Dr Jack Darby

Research Assistant: Early Origins of Adult Health UniSA Clinical & Health Sciences

email Jack.Darby@unisa.edu.au

About me

Pregnancy and Developmental Research
Magnetic Resonance Imaging (MRI)
Intrauterine Growth Restriction
Cardiac Development

Jack Darby is an early career researcher within the Early Origins of Adult Health Research Group at the University of South Australia. Jack’s research focuses on understanding the molecular mechanisms by which sub optimal in utero conditions such as fetal hypoxaemia and hypoglycaemia influence cardiac development and program adult onset cardiovascular disease. More recently he has been focussed on combining clinically translatable MRI measures with molecular techniques to test the effectiveness of intervention strategies that may reverse or prevent these detrimental molecular, morphological and functional changes from occurring in the fetal heart.

Ultimately, Jack hopes to validate MRI techniques to measure fetal... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research themes

An age friendly world
Healthy futures

Research focus

Medical Physiology
Biological Sciences
Cardiovascular Medicine and Haematology
Medical and Health Sciences
Physiology

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2019	Berry, MJ, Darby, JR, O'Byrne, DM, Dyson, RM, Sixtus, R, Holman, SL, Abelentseva, A, Bowler, P, Stanbridge, K & Morrison, JL 2019, 'Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes', The Journal of Physiology, vol. 597, no. 16, pp. 4165-4173. Open access 1 2
2019	Darby, JR, Mohd Dollah, MH, Regnault, TR, Williams, MT & Morrison, JL 2019, 'Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-are we ready for the clinic?', Pharmacological Research, vol. 144, pp. 264-278. Open access 6 4 7
2019	Duan, AQ, Darby, JR, Soo, JY, Lock, MC, Zhu, MY, Flynn, L V, Perumal, SR, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2019, 'Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 317, no. 6, pp. R780-R792. Open access 11 5 1
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 13 5 8
2018	Darby, JR, McMillen, IC & Morrison, JL 2018, 'Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart', The Journal of Physiology, vol. 596, no. 12, pp. 2345-2358. Open access 7 7 3

Journal Articles

Year	Output
2020	Cho, SK, Darby, JT, Saini, BS, Lock, MC, Holman, SL, Lim, JM, Seed, M, Perumal, SR, MacGowan, CK & Morrison, JL 2020, 'Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep', The Journal of Physiology, vol. 598, no. 13, pp. 2557-2573.
2020	Darby, JR, Schrauben, EM, Saini, BS, Holman, SL, Rajan Perumal, S, Seed, M, MacGowan, CK & Morrison, JL 2020, 'Umbilical vein infusion of Prostaglandin I2 increases ductus venosus shunting of oxygen rich blood but does not increase cerebral oxygen delivery in the fetal sheep', The Journal of Physiology, online, pp. 1-26.
2020	Darby, JR, Varcoe, TJ, Orgeig, S & Morrison, JL 2020, 'Cardiorespiratory consequences of intrauterine growth restriction: influence of timing, severity and duration of hypoxaemia', Theriogenology, in press, pp. 1-12. 4 3
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Brooks, DA, Seed, M, Selvanayagam, JB & Morrison, JL 2020, 'Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts', Frontiers in Physiology, vol. 11, article no. 614, pp. 1-21. Open access
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Doug, AB, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M & Morrison, JL 2020, 'Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart', Physiological Genomics, vol. 52, no. 3, pp. 143-159. 1
2020	Saini, BS, Darby, JR, Portnoy, S, Sun, L, van Amerom, J, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Kingdom, JC, Sled, JG, MacGowan, CK, Morrison, JL & Seed, M 2020, 'Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging', The Journal of Physiology, online, pp. 1-62. 1
2020	Schrauben, EM, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Seed, M, Morrison, JL & Macgowan, CK 2020, 'Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI', The Journal of Physiology, online, pp. 1-13. 1
2020	Varcoe, TJ, Darby, JR, Holman, SL, Bradshaw, EL, Kuchel, T, Vaughan, L, Seed, M, Wiese, MD & Morrison, JL 2020, 'Fetal cardiovascular response to acute hypoxia during maternal anesthesia', Physiological Reports, vol. 8, no. 3, article no. e14365, pp. 1-15. Open access 1 5
2019	Berry, MJ, Darby, JR, O'Byrne, DM, Dyson, RM, Sixtus, R, Holman, SL, Abelentseva, A, Bowler, P, Stanbridge, K & Morrison, JL 2019, 'Arginine Vasopressin improves cerebral perfusion following controlled haemorrhage in adult ewes', The Journal of Physiology, vol. 597, no. 16, pp. 4165-4173. Open access 1 2
2019	Darby, JR, Mohd Dollah, MH, Regnault, TR, Williams, MT & Morrison, JL 2019, 'Systematic review: impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications-are we ready for the clinic?', Pharmacological Research, vol. 144, pp. 264-278. Open access 6 4 7
2019	Darby, JR, Saini, BS, Soo, JY, Lock, MC, Holman, SL, Bradshaw, EL, McInnes, SJ, Voelcker, NH, Macgowan, CK, Seed, M, Wiese, MD & Morrison, JL 2019, 'Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth', The Journal of Physiology, vol. 597, no. 20, pp. 5063-5077. 4 1 10
2019	Darby, JR, Sorvina, A, Bader, CA, Lock, MC, Soo, JY, Holman, SL, Seed, M, Kuchel, T, Brooks, DA, Plush, SE & Morrison, JL 2019, 'Detecting metabolic differences in fetal and adult sheep adipose and skeletal muscle tissue', Journal of Biophotonics, online, pp. 1-13. 1 3
2019	Duan, AQ, Darby, JR, Soo, JY, Lock, MC, Zhu, MY, Flynn, L V, Perumal, SR, Macgowan, CK, Selvanayagam, JB, Morrison, JL & Seed, M 2019, 'Feasibility of phase-contrast cine magnetic resonance imaging for measuring blood flow in the sheep fetus', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 317, no. 6, pp. R780-R792. Open access 11 5 1
2019	Lock, MC, Darby, JR, Soo, JY, Brooks, DA, Perumal, SR, Selvanayagam, JB, Seed, M, MacGowan, CK, Porrello, ER, Tellam, RL & Morrison, JL 2019, 'Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period', Frontiers in Physiology, vol. 10, article no. 208, pp. 1-24. Open access 4 2 4
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 13 5 8
2019	Varcoe, TJ, Darby, JR, Gatford, KL, Holman, SL, Cheung, P, Berry, MJ, Wiese, MD & Morrison, JL 2019, 'Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery', Animal Frontiers, vol. 9, no. 3, pp. 60-67. Open access 7 1 3
2018	Darby, JR, McMillen, IC & Morrison, JL 2018, 'Maternal undernutrition in late gestation increases IGF2 signalling molecules and collagen deposition in the right ventricle of the fetal sheep heart', The Journal of Physiology, vol. 596, no. 12, pp. 2345-2358. Open access 7 7 3
2018	Morrison, J, Botting, KJ, Darby, J, David, AL, Dyson, RM, Gatford, KL, Gray, C, Herrera, EA, Hirst, JJ, Kim, B, Kind, KL, Krause, BJ, Matthews, SG, Palliser, HK, Regnault, TR, Richardson, BS, Sasaki, A, Thompson, LP & Berry, MJ 2018, 'Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic', The Journal of Physiology, vol. 596, no. 23, pp. 5535-5569. Open access 25 19 6
2018	Morrison, JL, Berry, MJ, Botting, KJ, Darby, JR, Frasch, MG, Gatford, KL, Giussani, DA, Gray, CL, Harding, R, Herrera, EA, Kemp, MW, Lock, MC, McMillen, IC, Moss, TJ, Musk, GC, Oliver, MH, Regnault, TR, Roberts, CT, Soo, JY & Tellam, RL 2018, 'Improving pregnancy outcomes in humans through studies in sheep', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 315, no. 6, pp. 1123-1153. Open access 26 17 1
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of Biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. Open access 3 3 4
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 7 4 9
2017	Duan, AQ, Lock, MC, Perumal, SR, Darby, JR, Soo, JY, Selvanayagam, JB, Macgowan, CK, Seed, M & Morrison, JL 2017, 'Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging', Journal of Cardiovascular Magnetic Resonance, vol. 19, no. 1, article no. 69, pp. 1-11. Open access 16 11 6
2015	Darby, J, Zhang, S, McMillen, I, Mühlhausler, B & Morrison, J 2015, 'Late gestation over nutrition alters the cardiac metabolic profile', Heart Lung and Circulation, vol. 24, no. S3, pp. S189-S189.

Conferences

Year	Output
2017	Zhang, WQ, Morrison, JL, Darby, JR, Plush, S, Sorvina, A, Brooks, D, Monro, TM & Afshar Vahid, S 2017, 'A fibre optic fluorescence sensor to measure redox level in tissues', Nanophotonics Australasia 2017, SPIE, vol. 10456, article no. 104564R, pp. 1-6.

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Flinders University	AUSTRALIA
Monash University	AUSTRALIA
New Zealand Defence Force	NEW ZEALAND
Pontifical Catholic University of Chile	CHILE
Royal Children's Hospital	UNITED KINGDOM
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
The Hospital for Sick Children	UNITED STATES
Univeristy of Toronto	CANADA
University College London	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Bologna	ITALY
University of Cambridge	UNITED KINGDOM
University of Chile	CHILE
University of Florida	UNITED STATES
University of Maryland	UNITED STATES
University of Melbourne	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Ontario	CANADA
University of Otago	NEW ZEALAND
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Toronto	CANADA
University of Washington, Seattle	UNITED STATES
University of Western Australia	AUSTRALIA
Western University	CANADA
Women and Children's Health Research Institute	CANADA

External engagement & recognition

Engagement/recognition	Year
Member Fetal and Neonatal Physiological Society	2018
Member Perinatal Society of Australia and New Zealand (PSANZ)	2018
Member Australian Physiological Society	2018
Member Australian Society for Medical Research (ASMR)	2018
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2017
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2017
Local Organizing Committee Member- Australian Physiological Society Annual Meeting, Adelaide	2016
State Committee Member, Sponsorship Australian Society for Medical Research (ASMR)	2016

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Dr Jack Darby

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Projects

Outputs

Highlights

Journal Articles

Conferences

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Member

Member

Member

Member

Local Organizing Committee Member-

State Committee Member, Sponsorship

Local Organizing Committee Member-

State Committee Member, Sponsorship

Teaching & student supervision

Courses and programs

Courses I teach and/or co-ordinate

Gallery