, Vaughan-Shaw, P, Hypponen, E & Dunlop, MG 2018, 'Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study', BMC Medicine, vol. 16, pp.1-11. Open access 57 55 12
2018	Hyppönen, E & Boucher, BJ 2018, 'Adiposity, vitamin D requirements, and clinical implications for obesity-related metabolic abnormalities', Nutrition Reviews, vol. 76, no. 9, pp. 678-692. Open access 59 56 57
2018	Jiang, X, O'Reilly, PF, Aschard, H, Hsu, Y-H, Zhou, A, Hypponen, E & Kiel, DP and 97 other authors 2018, 'Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels', Nature Communications, vol. 9, no. 1, article no. 260, pp. 1-12. Open access 287 276 60
2018	Jolliffe, DA, James, WY, Hooper, RL, Barnes, NC, Greiller, CL, Islam, K, Bhowmik, A, Timms, PM, Rajakulasingam, RK, Choudhury, AB, Simcock, DE, Hyppönen, E, Walton, RT, Corrigan, CJ, Griffiths, CJ & Martineau, AR 2018, 'Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK', The Journal of Steroid Biochemistry and Molecular Biology, vol. 175, pp. 138-145. Open access 31 31
2018	Jolliffe, DA, Kilpin, K, MacLaughlin, BD, Greiller, CL, Hooper, RL, Barnes, NC, Timms, PM, Rajakulasingam, RK, Bhowmik, A, Choudhury, AB, Simcock, DE, Hyppönen, E, Corrigan, CJ, Walton, RT, Griffiths, CJ & Martineau, AR 2018, 'Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK', The Journal of Steroid Biochemistry and Molecular Biology, vol. 175, pp. 88-96. Open access 12 15
2018	Kuźma, E, Hannon, E, Zhou, A, Lourida, I, Bethel, A, Levine, DA, Lunnon, K, Thompson-Coon, J, Hyppönen, E & Llewellyn, DJ 2018, 'Which risk factors causally influence Dementia? A systematic review of Mendelian randomization studies', Journal of Alzheimer's Disease, vol. 64, no. 1, pp. 181-193. Open access 35 37 30
2018	Lee, JJ, Wedow, R, Okbay, A, Kong, E, Cesarini, D & Hyppönen, E and 72 other authors and 3 consortia 2018, 'Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals', Nature Genetics, 50, no. 8, pp. 1112-1121. Open access 1390 1346 2118
2018	Mulugeta, A, Zhou, A, Power, C & Hyppönen, E 2018, 'Obesity and depressive symptoms in mid-life: a population-based cohort study', BMC Psychiatry, vol. 18, article no. 297. Open access 43 42 4
2018	Zhou, A, Taylor, AE, Karhunen, V, Zhan, Y & Hypponen, E and 23 other authors 2018, 'Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants', Scientific Reports, vol. 8, article no. 7526, pp. 1-9. Open access 38 35 147
2017	Berry, DJ, Dutton, J, Fraser, WD, Järvelin, M-R & Hyppönen, E 2017, 'Harmonization study between LC-MS/MS and diasorin RIA for measurement of 25-hydroxyvitamin D concentrations in a large population survey', Journal of Clinical Laboratory Analysis, vol. 31, no. 3, article no. e22049, pp. 1-10. Open access 13 14 1
2017	Berti, C, Agostoni, C, Davanzo, R, Hyppönen, E, Isolauri, E, Meltzer, HM, Steegers-Theunissen, RP & Cetin, I 2017, 'Early-life nutritional exposures and lifelong health: Immediate and long-lasting impacts of probiotics, vitamin D, and breastfeeding', Nutrition Reviews, vol. 75, no. 2, pp. 83-97. Open access 43 32 5
2017	Dale, CE, Fatemifar, G, Palmer, TM, White, J, Hyppönen, E, Zhou, A & Casas, JP and 37 other authors 2017, 'Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and type 2 diabetes mellitus: a Mendelian randomization analysis', Circulation, vol. 135, no. 24, pp. 2373-2388. Open access 265 254 116
2017	Maddock, J, Zhou, A, Cavadino, A, Kuźma, E & Hyppönen, E and 44 other authors 2017, 'Vitamin D and cognitive function: A Mendelian randomisation study', Scientific Reports, vol. 7, no. 1, article no. 13230, pp. 1-8. Open access 52 46 20
2017	Palaniswamy, S, Hyppönen, E, Williams, DM, Jokelainen, J, Lowry, E, Keinänen-Kiukaanniemi, S, Herzig, K-H, Järvelin, M-R & Sebert, S 2017, 'Potential determinants of Vitamin D in Finnish adults: A cross-sectional study from the Northern Finland birth cohort 1966', BMJ Open, vol. 7, article no. e013161, pp. 1-11. Open access 29 28 2
2017	Schmidt, AF, Swerdlow, D I, Holmes, M V, Patel, RS, Hyppönen, E, Moldovan, M & Sattar, NA and 126 other authors and 1 consortium 2017, 'PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study', The Lancet Diabetes and Endocrinology, vol. 5, no. 2, pp. 97-105. Open access 289 269 156
2017	Skaaby, T, Taylor, AE, Jacobsen, RK, Paternoster, L, Zhou, A, Hyppönen, E & Linneberg, A and 47 other authors 2017, 'Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium', Scientific Reports, vol. 7, article no. 2224, pp. 1-9. Open access 35 33 5
2017	Tripkovic, L, Wilson, LR, Hart, K, Johnsen, S, de Lusignan, S, Smith, CP, Bucca, G, Penson, S, Chope, G, Elliott, R, Hyppönen, E, Berry, JL & Lanham-New, SA 2017, 'Daily supplementation with 15 µg vitamin D₂ compared with vitamin D₃ to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial', American Journal of Clinical Nutrition, vol. 106, no. 2, pp. 481-490. Open access 83 72 162
2016	Barban, N, Jansen, R, De Vlaming, R, Vaez, A, Hyppönen, E & Mills, MC and 209 other authors 2016, 'Genome-wide analysis identifies 12 loci influencing human reproductive behavior', Nature Genetics, vol. 48, no.12, pp. 1462-1475. Open access 31 175 642
2016	Evazpoor, A, Edalati, A, Hypponen, E, Fararouei, M & Parisai, Z 2016, 'Deaths of children aged under 5 years and related factors in the Islamic Republic of Iran: a population-based case-control study', Eastern Mediterranean Health Journal, vol. 22, no. 6, pp. 368-374. Open access 6 5
2016	Felix, JF, Bradfield, JP, Monnereau, C, van der Valk, RJ, Hypponen, E & Jaddoe, VW and 107 other authors 2016, 'Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index', Human Molecular Genetics, vol. 25, no. 2, pp. 389-403. Open access 239 224 77
2016	Horikoshi, M, Beaumont, RN, Day, FR, Warrington, N, Hyppönen, E & Freathy, RM and 158 other authors 2016, 'Genome-wide associations for birth weight and correlations with adult disease', Nature, v. 538, no. 7624, pp. 248-252. Open access 334 327 332
2016	Jacobsen, R, Moldovan, M, Vaag, AA, Hypponen, E & Heitmann, BL 2016, 'Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study', Journal of Developmental Origins of Health and Disease, vol. 7, no. 1, pp. 114-119. 3 11 1
2016	Jolliffe, DA, Hanifa, Y, Witt, KD, Venton, TR, Rowe, M, Timms, PM, Hypponen, E, Walton, RT, Griffiths, CJ & Martineau, AR 2016, 'Environmental and genetic determinants of vitamin D status among older adults in London, UK', The Journal of Steroid Biochemistry and Molecular Biology, vol. 164, pp. 30-35. 31 30
2016	Larsen, SC, Ängquist, L, Moldovan, M, Huikari, V, Sebert, S, Cavadino, A, Ahluwalia, TS, Skaaby, T, Linneberg, A, Husemoen, LLN, Toft, U, Pedersen, O, Hansen, T, Herzig, K-H, Jarvelin, M-R, Power, C, Hyppönen, E, Heitman, BL & Sørensen, TI 2016, 'Serum 25-Hydroxyvitamin D status and longitudinal changes in weight and waist circumference: influence of genetic predisposition to adiposity', PLoS One, vol. 11, no. 4, article no. e0153611, pp. 1-18. Open access 8 9 1
2016	Marioni, R, Ritchie, S, Joshi, P, Hagenaars, S, Hypponen, E & Benjamin, D and 269 other authors and 1 consortia 2016, 'Genetic variants linked to education predict longevity', Proceedings of the National Academy of Sciences of USA, vol. 113, no. 47, pp. 13366-13371. Open access 54 52 124
2016	McLachlan, S, Giambartolomei, C, White, J, Charoen, P, Hypponen, E & Zabaneh, D and 40 other authors 2016, 'Replication and characterization of association between ABO SNPs and red blood cell traits by meta-analysis in Europeans', PLoS One, vol. 11, no. 6, article no. e0156914, pp. 1-18. Open access 17 16 2
2016	Munns, CF, Shaw, N, Kiely, M, Specker, BL, Hyppönen, E & Högler, W and 27 other authors 2016, 'Global consensus recommendations on prevention and management of nutritional rickets', Journal of Clinical Endocrinology and Metabolism, vol. 101, no. 2, pp. 394-415. Open access 801 44 47
2016	Nüesch, E, Dale, C, Palmer, TM, White, J, Hypponen, E & Casas, JP and 74 other authors 2016, 'Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis', International Journal of Epidemiology, vol. 45, no. 6, pp. 1927-1937. Open access 88 62 18
2016	Okbay, A, Baselmans, BM, De Neve, J-E, Turley, P, Hyppönen, E & Cesarini, D and 182 other authors 2016, 'Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses', Nature Genetics, vol. 48, no. 6, pp. 624-633. Open access 656 608 760
2016	Okbay, A, Beauchamp, JP, Fontana, MA, Lee, JJ, Hypponen, E & Benjamin, DJ and 250 other authors 2016, 'Genome-wide association study identifies 74 loci associated with educational attainment', Nature, vol. 533, pp. 539-542. Open access 826 780 1147
2016	Pappa, I, St, PB, Benke, K, Cavadino, A, Hypponen, E & Tiemeier, H and 37 other authors 2016, 'A genome-wide approach to children's aggressive behavior: The EAGLE consortium', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 171, no. 5, pp. 562-572. Open access 125 118 12
2016	Tyrrell, J, Richmond, RC, Palmer, TM, Feenstra, B, Hypponen, E & Freathy, RM and 58 others authors and 1 consortia 2016, 'Genetic evidence for causal relationships between maternal obesity-related traits and birth weight', JAMA - Journal of the American Medical Association, vol. 315, no. 11, pp. 1129-1140. Open access 191 182 415
2016	White, J, Sofat, R, Hemani, G, Shah, T, Hypponen, E & Hingorani, AD and 45 other authors and 2 consortia 2016, 'Plasma urate concentration and risk of coronary heart disease: A Mendelian randomisation analysis', The Lancet Diabetes and Endocrinology, vol. 4, no. 4, pp. 327-336. Open access 93 91 10
2016	Williams, DM, Palaniswamy, S, Sebert, S, Buxton, JL, Blakemore, AI, Hyppönen, E & Jarvelin, M-R 2016, '25-Hydroxyvitamin D concentration and leukocyte telomere length in young adults: findings from the Northern Finland Birth Cohort 1966', American Journal of Epidemiology, vol. 183, no. 3, pp. 191-198. Open access 29 27 1
2016	Zanoni, P, Khetarpal, S, Larach, D, Hancock-Cerutti, W, Rader, D & Hypponen, E and 44 other authors and 3 consortia 2016, 'Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease', Science, vol. 351, no. 6278, pp. 1166-1171. Open access 437 401 893
2015	Cornelis, M, Byrne, E, Esko, T, Nalls, M, Hyppönen, E & Chasman, D and 148 other authors and 4 consortia 2015, 'Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption', Molecular Psychiatry, vol. 20. no.5, pp. 647-656. Open access 205 193 804
2015	Holmes, M V, Asselbergs, FW, Palmer, TM, Drenos, F, Reiner, A & Hypponen, E and 55 other authors and 1 consortia (claiming author is part of the consortia) 2015, 'Mendelian randomization of blood lipids for coronary heart disease', European Heart Journal, vol. 36, no. 9, pp. 539-550. Open access 529 117
2015	Horikoshi, M, Mägi, R, van de Bunt, M, Surakka, I, Hypponen, E & Morris, AP and 76 other authors and 1 consortium 2015, 'Discovery and fine-mapping of glycaemic and obesity-related trait loci using high-density imputation', PLoS Genetics, vol. 11, no. 7, article no. e1005230. Open access 66 68 3
2015	Jacobsen, R, Hypponen, E, Sørensen, TI, Vaag, AA & Heitmann, BL 2015, 'Gestational and early infancy exposure to margarine fortified with vitamin D through a national Danish programme and the risk of type 1 diabetes: the D-tect study', PLoS One, vol. 10, no. 6, article no. e0128631, pp. 1-11. Open access 22 20 1
2015	Linneberg, A, Jacobsen, RK, Skaaby, T, Taylor, AE, Hyppönen, E & Husemoen, LLN and 54 other authors 2015, 'Effect of smoking on blood pressure and resting heart rate: a Mendelian randomization meta-analysis in the CARTA consortium', Circulation: Cardiovascular Genetics, vol. 8, no 1, pp.832-841. Open access 113 101 47
2015	Locke, AE, Kahali, B, Berndt, S I, Justice, AE, Hyppönen, ET & Speliotes, EK and 477 other authors and 13 consortia 2015, 'Genetic studies of body mass index yield new insights for obesity biology', Nature, vol. 518, pp. 197-206. Open access 3180 3056 798
2015	Maddock, J, Cavadino, A, Power, C & Hyppönen, E 2015, '25-Hydroxyvitamin D, APOE ε4 genotype and cognitive function: findings from the 1958 British birth cohort', European Journal of Clinical Nutrition, vol. 69, no. 4, pp. 505-508. Open access 26 26 12
2015	Morris, RW, Taylor, AE, Fluharty, M, Bjørngaard, J, Hypponen, E & Sattar, N and 56 other authors 2015, 'Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium', BMJ Open, vol. 5, no. 8, pp. 1-10. Open access 48 25 93
2015	Shungin, D, Winkler, TW, Croteau-Chonka, DC, Ferreira, T, Hypponen, E & Mohlke, KL and 400 other authors and 13 consortia 2015, 'New genetic loci link adipose and insulin biology to body fat distribution', Nature, vol. 518, pp. 187-196. Open access 1142 1114 407
2015	Surakka, I, Horikoshi, M, Mägi, R, Sarin, A-P, Hyppönen, E & Ripatti, S and 80 other authors and 1 consortium 2015, 'The impact of low-frequency and rare variants on lipid levels', Nature Genetics, vol. 47, no. 6, pp. 589-597. Open access 247 245 41
2015	Vimaleswaran, K, Cavadino, A, Verweij, N, Nolte, I, Leach, I, Auvinen, J, Veijola, J, Elliott, P, Penninx, B, Snieder, H, Jarvelin, M-R, Harst, Pvd, Cohen, R, Boucher, B & Hyppönen, E 2015, 'Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study', European Journal of Endocrinology, vol. 173, no. 6, pp. 863-872. Open access 8 8 2
2014	Cousminer, DL, Stergiakouli, E, Berry, DJ, Ang, W, Hyppönen, E & Widen, E and 37 other authors and 2 consortia 2014, 'Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty', Human Molecular Genetics, vol. 23, no. 16, pp. 4452-4464. Open access 74 77 2
2014	Holmes, M, Dale, CE, Zuccolo, L, Silverwood, RJ, Hypponen, ET & Casas, JP and 149 other authors and 2 consortia 2014, 'Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data', BMJ: British Medical Journal, vol. 349, article no. g4164, pp. 1-16. Open access 534 462 418
2014	Hyppönen, ET, Cavadino, A, Williams, D, Fraser, A, Vereczkey, A, Fraser, WD, Bánhidy, F, Lawlor, D & Czeizel, AE 2014, 'Vitamin D and pre-eclampsia : original data, systematic review and meta-analysis', Annals of Nutrition and Metabolism, vol. 63, no. 4, pp. 331-340. Open access 131 123 2
2014	Maddock, J, Geoffroy, M-C, Power, C & Hypponen, E 2014, '25-Hydroxyvitamin D and cognitive performance in mid-life', The British Journal of Nutrition: An International Journal of Nutritional Science, vol. 111, no. 5, pp. 904-914. Open access 23 23 1
2014	Mutt, SJ, Hyppönen, E, Saarnio, J, Järvelin, M-R & Herzig, K-H 2014, 'Vitamin D and adipose tissue-more than storage', Frontiers in Physiology, vol. 5, article no. 228, pp.1-9. Open access 150 143 40
2014	Smith, GD, Hypponen, E, Moldovan, M & Power, C 2014, 'Death of siblings in childhood and subsequent mortality: prospective observational study', European Journal of Epidemiology, vol. 29, no. 11, pp. 859-861. 2 2
2014	Taylor, A, Morris, R, Fluharty, M, Bjorngaard, J, Hypponen, E & Sattar, NA and 58 other authors 2014, 'Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with Body Mass Index in never smokers', PLoS Genetics, vol. 10, no. 12, article no. e1004799, pp. 1-6. Open access 43 44 56
2014	Taylor, AE, Fluharty, ME, Bjørngaard, JH, Gabrielsen, ME, Hypponen, E & Munafò, MR and 56 other authors 2014, 'Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium', BMJ Open, vol. 4, no. 10, article no. e006141, pp. 1-15. Open access 115 103 17
2014	Vimaleswaran, K, Power, C & Hypponen, E 2014, 'Interaction between vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D concentrations on metabolic and cardiovascular disease outcomes', Diabetes and Metabolism, vol. 40, no. 5, pp. 386-389. 26 27 1
2014	Vimaleswaran, KS, Cavadino, A, Berry, DJ, Jorde, R & Hyppönen, E and 99 other authors and 4 consortia 2014, 'Association of vitamin D status with arterial blood pressure and hypertension risk: a Mendelian randomisation study', The Lancet Diabetes and Endocrinology, vol. 2, no. 9, pp. 719-729. Open access 308 292 117
2014	Vimaleswaran, KS, Cavadino, A, Berry, DJ, Mangino, M, Andrews, P, Moore, JH, Spector, TD, Power, C, Järvelin, M-R & Hyppönen, E 2014, 'Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits', BMC Genetics, vol. 15, article no. 37, pp. 1-8. Open access 12 14
2014	Williams, DM, Fraser, A, Sayers, A, Fraser, WD, Hypponen, E, Smith, GD, Sattar, N & Lawlor, DA 2014, 'Associations of childhood 25-hydroxyvitamin D2 and D3 and cardiovascular risk factors in adolescence: prospective findings from the Avon Longitudinal Study of Parents and Children', European Journal of Preventative Cardiology, vol. 21, no. 3, pp. 281-290. Open access 25 24 1
2014	Wood, A, Esko, T, Yang, J, Vadantam, S, Hypponen, E & Frayling, T and 462 other authors 2014, 'Defining the role of common variation in the genomic and biological architecture of adult human height', Nature Genetics, vol. 46, no. 11, pp. 1173-1186. Open access 1324 1241 559
2013	Alfred, T, Ben-Shlomo, Y, Cooper, R, Hardy, R, Deary, IJ, Elliott, J, Harris, SE, Hypponen, E, Kivimaki, M, Kumari, M, Maddock, J, Power, C, Starr, JM, Kuh, D & Day, IN and 1 consortia 2013, 'Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults', Journal of Nutrition, vol. 143, no. 5, pp. 606-612. Open access 8 7
2013	Berndt, S I, Gustafsson, S, Mägi, R, Ganna, A, Lee, SH, Hyppönen, ET & Ingelsson, E and 315 other authors 2013, 'Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture', Nature Genetics, vol. 45, no. 5, pp. 501-512. Open access 485 472
2013	Berry, DJ, Hypponen, E & Cortina-Borja, M 2013, 'Investigating the association of vitamin D seasonality on inflammatory and hemostatic markers', Chronobiology International: The Journal of Biological and Medical Rhythm Research, vol. 30, no. 6, pp. 786-795. 4 4
2013	Brouwer-Brolsma, E, Bischoff-Ferrari, H, Bouillon, R, Feskens, E, Gallagher, C, Hypponen, ET, Llewellyn, D, Stoecklin, E, Dierkes, J, Kies, A, Kok, F, Lamberg-Allardt, C, Moser, U, Pilz, S, Saris, W, van Schoor, N, Weber, P, Witkamp, R, Zittermann, A & de Groot, L 2013, 'Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe', Osteoporosis International, vol. 24, no. 5, pp. 1567-1577. 96 87
2013	Cooper, R, Pinto Pereira, S, Power, C & Hypponen, E 2013, 'Parental obesity and risk factors for cardiovascular disease among their offspring in mid-life: findings from the 1958 British Birth Cohort Study', International Journal of Obesity, vol. 37, no. 12, pp. 1590-1596. Open access 26 25
2013	Cousminer, DL, Berry, DJ, Timpson, NJ, Ang, W, Hyppönen, E & Widen, E and 63 other authors and 2 consortia 2013, 'Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity', Human Molecular Genetics, vol. 22, no. 13, pp. 2735-2747. Open access 152 143
2013	Do, R, Willer, CJ, Schmidt, EM, Sengupta, S, Hyppönen, E & Kathiresan, S and 257 other authors 2013, 'Common variants associated with plasma triglycerides and risk for coronary artery disease', Nature Genetics, vol. 45, no. 11, pp. 1345-1353. Open access 686 649
2013	Fall, T, Hagg, S, Magi, R, Ploner, A, Benyamin, B, Hypponen, ET & Pokoppenko, I and 116 other authors and 2 consortia 2013, 'The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis', PLoS Medicine, vol. 10, no. 6, pp. 1-16. Open access 168 151
2013	Horikoshi, M, Yaghootkar, H, Mook-Kanamori, DO, Sovio, U, Hypponen, ET & Freathy, RM and 142 other authors 2013, 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', Nature Genetics, vol. 45, no. 1, pp. 76-82. Open access 250 242
2013	Kuan, V, Martineau, AR, Griffiths, CJ, Hyppönen, E & Walton, R 2013, 'DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes', BMC Evolutionary Biology, vol. 13, article no. 144, pp. 1-10. Open access 53 56
2013	Maddock, J, Berry, DJ, Geoffroy, M-C, Power, C & Hyppönen, E 2013, 'Vitamin D and common mental disorders in mid-life : cross-sectional and prospective findings', Clinical Nutrition, vol. 32, no. 5, pp. 758-764. 46 40
2013	Randall, JC, Winkler, TW, Kutalik, Z, Berndt, S I, Hyppönen, E & Heid, IM and 260 other authors 2013, 'Sex-stratified genome-wide association studies including 270,000 Individuals show sexual dimorphism in genetic Loci for anthropometric traits', PLoS Genetics, vol. 9, no. 6, pp. 1-19. Open access 314 312
2013	Shah, T, Engmann, J, Dale, C, Shah, S, Hypponen, E & Hingorani, AD and 38 other authors and 1 consortium 2013, 'Population genomics of cardiometabolic traits: Design of the university college London-London school of hygiene and tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium', PLoS One, vol. 8, no. 8, pp. 1-13. Open access 33 33
2013	Vimaleswaran, K, Cavadino, A & Hypponen, ET 2013, 'APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol', Atherosclerosis, vol. 228, no. 1, pp. 188-192. Open access 7 7
2013	Vimaleswaran, K, Cavadino, A, Berry, D, Whittaker, J, Power, C, Jarvelin, M & Hypponen, ET 2013, 'Genetic association analysis of vitamin D pathway with obesity traits', International Journal of Obesity, vol. 37, no. 10, pp. 1399-1406. Open access 38 39
2013	Vimaleswaran, KS, Berry, DJ, Lu, C, Tikkanen, E & Hyppönen, E and 53 other authors and 1 consortium 2013, 'Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts', PLoS Medicine, vol. 10, no. 2, pp. 1-14. Open access 758 557
2013	Willer, C, Schmidt, E, Sengupta, S, Peloso, G, Hypponen, ET & Abecasis, GR and 253 other authors 2013, 'Discovery and refinement of loci associated with lipid levels', Nature Genetics, vol. 45, no. 11, pp. 1274-1285. Open access 2226 1466
2013	Williams, D, Fraser, A, Fraser, WD, Hypponen, ET, Davey-Smith, G, Deanfield, JE, Hingorani, AD, Sattar, NA & Lawlor, DA 2013, 'Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: Findings from the avon longitudinal study of parents and children', Heart, vol. 99, no. 24, pp. 1849-1856. Open access 37 30
2012	Angelakopoulou, A, Shah, T, Sofat, R, Shah, S, Hypponen, E & Hingorani, AD and 39 other authors 2012, 'Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration', European Heart Journal, vol. 33, no. 3, pp. 393-407. Open access 92 87
2012	Berry, DJ, Vimaleswaran, KS, Whittaker, JC, Hingorani, AD & Hyppönen , E 2012, 'Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D', PLoS One, vol. 7, no. 5. Open access 80 76
2012	Bradfield, JP, Taal, HR, Timpson, NJ, Scherag, A, Hypponen, ET & Grant, SF and 75 other authors and 1 consortium 2012, 'A genome-wide association meta-analysis identifies new childhood obesity loci.', Nature Genetics, vol. 44, no. 5, pp. 526-531. Open access 303 289
2012	Disanto, G, Chaplin, G, Morahan, JM, Giovannoni, G, Hyppönen, E, Ebers, GC & Ramagopalan, S V 2012, 'Month of birth, vitamin D and risk of immune-mediated disease: a case control study', BMC Medicine, vol. 10, article no. 69, pp. 1-7. Open access 114 106
2012	Ikram, MA, Fornage, M, Smith, A V, Seshadri, S, Hypponen, ET & Wilson, JF and 122 other authors and 2 consortia 2012, 'Common variants at 6q22 and 17q21 are associated with intracranial volume', Nature Genetics, vol. 44, no. 5, pp. 539-544. Open access 96 109
2012	Mutt, SJ, Karhu, T, Lehtonen, S, Lehenkari, P, Carlberg, C, Saarnio, J, Sebert, S, Hyppönen, E, Järvelin, M-R & Herzig, K-H 2012, 'Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-KB pathway', The FASEB Journal, vol. 26, no. 11, pp. 4400-4407. 74 72
2012	Taal, HR, St Pourcain, B, Thiering, E, Das, S, Jaddo, VW & Hypponen, E and 80 other authors and 3 consortia 2012, 'Common variants at 12q15 and 12q24 are associated with infant head circumference', Nature Genetics, vol. 44, no. 5, pp. 532-538. Open access 94 97
2012	Tripkovic, L, Lambert, H, Hart, K, Smith, CP, Bucca, G, Penson, S, Chope, G, Hyppon̈en, E, Berry, J, Vieth, R & Lanham-New, S 2012, 'Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis', American Journal of Clinical Nutrition, vol. 95, no. 6, pp. 1357-1364. Open access 579 527
2012	Tyrell, J, Huikari, V, Christie, JT, Cavadino, A, Bakker, R, Brion, MJA, Geller, F, Paternoster, L, Myhre, R, Potter, C, Johnson, PC, Ebrahim, S, Feenstra, B, Hartikainen, AL, Hattersley, AT, Hofman, A, Kaakinen, M, Lowe, LP, Magnus, P, McConnachie, A, Melbye, M, Ng, JW, Nohr, EA, Power, C, Ring, SM, Sebert, SP, Sengpiel, V, Taal, HR, Watt, GC, Sattar, N, Relton, CL, Jacobsson, B, Frayling, TM, Sørensen, TI, Murray, JC, Lawlor, DA, Pennell, CE, Jaddoe, VW, Hypponen, ET, Lowe, WL Jr, Jarvelin, M-R, Smith, GD & Freathy, RM and 1 consortium 2012, 'Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight', Human Molecular Genetics, vol. 21, no. 24, pp. 5344-5358. Open access 56 56
2012	Vimaleswaran, K, Cavadino, A & Hypponen, E 2012, 'Evidence for a genetic interaction in allergy-related responsiveness to vitamin D deficiency', Allergy: European Journal of Allergy and Clinical Immunology, vol. 67, no. 8, pp. 1033-1040. 20 20
2011	Berry, D & Hypponen, E 2011, 'Determinants of vitamin D status: focus on genetic variations', Current Opinion in Nephrology and Hypertension, vol. 20, no. 4, pp. 331-336. 81 74
2011	Berry, DJ, Hesketh, K, Power, C & Hypponen, ET 2011, 'Vitamin D status has a linear association with seasonal infections and lung function in British adults', The British Journal of Nutrition: An International Journal of Nutritional Science, vol. 106, no. 9, pp. 1433-1440. Open access 214 152
2011	Chambers, JC, Zhang, W, Sehmi, J, Li, X, Hypponen, E & Kooner, JS and 137 other authors 2011, 'Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma', Nature Genetics, vol. 43, no. 11, pp. 1131-1138. Open access 245 429
2011	Cooper, JD, Smyth, DJ, Walker, NM, Stevens, H, Burren, OS, Wallace, C, Greissl, C, Ramos-Lopez, E, Hypponen, ET, Dunger, DB, Spector, TD, Ouwehand, WH, Wang, TJ, Badenboop, K & Todd, JA 2011, 'Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes', Diabetes, vol. 60, no. 5, pp. 1624-1631. Open access 236 216
2011	Disanto, G, Handel, A, Morahan, J, Deluca, G, Kimball, S, Hypponen, E, Giovannoni, G, Ebers, G & Ramagopalan, S 2011, 'Vitamin D and multiple sclerosis hospital admissions in Scotland', QJM: an international journal of medicine, vol. 104, no. 11, pp. 1001-1003. Open access 7 5
2011	Hypponen, E, Fararouei, M, Sovio, U, Hartikainen, A, Pouta, A, Robertson, C, Whittaker, JC & Jarvelin, M 2011, 'High-dose vitamin D supplements are not associated with linear growth in a large Finnish cohort', Journal of Nutrition, vol. 141, no. 5, pp. 843-848. Open access 17 16
2011	Hypponen, ET 2011, 'Preventing vitamin D deficiency in pregnancy - importance for the mother and child', Annals of Nutrition and Metabolism, vol. 59, no. 1, pp. 28-31. 31 27
2011	Kilpeläinen, TO, Qi, L, Brage, S, Sharp, SJ, Hypponen, E & Loos, RJ and 110 other authors 2011, 'Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children', PLoS Medicine, vol. 8, no. 11, pp. 1-15. Open access 440 402
2011	Kilpeläinen, TO, den Hoed, M, Ong, KK, Grøntved, A, Hypponen, E & Loos, RJ and 88 other authors 2011, 'Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals', American Journal of Clinical Nutrition, vol. 93, no. 4, pp. 851-860. Open access 53 50
2011	Lanham-New, SA, Buttriss, JL, Miles, LM, Ashwell, M, Hyppöpnen, E & Williams, CM and 19 other authors 2011, 'Proceedings of the rank forum on vitamin D', The British Journal of Nutrition: An International Journal of Nutritional Science, v. 105, no. 1, pp. 144-156. Open access 83
2011	Ward, M, Berry, DJ, Power, C & Hyppönen, E 2011, 'Working patterns and vitamin D status in mid-life: a cross-sectional study of the 1958 British birth cohort', Occupational and Environmental Medicine, vol. 68, no. 12, pp. 902-907. 32 30
2011	Zabaneh, D, Gaunt, TR, Kumari, M, Drenos, F, Hypponen, E & Humphries, SE and 22 other authors 2011, 'Genetic variants associated with von Willebrand factor levels in healthy men and women Identified using the HumanCVD BeadChip', Annals of Human Genetics, vol. 75, no. 4, pp. 456-467. 27 25
2010	Chambers, JC, Zhang, W, Lord, GM, Van der Harst, P, Hypponen, E & Kooner, JS and 88 other authors 2010, 'Genetic loci influencing kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 373-375. Open access 241 223
2010	Cooper, R, Hypponen, E, Berry, D & Power, C 2010, 'Associations between parental and offspring adiposity up to midlife: the contribution of adult lifestyle factors in the 1958 british birth cohort study', American Journal of Clinical Nutrition, vol. 92, no. 4, pp. 946-953. Open access 64 61
2010	Fararouei, M, Robertson, C, Whittaker, J, Sovio, U, Ruokonen, A, Hartikainen, A-L, Jarvelin, M-R & Hypponen, E 2010, 'Maternal Hb during pregnancy and offspring's educational achievement: a prospective cohort study over 30 years', The British Journal of Nutrition: An International Journal of Nutritional Science, vol. 104, no. 9, pp. 1363-1368. Open access 16 16
2010	Freathy, RM, Mook-Kanamori, DO, Sovio, U, Prokopenko, I, Hypponen, E & McCarthy, M I and 80 other authors 2010, 'Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight', Nature Genetics, vol. 42, no. 5, pp. 430-435. Open access 199 191
2010	Harville, EW, Boynton-Jarrett, R, Power, C & Hypponen, E 2010, 'Childhood hardship, maternal smoking, and birth outcomes: a prospective cohort study', JAMA Pediatrics, vol. 164, no. 6, pp. 533-539. Open access 51 50
2010	Hypponen, E & Boucher, BJ 2010, 'Avoidance of vitamin D deficiency in pregnancy in the United Kingdom: the case for a unified approach in National policy', The British Journal of Nutrition: An International Journal of Nutritional Science, vol. 104, no. 3, pp. 309-314. Open access 53 48
2010	Hyppönen, E 2010, 'Vitamin D and increasing incidence of type 1 diabetes - evidence for an association?', Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, vol. 12, no. 9, pp. 737-743. 69 63
2010	Power, C, Cortina-Borja, M, Hypponen, ET & Berry, DJ 2010, '25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: A cross sectional analysis in the 1958 british birth cohort', PLoS One, vol. 5, no. 5, article no. e10801, pp. 1-8. Open access 89 82
2010	Wang, T, Zhang, F, Richards, JB, Kestenbaum, B, Hypponen, E & Spector, TD and 70 other authors 2010, 'Common genetic determinants of vitamin D insufficiency : a genome-wide association study', The Lancet, vol. 376, no. 9736, pp. 180-188. Open access 1358 1247
2009	Atherton, K, Berry, D, Parsons, T, Macfarlane, G, Power, C & Hyppönen, E 2009, 'Vitamin D and chronic widespread pain in a white middle-aged British population: Evidence from a cross-sectional population survey', Annals of the Rheumatic Diseases, vol. 68, no. 6, pp. 817-822. 116 103
2009	Freathy, RM, Bennett, AJ, Ring, SM, Shields, B, Hypponen, E & Hattersley, AT and 16 other authors 2009, 'Type 2 diabetes risk alleles are associated with reduced size at birth', Diabetes, vol. 58, no. 6, pp. 1428-1433. Open access 117 106
2009	Hyppönen, E, Berry, D, Wjst, M & Power, C 2009, 'Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship', Allergy: European Journal of Allergy and Clinical Immunology, vol. 64, no. 4, pp. 613-620. Open access 210 197
2008	Hypponen, E, Boucher, BJ, Berry, DJ & Power, C 2008, '25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British birth cohort', Diabetes, vol. 57, no. 2, pp. 298-305. Open access 328 307
2008	Hypponen, ET 2008, 'Birth weight and risk of type 2 diabetes a systematic review', JAMA - Journal of the American Medical Association, vol. 300, no. 24, pp. 2886-2897. 783 302
2008	Thomas, C, Hyppönen, E & Power, C 2008, 'Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity', Pediatrics, vol. 121, no. 5, pp. 1240-1249. 279 256

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Aarhus University	DENMARK
Amtssygehuset i Gentofte	DENMARK
Ashwell Associates	UNITED KINGDOM
Barts and London School of Medicine and Dentistry	UNITED KINGDOM
BHF Glasgow Cardiovascular Research Centre	UNITED KINGDOM
Birmingham Children's Hospital	UNITED KINGDOM
Bispebjerg and Frederiksberg Hospitals	DENMARK
Bispebjerg Hospital	DENMARK
Blizard Institute	UNITED KINGDOM
Boston Children’s Hospital	UNITED STATES
Boston Children's Hospital	UNITED STATES
Boston University	UNITED STATES
British Nutrition Foundation	UNITED KINGDOM
Brunel University London	UNITED KINGDOM
Campden BRI	UNITED KINGDOM
Cancer Voices	AUSTRALIA
Catholic University of Leuven	BELGIUM
Centre for Paediatric Epidemiology and Biostatistics	UNITED KINGDOM
Childrens Hospital of Phiadelphia	UNITED STATES
Childrens Hospital of Philadelphia	UNITED STATES
Children's Hospital of Philadelphia	UNITED STATES
Churchill Hospital	UNITED KINGDOM
Copenhagen University Hospital	DENMARK
Creighton Endocrinology	UNITED STATES
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Dartmouth College	UNITED STATES
Deakin University	AUSTRALIA
deCODE genetics	ICELAND
DSM Biotechnology Center	NETHERLANDS
DSM Nutritional Products	UNITED STATES
Erasmus MC	NETHERLANDS
Erasmus MC, Rotterdam	NETHERLANDS
Erasmus University Medical Centre	NETHERLANDS
Erasmus University Rotterdam	NETHERLANDS
Flinders Medical Centre	AUSTRALIA
Foundation for the Community Control of Hereditary Diseases	HUNGARY
Fred Hutchinson/University of Washington Cancer Consortium	UNITED STATES
Free University of Amsterdam	NETHERLANDS
Fudan University	CHINA
Gerash University of Medical Sciences	IRAN
German Research Center for Environmental Health	GERMANY
Griffith University	AUSTRALIA
Groningen Research Institute for Asthma and COPD	NETHERLANDS
Harborview Medical Center, United States	AUSTRALIA
Harvard School of Public Health	UNITED STATES
Harvard TH Chan School of Public Health	UNITED STATES
Harvard University	UNITED STATES
Helmholtz Centre for Environmental Research - UFZ	GERMANY
Homerton University Hospital NHS Foundation Trust	UNITED KINGDOM
Icahn School of Medicine at Mount Sinai	UNITED STATES
Imperial College of Science, Technology and Medicine	UNITED KINGDOM
Institut for Sygdomsforebyggelse	DENMARK
Institute for Molecular Medicine Finland	FINLAND
Institute of Child Health	INDIA
Institute of Child Health London	UNITED KINGDOM
Institute of Health Sciences	BRAZIL
Institute of Metabolic Science	UNITED KINGDOM
iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research	DENMARK
IRCCS Foundation	ITALY
Isfahan University of Medical Sciences	IRAN
Islamic Azad University	IRAN
Johns Hopkins University	UNITED STATES
Karolinska Institute	SWEDEN
Karolinska Institutet Innovations (Sweden)	SWEDEN
King's College London	UNITED KINGDOM
Kings College, VIC	AUSTRALIA
Kuopio University Hospital	FINLAND
Leiden University	NETHERLANDS
London School of Hygiene and Tropical Medicine	UNITED KINGDOM
Loughborough University	UNITED KINGDOM
Max Planck Institute for Psycholinguistics	NETHERLANDS
McGill University	CANADA
McMaster University	CANADA
Medical Research Council	UNITED KINGDOM
Medical University of Graz	AUSTRIA
Monash University	AUSTRALIA
MRC Biostatistics Unit	UNITED KINGDOM
Murdoch Childrens Research Institute	AUSTRALIA
National Institute for Health and Welfare	FINLAND
National Institutes of Health	MALAYSIA
New York University	UNITED STATES
Newcastle University, United Kingdom	UNITED KINGDOM
Northwestern University	UNITED STATES
Northwestern University Feinberg School of Medicine	UNITED STATES
Norwegian Institute of Public Health	NORWAY
Norwegian University of Science and Technology	NORWAY
Oulu University Hospital	FINLAND
Oulun Yliopisto	FINLAND
Oxford University	UNITED KINGDOM
Peking University	CHINA
Peking University Health Science Centre	CHINA
Peninsula Medical School	UNITED KINGDOM
Pennsylvania State University	UNITED STATES
Poznan University of Medical Sciences	POLAND
Private Individual	UNITED KINGDOM
Queen Mary School	UNITED KINGDOM
Queen Mary University of London	UNITED KINGDOM
Queen's Hospital	UNITED KINGDOM
Research Centre for Prevention and Health	DENMARK
Royal Adelaide Hospital	AUSTRALIA
Royal Alexandra Hospital for Children	AUSTRALIA
Royal Liverpool University Hospital	UNITED KINGDOM
Royal London Hospital	UNITED KINGDOM
Ruhr University Bochum	GERMANY
Sahlgrenska Universitetssjukhuset	SWEDEN
School of Hygiene and Tropical Medicine	UNITED KINGDOM
Semmelweis University	HUNGARY
Shanghai Jiao Tong University	CHINA
Shiraz University	IRAN
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
South Dakota State University	UNITED STATES
Southern Cross University	AUSTRALIA
State Serum Institute (Denmark)	DENMARK
Statens Seruminstitut	DENMARK
Tampere University	FINLAND
Tehran University of Medical Sciences	IRAN
The Children's Hospital of Philadelphia	UNITED STATES
Tulane University	UNITED STATES
UCL Great Ormond Street Institute of Child Health	UNITED KINGDOM
UCL Institute of Child Health	UNITED KINGDOM
Umea University	SWEDEN
Universitat Pompeu Fabra	SPAIN
University College Cork	IRELAND
University College Hospital	UNITED KINGDOM
University College London	UNITED KINGDOM
University College London Institute of Child Health	UNITED KINGDOM
University Hospital Frankfurt	GERMANY
University Hospital of Zurich	SWITZERLAND
University Medical Center, Rotterdam	NETHERLANDS
University of Aberdeen	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Bergen	NORWAY
University of Birmingham	UNITED KINGDOM
University of Bologna	ITALY
University of Brighton	UNITED KINGDOM
University of Bristol	UNITED KINGDOM
University of California System	UNITED STATES
University of Cambridge	UNITED KINGDOM
University of Canberra	AUSTRALIA
University of Colorado Denver	UNITED STATES
University of Copenhagen	DENMARK
University of Duisburg-Essen	GERMANY
University of East Anglia	UNITED KINGDOM
University of Eastern Finland	FINLAND
University of Edinburgh	UNITED KINGDOM
University of Exeter	UNITED KINGDOM
University of Glasgow	UNITED KINGDOM
University of Gothenburg	SWEDEN
University of Groningen	NETHERLANDS
University of Hamburg	GERMANY
University of Helsinki	FINLAND
University of Iceland	ICELAND
University of Ioannina	GREECE
University of Lausanne	SWITZERLAND
University of Liverpool	UNITED KINGDOM
University of Manchester	UNITED KINGDOM
University of Michigan	UNITED STATES
University of Milan	ITALY
University of Minnesota, Twin Cities	UNITED STATES
University of New England	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Oklahoma Health Sciences Center	UNITED STATES
University of Oulu	FINLAND
University of Oxford	UNITED KINGDOM
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of Reading	UNITED KINGDOM
University of Regensburg	GERMANY
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Southern Denmark	DENMARK
University of Surrey	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Tampere	FINLAND
University of Tartu	ESTONIA
University of Texas	UNITED STATES
University of Toronto	CANADA
University of Tromsø	NORWAY
University of Turku	FINLAND
University of Wageningen	NETHERLANDS
University of Warwick	UNITED KINGDOM
University of Washington	UNITED STATES
University of Western Australia	AUSTRALIA
University of Westminster	UNITED KINGDOM
University of Zurich	SWITZERLAND
Uppsala University	SWEDEN
Versys Clinics, Human Reproduction Institute	HUNGARY
Vrije University	NETHERLANDS
VU University Medical Center	NETHERLANDS
Wellcome Centre for Human Genetics	UNITED KINGDOM
Wellcome Trust Sanger Institute	UNITED KINGDOM
Western Sydney University	AUSTRALIA
Yasuj University of Medical Sciences	IRAN

External engagement & recognition

Engagement/recognition	Year
Adjunct Professor in Epidemiology University of Tampere, Finland	2017
Honorary Professor University College London	2017
Principal Research Fellow South Australian Health and Medical Research Institute (SAHMRI)	2017
Project Grant: The dark side of vitamin D supplementation National Health and Medical Research Council (NHMRC)	2017
Project Grant National Health and Medical Research Council (NHMRC)	2016

Teaching & student supervision

Highlights

Course co-ordinator for "Health Data Sources and Management" (HLTH5190)

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Application of statistical genomic methods to tackle heterogeneity in psychiatric diseases	Current
Dissecting the genetic and environmental factors affecting stunting	Current
Elucidating the role of inflammation in psychiatric disorders	Current
Exploring the Genetic Association between Cardiometabolic Abnormalities in Clozapine in Treatment-Resistant Schizophrenia	Current
Improving genetic prediction of ovarian cancer risk	Current
Integrative analyses of omics data for complex traits and diseases	Current
Investigation of alcohol use and its consequences on human health	Current
Nutritional genomics and neurological disease (epilepsy)	Current
Predicting brain health and dementia: a machine learning approach	Current
Unraveling the link between blood proteins biomarkers and the risk of depression: a large-scale data-driven study	Current
Vitamin D and degenerative health: a large-scale study exploring deficiency, muscle traits, mortality, and fall risk using data sourced from the UK Biobank.	Current
Data-driven analysis to establish the role of adiposity and related metabolic abnormalities on cancer: a large-scale study using the UK Biobank	Completed
Exploring the effects of serum lipids, cholesterol lowering medications and coffee on health: observational and genetic studies	Completed
Machine learning for predictive modelling and risk factor discovery in health and wealth	Completed
Pain and depression: exploring gene-environment interactions and the role of stress	Completed
Physical activity, APOE genotype and cognitive function: exploring gene-environment interactions in the UK Biobank	Completed
Relationship between obesity and depression: evidence from observational and genetic studies	Completed

Professor Elina Hypponen

Alternative contact

Alternative contact details

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Other projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Adjunct Professor in Epidemiology

Honorary Professor

Principal Research Fellow

Project Grant: The dark side of vitamin D supplementation

Project Grant

Teaching & student supervision

Highlights

Courses and programs

Courses I teach

Research degree supervision

Gallery