Mr John Toubia

Centre for Cancer Biology Centre for Cancer Biology

email John.Toubia@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Biochemistry and Cell Biology
Biological Sciences
Medical and Health Sciences
Clinical Sciences
Oncology and Carcinogenesis

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Byrne, AB, Arts, P, Ha, TT, Kassahn, KS, Babic, M, Frank, MS, Feng, J, Wang, P, Lawrence, DM, Eshraghi, L, Arriola, L, Toubia, J, Gardner, AE, Morrow, R, Schreiber, AW, King-Smith, SL, Jackson, MR & Scott, HS 182 other authors and 2 consortia 2023, 'Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death', Nature Medicine, vol. 29, no. 1, pp. 180-189. Open access 4 3 82
2023	Conn, VM, Gabryelska, M, Toubia, J, Kirk, K, Powell, JA, Cildir, G, Samaraweera, SE, Bailey, S, Liu, D, Wallington-Gates, CT, D'Andrea, RJ, Pitson, SM, Goodall, GJ & Conn, SJ and 15 other authors 2023, 'Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia', Cancer Cell, vol. 41, no. 7, pp. 1309-1326. 5
2023	Kan, WL, Dhagat, U, Kaufmann, KB, Hercus, TR, Toubia, J, Barry, EF, Gomez, GA, Dottore, M, Samaraweera, SE, Goodall, GJ, Thomas, D, Tvorogov, D, D'Andrea, RJ & Lopez, AF and 12 other authors 2023, 'Distinct assemblies of heterodimeric cytokine receptors govern stemness programs in leukemia', Cancer Discovery, vol. 13, no. 8, pp. 1922-1947. Open access
2023	Kazenwadel, J, Venugopal, P, Oszmiana, A, Toubia, J, Panara, V, Piltz, SG, Brown, C, Ma, W, Schreiber, AW, Koltowska, K, Taoudi, S, Thomas, PQ & Scott, HS 2023, 'A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature', Nature, vol. 614, no. 7947, pp 343-348. 5 2 170
2022	Alizadeh-Ghodsi, M, Owen, KL, Townley, SL, Zanker, D, Toubia, J, Gargett, T, Thierry, B & Selth, LA and 17 other authors 2022, 'Potent stimulation of the androgen receptor instigates a viral mimicry response in prostate cancer', Cancer Research Communications, vol. 2, no. 7, pp. 706-724. Open access 15
2022	Bassal, MA, Samaraweera, SE, Lim, K, Bernard, BA, Bailey, S, Toubia, J, Nguyen, T, Maung, KZY, Casolari, DA, Iarossi, DG, Powell, J, Pitson, S, Brown, AL, Robinson, N, Ross, DM, Gonda, TJ & D'Andrea, RJ and 10 other authors 2022, 'Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia', Nature Communications, vol. 13, article no. 2614, pp. 1-12. Open access 5 6 9
2022	Bennett, MK, Li, M, Tea, MN, Pitman, MR, Toubia, J, Wang, PP, Anderson, D, Creek, DJ, Orlowski, RZ, Gliddon, BL, Powell, JA, Wallington-Beddoe, CT & Pitson, SM 2022, 'Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition', Neoplasia, vol. 24, no. 1, pp. 1-11. Open access 10 9 3
2022	Bournazos, AM, Riley, LG, Bommireddipalli, S, Ades, L, Cooper, ST & Toubia, J and 104 other authors and 1 consortium 2022, 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, vol. 24, no. 1, pp. 130-145. 27 21
2022	Kollis, PM, Ebert, LM, Toubia, J, Bastow, CR, Ormsby, RJ, Poonnoose, S I, Lenin, S, Tea, MN, Pitson, SM, Gomez, GA, Brown, MP & Gargett, T 2022, 'Characterising distinct migratory profiles of infiltrating T-Cell subsets in human glioblastoma', Frontiers in Immunology, vol.13, pp. 1-19. Open access 7 6
2021	Fernandes, RC, Toubia, J, Townley, S, Hanson, AR, Dredge, BK, Pillman, KA, Bert, AG, Gregory, PA, Goodall, GJ & Selth, LA and 12 other authors 2021, 'Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer', Cell Reports, vol. 34, no. 1, article no. 108585, pp. 1-24. Open access 21 19 124
2021	Jensen, KB, Dredge, BK, Toubia, J, Jin, X, Iadevaia, V, Goodall, GJ & Proud, CG 2021, 'capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome', Nucleic Acids Research, vol. 49, no. 18, pp. e105 -1-e105-15. Open access 11 8 13
2021	Prompsy, PB, Toubia, J, Gearing, LJ, Knight, RL, Forster, SC, Bracken, CP & Gantier, MP 2021, 'Making use of transcription factor enrichment to identify functional microRNA-regulons', Computational and Structural Biotechnology Journal, vol. 19, pp. 4896-4903. Open access 2 2 2
2020	Ebert, LM, Yu, W, Gargett, T, Toubia, J, Kollis, PM, Tea, MN, Ebert, BW, Bonder, CS, Oksdath Mansilla, M, Scheer, KG, Perrin, SL, Pitson, SM, Gomez, GA & Brown, MP and 8 other authors 2020, 'Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy', Clinical and Translational Immunology, vol. 9, no. 10, article no. e1191. Open access 30 24 5
2020	McCalmont, H, Li, KL, Jones, L, Toubia, J, Bray, SC, Casolari, DA, Mayoh, C, Samaraweera, SE, Lewis, ID, Prinjha, RK, Smithers, N, Wang, S & Lock, RB 2020, 'Efficacy of combined CDK9/BET inhibition in preclinical models of MLL-rearranged acute leukemia', Blood Advances, vol. 4, no. 2, pp. 296-300. Open access 17 17
2020	Saunders, K, Bert, AG, Dredge, BK, Toubia, J, Gregory, PA, Pillman, KA, Goodall, GJ & Bracken, CP 2020, 'Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing', Scientific Reports, vol. 10, no. 1, pp. 1-9. Open access 7 7 9
2019	Baek, S, Oh, TG, Secker, G, Sutton, DL, Okuda, KS, Paterson, S, Bower, N I, Toubia, J, Koltowska, K, Capon, SJ, Baillie, GJ, Simons, C, Muscat, GE, Lagendijk, AK, Smith, KA, Harvey, NL & Hogan, BM 2019, 'The alternative splicing regulator nova2 constrains vascular erk signaling to limit specification of the lymphatic lineage', Developmental Cell, vol. 49, no. 2, pp. 279-292.e5. Open access 22 21 12
2019	Cildir, G, Toubia, J, Yip, KH, Zhou, M, Pant, H, Hissaria, P, Zhang, J, Hong, W, Robinson, N, Grimbaldeston, MA, Lopez, AF & Tergaonkar, V 2019, 'Genome-wide analyses of chromatin state in human mast cells reveal molecular drivers and mediators of allergic and inflammatory diseases', Immunity, vol. 51, no. 5, pp. 949-965.e6. Open access 32 30 12
2019	Dorstyn, L, Hackett-Jones, E, Nikolic, A, Norris, MD, Lim, Y, Toubia, J, Haber, M & Kumar, S 2019, 'Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling', Cell Death and Disease, vol. 10, no. 2, pp. 1-16. Open access 2 2 6
2019	Pillman, KA, Scheer, KG, Hackett-Jones, E, Saunders, K, Bert, AG, Toubia, J, Whitfield, HJ, Sapkota, S, Sourdin, L, Pham, H, Le, TD, Cursons, J, Davis, MJ, Gregory, PA, Goodall, GJ & Bracken, CP 2019, 'Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA)', Nucleic Acids Research, vol. 47, no. 16, pp. 8606-8619. Open access 5 4 5
2018	Cursons, J, Pillman, KA, Scheer, KG, Gregory, PA, Foroutan, M, Hediyeh-Zadeh, S, Toubia, J, Crampin, EJ, Goodall, GJ, Bracken, CP & Davis, MJ 2018, 'Combinatorial targeting by microRNAs co-ordinates post-transcriptional control of EMT', Cell Systems, vol. 7, no. 1, pp. 77-91. Open access 63 56 34
2018	Pillman, KA, Phillips, CA, Roslan, S, Toubia, J, Dredge, BK, Bert, AG, Lumb, R, Neumann, DP, Li, X, Conn, SJ, Liu, D, Bracken, CP, Lawrence, DM, Schreiber, AW, Khew-Goodall, Y, Goodall, GJ & Gregory, PA and 4 other authors 2018, 'miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking', The EMBO Journal, vol. 37, no. 13, article no. e99016, pp. 1-20. Open access 62 60 15
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 61 56 85
2017	Yu, F, Pillman, KA, Neilsen, CT, Toubia, J, Lawrence, DM, Tsykin, A, Gantier, MP, Callen, DF, Goodall, GJ & Bracken, CP 2017, 'Naturally existing isoforms of miR-222 have distinct functions', Nucleic Acids Research, vol. 45, no. 19, pp. 1137-11385. Open access 53 49 6
2016	Plett, D, Baumann, U, Schreiber, AW, Holtham, L, Kalashyan, E, Toubia, J, Nau, J, Beatty, M, Rafalski, A, Dhugga, KS, Tester, M, Garnett, T & Kaiser, BN 2016, 'Maize maintains growth in response to decreased nitrate supply through a highly dynamic and developmental stage-specific transcriptional response', Plant Biotechnology Journal, vol. 14, no. 1, pp. 342-353. Open access 16 13
2016	Plett, D, Holtham, L, Baumann, U, Kalashyan, E, Francis, K, Enju, A, Toubia, J, Roessner, U, Bacic, A, Rafalski, A, Dhugga, K, Tester, M, Garnett, T & Kaiser, B 2016, 'Nitrogen assimilation system in maize is regulated by developmental and tissue-specific mechanisms', Plant Molecular Biology: An International Journal on Molecular Biology, Molecular Genetics and Biochemistry, vol. 92, no. 3, pp. 293-312. 13

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Adelaide Oncology and Haematology	AUSTRALIA
A-Star, Institute of Molecular and Cell Biology	SINGAPORE
Central Queensland University	AUSTRALIA
DuPont	UNITED STATES
DuPont Pioneer Hi-Bred International	UNITED STATES
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Genentech, Inc.	UNITED STATES
GlaxoSmithKline	AUSTRALIA
Harvard University	UNITED STATES
Hudson Institute of Medical Research	AUSTRALIA
Kids Research Institute	AUSTRALIA
King Abdullah University of Science and Technology	SAUDI ARABIA
Monash University	AUSTRALIA
Northwestern University Feinberg School of Medicine	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St Vincent's Hospital	AUSTRALIA
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
University Health Network	CANADA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Surrey	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Texas	UNITED STATES
Uppsala University	SWEDEN
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Enhanced bioinformatics and machine learning for improved risk stratification and outcome prediction in chronic myeloid leukaemia	Current

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Mr John Toubia

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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