Dr Melissa Pitman

Adjunct Research Fellow Centre for Cancer Biology

City West Campus (HB10-26)
tel +61 8 830 27892

email Melissa.Pitman@unisa.edu.au

Research

Research focus

Clinical Sciences
Biochemistry and Cell Biology
Biological Sciences
Medical and Health Sciences
Oncology and Carcinogenesis

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID

Open access indicates that an output is open access.

Chapters

Year	Output
2018	Pitman, MR, Davies, LT & Pitson, SM 2018, 'An improved isoform-selective assay for sphingosine kinase 1 activity', in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate, Humana Press, Inc., US, ch. 2, pp. 9-20. 3 1

Journal Articles

Year	Output
2025	Davies, LT, Ganesen, R, Toubia, J, Hong, S-H, Kumar, KS, Oehler, MK, Ricciardelli, C, Szili, EJ, Robinson, N & Pitman, MR 2025, 'Plasma-activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high-grade serous ovarian cancer cells', Molecular Oncology, vol. 19, no. 4, pp. 1170-1187. Open access 1 1 5
2024	Calabrese, C, Nolte, H, Pitman, MR, Ganesan, R, Lampe, P, Laboy, R, Ripa, R, Fischer, J, Polara, R, Panda, SK, Chipurupalli, S, Gutierrez, S, Thomas, D, Pitson, SM, Antebi, A & Robinson, N 2024, 'Mitochondrial translocation of TFEB regulates complex I and inflammation', EMBO Reports, vol. 25, no. 2, pp. 704-724. Open access 8 8 34
2022	Bennett, MK, Li, M, Tea, MN, Pitman, MR, Toubia, J, Wang, PP, Anderson, D, Creek, DJ, Orlowski, RZ, Gliddon, BL, Powell, JA, Wallington-Beddoe, CT & Pitson, SM 2022, 'Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition', Neoplasia, vol. 24, no. 1, pp. 1-11. Open access 16 16 3
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 37 32 73
2022	Mahabaleshwar, H, Asharani, P, Loo, TY, Koh, SY, Pitman, MR, Kwok, S, Ma, J, Hu, B, Lin, F, Li Lok, X, Pitson, SM, Saunders, TE & Carney, TJ 2022, 'Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme', EMBO Reports, vol. 23, no. 8, pp. 1-14. Open access 3 3 4
2022	Pitman, MR, Lewis, AC, Davies, LT, Moretti, PA, Anderson, D, Creek, DJ, Powell, JA & Pitson, SM 2022, 'The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism', Scientific Reports, vol. 12, no. 1, article no.454, pp. 1-12. Open access 15 13 89
2021	Pham, DH, Pitman, MR, Kumar, R, Jolly, LA, Pitson, SM & Gecz, J and 16 other authors 2021, 'Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants', Human Mutation, vol. 42, no. 8, pp. 1030-1041. 1 1
2021	Pitman, MR, Oehler, MK & Pitson, SM 2021, 'Sphingolipids as multifaceted mediators in ovarian cancer', Cellular Signalling, vol. 81, article no. 109949, pp. 1-18. 15 15
2019	Al-Shujairi, WH, Clarke, JN, Davies, LT, Pitman, MR, Calvert, JK, Aloia, AL, Pitson, SM & Carr, JM 2019, 'In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection', Journal of General Virology, vol. 110, no. 4, pp. 629-641. Open access 12 11 5
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 25 22 5
2019	Powell, JA, Pitman, MR, Zebol, JR, Moretti, PA, Neubauer, HA, Davies, LT, Lewis, AC, Dagley, LF, Webb, A I, Costabile, M & Pitson, SM 2019, 'Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1', Biochemical Journal, vol. 476, no. 21, pp. 3211-3226. Open access 14 14
2017	Tran, HB, Jersmann, H, Truong, TT, Hamon, R, Roscioli, E, Ween, M, Pitman, MR, Pitson, SM, Hodge, G, Reynolds, PN & Hodge, S 2017, 'Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD', PLoS One, vol.12, no. 11, pp. 1-14. Open access 30 28 1
2017	Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616. Open access 42 40 8
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. Open access 29 27
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 30 26 8
2016	Aurelio, L, Scullino, C V, Pitman, MR, Sexton, A, Oliver, V, Davies, L, Rebello, RJ, Furic, L, Creek, DJ, Pitson, SM & Flynn, BL 2016, 'From sphingosine kinase to dihydroceramide desaturase: A structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)', Journal of Medicinal Chemistry, vol. 59, pp. 965-984. 58 53 9
2016	McNaughton, M, Pitman, M, Pitson, SM, Pyne, NJ & Pyne, S 2016, 'Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells', Oncotarget, vol. 7, no. 13, pp. 16663-16675. Open access 67 64
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 54 50
2016	Pitman, MR, Costabile, M & Pitson, SM 2016, 'Recent advances in the development of sphingosine kinase inhibitors', Cellular Signalling, vol. 28, no. 9, pp. 1349-1363. Open access 84 85 6
2016	Sun, WY, Dimasi, DP, Pitman, MR, Zhuang, Y, Heddle, R, Pitson, SM, Grimbaldeston, MA & Bonder, CS 2016, 'Topical application of fingolimod perturbs cutaneous inflammation', Journal of Immunology, vol. 196, no. 9, pp. 3854-3864. 14 13 11
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 65 64

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
A-Star, Institute of Molecular and Cell Biology	SINGAPORE
Flinders University	AUSTRALIA
Max Planck Institute for Biology of Ageing	GERMANY
Monash University	AUSTRALIA
Nanyang Technological University	SINGAPORE
National University of Singapore	SINGAPORE
QIMR Berghofer Medical Research Institute	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Cologne	GERMANY
University of Iowa	UNITED STATES
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of South Australia	AUSTRALIA
University of Strathclyde	UNITED KINGDOM
University of Texas	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

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Dr Melissa Pitman

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

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