Dr Jan Kazenwadel

Research Fellow Centre for Cancer Biology

City West Campus (HB10-25)
tel +61 8 830 27907

email Jan.Kazenwadel@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Medical and Health Sciences
Biological Sciences
Clinical Sciences
Cardiovascular Medicine and Haematology
Immunology

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2022	Byrne, AB, Brouillard, P, Sutton, DL, Kazenwadel, J, Montazaribarforoush, S, Secker, GA, Oszmiana, A, Babic, M, Betterman, KL, Brautigan, PJ, Hahn, CN, Arts, P, Scott, HS & Harvey, NL and 18 other authors 2022, 'Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema', Science Translational Medicine, vol. 14, no. 634, article no. eabm4869, pp. 1-14. 1 1 194
2020	Betterman, KL, Sutton, DL, Secker, GA, Kazenwadel, J, Oszmiana, A, Lim, L, Miura, N, Sorokin, L, Hogan, BM, Kahn, ML, McNeill, H & Harvey, NL 2020, 'Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow', Journal of Clinical Investigation, online, pp. 1-15. Open access 24 24 23
2015	Kazenwadel, J, Betterman, KL, Chong, C-E, Stokes, PH, Lee, YK, Secker, GA, Agalarov, Y, Demir, CS, Lawrence, DM, Sutton, DL, Tabruyn, SP, Miura, N, Salminen, M, Petrova, T, Matthew, JM, Hahn, CN, Scott, HS & Harvey, NL 2015, 'GATA2 is required for lymphatic vessel valve development and maintenance', Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994. Open access 129 123 6
2012	Kazenwadel, J, Secker, GA, Liu, YJ, Rosenfeld, JA, Chong, C-E, Scott, HS & Harvey, NL and 14 other authors 2012, 'Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature', Blood, vol. 119, no. 5, pp. 1283-1291. Open access 202 187
2010	Kazenwadel, J, Michael, MZ & Harvey, NL 2010, 'Prox1 expression is negatively regulated by miR-181 in endothelial cells', Blood, vol. 116, no. 13, pp. 2395-2401. Open access 122 124

Journal Articles

Year	Output
2022	Byrne, AB, Brouillard, P, Sutton, DL, Kazenwadel, J, Montazaribarforoush, S, Secker, GA, Oszmiana, A, Babic, M, Betterman, KL, Brautigan, PJ, Hahn, CN, Arts, P, Scott, HS & Harvey, NL and 18 other authors 2022, 'Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema', Science Translational Medicine, vol. 14, no. 634, article no. eabm4869, pp. 1-14. 1 1 194
2020	Betterman, KL, Sutton, DL, Secker, GA, Kazenwadel, J, Oszmiana, A, Lim, L, Miura, N, Sorokin, L, Hogan, BM, Kahn, ML, McNeill, H & Harvey, NL 2020, 'Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow', Journal of Clinical Investigation, online, pp. 1-15. Open access 24 24 23
2018	Frye, M, Taddei, A, Dierkes, C, Martinez-Corral, I, Fielden, M, Ortsater, H, Kazenwadel, J, Calado, DP, Ostergaard, P, Salminen, M, He, L, Harvey, NL, Kiefer, F & Makinen, T 2018, 'Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program', Nature Communications, vol. 9, no. 1, article no. 1511, pp. 1-16. Open access 66 68 30
2018	Kazenwadel, J & Harvey, NL 2018, 'Lymphatic endothelial progenitor cells: origins and roles in lymphangiogenesis', Current Opinion in Immunology, vol. 53, pp. 81-87. 14 13 3
2016	Kazenwadel, J & Harvey, NL 2016, 'Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels', Developmental Dynamics, vol. 245, no. 3, pp. 209-219. Open access 21 24 4
2015	Kazenwadel, J, Betterman, KL, Chong, C-E, Stokes, PH, Lee, YK, Secker, GA, Agalarov, Y, Demir, CS, Lawrence, DM, Sutton, DL, Tabruyn, SP, Miura, N, Salminen, M, Petrova, T, Matthew, JM, Hahn, CN, Scott, HS & Harvey, NL 2015, 'GATA2 is required for lymphatic vessel valve development and maintenance', Journal of Clinical Investigation, vol. 125, no. 8, pp. 2979-2994. Open access 129 123 6
2014	Bowles, J, Secker, GA, Nguyen, C, Kazenwadel, JS, Truong, V, Frampton, E, Curtis, C, Skoczylas, R, Davidson, T-L, Miura, N, Hong, Y-k, Koopman, P, Harvey, NL & Francois, M 2014, 'Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo', Developmental Biology, vol. 386, no. 1, pp. 25-33. Open access 31 28
2014	Kartopawiro, J, Bower, N I, Karnezis, T, Kazenwadel, J, Betterman, KL, Lesieur, E, Koltowska, K, Astin, J, Crosier, P, Vermeren, S, Achen, MG, Stacker, SA, Smith, KA, Harvey, NL, Francois, M & Hogan, BM 2014, 'Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development', Human Molecular Genetics, vol. 23, no. 5, pp. 1286-1297. Open access 21 19
2013	Paterson, EL, Kazenwadel, J, Bert, AG, Khew-Goodall, Y, Ruszkiewicz, A & Goodall, GJ 2013, 'Down-regulation of the miRNA-200 family at the invasive front of colorectal cancers with degraded basement membrane indicates EMT is involved in cancer progression', Neoplasia, vol. 15, no. 2, pp. 180-191. Open access 141 110
2012	Kazenwadel, J, Secker, GA, Betterman, KL & Harvey, NL 2012, 'In vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGRF1 signalling in lymphangiogenesis', PLoS One, vol. 7, no. 7, article no. 0040497, pp. 1-12. Open access 33 33 1
2012	Kazenwadel, J, Secker, GA, Liu, YJ, Rosenfeld, JA, Chong, C-E, Scott, HS & Harvey, NL and 14 other authors 2012, 'Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature', Blood, vol. 119, no. 5, pp. 1283-1291. Open access 202 187
2011	Bastian, I, Tam, TS, Zhou, X-F, Kazenwadel, J, Van Der Hoek, M, Michael, MZ, Gibbins, I & Haberberger, RV 2011, 'Differential expression of microRNA-1 in dorsal root ganglion neurons', Histochemistry and Cell Biology, vol. 135, no. 1, pp. 37-45. 14 13
2010	Kazenwadel, J, Michael, MZ & Harvey, NL 2010, 'Prox1 expression is negatively regulated by miR-181 in endothelial cells', Blood, vol. 116, no. 13, pp. 2395-2401. Open access 122 124

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Centre Hospitalier Universitaire Vaudois	SWITZERLAND
de Duve Institute	BELGIUM
Ecole Polytechnique	FRANCE
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Francis Crick Institute	UNITED KINGDOM
Hamamatsu University	JAPAN
Hamamatsu University School of Medicine	JAPAN
Hanson Centre for Cancer Research	AUSTRALIA
KTH Royal Institute of Technology	SWEDEN
Max Planck Society	GERMANY
Perkin Elmer Pty Ltd	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
SA Pathology	AUSTRALIA
St Georges University of London	UNITED KINGDOM
Tianjin Medical University	CHINA
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Edinburgh	UNITED KINGDOM
University of Helsinki	FINLAND
University of Melbourne	AUSTRALIA
University of Muenster	GERMANY
University of Pennsylvania	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Sydney	AUSTRALIA
University of Toronto	CANADA
University of Washington	UNITED STATES
Uppsala University	SWEDEN

External engagement & recognition

Engagement/recognition	Year
Early Career Researcher Award Australian Vascular Biology Society	2021

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Understanding how lymphatic vessel identity is programmed during development and disease	Current

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Dr Jan Kazenwadel

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Early Career Researcher Award

Teaching & student supervision

Courses and programs

Research degree supervision

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