Professor Michael Roberts

Research Chair: Therapeutics & Pharmaceutical Science School of Pharmacy and Medical Sciences

City West Campus (HB6-18)
tel +61 8 830 22815

email Michael.Roberts@unisa.edu.au

Research Degree Supervisor

About me

School of Pharmacy and Medical Sciences

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About me

Mike Roberts has a particular interest in therapeutics and pharmaceutical sciences with current studies in critical care medicine, hepatology, quality use of medicines in the community, nanotoxicology, topical delivery, renal impairment after pesticide poisoning, nicotine addiction, pharmacokinetics, drug devlopment and cosmetology. He is probably best known internationally for his work on the absorption of chemicals, cosmetics and drugs through the skin. He has been a full professor for 25 years being initially Professor and Head of Pharmacy at the University of Otago, New Zealand and now as a Senior Principal Research Fellow of the Australian National Health and Medical Research Council. He is jointly appointed as the Chair In Therapeutics and Pharmaceutical Science in the University of South Australia and as the Professor of Clinical Pharmacology and Therapeutics at the University of Queensland. He is also visiting Professeur at the University of Lyon, France and is Director of the Therapeutics Research Centre ( 30 staff and students), based jointly at the Queen Elizabeth Hospital in Adelaide and at and Princess Alexandria Hospital in Brisbane. Mike also co-chairs The Therapeutics and Pharmaceutical Science Consortium in UniSA’s Sansom Institute and leads the inaugural SA government-UniSA pharmacy practitioner program. His research journey began with an undergraduate project studying solute chemical structure-plastic container sorption relationships in the Reid Building, where his office is now located at UniSA. The resulting studies on drugs uptake by plastic containers and infusion systems are widely referred to in journal reviews, pharmacy references and text books and resulted in forms of their recommended polyolefin infusion systems being widely marketed. His PhD was on structure penetration and toxicity relationships for phenolic compounds in human skin. This work is now included as core data in pharmaceutical and toxicological data bases (eg US Environmental Protection Agency). He has served/serves on reference committees for WHO, Europe, Health Canada and Australia and presented to regulatory forums in the US. Mike’s RCTs in the community led, in part, to the Australian government national implementation of medication management for nursing homes and hostels (also now an accreditation requirement), and home medicine reviews by accredited pharmacists. Most recently, he has facilitated the use of imaging and microdialysis techniques to study pharmacokinetics in man in vitro and in vivo, including in critical care and cancer medicine.

Research

Research themes

An age friendly world
Transforming industries
Cancer
Healthy futures
Transforming societies

Research focus

Pharmacology and Pharmaceutical Sciences
Clinical Sciences
Pharmacology and Pharmacy
Public Health and Health Services
Medical Biotechnology

Highlights

I have undertaken and published peer reviewed research across a range of disciplines including: rational drug design, drug delivery (especially skin and oral), clinical pharmacokinetics, the pharmacist’s role in quality use of medicines and translation of research into practice/commercial outcomes. An overarching theme has been a mechanistic understanding of solute structure – delivery system physiological pharmacokinetic relationships and their clinical application.My predominant focus, has, however, been the skin and its interaction with chemicals, formulations and associated technologies. In recent years, I have had a keen interest in how to measure these interactions better and have embraced the use of non-invasive, high resolution,...

Research

Projects

Excludes commercial-in-confidence projects.

Improving therapeutic and toxicological outcomes, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2020
Characterization of critical quality attributes for semisolid topical drug products, US Food and Drug Administration, 09/10/2014 - 31/08/2020
Properties of nanomaterials determine their disposal by liver cells, ARC - Discovery Projects, 01/01/2017 - 31/12/2019
Physiological based biopharmaceuticals and pharmacokinetics of drug for dermal absorption in humans, US Food and Drug Administration, 10/09/2014 - 28/02/2019
An integrated research program in human toxicology to ensure rapid translation of results into practice and regulation, NHMRC - Program Grant, 01/01/2014 - 31/12/2018
Minimising treatment related toxicities in vulnerable patients using a pharmacokinetic based approach, NHMRC - Program Grant, 01/01/2018 - 31/12/2018
Optimizing sample preparation for analysis for Toxicokinetic and Toxicodynamic assessment, storage and tracking following Poison Exposures, NHMRC - Program Grant, 01/11/2016 - 31/12/2018
Closing the data gap: High throughput screening of nanoparticle toxicity, ARC - Discovery Projects, 01/01/2015 - 01/10/2018
Nanotechnology based delivery and response systems CPP28, Collaboration Pathways Program (DSD), 01/05/2014 - 30/06/2017
Refining regulatory toxicology through the integration of human clinical toxicology and mechanistic findings, Central Adelaide Local Health Network Incorporated, 04/07/2016 - 28/02/2017
Clinical toxicology of various consumer products and poisons after dermal exposure, Central Adelaide Local Health Network Incorporated, 04/07/2016 - 21/02/2017
Robust antibiotic dosing for critically ill patients receiving renal replacement therapy, NHMRC - Project Grant, 01/01/2013 - 31/12/2016
NHMRC Equip 2015 - Modification of Vivascope Imaging, NHMRC - Equipment Only Grants, 01/01/2016 - 31/12/2016
Specific targeting by cutaneous delivery, NHMRC - Project Grant, 01/01/2013 - 31/12/2015
Improving therapeutic outcomes through pharmaceutical sciences research, NHMRC - Senior Principal Research Fellowship, 01/01/2011 - 31/12/2015
Neuromuscular junction toxicity after anticholinesterase pesticide poisoning and envenomation, NHMRC - Project Grant, 01/01/2015 - 31/12/2015
Skin Penetration of Nanoparticles Promoted by Particle Design, Formulation and Application Method, ARC - Discovery Projects, 01/01/2012 - 31/12/2015
NHMRC Equipment Grant 2012 - Nikon confocal microscope and Nanosurf Lens atomic force microscope (AFM) imaging system with cell sorting, NHMRC - Equipment Only Grants, 01/01/2013 - 31/12/2013
Stable Isotope Biomarker Engineering Centre, Bio Innovation SA, 05/03/2012 - 24/06/2013
NHMRC Senior Principal Research Fellowship (Prof Michael Roberts), NHMRC - Senior Principal Research Fellowship, 01/04/2009 - 31/12/2012
NHMRC equipment grant 2011: Upgrade to Zeiss and Vivascope microscope, NHMRC - Equipment Only Grants, 01/01/2012 - 31/12/2012
NHMRC Equipment Grant 2010: Emulsiflex C3 Homogeniser, NHMRC - Equipment Only Grants, 01/01/2011 - 31/12/2012
Relationship between melanosome distribution and skin colour, ARC - Linkage Project, 01/07/2006 - 30/06/2012
Skin bioavailability and targeted skin delivery by topical application, Cancer Council South Australia, 21/07/2011 - 29/02/2012
Pharmacodynamics in liver disease and in liver surgery, NHMRC - Project Grant, 01/01/2009 - 31/12/2011
Targeted delivery by topical application, NHMRC - Project Grant, 01/01/2009 - 31/12/2011

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Books

Year	Output
2015	Flynn, GL & Roberts, MS 2015, Physical and biophysical foundations of pharmacy practice: issues in drug delivery, Michigan Publishing in partnership with the University of Michigan College of Pharmacy, US. Open access

Chapters

Year	Output
2018	Holmes, A, Thorling, C, Liu, X, Liang, X, Wang, H, Breunig, HG, König, K, Studier, H & Roberts, MS 2018, 'Revealing interaction of dyes and nanomaterials by multiphoton imaging', in K Karsten (ed.), Multiphoton microscopy and fluorescence lifetime imaging: applications in biology and medicine, Walter de Gruyter GmbH, Germany, ch. 18, pp. 345-368. Open access
2017	Grice, JE, Moghimi, HR, Ryan, E, Zhang, Q, Haridass, I, Mohammed, Y & Roberts, MS 2017, 'Non-formulation parameters that affect penetrant-skin-vehicle interactions and percutaneous absorption', Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin: Methodology and General Considerations, Springer, Germany, ch. 4, pp. 45-75. 1
2017	Leite-Silva, V, Grice, J, Mohammed, Y, Moghimi, H & Roberts, M 2017, 'The influence of emollients on dermal and transdermal drug delivery', Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin: Methodology and General Considerations, Springer, Germany, ch. 5, pp. 77-93.
2017	Liang, X, Wang, H, Liu, X, Grice, J, Xu, ZP & Roberts, M 2017, 'Related topic: safety evaluation of nanomaterials', in K Sugibayashi (ed.), Skin permeation and disposition of therapeutic and cosmeceutical compounds, Springer, Japan, ch. 28, pp. 313-322.
2017	Liu, X, Wang, H, Liang, X & Roberts, M 2017, 'Hepatic metabolism in liver health and disease', Liver pathophysiology: therapies and antioxidants, Academic Press, UK, ch. 30, pp. 391-400.
2017	Mohammed, Y, Moghimi, H, Yousef, SA, Chandrasekaran, NC, Bibi, CR, Sukumar, SC, Grice, J, Sakran, W & Roberts, M 2017, 'Efficacy, safety and targets in topical and transdermal active and excipient delivery', Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin: Methodology and General Considerations, Springer, Germany, ch. 23, pp. 369-391.
2017	Pastore, MN & Roberts, MS 2017, 'Selection of topically applied chemical candidates: Transdermal drug delivery systems', in K Sugibayashi (ed.), Skin permeation and disposition of therapeutic and cosmeceutical compounds, Springer Japan KK, Japan, ch. 21, pp. 251-262.
2016	Benson, H, Mohammed, Y, Grice, J & Roberts, M 2016, 'Formulation effects on topical nanoparticle penetration', in MR Hamblin, P Avci & TW Prow (eds), Nanoscience in dermatology, Academic Press, UK, ch. 9, pp. 115-126. 2
2016	Ryan, E, Grice, JE & Roberts, MS 2016, 'Nanotechnology for topical and transdermal drug delivery and targeting', in JL Arias (ed.), Nanotechnology and drug delivery, volume two: nano-engineering strategies and nanomedicines against severe diseases, CRC Press, US, ch. 4, pp. 75-101.
2016	Thorling, CA, Holmes, A, Studier, H, Liu, D, Liang, X & Roberts, MS 2016, 'Multiphoton and fluorescence lifetime imaging microscopy in studying nanoparticle pharmacokinetics in skin and liver', in SG Stanciu (ed.), Micro and nanotechnologies for biotechnology, InTech, Croatia, ch. 5, pp. 107-123. Open access
2015	Kuswahyuning, R, Grice, JE, Moghimi, HR & Roberts, MS 2015, 'Formulation effects in percutaneous absorption', in N Dragicevic & HI Maibach (eds), Percutaneous penetration enhancers chemical methods in penetration enhancement : drug manipulation strategies and vehicle effects, Springer, Berlin, ch. 9, pp. 109-134. 1
2015	Sanchez, WY, Pastore, M, Haridass, IN, König, K, Becker, W & Roberts, MS 2015, 'Fluorescence lifetime imaging of the skin', in W Becker (ed.), Advanced time-correlated single photon counting applications, Springer, Switzerland, ch. 15, pp. 457-508. 7
2014	Anissimov, YG & Roberts, MS 2014, 'Mathematical models for topical and transdermal drug products', in Shah, Vinod P, Maibach, Howard I & Jenner, J (eds), Topical drug bioavailability, bioequivalence, and penetration, 2ed, Springer, United States, ch.15, pp. 249-298.
2014	Sanchez, WY, Song, Z, Becker, W, Koenig, K & Roberts, MS 2014, 'Fluorescence lifetime imaging for diagnostic and therapeutic intravital microscopy', in R Weigert (ed.), Advances in intravital microscopy, Springer, US, ch. 16, pp. 371-418. 1
2011	Geusens, B, Mollet, I, Anderson, CD, Terras, S, Roberts, MS & Lambert, J 2011, 'Changes in skin immunity with age and disease', in N Dayan & PW Wertz (eds), Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products, Wiley-Blackwell, US, ch. 11, pp. 217-258.
2011	Grice, JE, Prow, TW, Kendall, MA & Roberts, MS 2011, 'Electrical and physical methods of skin penetration enhancement', in HAE Benson & AC Watkinson (eds), Topical and transdermal drug delivery: principles and practice, Wiley, US, ch. 3, pp. 43-66. 9
2011	Wu, Y-T, Anissimov, YG & Roberts, MS 2011, 'Introduction to dermatokinetics', in SN Murthy (ed.), Dermatokinetics of therapeutic agents, CRC Press, US, ch. 1, pp. 1-24.
2008	Dancik, Y, Jepps, O & Roberts, MS 2008, 'Beyond stratum corneum', in MS Roberts & KA Walters, Dermal Absorption and Toxicity Assessment, 2, Informa Healthcare, New York, pp. 209-250.
2008	Dancik, Y, Jepps, O & Roberts, MS 2008, 'Physiologically based pharmacokinetics and pharmacodynamics of skin', in MS Roberts & KA Walters, Dermal absorption and toxicity assessment, Second Edition, 2, Informa Healthcare, New York, pp. 179-207.
2008	Roberts, MS & Walters, K 2008, 'Human skin morphology and dermal absorption', in Robert MS Walkers K.A, Dermal absorption and toxicity assessment, Second Edition, 2, Informa Healthcare, New York, pp. 1-15.
2008	Roberts, MS, Gierden, A, Riviere, J & Monteriro-Riviere, N 2008, 'Solvent and vehicle effects on the skin', in MA Robert, KA Walters, Dermal absorption and toxicity assessment, Second Edition, 2, Informa Healthcare, USA, pp. 433-447.

Journal Articles

Year	Output
2019	Abd, E, Benson, HA, Mohammed, YH, Roberts, MS & Grice, JE 2019, 'Permeation mechanism of caffeine and naproxen through in vitro human epidermis: effect of vehicles and penetration enhancers', Skin Pharmacology and Physiology, vol. 32, no. 3, pp. 132-141. 1
2019	Benson, HA, Grice, JE, Mohammed, Y, Namjoshi, S & Roberts, MS 2019, 'Topical and transdermal drug delivery: from simple potions to smart technologies', Current Drug Delivery, vol. 16, no. 5, pp. 444-460.
2019	Haridass, IN, Wei, JC, Mohammed, YH, Crichton, ML, Anderson, CD, Henricson, J, Sanchez, WY, Meliga, SC, Grice, JE, Benson, HA, Kendall, MA & Roberts, MS 2019, 'Cellular metabolism and pore lifetime of human skin following microprojection array mediation', Journal of Controlled Release, vol. 306, pp. 59-68.
2019	Nastiti, C, Mohammed, Y, Telaprolu, K, Liang, X, Grice, J, Roberts, M & Benson, H 2019, 'Evaluation of quantum dot skin penetration in porcine skin: effect of age and anatomical site of topical application', Skin Pharmacology and Physiology, in press.
2019	Sandiford, L, Holmes, AM, Mangion, SE, Mohammed, YH, Zvyagin, A V & Roberts, MS 2019, 'Optical characterization of zinc pyrithione', Photochemistry and Photobiology, online, pp. 1-9. 7
2019	Wang, H, Lu, H, Yang, H, Zhang, X, Thompson, EW, Roberts, MS, Hu, Z, Liang, X & Li, X 2019, 'Impact of Age on Risk of Lymph Node Positivity in Patients with Colon Cancer', Journal Of Cancer, vol. 10, no. 9, pp. 2102-2108. Open access
2018	Abd, E, Benson, H, Roberts, M & Grice, J 2018, 'Follicular penetration of caffeine from topically applied nanoemulsion formulations containing penetration enhancers: in vitro human skin studies', Skin Pharmacology and Physiology, vol. 31, pp. 252-260. 4 4
2018	Abd, E, Benson, HA, Roberts, MS & Grice, JE 2018, 'Minoxidil skin delivery from nanoemulsion formulations containing eucalyptol or oleic acid: enhanced diffusivity and follicular targeting', Pharmaceutics, vol. 10, no.1, article no.19, pp. 1-12. Open access 7 6 1
2018	Abraham, J, Sinollareddy, M, Roberts, MS, Williams, P, Peake, SL, Lipman, J & Roberts, JA 2018, 'Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically patients with sepsis', International Journal of Antimicrobial Agents, in press, pp. 1-25.
2018	Alahakoon, C, Dassanayake, TL, Gawarammana, IB, Sedgwick, EM, Weerasinghe, VS, Abdalla, A, Roberts, MS & Buckley, NA 2018, 'Prediction of organophosphorus insecticide-induced intermediate syndrome with stimulated concentric needle single fibre electromyography', PLoS One, vol. 13, no. 9, pp. 1-19. Open access
2018	Amarah, A, Petlin, D, Grice, J, Hadgraft, J, Roberts, M & Anissimov, Y 2018, 'Compartmental modeling of skin transport', European Journal of Pharmaceutics and Biopharmaceutics, vol. 130, pp. 336-344.
2018	Andréo-Filho, N, Bim, AVK, Kaneko, TM, Kitice, NA, Haridass, IN, Abd, E, Santos Lopes, P, Thakur, SS, Parekh, HS, Roberts, M, Grice, JE, Benson, HA & Leite-Silva, VR 2018, 'Development and evaluation of lipid nanoparticles containing natural botanical oil for sun protection: characterization and in vitro and in vivo human skin permeation and toxicity', Skin Pharmacology and Physiology, vol. 31, no. 1, pp. 1-9. 3 2 1
2018	Chiew, AL, Page, CB, Clancy, D, Mostafa, A, Roberts, MS & Isbister, GK 2018, '2-Methyl-4-chlorophenoxyacetic acid (MCPA) and bromoxynil herbicide ingestion', Clinical Toxicology, v. 56, no. 5, pp. 377-380. 1 1 3
2018	Chiew, AL, Wright, DF, Dobos, NM, McArdle, K, Mostafa, AA, Newth, A, Roberts, MS & Isbister, GK 2018, ''Massive' metformin overdose', British Journal of Clinical Pharmacology, online, pp. 1-5. Open access 4 3 2
2018	Holmes, AM, Kempson, I, Turnbull, T, Paterson, D & Roberts, MS 2018, 'Imaging the penetration and distribution of zinc and zinc species after topical application of zinc pyrithione to human skin', Toxicology and Applied Pharmacology, vol. 343, pp. 40-47. 2 2
2018	Jin, W, Liang, X, Brooks, A, Futrega, K, Liu, X, Doran, MR, Simpson, MJ, Roberts, MS & Wang, H 2018, 'Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice', PEERJ, vol. 2018, no. 12, article no. e6072, pp. 1-17. Open access 1 12
2018	Junqueira Garcia, MT, de Vasconcellos, FLL, Raffier, CP, Roberts, MS, Grice, JE, Benson, HAE & Leite-Silva, VR 2018, 'Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems', Current Topics in Medicinal Chemistry, vol. 18, no. 4, pp. 287-299. 1
2018	Khan, MS & Roberts, MS 2018, 'Challenges and innovations of drug delivery in older age', Advanced Drug Delivery Reviews, vol.135, pp. 3-38. 3 3
2018	Le, T, Gong, Y, Wang, G, Davies, NM, Lillico, R, Lakowski, T, Roberts, MS & Burczynski, FJ 2018, 'The antioxidant activity of recombinant rat hepatic fatty acid binding protein t94a variant', Journal of Pharmacy and Pharmaceutical Sciences, vol. 21, no 1s, pp. 309s-324s. Open access
2018	Mohammed, YH, Holmes, A, Haridass, IN, Sanchez, WY, Studier, H, Grice, JE, Benson, HA & Roberts, MS 2018, 'Support for the safe use of zinc oxide nanoparticle sunscreens: lack of skin penetration or cellular toxicity after repeated application in volunteers', Journal of Investigative Dermatology, in press. 3 3 127
2018	Morley, KC, Baillie, A, Fraser, I, Furneaux-Bate, A, Dore, G, Roberts, M, Abdalla, A, Nghi, P & Haber, PS 2018, 'Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial', British Journal of Psychiatry, vol. 212, no. 6, pp. 362-369. 16 15 28
2018	Rzhevskiy, AS, Telaprolu, K, Mohammed, YH, Grice, JE, Roberts, MS & Anissimov, YG 2018, 'Using a simple equation to predict the microporation-enhanced transdermal drug flux', European Journal of Pharmaceutics and Biopharmaceutics, vol. 127, pp. 12-18. 1 1
2018	Sinnollareddy, MG, Roberts, MS, Lipman, J, Peake, SL & Roberts, JA 2018, 'Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration', Journal of Antimicrobial Chemotherapy, vol. 73, no. 6, pp. 147-1650. 3 3
2018	Vieira, CO, Grice, JE, Roberts, MS, Haridass, IN, Duque, MD, Lopes, PS, Leite-Silva, VR & Martins, TS 2018, 'ZnO:SBA-15 nanocomposites for potential use in sunscreen: preparation, properties, human skin penetration and toxicity', Skin Pharmacology and Physiology, vol. 32, no. 1, pp. 32-42. 1 1
2018	Wang, H, Li, X, Tse, BWC, Yang, H, Thorling, CA, Liu, Y, Touraud, M, Chouane, JB, Liu, X, Roberts, MS & Liang, X 2018, 'Indocyanine green-incorporating nanoparticles for cancer theranostics', Theranostics, vol. 8, no. 5, pp. 1227-1242. Open access 23 25
2018	Wang, H, Yang, H, Xu, ZP, Liu, X, Roberts, MS & Liang, X 2018, 'Anionic long-circulating quantum dots for long-term intravital vascular imaging', Pharmaceutics, vol. 10, no. 4, article no. 244, pp. 1-8. Open access 1 1
2018	Warren, SC, Nobis, M, Magenau, A, Mohammed, YH, Herrmann, D, Moran, I, Vennin, C, Conway, JR, Melenec, P, Cox, TR, Wang, Y, Morton, JP, Welch, HC, Strathdee, D, Anderson, K I, Phan, TG, Roberts, MS & Timpson, P 2018, 'Removing physiological motion from intravital and clinical functional imaging data', eLife, vol. 7, pp. 1-37. Open access 4 4 13
2018	Wei, JC, Haridass, IN, Crichton, ML, Mohammed, YH, Meliga, SC, Sanchez, WY, Grice, JE, Benson, HA, Roberts, MS & Kendall, MA 2018, 'Space-and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays', Scientific Reports. Open access 3 3 11
2018	Yamada, M, Tayeb, H, Wang, H, Dang, N, Mohammed, YH, Osseiran, S, Belt, PJ, Roberts, M, Evans, CL, Sainsbury, F & Prow, TW 2018, 'Using elongated microparticles to enhance tailorable nanoemulsion delivery in excised human skin and volunteers', Journal of Controlled Release, vol. 288, pp. 264-276. Open access 1 1 4
2017	Berling, I, Mostafa, A, Grice, JE, Roberts, MS & Isbister, GK 2017, 'Warfarin poisoning with delayed rebound toxicity', Journal of Emergency Medicine, vol. 52, no. 2, pp. 194-196. 9
2017	Brooks, A, Futrega, K, Liang, X, Hu, X, Liu, X, Crawford, DH, Doran, MR, Roberts, MS & Wang, H 2017, 'Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells', Stem Cells Translational Medicine, vol. 7, no. 1, pp. 78-86. Open access 8 6 1
2017	Cardon-Dunbar, A, Robertson, T, Roberts, MS & Isbister, GK 2017, 'Pramipexole overdose associated with visual hallucinations, agitation and myoclonus', Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology, 13, no. 4, pp. 343-346. 1
2017	Chan, BS, Becker, T, Chiew, AL, Abdalla, AM, Robertson, TA, Liu, X, Roberts, MS & Buckley, NA 2017, 'Vasoplegic shock treated with methylene blue complicated by severe serotonin syndrome', Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology, online, pp. 1-4. 2 2 1
2017	Gilbert, A V, Patel, BK, Roberts, MS, Williams, DB, Crofton, JH, Morris, NM, Wallace, J & Gilbert, AL 2017, 'An audit of medicines information quality in electronically generated discharge summaries: evidence to meet the Australian national safety and quality health service standards', Journal of Pharmacy Practice and Research, vol. 47, no. 5, pp. 355-364.
2017	Jayaweera, D, Islam, S, Gunja, N, Cowie, C, Broska, J, Poojara, L, Roberts, MS & Isbister, GK 2017, 'Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations', Clinical Toxicology, vol. 55, no. 2, pp. 147-150. 5 3 3
2017	Nastiti, CM, Ponto, T, Abd, E, Grice, JE, Benson, HA & Roberts, MS 2017, 'Topical nano and microemulsions for skin delivery', Pharmaceutics, vol. 9, no. 4, article no. 37, pp. 1-25. Open access 23 23
2017	Roberts, M, Mohammed, Y, Pastore, M, Namjoshi, S, Yousef, S, Alinaghi, A, Haridass, I, Abd, E, Leite-Silva, V, Benson, H & Grice, J 2017, 'Topical and cutaneous delivery using nanosystems', Journal of Controlled Release, vol. 247, pp. 86-105. 43 41 1
2017	Sime, FB, Hahn, U, Warner, MS, Tiong, IS, Roberts, MS, Lipman, J, Peake, SL & Roberts, JA 2017, 'Using population pharmacokinetic modeling and Monte Carlo simulations to determine whether standard doses of piperacillin in piperacillin-tazobactam regimens are adequate for the management of febrile neutropenia', Antimicrobial Agents and Chemotherapy, vol. 61, no. 11, article no. e00311-17, pp. 1-7. 4 3 19
2017	Wang, H, Thorling, CA, Xu, ZP, Crawford, DH, Liang, X, Liu, X & Roberts, MS 2017, 'Visualization and modeling of the In vivo distribution of mesenchymal stem cells', Current Protocols in Stem Cell Biology, vol. 43, pp. 2B.8.1-2B.8.17. 2
2017	Wang, H, Zhang, R, Bridle, KR, Jayachandran, A, Thomas, JA, Zhang, W, Yuan, J, Xu, ZP, Crawford, DH, Liang, X, Liu, X & Roberts, MS 2017, 'Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury', Scientific Reports, vol. 7, article no. 45374, pp. 1-11. Open access 9 6
2017	Yousef, S, Mohammed, Y, Namjoshi, S, Grice, J, Sakran, W & Roberts, M 2017, 'Mechanistic evaluation of hydration effects on the human epidermal permeation of salicylate esters', AAPS Journal, vol. 19, no. 1, pp. 180-190. 5 4 1
2016	Abd, E, Namjoshi, S, Mohammed, YH, Roberts, MS & Grice, JE 2016, 'Synergistic skin penetration enhancer and nanoemulsion formulations promote the human epidermal permeation of caffeine and naproxen', Journal of Pharmaceutical Sciences, vol. 105, no. 1, pp. 212-220. 13 14 7
2016	Abd, E, Yousef, SA, Pastore, MN, Telaprolu, K, Mohammed, Y, Namjoshi, S, Grice, JE & Roberts, M 2016, 'Skin models for the testing of transdermal drugs', Clinical Pharmacology: Advances and Applications, vol. 8, pp. 163-176. Open access 58 47 1
2016	Alobaid, AS, Brinkmann, A, Frey, OR, Roehr, AC, Luque, S, Grau, S, Wong, G, Abdul-Aziz, M-H, Roberts, MS, Lipman, J & Roberts, JA 2016, 'What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?', Journal of Antimicrobial Chemotherapy, vol. 71, no. 3, pp. 696-702. 13 12 5
2016	Alobaid, AS, Wallis, SC, Jarrett, P, Starr, T, Stuart, J, Lassig-Smith, M, Mejia, JLO, Roberts, MS, Sinnollareddy, MG, Roger, C, Lipman, J & Roberts, JA 2016, 'Effect of obesity on the population pharmacokinetics of fluconazole in critically Ill patients', Antimicrobial Agents and Chemotherapy, vol. 60, no. 11, pp. 6550-6557. Open access 9 9 12
2016	Chandrasekaran, NC, Sanchez, WY, Mohammed, YH, Grice, JE, Roberts, MS & Barnard, RT 2016, 'Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles', Magnesium Research, vol. 29, no. 2, pp. 35-42. Open access 3 5 12
2016	Holmes, AM, Lim, J, Studier, H & Roberts, MS 2016, 'Varying the morphology of silver nanoparticles results in differential toxicity against micro-organisms, HaCaT keratinocytes and affects skin deposition', Nanotoxicology, vol. 10, no. 10, pp. 1503-1514. 13 12
2016	Holmes, AM, Song, Z, Moghimi, HR & Roberts, M 2016, 'Relative penetration of zinc oxide and zinc ions into human skin after application of different zinc oxide formulations', ACS Nano, vol. 10, no. 2, pp. 1810-1819. 38 35 6
2016	Isbister, GK, Ang, K, Gorman, K, Cooper, J, Mostafa, A & Roberts, MS 2016, 'Zero-order metoprolol pharmacokinetics after therapeutic doses: severe toxicity and cardiogenic shock', Clinical Toxicology, vol. 54, no. 9, pp. 881-885. 2 2 3
2016	Lamb, T, Selvarajah, LR, Mohamed, F, Jayamanne, S, Gawarammana, I, Mostafa, A, Buckley, NA, Roberts, MS & Eddleston, M 2016, 'High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka: implications for global suicide prevention', Clinical Toxicology, vol. 54, no. 8, pp. 624-631. Open access 5 5 1
2016	Leite-Silva, V, Sanchez, W, Studier, H, Liu, D, Mohammed, Y, Holmes, A, Ryan, E, Haridass, I, Chandrasekaran, N, Becker, W, Grice, J, Benson, H & Roberts, M 2016, 'Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment', European Journal of Pharmaceutics and Biopharmaceutics, vol. 104, pp.140-147. 18 17 4
2016	Leite-Silva, VR, Liu, DC, Sanchez, WY, Studier, H, Mohammed, YH, Holmes, A, Becker, W, Grice, JE, Benson, HA & Roberts, MS 2016, 'Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles', Nanomedicine, vol. 11, no. 10, pp. 1193-1205. 18 17
2016	Liang, X, Wang, H, Grice, JE, Li, L, Liu, X, Xu, ZP & Roberts, MS 2016, 'Physiologically based pharmacokinetic model for long-circulating inorganic nanoparticles', Nano Letters: A Journal Dedicated to Nanoscience and Nanotechnology, vol. 16, no. 2, pp. 939-945. 15 14
2016	Liang, X, Wang, H, Zhu, Y, Zhang, R, Cogger, VC, Liu, X, Xu, ZP, Grice, JE & Roberts, MS 2016, 'Short-and long-term tracking of anionic ultrasmall nanoparticles in kidney', ACS Nano, vol. 10, no. 1, pp. 387-395. 28 25 5
2016	Page, CB, Mostafa, A, Saiao, A, Grice, JE, Roberts, MS & Isbister, GK 2016, 'Cardiovascular toxicity with levetiracetam overdose', Clinical Toxicology, vol. 54, no. 2, pp. 152-154. 4 3 3
2016	Pastore, ML, Studier, H, Bonder, CS & Roberts, M 2016, 'Non-invasive metabolic imaging of melanoma progression', Experimental Dermatology, vol. 26, no. 7, pp. 607-614. 6 3 1
2016	Roberts, JA, Choi, GY, Joynt, GM, Paul, SK, Deans, R, Peake, S, Cole, L, Stephens, D, Bellomo, R, Turnidge, J, Wallis, SC, Roberts, MS, Roberts, DM, Lassig-Smith, M, Starr, T & Lipman, J 2016, 'SaMpling antibiotics in renal replacement therapy (SMARRT): an observational pharmacokinetic study in critically ill patients', BMC Infectious Diseases, vol. 16, no. 103, pp. 1-8. Open access 7 6 5
2016	Sinnollareddy, MG, Roberts, MS, Lipman, J, Lassig-Smith, M, Starr, T, Robertson, T, Peake, SL & Roberts, JA 2016, 'In vivo microdialysis to determine subcutaneous interstitial fluid penetration and pharmacokinetics of fluconazole in intensive care unit patients with sepsis', Antimicrobial Agents and Chemotherapy, vol. 60, no. 2, pp. 827-832. Open access 6 6 12
2016	Wang, H, Liang, X, Gravot, G, Thorling, CA, Crawford, DH, Xu, ZP, Liu, X & Roberts, MS 2016, 'Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy', Journal of Biophotonics, online, pp. 1-15. 9 7 3
2016	Wang, H, Liang, X, Xu, ZP, Crawford, DH, Liu, X & Roberts, M 2016, 'A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells', Scientific Reports, vol. 6, article no. 22293, pp. 1-12. Open access 10 9
2016	Wong, L, Wong, A, Robertson, T, Burns, K, Roberts, M & Isbister, G 2016, 'Severe hypertension and bradycardia secondary to midodrine overdose', Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology, vol. 13, no. 1, pp. 88-90. 1 1 3
2016	Yousef, S, Liu, X, Mostafa, A, Mohammed, Y, Grice, JE, Anissimov, YG, Sakran, W & Roberts, MS 2016, 'Estimating maximal In vitro skin permeation flux from studies using non-sink receptor phase conditions', Pharmaceutical Research, vol. 33, no. 9, pp. 2180-2194. 4 4 7
2015	Abd, E, Roberts, M & Grice, J 2015, 'A comparison of the penetration and permeation of caffeine into and through human epidermis after application in various vesicle formulations', Skin Pharmacology and Physiology, vol. 29, no. 1, pp. 24-30. 8 7
2015	Arab, H-A, Walker, N I, Cheung, K, Hickman, PE, Potter, JM, Kadkhodaee, M & Roberts, MS 2015, 'Free radical scavengers improve liver function but not morphological changes induced by reperfusion injury', Journal of Investigative Surgery, vol. 28, no. 2, pp. 77-85. 1
2015	Berling, I, Buckley, NA, Mostafa, A, Downes, MA, Grice, J, Medley, G, Roberts, MS & Isbister, GK 2015, '2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death', Clinical Toxicology, vol. 53, no. 5, pp. 486-488. 4 3 4
2015	Downes, MA, Berling, IL, Mostafa, A, Grice, J, Roberts, MS & Isbister, GK 2015, 'Acute behavioural disturbance associated with phenibut purchased via an internet supplier', Clinical Toxicology, vol. 53, no. 7, pp. 636-638. 8 8 21
2015	Gordon, S, Daneshian, M, Bouwstra, J, Caloni, F, Roberts, MS & Lehr, CM and 23 other authors 2015, 'Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology', ALTEX-Alternatives to Animal Experimentation, vol. 32, no. 4, pp. 327-378. Open access 43 37
2015	Liang, XL, Grice, JE, Zhu, Y, Liu, D, Sanchez, WY, Li, Z, Crawford, DH, Le Couteur, DG, Cogger, VC, Liu, X, Xu, ZP & Roberts, MS 2015, 'Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sunusoidal liver cells', Small, vol. 11, no. 14, pp. 1711-1720. 23 25
2015	Mahmood, AH, Liu, X, Grice, JE, Medley, GA & Roberts, MS 2015, 'Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection', International Journal of Pharmaceutics, vol. 481, no. 1-2, pp. 71-78. 3 3
2015	Michael, AP, Mostafa, A, Cooper, J, Grice, J, Roberts, MS & Isbister, GK 2015, 'The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose', Clinical Toxicology, vol. 53, no. 7, pp. 633-635. 2 1
2015	Pastore, MN, Kalia, YN, Horstmann, M & Roberts, MS 2015, 'Transdermal patches: history, development and pharmacology', British Journal of Pharmacology, vol. 172, no. 9, pp. 2179-2209. Open access 86 76 7
2015	Reeve, E, Andrews, JM, Wiese, MD, Hendrix, I, Roberts, MS & Shakib, S 2015, 'Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors', Annals of Pharmacotherapy, vol. 49, no. 1, pp. 29-38. 40 29 8
2015	Roberts, DM, Xin, L, Roberts, J, Nair, P, Cole, L, Roberts, M, Lipman, J & Bellomo, R 2015, 'A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics', Critical Care, vol. 19, pp. 1-9. Open access 41 41 6
2015	Roberts, JA, Udy, AA, Jarrett, P, Wallis, SC, Hope, WW, Sharma, R, Kirkpatrick, CM, Kruger, PS, Roberts, MS & Lipman, J 2015, 'Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-traumacritically ill patients', Journal of Antimicrobial Chemotherapy, vol. 70, no. 5, pp. 1495-1502. Open access 26 24
2015	Sime, FB, Roberts, M, Tiong, IS, Gardner, J, Lehman, S, Peake, S, Hahn, U, Warner, M & Roberts, J 2015, 'Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies', Antimicrobial Agents and Chemotherapy, v 59, no. 9, pp.5463-5469. Open access 9 8
2015	Sime, FB, Roberts, M, Tiong, IS, Gardner, JH, Lehman, S, Peake, SL, Hahn, U, Warner, MS & Roberts, JA 2015, 'Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial', Journal of Antimicrobial Chemotherapy, vol. 70, no. 8, pp. 2369-2375. Open access 22 15 8
2015	Sime, FBR, Roberts, MS & Roberts, J 2015, 'Optimization of dosing regimens and dosing in special populations', Clinical Microbiology and Infection, vol. 21, no. 10, pp. 886-893. Open access 26 23 7
2015	Sinnollareddy, MG, Roberts, M, Lipman, J, Peake, SL & Roberts, J 2015, 'Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: Use of microdialysis', International Journal of Antimicrobial Agents, vol. 46, no. 1, pp. 121-124. 4 4
2015	Sinnollareddy, MG, Roberts, MS, Lipman, J, Robertson, TA, Peake, SL & Roberts, JA 2015, 'Pharmacokinetics of fluconazole in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration', International Journal of Antimicrobial Agents, vol. 45, no. 2, pp. 192-195. 6 6 1
2015	Skinner, K, Saiao, A, Mostafa, A, Soderstrom, J, Medley, G, Roberts, MS & Isbister, GK 2015, 'Isoniazid poisoning: pharmacokinetics and effect of hemodialysis in a massive ingestion', Hemodialysis International, vol. 19, no. 4, pp. E37-E40. 6 6 7
2015	Thorling, CA, Jin, L, Weiss, M, Crawford, D, Liu, X, Burczynski, FJ, Liu, D, Wang, H & Roberts, MS 2015, 'Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition', Drug Metabolism and Disposition, vol. 43, no. 1, pp. 154-162. Open access 11 9 1
2015	Udy, AA, Lipman, J, Jarrett, P, Klein, K, Wallis, SC, Patel, K, Kirkpatrick, CM, Kruger, PS, Paterson, DL, Roberts, MS & Roberts, JA 2015, 'Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?', Critical Care, vol. 19, no. 1, article no. 28, pp. 1-9. Open access 59 52 16
2015	Wang, H, Liang, X, Mohammed, YH, Thomas, JA, Bridle, KR, Thorling, CA, Grice, JE, Xu, ZP, Liu, X, Crawford, DHG & Roberts, MS 2015, 'Real-time histology in liver disease usingmultiphoton microscopy with fluorescencelifetime imaging', Biomedical Optics Express, vol. 9, no. 3, pp. 780-792. 18 16 1
2015	Wang, H, Thorling, CA, Liang, X, Bridle, KR, Grice, JE, Zhu, Y, Crawford, DHG, Xu, ZP, Liu, X & Roberts, MS 2015, 'Diagnostic imaging and therapeutic application of nanoparticles targeting the liver', Journal of Materials Chemistry B, vol. 3, pp. 939-958. 33 32
2014	Chandrasekaran, NC, Weir, C, Alfraji, S, Grice, J, Roberts, MS & Barnard, RT 2014, 'Effects of magnesium deficiency-more than skin deep', Experimental Biology and Medicine, vol. 239, no. 10, pp. 1280-1291. 8 9 5
2014	Krishnan, G, Roberts, M, Grice, J, Anissimov, Y, Moghimi, H & Benson, H 2014, 'Iontophoretic skin permeation of peptides : an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters', Drug Delivery and Translational Research, vol. 4, no. 3, pp. 222-232. 8 7
2014	Kuswahyuning, R & Roberts, MS 2014, 'Concentration dependency in nicotine skin penetration flux from aqueous solutions reflects vehicle induced changes in nicotine stratum corneum retention', Pharmaceutical Research, vol. 31, no. 6, pp. 1501-1511. 9 6
2014	Liu, X, Kruger, P, Maibach, H, Colditz, PB & Roberts, MS 2014, 'Using skin for drug delivery and diagnosis in the critically ill', Advanced Drug Delivery Reviews, vol. 77, pp. 40-49. 9 9
2014	McNeilly, CL, Crichton, ML, Primiero, CA, Frazer, IH, Roberts, MS & Kendall, MA 2014, 'Microprojection arrays to immunise at mucosal surfaces', Journal of Controlled Release, vol. 196, pp. 252-260. 10 10 1
2014	Mohammed, YH, Yamada, M, Lin, LL, Grice, JE, Roberts, MS, Raphael, AP, Benson, HA & Prow, TW 2014, 'Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin', PLoS One, vol. 9, no. 7, article no. e101956, pp. 1-9. Open access 30 28
2014	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2014, 'Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process', British Journal of Clinical Pharmacology, vol. 78, no. 4, pp. 738-747. Open access 102 95 47
2014	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2014, 'The benefits and harms of deprescribing', Medical Journal of Australia, vol. 201, no. 7, pp. 386-389. 43 27 7
2014	Sime, FB, Roberts, MS, Roberts, JA & Robertson, TA 2014, 'Simultaneous determination of seven β-lactam antibiotics in human plasma for therapeutic drug monitoring and pharmacokinetic studies', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 960, pp. 134-144. 36 35 1
2014	Sime, FB, Roberts, MS, Warner, MS, Hahn, U, Robertson, TA, Yeend, S, Phay, A, Lehman, S, Lipman, J, Peake, SL & Roberts, JA 2014, 'Altered pharmacokinetics of piperacillin in febrile neutropenic patients with haematological malignancy', Antimicrobial Agents and Chemotherapy, vol. 58, no. 6, pp. 3533-3537. Open access 22 20 3
2014	Thorling, CA, Crawford, D, Burczynski, FJ, Liu, X, Liau, I & Roberts, MS 2014, 'Multiphoton microscopy in defining liver function', Journal of Biomedical Optics, vol. 19, no. 9, article no. 090901 pp. 090901.1-090901.11. Open access 18 13
2014	Thorling, CA, Roberts, MS, Liu, X, Fletcher, LM, Crawford, D & Burczynski, FJ 2014, 'Effects of long-term hepatic ischemia-reperfusion injury on the function of P-glycoprotein in vivo in rats', Journal of Pharmacy and Pharmaceutical Sciences, vol. 17 no. 1, pp. 121-135. Open access 5 5
2014	Wong, G, Brinkman, A, Benefield, RJ, Carlier, M, Roberts, MS, Robertson, TA, Sime, FB & Roberts, JA and 13 other authors 2014, 'An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units', Journal of Antimicrobial Chemotherapy, vol. 69, no. 5, article no. dkt523, pp. 1416-1423. 86 76 8
2014	Wunnapuk, K, Gobe, G, Endre, Z, Peake, P, Grice, JE, Roberts, MS, Buckley, NA & Liu, X 2014, 'Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers', Toxicology Letters, vol. 225, no. 1, pp. 192-200. Open access 20 20 8
2014	Wunnapuk, K, Liu, X, Gobe, GC, Endre, ZH, Peake, PW, Grice, JE, Roberts, MS & Buckley, NA 2014, 'Kidney biomarkers in MCPA-induced acute kidney injury in rats : reduced clearance enhances early biomarker performance', Toxicology Letters, vol. 225, no. 3, pp. 467-478. Open access 6 6
2014	Wunnapuk, K, Mohammed, F, Gawarammana, I, Liu, X, Verbeeck, RK, Buckley, NA, Roberts, MS & Musuamba, FT 2014, 'Prediction of paraquat exposure and toxicity in clinically ill poisoned patients : a model based approach', British Journal of Clinical Pharmacology, vol. 78, no. 4, pp. 855-866. Open access 18 14 9
2013	Anissimov, YG, Jepps, OG, Dancik, Y & Roberts, MS 2013, 'Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes', Advanced Drug Delivery Reviews, vol. 65, no. 2, pp. 169-190. 59 53
2013	Arab, H-A, Cheung, K, Hickman, PE, Potter, JM, Walker, N I & Roberts, MS 2013, 'A comparison of hepatic ischemia/hypoxia-reperfusion injury models', Journal of Pharmacological and Toxicological Methods, vol. 68, no. 3, pp. 349-356. 1 1
2013	Dancik, Y, Favre, A, Loy, CJ, Zvyagin, A V & Roberts, MS 2013, 'Use of multiphoton tomography and fluorescence lifetime imaging to investigate skin pigmentation in vivo', Journal of Biomedical Optics, vol. 18, no. 2, article no. 026022, pp. 1-13. Open access 29 20
2013	Jepps, OG, Dancik, Y, Anissimov, YG & Roberts, MS 2013, 'Modeling the human skin barrier - towards a better understanding of dermal absorption', Advanced Drug Delivery Reviews, vol. 65, no. 2, pp. 152-168. 102 91
2013	Krishnan, G, Grice, JE, Roberts, MS, Benson, HA & Prow, TW 2013, 'Enhanced sonophoretic delivery of 5-aminolevulinic acid : preliminary human ex vivo permeation data', Skin Research and Technology, vol. 19, no. 1, pp. e283-e289. 13 12
2013	Kruger, P, Bailey, M, Bellomo, R, Cooper, DJ, Harward, M, Higgins, A, Howe, B, Jones, D, Joyce, C, Kostner, K, McNeil, J, Nichol, A, Roberts, MS, Syres, G & Venkatesh, B 2013, 'A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis', American Journal of Respiratory and Critical Care Medicine, vol. 187, no. 7, pp. 743-750. 122 119 29
2013	Leite-Silva, VR, Le Lamer, M, Sanchez, WY, Liu, DC, Sanchez, WH, Morrow, I, Martin, D, Silva, HD, Prow, TW, Grice, JE & Roberts, MS 2013, 'The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo', European Journal of Pharmaceutics and Biopharmaceutics, vol. 84, no. 2, pp. 297-308. 69 60 1
2013	Liang, XW, Xu, ZP, Grice, JE, Zvyagin, A, Roberts, MS & Liu, X 2013, 'Penetration of nanoparticles into human skin', Current Pharmaceutical Design, vol. 19, no. 35, pp. 6353-6366. 11 10 3
2013	Liu, X, Jin, L, Upham, JW & Roberts, MS 2013, 'The development of models for the evaluation of pulmonary drug disposition', Expert Opinion on Drug Metabolism and Toxicology, vol. 9, no. 4, pp. 487-505. 8 7 1
2013	Mahmood, A, Grice, JE, Roberts, MS & Prow, TW 2013, 'Feasibility of multiphoton microscopy-based quantification of antibiotic uptake into neutrophil granulocytes', Journal of Biomedical Optics, vol. 18, no. 7, pp.1-6. Open access 1
2013	Mutalik, S, Parekh, H, Anissimov, Y, Grice, J & Roberts, MS 2013, 'Iontophoresis-mediated transdermal permeation of peptide dendrimers across human epidermis', Skin Pharmacology and Physiology, vol. 26, no. 3, pp. 127-138. 27 26
2013	Raphael, AP, Sundh, D, Grice, JE, Roberts, MS, Soyer, HP & Prow, TW 2013, 'Zinc oxide nanoparticle removal from wounded human skin', Nanomedicine, vol. 8, no. 11, pp. 1751-1761. 16 13
2013	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2013, 'Development and validation of the patients' attitudes towards deprescribing (PATD) questionnaire', International Journal of Clinical Pharmacy, vol. 35, no. 1, pp. 51-56. 38 35
2013	Reeve, E, To, J, Hendrix, I, Shakib, S, Roberts, MS & Wiese, MD 2013, 'Patient barriers to and enablers of deprescribing: a systematic review', Drugs and Aging, vol. 30, no. 10, pp. 793-807. Open access 150 142 44
2013	Reeve, E, Wiese, MD, Hendrix, I, Roberts, MS & Shakib, S 2013, 'People's attitudes, beliefs, and experiences regarding polypharmacy and willingness to deprescribe', Journal of the American Geriatrics Society, vol. 61, no. 9, pp. 1508-1514. 93 76 15
2013	Roberts, MS 2013, 'Solute-vehicle-skin interactions in percutaneous absorption: the principles and the people', Skin Pharmacology and Physiology, vol. 26, no. 4, pp. 356-370. Open access 9 7
2013	Robertson, TA, Bunel, F & Roberts, MS 2013, 'Fluorescein derivatives in intravital fluorescence imaging', Cells, vol. 2, no. 3, pp. 591-606. Open access 3
2013	Sanchez, W, Obispo, C, Ryan, E, Grice, JE & Roberts, MS 2013, 'Changes in the redox state and endogenous fluorescence of in vivo human skin due to intrinsic and photo-aging, measured by multiphoton tomography with fluorescence lifetime imaging', Journal of Biomedical Optics, vol. 18, no. 6, pp. 1-13. Open access 19 15 1
2013	Song, Z, Anissimov, YG, Zhao, J, Nechaev, A V, Nadort, A, Jin, D, Prow, TW, Roberts, MS & Zvyagin, A V 2013, 'Background free imaging of upconversion nanoparticle distribution in human skin', Journal of Biomedical Optics, vol. 18, no. 6, pp. 1-10. Open access 27 21
2013	Thorling, CA, Liu, X, Burczynski, FJ, Fletcher, LM, Roberts, MS & Sanchez, WY 2013, 'Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury', Journal of Biomedical Optics, vol. 18, no. 10, article no. 101306, pp. 1-11. Open access 16 14
2013	Weiss, M, Liu, X, Thompson, CA & Roberts, MS 2013, 'Functional characterization of hepatic transporters using intravital microscopy', European Journal of Pharmaceutical Sciences, vol. 49, no. 5, pp. 845-849. 7 6
2013	Wunnapuk, K, Liu, X, Peake, P, Gobe, G, Endre, Z, Grice, JE, Roberts, MS & Buckley, NA 2013, 'Renal biomarkers predict nephrotoxicity after paraquat', Toxicology Letters, vol. 222, no. 3, pp. 280-288. 22 19 1
2013	Zhang, Q, Li, P, Liu, D & Roberts, MS 2013, 'Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds', Pharmaceutical Research, vol. 30, no. 1, pp. 32-40. 19 17 1
2012	Anissimov, YG, Zhao, X, Roberts, MS & Zvyagin, A V 2012, 'Fluorescence recovery after photo-bleaching as a method to determine local diffusion coefficient in the stratum corneum', International Journal of Pharmaceutics, vol. 435, no. 1, pp. 93-97. 14 12 3
2012	Dancik, Y, Anissimov, YG, Jepps, OG & Roberts, MS 2012, 'Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application', British Journal of Clinical Pharmacology, vol. 73, no. 4, pp. 564-578. Open access 30 23 1
2012	Gilbert, A, Patel, B, Morrow, M, Williams, D, Roberts, MS & Gilbert, AL 2012, 'Providing community-based health practitioners with timely and accurate discharge medicines information', BMC Health Services Research, vol. 12, article no. 453 pp. 1-7. Open access 3 1
2012	Kaur, S, Roberts, JA & Roberts, MS 2012, 'Evaluation of medication-related problems in medication reviews : a comparative perspective', Annals of Pharmacotherapy, vol. 46, no. 7-8, pp. 972-982. Open access 11 10 2
2012	Leite-Silva, VR, de Almeida, MM, Fradin, A, Grice, JE & Roberts, MS 2012, 'Delivery of drugs applied topically to the skin', Expert Review of Dermatology, vol. 7, no. 4, pp. 383-397. 22
2012	Li, P, Robertson, TA, Zhang, Q, Fletcher, LM, Crawford, DH, Weise, M & Roberts, MS 2012, 'Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage', Pharmaceutical Research, vol. 29, no. 6, pp. 1658-1669. 10 8
2012	Li, P, Weise, M & Roberts, MS 2012, 'Hepatic interaction between quinidine and digoxin: role of inhibition of sinusoidal Na+/K+ ATPase digoxin binding', European Journal of Pharmaceutical Sciences, vol. 47, no. 2, pp. 506-511. 1 1
2012	Liu, DC, Raphael, AP, Sundh, D, Grice, JE, Soyer, H, Roberts, M & Prow, TW 2012, 'The human stratum corneum prevents small gold nanoparticle penetration and their potential toxic metabolic consequences', Journal of Nanomaterials, vol. 2012, article no. 721706, pp. 1-8. Open access 14 15
2012	Liu, X, Kruger, PS, Weise, M & Roberts, MS 2012, 'The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis', British Journal of Clinical Pharmacology, vol. 73, no. 5, pp. 741-749. Open access 7 7 1
2012	Liu, X, Thorling, CA, Jin, L & Roberts, MS 2012, 'Intravital multiphoton imaging of rhodamine 123 in the rat liver after intravenous dosing', IntraVital, vol. 1, no. 1, pp. 54-59. Open access
2012	Mahmood, AH, Medley, GA, Grice, JE, Liu, X & Roberts, MS 2012, 'Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection', Journal of Pharmaceutical and Biomedical Analysis, vol. 62, pp. 220-223. 10 8
2012	Prow, TW, Monteriro-Riviere, NA, Inman, AO, Grice, JE, Chen, X, Zhao, X, Sanchez, WH, Gierden, A, Kendall, MA, Zvyagin, A V, Erdmann, D, Riviere, JE & Roberts, MS 2012, 'Quantum dot penetration into viable human skin', Nanotoxicology, vol. 6, no. 2, pp. 173-185. 64 54
2012	Roberts, DM, Roberts, JA, Roberts, MS, Liu, X, Nair, P, Cole, L, Lipman, J & Bellomo, R 2012, 'Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study', Critical Care Medicine, vol. 40, no. 5, pp. 1523-1528. 117 111 3
2012	Sime, FB, Roberts, MS, Peake, SL, Lipman, J & Roberts, JA 2012, 'Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review', Annals of Intensive Care, vol. 2, article no. 35, pp. 1-11. Open access 82 69 8
2012	Sinnollareddy, MG, Peake, S, Roberts, MS, Lipman, J & Roberts, J 2012, 'Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: A systematic review', International Journal of Antimicrobial Agents, vol. 39, no. 1, pp. 1-10. 25 22 3
2012	Sinnollareddy, MG, Roberts, MS, Lipman, J & Roberts, JA 2012, 'ß-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization : a structured review', Clinical and Experimental Pharmacology and Physiology, vol. 39, no. 6, pp. 489-496. 39 38
2012	Weise, M, Li, P & Roberts, MS 2012, 'Estimation of sinusoidal flow heterogeneity in normal and diseased rat livers from tracer dilution data using a fractal model', Microcirculation, vol. 19, no. 8, pp. 723-728. 3 3
2012	Wiechers, J, Watkinson, A, Cross, S & Roberts, M 2012, 'Predicting skin penetration of actives from complex cosmetic formulations: an evaluation of inter formulation and inter active effects during formulation optimization for transdermal delivery', International Journal of Cosmetic Science, vol. 34, no. 6, pp. 525-535. Open access 13 11 1
2011	Anissimov, YG & Roberts, MS 2011, 'Modelling dermal drug distribution after topical application in human', Pharmaceutical Research, vol. 28, no. 9, pp. 2119-2129. 30 22
2011	Davies, PG, Venkatesh, B, Morgan, TJ, Presneill, JJ, Kruger, PS, Thomas, BJ, Roberts, MS & Mundy, J 2011, 'Plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of Plasma-Lyte 148 with a bicarbonate-balanced solution', Critical Care, vol. 15, no. 1, pp. R21-1-R21-8. Open access 23 24 8
2011	Douglas, A, Altukroni, M, Udy, AA, Roberts, MS, Taraporewalla, K, Jenkins, J, Lipman, J & Roberts, JA 2011, 'The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery', BMC Anesthesiology, vol. 11, article no. 5, pp. 1-5. Open access 6 5 1
2011	Douglas, A, Udy, AA, Wallis, SC, Jarrett, P, Stuart, J, Lassig-Smith, M, Deans, R, Roberts, MS, Taraporewalla, K, Jenkins, J, Medley, G, Lipman, J & Roberts, JA 2011, 'Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery', Antimicrobial Agents and Chemotherapy, vol. 55, no. 11, pp. 5238-5242. Open access 45 42 6
2011	Fanning, KJ, Robertson, TA, Prins, JB & Roberts, MS 2011, 'Changes in antibiotic distribution due to pancreatitis', Antimicrobial Agents and Chemotherapy, vol. 55, no. 6, pp. 3008-3011. 3 1
2011	König, K, Raphael, AP, Lin, L, Grice, JE, Soyer, HP, Breuing, HG, Roberts, MS & Prow, TW 2011, 'Applications of multiphoton tomographs and femtosecond laser nanoprocessing microscopes in drug delivery research', Advanced Drug Delivery Reviews, vol. 63, no. 4-5, pp. 388-404. 77 67 6
2011	Krishnan, G, Roberts, MS, Grice, J, Anissimov, YG & Benson, HA 2011, 'Enhanced transdermal delivery of 5-aminolevulinic acid and a dipeptide by iontophoresis', Biopolymers, vol. 96, no. 2, pp. 166-171. 13 12 3
2011	Kruger, P, Harward, M, Jones, M, Joyce, C, Kostner, K, Roberts, MS & Venkatesh, B 2011, 'Continuation of statin therapy in patients with presumed infection:a randomized controlled trial', American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 6, pp. 774-781. 77 81 2
2011	Labouta, H I, Liu, DC, Lin, LL, Butler, MK, Grice, JE, Raphael, AP, Kraus, T, El-Khordagui, LK, Soyer, HP, Roberts, MS, Schneider, M & Prow, TW 2011, 'Gold nanoparticle penetration and reduced metabolism in human skin by toluene', Pharmaceutical Research, vol. 28, pp. 2931-2944. 49 43
2011	Li, P, Robertson, TA, Thompson, CA, Zhang, Q, Fletcher, LM, Crawford, DH & Roberts, MS 2011, 'Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis', Drug Metabolism and Disposition, vol. 39, no. 4, pp. 571-579. 20 21
2011	Lin, LL, Grice, JE, Butler, MK, Zvyagin, A V, Becker, W, Robertson, TA, Soyer, HP, Roberts, MS & Prow, TW 2011, 'Time-correlated single photon counting for simultaneous monitoring of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin', Pharmaceutical Research, vol. 28, pp. 2920-2930. 74 59
2011	Liu, X, Grice, JE, Lademann, J, Otberg, N, Trauer, S, Patzelt, A & Roberts, MS 2011, 'Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man', British Journal of Clinical Pharmacology, vol. 72, no. 5, pp. 768-774. Open access 53 42 1
2011	Liu, X, Kruger, PS & Roberts, MS 2011, 'How to measure pharmacokinetics in critically ill patients?', Current Pharmaceutical Biotechnology, vol. 12, no. 12, pp. 2037-2043. 6 4
2011	Mitragotri, S, Anissimov, YG, Bunge, AL, Frasch, HF, Guy, RH, Hadgraft, J, Kasting, GB, Lane, ME & Roberts, MS 2011, 'Mathematical models of skin permeability: an overview', International Journal of Pharmaceutics, vol. 418, no. 1, pp. 115-129. 154 133 16
2011	Monajjemzadeh, F, Hassanzadeh, D, Valizadeh, H, Siahi-Shadbad, MR, Mojarrad, JS, Robertson, TA & Roberts, MS 2011, 'Detection of gabapentin-lactose Maillard reaction product (Schiff's Base): Application to solid dosage form preformulation / Part 2', Pharmazeutische Industrie, vol. 73, no. 2, pp. 376-382. 1 1
2011	Monajjemzadeh, F, Hassanzadeh, D, Valizadeh, H, Siahi-Shadbad, MR, Mojarrad, JS, Robertson, TA & Roberts, MS 2011, 'Detection of gabapentin-lactose maillard reaction product (Schiff's base): application to solid dosage form preformulation / Part 1', Pharmazeutische Industrie, vol. 73, no. 1, pp. 174-177. 9 7
2011	Mostafa, A, Medley, G, Roberts, DM, Mohamed, MS, Elshanawani, AA, Roberts, MS & Liu, X 2011, 'Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 879, no. 23, pp. 2234-2238. Open access 14 13
2011	Prow, TW, Grice, JE, Lin, LL, Faye, R, Butler, M, Becker, W, Wurm, EM, Yoong, C, Robertson, TA, Soyer, HP & Roberts, MS 2011, 'Nanoparticles and microparticles for skin drug delivery', Advanced Drug Delivery Reviews, vol. 63, no. 6, pp. 470-491. 442 390 12
2011	Roberts, DM, Wilks, MF, Roberts, MS, Swaminathan, R, Mohamed, F, Dawson, A & Buckley, NA 2011, 'Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning', Toxicology Letters, vol. 202, no. 1, pp. 69-74. Open access 27 28
2011	Roberts, JA, Roberts, MS, Semark, A, Udy, AA, Kirkpatrick, CM, Paterson, DL, Roberts, MJ, Kruger, P & Lipman, J 2011, 'Antibiotic dosing in the 'at risk' critically ill patient : linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients', BMC Anesthesiology, vol. 11, article no. 3, pp. 1-7. Open access 32 30
2011	Roberts, MS, Dancik, Y, Prow, TW, Thompson, CA, Lin, LL, Grice, JE, Robertson, TA, König, K & Becker, W 2011, 'Non-invasive imaging of skin physiology and percutaneous penetration using fluorescence spectral and lifetime imaging with multiphoton and confocal microscopy', European Journal of Pharmaceutics and Biopharmaceutics, vol. 77, no. 3, pp. 469-488. 103 81 3
2011	Roberts, MS, Liu, X, Zou, Y, Siebert, GA, Chang, P, Whitehouse, MW, Fletcher, L & Crawford, DH 2011, 'Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate', American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 300, no. 1, pp. G130-G136. Open access 6 6
2011	Sinnollareddy, M, Peake, SL, Roberts, MS, Playford, EG, Lipman, J & Roberts, JA 2011, 'Pharmacokinetic evaluation of fluconazole in critically ill patients', Expert Opinion on Drug Metabolism and Toxicology, vol. 7, no. 11, pp. 1431-1440. 10 9
2011	Song, Z, Kelf, T, Sanchez, WH, Roberts, MS, Rička, J, Frenz, M & Zvyagin, A 2011, 'Characterization of optical properties of ZnO nanoparticles for quantitative imaging of transdermal transport', Biomedical Optics Express, vol. 2, no. 12, pp. 3321-3333. 33 30 1
2011	Thorling, CA, Dancik, Y, Hupple, CW, Medley, G, Liu, X, Zvyagin, A V, Robertson, TA, Burczynski, FJ & Roberts, MS 2011, 'Multiphoton microscopy and fluorescence lifetime imaging provide a novel method in studying drug distribution and metabolism in the rat liver in vivo', Journal of Biomedical Optics, vol. 16, no. 8, pp. 086013.1-086013.7. Open access 15 13
2011	Thorling, CA, Liu, X, Burczynski, FJ, Fletcher, LM, Gobe, GC & Roberts, MS 2011, 'Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats', Journal of Biomedical Optics, vol. 16, no. 11, article no. 116011, pp. 1-8. Open access 21 18
2011	Wunnapuk, K, Medley, GA, Liu, X, Grice, JE, Jayasinghe, S, Gawarammana, I, Buckley, NA & Roberts, MS 2011, 'Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: application to experimental and clinical toxicological studies', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 879, no. 28, pp. 3047-3052. Open access 23 22
2011	Zhang, Q, Li, P & Roberts, MS 2011, 'Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin', Journal of Controlled Release, vol. 154, no. 1, pp. 50-57. Open access 27 22
2011	Zhou, F, Zhang, J, Li, P, Niu, F, Wu, X, Wang, G & Roberts, MS 2011, 'Toward a new age of cellular pharmacokinetics in drug discovery', Drug Metabolism Reviews, vol. 43, no. 3, pp. 335-345. 29 26
2010	Fernando, GJ, Chen, X, Prow, TW, Crichton, ML, Fairmaid, EJ, Roberts, MS, Frazer, IH, Brown, LE & Kendall, MA 2010, 'Potent immunity of low doses of influenza vaccine by probalistic guided micro-targeted skin delivery in a mouse model', PLoS One, vol. 5, no. 4. Open access 108 94 24
2010	Gawarammana, IB, Roberts, D, Mohamed, f, Roberts, MS, Medley, G, Jayamanne, S & Dawson, A 2010, 'Acute human self-poisoning with bispyribac-containing herbicide Nominee (R): a prospective observational study', Clinical Toxicology, vol. 48, no. 3, pp. 198-202. 2
2010	Geusens, B, Van Gele, M, Braat, S, De Smedt, SC, Stuart, MC, Prow, TW, Sanchez, W, Roberts, MS, Sanders, NN & Lambert, J 2010, 'Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin', Advanced Functional Materials, vol. 20, no. 23, pp. 4077-4090. 52 43
2010	Green, B, Chandler, S, MacDonald, G, Elliott, G & Roberts, MS 2010, 'Quantifying Pain Relief Following Administration of a Novel Formulation of Paracetamol (Acetaminophen)', Journal of Clinical Pharmacology, vol. 50, no. 12, pp. 1406-1413. 4 3
2010	Grice, JE, Ciotti, S, Weiner, N, Lockwood, P, Cross, S & Roberts, MS 2010, 'Relative Uptake of Minoxidil into Appendages and Stratum Corenum and Permeation through Human Skin In Vitro', Journal of Pharmaceutical Sciences, vol. 99, no. 2, pp. 712-718. 39 28 3
2010	Grice, JE, Cross, S, Brownlie, C & Roberts, MS 2010, 'The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration', Journal of Pharmacy and Pharmacology, vol. 62, no. 6, pp. 750-755. 6 4
2010	He, S, Liu, X, Yang, Y, Huang, W, Xu, S, Yang, S, Zhang, X & Roberts, MS 2010, 'Mechanisms of transforming growth factor b1/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts', British Journal of Dermatology, vol. 162, no. 3, pp. 538-546. 69 64 6
2010	Hickman, P, Potter, J, Aroney, C, Koerbin, G, Southcott, E, Wu, AH & Roberts, MS 2010, 'Cardiac troponin may be released by ischemia alone, without necrosis', Clinica Chimica Acta, vol. 411, no. 5-6, pp. 318-323. 140 133 1
2010	Liu, X, Yang, Y, Zhang, X, Xu, S, He, S, Huang, W & Roberts, MS 2010, 'Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-B/Smad in HepG2 cell', Journal of Gastroenterology and Hepatology, vol. 25, no. 2, pp. 420-426. 48 48
2010	Liu, X, Zou, Y, Khlentzos, AM, Yang, Y, Nikolovski, J, Weiss, M & Roberts, MS 2010, 'Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing ', Clinical and Experimental Pharmacology and Physiology, vol. 37, no. 10, pp. 1028-1033.
2010	Park, S, Kim, S, Ropella, G, Roberts, MS & Hunt, A 2010, 'Tracing Multiscale Mechanisms of Drug Disposition in Normal and Diseased Livers', Journal of Pharmacology and Experimental Therapeutics, vol. 334, no. 1, pp. 124-136. 25 22
2010	Popov, AP, Zvyagin, A, Lademann, J, Roberts, M, Sanchez, WY, Priezzhev, AU & Myllyla, R 2010, 'Designing inorganic light-protective skin nanotechnology products', Journal of Biomedical Nanotechnology, vol. 6, no. SI5, pp. 432-451. 46 40
2010	Prow, TW, Chen, X, Prow, NA, Fernando, GJ, Tan, CS, Raphael, AP, Chang, D, Ruutu, MP, Jenkins, DW, Pyke, A, Crichton, ML, Raphaelli, K, Goh, LY, Frazer, IH, Roberts, MS, Gardner, J, Khromykh, AA, Suhrbier, A, Hall, RA & Kendall, MA 2010, 'Nanopatch-targeted skin vaccination against West Nile virus and Chikungunya virus in mice', Small, vol. 6, no. 16, pp. 1776-1784. 103 90
2010	Roberts, J, Kirkpatrick, CM, Roberts, MS, Dalley, A & Lipman, J 2010, 'First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis', International Journal of Antimicrobial Agents, vol. 35, no. 2, pp. 156-163. 108 98
2010	Roberts, J, Ulldemolins, M, Roberts, MS, McWhinney, B, Ungerer, J, Paterson, D & Lipman, J 2010, 'Therapeutic drug monitoring of ß-lactams in critically ill patients: proof of concept', International Journal of Antimicrobial Agents, vol. 36, no. 4, pp. 332-339. 179 175 12
2010	Sanchez, WY, Prow, TW, Sanchez, WH, Grice, JE & Roberts, MS 2010, 'Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy', Journal of Biomedical Optics, vol. 15, no. 4, pp. 046008.1-046008.11. Open access 68 44 3
2010	Weiss, M, Li, P & Roberts, MS 2010, 'An Improved Nonlinear Model Describing the Hepatic Pharmacokinetics of Digoxin: Evidence for Two Functionally Different Uptake Systems and Saturable Binding', Pharmaceutical Research, vol. 27, no. 9, pp. 1999-2007. 13 13
2010	Xia, C, Sun, J, Wang, G, Shang, L, Zhang, X, Zhang, R, Peng, Y, Wang, XJ, Hao, H, Xie, L & Roberts, MS 2010, 'Herb-Drug Interactions: In Vivo and in Vitro Effect of Shenmai Injection, a Herbal Preparation, on the Metabolic Activities of Hepatic Cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in Rats', Planta Medica: Natural Products and Medicinal Plant Research, vol. 76, no. 3, pp. 245-250. 31 22
2010	Zou, Y-H, Liu, X, Khlentzos, AM, Asadian, P, Li, P, Thorling, CA, Robertson, TA, Fletcher, LM, Crawford, DHG & Roberts, MS 2010, 'Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model', Drug Metabolism and Pharmacokinetics, vol. 25, no. 5, pp. 442-449. 1 1
2009	Chen, X, Prow, TW, Crichton, ML, Jenkins, DW, Roberts, MS, Frazer, IH, Fernando, GJ & Kendall, MA 2009, 'Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin', Journal of Controlled Release, vol. 139, no. 3, pp. 212-220. 123 107
2009	Li, P, Wang, G-J, Robertson, TA & Roberts, MS 2009, 'Liver transporters in hepatic drug disposition: an update', Current Drug Metabolism, vol. 10, no. 5, pp. 482-498. 29 26
2009	Liu, X, Wang, JY, Khlentzos, AM, Fontaine, F, Nikolovski, J, Goh, L-A & Roberts, MS 2009, 'Influence of perfusate composition on drug disposition in the in-situ perfused rat lung', International Journal of Pharmaceutics, vol. 382, no. 1-2, pp. 192-197. 5 5
2009	Monajjemzadeh, F, Hassanzadeh, D, Valizadeh, H, Siahi-Shadbad, MR, Mojarrad, JS, Robertson, TA & Roberts, MS 2009, 'Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets', European Journal of Pharmaceutics and Biopharmaceutics, vol. 73, no. 3, pp. 404-413. 51 36
2009	Qian, Z, Grice, JE, Li, P, Jepps, O, Wang, G & Roberts, MS 2009, 'Skin Solubility Determines Maximum Transepidermal Flux for Similar Size Molecules', Pharmaceutical Research, vol. 26, no. 8, pp. 1974-1985. 52 44
2009	Roberts, JA, Roberts, MS, Robertson, TA, Dalley, AJ & Lipman, J 2009, 'Piperacillin penetration into tissue of critically ill patients with sepsis-bolus versus continuous administration?', Critical Care Medicine, vol. 37, no. 3, pp. 926-933. 119 116
2008	Cross, S & Roberts, MS 2008, 'Use of In vitro human skin membranes to model and predict the effect of changing blood flow on the flux and retention of topically applied solutes.', Journal of Pharmaceutical Sciences, vol. 97, no. 8, pp. 3442-3450. 9 7
2008	Cross, S, Russel, M, Southwell, I & Roberts, MS 2008, 'Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro.', European Journal of Pharmaceutics and Biopharmaceutics, vol. 69, no. 1, pp. 214-222. 22 14
2008	Nohynek, G, Dufour, E & Roberts, MS 2008, 'Nanotechnology, cosmetics and the skin: is there a health risk?', Skin Pharmacology and Physiology, vol. 21, no. 3, pp. 136-149. 194 166
2008	Park, S, Ropella, G, Kim, S & Roberts, MS 2008, 'Computational Strategies Unravel and Trace How Liver Disease Changes Hepatic Drug Disposition', Journal of Pharmacology and Experimental Therapeutics, vol. 328, no. 1, pp. 294-305. 21 19
2008	Roberts, J, Roberts, MS, Robertson, TA, Cross, S & Lipman, J 2008, 'A novel way to investigate the effects of plasma exchange on antibiotic levels- the use of microdialysis', International Journal of Antimicrobial Agents, vol. 31, no. 3, pp. 240-244. 12 21
2008	Roberts, MS, Roberts, M, Robertson, TA, Sanchez, W, Thorling, C, Zou, Y, Zhao, X & Zvyagin, A 2008, 'In vitro and in vivo imaging of xenobiotic transport in human skin and in the rat liver'. Open access 83 73
2008	Weiss, M, Hung, D, Poenicke, K & Roberts, MS 2008, 'Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin', European Journal of Pharmaceutical Sciences, vol. 34, no. 4-5, pp. 345-350. 13 14
2008	Winckle, G, Anissimov, Y, Cross, S, Wise, G & Roberts, MS 2008, 'An integrated pharmacokinetic and imagine evaluation of vehicle effects on solute human epidermal flux and, retention characteristics', Pharmaceutical Research, vol. 25, no. 1, pp. 158-166. 9 6
2008	Yan, L, Ropella, G, Park, S, Roberts, MS & Hunt, A 2008, 'Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver', Pharmaceutical Research, vol. 25, no. 5, pp. 1023-1036. 34 30

Conferences

Year	Output
2016	Liang, X, Wang, H, Liu, X & Roberts, M 2016, 'Quantitative optical imaging of paracetamol-induced metabolism changes in the liver', SPIE, vol. 10013, article no. 100131H, pp. 1-4. Open access
2016	Liu, X, Liang, X, Wang, H, Roberts, DM & Roberts, MS 2016, 'Multiphoton imaging for assessing renal disposition in acute kidney injury', SPIE BioPhotonics Australasia, SPIE, vol. 10013, article no. 100131F, pp. 1-4. Open access
2016	Thorling (Thompson), C, Wang, H, Liu, X, Liang, X, Crawford, DH & Roberts, MS 2016, 'Non-invasive assessment of the liver using imaging', SPIE, vol. 10013, article no. 100131J, pp. 1-5. Open access
2016	Thorling, CA, Studier, H, Crawford, D & Roberts, MS 2016, 'Using multiphoton fluorescence lifetime imaging to characterize liver damage and fluorescein disposition in liver in vivo', Multiphoton Microscopy in the Biomedical Sciences XVI, SPIE, vol. 9712, article no. 97120Y, pp. 1-12. 1
2016	Wang, H, Jayachandran, A, Gravot, G, Liang, X, Thorling, CA, Zhang, R, Liu, X & Roberts, MS 2016, 'In vivo quantitative visualization of hypochlorous acid in the liver using a novel selective two-photon fluorescent probe', SPIE BioPhotonics Australasia, SPIE. Open access
2008	Prow, TW, Chen, X, Crichton, M, Tiwari, Y, Gradassi, F, Raphelli, K, Mahony, D, Fernando, G, Roberts, MS & Kendall, MA 2008, 'Targeted epidermal delivery of vaccines from coated micro-nanoprojection patches', International Conference on Nanoscience and Nanotechnology, ICONN 2008, IEEE, no. article no. 4639262, pp. 125-128. 2 1
2008	Roberts, MS 2008, 'Quantum Dots.'.

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Acino Pharma AG	GERMANY
ACT Pathology	AUSTRALIA
Alexandria University	EGYPT
An-eX Analytical Services Ltd	UNITED KINGDOM
Anhui Medical University	CHINA
Austin Health	AUSTRALIA
Austin Hospital	AUSTRALIA
Australian National University	AUSTRALIA
Australian Synchrotron Company Ltd	AUSTRALIA
Autonomous University of Barcelona	SPAIN
Babraham Institute	UNITED KINGDOM
Beatson Institute for Cancer Research	UNITED KINGDOM
Becker and Hickl GmbH	GERMANY
Becker Hickl GmbH	GERMANY
Blacktown Hospital	AUSTRALIA
Bundaberg Hospital	AUSTRALIA
Calvary Mater Hospital	AUSTRALIA
Canberra Hospital	AUSTRALIA
Changzheng Hospital	CHINA
Charité - Universitätsmedizin Berlin	GERMANY
Chiang Mai University	THAILAND
Childrens Hospital at Westmead	AUSTRALIA
China Pharmaceutical University	CHINA
Colorado School of Mines	UNITED STATES
Curtin University	AUSTRALIA
Dalian University of Technology	CHINA
Duke University	UNITED STATES
Federal University of Sao Paulo	BRAZIL
Food and Drug Administration	UNITED STATES
Garvan Institute of Medical Research	AUSTRALIA
General Hospital of Heidenheim	GERMANY
Ghent University	BELGIUM
Goethe University Frankfurt	GERMANY
Greenslopes Private Hospital	AUSTRALIA
Griffith University	AUSTRALIA
Helwan University	EGYPT
Heriot-Watt University	UNITED KINGDOM
Imaginot Pty Ltd	AUSTRALIA
INM Institute	GERMANY
Institut Polytechnique Lasalle-Beauvais	FRANCE
Ipswich Hospital	AUSTRALIA
JenLab GmbH	GERMANY
Joanneum Research	AUSTRIA
John Fawkner Private Hospital	AUSTRALIA
Johnson & Johnson	UNITED STATES
Johnson and Johnson Asia Pacific	UNITED STATES
King Saud University	SAUDI ARABIA
Leiden University	NETHERLANDS
Linköping University	SWEDEN
Lomonosov Moscow State University	RUSSIAN FEDERATION
Macquarie	AUSTRALIA
Macquarie University	AUSTRALIA
Manipal University	INDIA
Martin Luther University Halle-Wittenberg	GERMANY
Massachusetts General Hospital	UNITED STATES
Monash University	AUSTRALIA
Moscow State University	RUSSIAN FEDERATION
Nanjing University	CHINA
Nanjing University of Science and Technology	CHINA
National Chiao Tung University	TAIWAN
National Institute for Occupational Safety and Health	UNITED STATES
Nepean Hospital	AUSTRALIA
Nimes University Hospital	FRANCE
North Carolina State University - Raleigh	UNITED STATES
Northern Territory Government	AUSTRALIA
Pfizer Global Research and Development	UNITED STATES
Prince of Wales Hospital	AUSTRALIA
Princess Alexandra Hospital	AUSTRALIA
Princess Alexandra Hospital Brisbane	AUSTRALIA
Private Individual	AUSTRALIA
Proctor and Gamble Eurocor	BELGIUM
Public Health Virology, Queensland Health Forensic and Scientific Services	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queensland Health	AUSTRALIA
Queensland Institute of Medical Research	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Quest Pharmaceutical	UNITED STATES
Repatriation General Hospital	AUSTRALIA
Rhodes University	SOUTH AFRICA
Royal Adelaide Hospital	AUSTRALIA
Royal Brisbane & Women's Hospital	AUSTRALIA
Royal Brisbane and Women's Hospital	AUSTRALIA
Royal Darwin Hospital	AUSTRALIA
Royal North Shore Hospital	AUSTRALIA
Royal Perth Hospital	AUSTRALIA
Royal Prince Alfred Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Saarland University	GERMANY
Sechenov First Moscow State Medical University	RUSSIAN FEDERATION
Second Military Medical University	CHINA
Shahid Beheshti University	IRAN
Shahid Beheshti University of Medical Sciences	IRAN
Shanghai Jiao Tong University	CHINA
Shimadzu Australasia	AUSTRALIA
Soochow University	CHINA
St Vincent's Hospital	AUSTRALIA
St. Thomas Hospital	UNITED STATES
Storith Consulting Ltd.	UNITED KINGDOM
Tabriz University of Medical Sciences	IRAN
Tehran University of Medical Sciences	IRAN
Temasek Polytechnic	SINGAPORE
The Alfred Hospital	AUSTRALIA
Translational Research Institute	UNITED STATES
Universita Degli Studi di Milano	ITALY
Universite de Rennes	FRANCE
University Claude Bernard	FRANCE
University College London	UNITED KINGDOM
University Libre Bruxelles	BELGIUM
University of Adelaide	AUSTRALIA
University of Alberta	CANADA
University of Basel	SWITZERLAND
University of Bath	UNITED KINGDOM
University of Bern	SWITZERLAND
University of California San Francisco	UNITED STATES
University of California System	UNITED STATES
University of California, Berkeley	UNITED STATES
University of Cincinnati	UNITED STATES
University of Edinburgh	UNITED KINGDOM
University of Groningen	NETHERLANDS
University of Guelph	CANADA
University of Halle-Wittenberg	GERMANY
University of Kelaniya	SRI LANKA
University of Konstanz	GERMANY
University of Lausanne	SWITZERLAND
University of Liverpool	UNITED KINGDOM
University of London	UNITED KINGDOM
University of Manitoba	CANADA
University of Maryland	UNITED STATES
University of Melbourne	AUSTRALIA
University of Michigan	UNITED STATES
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Otago	NEW ZEALAND
University of Oulu	FINLAND
University of Peradeniya	SRI LANKA
University of Pittsburgh	UNITED STATES
University of Queensland	AUSTRALIA
University of Queesland	AUSTRALIA
University Of Rennes 1	FRANCE
University of Sao Paulo	BRAZIL
University of South Australia	AUSTRALIA
University of Southampton	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Tasmania	AUSTRALIA
University of Tehran	IRAN
University of Toronto	CANADA
University of Utah	UNITED STATES
Wake Forest University School of Medicine	UNITED STATES
Western Health Victoria	AUSTRALIA
Western Sydney Health	AUSTRALIA
Westmead Hospital	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
Zagazig University	EGYPT

External engagement & recognition

Engagement/recognition	Year
Senior Principal Research Fellow National Health and Medical Research Council (NHMRC)	2018
Advisory Board Member, Cosmetic Advisory Committee Australian Government	2017
Consultant, Chemical Safety and Environmental Health Branch Australian Government	2017
Member International Skin Pharmacology and Physiology	2017
Member American Association of Pharmaceutical Scientists	2017
Member Controlled Release Society	2017
Member Pharmaceutical Society of Australia	2017
Member Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT)	2017
Member Australasian Pharmaceutical Science Association	2017
Member National Industrial Chemicals Notification and Assessment Scheme (NICNAS)	2017
Member, Pharmaceutical Subcommittee (PSC) Australian Drug Evaluation Committee (ADEC)	2017
Senior Principal Research Fellow National Health and Medical Research Council (NHMRC)	2017
Visiting Professeur University of Lyon, France	2017
Fellow Australian Academy of Health and Medical Science	2015
Fellowship National Health and Medical Research Council (NHMRC)	2013
Fellowship worth $1.6 million National Health and Medical Research Council (NHMRC)	2011
Senior Principal Research Fellow National Health and Medical Research Council (NHMRC)	2011
Senior Principal Research Fellow National Health and Medical Research Council (NHMRC)	2009

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Atrial fibrillation associated Transient Ischemic attack: use of thromboprophylaxis and implications for morbidity and mortality	Current
Exploring the hair follicles as targets to improve the effectiveness of antidandruff therapies	Current
Investigation of the pharmacokinetics pharmacodynamics of per- and polyfluoroalkyl substances (PFAS) in food production animals and development of models to predict biological loading and potential	Current
Managing poly-pharmacy and therapeutic risk in older and indigenous Australian patients	Current
Obesity and depression: a study on causality and gene-environment interactions	Current
Proteomic Study of Hepatitis C virus by LC Tandem Mass Spectrometry	Current
Quantification, pharmacokinetics and efficacy of drug poisoning treatment	Current
Rheumatoid arthritis is a potentially disabling form of arthritis associated with erosive joint destruction and subsequent deformity, pain and increased mortality	Current
Development and feasibility of a patient-centred deprescribing process	Completed
Does vitamin D deficiency contribute to endothelial dysfunction?	Completed
Getting through the skin’s formidable barrier – understanding the role of solute structure, skin morphology and formulation in skin delivery	Completed
Improving antifungal use in the critically ill: a pharmacokinetic/pharmacodynamic approach	Completed
In vitro dissolution testing in relation to in vivo performance of drugs	Completed
Intracellular signal transduction and modulation of P2Y12 receptor signaling in health and disease	Completed
Skin deep – understanding the transport within the skin and nail for formulation design	Completed
Structural determinants and formulation effects on percutaneous absorption	Completed
The impact and outcomes of services provided by the pharmacist to improve quality use of medicines in Australian population	Completed
The role of formulations in skin delivery	Completed
The use of multiphoton microscopy in the study of transmembrane drug transport in hepatic ischemia reperfusion injury	Completed
Therapeutic drug monitoring of beta-lactam antibiotics in patients at high risk of therapeutic failure: a pharmacokinetic and pharmacodynamic investigation	Completed

Professor Michael Roberts

About me

About me

School of Pharmacy and Medical Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Books

Chapters

Journal Articles

Conferences

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Senior Principal Research Fellow

Advisory Board Member, Cosmetic Advisory Committee

Consultant, Chemical Safety and Environmental Health Branch

Member

Member

Member

Member

Member

Member

Member

Member, Pharmaceutical Subcommittee (PSC)

Senior Principal Research Fellow

Visiting Professeur

Fellow

Fellowship

Fellowship worth $1.6 million

Senior Principal Research Fellow

Senior Principal Research Fellow

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery