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Dr Manuela Klingler-Hoffmann

  • Research Fellow Future Industries Institute
  • Mawson Lakes Campus (MM3-01)
  • tel +61 8 830 23465
  • email Manuela.Klingler-Hoffmann@unisa.edu.au
  • Research Degree Supervisor
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About me

About me

Dr Manuela Klingler-Hoffmann

Dr Manuela Klingler-Hoffmann is an experienced cell biologist and biochemist with a background in biophysics. Her passion in science is translational cancer research; the kind of research, which will make a positive impact to patient’s treatment and life expectancy. In 2018 she joined the Future Industries Institute, where she leads a small and dedicated team working on translational research projects in gynaecological cancers. Dr Manuela Klingler-Hoffmann has extensive experiences in a wide array of cell biology, proteomics and mass spectrometry techniques as well as in research design and project management. She is passionate about gender equity and was a member of the self-assessment team for SAGE... Read more

Future Industries Institute

The Institute partners with today’s industries, to create the industries of tomorrow.

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About me

Dr Manuela Klingler-Hoffmann is an experienced cell biologist and biochemist with a background in biophysics. Her passion in science is translational cancer research; the kind of research, which will make a positive impact to patient’s treatment and life expectancy. In 2018 she joined the Future Industries Institute, where she leads a small and dedicated team working on translational research projects in gynaecological cancers. Dr Manuela Klingler-Hoffmann has extensive experiences in a wide array of cell biology, proteomics and mass spectrometry techniques as well as in research design and project management. She is passionate about gender equity and was a member of the self-assessment team for SAGE (http://u.unisa.edu.au/about/sage-pilot).

After finishing her PhD in 1999 at the German Cancer Research Centre in Heidelberg, Germany, she has been awarded a prestigious DFG (German Research Foundation) fellowship to work at Monash University in Melbourne. After her time at Monash University, she has been working part time in several laboratories around the world and had a number of career interruptions. In 2016 she was the recipient of a Barbara Kidman Fellowship, which aims to enhance and promote the career of female academics. She has co-supervised more than a dozen Honour’s students and PhD students and numerous vacation scholarship students; with multiple winning internal and external awards, such as the University medal for best the PhD thesis in Biological Sciences. 

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Professional Associations

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Experience

Qualifications

  • Doctor of Natural Sciences University of Saarland

  • Bachelor of Science in Biology University of Saarland

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  • Experience
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Research

Research themes

  • Cancer

Research focus

  • Biological Sciences
  • Clinical Sciences
  • Biochemistry and Cell Biology
  • Chemical Sciences
  • Genetics
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Research

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Projects

Excludes commercial-in-confidence projects.

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Research

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Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year Output
2019

Briggs, MT, Condina, MR, Klingler-Hoffmann, M, Arentz, G, Everest-Dass, A V, Kaur, G, Oehler, MK, Packer, NH & Hoffmann, P 2019, 'Translating N‐glycan analytical applications into clinical strategies for ovarian cancer', Proteomics - Clinical Applications, vol. 13, no. 3, article no. 1800099, pp. 1-15.

Open access 3 1 2
2019

Condina, MR, Mittal, P, Briggs, MT, Oehler, MK, Klingler-Hoffmann, M & Hoffmann, P 2019, 'Egg White as a Quality Control in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI)', Analytical Chemistry, vol. 91, no. 23, pp. 14846-14853.

2019

Klingler-Hoffmann, M, Mittal, P & Hoffmann, P 2019, 'The emerging role of cytoskeletal proteins as reliable biomarkers', Proteomics, online, pp. 1-16.

Open access
2019

Mittal, P, Price, ZK, Lokman, NA, Ricciardelli, C, Oehler, MK, Klingler-Hoffmann, M & Hoffmann, P 2019, 'Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for monitoring of drug response in primary cancer spheroids', Proteomics, online, pp. 1-4.

2018

Acland, M, Mittal, P, Lokman, NA, Klingler-Hoffmann, M, Oehler, MK & Hoffmann, P 2018, 'Mass spectrometry analyses of multicellular tumor spheroids', Proteomics - Clinical Applications, vol. 12, no. 3, article no. 1700124 , pp. 1-13.

Open access 7 5 1
2017

Amare, A, Schubert, K, Klingler-Hoffmann, M, Cohen-Woods, S & Baune, B 2017, 'The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies', Translational Psychiatry, vol. 7, no. 1, article no. e1007, pp. 1-12.

Open access 59 59 7
2017

Mittal, P, Klingler-Hoffmann, M, Arentz, G, Winderbaum, L, Kaur, G, Anderson, L, Scurry, J, Leung, Y, Stewart, CJ, Carter, J, Hoffmann, P & Oehler, MK 2017, 'Annexin A2 and alpha actinin 4 expression correlates with metastatic potential of primary endometrial cancer', BBA: Proteins and Proteomics, vol. 1865, no. 7, pp. 846-857.

7 8 1
2016

Barnett, CP, Nataren, NJ, Klingler-Hoffmann, M, Schwarz, Q, Chong, C-E, Lee, YK, Bruno, DL, Lipsett, J, McPhee, AJ, Schreiber, AW, Feng, J, Hahn, CN & Scott, HS 2016, 'Ectrodactyly and lethal pulmonary acinar dysplasia associated with homozygous FGFR2 mutations identified by exome sequencing', Human Mutation, vol. 37, no. 9, pp. 955-963.

Open access 9 8 1
2016

Mittal, P, Klingler-Hoffmann, M, Arentz, G, Winderbaum, L, Lokman, NA, Zhang, C, Anderson, L, Scurry, J, Leung, Y, Stewart, CJ, Carter, J, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Lymph node metastasis of primary endometrial cancers: associated proteins revealed by MALDI imaging', Proteomics, vol. 16, no. 11-12, pp. 1793-1801.

11 8 10
2016

Mittal, P, Klingler-Hoffmann, M, Arentz, G, Zhang, C, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Proteomics of endometrial cancer diagnosis, treatment, and prognosis', Proteomics - Clinical Applications, vol. 10, no. 3, pp. 217-229.

8 8 10
2016

Weiland, F, Arentz, G, Klingler-Hoffmann, M, McCarthy, P, Lokman, N, Kaur, G, Oehler, MK & Hoffmann, P 2016, 'Novel IEF peptide fractionation method reveals a detailed profile of N-terminal acetylation in chemotherapy-responsive and -resistant ovarian cancer cells', Journal of Proteome Research, vol. 15, no. 11, pp. 4073-4081.

Open access 3 3 1
2016

Zhang, C, Arentz, G, Winderbaum, L, Lokman, NA, Klingler-Hoffmann, M, Mittal, P, Carter, C, Oehler, MK & Hoffmann, P 2016, 'MALDI mass spectrometry imaging reveals decreased CK5 levels in vulvar squamous cell carcinomas compared to the precursor lesion differentiated vulvar intraepithelial neoplasia', International Journal of Molecular Sciences, vol. 17, no. 7, article no. 1088, pp. 1-12.

Open access 6 3 7
2015

Hahn, C, Brautigan, P, Chong, C-E, Janssan, A, Venugopal, P, Lee, Y, Tims, A, Horwitz, M, Klingler-Hoffmann, M & Scott, H 2015, 'Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia', Leukemia, vol.29, no.8, pp. 1795-1797.

3 3
2015

Turvey, ME, Klingler-Hoffmann, M, Hoffmann, P & McColl, SR 2015, 'p84 forms a negative regulatory complex with p110ɣ to control PI3Kɣ signalling during cell migration', Immunology and Cell Biology, vol. 93, no. 8, pp. 735-743.

5 5 10
2014

Humphries, JM, Penno, MA, Weiland, F, Klingler-Hoffmann, M, Zuber, A, Boussioutas, A, Ernst, M & Hoffmann, P 2014, 'Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer', BBA: Proteins and Proteomics, vol. 1844, no. 5, pp. 1051-1058.

29 30 31
2013

Niu, M, Klingler-Hoffmann, M, Brazzatti, JA, Forbes, B, Akekawatchai, C, Hoffmann, P & McColl, SR 2013, 'Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line', Proteome Science, vol. 11, no. 4, pp. 1-12.

Open access 7 3
2013

Sciacca, B, Francois, A, Klingler-Hoffmann, M, Brazzatti, J, Penno, M, Hoffmann, P & Monro, TM 2013, 'Radiative-surface plasmon resonance for the detection of apolipoprotein E in medical diagnostics applications', Nanomedicine: Nanotechnology Biology and Medicine, vol. 9, no. 4, pp. 550-557.

Open access 33 27 1
2012

Brazzatti, J, Klingler-Hoffmann, M, Haylock-Jacobs, S, Harata-Lee, Y, Niu, M, Higgins, M, Kochetkova, M, Hoffmann, P & McColl, S 2012, 'Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis', Oncogene, vol. 31, no. 18, pp. 2350-2361.

Open access 35 33 3
2012

Penno, MA, Klingler-Hoffmann, M, Brazzatti, JA, Boussioutas, A, Putoczki, T, Ernst, M & Hoffmann, P 2012, '2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer', Journal of Proteomics, vol. 77, pp. 40-58.

23 21 1
2011

Haylock-Jacobs, S, Comerford, I, Bunting, M, Kara, E, Townley, S, Klingler-Hoffmann, M, Vanhaesebroeck, B, Puri, KD & McColl, SR 2011, 'PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation', Journal of Autoimmunity, vol. 36, no. 3-4, pp. 278-287.

59 56 6
2010

Condina, MR, Gustafsson, JO, Klingler-Hoffmann, M, Bagley, CJ, McColl, SR & Hoffmann, P 2010, 'EZYprep LC-coupled MALDI-TOF/TOF MS: an improved matrix spray application for phosphopeptide characterisation', Proteomics, vol. 10, no. 13, pp. 2516-2530.

5 5 6
2010

Condina, MR, Klingler-Hoffmann, M & Hoffmann, P 2010, 'Tyrosine phosphorylation enrichment and subsequent analysis by MALDI-TOF/TOF MS/MS and LC-ESI-IT-MS/MS', Current Protocols in Protein Science, vol. 62, article number 13.11, pp. 13.11.1 - 13.11.26.

3

Conferences

Year Output
2015

François, A, Sciacca, B, Klantsataya, E, Zuber, A, Hoffmann, P, Klinger-Hoffmann, M & Monro, T 2015, 'Surface plasmon scattering: An alternative approach for optical fibers biosensors', in B Lee, Y Rao & S Lee (eds), 5th Asia-Pacific Optical Sensors Conference, SPIE - International Society for Optical Engineering, vol. 9655, pp. 1-4.

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External engagement & recognition

Collaborations

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Collaborations

Organisation Country
Calistoga Pharmaceuticals Inc. UNITED STATES
Chris O'Brien Lifehouse AUSTRALIA
Griffith University AUSTRALIA
Ludwig Institute for Cancer Research AUSTRALIA
Macquarie University AUSTRALIA
Murdoch Childrens Research Institute AUSTRALIA
Queen Mary University of London UNITED KINGDOM
Royal Adelaide Hospital AUSTRALIA
Royal Prince Alfred Hospital AUSTRALIA
SA Pathology AUSTRALIA
Thammasat University THAILAND
University of Adelaide AUSTRALIA
University of Manchester UNITED KINGDOM
University of Melbourne AUSTRALIA
University of New South Wales AUSTRALIA
University of Science, Malaysia MALAYSIA
University of South Australia AUSTRALIA
University of Washington UNITED STATES
University of Western Australia AUSTRALIA
Walter and Eliza Hall Institute of Medical Research AUSTRALIA
Women's and Children's Hospital AUSTRALIA
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Dr Manuela Klingler-Hoffmann
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