Dr Louise Smith

Adjunct Research Fellow Future Industries Institute

Mawson Lakes Campus (MM3-02B)
tel +61 8 830 23639

email Louise.Smith@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Chemical Sciences
Physical Sciences
Biological Sciences
Clinical Sciences
Technology

Highlights

My research focusses on the development of biomaterials primarily for wound healing applications. At a fundamental level I am interested in the interactions between cells and material surfaces. These interactions include cell attachment, cell detachment, cell migration and the development of materials to encourage specific responses. For wound healing; reepithelialisation and angiogenesis, and for immunotherapies; T cell activation. I also use and develop 3-dimensional human skin models to evaluate the cytotoxicity of materials as well as the ability of the novel materials to influence wound healing.

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2016	Smith, L 2016, 'Modelling of cell-tissue interactions in skin', in MS Ågren (ed.), Wound healing biomaterials, Woodhead Publishing, UK, vol. 2, pp. 39-54. 1
2008	Smith, LE, Collins, S, Liu, Z, MacNeil, S, Williams, R & Rimmer, S 2008, 'Synthesis and Properties of Functional Poly(vinylpyrrolidinone) Hydrogels for Drug Delivery', in Anil Mahapatro, Polymers for Biomedical Applications , 11, American Chemical Society, Washington DC, ch.11, pp. 196-203.

Journal Articles

Year	Output
2023	Strudwick, XL, Whittle, JD, Cowin, AJ & Smith, LE 2023, 'Plasma-functionalised dressings for enhanced wound healing', International Journal of Molecular Sciences, vol. 24, no. 1, article no. 797, pp. 1-13. Open access
2022	Elsemary, MT, Maritz, MF, Smith, LE, Warkiani, M, Bandara, V, Napoli, S, Barry, SC, Coombs, JT & Thierry, B 2022, 'Inertial microfluidic purification of CAR-T-Cell products', Advanced Biology, vol. 6, no. 1, article no. 2101018, pp. 1-12. 1 1 1
2022	Milky, B, Zabolocki, M, Al-Bataineh, SA, van den Hurk, M, Greenberg, Z, Turner, L, Mazzachi, P, Williams, A, Illeperuma, I, Adams, R, Stringer, BW, Ormsby, R, Poonnoose, S, Smith, LE, Krasowska, M, Whittle, JD, Simula, A & Bardy, C 2022, 'Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings', Stem Cell Reports, vol. 17, no. 3, pp. 489-506. Open access 4 3 64
2021	Ahangar, P, Mills, S, Smith, L, Strudwick, X, Ting, A, Vaes, B & Cowin, A 2021, 'Treatment of murine partial thickness scald injuries with multipotent adult progenitor cells decreases inflammation and promotes angiogenesis leading to improved burn injury repair', Wound Repair and Regeneration, vol. 29, no. 3, pp. 380-392. Open access 18
2021	Dabare, PRL, Bachhuka, A, Visalakshan, RM, Shirazi, HS, Ostriko, K, Smith, LE & Vasilev, K 2021, 'Mechanistic insight in surface nanotopography driven cellular migration', ACS Biomaterial Science and Engineering, vol. 7, no. 10, pp. 4921-4932. 1 1
2020	Ahangar, P, Mills, SJ, Smith, LE, Gronthos, S & Cowin, AJ 2020, 'Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms', npj Regenerative Medicine, vol. 5, no. 1, article no. 24, pp. 1-10. Open access 25 22 5
2020	Ahangar, P, Mills, SJ, Smith, LE, Strudwick, XL, Ting, AE, Vaes, B & Cowin, AJ 2020, 'Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice', Stem Cell Research and Therapy, vol. 11, no. 1, article no. 299, pp. 1-16. Open access 12 12 22
2020	Kirby, GT, Mills, SJ, Mueller, TE, Ting, AE, Cowin, AJ, Michelmore, A & Smith, L 2020, 'Improved recovery of cryopreserved cell monolayers with a hyaluronic acid surface treatment', BioInterphases: An Open Access Journal for the Biomaterials Interface Community, vol. 15, no. 6, article no. 061015, pp. 1-9. Open access 1 1
2019	McCormick, S, Smith, LE, Holmes, AM, Tong, Z, Lombi, E, Voelcker, NH & Priest, C 2019, 'Multiparameter toxicity screening on a chip: effects of UV radiation and titanium dioxide nanoparticles on HaCaT cells', Biomicrofluidics, vol. 13, no. 4, article no. 044112, pp. 044112-1-044112-8. Open access 3 3 35
2018	Fernandez, T, Strudwick, X, Al-Bataineh, S, Short, R, Cowin, A, Whittle, J & Smith, L 2018, 'Surfaces to enhance matrix deposition for wound healing', Wound Practice and Research, vol. 26, no. 4, pp. 201-209. Open access 1
2018	Kirby, GT, Michelmore, A, Smith, LE, Whittle, JD & Short, RD 2018, 'Cell sheets in cell therapies', Cytotherapy, vol. 20, pp. 169-180. Open access 19 18 4
2017	Bachhuka, A, Hayball, JD, Smith, LE & Vasilev, KA 2017, 'The interplay between surface nanotopography and chemistry modulates collagen I and III deposition by human dermal fibroblasts', ACS Applied Materials and Interfaces, vol. 9, pp. 5874-5884. 17 17 2
2017	Kirby, GT, Mills, SJ, Vandenpoel, L, Pinxteren, J, Ting, A, Short, RD, Cowin, AJ, Michelmore, A & Smith, LE 2017, 'Development of advanced dressings for the delivery of progenitor cells', ACS Applied Materials and Interfaces, vol. 9, no. 4, pp. 3445-3454. 9 9 9
2016	Robinson, DE, Al-Bataineh, SA, Farrugia, BL, Michelmore, A, Cowin, AJ, Dargaville, TR, Short, RD, Smith, LE & Whittle, JD 2016, 'Plasma polymer and biomolecule modification of 3D scaffolds for tissue engineering', Plasma Processes and Polymers, vol. 13, no. 7, pp. 678-689. Open access 18 16 1
2016	Ryssy, J, Prioste-Amaral, E, Assuncao, DF, Rogers, N, Kirby, GT, Smith, LE & Michelmore, A 2016, 'Chemical and physical processes in the retention of functional groups in plasma polymers studied by plasma phase mass spectroscopy', Physical Chemistry Chemical Physics, vol. 18, no. 6, pp. 4496-4504. Open access 19 19 5
2016	Smith, LE, Bryant, C, Krasowska, M, Cowin, AJ, Whittle, JD, MacNeil, S & Short, RD 2016, 'Haptotatic plasma polymerized surfaces for rapid tissue regeneration and wound healing', ACS Applied Materials and Interfaces, vol. 8, no.48 , pp. 32675-32687. 9 10
2015	Bachhuka, A, Christo, S, Cavallaro, A, Diener, K, Mierczynska, A, Smith, L, Marian, R, Manavis, J, Hayball, J & Vasilev, KA 2015, 'Hybrid core/shell microparticles and their use for understanding biological processes', Journal of Colloid and Interface Science, vol. 457, pp. 9-17. Open access 16 16 1
2015	Bachhuka, A, Hayball, JD, Smith, LE & Vasilev, KA 2015, 'Effect of surface chemical functionalities on collagen deposition by primary human dermal fibroblasts', ACS Applied Materials and Interfaces, vol. 74, no. 42, pp. 23767-23775. 27 27 1
2015	Daunton, C, Smith, LE, Whittle, JD, Short, RD, Steele, DA & Michelmore, A 2015, 'Plasma parameter aspects in the fabrication of stable amine functionalized plasma polymer films', Plasma Processes and Polymers, vol. 12, no. 8, pp. 817, 826. 24 22
2015	Kirby, G, Mills, S, Cowin, AJ & Smith, L 2015, 'Stem cells for cutaneous wound healing', BioMed Research International, vol. 2015, article no.285869 pp. 1-11. Open access 66 53 4
2015	Smith, L, Whittle, J & Short, R 2015, 'Surface optimisation for enhanced cell culture', Cytotherapy, vol. 17, no. 6, pp. S75-S75.
2015	Strudwick, XL, Lang, DL, Smith, LE & Cowin, AJ 2015, 'Combination of low calcium with Y-27632 rock Inhibitor increases the proliferative capacity, expansion potential and lifespan of primary human keratinocytes while retaining their capacity to differentiate into stratified epidermis in a 3D skin model', PLoS One, vol. 10, no. 4, article no. e0123651, pp. 1-12. Open access 30 28 9
2014	Robinson, DE, Smith, LE, Steele, DA, Short, RD & Whittle, JD 2014, 'Development of a surface to enhance the effectiveness of fibroblast growth factor 2 (FGF-2)', Biomaterials Science, vol. 2, no. 6, pp. 875-882. 8 9
2014	Taheri, S, Cavallaro, A, Barton, M, Whittle, J, Majewski, P, Smith, L & Vasilev, K 2014, 'Antibacterial efficacy and cytotoxicity of silver-nanoparticle–based coatings facilitated by a plasma deposited polymer interlayer', Plasma Medicine, vol. 4, pp. 101-115. Open access 5
2014	Taheri, S, Cavallaro, AA, Christo, S, Smith, L, Majewski, P, Barton, M, Hayball, J & Vasilev, K 2014, 'Substrate independent silver nanoparticle based antibacterial coatings', Biomaterials, vol. 35, no. 16, pp. 4601-4609. 116 107 5
2013	Goreham, R V, Mierczynska-Vasilev, A, Smith, LE, Sedev, R & Vasilev, K 2013, 'Small surface nanotopography encourages fibroblast and osteoblast cell adhesion', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 3, no. 26, pp. 10309-10317. 55 54
2013	Hopp, I, Michelmore, AP, Smith, LE, Robinson, DE, Bachhuka, A, Mierczynska, A & Vasilev, KA 2013, 'The influence of substrate stiffness gradients on primary human dermal fibroblasts', Biomaterials, vol. 34, no. 21, pp. 5070-5077. 77 71
2012	Daunton, C, Kothari, S, Smith, L & Steele, D 2012, 'A history of materials and practices for wound management', Wound Practice and Research, vol. 20, no. 4, pp. 174-186.
2012	Goreham, R V, Mierczynska, A, Pierce, M, Short, RD, Taheri, S, Bachhuka, A, Cavallaro, A, Smith, LE & Vasilev, K 2012, 'A substrate independent approach for generation of surface gradients', Thin Solid Films, vol. 528, pp. 106-110. 49 48
2012	Mitchell, E & Smith, L 2012, 'Cell responses to plasma polymers - implications for wound care', Wound Practice and Research, vol. 20, no. 2, pp. 74-79.
2011	Smith, LE, Hearnden, V, Lu, Z, Smallwood, R, Hunter, KD, Matcher, SJ, Thornhill, MH, Murdoch, C & MacNeil, S 2011, 'Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro', Journal of Biomedical Optics, vol. 16, no. 11, pp. 116015-1-116015-8. Open access 13 13
2010	Greenwood, PD, Childs, DT, Kennedy, K, Groom, KM, Hugues, M, Hopkinson, M, Hogg, RA, Krstajic, N, Smith, LE, Matcher, SJ, Bonesi, M, MacNeil, S & Smallwood, R 2010, 'Quantum dot superluminescent diodes for optical coherence tomography: device engineering', IEEE Journal of Selected Topics in Quantum Electronics, vol. 16, no. 4, pp. 1015-1022. Open access 47 43
2010	Krstajic, N, Smith, LE, Matcher, SJ, Childs, DT, Bonesi, M, Greenwood, PDL, Hugues, M, Kennedy, K, Hopkinson, M, Groom, KM, MacNeil, S, Hogg, RA & Smallwood, R 2010, 'Quantum dot superluminescent diodes for optical coherence tomography: skin imaging', IEEE Journal of Selected Topics in Quantum Electronics, vol. 16, no. 4, pp. 748-754. 32 30
2010	Smith, LE, Bonesi, M, Smallwood, R, Matcher, SJ & MacNeil, S 2010, 'Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin', Journal of Tissue Engineering and Regenerative Medicine, vol. 4, no. 8, pp. 652-658. 26 22
2010	Smith, LE, Smallwood, R & MacNeil, S 2010, 'A comparison of imaging methodologies for 3D tissue engineering', Microscopy Research and Technique, vol. 73, no. 12, pp. 1123-1133. 64 59

Conferences

Year	Output
2016	Visalakshan, RM, Cavallaro, A, Smith, LE, MacGregor-Ramiasa, M, Hayball, J & Vasilev, K 2016, 'Downstream influences of oxazoline plasma polymerisation conditions on chemical and biological interactions', Chemeca conference 2016, Engineers Australia, article no. 3405675, pp. 840-848.
2010	Kasaragod, D, Lu, Z, Smith, LE & Matcher, S 2010, 'Speckle texture analysis of optical coherence tomography images', in AA Goncalves Jr. (ed.), Speckle 2010: Optical Metrology, SPIE, vol. 7387 article no. 73871V, pp. 1-7. 4 3
2010	Smith, LE, Lu, Z X, Bonesi, M, Smallwood, R, Matcher, S & MacNeil, S 2010, 'Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin', in SJ Kirkpatrick & R Wang (eds), SPIE 2010 - Optics in Tissue Engineering and Regenerative Medicine IV, The International Society for Optical Engineering - SPIE, vol. 7566, article no. 75660I, pp. 1-9. 8 3
2008	Krstajic, N, Jacobs, J, Bonesi, M, Smith, LE, Deshpande, P, MacNeil, S, Smallwood, R & Matcher, S 2008, 'Ex vivo and in vivo OCT image contrast ', 1st Canterbury Workshop on Optical Coherence Tomography and Adaptive Optics, International Society for Optical Engineering, pp. 71390W. 2

Research

Patents

Details	Registry	Status
Methods and products for delivering cells Smith, Louise; Michelmore, Andrew Percival; Kirby, Giles Thomas Sipho; Cowin, Allison June; Mills, Stuart James; Short, Robert David	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Athersys Inc	UNITED STATES
Athersys, Inc.	UNITED STATES
Carina Biotech	AUSTRALIA
Centro Federal de Educacao Tecnologica	BRAZIL
College of Medicine and Public Health	AUSTRALIA
Federal University of Sao Carlos	BRAZIL
Flinders University	AUSTRALIA
Kroto Research Institute	UNITED KINGDOM
Medical University of Vienna	AUSTRIA
Monash University	AUSTRALIA
Queensland University of Technology	AUSTRALIA
ReGenesys	SOUTH AFRICA
SA Pathology	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
TekCyte Limited	AUSTRALIA
The Australian Wine Research Institute	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Liverpool	UNITED KINGDOM
University of Nottingham	UNITED KINGDOM
University of Sheffield	UNITED KINGDOM
University of South Australia	AUSTRALIA
University of Technology Sydney	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
Wound Management Innovation CRC	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
An infrared spectroscopic study of fucoidan/chitosan polyelectrolyte multilayers for biomedical applications	Completed
Development of stem cell therapies for the treatment of wounds	Completed
High throughput screening of nanotoxicity using microfluidics	Completed
Microfluidic manufacturing of chimeric antigen receptor t-cells	Completed
The effect of nanotopography on cell-surface interaction	Completed

more less

Dr Louise Smith

About me

About me

Future Industries Institute

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Chapters

Journal Articles

Conferences

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery