Dr Melinda Tea

Research Fellow Centre for Cancer Biology

City West Campus (HB10-27)
tel +61 8 830 27896

email Melinda.Tea@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Clinical Sciences
Immunology
Biochemistry and Cell Biology
Cardiovascular Medicine and Haematology
Oncology and Carcinogenesis

Research

Projects

Excludes commercial-in-confidence projects.

Overcoming the blood-brain barrier for improved brain tumour therapy, Fay Fuller Foundation, 01/07/2024 - 30/06/2027
A new therapeutic approach for glioblastoma, Brain Foundation - Annual Research Awards, 01/01/2025 - 31/12/2025
Understanding the biology of treatment resistant brain tumours so that new therapeutic approaches can be developed, Neurosurgical Research Foundation, 04/07/2024 - 31/12/2025
New approaches to enhance immunotherapy for brain tumours, NHMRC - Ideas Grants, 01/01/2023 - 31/12/2025
Targeting sphingosine kinase 1 as a novel therapeutic strategy in childhood medulloblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Pre-clinical evaluation of sphingosine kinase 2 inhibitors as new glioblastoma therapeutics, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Developing clinically relevant models of recurrent glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Inhibiting ER-stress induced CD47 to treat Glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Stereotactic alignment and injection system for the generation of xenografts of human brain tumours into the brains of mice for pre-clinical testing of new and existing therapeutics, Neurosurgical Research Foundation, 01/01/2018 - 31/12/2018

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Li, M, Bennett, MK, Toubia, J, Pope, VS, Tea, MN, Tamang, S, Samuel, MS, Anderson, PH, Gliddon, BL, Powell, JA & Pitson, SM 2024, 'An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma', British Journal of Haematology, 204, no. 2, pp. 566-570. Open access 1 1 1
2024	Yu, W, Truong, NT, Polara, R, Gargett, T, Tea, MN, Pitson, SM, Cockshell, MP, Bonder, CS, Ebert, LM & Brown, MP 2024, 'Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma', Clinical and Translational Immunology, vol. 13, no. 7, pp. 1-20. Open access 3 2 4
2022	Bennett, MK, Li, M, Tea, MN, Pitman, MR, Toubia, J, Wang, PP, Anderson, D, Creek, DJ, Orlowski, RZ, Gliddon, BL, Powell, JA, Wallington-Beddoe, CT & Pitson, SM 2022, 'Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition', Neoplasia, vol. 24, no. 1, pp. 1-11. Open access 15 14 3
2022	Gargett, T, Ebert, LM, Truong, NT, Kollis, PM, Sedivakova, K, Yu, W, Yeo, EC, Wittwer, NL, Gliddon, BL, Tea, MN, Ormsby, R, Poonnoose, S, Nowicki, J, Vittorio, O, Ziegler, DS, Pitson, SM & Brown, MP 2022, 'GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma', Journal for ImmunoTherapy of Cancer, vol. 10, no. 9, article no. e005187, pp. 1-15. Open access 64 61
2022	Kollis, PM, Ebert, LM, Toubia, J, Bastow, CR, Ormsby, RJ, Poonnoose, S I, Lenin, S, Tea, MN, Pitson, SM, Gomez, GA, Brown, MP & Gargett, T 2022, 'Characterising distinct migratory profiles of infiltrating T-Cell subsets in human glioblastoma', Frontiers in Immunology, vol.13, pp. 1-19. Open access 21 18
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 31 28 70
2021	Lenin, S, Ponthier, E, Scheer, KG, Yeo, EC, Tea, MN, Ebert, LM, Mansilla, MO, Poonnoose, S, Baumgartner, U, Day, BW, Ormsby, RJ, Pitson, SM & Gomez, GA 2021, 'A drug screening pipeline using 2d and 3d patient-derived in vitro models for pre-clinical analysis of therapy response in glioblastoma', International Journal of Molecular Sciences, vol. 22, no. 9, article no. 4322, pp. 1-27. Open access 33 32 5
2021	Mansilla, MO, Salazar-Hernandez, C, Perrin, SL, Scheer, KG, Cildir, G, Toubia, J, Sedivakova, K, Tea, MN, Lenin, S, Ponthier, E, Yeo, EC, Tergaonkar, V, Poonnoose, S, Ormsby, RJ, Pitson, SM, Brown, MP, Ebert, LM & Gomez, GA 2021, '3D-printed microplate inserts for long term high-resolution imaging of live brain organoids', BMC Biomedical Engineering, vol. 3, article no. 6, pp. 1-13. Open access 13
2020	Boyle, ST, Poltavets, V, Kular, J, Pyne, NT, Sandow, JJ, Lewis, AC, Murphy, KJ, Kolesnikoff, N, Moretti, PAB, Tea, MN, Tergaonkar, V, Timpson, P, Pitson, SM, Webb, AI, Whitfield, RJ, Lopez, AF, Kochetkova, M & Samuel, MS 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, vol. 22, no. 7, pp. 882-895. 55 56 849
2020	Ebert, LM, Yu, W, Gargett, T, Toubia, J, Kollis, PM, Tea, MN, Ebert, BW, Bonder, CS, Oksdath Mansilla, M, Scheer, KG, Perrin, SL, Pitson, SM, Gomez, GA & Brown, MP and 8 other authors 2020, 'Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy', Clinical and Translational Immunology, vol. 9, no. 10, article no. e1191. Open access 51 46 4
2020	Tea, MN, Poonnoose, S I & Pitson, SM 2020, 'Targeting the sphingolipid system as a therapeutic direction for glioblastoma', Cancers, vol. 12, no. 1, pp. 1-25. Open access 38 36 6
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 22 20 5
2017	Hughes, J, Dawson, R, Tea, M, McAninch, D, Piltz, S, Jackson, D, Stewart, L, Ricos, MG, Dibbens, LM, Harvey, NL & Thomas, P 2017, 'Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling', Scientific Reports, vol. 7, no. 1, article no. 12618, pp. 1-15. Open access 45 42 3
2013	Tea, M, Michael, MZ, Brereton, HM & Williams, KA 2013, 'Stability of small non-coding RNA reference gene expression in the rat retina during exposure to cyclic hyperoxia', Molecular Vision, vol. 19, pp. 501-508. Open access 20 18
2012	Colella, A, Chegenii, N, Tea, MN, Gibbins, I, Williams, K & Chataway, T 2012, 'Comparison of Stain-Free gels with traditional immunoblot loading control methodology', Analytical Biochemistry, vol. 430, no. 2, pp. 108-110. 117 116
2009	Tea, M, Fogarty, R, Brereton, HM, Michael, MZ, Van Der Hoek, MB, Tyskin, A, Coster, DJ & Williams, KA 2009, 'Gene expression microarray analysis of early oxygen-induced retinopathy in the rat', Journal of Ocular Biology, Diseases, and Informatics, vol. 2, no. 4, pp. 190-201. Open access 14
2008	Irani, Y, Tea, MN, Tilton, RG, Coster, D, Williams, K & Brereton, H 2008, 'PCR amplification of the functional immunoglobulin heavy chain variable gene from a hybridoma in the presence of two aberrant transcripts', Journal of Immunological Methods, vol. 336, no. 2, pp. 246-250. 12 12

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Monash University	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of South Australia	AUSTRALIA
University of Texas	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2018
Member Australian Society for Medical Research (ASMR)	2018
Member Australasian Microarray and Associated Technologies Association	2018
Best Poster Prize 8th Barossa Meeting: Cell Signalling in Cancer Medicine Adelaide	2017
Member Australian Society for Medical Research (ASMR)	2017
Member Australasian Microarray and Associated Technologies Association	2017
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2017
Member Australian Society for Medical Research (ASMR)	2016
Member Australasian Microarray and Associated Technologies Association	2016
Member Australian Society for Medical Research (ASMR)	2015
Member Australasian Microarray and Associated Technologies Association	2015
Member Australian Society for Medical Research (ASMR)	2014
Member Australasian Microarray and Associated Technologies Association	2014
Poster Judge Australia and New Zealand Society for Cell and Developmental Biology, Adelaide	2014
Member Australian Society for Medical Research (ASMR)	2013
Member Australasian Microarray and Associated Technologies Association	2013
Member Australasian Microarray and Associated Technologies Association	2012
Member Australian Society for Medical Research (ASMR)	2012
Member Australasian Microarray and Associated Technologies Association	2011
Member Australian Society for Medical Research (ASMR)	2011
Member Australasian Microarray and Associated Technologies Association	2010
Member Australian Society for Medical Research (ASMR)	2010
Member Australian Society for Medical Research (ASMR)	2009

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
535 - Targeting sphingolipid metabolism as a therapy for diffuse midline glioma	Current

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Dr Melinda Tea

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

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Member

Member

Best Poster Prize

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Poster Judge

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Teaching & student supervision

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