Dr Jack Darby

Postdoctoral Research Fellow UniSA Clinical & Health Sciences

City West Campus (HB5-25)
tel +61 8 830 21030

email Jack.Darby@unisa.edu.au

Research Degree Supervisor

About me

Pregnancy and Developmental Research
Magnetic Resonance Imaging (MRI)
Intrauterine Growth Restriction
Cardiac Development

Jack Darby is an early career researcher within the Early Origins of Adult Health Research Group at the University of South Australia. Jack’s research focuses on understanding the molecular mechanisms by which sub optimal in utero conditions such as fetal hypoxaemia and hypoglycaemia influence cardiac development and program adult onset cardiovascular disease. More recently he has been focussed on combining clinically translatable MRI measures with molecular techniques to test the effectiveness of intervention strategies that may reverse or prevent these detrimental molecular, morphological and functional changes from occurring in the fetal heart.

Ultimately, Jack hopes to validate MRI techniques to measure fetal... Read more

UniSA Clinical & Health Sciences

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Research

Research focus

Medical Physiology
Medical and Health Sciences
Biological Sciences
Physiology
Biochemistry and Cell Biology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2022	Flouri, D, Darby, JR, Holman, SL, Cho, SK, Dimasi, CG, Perumal, SR, Ourselin, S, Aughwane, R, Mufti, N, Macgowan, CK, Seed, M, David, AL, Melbourne, A & Morrison, JL 2022, 'Placental MRI predicts fetal oxygenation and growth rates in sheep and human pregnancy', Advanced Science, vol. 9, no. 30, article no. 2203738, pp. 1-14. Open access 13 12 8
2022	Morrison, JL, Williams, GK, Cho, SK, Saini, BS, Meakin, AS, Holman, SL, Quinn, M, Wiese, MD, Macgowan, CK, Seed, M & Darby, JR 2022, 'MRI Characterization of blood flow and oxygen delivery in the fetal sheep whilst exposed to sildenafil citrate', Neonatology: Foetal and Neonatal Research, vol. 119, no. 6, pp. 735-744. Open access 7 7 8
2021	Darby, JR, Berry, MJ, Quinn, M, Holman, SL, Bradshaw, EL, Jesse, SM, Haller, C, Seed, M & Morrison, JL 2021, 'Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator', The Journal of Physiology, vol. 599, no. 10, pp. 2751-2761. Open access 6 6 6
2021	Dimasi, CG, Lazniewska, J, Plush, SE, Saini, BS, Holman, SL, Cho, SK, Wiese, MD, Sorvina, A, Macgowan, CK, Seed, M, Brooks, DA, Morrison, JL & Darby, JR 2021, 'Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output', Journal of Biophotonics, vol. 14, no. 12, article no. e202100157, pp. 1-13. Open access 13 13 6
2020	Darby, JR, Varcoe, TJ, Orgeig, S & Morrison, JL 2020, 'Cardiorespiratory consequences of intrauterine growth restriction: influence of timing, severity and duration of hypoxaemia', Theriogenology, vol. 150, pp. 84-95. Open access 50 44 6

Journal Articles

Year	Output
2024	Bertossa, MR, Darby, JR, Holman, SL, Meakin, AS, Li, C, Huber, HF, Wiese, MD, Nathanielsz, PW & Morrison, JL 2024, 'Maternal high fat-high energy diet alters metabolic factors in the non-human primate fetal heart', The Journal of Physiology, vol. 602, no. 17, pp. 4251-4269. Open access 162
2024	Cho, SK, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Williams, GK, Macgowan, CK, Seed, M & Morrison, JL 2024, 'Late-gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state', The Journal of Physiology, vol. 602, no. 24, pp. 7065-7083.
2024	Cho, SK, Darby, JR, Williams, GK, Holman, SL, Rai, A, Van Amerom, JF, Fan, CP, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2024, 'Post-myocardial infarction remodeling and hyperkinetic remote myocardium in sheep measured by cardiac MRI feature tracking', Journal of Magnetic Resonance Imaging, online, pp. 1-13. Open access 1 1
2024	Darby, JR, Saini, BS, Holman, SL, Hammond, SJ, Perumal, SR, Macgowan, CK, Seed, M & Morrison, JL 2024, 'Acute-on-chronic: using magnetic resonance imaging to disentangle the haemodynamic responses to acute and chronic fetal hypoxaemia', Frontiers in Medicine, vol. 11, pp. 1-14. Open access 4
2024	Dimasi, CG, Darby, JR, Holman, SL, Quinn, M, Meakin, AS, Seed, M, Wiese, MD & Morrison, JL 2024, 'Cardiac growth patterns and metabolism before and after birth in swine: role of miR in proliferation, hypertrophy and metabolism', Journal of Molecular and Cellular Cardiology Plus, vol. 9, article no. 100084, pp. 1-14. Open access
2024	Holmes, H, Saini, BS, Moir, OJ, Darby, JR, Morrison, JL, Sun, L & Seed, M 2024, 'Pulmonary vascular regulation in the fetal and transitional lung', Clinics in Perinatology, vol. 51, no. 1, pp. 1-19. Open access 1 1
2024	Kühle, H, Cho, SKS, Charest-Pekeski, AJ, Chow, JSM, Lee, FT, Aujla, T, Saini, BS, Lim, JM, Darby, JRT, Mroczek, D, Floh, AA, McVey, MJ, Morrison, JL, Seed, M, Sun, L & Haller, C 2024, 'Echocardiographic assessment of cardiovascular physiology of preterm miniature piglets supported with a pumped artificial placenta system', Prenatal Diagnosis, vol. 44, no. 6-7, pp. 888-898. Open access 4
2024	Robinson, JL, Roff, AJ, Hammond, SJ, Darby, JR, Meakin, AS, Holman, SL, Tai, A, Moss, TJ, Dimasi, CG, Jesse, SM, Wiese, MD, Davies, AN, Muhlhausler, BS, Bischof, RJ, Wallace, MJ, Clifton, VL, Morrison, JL, Stark, MJ & Gatford, KL 2024, 'Betamethasone improved near-term neonatal lamb lung maturation in experimental maternal asthma', Experimental Physiology, vol. 109, no. 11, pp. 1967-1979. Open access
2023	Darby, JR, Williams, GK, Cho, SK, Meakin, AS, Holman, SL, Quinn, M, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2023, 'Acute resveratrol exposure does not impact hemodynamics of the fetal sheep', Physiological Reports, vol. 11, no. 12, pp. 1-12. Open access 2 2 8
2023	Darby, JR, Zhang, S, Holman, SL, Muhlhausler, BS, McMillen, IC & Morrison, JL 2023, 'Cardiac growth and metabolism of the fetal sheep are not vulnerable to a 10 day increase in fetal glucose and insulin concentrations during late gestation', Heliyon, vol. 9, no. 7, article no. e18292. Open access 2 2
2023	Dimasi, CG, Darby, JR & Morrison, JL 2023, 'A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth', The Journal of Physiology, vol. 601, no. 8, pp. 1319-1341. Open access 15 13 9
2023	Dimasi, CG, Darby, JRT, Cho, SKS, Saini, BS, Holman, SL, Meakin, AS, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2023, 'Reduced in utero substrate supply decreases mitochondrial abundance and alters the expression of metabolic signalling molecules in the fetal sheep heart', The Journal of Physiology, volume 602, issue 21, pp. 5901-5922. Open access 5 5 2
2023	Kühle, H, Cho, SKS, Barber, N, Goolaub, DS, Darby, JRT, Morrison, JL, Haller, C, Sun, L & Seed, M 2023, 'Advanced imaging of fetal cardiac function', Frontiers in Cardiovascular Medicine, vol. 10, article no. 1206138, pp. 1-16. Open access 7 6 2
2023	Meakin, AS, Amirmostofian, M, Darby, JR, Holman, SL, Morrison, JL & Wiese, MD 2023, 'Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes', Placenta, vol. 131, no. , pp. 82-89. Open access 1 1 5
2023	Paramasivan, S, Morrison, JL, Lock, MC, Darby, JR, Barrero, RA, Mills, PC & Sadowski, P 2023, 'Automated proteomics workflows for high-throughput library generation and biomarker detection using data-independent acquisition', Journal of Proteome Research, vol. 22, no. 6, pp. 2018-2029. Open access 4 4
2023	Saini, BS, Ducas, R, Darby, JR, Marini, D, Sun, L, Macgowan, CK, Windrim, R, Kingdom, JC, Wald, RM, Morrison, JL & Seed, M 2023, 'Feasibility of MRI assessment of maternal-fetal oxygen transport and consumption relative to maternal position in healthy late gestational pregnancies', The Journal of Physiology, vol. 601, no. 23, pp. 5413-5436. Open access 3 3 2
2022	Charest-Pekeski, AJ, Cho, SK, Aujla, T, Sun, L, Quinn, M, Darby, JR, Morrison, JL & Haller, C and 13 other authors 2022, 'Impact of the addition of a centrifugal pump in a preterm miniature pig model of the artificial placenta', Frontiers in Physiology, vol. 13, article number 925772, pp. 1-17. Open access 9 7 23
2022	Darby, JR, Chiu, J, Regnault, TR & Morrison, JL 2022, 'Placental insufficiency induces a sexually dimorphic response in the expression of cardiac growth and metabolic signalling molecules upon exposure to a postnatal western diet in guinea pigs', Journal of Developmental Origins of Health and Disease, vol. 13, no. 3, pp. 345-357. Open access 4 4 5
2022	Dimasi, CG & Darby, JR 2022, 'Does the growth restricted fetal heart burn less fat?', The Journal of Physiology, vol. 600, no. 7, pp. 1585-1586. 4
2022	Flouri, D, Darby, JR, Holman, SL, Cho, SK, Dimasi, CG, Perumal, SR, Ourselin, S, Aughwane, R, Mufti, N, Macgowan, CK, Seed, M, David, AL, Melbourne, A & Morrison, JL 2022, 'Placental MRI predicts fetal oxygenation and growth rates in sheep and human pregnancy', Advanced Science, vol. 9, no. 30, article no. 2203738, pp. 1-14. Open access 13 12 8
2022	Hammond, SJ & Darby, JR 2022, 'A no brainer: intervening early to protect against perinatal brain injury', The Journal of Physiology, vol. 600, no. 18, pp. 4059-4061. 5
2022	Meakin, AS, Darby, JR, Holman, SL, Wiese, MD & Morrison, JL 2022, 'Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe', Life Sciences, vol. 298, article no. 120521, pp. 1-9. Open access 8 7 5
2022	Morrison, JL, Williams, GK, Cho, SK, Saini, BS, Meakin, AS, Holman, SL, Quinn, M, Wiese, MD, Macgowan, CK, Seed, M & Darby, JR 2022, 'MRI Characterization of blood flow and oxygen delivery in the fetal sheep whilst exposed to sildenafil citrate', Neonatology: Foetal and Neonatal Research, vol. 119, no. 6, pp. 735-744. Open access 7 7 8
2022	Ren, J, Lock, MC, Darby, JR, Orgeig, S, Holman, SL, Quinn, M, Seed, M, Muhlhausler, BS, Mcmillen, IC & Morrison, JL 2022, 'PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung', Journal of Developmental Origins of Health and Disease, vol. 12, no. 6, pp. 963-974. Open access 4 10 2
2022	Robinson, JL & Darby, JR 2022, 'Something worth waiting for: is delayed cord clamping always beneficial?', The Journal of Physiology, vol. 600, no. 16, pp. 3641-3642. 5
2022	Wiese, MD, Berry, MJ, Hissaria, P, Darby, JR & Morrison, JL 2022, 'COVID-19: Can we treat the mother without harming her baby?', Journal of Developmental Origins of Health and Disease, vol. 13, pp. 9-19. Open access 5 4 12
2022	Zhang, WQ, Sorvina, A, Morrison, JL, Darby, JR, Brooks, DA, Plush, SE & Afshar Vahid, S 2022, 'Development of an optical fiber-based redox monitoring system for tissue metabolism', Journal of Biophotonics, vol. 15, no. 4, article no. e202100304, pp. 1-11. Open access 2 2 1
2021	Aujla, T, Darby, JR, Saini, BS, Lock, MC, Holman, SL, Bradshaw, EL, Perumal, SR, McInnes, SJ, Voelcker, NH, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep', Experimental Physiology, vol. 106, no. 5, pp. 1166-1180. Open access 7 7 11
2021	Charest-Pekeski, AJ, Sheta, A, Taniguchi, L, McVey, MJ, Aujla, T, Cho, SK, Quinn, M, Holman, SL, Darby, JR, Morrison, JL & Haller, C and 12 other authors 2021, 'Achieving sustained extrauterine life: challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus', Physiological Reports, vol. 9, no. 5, article number e14742. Open access 20 20 237
2021	Darby, JR, Berry, MJ, Quinn, M, Holman, SL, Bradshaw, EL, Jesse, SM, Haller, C, Seed, M & Morrison, JL 2021, 'Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator', The Journal of Physiology, vol. 599, no. 10, pp. 2751-2761. Open access 6 6 6
2021	Darby, JR, Varcoe, TJ, Holman, SL, McMillen, IC & Morrison, JL 2021, 'The reliance on α-adrenergic receptor stimuli for blood pressure regulation in the chronically hypoxaemic fetus is not dependent on post-ganglionic activation', The Journal of Physiology, vol. 599, no. 4, pp. 1307-1318. Open access 7 7 7
2021	Dimasi, CG, Lazniewska, J, Plush, SE, Saini, BS, Holman, SL, Cho, SK, Wiese, MD, Sorvina, A, Macgowan, CK, Seed, M, Brooks, DA, Morrison, JL & Darby, JR 2021, 'Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output', Journal of Biophotonics, vol. 14, no. 12, article no. e202100157, pp. 1-13. Open access 13 13 6
2021	Flouri, D, Darby, JR, Holman, SL, Perumal, SR, David, AL, Morrison, JL & Melbourne, A 2021, 'Magnetic resonance imaging of placentome development in the pregnant ewe', Placenta, vol. 105, pp. 61-69. Open access 12 12 10
2021	Lazniewska, J, Darby, JR, Holman, SL, Sorvina, A, Plush, SE, Massi, M, Brooks, DA & Morrison, JL 2021, 'In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat', Journal of Biophotonics, vol. 14, no. 4, article no. e202000322, pp. 1-13. Open access 4 3 1
2021	McBride, GM, Meakin, AS, Soo, JY, Darby, JR, Varcoe, TJ, Bradshaw, EL, Lock, MC, Holman, SL, Saini, BS, Macgowan, CK, Seed, M, Berry, MJ, Wiese, MD & Morrison, JL 2021, 'Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit', Life Sciences, vol. 285, article no. 120016, pp. 1-9. Open access 12 10 7
2021	Meakin, AS, Cuffe, JS, Darby, JR, Morrison, JL & Clifton, VL 2021, 'Let's talk about placental sex, baby: understanding mechanisms that drive female-and male-specific fetal growth and developmental outcomes', International Journal of Molecular Sciences, vol. 22, no. 12, article no. 6386, pp. 1-17. Open access 75 70 26
2021	Morrison, JL, Ayonrinde, OT, Care, AS, Clarke, GD, Darby, JR, David, AL, Dean, JM, Hooper, SB, Kitchen, MJ, Macgowan, CK, Melbourne, A, McGillick, E V, McKenzie, CA, Michael, N, Mohammed, N, Sadananthan, SA, Schrauben, E, Regnault, TR & Velan, SS 2021, 'Seeing the fetus from a DOHaD perspective: discussion paper from the advanced imaging techniques of DOHaD applications workshop held at the 2019 DOHaD World Congress', Journal of Developmental Origins of Health and Disease, vol. 12, no. 2, pp. 153-167. 5 5 6
2021	Morrison, JL, Darby, JR & Michael, N 2021, 'Themed issue on the DOHaD workshop on fetal, placental and pediatric imaging', Journal of Developmental Origins of Health and Disease, vol. 12, no. 2, pp. 151-152. Open access 8
2021	Padhee, M, McMillen, IC, Zhang, S, MacLaughlin, SM, Armitage, JA, Head, GA, Darby, J, Kelly, JM, Rudiger, SR, Kleemann, DO, Walker, SK & Morrison, JL 2021, 'Impact of in vitro embryo culture and transfer on blood pressure regulation in the adolescent lamb', Journal of Developmental Origins of Health and Disease, vol. 45, pp. 138-141. Open access 2 1 4
2021	Ren, J, Darby, JR, Lock, MC, Holman, SL, Saini, BS, Bradshaw, EL, Orgeig, S, Perumal, SR, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus', The Journal of Physiology, vol. 599, no. 20, pp. 4705-4724. Open access 9 6 10
2021	Saini, BS, Darby, JR, Marini, D, Portnoy, S, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Wald, RM, Windrim, R, MacGowan, CK, Kingdom, JC, Morrison, JL & Seed, M 2021, 'An MRI approach to assess placental function in healthy humans and sheep', The Journal of Physiology, vol. 599, no. 10, pp. 2573-2602. Open access 22 20 13
2021	Schrauben, EM, Darby, JR, Berry, MJ, Saini, BS, Quinn, M, Holman, SL, Bradshaw, EL, Lock, MC, Perumal, SR, Cho, SK, Aujla, T, Seed, M, Macgowan, CK & Morrison, JL 2021, 'Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets', Physiological Reports, vol. 9, no. 17, article no. e14999, pp. 1-15. Open access 4 4 8
2021	Wiese, MD, Meakin, AS, Varcoe, TJ, Darby, JR, Sarr, O, Kiser, P, Bradshaw, EL, Regnault, TR & Morrison, JL 2021, 'Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight', Life Sciences, vol. 287, article no. 120133, pp. 1-11. Open access 6 6 2
2020	Cho, SK, Darby, JT, Saini, BS, Lock, MC, Holman, SL, Lim, JM, Perumal, SR, Seed, M, MacGowan, CK & Morrison, JL 2020, 'Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep', The Journal of Physiology, vol. 598, no. 13, pp. 2557-2573. Open access 21 20 5
2020	Darby, JR, Schrauben, EM, Saini, BS, Holman, SL, Rajan Perumal, S, Seed, M, MacGowan, CK & Morrison, JL 2020, 'Umbilical vein infusion of Prostaglandin I2 increases ductus venosus shunting of oxygen rich blood but does not increase cerebral oxygen delivery in the fetal sheep', The Journal of Physiology, vol. 598, no. 21, pp. 4957-4967. Open access 13 12 9
2020	Darby, JR, Sorvina, A, Bader, CA, Lock, MC, Soo, JY, Holman, SL, Seed, M, Kuchel, T, Brooks, DA, Plush, SE & Morrison, JL 2020, 'Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissue', Journal of Biophotonics, 13, no. 3, article no. e201960085, pp. 1-13. Open access 12 12 3
2020	Darby, JR, Varcoe, TJ, Orgeig, S & Morrison, JL 2020, 'Cardiorespiratory consequences of intrauterine growth restriction: influence of timing, severity and duration of hypoxaemia', Theriogenology, vol. 150, pp. 84-95. Open access 50 44 6
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Brooks, DA, Seed, M, Selvanayagam, JB & Morrison, JL 2020, 'Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts', Frontiers in Physiology, vol. 11, article no. 614, pp. 1-21. Open access 8 7 4
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Doug, AB, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M & Morrison, JL 2020, 'Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart', Physiological Genomics, vol. 52, no. 3, pp. 143-159. Open access 5 4 3
2020	McBride, GM, Wiese, MD, Soo, JY, Darby, JR, Berry, MJ, Varcoe, TJ & Morrison, JL 2020, 'The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity', Placenta, vol. 99, pp. 50-62. 8 8 79
2020	Saini, BS, Darby, JR, Portnoy, S, Sun, L, van Amerom, J, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Kingdom, JC, Sled, JG, MacGowan, CK, Morrison, JL & Seed, M 2020, 'Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging', The Journal of Physiology, vol. 598, no. 15, pp. 3259-3281. Open access 50 47 10
2020	Schrauben, EM, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Seed, M, Morrison, JL & Macgowan, CK 2020, 'Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI', The Journal of Physiology, vol. 598, no. 17, pp. 3555-3567. Open access 9 9 6
2020	Varcoe, TJ, Darby, JR, Holman, SL, Bradshaw, EL, Kuchel, T, Vaughan, L, Seed, M, Wiese, MD & Morrison, JL 2020, 'Fetal cardiovascular response to acute hypoxia during maternal anesthesia', Physiological Reports, vol. 8, no. 3, article no. e14365, pp. 1-15. Open access 12 11 4
2019	Berry, MJ, Darby, JR, O'Byrne, DM, Dyson, RM, Sixtus, R, Holman, SL, Abelentseva, A, Bowler, P, Stanbridge, K & Morrison, JL 2019, 'Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes', The Journal of Physiology, vol. 597, no. 16, pp. 4165-4173. Open access 1 1 2
2019	Darby, JR, Mohd Dollah, MH, Regnault, TR, Williams, MT & Morrison, JL 2019, 'Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-are we ready for the clinic?', Pharmacological Research, vol. 144, pp. 264-278. Open access 33 31 6
2019	Darby, JR, Saini, BS, Soo, JY, Lock, MC, Holman, SL, Bradshaw, EL, McInnes, SJ, Voelcker, NH, Macgowan, CK, Seed, M, Wiese, MD & Morrison, JL 2019, 'Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth', The Journal of Physiology, vol. 597, no. 20, pp. 5063-5077. Open access 32 30 9
2019	Duan, AQ, Darby, JR, Soo, JY, Lock, MC, Zhu, MY, Flynn, L V, Perumal, SR, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2019, 'Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 317, no. 6, pp. R780-R792. Open access 32 33 1
2019	Lock, MC, Darby, JR, Soo, JY, Brooks, DA, Perumal, SR, Selvanayagam, JB, Seed, M, MacGowan, CK, Porrello, ER, Tellam, RL & Morrison, JL 2019, 'Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period', Frontiers in Physiology, vol. 10, article no. 208, pp. 1-24. Open access 20 20 4
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 46 48 9
2019	Varcoe, TJ, Darby, JR, Gatford, KL, Holman, SL, Cheung, P, Berry, MJ, Wiese, MD & Morrison, JL 2019, 'Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery', Animal Frontiers, vol. 9, no. 3, pp. 60-67. Open access 31 29 2
2018	Darby, JR, McMillen, IC & Morrison, JL 2018, 'Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart', The Journal of Physiology, vol. 596, no. 12, pp. 2345-2358. Open access 31 29 3
2018	Morrison, J, Botting, KJ, Darby, J, David, AL, Dyson, RM, Gatford, KL, Gray, C, Herrera, EA, Hirst, JJ, Kim, B, Kind, KL, Krause, BJ, Matthews, SG, Palliser, HK, Regnault, TR, Richardson, BS, Sasaki, A, Thompson, LP & Berry, MJ 2018, 'Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic', The Journal of Physiology, vol. 596, no. 23, pp. 5535-5569. Open access 97 98 5
2018	Morrison, JL, Berry, MJ, Botting, KJ, Darby, JR, Frasch, MG, Gatford, KL, Giussani, DA, Gray, CL, Harding, R, Herrera, EA, Kemp, MW, Lock, MC, McMillen, IC, Moss, TJ, Musk, GC, Oliver, MH, Regnault, TR, Roberts, CT, Soo, JY & Tellam, RL 2018, 'Improving pregnancy outcomes in humans through studies in sheep', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 315, no. 6, pp. 1123-1153. Open access 121 115 1
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of Biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. Open access 5 6 4
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 32 28 9
2017	Duan, AQ, Lock, MC, Perumal, SR, Darby, JR, Soo, JY, Selvanayagam, JB, Macgowan, CK, Seed, M & Morrison, JL 2017, 'Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging', Journal of Cardiovascular Magnetic Resonance, vol. 19, no. 1, article no. 69, pp. 1-11. Open access 33 30 6
2015	Darby, J, Zhang, S, McMillen, I, Mühlhausler, B & Morrison, J 2015, 'Late gestation over nutrition alters the cardiac metabolic profile', Heart Lung and Circulation, vol. 24, no. S3, pp. S189-S189. Open access

Conferences

Year	Output
2017	Zhang, WQ, Morrison, JL, Darby, JR, Plush, S, Sorvina, A, Brooks, D, Monro, TM & Afshar Vahid, S 2017, 'A fibre optic fluorescence sensor to measure redox level in tissues', Nanophotonics Australasia 2017, SPIE, vol. 10456, article no. 104564R, pp. 1-6.

External engagement & recognition

Collaborations

Highlights

2022: Chair, Local organising commitee for the 2022 annual meeting of the Australia and New Zealand Developmental Origins of Health and Disease Socety. https://web.cvent.com/event/36a9f39f-2d61-40b1-86f2-bd25ea809e9c/summary

2021- present: South Australian State Representative for the Australia and New Zealand Developmental Origins of Health and Disease Socety.

External engagement & recognition

Collaborations

Organisation	Country
Agency for Science, Technology and Research (A*STAR)	SINGAPORE
Baker Heart and Diabetes Institute	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Deakin University	AUSTRALIA
Federation University Australia	AUSTRALIA
Fiona Stanley Hospital	AUSTRALIA
Flinders University	AUSTRALIA
Hudson Institute of Medical Research	AUSTRALIA
King's College London	UNITED KINGDOM
Monash University	AUSTRALIA
New Zealand Defence Force	NEW ZEALAND
Pontifical Catholic University of Chile	CHILE
Queensland University of Technology	AUSTRALIA
Royal Children's Hospital	UNITED KINGDOM
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
South Australian Research and Development Institute (SARDI)	AUSTRALIA
Texas Biomedical Research Institute	UNITED STATES
The Aga Khan University Hospital	PAKISTAN
The Hospital for Sick Children	CANADA
Univeristy of Toronto	CANADA
University College London	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Bologna	ITALY
University of Cambridge	UNITED KINGDOM
University of Chile	CHILE
University of Florida	UNITED STATES
University of Manitoba	CANADA
University of Maryland	UNITED STATES
University of Melbourne	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Ontario	CANADA
University of Otago	NEW ZEALAND
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Texas Health Science Center at San Antonio	UNITED STATES
University of Toronto	CANADA
University of Washington, Seattle	UNITED STATES
University of Western Australia	AUSTRALIA
University of Wyoming	UNITED STATES
Western University	CANADA
Women and Children's Health Research Institute	CANADA

External engagement & recognition

Engagement/recognition	Year
Early Career Researcher Postdoctoral Publication - Best Paper Award Australian Physiological Society	2020
Member Perinatal Society of Australia and New Zealand (PSANZ)	2018
Member Australian Physiological Society	2018
Member Australian Society for Medical Research (ASMR)	2018
Member Fetal and Neonatal Physiological Society	2018
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2017
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2017
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2016
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2016

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Born too soon: Impact on ability to metabolise drugs	Current
Using MRI to understand brain development in the fetus	Current
Why are small babies at risk of hypertension in adulthood? The role of oxygen and glucose in utero on blood pressure regulation	Current
Molecular regulation of cardiomyocyte maturation	Completed

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Dr Jack Darby

About me

About me

UniSA Clinical & Health Sciences

Other UniSA associations

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

Conferences

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Early Career Researcher Postdoctoral Publication - Best Paper Award

Member

Member

Member

Member

Local Organizing Committee Member-

State Committee Member, Sponsorship

Local Organizing Committee Member-

State Committee Member, Sponsorship

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery