Associate Professor Michael Wiese

Associate Professor in Pharmacotherapeutics UniSA Clinical & Health Sciences

City West Campus (HB6-30)
tel +61 8 830 22312

email Michael.Wiese@unisa.edu.au

Research Degree Supervisor

About me

Welcome to my home page. I am a registered pharmacist and worked in practice for 10 years prior to joining the staff at the University in 2008. I am interested in the clinical use of medicines, and my predominant teaching role is in the pharmacotherapeutics subjects of the 3rd year of the Undergraduate Pharmacy Program.

My primary research interests are personalised medicine (including pharmacogenomics and drug concentration effect relationships, particularly in patients with rheumatoid arthritis), drug allergy and deprescribing (the process of ceasing redundant medications).

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research focus

Clinical Sciences
Pharmacology and Pharmaceutical Sciences
Public Health and Health Services
Biochemistry and Cell Biology
Immunology

Highlights

Personalised medicine, primarily improving the efficiency of drug dosage regimens according to patient specific factors, and the use of therapeutic drug monitoring to improve efficacy and reduce toxicity of medications.
Drug Allergy, including the development of in vitro diagnostic techniques,Identification of strategies to cease redundant medications
The use of venom immunotherapy to desensitise patients who are allergic to ant venom, including laboratory invetigations to identify patients at risk of failure of therapy or of side effects.

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Meakin, AS, Amirmostofian, M, Darby, JR, Holman, SL, Morrison, JL & Wiese, MD 2023, 'Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes', Placenta, vol. 131, no. , pp. 82-89.
2022	Al-Qurain, AA, Upton, RN, Tadros, R, Roberts, MS & Wiese, MD 2022, 'Population pharmacokinetic model for tramadol and O-desmethyltramadol in older patients', European Journal of Drug Metabolism and Pharmacokinetics, vol. 47, no. 3, pp. 387-402. Open access
2022	Alshabrawy, AK, Cui, Y, Sylvester, C, Yang, D, Petito, ES, Barratt, KR, Sawyer, RK, Heatlie, JK, Polara, R, Sykes, MJ, Atkins, GJ, Hickey, SM, Wiese, MD, Stringer, AM, Liu, Z & Anderson, PH 2022, 'Therapeutic potential of a novel vitamin D3 oxime analogue, VD1‐6, with CYP24A1 enzyme inhibitory activity and negligible vitamin D receptor binding', Biomolecules, vol. 12, no. 7, article no. 960. Open access
2022	Braithwaite, FA, Noel, M, Jones, HG, Wiese, MD, Nania, CG, Watson, E & Stanton, TR 2022, 'Reframe the pain: divided attention and positive memory reframing to reduce needle pain and distress in children-a feasibility randomized controlled trial', European Journal of Pain, vol. 26, no. 8, pp. 1702-1722. Open access 335
2022	Manning-Bennett, AT, Hopkins, AM, Sorich, MJ, Proudman, SM, Foster, DJ, Abuhelwa, AY & Wiese, MD 2022, 'The association of depression and anxiety with treatment outcomes in patients with rheumatoid arthritis - a pooled analysis of five randomised controlled trials', Therapeutic Advances in Musculoskeletal Disease, vol. 14, pp. 1-14. Open access
2022	Meakin, AS, Darby, JR, Holman, SL, Wiese, MD & Morrison, JL 2022, 'Maternal-placental-fetal drug metabolism is altered by late gestation undernutrition in the pregnant ewe', Life Sciences, vol. 298, article no. 120521, pp. 1-9.
2022	Modi, ND, Abuhelwa, AY, McKinnon, RA, Boddy, A V, Haseloff, M, Wiese, MD, Hoffmann, TC, Perakslis, ED, Rowland, A, Sorich, MJ & Hopkins, AM 2022, 'Audit of data sharing by pharmaceutical companies for anticancer medicines approved by the us food and drug administration', JAMA Oncology, vol. 8, no. 9, pp. 1310-1316. Open access
2022	Morrison, JL, Williams, GK, Cho, SK, Saini, BS, Meakin, AS, Holman, SL, Quinn, M, Wiese, MD, Macgowan, CK, Seed, M & Darby, JR 2022, 'MRI Characterization of blood flow and oxygen delivery in the fetal sheep whilst exposed to sildenafil citrate', Neonatology: Foetal and Neonatal Research, online, pp. 1-10. Open access
2022	Tan, E, Abuhelwa, AY, Badaoui, S, Modi, ND, Wiese, MD, Mckinnon, RA, Sorich, MJ & Hopkins, AM 2022, 'Association between patient-reported outcomes and survival in patients with advanced urothelial carcinoma treated with atezolizumab', Bladder Cancer, vol. 8, no. 1, pp. 81-88. Open access
2022	Wanandy, T, Mulcahy, E, Lau, WY, Brown, SG & Wiese, MD 2022, 'Global view on ant venom allergy: from allergenic components to clinical management', Clinical Reviews in Allergy and Immunology, vol. 62, no. 1, pp. 123-144. 1 1
2022	Wiese, MD, Berry, MJ, Hissaria, P, Darby, JR & Morrison, JL 2022, 'COVID-19: Can we treat the mother without harming her baby?', Journal of Developmental Origins of Health and Disease, vol. 13, pp. 9-19. Open access 2 13
2021	Abuhelwa, AY, Foster, DJ, Manning-Bennett, A, Sorich, MJ, Proudman, S, Wiese, MD & Hopkins, AM 2021, 'Concomitant beta-blocker use is associated with a reduced rate of remission in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs: a post hoc multicohort analysis', Therapeutic Advances in Musculoskeletal Disease, vol. 13, pp. 1-7. Open access 4
2021	Al-Qurain, AA, Gebremichael, LG, Khan, MS, Williams, DB, Mackenzie, L, Phillips, C, Russell, P, Roberts, MS & Wiese, MD 2021, 'Opioid prescribing and risk of drug-opioid interactions in older discharged patients with polypharmacy in Australia', International Journal of Clinical Pharmacy, vol. 43, no. 2, pp. 365-374. 1 2 4
2021	Al-Qurain, AA, Upton, R, Williams, DB, Mackenzie, L, Phillips, C, Russell, PT, Tadros, R, Roberts, MS & Wiese, MD 2021, 'Population pharmacokinetic model of subcutaneous fentanyl in older acute care patients', European Journal of Clinical Pharmacology, vol. 77, no. 9, pp. 1357-1368. 1
2021	Al-Qurain, AA, Williams, DB, Mackenzie, L, Roberts, MS & Wiese, MD 2021, 'Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling', Journal of Pharmaceutical and Biomedical Analysis, vol. 203, article no. 114171, pp. 1-8. 2 2 2
2021	Alshabrawy, AK, Bergamin, A, Sharma, DK, Hickey, SM, Brooks, DA, O'Loughlin, P, Wiese, MD & Anderson, PH 2021, 'LC-MS/MS analysis of vitamin D3 metabolites in human serum using a salting-out based liquid-liquid extraction and DAPTAD derivatization', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1173, article no. 122654. 3 1 1
2021	Aujla, T, Darby, JR, Saini, BS, Lock, MC, Holman, SL, Bradshaw, EL, Perumal, SR, McInnes, SJ, Voelcker, NH, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep', Experimental Physiology, vol. 106, no. 5, pp. 1166-1180. Open access 1 2 10
2021	Daraghmeh, DN, King, C & Wiese, MD 2021, 'A review of liquid biopsy as a tool to assess epigenetic, cfDNA and miRNA variability as methotrexate response predictors in patients with rheumatoid arthritis', Pharmacological Research, vol. 173, article no. 105887, pp. 1-9. 4 5
2021	Deng, I, Wiese, MD, Zhou, XF & Bobrovskaya, L 2021, 'The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice', NeuroToxicology, vol. 85, pp. 254-264. Open access 4 3 1
2021	Dimasi, CG, Lazniewska, J, Plush, SE, Saini, BS, Holman, SL, Cho, SK, Wiese, MD, Sorvina, A, Macgowan, CK, Seed, M, Brooks, DA, Morrison, JL & Darby, JR 2021, 'Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output', Journal of Biophotonics, vol. 14, no. 12, article no. e202100157, pp. 1-13. Open access 4 4 7
2021	Gebremichael, LG, Suppiah, V, Wiese, MD, Mackenzie, L, Phillips, C, Williams, DB & Roberts, MS 2021, 'Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care', Pharmacogenomics, vol. 22, no. 9, pp. 553-571. 1
2021	Maher, D, Ailabouni, N, Mangoni, AA, Wiese, MD & Reeve, E 2021, 'Alterations in drug disposition in older adults: a focus on geriatric syndromes', Expert Opinion on Drug Metabolism and Toxicology, vol. 17, no. 1, pp. 41-52. Open access 14 14 8
2021	McBride, GM, Meakin, AS, Soo, JY, Darby, JR, Varcoe, TJ, Bradshaw, EL, Lock, MC, Holman, SL, Saini, BS, Macgowan, CK, Seed, M, Berry, MJ, Wiese, MD & Morrison, JL 2021, 'Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit', Life Sciences, vol. 285, article no. 120016, pp. 1-9. Open access 2 1 8
2021	Modi, ND, Tan, JQE, Rowland, A, Koczwara, B, Abuhelwa, AY, Kichenadasse, G, McKinnon, RA, Wiese, MD, Sorich, MJ & Hopkins, AM 2021, 'The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data', npj Breast Cancer, vol. 7, no. 1, article no. 30, pp. 1-6. Open access 9 8 63
2021	Wiese, MD, Hopkins, AM, King, C, Wechalekar, MD, Lee, A, Spargo, L, Metcalf, R, McWilliams, L, Hill, C, Cleland, LG & Proudman, SM 2021, 'Precision medicine with leflunomide: consideration of DHODH haplotype and plasma teriflunomide concentration can substantially modify outcomes in patients with rheumatoid arthritis', Arthritis Care and Research, vol. 73, no. 7, pp. 983-989. Open access 2 2 12
2021	Wiese, MD, Meakin, AS, Varcoe, TJ, Darby, JR, Sarr, O, Kiser, P, Bradshaw, EL, Regnault, TR & Morrison, JL 2021, 'Hepatic cytochrome P450 function is reduced by life-long Western diet consumption in guinea pig independent of birth weight', Life Sciences, vol. 287, article no. 120133, pp. 1-11. 2 2 3
2020	Abuhelwa, AY, Hopkins, AM, Sorich, MJ, Proudman, S, Foster, DJ & Wiese, MD 2020, 'Association between obesity and remission in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs', Scientific Reports, vol. 10, article no. 18634. Open access 5 6 1
2020	Al-Qurain, AA, Gebremichael, LG, Khan, MS, Williams, DB, Mackenzie, L, Phillips, C, Russell, P, Roberts, MS & Wiese, MD 2020, 'Prevalence and factors associated with analgesic prescribing in poly-medicated elderly patients', Drugs and Aging, vol. 37, no. 4, pp. 291-300. 8 7 2
2020	Hopkins, AM, Menz, BD, Wiese, MD, Kichenadasse, G, Gurney, H, McKinnon, RA, Rowland, A & Sorich, MJ 2020, 'Nuances to precision dosing strategies of targeted cancer medicines', Pharmacology Research and Perspectives, vol. 8, no. 4, article no. e00625, pp. 1-9. Open access 3 3 6
2020	McBride, GM, Soo, JY, Varcoe, T, Morrison, JL & Wiese, MD 2020, 'Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes', Journal of Pharmacological and Toxicological Methods, vol. 106, pp. 1-8. 4 4 2
2020	McBride, GM, Wiese, MD, Soo, JY, Darby, JR, Berry, MJ, Varcoe, TJ & Morrison, JL 2020, 'The impact of intrauterine growth restriction on cytochrome P450 enzyme expression and activity', Placenta, vol. 99, pp. 50-62. 1 1 79
2020	Modi, ND, Sorich, MJ, Rowland, A, Logan, JM, McKinnon, RA, Kichenadasse, G, Wiese, MD & Hopkins, AM 2020, 'A literature review of treatment-specific clinical prediction models in patients with breast cancer', Critical Reviews in Oncology Hematology, vol. 148, article no.102908, pp. 1-8. Open access 8 7 3
2020	Modi, ND, Sorich, MJ, Rowland, A, McKinnon, RA, Koczwara, B, Wiese, MD & Hopkins, AM 2020, 'Predicting thrombocytopenia in patients with breast cancer treated with ado-trastuzumab emtansine', Clinical Breast Cancer, vol. 20, no. 2, pp. e220-e228. 5 5
2020	Modi, ND, Tan, JQE, Rowland, A, Koczwara, B, Kichenadasse, G, McKinnon, RA, Wiese, MD, Sorich, MJ & Hopkins, AM 2020, 'The influence of pre-existing beta-blockers use on survival outcomes in HER2 positive advanced breast cancer: pooled analysis of clinical trial data', Frontiers in Oncology, vol. 10, article no. 1130, pp. 1-6. Open access 4 4 62
2020	Reid, AB, Wiese, M, McWilliams, L, Metcalf, R, Hall, C, Lee, A, Hill, C, Wechalekar, M, Cleland, L & Proudman, SM 2020, 'Repeat serological testing for anti-citrullinated peptide antibody after commencement of therapy is not helpful in patients with seronegative rheumatoid arthritis', Internal Medicine Journal, vol. 50, no. 7, pp. 818-822. 2 2 6
2020	Soo, J, Wiese, MD, Dyson, R, Gray, C, Clarkson, A, Morrison, JL & Berry, M 2020, 'Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs', PLoS One, vol. 15, no. 5, article no. e0233010, pp. 1-16. Open access 5 4
2020	Varcoe, TJ, Darby, JR, Holman, SL, Bradshaw, EL, Kuchel, T, Vaughan, L, Seed, M, Wiese, MD & Morrison, JL 2020, 'Fetal cardiovascular response to acute hypoxia during maternal anesthesia', Physiological Reports, vol. 8, no. 3, article no. e14365, pp. 1-15. Open access 6 6 4
2020	Wiese, MD, Manning-Bennett, AT & Abuhelwa, AY 2020, 'Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis', Expert Opinion on Investigational Drugs, vol. 29, no. 5, pp 475-482. Open access 17 17
2019	Darby, JR, Saini, BS, Soo, JY, Lock, MC, Holman, SL, Bradshaw, EL, McInnes, SJ, Voelcker, NH, Macgowan, CK, Seed, M, Wiese, MD & Morrison, JL 2019, 'Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth', The Journal of Physiology, vol. 597, no. 20, pp. 5063-5077. Open access 12 13 9
2019	Varcoe, TJ, Darby, JR, Gatford, KL, Holman, SL, Cheung, P, Berry, MJ, Wiese, MD & Morrison, JL 2019, 'Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery', Animal Frontiers, vol. 9, no. 3, pp. 60-67. Open access 24 22 3
2019	Wabe, N, Lee, A, Wechalekar, M, McWilliams, L, Proudman, S & Wiese, M 2019, 'Factors associated with medication adherence in a longitudinal study of rheumatoid arthritis patients', International Journal of Clinical Practice, vol. 73, no. 7, article no. e13375, pp. 1-9. Open access 10 11 1
2019	Wanandy, T, Honda-Okubo, Y, Davies, NW, Rose, HE, Heddle, RJ, Brown, SG, Woodman, RJ, Petrovsky, N & Wiese, MD 2019, 'Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy', Journal of Pharmaceutical and Biomedical Analysis, vol. 172, pp. 1-8. Open access 4 4
2018	Baghdadi, LR, Woodman, RJ, Shanahan, EM, Wiese, MD & Mangoni, AA 2018, 'Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study', Pharmacogenomics and Personalized Medicine, vol. 11, pp. 205-210. Open access 8 6 4
2018	Polasek, TM, Tucker, GT, Sorich, MJ, Wiese, MD, Mohan, T, Rostami-Hodjegan, A, Korprasertthaworn, P, Perera, V & Rowland, A 2018, 'Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation', British Journal of Clinical Pharmacology, vol. 84, no. 3, pp. 462-476. Open access 35 33 66
2018	Soo, JY, Wiese, MD, Berry, MJ & Morrison, JL 2018, 'Does poor fetal growth influence the extent of fetal exposure to maternal medications?', Pharmacological Research, vol. 130, pp. 74-84. 8 8 1
2018	Soo, JY, Wiese, MD, Berry, MJ, McMillen, IC & Morrison, JL 2018, 'Intrauterine growth restriction may reduce hepatic drug metabolism in the early neonatal period', Pharmacological Research, vol. 134, pp. 68-78. 12 12 1
2018	Wanandy, T, Wilson, R, Gell, D, Rose, HE, Gueven, N, Davies, NW, Brown, SG & Wiese, MD 2018, 'Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach', Clinical and Experimental Allergy, vol. 48, no. 9, pp. 1222-1234. 9 8
2017	Dias, M, Sorich, MJ, Rowland, A, Wiese, MD & McKinnon, RA 2017, 'The routine clinical use of pharmacogenetic tests: what it will require?', Pharmaceutical Research, vol. 34, no. 8, pp. 1544-1550. 13 13 3
2017	Hopkins, AM, Moghaddami, M, Foster, DJ, Proudman, SM, Upton, RN & Wiese, MD 2017, 'Intracellular CD3(+) T lymphocyte teriflunomide concentration is poorly correlated with and has greater variability than unbound plasma teriflunomide concentration', Drug Metabolism and Disposition, vol. 45, no. 1, pp. 8-16. Open access 6 6
2017	Hopkins, AM, Rowland, A, Kichenadasse, G, Wiese, MD, Gurney, H, McKinnon, RA, Karapetis, CS & Sorich, MJ 2017, 'Predicting response and toxicity to immune checkpoint inhibitors using routinely available blood and clinical markers', British Journal of Cancer, vol. 117, no. 7, pp. 913-920. Open access 113 111 11
2017	Hopkins, AM, Wiese, MD, O'Doherty, CE & Proudman, SM 2017, 'Putting recommendations into practice: Australian rheumatologists' opinions on leflunomide use in rheumatoid arthritis', Clinical Rheumatology, vol. 36, no. 4, pp. 791-798. 2 2
2017	Mangoni, AA, Baghdadi, LR, Shanahan, EM, Wiese, MD, Tommasi, S, Elliot, D & Woodman, RJ 2017, 'Methotrexate, blood pressure and markers of arterial function in patients with rheumatoid arthritis: a repeated cross-sectional study', Therapeutic Advances in Musculoskeletal Disease, vol. 9, no. 9, pp. 213-229. Open access 22 18
2017	Maundrell, A, Lester, S, Rischmueller, M, Hill, C, Cleland, LG, Blumbergs, P, Wiese, M & Limaye, V 2017, 'The PTPN22 gene is associated with idiopathic inflammatory myopathy', Muscle and Nerve, vol. 55, no. 2, pp. 270-273. 3 4
2017	Rowland, A, Van Dyk, M, Mangoni, AA, Miners, JO, McKinnon, RA, Wiese, MD, Rowland, A, Kichenadasse, G, Gurney, H & Sorich, MJ 2017, 'Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure', Expert Opinion on Drug Metabolism and Toxicology, vol. 13, no. 1, pp. 31-49. 44 42 1
2017	Tait, PA, Cheung, WH, Wiese, M & Staff, K 2017, 'Improving community access to terminal phase medicines in Australia: Identification of the key considerations for the implementation of a 'core medicines list'', Australian Journal of Primary Health, vol. 23, no. 4, pp. 373-378. 2 2 6
2017	Wabe, N & Wiese, MD 2017, 'Treating rheumatoid arthritis to target: physician and patient adherence issues in contemporary rheumatoid arthritis therapy', Journal of Evaluation in Clinical Practice, vol. 23, no. 3, pp. 486-493. 11 9
2017	Wabe, N, Lee, A, Wechalekar, MD, McWilliams, L, Proudman, SM & Wiese, M 2017, 'Adherence to combination DMARD therapy and treatment outcomes in rheumatoid arthritis: a longitudinal study of new and existing DMARD users', Rheumatology International, vol. 37, no. 6, pp. 897-904. 14 15 1
2017	Wabe, N, Sorich, MJ, Wechalekar, MD, Cleland, LG, McWilliams, L, Lee, A, Spargo, L, Metcalf, R, Hall, C, Proudman, SM & Wiese, MD 2017, 'Determining the acceptable level of physician compliance with a treat-to-target strategy in early rheumatoid arthritis', International Journal of Rheumatic Diseases, vol. 20, no. 5, pp. 576-583. 5 5
2017	Wabe, N, Wojciechowski, J, Wechalekar, MD, Cleland, LG, McWilliams, L, Lee, A, Proudman, S & Wiese, MD 2017, 'Disease activity trajectories in early rheumatoid arthritis following intensive DMARD therapy over 3 years: association with persistence to therapy', International Journal of Rheumatic Diseases, vol. 20, no. 10, pp. 1447-1456. 7 8
2017	Wanandy, T, Dwyer, H, McLean, L, Davies, N, Nichols, D, Gueven, N, Brown, S & Wiese, M 2017, 'Factors influencing the quality of Myrmecia pilosula (Jack Jumper) ant venom for use in in vitro and in vivo diagnoses of allergen sensitization and in allergen immunotherapy', Clinical and Experimental Allergy, vol. 47, no. 11, pp. 1478-1490. 4 4
2017	Wimmer, BC, Cross, AJ, Jokanovic, N, Wiese, MJ, George, J, Johnell, K, Diug, B & Bell, JS 2017, 'Clinical outcomes associated with medication regimen complexity in older people: a systematic review', Journal of the American Geriatrics Society, vol. 65, no. 4, pp. 747-753. 100 103 41
2017	Wojciechowski, J, Upton, RN, Mould, DR, Wiese, MD & Foster, DJ 2017, 'Infliximab maintenance dosing in inflammatory bowel disease: an example for in silico assessment of adaptive dosing strategies', AAPS Journal, 19, no. 4, pp. 1136-1147. 22 24 4
2016	Hopkins, AM, Proudman, SM, Vitry, A, Sorich, MJ, Cleland, LG & Wiese, MD 2016, 'Ten years of Publically Funded Biological Disease Modifying Antirheumatic Agents in Australia', Medical Journal of Australia, vol. 204, no. 2, pp. 64-68. Open access 14 3 1
2016	Hopkins, AM, Wiese, MD, Proudman, SM, O'Doherty, CE, Upton, RN & Foster, DJR 2016, 'Genetic polymorphism of CYP1A2 but not total or free teriflunomide concentrations is associated with leflunomide cessation in rheumatoid arthritis', British Journal of Clinical Pharmacology, vol. 81, no. 1, pp. 113-123. 8 14
2016	Lester, S, Hewitt, AW, Ruediger, CD, Bradbury, L, De Smit, E, Wiese, MD, Black, R, Harrison, A, Jones, G, Littlejohn, GO, Merriman, TR, Shenstone, B, Smith, MD, Rischmueller, M, Brown, MA & Hill, CL 2016, 'PTPN22 R620W minor allele is a genetic risk factor for giant cell arteritis', RMD Open, vol. 2, no. 1, article no. e000246, pp. 1-3. Open access 7 9
2016	Polasek, TM, Ambler, K, Scott, HS, Sorich, MJ, Kaub, PA, Rowland, A, Wiese, MD & Kichenadasse, G 2016, 'Targeted pharmacotherapy after somatic cancer mutation screening', F1000Research, vol. 5, article no. 1551, pp. 1-8. Open access 8 1
2016	Rowland, A, Dias, MM, Wiese, MD, Kichenadasse, G, McKinnon, RA, Karapetis, CS & Sorich, MJ 2016, 'Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours', European Journal of Cancer, vol. 55, pp. 122-130. 24 17 5
2016	Rowland, A, Karapetis, CS, Mangoni, AA, Wiese, MD, Kichenadasse, G, McKinnon, RA & Sorich, MJ 2016, 'Clinical translation of predictive markers for anti-EGFR monoclonal antibody therapy in metastatic colorectal cancer', Translational Cancer Research, vol. 5, pp. S31-S35. 1 1
2016	Shahnam, A, Ridha, Z, Wiese, MD, Kichenadasse, G & Sorich, Mj 2016, 'Pharmacogenetic and ethnicity influence on oxaliplatin therapy for colorectal cancer: a meta-analysis', Pharmacogenomics, vol. 17, no. 15, pp. 1725-1732. 11 7 16
2016	Wabe, N, Sorich, M, Wechalekar, M, Cleland, L, McWilliams, L, Lee, A, Hall, C, Spargo, L, Metcalf, R, Proudman, S & Wiese, M 2016, 'Drug-induced toxicity and patient reported outcomes in rheumatoid arthritis patients following intensive treated-to-target strategy: does ceasing therapy due to toxicity worsen outcomes in long term?', International Journal of Clinical Practice, vol. 70, no. 4, pp. 340-350. 2 2 10
2016	Wabe, NT, Sorich, MJ, Wechalekar, MD, Cleland, LG, McWilliams, L, Lee, AT, Spargo, LD, Metcalf, RG, Hall, C, Proudman, S & Wiese, MD 2016, 'Effect of adherence to protocolized targeted intensifications of disease-modifying antirheumatic drugs on treatment outcomes in rheumatoid arthritis: Results from an Australian early arthritis cohort', Journal of Rheumatology, vol. 43, no. 9, pp. 1643-1649. 8 8 4
2016	Wimmer, BC, Bell, JS, Fastbom, J, Wiese, MD & Johnell, K 2016, 'Medication regimen complexity and number of medications as factors associated with unplanned hospitalizations in older people: a population-based cohort study', Journal of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 71, no. 6, pp. 831-837. Open access 47 50 6
2016	Wimmer, BC, Bell, JS, Fastbom, J, Wiese, MD & Johnell, K 2016, 'Medication regimen complexity and polypharmacy as factors associated with all-cause mortality in older people: a population-based cohort study', Annals of Pharmacotherapy, vol. 50, no. 2, pp. 89-95. Open access 66 71 34
2016	Wojciechowski, J, Wiese, MD, Proudman, SM, Foster, DJ & Upton, RN 2016, 'A model-based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity', British Journal of Clinical Pharmacology, vol. 81, no. 6, pp. 1046-1057. Open access
2015	Hopkins, A, Wiese, M, Proudman, S, O'Doherty, C, Foster, D & Upton, R 2015, 'Semiphysiologically based pharmacokinetic model of leflunomide disposition in rheumatoid arthritis patients', CPT: Pharmacometrics and Systems Pharmacology, vol. 4, no. 6 pp. 362-371. Open access 13 12
2015	Mohamed, HJ, Sorich, MJ, Kowalski, SM, McKinnon, R, Proudman, SM, Cleland, L & Wiese, MD 2015, 'The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies - a systematic review', European Journal of Clinical Pharmacology, v 71, no.4, pp. 411-423. Open access 15 15
2015	Polasek, T, Rowland, A, Wiese, M & Sorich, M 2015, 'Pharmacists in Australian general practice: an opportunity for expertise in precision medicine', Therapeutic Advances in Drug Safety, vol. 6, no. 5, pp. 186-188. Open access
2015	Reeve, E, Andrews, JM, Wiese, MD, Hendrix, I, Roberts, MS & Shakib, S 2015, 'Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors', Annals of Pharmacotherapy, vol. 49, no. 1, pp. 29-38. 59 45 7
2015	Reeve, E, Wiese, MD & Mangoni, AA 2015, 'Alterations in drug disposition in older adults', Expert Opinion on Drug Metabolism and Toxicology, vol. 11, no. 4, pp. 491-508. 59 57 3
2015	Rowland, A, Dias, M, Wiese, M, Kichenadasse, G, McKinnon, R, Karapetis, C & Sorich, M 2015, 'Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer', British Journal of Cancer, vol. 112, pp. 1888-1894. Open access 223 208 20
2015	Sorich, M, Wiese, M, Rowland, A, Kichenadasse, G, McKinnon, R & Karapetis, C 2015, 'Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials', Annals of Oncology. Open access 347 334 17
2015	Wabe, N, Sorich, M, Wechalekar, M, Cleland, L, McWilliams, L, Lee, A, Spargo, L, Metcalf, R, Hall, C, Proudman, S & Wiese, M 2015, 'Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years', Arthritis Research and Therapy, vol.17, pp. 1-14. Open access 20 21
2015	Wanandy, T, Gueven, N, Davies, NW, Brown, SG & Wiese, M 2015, 'Pilosulins: a review of the structure and mode of action of venom peptides from an Australian ant Myrmecia pilosula', Toxicon, vol. 98, no. , pp. 54-61. 23 24 5
2015	Wimmer, BC, Johnell, K, Fastbom, J, Wiese, MD & Bell, SJ 2015, 'Factors associated with medication regimen complexity in older people: a cross-sectional population-based study', European Journal of Clinical Pharmacology, vol. 71, no. 9, pp. 1099-1108. 16 27 3
2014	Hopkins, AM, O'Doherty, C, Foster, D, Suppiah, V, Upton, R, Spargo, L, Cleland, L, Proudman, S & Wiese, M 2014, 'The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity', Journal of Clinical Pharmacy and Therapeutics, vol. 39, no. 5, pp. 555-560. 6 5 1
2014	Hopkins, AM, O'Doherty, CE, Foster, DJR, Upton, RN, Proudman, SM & Wiese, MD 2014, 'Individualization of leflunomide dosing in rheumatoid arthritis patients', Personalized Medicine, vol. 11, no. 4, pp. 449-461. 7 7 1
2014	Reeve, E & Wiese, MD 2014, 'Benefits of deprescribing on patients' adherence to medications', International Journal of Clinical Pharmacy, vol. 36, no. 1, pp. 26-29. 60 54 8
2014	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2014, 'Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process', British Journal of Clinical Pharmacology, vol. 78, no. 4, pp. 738-747. Open access 177 163 47
2014	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2014, 'The benefits and harms of deprescribing', Medical Journal of Australia, vol. 201, no. 7, pp. 386-389. Open access 70 52 15
2014	Russo, PAJ, Banovic, T, Wiese, MD, Whyte, AF & Smith, WB 2014, 'Systemic allergy to EDTA in local anesthetic and radiocontrast media', Journal of Allergy and Clinical Immunology-In Practice, vol. 2, no. 2, pp. 225-229. 16 17 1
2014	Sorich, MJ, Rowland, A, McKinnon, RA & Wiese, MD 2014, 'CYP2C19 genotype has a greater effect on adverse cardiovascular outcomes following percutaneous coronary intervention and in Asian populations treated with Clopidogrel : a meta-analysis', Circulation: Cardiovascular Genetics, vol. 7, no. 6, pp. 895-902. Open access 75 82 1
2014	Stone, SF, Phillips, EJ, Wiese, MD, Heddle, RJ & Brown, SG 2014, 'Immediate-type hypersensitivity drug reactions', British Journal of Clinical Pharmacology, vol. 78, no. 1, pp. 1-13. Open access 36 29 5
2014	Wiese, M, Alotaibi, N, O'Doherty, C, Sorich, M, Suppiah, V, Cleland, L & Proudman, S 2014, 'Pharmacogenomics of NAT2 and ABCG2 influence the toxicity and efficacy of sulphasalazine containing DMARD regimens in early rheumatoid arthritis', Pharmacogenomics Journal, vol. 14, pp. 350-355. Open access 20 19
2014	Wiese, MD, Suppiah, V & O'Doherty, C 2014, 'Metabolic and safety issues for multiple sclerosis pharmacotherapy: opportunities for personalised medicine', Expert Opinion on Drug Metabolism and Toxicology, vol. 10, no. 8, pp. 1145-1159. 2 2 7
2014	Wimmer, BC, Dent, E, Bell, JS, Wiese, MD, Chapman, I, Johnell, K & Visvanathan, R 2014, 'Medication regimen complexity and unplanned hospital readmissions in older people', Annals of Pharmacotherapy, vol. 48, no. 9, pp. 1120-1128. 43 41 9
2014	Wimmer, BC, Dent, E, Visvanathan, R, Wiese, MD, Johnell, K, Chapman, I & Bell, JS 2014, 'Polypharmacy and medication regimen complexity as factors associated with hospital discharge destination among older people: a prospective cohort study', Drugs and Aging, vol. 31, no. 8, pp. 623-630. 34 35 5
2014	Wojciechowski, J, Wiese, MD, Proudman, SM, Foster, DJ & Upton, RN 2014, 'A population model of early rheumatoid arthritis disease activity during treatment with methotrexate, sulfasalazine and hydroxychloroquine', British Journal of Clinical Pharmacology, vol. 79, no. 5, pp. 777-788. Open access 5 4
2013	Polasek, TM, Patel, F, Jensen, BP, Sorich, MJ, Wiese, MD & Doogue, MP 2013, 'Predicted metabolic drug clearance with increasing adult age', British Journal of Clinical Pharmacology, vol. 75, no. 4, pp. 1019-1028. Open access 41 37 8
2013	Reeve, E, Shakib, S, Hendrix, I, Roberts, MS & Wiese, MD 2013, 'Development and validation of the patients' attitudes towards deprescribing (PATD) questionnaire', International Journal of Clinical Pharmacy, vol. 35, no. 1, pp. 51-56. 64 60
2013	Reeve, E, To, J, Hendrix, I, Shakib, S, Roberts, MS & Wiese, MD 2013, 'Patient barriers to and enablers of deprescribing: a systematic review', Drugs and Aging, vol. 30, no. 10, pp. 793-807. Open access 286 265 43
2013	Reeve, E, Wiese, MD, Hendrix, I, Roberts, MS & Shakib, S 2013, 'People's attitudes, beliefs, and experiences regarding polypharmacy and willingness to deprescribe', Journal of the American Geriatrics Society, vol. 61, no. 9, pp. 1508-1514. 154 136 21
2013	Russo, PA, Wiese, MD, Smith, MD, Ahern, MJ, Barbara, JA & Shanahan, EM 2013, 'Leflunomide for inflammatory arthritis in end-stage renal disease on peritoneal dialysis: a pharmacokinetic and pharmacogenetic study', Annals of Pharmacotherapy, vol. 47, no. 3, pp. 15-27. 7 7 1
2013	Sorich, M, Polasek, T & Wiese, M 2013, 'Challenges and limitations in the interpretation of systematic reviews : making sense of clopidogrel and CYP2C19 pharmacogenetics', Clinical Pharmacology and Therapeutics, vol. 94, no. 3, pp. 376-382. 18 20
2013	Sorich, MJ, Horowitz, JD, Sorich, W, Wiese, MD, Pekarsky, B & Karnon, JD 2013, 'Cost-effectiveness of using CYP2C19 genotype to guide selection of clopidogrel or ticagrelor in Australia', Pharmacogenomics, vol. 14, no. 16, pp. 2013-2021. Open access 26 24
2013	Sorich, MJ, Wiese, MD, O'Shea, RL & Pekarsky, B 2013, 'Review of the cost effectiveness of pharmacogenetic-guided treatment of hypercholesterolaemia', PharmacoEconomics, vol. 31, no. 5, pp. 377-391. 15 15 2
2013	Wahab, IA, Pratt, NL, Wiese, MD, Kalisch, LM & Roughead, EE 2013, 'The validity of sequence symmetry analysis (SSA) for adverse drug reaction signal detection', Pharmacoepidemiology and Drug Safety, vol. 22, no. 5, pp. 496-502. 48 46 4
2013	Wiese, MD, Bell, JS, Johnell, K & Wimmer, BC 2013, 'Multidose drug dispensing and optimising drug use in older people', Age and Ageing, vol. 42, no. 5, pp. 556-558. Open access 10 11 3
2013	Wiese, MD, Rowland, A, Polasek, TM, Sorich, MJ & O'Doherty, C 2013, 'Pharmacokinetic evaluation of teriflunomide for the treatment of multiple sclerosis', Expert Opinion on Drug Metabolism and Toxicology, vol. 9, no. 8, pp. 1025-1035. 37 33
2012	Alene, M, Wiese, MD, Angamo, MT, Bajorek, B V, Yesuf, EA & Wabe, NT 2012, 'Adherence to medication for the treatment of psychosis : rates and risk factors in an Ethiopian population', BMC Clinical Pharmacology, vol. 12, article no. 10, pp. 1-9. Open access 15 2
2012	Brown, SG, Wiese, MD, van, EPE, Stone, SF, Chuter, CL, Gunner, J, Wanandy, T, Phillips, M & Heddle, RJ 2012, 'Ultrarush versus semirush initiation of insect venom immunotherapy: a randomized controlled trial', Journal of Allergy and Clinical Immunology, vol. 130, no. 1, pp. 162-168. 37 35 6
2012	Chaudhry, T, Hissaria, P, Wiese, M, Heddle, R, Kette, F & Smith, W 2012, 'Oral drug challenges in non-steroidal anti-inflammatory drug-induced urticaria, angioedema and anaphylaxis', Internal Medicine Journal, vol. 42, no. 6, pp. 665-671. 32 28 8
2012	O'Doherty, C, Schnabl, M, Spargo, L, Cleland, LG, James, M, Proudman, SM & Wiese, MD 2012, 'Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis', Pharmacogenomics, vol. 13, no. 12, pp. 1427-1434. 23 23
2012	Wiese, MD, Schnabl, M, O'Doherty, C, Spargo, LD, Sorich, MJ, Cleland, LG & Proudman, SM 2012, 'Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis', Arthritis Research and Therapy, vol. 14, no. 4, article no. R163, pp. 1-9. Open access 38 35 6
2012	Wiese, MD, Sluggett, JK, Wilson, CJ, Reuter, SE, Turner, SC & Evans, AM 2012, 'Perceived and actual paracetamol dosing in overweight and obese children', European Journal of Hospital Pharmacy: Science and Practice, vol. 19, no. 5, pp. 438-442. 2 2 4
2011	Brown, SG, Van Eeden, PE, Wiese, MD, Mullins, RJ, Solley, GO, Puy, R, Taylor, RW & Heddle, R 2011, 'Causes of ant sting anaphylaxis in Australia: the Australian ant venom allergy study', Medical Journal of Australia, vol. 195, no. 2, pp. 69-73. Open access 24 19
2011	Rakhila, H, Rozek, T, Hopkins, AM, Proudman, S, Cleland, L, James, M & Wiese, M 2011, 'Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS', Journal of Pharmaceutical and Biomedical Analysis, vol. 55, no. 2, pp. 325-331. 32 32
2011	Wiese, MD & Shahnam, H 2011, 'Current status on drug allergy', Melbourne, Australasian Pharmaceutical Pub. Co, vol. 92, no. 1098, pp. 84-88.
2011	Wiese, MD, Davies, NW, Chataway, TK, Milne, RW, Brown, SG & Heddle, RJ 2011, 'Stability of Myrmecia pilosula (Jack Jumper) ant venom for use in immunotherapy', Journal of Pharmaceutical and Biomedical Analysis, vol. 54, no. 2, pp. 303-310. 10 10
2011	van Eeden, PE, Wiese, MD, Aulfrey, S, Hales, BJ, Stone, SF & Brown, SG 2011, 'Using time-resolved fluorescence to measure serum venom-specific IgE and IgG', PLoS One, vol. 6, no. 1, article no. 16741. Open access 8 8
2008	Inagaki, H, Akagi, M, Imai, HT, Taylor, R, Wiese, MD, Davies, N & Kubo, T 2008, 'Pilosulin 5, a novel histamine-releasing peptide of the Australian ant, Myrmecia pilosula (Jack Jumper Ant)', Archives of Biochemistry and Biophysics, vol. 477, no. 2, pp. 411-416. 29 29
2008	Wiese, MD, Milne, RW, Davies, N, Chataway, T, Brown, S & Heddle, R 2008, 'Myrmecia pilosula (Jack Jumper) ant venom: Validation of a procedure to standardise an allergy vaccine', Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 1, pp. 58-65. 13 11

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Australian National University	AUSTRALIA
Baker Heart and Diabetes Institute	AUSTRALIA
Beker Pharmaceuticals General Business Plc	ETHIOPIA
Bond University	AUSTRALIA
Bristol-Myers Squibb, US	AUSTRALIA
Centre for Eye Research Australia Ltd	AUSTRALIA
Centre for Translational Physiology	NEW ZEALAND
Concord Hospital	UNITED STATES
Dhhs - Ambulance Tasmania	AUSTRALIA
Duke University	UNITED STATES
Flinders Centre for Innovation in Cancer	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Greenslopes Private Hospital	AUSTRALIA
Jimma University	ETHIOPIA
Karolinska Institute	SWEDEN
King Saud University	SAUDI ARABIA
Macquarie University	AUSTRALIA
Mahidol University	THAILAND
Modbury Hospital	AUSTRALIA
Monash Medical Centre	AUSTRALIA
Monash University	AUSTRALIA
Murdoch University	AUSTRALIA
National Institute of Advanced Industrial Science and Technology	JAPAN
Princess Alexandra Hospital	AUSTRALIA
Private Individual	AUSTRALIA
Projections Research	UNITED STATES
Queen Elizabeth Hospital	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Repatriation General Hospital	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Hobart Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Shandong First Medical University	CHINA
Shandong University	CHINA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
Stockholm University	SWEDEN
Suwabus Bessouchi	JAPAN
The Alfred Hospital	AUSTRALIA
The Hospital for Sick Children	CANADA
Tokushima Bunri University	JAPAN
Univeristy of Toronto	CANADA
University of Adelaide	AUSTRALIA
University of Calgary	CANADA
University of Canberra	AUSTRALIA
University of Manchester	UNITED KINGDOM
University of Otago	NEW ZEALAND
University of Sheffield	UNITED KINGDOM
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Tasmania	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Toronto	CANADA
University of Western Australia	AUSTRALIA
University of Western Ontario	CANADA
University of Wollongong	AUSTRALIA
Watkins Medical Centre	AUSTRALIA
Westmead Hospital	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Member Australian Society of Clinical Immunology and Allergy (ASCIA)	2017
Member Australasian Pharmaceutical Science Association (APSA)	2017

Teaching & student supervision

Highlights

My primary areas of interest in teaching are oncology, rheumatology and clinical immunology. I enjoy interacting with students in small group teaching activities.

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
A computational approach to improve the prediction of fraction unbound to enhance pharmacokinetic (PK) and biopharmaceutic models	Current
Assessment of adherence and assessing drug concentration effect relationships in patients with rheumatoid arthritis and scleroderma.	Current
Born too soon: Impact on ability to metabolise drugs	Current
Comparison of different methods to assess adherence to weekly methotrexate and hydroxychloroquine	Current
Detecting biomarkers of fetal cardiac damage	Current
Developing strategies to promote the use of treat to target strategies with conventional synthetic disease modifying anti-rheumatic drugs in patients with early rheumatoid arthritis	Current
Development of ex vivo models to predict the efficacy of disease modifying agents in rheumatoid arthritis	Current
Disease-modifying anti-rheumatic drug therapy in rheumatoid arthritis patients: optimizing therapy and risk prediction	Current
Emerging role of pharmacist in preadmission clinics in prevention of postoperative delirium	Current
How low can you go? Effect of less oxygen and glucose in the womb on CYP function	Current
Novel methods of analysis and pharmacokinetics of viper venom components in human plasma	Current
Population variability of the omega-3 index and its relevance to chronic inflammatory disease states	Current
Prevention of cancer therapy induced side effects	Current
Using MRI to understand brain development in the fetus	Current
Why are small babies at risk of hypertension in adulthood? The role of oxygen and glucose in utero on blood pressure regulation	Current
Assessing patterns and appropriateness of prescription of medications in elderly patients admitted to South Australian Hospitals	Completed
Development and feasibility of a patient-centred deprescribing process	Completed
Fetal and maternal drug metabolism in complicated pregnancies	Completed
Individualisation of leflunomide dosing in rheumatoid arthritis patients	Completed
Interaction between a suboptimal intrauterine environment and maternal drug use on drug metabolism in the offspring	Completed
Investigating pharmacometric approaches to individualised medicine in autoimmune diseases	Completed
Liquid chromatography-tandem mass spectrometry-based bioanalysis to assess toxicological and therapeutic aspects in human disease conditions	Completed
Opioid prescribing in older patients; pharmacoepidemiology and pharmacokinetics	Completed
The role of adherence of physician to treatment strategies and patient to medications in rheumatoid arthritis	Completed
The role of haptenation in penicillin and cephalosporin allergy	Completed

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Associate Professor Michael Wiese

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Member

Member

Teaching & student supervision

Highlights

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

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