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Dr Emma Parkinson-Lawrence

  • Program Director: Medical Sciences School of Pharmacy and Medical Sciences
  • City East Campus (P4-06)
  • tel +61 8 830 22650
  • email Emma.Parkinson-Lawrence@unisa.edu.au
  • Available for media comment
  • Research Degree Supervisor
  • About me
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About me

About me

Dr Emma Parkinson-Lawrence

Having been trained as a Biochemist and establishing a strong desire to work in the area of protein dysfunction and disease pathogenesis I was fortunate to obtain a research position in the Lysosomal Diseases Research Unit at the Women’s in Children’s Hospital. I became involved in research to understand the molecular mechanisms of lysosomal disease pathogenesis and developed diagnostic assays. During this time, I became particularly interested in the neurological dysfunction associated with these diseases, in particular Sanfilippo Syndrome, and commenced a research program looking at the role of altered neurotransmission and disease progression, having been awarded an NHMRC Peter Doherty Early Career Research Fellowship. At... Read more

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  • Scopus
  • ResearcherID
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About me

Having been trained as a Biochemist and establishing a strong desire to work in the area of protein dysfunction and disease pathogenesis I was fortunate to obtain a research position in the Lysosomal Diseases Research Unit at the Women’s in Children’s Hospital. I became involved in research to understand the molecular mechanisms of lysosomal disease pathogenesis and developed diagnostic assays. During this time, I became particularly interested in the neurological dysfunction associated with these diseases, in particular Sanfilippo Syndrome, and commenced a research program looking at the role of altered neurotransmission and disease progression, having been awarded an NHMRC Peter Doherty Early Career Research Fellowship. At the completion of my fellowship I obtained a research-teaching academic position at the University of South Australia.

Serendipity and discussions with Professor Sandra Orgeig have evoked a new research program investigating the molecular mechanisms that may impact respiratory dysfunction in Sanfilippo Syndrome but may also contribute to other lysosomal diseases; underlying molecular mechanisms contributing to both neurological and respiratory dysfunction. This includes a continuing collaboration with Associate Kim Hemsley (Flinders University) and co supervision of PhD students. During my research career thus far, I have had the privilege to attend and present our research findings at several international MPS and related disease conferences and interacted with many amazing patients and their families, clinicians and scientists. This truly reinforces to me why I continue to do what I do.

As a senior scientist in the Mechanisms in Cell Biology and Disease research group I am also been involved in projects focussed on the endosome-lysosome system and cancer pathogenesis.

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Professional Associations

The Australian Society for Medical Research (ASMR),Autralian Society for Biochemistry and Molecular Biology (ASBMB),ASBMB Adelaide Protein Group
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Experience

Qualifications

  • Doctor of Philosophy The University of Adelaide

  • Bachelor of Science (Honours) The University of Adelaide

  • Bachelor of Science The University of Adelaide

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  • About me
  • Professional associations
  • Experience
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Research

Research themes

  • Cancer
  • Healthy futures

Research focus

  • Clinical Sciences
  • Medical and Health Sciences
  • Biological Sciences
  • Neurosciences
  • Biochemistry and Cell Biology

Highlights

Movement/traffic of proteins and organelles within the intracellular environment; particularly neurons,Protein structure and function
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Research

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Projects

Excludes commercial-in-confidence projects.

  • Diagnostic and prognostic biomarker test for prostate cancer, EnVision Sciences Pty Ltd, 01/01/2017 - 30/10/2018

  • Lung function in a mouse model of a paediatric metabolic mouse, The Australian Lung Foundation, 01/05/2016 - 05/03/2018

  • Defining altered endosome-lysosome biogenesis in breast cancer to aid in the identification of early diagnostic and prognostic biomarkers, NBCF - Investigator Initiated Research Scheme, 01/01/2013 - 30/06/2015

  • Development of a gene delivery system to access neuronal cells, ARC - Linkage Project, 01/07/2008 - 30/06/2011

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Outputs

Research since 2008 is shown below. To see earlier years visit ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year Output
2014

Kamei, M, Kasperski, K, Fuller, M, Parkinson-Lawrence, EJ, Karageorgos, L, Belakhov, V, Aasov, T, Hopwood, JJ & Brooks, DA 2014, 'Aminoglycoside-induced premature stop codon read-through of mucopolysaccharidosis type I patient Q70X and W402X mutations in cultured cells', in J Zschocke et al. (eds), JIMD reports - case and research reports, Springer, US, vol. 13, pp.139-147.

Open access 10 4 1
2012

Shandala, T, R Kakavanos-Plew, Ng, Y, Bader, CA, Sorvina, A, Parkinson-Lawrence, E, Brooks, RD, Borlace, G, Prodoehl, M & Brooks, D 2012, 'Molecular machinery regulating exocytosis', in R Weigert (ed.), Crosstalk and integration of membrane trafficking pathways, InTech, Croatia, ch. 4, pp. 61-108.

Open access

Journal Articles

Year Output
2019

Paget, TL, Parkinson-Lawrence, EJ & Orgeig, S 2019, 'Interstitial lung disease and surfactant dysfunction as a secondary manifestation of disease: insights from lysosomal storage disorders', Drug Discovery Today: Disease Models, online, pp. 1-8.

2019

Visalakshan, RM, Cavallaro, AA, MacGregor, MN, Lawrence, EP, Koynov, K, Hayball, JD & Vasilev, K 2019, 'Nanotopography-induced unfolding of fibrinogen modulates leukocyte binding and activation', Advanced Functional Materials, vol. 29, no. 14, article no.1807453, pp. 1-12.

2 2 2
2019

Yazbeck, R, Jaenisch, S, Squire, M, Abbott, CA, Parkinson-Lawrence, E, Brooks, DA & Butler, RN 2019, 'Development of a ¹³C stable isotope assay for dipeptidyl peptidase-4 enzyme activity a new breath test for dipeptidyl peptidase activity', Scientific Reports, vol. 9, article no. 4906, pp. 1-9.

Open access 1 1 71
2018

Sorvina, A, Bader, CA, Caporale, C, Carter, EA, Johnson, IR, Parkinson-Lawrence, EJ, Simpson, P V, Wright, PJ, Stagni, S, Lay, PA, Massi, M, Brooks, DA & Plush, SE 2018, 'Lipid profiles of prostate cancer cells', Oncotarget, vol. 9, no. 85, pp. 35541-35552.

Open access 1 6
2017

Beard, H, Hassiotis, S, Gai, W-P, Parkinson-Lawrence, E, Hopwood, JJ & Hemsley, KM 2017, 'Axonal dystrophy in the brain of mice with Sanfilippo syndrome', Experimental Neurology, vol. 295, pp. 243-255.

7 4 1
2015

Johnson, IR, Parkinson-Lawrence, EJ, Keegan, H, Spillane, CD, Barry-O'Crowley, J, Watson, WR, Selemidis, S, Butler, LM, O'Leary, JJ & Brooks, DA 2015, 'Endosomal gene expression: A new indicator for prostate cancer patient prognosis?', Oncotarget, vol. 6, no.35, pp..

Open access 13 11 5
2014

Johnson, IR, Parkinson-Lawrence, EJ, Butler, LM & Brooks, DA 2014, 'Prostate cell lines as models for biomarker discovery: performance of current markers and the search for new biomarkers', Prostate, vol. 74, no. 5, pp. 547-560.

7 6 1
2014

Johnson, IR, Parkinson-Lawrence, EJ, Shandala, T, Weigert, R, Butler, LM & Brooks, DA 2014, 'Altered endosome biogenesis in prostate cancer has biomarker potential', Molecular Cancer Research, vol. 12, no. 12, pp. 1851-1862.

Open access 11 12 5
2012

Keating, D, Winter, M, Hemsley, K, Mackenzie, K, Teo, E, Hopwood, J, Brooks, D & Parkinson-Lawrence, E 2012, 'Exocytosis is impaired in mucopolysaccharidosis IIIA mouse chromaffin cells', Neuroscience, vol. 227, no. 27, pp. 110-118.

10 10
2012

Ponder, KP, O'Malley, TM, Wang, P, O'Donnell, PA, Traas, AM, Knox, VW, Aguirre, GA, Ellinwood, NM, Metcalf, JA, Wang, B, Parkinson-Lawrence, EJ, Sleeper, MM, Brooks, DA, Hopwood, JJ & Haskins, ME 2012, 'Neonatal gene therapy with a gamma retroviral vector in mucopolysaccharidosis VI cats', Molecular Therapy, vol. 20, no. 5, pp. 898-907.

Open access 17 18 1
2012

Yazbeck, R, Dawson, P, Rogers, N, West, C, Keogh, R, Wallace, D, Polyak, S, Nowak, K, Burt, R, Taylor, J, Dunn, L, Philp, A & Parkinson-Lawrence, E 2012, 'Indigenous health: action on prevention - 50th annual Australian society for medical research national scientific conference', Rural and Remote Health, vol. 12, no. 3, pp. 1-5.

Open access
2010

Parkinson-Lawrence, EJ, Shandala, T, Prodoehl, MJR, Plew, R, Borlace, GN & Brooks, DA 2010, 'Lysosomal storage disease: revealing lysosomal function and physiology', Physiology, vol. 25, no. 2, pp. 102-115.

111 107 4
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Research

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Current research & highlights

Movement/traffic of proteins and organelles within the intracellular environment; particularly neurons,Protein structure and function
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Research

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Patents

Details Registry Status

Methods for detecting prostate cancer

Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto

AU Filed

Methods for detecting prostate cancer

Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto

EP Filed

Methods for detecting prostate cancer

Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto

SG Filed

Methods for detecting prostate cancer

Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto

US Filed

Methods for detecting prostate cancer

Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto

WO Filed
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  • Projects
  • Outputs
  • Current research & highlights
  • Patents
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External engagement & recognition

Collaborations

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External engagement & recognition

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Collaborations

Organisation Country
Australian Society of Medical Research AUSTRALIA
Central Queensland University AUSTRALIA
Childrens Cancer Institute Australia for Medical Research AUSTRALIA
Complutense University of Madrid SPAIN
Coombe Women and Infants University Hospital IRELAND
Curtin University AUSTRALIA
Flinders University AUSTRALIA
Heart Research Institute UNITED STATES
Institute of Medical and Veterinary Science AUSTRALIA
Mater Medical Research Institute AUSTRALIA
Max Planck Institute for Polymer Research GERMANY
Monash University AUSTRALIA
Murdoch Childrens Research Institute AUSTRALIA
NIDCR UNITED STATES
Queensland Institute of Medical Research AUSTRALIA
Royal Women's Hospital AUSTRALIA
SA Pathology AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI) AUSTRALIA
Technion Israel Institute of Technology ISRAEL
University College Dublin IRELAND
University of Adelaide AUSTRALIA
University of Bologna ITALY
University of Dublin IRELAND
University of Melbourne AUSTRALIA
University of Pennsylvania UNITED STATES
University of South Australia AUSTRALIA
University of Southampton UNITED KINGDOM
University of Sydney AUSTRALIA
University of Technology Sydney AUSTRALIA
University of Washington UNITED STATES
University of Western Australia AUSTRALIA
Women's and Children's Health Network AUSTRALIA
Women's and Children's Hospital AUSTRALIA
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External engagement & recognition

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External engagement & recognition

Engagement/recognition Year

Member

Australian Society for Medical Research (ASMR)

2018

Member

Australian Society for Biochemistry and Molecular Biology (ASBMB)

2018

Member, Adelaide Protein Group

Australian Society for Biochemistry and Molecular Biology (ASBMB)

2018

Member

Australian Society for Medical Research (ASMR)

2017

Member

Australian Society for Biochemistry and Molecular Biology (ASBMB)

2017

Member, Adelaide Protein Group

Australian Society for Biochemistry and Molecular Biology (ASBMB)

2017
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Teaching & student supervision

Highlights

Cell Biology,Protein Structure and Function
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Teaching & student supervision

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Courses and programs

Courses I teach and/or co-ordinate

  • BIOL 2035 Physiology (2020)
  • BIOL 2035 Physiology (2019)
  • BIOL 2035 Physiology (2018)
  • BIOL 1050 Human Physiology 101 (2020)
  • BIOL 1050 Human Physiology 101 (2019)
  • BIOL 1050 Human Physiology 101 (2018)
  • BIOL 1049 Human Physiology 100 (2020)
  • BIOL 1049 Human Physiology 100 (2019)
  • BIOL 1049 Human Physiology 100 (2018)
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Teaching & student supervision

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Research degree supervision

Supervisions from 2010 shown

Thesis title Student status
Altered pulmonary surfactant biogenesis and secretion in the Mucopolysaccharidoses: a common mechanism of respiratory dysfunction in lysosomal storage disorders? Current
Altered lysosomal biogenesis in prostate cancer Completed
Development of targeted luminescent metal complexes for cellular imaging Completed
The role of endosomes in innate immunity Completed
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Gallery

Dr Emma Parkinson-Lawrence
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