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Dr Melissa Pitman

Centre for Cancer Biology Centre for Cancer Biology

City West Campus (HB10-26)
tel +61 8 830 27892

email Melissa.Pitman@unisa.edu.au

Research

Research focus

Biological Sciences
Clinical Sciences
Medical and Health Sciences
Oncology and Carcinogenesis
Agricultural and Veterinary Sciences

Research

Outputs

Research since 2008 is shown below.

Open access indicates that an output is open access.

Chapters

Year	Output
2018	Pitman, MR, Davies, LT & Pitson, SM 2018, 'An improved isoform-selective assay for sphingosine kinase 1 activity', in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate, Humana Press, Inc., US, ch. 2, pp. 9-20. 1

Journal Articles

Year	Output
2019	Al-Shujairi, WH, Clarke, JN, Davies, LT, Pitman, MR, Calvert, JK, Aloia, AL, Pitson, SM & Carr, JM 2019, 'In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection', Journal of General Virology, vol. 110, no. 4, pp. 629-641. Open access 3 3 2
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 8 8 5
2019	Powell, JA, Pitman, MR, Zebol, JR, Moretti, PA, Neubauer, HA, Davies, LT, Lewis, AC, Dagley, LF, Webb, A I, Costabile, M & Pitson, SM 2019, 'Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1', Biochemical Journal, vol. 476, no. 21, pp. 3211-3226. Open access 5 5
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 40 39 85
2017	Tran, HB, Jersmann, H, Truong, TT, Hamon, R, Roscioli, E, Ween, M, Pitman, MR, Pitson, SM, Hodge, G, Reynolds, PN & Hodge, S 2017, 'Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD', PLoS One, vol.12, no. 11, pp. 1-14. Open access 10 10 2
2017	Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616. Open access 20 21 7
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. Open access 19 15
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 17 15 2
2016	Aurelio, L, Scullino, C V, Pitman, MR, Sexton, A, Oliver, V, Davies, L, Rebello, RJ, Furic, L, Creek, DJ, Pitson, SM & Flynn, BL 2016, 'From sphingosine kinase to dihydroceramide desaturase: A structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)', Journal of Medicinal Chemistry, vol. 59, pp. 965-984. 27 26
2016	McNaughton, M, Pitman, M, Pitson, SM, Pyne, NJ & Pyne, S 2016, 'Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells', Oncotarget, vol. 7, no. 13, pp. 16663-16675. Open access 48 42
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 28 23
2016	Pitman, MR, Costabile, M & Pitson, SM 2016, 'Recent advances in the development of sphingosine kinase inhibitors', Cellular Signalling, vol. 28, no. 9, pp. 1349-1363. Open access 48 46 3
2016	Sun, WY, Dimasi, DP, Pitman, MR, Zhuang, Y, Heddle, R, Pitson, SM, Grimbaldeston, MA & Bonder, CS 2016, 'Topical application of fingolimod perturbs cutaneous inflammation', Journal of Immunology, vol. 196, no. 9, pp. 3854-3864. Open access 11 10 1
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 42 39

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Flinders University	AUSTRALIA
Monash University	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Stanford University	UNITED STATES
University of Adelaide	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of South Australia	AUSTRALIA
University of Strathclyde	UNITED KINGDOM
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

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