Dr Leanne De Kock

Research Fellow Centre for Cancer Biology

email Leanne.DeKock@unisa.edu.au

About me

Research Fellow at the University of South Australia with Prof. Hamish Scott's Molecular Pathology Research Laboratory applying advanced genomic technologies to improve diagnosis and care of families with rare genetic diseases, including bone marrow failure and blood cancers, as well as recurrent pregnancy loss. Former Postdoctoral Research Fellow with Dr. Kym Boycott's Care4Rare Canada Consortium at the CHEO Research Institute in Ottawa, Canada. My PhD was completed in the laboratory of Dr William Foulkes at McGill University in Montreal, Canada, on the genetics of DICER1 syndrome.

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Clinical Sciences
Paediatrics and Reproductive Medicine
Biological Sciences
Genetics
Medical and Health Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2021	Foulkes, WD, de Kock, L & Priest, JR 2021, 'Dicer1 syndrome', in D Malkin (ed.), The Hereditary Basis of Childhood Cancer, Springer, Switzerland, ch. 9, pp. 227-265.

Journal Articles

Year	Output
2024	Denisenko, E, de Kock, L, Tan, A, Beasley, AB & Forrest, ARR and 17 other authors 2024, 'Spatial transcriptomics reveals discrete tumour microenvironments and autocrine loops within ovarian cancer subclones', Nature Communications, vol. 15, no. 1, article no. 2860, pp. 1-15. Open access 43 42
2024	de Kock, L, Cuillerier, A, Gillespie, M, Couse, M & Boycott, KM and 17 other authors 2024, 'Molecular characterization of 13 patients with PIK3CA-related overgrowth spectrum using a targeted deep sequencing approach', American Journal of Medical Genetics Part A, vol. 194, no. 3, article no. e63466, pp. 1-10. 2 2
2023	Amuzu, S, Fu, L, Demko, N, Rivera, B, Domecq, C, de Kock, L, Hamel, N, Gilbert, L, Polak, P, Ragoussis, J & Foulkes, WD 2023, 'Long-term tumour dormancy in a BRCA1 heterozygote', Journal of Medical Genetics, vol. 60, no. 1, pp. 33-35. 4 3
2023	Apellaniz-Ruiz, M, Sabbaghian, N, Chong, AL, de Kock, L, Cetinkaya, S, Bayramoğlu, E, Dinjens, WN, McCluggage, WG, Wagner, A, Yilmaz, AA & Foulkes, WD 2023, 'Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis', Familial Cancer, vol. 22, no. 4, pp. 487-493. Open access 5 4
2023	Hartley, T, Soubry, E, Acker, M, Osmond, M, de Kock, L & Boycott, KM and 67 other authors 2023, 'Bridging clinical care and research in Ontario, Canada: maximizing diagnoses from reanalysis of clinical exome sequencing data', Clinical Genetics: An International Journal of Genetics and Molecular Medicine, vol. 103, no. 3, pp. 288-300. 7 8
2022	Chong, A-S, Apellaniz-Ruiz, M, de Kock, L, Bouron-Dal Soglio, D, Doyle, WR, Priest, JR, Rivera, B & Foulkes, WD 2022, 'Likely foregut endoderm origin for a postzygotic mutation affecting the RNase IIIb domain of DICER1', Journal of Medical Genetics, vol. 59, no. 7, pp. 723-726. 1 1
2022	McCluggage, WG, Fu, L, Mohler, K, de Kock, L, Sabbaghian, N, Mindlin, A, Stewart, CJ, Gilks, CB & Foulkes, WD 2022, 'An unusual Enteric Yolk Sac Tumor: first report of an ovarian germ cell tumor associated with a germline pathogenic variant in DICER1', International Journal of Gynecological Pathology, vol. 41, no. 4, pp. 349-355. 4 3
2022	Ponten, E, Frisk, S, Taylan, F, Vaz, R, Wessman, S, de Kock, L, Pal, N, Foulkes, WD, Lagerstedt-Robinson, K & Nordgren, A 2022, 'A complex DICER1 syndrome phenotype associated with a germline pathogenic variant affecting the RNase IIIa domain of DICER1', Journal of Medical Genetics, vol. 59, no. 2, pp. 141-146. Open access 13 12
2021	Bennett, JA, Ordulu, Z, Young, RH, Pinto, A, Van de Vijver, K, Burandt, E, Wanjari, P, Shah, R, de Kock, L, Foulkes, WD, McCluggage, WG, Ritterhouse, LL & Oliva, E 2021, 'Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations', Modern Pathology, vol. 34, no. 9, pp. 1750-1762. 28 25
2021	Liu, AP, Kelsey, MM, Sabbaghian, N, Park, S-H, de Kock, L & Priest, JR and 15 other authors 2021, 'Clinical Outcomes and Complications of Pituitary Blastoma', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 2, pp. 351-363. Open access 35 26
2021	Nadaf, J, de Kock, L, Chong, A-S, Korbonits, M, Thorner, P, Benlimame, N, Fu, L, Peet, A, Warner, J, Ploner, O, Shuangshoti, S, Albrecht, S, Hamel, N, Priest, JR, Rivera, B, Ragoussis, J & Foulkes, WD 2021, 'Molecular characterization of DICER1-mutated pituitary blastoma', Acta Neuropathologica, vol. 141, no. 6, pp. 929-944. 24 20
2021	Niedziela, M, Sabbaghian, N, De Kock, L & Foulkes, WD 2021, 'Intrathyroidal Thymus (Incidentaloma) Mimicking Thyroid Neoplasia in DICER1 Syndrome', European Thyroid Journal, vol. 10, no. 3, pp. 257-261. 2 2
2021	Yoon, JY, de Kock, L, Stewart, CJ, McCluggage, WG, Foulkes, WD, Clarke, BA & Rouzbahman, M 2021, 'Endometrial Stem/Progenitor cell (ES/PC) Marker Expression Profile in Adenosarcoma and Endometrial Stromal Sarcoma', Cancer Treatment and Research Communications, vol. 27, article no. 100363, pp. 1-8. Open access 1
2020	Denisenko, E, Guo, BB, Jones, M, Hou, R, De Kock, L, Lassmann, T, Poppe, D, Clément, O, Simmons, RK, Lister, R & Forrest, AR 2020, 'Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows', Genome Biology, vol. 21, article no. 130, pp. 1-25. Open access 397 377
2020	McCluggage, WG, Chong, A-L, de Kock, L & Foulkes, WD 2020, 'Somatic tumour testing establishes that bilateral DICER1-associated ovarian Sertoli-Leydig cell tumours represent independent primary neoplasms', Histopathology, vol. 77, no. 2, pp. 223-230. 11 9
2020	Rivera, B, Nadaf, J, Fahiminiya, S, Apellaniz-Ruiz, M, De Kock, L & Foulkes, WD and 26 other authors 2020, 'DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis', Journal of Clinical Investigation, vol. 130, no. 3, pp. 1479-1490. 45 40
2020	Stewart, CJR, Amanuel, B, De Kock, L, Apellaniz-Ruiz, M, Carrello, A, Giardina, T, Grieu-Iacopetta, F, Thomas, MA & Foulkes, WD 2020, 'Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases', Pathology, vol. 52, no. 6, pp. 686-693. 15 14
2020	de Kock, L, Priest, JR, Foulkes, WD & Alexandrescu, S 2020, 'Update on the central nervous system manifestations of DICER1 syndrome', Acta Neuropathologica, vol. 139, no. 4, pp. 689-701. 97 76
2020	de Kock, L, Yoon, JY, Apellaniz-Ruiz, M, Pelletier, D, McCluggage, WG, Stewart, CJ, Dickson, BC, Rouzbahman, M, Clarke, BA & Foulkes, WD 2020, 'Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma', Modern Pathology, vol. 33, no. 6, pp. 1207-1219. 53 45
2019	de Kock, L, Wu, MK & Foulkes, WD 2019, 'Ten years of DICER1 mutations: Provenance, distribution, and associated phenotypes', Human Mutation, vol. 40, no. 11, pp. 1939-1953. 108 93
2018	Apellaniz-Ruiz, M, De Kock, L, Sabbaghian, N, Guaraldi, F, Ghizzoni, L, Beccuti, G & Foulkes, WD 2018, 'Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame DICER1 deletion', European Journal of Endocrinology, vol. 178, no. 2, pp. K11-K19. 25 22
2018	Bouron-Dal Soglio, D, de Kock, L, Gauci, R, Sabbaghian, N, Thomas, E, Atkinson, HC, Pachter, N, Ryan, S, Walsh, JP, Kumarasinghe, MP, Carpenter, K, Aydogan, A, Stewart, CJR, Foulkes, WD & Choong, CS 2018, 'A case report of syndromic multinodular goitre in adolescence: Exploring the phenotype overlap between cowden and DICER1 syndromes', European Thyroid Journal, vol. 7, no. 1, pp. 44-50. Open access 4 4
2018	Saskin, A, de Kock, L, Sabbaghian, N, Apellaniz-Ruiz, M, Bozkurt, C, Bouron-Dal Soglio, D & Foulkes, WD 2018, 'A case of neuroblastoma in DICER1 syndrome: chance finding or noncanonical causation?', Pediatric Blood and Cancer, vol. 65, no. 1 article no. e26715, pp. 1-4. 11 9
2018	Van Der Tuin, K, De Kock, L, Kamping, EJ, Hannema, SE, Pouwels, MJM, Niedziela, M, Van Wezel, T, Hes, FJ, Jongmans, MC, Foulkes, WD & Morreau, H 2018, 'Clinical and molecular characteristics may alter treatment strategies of thyroid malignancies in DICER1 syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 2, pp. 277-284. 34 29
2018	Wasserman, JD, Sabbaghian, N, Fahiminiya, S, Chami, R, Mete, O, Acker, M, Wu, MK, Shlien, A, De Kock, L & Foulkes, WD 2018, 'DICER1 Mutations are frequent in adolescent-onset papillary thyroid carcinoma', Journal of Clinical Endocrinology and Metabolism, vol. 103, no. 5, pp. 2009-2015. 103 91
2018	de Kock, L, Geoffrion, D, Rivera, B, Wagener, R, Sabbaghian, N, Bens, S, Ellezam, B, Bouron-Dal Soglio, D, Ordóñez, J, Sacharow, S, Polo Nieto, JF, Guillerman, RP, Vujanic, GM, Priest, JR, Siebert, R & Foulkes, WD 2018, 'Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion', Genes Chromosomes and Cancer, vol. 57, no. 5, pp. 223-230. 40 36

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Belfast Health and Social Care Trust	UNITED KINGDOM
Bilkent University	TÜRKIYE
British Columbia Cancer Agency	CANADA
Centre universitaire de santé McGill (CUSM)	CANADA
Children's Hospital Colorado	UNITED STATES
Chulalongkorn University	THAILAND
Craigavon Area Hospital	UNITED KINGDOM
Diakonie-Klinikum Stuttgart	GERMANY
Edith Cowan University	AUSTRALIA
Harvard University	UNITED STATES
Karolinska Institute	SWEDEN
Karolinska University Hospital	SWEDEN
McGill University	CANADA
Mount Sinai Hospital	UNITED STATES
Poznan University of Medical Sciences	POLAND
Private Individual	UNITED KINGDOM
Public University of Navarre	SPAIN
Seoul National University Gwanak Campus	KOREA, REPUBLIC OF (SOUTH)
Sidra Medicine	QATAR
Sir Charles Gardiner Hospital	AUSTRALIA
Sir Mortimer B. Davis Jewish General Hospital	CANADA
Sonic Healthcare	UNITED STATES
St. Jude Children's Research Hospital	UNITED STATES
Texas Children's Hospital	UNITED STATES
The Hospital for Sick Children	CANADA
Toronto General Hospital	CANADA
University Health Network	CANADA
University Hospital Ghent	BELGIUM
University Hospital of Wales	UNITED KINGDOM
University Medical Center Hamburg-Eppendorf	GERMANY
University of Barcelona	SPAIN
University of Birmingham	UNITED KINGDOM
University of Bologna	ITALY
University of British Columbia	CANADA
University of Chicago Medical Center	UNITED STATES
University of London	FRANCE
University of Miami	UNITED STATES
University of Montreal	CANADA
University of Ottawa	CANADA
University of Pennsylvania	UNITED STATES
University of Toronto	CANADA
University of Turin	ITALY
University of Ulm	GERMANY
University of Western Australia	AUSTRALIA

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Dr Leanne De Kock

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

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