Dr Jan Kazenwadel

Research Fellow Centre for Cancer Biology

City West Campus (HB10-25)
tel +61 8 830 27907

email Jan.Kazenwadel@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Medical and Health Sciences
Biological Sciences
Clinical Sciences
Cardiovascular Medicine and Haematology
Immunology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2023	Kazenwadel, J, Venugopal, P, Oszmiana, A, Toubia, J, Panara, V, Piltz, SG, Brown, C, Ma, W, Schreiber, AW, Koltowska, K, Taoudi, S, Thomas, PQ, Scott, HS & Harvey, NL 2023, 'A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature', Nature, vol. 614, no. 7947, pp 343-348. 24 21 162
2022	Byrne, AB, Brouillard, P, Sutton, DL, Kazenwadel, J, Montazaribarforoush, S, Secker, GA, Oszmiana, A, Babic, M, Betterman, KL, Brautigan, PJ, Hahn, CN, Arts, P, Scott, HS & Harvey, NL and 18 other authors 2022, 'Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema', Science Translational Medicine, vol. 14, no. 634, article no. eabm4869, pp. 1-14. 32 22 182
2015	Kazenwadel, J, Betterman, KL, Chong, C-E, Stokes, PH, Lee, YK, Secker, GA, Agalarov, Y, Demir, CS, Lawrence, DM, Sutton, DL, Tabruyn, SP, Miura, N, Salminen, M, Petrova, T, Matthew, JM, Hahn, CN, Scott, HS & Harvey, NL 2015, 'GATA2 is required for lymphatic vessel valve development and maintenance', Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994. Open access 186 167 18
2012	Kazenwadel, J, Secker, GA, Liu, YJ, Rosenfeld, JA, Chong, C-E, Scott, HS & Harvey, NL and 14 other authors 2012, 'Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature', Blood, vol. 119, no. 5, pp. 1283-1291. Open access 242 213
2010	Kazenwadel, J, Michael, MZ & Harvey, NL 2010, 'Prox1 expression is negatively regulated by miR-181 in endothelial cells', Blood, vol. 116, no. 13, pp. 2395-2401. Open access 139 137

Journal Articles

Year	Output
2024	Panara, V, Yu, H, Peng, D, Staxäng, K, Hodik, M, Filipek-Gorniok, B, Kazenwadel, J, Skoczylas, R, Mason, E, Allalou, A, Harvey, NL, Haitina, T, Hogan, BM & Koltowska, K 2024, 'Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds', Development, vol. 151, no. 9, pp. 1-14. Open access 3 3 6
2024	Williamson, AE, Liyanage, S, Hassanshahi, M, Dona, MS, Kazenwadel, J, Harvey, NL, Bonder, CS & Psaltis, PJ and 19 other authors 2024, 'Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta', Nature Communications, vol. 15, no. 1, pp. 1-21. Open access 4 3 198
2023	Chiang, IK, Graus, MS, Kirschnick, N, Davidson, T, Kazenwadel, J, Arriola-Martinez, L, Harvey, NL & Francois, M and 13 other authors 2023, 'The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner', The EMBO Journal, vol. 42, no. 5, article no. e109032. Open access 8 8 7
2023	Kazenwadel, J, Venugopal, P, Oszmiana, A, Toubia, J, Panara, V, Piltz, SG, Brown, C, Ma, W, Schreiber, AW, Koltowska, K, Taoudi, S, Thomas, PQ, Scott, HS & Harvey, NL 2023, 'A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature', Nature, vol. 614, no. 7947, pp 343-348. 24 21 162
2022	Byrne, AB, Brouillard, P, Sutton, DL, Kazenwadel, J, Montazaribarforoush, S, Secker, GA, Oszmiana, A, Babic, M, Betterman, KL, Brautigan, PJ, Hahn, CN, Arts, P, Scott, HS & Harvey, NL and 18 other authors 2022, 'Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema', Science Translational Medicine, vol. 14, no. 634, article no. eabm4869, pp. 1-14. 32 22 182
2020	Betterman, KL, Sutton, DL, Secker, GA, Kazenwadel, J, Oszmiana, A, Lim, L, Miura, N, Sorokin, L, Hogan, BM, Kahn, ML, McNeill, H & Harvey, NL 2020, 'Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow', Journal of Clinical Investigation, vol. 130, no. 6, pp. 3315-3328. Open access 49 42 19
2018	Frye, M, Taddei, A, Dierkes, C, Martinez-Corral, I, Fielden, M, Ortsater, H, Kazenwadel, J, Calado, DP, Ostergaard, P, Salminen, M, He, L, Harvey, NL, Kiefer, F & Makinen, T 2018, 'Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program', Nature Communications, vol. 9, no. 1, article no. 1511, pp. 1-16. Open access 125 119 30
2018	Kazenwadel, J & Harvey, NL 2018, 'Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis', Current Opinion in Immunology, vol. 53, pp. 81-87. 23 20 3
2016	Kazenwadel, J & Harvey, NL 2016, 'Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels', Developmental Dynamics, vol. 245, no. 3, pp. 209-219. Open access 30 29 4
2015	Kazenwadel, J, Betterman, KL, Chong, C-E, Stokes, PH, Lee, YK, Secker, GA, Agalarov, Y, Demir, CS, Lawrence, DM, Sutton, DL, Tabruyn, SP, Miura, N, Salminen, M, Petrova, T, Matthew, JM, Hahn, CN, Scott, HS & Harvey, NL 2015, 'GATA2 is required for lymphatic vessel valve development and maintenance', Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994. Open access 186 167 18
2014	Bowles, J, Secker, GA, Nguyen, C, Kazenwadel, JS, Truong, V, Frampton, E, Curtis, C, Skoczylas, R, Davidson, T-L, Miura, N, Hong, Y-k, Koopman, P, Harvey, NL & Francois, M 2014, 'Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo', Developmental Biology, vol. 386, no. 1, pp. 25-33. Open access 38 34
2014	Kartopawiro, J, Bower, N I, Karnezis, T, Kazenwadel, J, Betterman, KL, Lesieur, E, Koltowska, K, Astin, J, Crosier, P, Vermeren, S, Achen, MG, Stacker, SA, Smith, KA, Harvey, NL, Francois, M & Hogan, BM 2014, 'Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development', Human Molecular Genetics, vol. 23, no. 5, pp. 1286-1297. Open access 25 24
2013	Paterson, EL, Kazenwadel, J, Bert, AG, Khew-Goodall, Y, Ruszkiewicz, A & Goodall, GJ 2013, 'Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression', Neoplasia, vol. 15, no. 2, pp. 180-191. Open access 149 139
2012	Kazenwadel, J, Secker, GA, Betterman, KL & Harvey, NL 2012, 'In vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGRF1 signalling in lymphangiogenesis', PLoS One, vol. 7, no. 7, article no. 0040497, pp. 1-12. Open access 37 35
2012	Kazenwadel, J, Secker, GA, Liu, YJ, Rosenfeld, JA, Chong, C-E, Scott, HS & Harvey, NL and 14 other authors 2012, 'Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature', Blood, vol. 119, no. 5, pp. 1283-1291. Open access 242 213
2011	Bastian, I, Tam, TS, Zhou, X-F, Kazenwadel, J, Van Der Hoek, M, Michael, MZ, Gibbins, I & Haberberger, RV 2011, 'Differential expression of microRNA-1 in dorsal root ganglion neurons', Histochemistry and Cell Biology, vol. 135, no. 1, pp. 37-45. 16 15
2010	Kazenwadel, J, Michael, MZ & Harvey, NL 2010, 'Prox1 expression is negatively regulated by miR-181 in endothelial cells', Blood, vol. 116, no. 13, pp. 2395-2401. Open access 139 137

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Baker Heart and Diabetes Institute	AUSTRALIA
Centre Hospitalier Universitaire Vaudois	SWITZERLAND
de Duve Institute	BELGIUM
Ecole Polytechnique	FRANCE
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Francis Crick Institute	UNITED KINGDOM
Hamamatsu University	JAPAN
Hamamatsu University School of Medicine	JAPAN
Hanson Centre for Cancer Research	AUSTRALIA
KTH Royal Institute of Technology	SWEDEN
Max Planck Society	GERMANY
Northwestern University Feinberg School of Medicine	UNITED STATES
Perkin Elmer Pty Ltd	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
St George's University of London	UNITED KINGDOM
Tianjin Medical University	CHINA
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Edinburgh	UNITED KINGDOM
University of Helsinki	FINLAND
University of Melbourne	AUSTRALIA
University of Münster	GERMANY
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Sydney	AUSTRALIA
University of Toronto	CANADA
University of Washington	UNITED STATES
Uppsala University	SWEDEN
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Investigator Grant (EL1) NHMRC	2025
Investigator Grant (EL1) NHMRC	2024
Invited speaker Australian Vascular Biology Society	2024
Early Career Researcher Award Australian Vascular Biology Society	2021

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Understanding how lymphatic vessel identity is programmed during development and disease	Current
Understanding the genetic and developmental basis of human lymphatic vascular disease	Current

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Dr Jan Kazenwadel

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Investigator Grant (EL1)

Investigator Grant (EL1)

Invited speaker

Early Career Researcher Award

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery