Dr Ian Johnson

Adjunct Senior Research Fellow UniSA Clinical & Health Sciences

email Ian.Johnson@unisa.edu.au

Research Degree Supervisor

About me

Vesicular trafficking
Prostate cancer
Disease biomarkers
Endosomes & lysosomes
Space biomedicine

Dr. Ian Johnson is an Adjunct Senior Research Fellow at UniSA Clinical & Health Sciences and the Senior Coordinator for Life Sciences at Telespazio, working with the European Space Agency.

With a robust research background in vesicular trafficking mechanisms of prostate cancer, monoclonal antibody development, and the effects of microgravity on cellular physiology and disease pathogenesis, Dr. Johnson is dedicated to advancing the diagnosis, prognosis, and treatment of diseases by identifying new biomarkers of altered cellular processes.

Dr. Johnson has authored over 30 peer-reviewed articles, holds patents for cancer detection methods, and serves as a reviewer and guest editor for various scientific journals.

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UniSA Clinical & Health Sciences

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Research

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Oncology and Carcinogenesis
Other Biological Sciences
Analytical Chemistry

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2024	Nturubika, BD, Guardia, CM, Gershlick, DC, Logan, JM, Martino, C, Heatlie, JK, Lazniewska, J, Moore, C, Lam, GT, Li, KL, Ung, BS-Y, Brooks, RD, Hickey, SM, Bert, AG, Gregory, PA, Butler, LM, O'Leary, JJ, Brooks, DA & Johnson, IRD 2024, 'Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression', British Journal of Cancer, vol. 131, no. 8, pp. 1263-1278. Open access 2 2
2023	Cortés-Sánchez, JL, Melnik, D, Sandt, V, Kahlert, S, Marchal, S, Johnson, IR, Calvaruso, M, Liemersdorf, C, Wuest, SL, Grimm, D & Krüger, M 2023, 'Fluid and bubble flow detach adherent cancer cells to form spheroids on a random positioning machine', Cells, vol. 12, no. 22, article no. 2665. Open access 8 6
2023	Lazniewska, J, Li, KL, Johnson, IR, Sorvina, A, Logan, JM, Martini, C, Moore, C, Ung, BS, Karageorgos, L, Hickey, SM, Prabhakaran, S, Heatlie, JK, Brooks, RD, Huzzell, C, Warnock, N I, Moretti, P, Pitson, SM & Brooks, DA and 10 other authors 2023, 'Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression', Scientific Reports, vol. 13, no. 1, article no. 13489, pp. 1-18. Open access 11 10
2022	Johnson, IR, Rudebeck, EE, Sweetman, MJ, Sorvina, A, Ashton, TD, Pfeffer, FM, Brooks, DA & Hickey, SM 2022, 'A 3,4-dimethoxy-1,8-naphthalimide for lipid droplet imaging in live and fixed cells', Sensors and Actuators B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, vol. 365, article no. 131921, pp. 1-7. Open access 10 7 1
2020	Johnson, IR, Nguyen, CT, Wise, P & Grimm, D 2020, 'Implications of altered endosome and lysosome biology in space environments', International Journal of Molecular Sciences, vol. 21, article no. 8205, pp. 1-19. Open access 8 8

Journal Articles

Year	Output
2025	Heatlie, JK, Lazniewska, J, Moore, CR, Johnson, IR, Nturubika, BD, Williams, R, Ward, MP, O'Leary, JJ, Butler, LM & Brooks, DA 2025, 'Extracellular vesicles and tunnelling nanotubes as mediators of Prostate Cancer intercellular communication', Biomolecules, vol. 15, no. 1, article no. 23, pp. 1-22. Open access 1 1
2024	Logan, JM, Martini, C, Sorvina, A, Johnson, IR, Brooks, RD, Caruso, MC, Huzzell, C, Moore, CR, Karageorgos, L, Butler, LM, Tewari, P, Prabhakaran, S, Hickey, SM, Klebe, S, Samaratunga, H, Delahunt, B, Moretti, K, O'Leary, JJ, Brooks, DA & Ung, BS 2024, 'Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers', Scientific Data, vol. 11, article no. 852, pp. 1-10. Open access 1
2024	Martini, C, Logan, JM, Sorvina, A, Prabhakaran, S, Ung, BS, Johnson, IR, Hickey, SM, Brooks, RD, Caruso, MC, Klebe, S, Karageorgos, L, O'Leary, JJ, Delahunt, B, Samaratunga, H & Brooks, DA 2024, 'Distinct patterns of biomarker expression for atypical intraductal proliferations in prostate cancer', Virchows Archiv, vol. 485, pp. 723-728. Open access 1 2
2024	Nturubika, BD, Guardia, CM, Gershlick, DC, Logan, JM, Martino, C, Heatlie, JK, Lazniewska, J, Moore, C, Lam, GT, Li, KL, Ung, BS-Y, Brooks, RD, Hickey, SM, Bert, AG, Gregory, PA, Butler, LM, O'Leary, JJ, Brooks, DA & Johnson, IRD 2024, 'Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression', British Journal of Cancer, vol. 131, no. 8, pp. 1263-1278. Open access 2 2
2024	Nturubika, BD-D, Logan, J, Johnson, IRD, Moore, C, Li, KL, Tang, J, Lam, G, Parkinson-Lawrence, E, Williams, DB, Chakiris, J, Hindes, M, Brooks, RD, Gregory, P, Waugh, DJJ & Brooks, DA and 7other authors 2024, 'Components of the endosome-lysosome vesicular machinery as drivers of the metastatic cascade in prostate cancer', Cancers, vol. 17, no. 1, article no. 43, pp. 1-31. Open access 1
2024	Tang, J, Lam, GT, Brooks, RD, Miles, M, Useckaite, Z, Johnson, IR, Ung, BS, Martini, C, Karageorgos, L, Hickey, SM, Selemidis, S, Hopkins, AM, Rowland, A, Vather, R, O'Leary, JJ, Brooks, D., Caruso, MC & Logan, JM 2024, 'Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: a spotlight on the contribution of the endosome-lysosome system', Cancer Letters, vol. 585, article no. 216639, pp. 1-9. Open access 6 5
2023	Cortés-Sánchez, JL, Melnik, D, Sandt, V, Kahlert, S, Marchal, S, Johnson, IR, Calvaruso, M, Liemersdorf, C, Wuest, SL, Grimm, D & Krüger, M 2023, 'Fluid and bubble flow detach adherent cancer cells to form spheroids on a random positioning machine', Cells, vol. 12, no. 22, article no. 2665. Open access 8 6
2023	Hickey, SM, Johnson, IR, Dallerba, E, Hackett, MJ, Massi, M, Lazniewska, J, Thurgood, LA, Pfeffer, FM, Brooks, DA & Ashton, TD 2023, 'A fluorescent and solvatochromic 1,8-naphthalimide probe for detection of lipid droplet trafficking and biogenesis', Dyes and Pigments, vol. 217, article no. 111382, pp. 1-6. 8 8
2023	Lam, GT, Martini, C, Brooks, T, Prabhakaran, S, Hopkins, AM, Ung, BS-Y, Tang, J, Caruso, MC, Brooks, RD, Johnson, IR, Sorvina, A, Hickey, SM, Karageorgos, L, Klebe, S, O'Leary, JJ, Brooks, DA & Logan, JM 2023, 'Insights into melanoma clinical practice: a perspective for future research', Cancers, vol. 15, no. 18, pp. 1-9. Open access 3 3
2023	Lam, GT, Sorvina, A, Martini, C, Prabhakaran, S, Ung, BS, Lazniewska, J, Moore, CR, Beck, AR, Johnson, IR, Caruso, MC, Hickey, SM, Brooks, RD, Karageorgos, L, Brooks, DA & Logan, JM and 6 other authors 2023, 'Altered endosomal-lysosomal biogenesis in melanoma', Neoplasia, vol. 43, article no. 100924, pp. 1-10. Open access 3 3 1
2023	Lazniewska, J, Li, KL, Johnson, IR, Sorvina, A, Logan, JM, Martini, C, Moore, C, Ung, BS, Karageorgos, L, Hickey, SM, Prabhakaran, S, Heatlie, JK, Brooks, RD, Huzzell, C, Warnock, N I, Moretti, P, Pitson, SM & Brooks, DA and 10 other authors 2023, 'Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression', Scientific Reports, vol. 13, no. 1, article no. 13489, pp. 1-18. Open access 11 10
2023	Logan, JM, Hopkins, AM, Martini, C, Sorvina, A, Huzzell, C, Johnson, IR, Hickey, SM, Ung, BS-Y, Lazniewska, J, Brooks, RD, Moore, CR, Caruso, MC, Karageorgos, L, Esterman, A, Moretti, K & Brooks, DA and 23 other authors 2023, 'Prediction of prostate cancer biochemical and clinical recurrence is improved by IHC-Assisted Grading using Appl1, Sortilin and Syndecan-1', Cancers, vol. 15, no. 12, pp. 1-12. Open access 9 8 122
2023	Martini, C, Logan, JM, Sorvina, A, Gordon, C, Beck, AR, Ung, BS, Caruso, MC, Moore, C, Johnson, IR, Li, KL, Karageorgos, L, Esterman, AJ, Huzzell, C, Brooks, RD, Lazniewska, J, Hickey, SM, Bader, CA, Parkinson-Lawrence, E, Prabhakaran, S, Moretti, KL & Brooks, DA and 28 other authors 2023, 'Aberrant protein expression of Appl1, Sortilin and Syndecan-1 during the biological progression of prostate cancer', Pathology, vol. 55, no. 1, pp. 40-51. Open access 16 16 81
2023	Sorvina, A, Martini, C, Prabhakaran, S, Logan, JM, Ung, BS-Y, Moore, C, Johnson, IR, Lazniewska, J, Tewari, P, Malone, V, Brooks, RD, Hickey, SM, Caruso, MC, Klebe, S, Karageorgos, L, O'Leary, JJ, Delahunt, B, Samaratunga, H & Brooks, DA 2023, 'Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread', Pathology, vol. 55, no. 6, pp. 792-799. Open access 8 8
2022	Hickey, SM, Ung, B, Bader, C, Brooks, R, Lazniewska, J, Johnson, IR, Sorvina, A, Logan, J, Martini, C, Moore, CR, Karageorgos, L, Sweetman, MJ & Brooks, DA 2022, 'Fluorescence microscopy-an outline of hardware, biological handling, and fluorophore considerations', Cells, vol. 11, no. 35, pp. 1-32. Open access 62 49 1
2022	Johnson, IR, Rudebeck, EE, Sweetman, MJ, Sorvina, A, Ashton, TD, Pfeffer, FM, Brooks, DA & Hickey, SM 2022, 'A 3,4-dimethoxy-1,8-naphthalimide for lipid droplet imaging in live and fixed cells', Sensors and Actuators B: Chemical: International Journal Devoted to Research and Development of Physical and Chemical Transducers, vol. 365, article no. 131921, pp. 1-7. Open access 10 7 1
2022	Lam, GT, Prabhakaran, S, Sorvina, A, Martini, C, Ung, BS, Karageorgos, L, Hickey, SM, Lazniewska, J, Johnson, IR, Williams, DB, Klebe, S, Malone, V, O'Leary, JJ, Jackett, L, Brooks, DA & Logan, JM 2022, 'Pitfalls in cutaneous melanoma diagnosis and the need for new reliable markers', Molecular Diagnosis and Therapy, vol. 27, no. 1, pp. 49-60. Open access 8 10 42
2020	Johnson, IR, Nguyen, CT, Wise, P & Grimm, D 2020, 'Implications of altered endosome and lysosome biology in space environments', International Journal of Molecular Sciences, vol. 21, article no. 8205, pp. 1-19. Open access 8 8
2019	Johnson, IR & Logan, JM 2019, ''Seeing is Believing': enhancing student engagement with dynamic protein-model visualization', Biochemistry and Molecular Biology Education, vol. 47, no. 3, pp. 247-248.
2019	Johnson, IR, Sorvina, A, Logan, JM, Moore, CR, Heatlie, JK, Parkinson-Lawrence, EJ, Selemidis, S, O'leary, JJ, Butler, LM & Brooks, DA 2019, 'A paradigm in immunochemistry, revealed by monoclonal antibodies to spatially distinct epitopes on syntenin-1', International Journal of Molecular Sciences, vol. 20, no. 23, pp. 1-16. Open access 5 5 1
2018	Armstrong, HK, Gillis, JL, Johnson, IR, Nassar, ZD, Moldovan, M, Levrier, C, Sadowski, MC, Chin, MY, Tomlinson Guns, ES, Tarulli, G, Lynn, DJ, Brooks, DA, Selth, LA, Centenera, MM & Butler, LM 2018, 'Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion', Scientific Reports, vol. 8, no. 1, article no. 2090, pp. 1-14. Open access 32 32 2
2018	Harrison, IP, Vinh, A, Johnson, IR, Luong, R, Drummond, GR, Sobey, CG, Tiganis, T, Williams, ED, O'Leary, JJ, Brooks, DA & Selemidis, S 2018, 'NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development', Oncotarget, vol. 9, no. 83, pp. 35378-35393. Open access 22 1
2018	Sorvina, A, Bader, CA, Caporale, C, Carter, EA, Johnson, IR, Parkinson-Lawrence, EJ, Simpson, P V, Wright, PJ, Stagni, S, Lay, PA, Massi, M, Brooks, DA & Plush, SE 2018, 'Lipid profiles of prostate cancer cells', Oncotarget, vol. 9, no. 85, pp. 35541-35552. Open access 38 5
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 32 28 9
2016	Zhang, W, Garg, S, Eldi, P, Zhou, FH-h, Johnson, IR, Brooks, DA, Lam, F, Rychkov, G, Hayball, JD & Albrecht, H 2016, 'Targeting prostate cancer cells with genetically engineered polypeptide-based micelles displaying gastrin-releasing peptide', International Journal of Pharmaceutics, vol. 513, pp.270-279. 27 25 4
2015	Bader, CA, Shandala, T, Ng, YS, Johnson, IR & Brooks, DA 2015, 'Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes', Biology Open, vol. 4, pp. 1345-1355. Open access 42 41 1
2015	Johnson, IR, Parkinson-Lawrence, EJ, Keegan, H, Spillane, CD, Barry-O'Crowley, J, Watson, WR, Selemidis, S, Butler, LM, O'Leary, JJ & Brooks, DA 2015, 'Endosomal gene expression: A new indicator for prostate cancer patient prognosis?', Oncotarget, vol. 6, no.35, pp.. Open access 36 34 10
2014	Johnson, IR, Parkinson-Lawrence, EJ, Butler, LM & Brooks, DA 2014, 'Prostate cell lines as models for biomarker discovery: performance of current markers and the search for new biomarkers', Prostate, vol. 74, no. 5, pp. 547-560. 20 19
2014	Johnson, IR, Parkinson-Lawrence, EJ, Shandala, T, Weigert, R, Butler, LM & Brooks, DA 2014, 'Altered endosome biogenesis in prostate cancer has biomarker potential', Molecular Cancer Research, vol. 12, no. 12, pp. 1851-1862. Open access 39 39

Research

Patents

Details	Registry	Status
Methods for detecting prostate cancer Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto	AU	Filed
Methods for detecting prostate cancer Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto	EP	Filed
Methods for detecting prostate cancer Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto	SG	Filed
Methods for detecting prostate cancer Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto	US	Filed
Methods for detecting prostate cancer Brooks, Doug; Parkinson-Lawrence, Emma; Johnson, Ian; Butler, Lisa; Weigert, Roberto	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Aarhus University	DENMARK
Austin Health	AUSTRALIA
Children's Hospital Los Angeles	UNITED STATES
Curtin University	AUSTRALIA
Deakin University	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
German Aerospace Center	GERMANY
La Trobe University	AUSTRALIA
Lucerne University of Applied Sciences and Arts	SWITZERLAND
Malaghan Institute of Medical Research	NEW ZEALAND
Monash University	AUSTRALIA
National Institute of Child Health and Human Development	UNITED STATES
National Institutes of Health	UNITED STATES
National Research Council of Italy	ITALY
NIDCR	UNITED STATES
Otto von Guericke University Magdeburg	GERMANY
Queensland University of Technology	AUSTRALIA
RMIT University	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
The Coombe Hospital	IRELAND
Trinity College Dublin	IRELAND
University College Dublin	IRELAND
University Hospital Magdeburg	GERMANY
University of Adelaide	AUSTRALIA
University of Bologna	ITALY
University of British Columbia	CANADA
University of Cambridge	UNITED KINGDOM
University of Dublin	IRELAND
University of Melbourne	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Award The Freemasons Foundation	2014

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
111081 - Introducing a new paradigm for specific targeting of ovarian cancer cells with engineered nanoparticles, using G protein-coupled receptors as molecular entry points	Current
Defining critical changes in lipid metabolism during prostate cancer progression	Current
The role of membrane trafficking in prostate cancer metastasis	Current
The roles of molecular machinery in androgen receptor trafficking and development of prostate cancer	Current
Development of monoclonal antibody targeted therapeutics for prostate cancer	Completed

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Dr Ian Johnson

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Award

Teaching & student supervision

Courses and programs

Research degree supervision

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