Professor Michael Fenech is recognised internationally for his research in nutritional genomics and genetic toxicology and for developing the cytokinesis-block micronucleus (CBMN) assay which is now a standard method used internationally to measure DNA damage in human and mammalian cells. The lymphocyte CBMN assay has been endorsed by the International Atomic Energy Agency and the OECD for in vivo radiation bio-dosimetry and in vitro testing of chemical genotoxicity, respectively. From 1990 to 2018 he worked as a principal research scientist in Australia at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) in the field of human nutrition. In 1999-2009 his laboratory further developed the lymphocyte CBMN assay into a... Read more
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Professor Michael Fenech is recognised internationally for his research in nutritional genomics and genetic toxicology and for developing the cytokinesis-block micronucleus (CBMN) assay which is now a standard method used internationally to measure DNA damage in human and mammalian cells. The lymphocyte CBMN assay has been endorsed by the International Atomic Energy Agency and the OECD for in vivo radiation bio-dosimetry and in vitro testing of chemical genotoxicity, respectively. From 1990 to 2018 he worked as a principal research scientist in Australia at the Commonwealth Scientific and Industrial Research Organisation (CSIRO) in the field of human nutrition. In 1999-2009 his laboratory further developed the lymphocyte CBMN assay into a 'cytome' assay consisting of six complementary biomarkers of DNA damage and cytotoxicity and, in collaboration with other laboratories, he coordinated the establishment of a similar method for buccal epithelial cells. Both methods are published in Nature Protocols. His key goal is to determine the nutritional, lifestyle and environmental requirements for DNA damage prevention. His research is focused on (i) the impact of nutrition on chromosomal and telomere integrity and (ii) personalised nutrition for healthy aging. He co-founded the HUMN project on micronuclei in human populations in 1997 and the Asia Pacific Nutrigenomics Nutrigenetics Organisation (www.apnno.com) in 2014. Since 2010 he has been an invited speaker at 57 international conferences (10 plenary lectures). His H-index is 88 based on 36,861 total career citations according to Google Scholar.
Excludes commercial-in-confidence projects.
Research since 2008 is shown below. To see earlier years visit ORCID
Open access indicates that an output is open access.
Fenech, M, Nersesyan, A & Knasmueller, S 2019, 'Effect of in vivo formaldehyde exposure on DNA damage measured by the micronucleus assay in lymphocytes, buccal, and nasal cells', in M Fenech & S Knasmuller (eds), The micronucleus assay in toxicology, The Royal Society of Chemistry, US, ch. 29, pp. 471-493.
Deo, P, Dhillon, VS, Lim, WM, Jaunay, EL, Donnellan, L, Peake, B, McCullough, C & Fenech, M 2020, 'Advanced glycation end-products accelerate telomere attrition and increase pro-inflammatory mediators in human WIL2-NS cells', Mutagenesis, online, pp. 1-7.
Deo, P, McCullough, CL, Almond, T, Jaunay, EL, Donnellan, L, Dhillon, VS & Fenech, M 2020, 'Dietary sugars and related endogenous advanced glycation end-products increase chromosomal DNA damage in WIL2-NS cells, measured using cytokinesis-block micronucleus cytome assay', Mutagenesis, online, pp. 1-9.
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Dhillon, VS, Deo, P, Chua, A, Thomas, P & Fenech, M 2020, 'Shorter telomere length in carriers of APOE-ε4 and high plasma concentration of glucose, glyoxal and other advanced glycation end products (AGEs).', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 75, no. 10, pp. 1894-1898.
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Dhillon, VS, Deo, P, Chua, A, Thomas, P & Fenech, M 2020, 'Telomere length in healthy adults is positively associated with polyunsaturated fatty acids, including arachidonic acid, and negatively with saturated fatty acids', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, online, pp. 1-20.
Fenech, M, Knasmueller, S, Bolognesi, C, Holland, N, Bonassi, S & Kirsch-Volders, M 2020, 'Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans', Mutation Research - Reviews in Mutation Research, vol. 786, article no. 108342, pp. 1-13.
Jaunay, EL, Dhillon, VS, Semple, SJ, Simpson, BS, Deo, P & Fenech, M 2020, 'Can a digital slide scanner and viewing technique assist the visual scoring for the cytokinesis-block micronucleus cytome assay?', Mutagenesis, online, pp. 1-7.
M'kacher, R, Colicchio, B, Borie, C, Junker, S, Fenech, M & Jeandidier, E and 20 other authors 2020, 'Telomere and centromere staining followed by m-fish improves diagnosis of chromosomal instability and its clinical utility', Genes, vol. 11, no. 5, article no. 475, pp. 1-17.
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Deo, P, Dhillon, VS, Chua, A, Thomas, P & Fenech, M 2019, 'APOE ε4 carriers have a greater propensity to glycation and sRAGE which is further influenced by RAGE G82S polymorphism', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 75, no. 10, pp. 1899-1905.
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Guo, X, Ni, J, Liang, Z, Xue, J, Fenech, MF & Wang, X 2019, 'The molecular origins and pathophysiological consequences of micronuclei: new insights into an age-old problem', Mutation Research - Reviews in Mutation Research, vol. 779, pp. 1-35.
Open access 12 21 5
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Dhillon, VS, Yeoh, E, Salisbury, C, Butters, J, Di Matteo, A, Olver, I & Fenech, M 2018, 'Cytokinesis block micronucleus cytome (CBMN Cyt) assay biomarkers and their association with radiation sensitivity phenotype in prostate cancer cases and DNA repair gene hOGG1 (C1245G) polymorphism', Environmental and Molecular Mutagenesis, vol. 59, no. 9, pp. 813-821.
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Yeoh, EK, Krol, R, Dhillon, V, Botten, R, Di Matteo, A, Butters, J, Brock, AR, Esterman, A, Salisbury, C & Fenech, M 2016, 'Predictors of radiation-induced gastrointestinal morbidity: a prospective, longitudinal study following radiotherapy for carcinoma of the prostate', Acta Oncologica, vol. 55, no. 5, pp. 604-610.
Open access 11 8
Main, PA, Angley, MT, O'Doherty, CE, Thomas, P & Fenech, M 2012, 'The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders : a systematic review and meta-analysis', Nutrition and Metabolism, vol. 9, article no. 35, pp. 1-37.
Open access 48 42 23
Bonassi, S, Coskun, E, Ceppi, M, Lando, C & Fenech, M and 38 other authors 2011, 'The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): the role of life-style, host factors, occupational exposures, health status, and assay protocol', Mutation Research - Reviews in Mutation Research, vol. 728, no. 3, pp. 88-97.
Fenech, M, El-Sohemy, A, Cahill, L, Ferguson, LR, French, T-A, Tai, ES, Milner, J, Koh, W-P, Xie, L, Zucker, M, Buckley, M, Cosgrove, L, Lockett, T, Fung, KY & Head, R 2011, 'Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice', Journal of Nutrigenetics and Nutrigenomics, vol. 4, no. 2, pp. 69-89.
Open access 154 131 40
Anglin, E, Davey, R, Herrid, M, Hope, S, Kurkuri, M, Pasic, P, Hor, M, Fenech, M, Thissen, H & Voelcker, N 2010, 'Cell microarrays for the screening of factors that allow the enrichment of bovine testicular cells', Cytometry. Part A : The Journal of the International Society for Analytical Cytology, vol. 77, no. 9, pp. 881-889.
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Beetstra, AJN, Suthers, GK, Dhillon, V, Salisbury, C, Turner, J, Altree, M, McKinnon, RA & Fenech, M 2008, 'Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer', Cancer Epidemiology, Biomarkers and Prevention, vol. 17, no. 10, pp. 2565-2571.
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External engagement & recognition
|CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)||AUSTRALIA|
|Groupe Hospitalier de la Région de Mulhouse et Sud Alsace Mulhouse (GHRMSA)||FRANCE|
|IRCCS San Raffaele Pisana||ITALY|
|Johns Hopkins University||UNITED STATES|
|Medical University of Vienna||AUSTRIA|
|Medical University Vienna||AUSTRIA|
|National Cancer Institute||UNITED STATES|
|National Cancer Research Institute||UNITED KINGDOM|
|National University of Singapore||SINGAPORE|
|Radboud University Nijmegen||NETHERLANDS|
|Royal Adelaide Hospital||AUSTRALIA|
|San Martino Hospital||ITALY|
|San Raffaele University||ITALY|
|South Australian Health and Medical Research Institute (SAHMRI)||AUSTRALIA|
|University in Brussels||BELGIUM|
|University of Adelaide||AUSTRALIA|
|University of Auckland||NEW ZEALAND|
|University of California, Berkeley||UNITED STATES|
|University of South Australia||AUSTRALIA|
|University of Toronto||CANADA|
|University of Upper Alsace (UHA)||FRANCE|
|Women's and Children's Health Network||AUSTRALIA|
|Yunnan Normal University||CHINA|
Supervisions from 2010 shown
|Thesis title||Student status|
|Interaction of advanced glycation end products with receptors and their effect on insulin resistance||Current|
|Investigation of extracts of Australian native food and medicinal plants against advanced glycation endproduct-induced cellular damage||Current|
|A nutrigenomic study of folate/methionine status and oxidative stress in autistic disorder||Completed|