Dr Jack Darby

Research Fellow UniSA Clinical & Health Sciences

City West Campus (HB5-25)
tel +61 8 830 21030

email Jack.Darby@unisa.edu.au

Research Degree Supervisor

About me

Pregnancy and Developmental Research
Magnetic Resonance Imaging (MRI)
Intrauterine Growth Restriction
Cardiac Development

Jack Darby is an early career researcher within the Early Origins of Adult Health Research Group at the University of South Australia. Jack’s research focuses on understanding the molecular mechanisms by which sub optimal in utero conditions such as fetal hypoxaemia and hypoglycaemia influence cardiac development and program adult onset cardiovascular disease. More recently he has been focussed on combining clinically translatable MRI measures with molecular techniques to test the effectiveness of intervention strategies that may reverse or prevent these detrimental molecular, morphological and functional changes from occurring in the fetal heart.

Ultimately, Jack hopes to validate MRI techniques to measure fetal... Read more

UniSA Clinical & Health Sciences

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Research

Research focus

Medical Physiology
Medical and Health Sciences
Physiology
Biochemistry and Cell Biology
Biological Sciences

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2019	Berry, MJ, Darby, JR, O'Byrne, DM, Dyson, RM, Sixtus, R, Holman, SL, Abelentseva, A, Bowler, P, Stanbridge, K & Morrison, JL 2019, 'Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes', The Journal of Physiology, vol. 597, no. 16, pp. 4165-4173. Open access 1 1 2
2019	Darby, JR, Mohd Dollah, MH, Regnault, TR, Williams, MT & Morrison, JL 2019, 'Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-are we ready for the clinic?', Pharmacological Research, vol. 144, pp. 264-278. Open access 17 17 7
2019	Duan, AQ, Darby, JR, Soo, JY, Lock, MC, Zhu, MY, Flynn, L V, Perumal, SR, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2019, 'Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 317, no. 6, pp. R780-R792. Open access 20 20 1
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 27 27 9
2018	Darby, JR, McMillen, IC & Morrison, JL 2018, 'Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart', The Journal of Physiology, vol. 596, no. 12, pp. 2345-2358. Open access 19 17 3

Journal Articles

Year	Output
2022	Zhang, WQ, Sorvina, A, Morrison, JL, Darby, JR, Brooks, DA, Plush, SE & Afshar Vahid, S 2022, 'Development of an optical fiber-based redox monitoring system for tissue metabolism', Journal of Biophotonics, vol. 15, no. 4, article no. e202100304, pp. 1-11. Open access
2021	Aujla, T, Darby, JR, Saini, BS, Lock, MC, Holman, SL, Bradshaw, EL, Perumal, SR, McInnes, SJ, Voelcker, NH, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep', Experimental Physiology, vol. 106, no. 5, pp. 1166-1180. 1 2 10
2021	Charest-Pekeski, AJ, Sheta, A, Taniguchi, L, McVey, MJ, Aujla, T, Cho, SK, Quinn, M, Holman, SL, Darby, JR, Morrison, JL & Haller, C and 12 other authors 2021, 'Achieving sustained extrauterine life: challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus', Physiological Reports, vol. 9, no. 5, article number e14742, pp. 1-20. Open access 1 8
2021	Darby, JR, Berry, MJ, Quinn, M, Holman, SL, Bradshaw, EL, Jesse, SM, Haller, C, Seed, M & Morrison, JL 2021, 'Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator', The Journal of Physiology, vol. 599, no. 10, pp. 2751-2761. Open access 6
2021	Darby, JR, Chiu, J, Regnault, TR & Morrison, JL 2021, 'Placental insufficiency induces a sexually dimorphic response in the expression of cardiac growth and metabolic signalling molecules upon exposure to a postnatal western diet in guinea pigs', Journal of Developmental Origins of Health and Disease, online, pp. 1-13. 5
2021	Dimasi, CG, Lazniewska, J, Plush, SE, Saini, BS, Holman, SL, Cho, SK, Wiese, MD, Sorvina, A, Macgowan, CK, Seed, M, Brooks, DA, Morrison, JL & Darby, JR 2021, 'Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output', Journal of Biophotonics, online, pp. 1-13. Open access 3 2 7
2021	Flouri, D, Darby, JR, Holman, SL, Perumal, SR, David, AL, Morrison, JL & Melbourne, A 2021, 'Magnetic resonance imaging of placentome development in the pregnant ewe', Placenta, vol. 105, pp. 61-69. Open access 1 1 10
2021	Lazniewska, J, Darby, JR, Holman, SL, Sorvina, A, Plush, SE, Massi, M, Brooks, DA & Morrison, JL 2021, 'In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat', Journal of Biophotonics, vol. 14, no. 4, article no. e202000322, pp. 1-13. 3 2 1
2021	McBride, GM, Meakin, AS, Soo, JY, Darby, JR, Varcoe, TJ, Bradshaw, EL, Lock, MC, Holman, SL, Saini, BS, Macgowan, CK, Seed, M, Berry, MJ, Wiese, MD & Morrison, JL 2021, 'Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit', Life Sciences, vol. 285, article no. 120016, pp. 1-9. 2 1 8
2021	Meakin, AS, Cuffe, JS, Darby, JR, Morrison, JL & Clifton, VL 2021, 'Let's talk about placental sex, baby: understanding mechanisms that drive female-and male-specific fetal growth and developmental outcomes', International Journal of Molecular Sciences, vol. 22, no. 12, article no. 6386, pp. 1-17. Open access 6 6 27
2021	Morrison, JL, Darby, JR & Michael, N 2021, 'Themed issue on the DOHaD workshop on retal, placental and pediatric imaging', Journal of Developmental Origins of Health and Disease, vol. 12, no. 2, pp. 151-152. Open access 8
2021	Ren, J, Darby, JR, Lock, MC, Holman, SL, Saini, BS, Bradshaw, EL, Orgeig, S, Perumal, SR, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus', The Journal of Physiology, vol. 599, no. 20, pp. 4705-4724. 1 10
2021	Ren, J, Lock, MC, Darby, JR, Orgeig, S, Holman, SL, Quinn, M, Seed, M, Muhlhausler, BS, Mcmillen, IC & Morrison, JL 2021, 'PPARγactivation in late gestation does not promote surfactant maturation in the fetal sheep lung', Journal of Developmental Origins of Health and Disease, in press, pp. 1-12. 1 2
2021	Saini, BS, Darby, JR, Marini, D, Portnoy, S, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Wald, RM, Windrim, R, MacGowan, CK, Kingdom, JC, Morrison, JL & Seed, M 2021, 'An MRI approach to assess placental function in healthy humans and sheep', The Journal of Physiology, vol. 599, no. 10, pp. 2573-2602. Open access 3 3 13
2021	Schrauben, EM, Darby, JR, Berry, MJ, Saini, BS, Quinn, M, Holman, SL, Bradshaw, EL, Lock, MC, Perumal, SR, Cho, SK, Aujla, T, Seed, M, Macgowan, CK & Morrison, JL 2021, 'Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets', Physiological Reports, vol. 9, no. 17, article no. e14999, pp. 1-15. Open access 9
2021	Wiese, MD, Berry, MJ, Hissaria, P, Darby, JR & Morrison, JL 2021, 'COVID-19: Can we treat the mother without harming her baby?', Journal of Developmental Origins of Health and Disease, online, pp. 1-11. Open access 2 14
2021	Wiese, MD, Meakin, AS, Varcoe, TJ, Darby, JR, Sarr, O, Kiser, P, Bradshaw, EL, Regnault, TR & Morrison, JL 2021, 'Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight', Life Sciences, vol. 287, article no. 120133, pp. 1-11. 2 1 3
2020	Cho, SK, Darby, JT, Saini, BS, Lock, MC, Holman, SL, Lim, JM, Seed, M, Perumal, SR, MacGowan, CK & Morrison, JL 2020, 'Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep', The Journal of Physiology, vol. 598, no. 13, pp. 2557-2573. Open access 7 7 7
2020	Darby, JR, Schrauben, EM, Saini, BS, Holman, SL, Rajan Perumal, S, Seed, M, MacGowan, CK & Morrison, JL 2020, 'Umbilical vein infusion of Prostaglandin I2 increases ductus venosus shunting of oxygen rich blood but does not increase cerebral oxygen delivery in the fetal sheep', The Journal of Physiology, vol. 598, no. 21, pp. 4957-4967. Open access 1 1 10
2020	Darby, JR, Varcoe, TJ, Holman, SL, McMillen, IC & Morrison, JL 2020, 'The reliance on α-adrenergic receptor stimuli for blood pressure regulation in the chronically hypoxaemic fetus is not dependent on post-ganglionic activation', The Journal of Physiology, vol. 599, no. 4, pp. 1307-1318. 4 4 9
2020	Darby, JR, Varcoe, TJ, Orgeig, S & Morrison, JL 2020, 'Cardiorespiratory consequences of intrauterine growth restriction: influence of timing, severity and duration of hypoxaemia', Theriogenology, vol. 150, pp. 84-95. 28 25 6
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Brooks, DA, Seed, M, Selvanayagam, JB & Morrison, JL 2020, 'Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts', Frontiers in Physiology, vol. 11, article no. 614, pp. 1-21. Open access 2 2 4
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Doug, AB, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M & Morrison, JL 2020, 'Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart', Physiological Genomics, vol. 52, no. 3, pp. 143-159. Open access 1 1 3
2020	McBride, GM, Wiese, MD, Soo, JY, Darby, JR, Berry, MJ, Varcoe, TJ & Morrison, JL 2020, 'The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity', Placenta, vol. 99, pp. 50-62. 1 79
2020	Morrison, JL, Ayonrinde, OT, Care, AS, Clarke, GD, Darby, JR, David, AL, Dean, JM, Hooper, SB, Kitchen, MJ, Macgowan, CK, Melbourne, A, McGillick, E V, McKenzie, CA, Michael, N, Mohammed, N, Sadananthan, SA, Schrauben, E, Regnault, TR & Velan, SS 2020, 'Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress', Journal of Developmental Origins of Health and Disease, online. 3 2 6
2020	Padhee, M, McMillen, IC, Zhang, S, MacLaughlin, SM, Armitage, JA, Head, GA, Darby, J, Kelly, JM, Rudiger, SR, Kleemann, DO, Walker, SK & Morrison, JL 2020, 'Impact of in vitro embryo culture and transfer on blood pressure regulation in the adolescent lamb', Journal of Developmental Origins of Health and Disease, vol. 45, pp. 138-141. 5
2020	Saini, BS, Darby, JR, Portnoy, S, Sun, L, van Amerom, J, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Kingdom, JC, Sled, JG, MacGowan, CK, Morrison, JL & Seed, M 2020, 'Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging', The Journal of Physiology, vol. 598, no. 15, pp. 3259-3281. Open access 18 17 12
2020	Schrauben, EM, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Seed, M, Morrison, JL & Macgowan, CK 2020, 'Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI', The Journal of Physiology, vol. 598, no. 17, pp. 3555-3567. 3 3 6
2020	Varcoe, TJ, Darby, JR, Holman, SL, Bradshaw, EL, Kuchel, T, Vaughan, L, Seed, M, Wiese, MD & Morrison, JL 2020, 'Fetal cardiovascular response to acute hypoxia during maternal anesthesia', Physiological Reports, vol. 8, no. 3, article no. e14365, pp. 1-15. Open access 6 6 4
2019	Berry, MJ, Darby, JR, O'Byrne, DM, Dyson, RM, Sixtus, R, Holman, SL, Abelentseva, A, Bowler, P, Stanbridge, K & Morrison, JL 2019, 'Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes', The Journal of Physiology, vol. 597, no. 16, pp. 4165-4173. Open access 1 1 2
2019	Darby, JR, Mohd Dollah, MH, Regnault, TR, Williams, MT & Morrison, JL 2019, 'Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-are we ready for the clinic?', Pharmacological Research, vol. 144, pp. 264-278. Open access 17 17 7
2019	Darby, JR, Saini, BS, Soo, JY, Lock, MC, Holman, SL, Bradshaw, EL, McInnes, SJ, Voelcker, NH, Macgowan, CK, Seed, M, Wiese, MD & Morrison, JL 2019, 'Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth', The Journal of Physiology, vol. 597, no. 20, pp. 5063-5077. Open access 12 12 9
2019	Darby, JR, Sorvina, A, Bader, CA, Lock, MC, Soo, JY, Holman, SL, Seed, M, Kuchel, T, Brooks, DA, Plush, SE & Morrison, JL 2019, 'Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissue', Journal of Biophotonics, online, pp. 1-13. Open access 7 8 3
2019	Duan, AQ, Darby, JR, Soo, JY, Lock, MC, Zhu, MY, Flynn, L V, Perumal, SR, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2019, 'Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 317, no. 6, pp. R780-R792. Open access 20 20 1
2019	Lock, MC, Darby, JR, Soo, JY, Brooks, DA, Perumal, SR, Selvanayagam, JB, Seed, M, MacGowan, CK, Porrello, ER, Tellam, RL & Morrison, JL 2019, 'Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period', Frontiers in Physiology, vol. 10, article no. 208, pp. 1-24. Open access 6 8 4
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 27 27 9
2019	Varcoe, TJ, Darby, JR, Gatford, KL, Holman, SL, Cheung, P, Berry, MJ, Wiese, MD & Morrison, JL 2019, 'Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery', Animal Frontiers, vol. 9, no. 3, pp. 60-67. Open access 21 18 3
2018	Darby, JR, McMillen, IC & Morrison, JL 2018, 'Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart', The Journal of Physiology, vol. 596, no. 12, pp. 2345-2358. Open access 19 17 3
2018	Morrison, J, Botting, KJ, Darby, J, David, AL, Dyson, RM, Gatford, KL, Gray, C, Herrera, EA, Hirst, JJ, Kim, B, Kind, KL, Krause, BJ, Matthews, SG, Palliser, HK, Regnault, TR, Richardson, BS, Sasaki, A, Thompson, LP & Berry, MJ 2018, 'Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic', The Journal of Physiology, vol. 596, no. 23, pp. 5535-5569. Open access 55 56 5
2018	Morrison, JL, Berry, MJ, Botting, KJ, Darby, JR, Frasch, MG, Gatford, KL, Giussani, DA, Gray, CL, Harding, R, Herrera, EA, Kemp, MW, Lock, MC, McMillen, IC, Moss, TJ, Musk, GC, Oliver, MH, Regnault, TR, Roberts, CT, Soo, JY & Tellam, RL 2018, 'Improving pregnancy outcomes in humans through studies in sheep', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 315, no. 6, pp. 1123-1153. Open access 67 66 1
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of Biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. Open access 5 6 4
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 17 14 8
2017	Duan, AQ, Lock, MC, Perumal, SR, Darby, JR, Soo, JY, Selvanayagam, JB, Macgowan, CK, Seed, M & Morrison, JL 2017, 'Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging', Journal of Cardiovascular Magnetic Resonance, vol. 19, no. 1, article no. 69, pp. 1-11. Open access 19 17 6
2015	Darby, J, Zhang, S, McMillen, I, Mühlhausler, B & Morrison, J 2015, 'Late gestation over nutrition alters the cardiac metabolic profile', Heart Lung and Circulation, vol. 24, no. S3, pp. S189-S189. Open access

Conferences

Year	Output
2017	Zhang, WQ, Morrison, JL, Darby, JR, Plush, S, Sorvina, A, Brooks, D, Monro, TM & Afshar Vahid, S 2017, 'A fibre optic fluorescence sensor to measure redox level in tissues', Nanophotonics Australasia 2017, SPIE, vol. 10456, article no. 104564R, pp. 1-6.

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Agency for Science, Technology and Research (A*STAR)	SINGAPORE
Baker Heart and Diabetes Institute	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Deakin University	AUSTRALIA
Fiona Stanley Hospital	AUSTRALIA
Flinders University	AUSTRALIA
Hudson Institute of Medical Research	AUSTRALIA
King's College London	UNITED KINGDOM
Monash University	AUSTRALIA
New Zealand Defence Force	NEW ZEALAND
Pontifical Catholic University of Chile	CHILE
Royal Children's Hospital	UNITED KINGDOM
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
South Australian Research and Development Institute (SARDI)	AUSTRALIA
The Hospital for Sick Children	CANADA
Univeristy of Toronto	CANADA
University College London	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Bologna	ITALY
University of Cambridge	UNITED KINGDOM
University of Chile	CHILE
University of Florida	UNITED STATES
University of Maryland	UNITED STATES
University of Melbourne	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Ontario	CANADA
University of Otago	NEW ZEALAND
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Texas Health Science Center at San Antonio	UNITED STATES
University of Toronto	CANADA
University of Washington, Seattle	UNITED STATES
University of Western Australia	AUSTRALIA
University of Western Ontario	CANADA
Western University	CANADA
Women and Children's Health Research Institute	CANADA

External engagement & recognition

Engagement/recognition	Year
Early Career Researcher Postdoctoral Publication - Best Paper Award Australian Physiological Society	2020
Member Fetal and Neonatal Physiological Society	2018
Member Perinatal Society of Australia and New Zealand (PSANZ)	2018
Member Australian Physiological Society	2018
Member Australian Society for Medical Research (ASMR)	2018
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2017
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2017
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2016
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2016

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Detecting biomarkers of fetal cardiac damage	Current
Using MRI to understand brain development in the fetus	Current
Why are small babies at risk of hypertension in adulthood? The role of oxygen and glucose in utero on blood pressure regulation	Current

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Dr Jack Darby

About me

About me

UniSA Clinical & Health Sciences

Other UniSA associations

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

Conferences

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Early Career Researcher Postdoctoral Publication - Best Paper Award

Member

Member

Member

Member

Local Organizing Committee Member-

State Committee Member, Sponsorship

Local Organizing Committee Member-

State Committee Member, Sponsorship

Teaching & student supervision

Courses and programs

Research degree supervision

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