Please note Dr. Sykes works across both City East and West campuses (P5-27 and HB5-27). It is advisable to contact him in advance to check which campus he is at on a given day.
Matt completed a Bachelor of Science honours degree in chemistry at Flinders University and subsequently completed a PhD at the same institution working in the field of molecular property prediction with Dr. Errol McCoy. After completing his PhD Matt worked as a Postdoctoral Research Associate at the University of Sheffield in the UK and at Astra Zeneca pharmaceuticals in Alderley Edge, Cheshire with Professor Barry Pickup and Dr Andrew Grant. This work centred around developing computational tools to expedite the drug development process, in particular looking at areas related to solvation of small molecules and proteins.
Prior to moving to UniSA, Matt was working as a Research Fellow in the Department of Clinical Pharmacology at... Read more
About me
Matt completed a Bachelor of Science honours degree in chemistry at Flinders University and subsequently completed a PhD at the same institution working in the field of molecular property prediction with Dr. Errol McCoy. After completing his PhD Matt worked as a Postdoctoral Research Associate at the University of Sheffield in the UK and at Astra Zeneca pharmaceuticals in Alderley Edge, Cheshire with Professor Barry Pickup and Dr Andrew Grant. This work centred around developing computational tools to expedite the drug development process, in particular looking at areas related to solvation of small molecules and proteins.
Prior to moving to UniSA, Matt was working as a Research Fellow in the Department of Clinical Pharmacology at Flinders University with Professor John Miners, looking at computer-based methods for screening, identification and analysis of molecules of importance to human hepatic drug metabolism.
Matt has won a number of awards for his teaching including: Division of Health Sciences Teaching Award (2009) Nominee, Student Nominated Excellent Educator Award (2010) University Supported Teacher Award (2011) UniSA Citation for Outstanding Contribution to Student Learning for "For sustained excellence in the teaching of chemistry to large first year student cohorts from a diverse range of programs and backgrounds" (2015)
About me
About me
Doctor of Philosophy Flinders University of SA
Bachelor of Science (Honours) Flinders University of SA
Bachelor of Science Flinders University of SA
Research
Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus
Open access indicates that an output is open access.
| Year | Output |
|---|---|
| 2017 |
14
15
2
|
| 2015 |
29
26
4
|
| 2014 |
Open access
71
69
1
|
| 2008 |
69
66
|
| Year | Output |
|---|---|
| 2024 |
1
3
|
| 2023 |
9
9
1
|
| 2023 |
Open access
3
2
|
| 2023 |
2
3
|
| 2023 |
Open access
2
1
2
|
| 2022 |
Open access
5
5
|
| 2022 |
Open access
9
12
4
|
| 2022 |
5
4
2
|
| 2022 |
Open access
17
18
2
|
| 2021 |
Open access
26
20
4
|
| 2021 |
Open access
7
6
10
|
| 2021 |
21
22
|
| 2020 |
7
8
|
| 2019 |
Open access
20
19
1
|
| 2019 |
6
4
|
| 2018 |
2
2
1
|
| 2017 |
Open access
2
1
|
| 2017 |
14
15
2
|
| 2016 |
22
20
|
| 2015 |
36
38
9
|
| 2015 |
20
14
12
|
| 2015 |
Open access
27
25
6
|
| 2015 |
29
26
4
|
| 2014 |
Open access
71
69
1
|
| 2014 |
41
39
6
|
| 2013 |
Open access
12
11
|
| 2013 |
27
25
|
| 2013 |
27
26
|
| 2012 |
Open access
5
5
|
| 2010 |
15
14
|
| 2010 |
11
10
|
| 2008 |
Open access
12
11
|
| 2008 |
69
66
|
Research
External engagement & recognition
| Organisation | Country |
|---|---|
| Chuulangun Aboriginal Corporation | AUSTRALIA |
| Flinders Medical Centre | AUSTRALIA |
| Flinders University | AUSTRALIA |
| Liaocheng University | CHINA |
| Lincoln University | NEW ZEALAND |
| Shandong First Medical University | CHINA |
| Shandong University | CHINA |
| Swinburne University of Technology | AUSTRALIA |
| The Australian Wine Research Institute | AUSTRALIA |
| University of Adelaide | AUSTRALIA |
| University of Bonn | GERMANY |
| University of Cologne | GERMANY |
| University of Copenhagen | DENMARK |
| University of Melbourne | AUSTRALIA |
| University of Queensland | AUSTRALIA |
| University of South Australia | AUSTRALIA |
| Women's and Children's Hospital | AUSTRALIA |
| Yabao Pharmaceutical Group Co., Ltd | CHINA |
External engagement & recognition
| Engagement/recognition | Year |
|---|---|
FellowshipRoyal Australian Chemical Institute (RACI) |
2021 |
New Colombo Plan Grant: The Global Nature of the Pharmaceutical Industry and the Pharmacy Profession in the Philippines.Department of Foreign Affairs and Trade |
2021 |
Opening Keynote Speaker: 1st International Congress on Collaborative Education and Research in HealthcareUniversity of Santo Tomas. Manila, Philippines |
2021 |
FellowshipRoyal Australian Chemical Institute (RACI) |
2020 |
Honorary General Treasurer and Chair of Finance CommitteeRoyal Australian Chemical Institute (RACI) |
2020 |
New Colombo Plan Grant: The Global Nature of the Pharmaceutical Industry and the Pharmacy Profession in the Philippines.Department of Foreign Affairs and Trade |
2020 |
FellowshipRoyal Australian Chemical Institute (RACI) |
2019 |
Honorary General Treasurer and Chair of Finance CommitteeRoyal Australian Chemical Institute (RACI) |
2019 |
New Colombo Plan Grant: The Global Nature of the Pharmaceutical Industry and the Pharmacy Profession in the Philippines.Department of Foreign Affairs and Trade |
2019 |
FellowshipRoyal Australian Chemical Institute (RACI) |
2018 |
New Colombo Plan Grant: The Global Nature of the Pharmaceutical Industry and the Pharmacy Profession in the Philippines.Department of Foreign Affairs and Trade |
2018 |
FellowshipRoyal Australian Chemical Institute (RACI) |
2017 |
MemberAdelaide Pharmacology Group |
2017 |
Board MemberRoyal Australian Chemical Institute |
2016 |
Board MemberRoyal Australian Chemical Institute |
2015 |
Board MemberRoyal Australian Chemical Institute |
2014 |
Board Member: National Tertiary Education Union
Peer reviewer of manuscripts submitted for publication in: Bioinformatics, Journal of Medicinal Chemistry, Medicinal Chemistry Letters, Journal of Chemical Information and Modeling, Journal of Biochemical Pharmacology, Bioorganic and Medicinal Chemistry, Nucleic Acids Research, Letters in Drug Design and Discovery, Journal of Computer-Aided Molecular Design and Journal of Pharmaceutical and Biomedical Analysis.
Teaching & student supervision
Teaching & student supervision
Supervisions from 2010 shown
| Thesis title | Student status |
|---|---|
| A computational approach to improve the prediction of fraction unbound to enhance pharmacokinetic (PK) and biopharmaceutic models | Current |
| DECR1 Inhibition; a novel prostate cancer therapeutic target | Current |
| Design and synthesis of mnk Inhibitors for targeted cancer therapy | Current |
| Enriching pharmacoepidemiology with molecular similarity approaches in order to support adverse event detection | Current |
| Evaluation of the cyclin-dependent kinase CDK inhibitors resistance for cancer treatment | Current |
| Molecular modeling of calpain inhibitors | Current |
| Targeting tankyrases for the treatment of cancer | Current |
| A combined in silico and microbiological approach for the identification of novel efflux pump inhibitors against AcrAB-TolC | Completed |
| An integrated molecular modelling and pharmacoepidemiological data-driven approach for adverse drug event signal detection and evaluation | Completed |
| Derivatives of 4-(1H-pyrazol-4-yl)pyrimidine CDK2 inhibitors as potential anticancer agents: design, synthesis & evaluation | Completed |
| Discovery and evaluation of MNK inhibitors as potential anti-cancer agents | Completed |
| Discovery and evaluation of styrylsulfonyl-methylpyridine derivatives as anticancer agents | Completed |
| Discovery of cyclin-dependent kinase 2/5 inhibitors for the potential treatment of cancer | Completed |
| Discovery of novel cyclin-dependent kinase 8 inhibitors as potential antitumour agents | Completed |
| Discovery of protein kinase inhibitors as potential anti-cancer agents | Completed |
| Pharmacological and in silico investigation of anti-inflammatory diterpenoid compounds isolated from Dodonaea polyandra | Completed |
| Reversing multi-drug resistance with efflux pump inhibitors | Completed |
