Dr Mitchell Lock

Research Fellow UniSA Clinical & Health Sciences

City West Campus (HB5-26)
tel +61 8 830 20200

email Mitchell.Lock@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Medical Physiology
Biological Sciences
Medical and Health Sciences
Physiology
Biochemistry and Cell Biology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2023	Lock, MC, Botting, KJ, Allison, BJ, Niu, Y, Ford, SG, Murphy, MP, Orgeig, S, Giussani, DA & Morrison, JL 2023, 'MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy', The Journal of Physiology, vol. 601, no. 16, pp. 3647-3665. Open access 8 8 2
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Brooks, DA, Seed, M, Selvanayagam, JB & Morrison, JL 2020, 'Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts', Frontiers in Physiology, vol. 11, article no. 614, pp. 1-21. Open access 8 8 4
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Doug, AB, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M & Morrison, JL 2020, 'Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart', Physiological Genomics, vol. 52, no. 3, pp. 143-159. Open access 5 4 3
2019	Lock, MC, Darby, JR, Soo, JY, Brooks, DA, Perumal, SR, Selvanayagam, JB, Seed, M, MacGowan, CK, Porrello, ER, Tellam, RL & Morrison, JL 2019, 'Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period', Frontiers in Physiology, vol. 10, article no. 208, pp. 1-24. Open access 23 23 4
2018	Lock, MC, Tellam, RL, Botting, KJ, Wang, KC, Selvanayagam, JB, Brooks, DA, Seed, M & Morrison, JL 2018, 'The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults', The Journal of Physiology, vol. 596, no. 23, pp. 5625-5640. Open access 41 35 3

Journal Articles

Year	Output
2025	Amanollahi, R, Holman, SL, Bertossa, MR, Meakin, AS, Thornburg, KL, McMillen, IC, Wiese, MD, Lock, MC & Morrison, JL 2025, 'Ontogeny of Fetal Cardiometabolic pathways: the potential role of Cortisol and Thyroid Hormones in driving the transition from Preterm to Near-Term Heart development in Sheep', Journal of Cardiovascular Development and Disease, vol. 12, no. 2, article no. 36, pp. 1-21. Open access
2025	Roff, AJ, Davies, AN, Clifton, VL, Stark, MJ, Tai, A, Robinson, JL, Hammond, SJ, Darby, JR, Meakin, AS, Lock, MC, Wiese, MD, Sharkey, DJ, Bischof, RJ, Morrison, JL & Gatford, KL 2025, 'Pregnancy does not affect progression of mild experimental asthma in sheep', The Journal of Physiology, vol. 603, no. 5, pp. 1241-1261. Open access
2024	Cho, SK, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Williams, GK, Macgowan, CK, Seed, M & Morrison, JL 2024, 'Late-gestation maternal undernutrition induces circulatory redistribution while preserving uteroplacental function independent of fetal glycaemic state', The Journal of Physiology, vol. 602, no. 24, pp. 7065-7083. 1
2024	Lock, MC, Patey, O V, Smith, KL, Niu, Y, Jaggs, B, Trafford, AW, Giussani, DA & Galli, GL 2024, 'Maladaptive cardiomyocyte calcium handling in adult offspring of hypoxic pregnancy: protection by antenatal maternal melatonin', The Journal of Physiology, vol. 602, no. 24, pp. 6683-6703. Open access 1 1 3
2024	Zhang, S, Lock, MC, Tie, M, McMillen, IC, Botting, KJ & Morrison, JL 2024, 'Cardiac programming in the placentally restricted sheep fetus in early gestation', The Journal of Physiology, vol. 602, no. 15, pp. 3815-3832. Open access 1 1
2023	Lock, MC, Botting, KJ, Allison, BJ, Niu, Y, Ford, SG, Murphy, MP, Orgeig, S, Giussani, DA & Morrison, JL 2023, 'MitoQ as an antenatal antioxidant treatment improves markers of lung maturation in healthy and hypoxic pregnancy', The Journal of Physiology, vol. 601, no. 16, pp. 3647-3665. Open access 8 8 2
2023	Padhee, M, Lock, MC, McMillen, IC, Zhang, S, Botting, KJ, Nyengaard, JR, MacLaughlin, SM, Kleemann, DO, Walker, SK, Kelly, JM, Rudiger, SR & Morrison, JL 2023, 'Sex-specific effects of in vitro culture and embryo transfer on cardiac growth in sheep offspring', Journal of Molecular and Cellular Cardiology Plus, vol. 5, article no. 100039, pp. 1-12. Open access 1 6
2023	Paramasivan, S, Morrison, JL, Lock, MC, Darby, JR, Barrero, RA, Mills, PC & Sadowski, P 2023, 'Automated proteomics workflows for high-throughput library generation and biomarker detection using data-independent acquisition', Journal of Proteome Research, vol. 22, no. 6, pp. 2018-2029. Open access 4 4
2022	Hansell, JA, Richter, HG, Camm, EJ, Herrera, EA, Blanco, CE, Villamor, E, Patey, O V, Lock, MC, Trafford, AW, Galli, GL & Giussani, DA 2022, 'Maternal melatonin: effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy', Journal of Pineal Research, vol. 72, no. 1, article no. e12766. Open access 24 22
2022	Ren, J, Lock, MC, Darby, JR, Orgeig, S, Holman, SL, Quinn, M, Seed, M, Muhlhausler, BS, Mcmillen, IC & Morrison, JL 2022, 'PPARγ activation in late gestation does not promote surfactant maturation in the fetal sheep lung', Journal of Developmental Origins of Health and Disease, vol. 12, no. 6, pp. 963-974. Open access 4 11 2
2021	Aujla, T, Darby, JR, Saini, BS, Lock, MC, Holman, SL, Bradshaw, EL, Perumal, SR, McInnes, SJ, Voelcker, NH, Wiese, MD, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of resveratrol-mediated increase in uterine artery blood flow on fetal haemodynamics, blood pressure and oxygenation in sheep', Experimental Physiology, vol. 106, no. 5, pp. 1166-1180. Open access 7 7 11
2021	McBride, GM, Meakin, AS, Soo, JY, Darby, JR, Varcoe, TJ, Bradshaw, EL, Lock, MC, Holman, SL, Saini, BS, Macgowan, CK, Seed, M, Berry, MJ, Wiese, MD & Morrison, JL 2021, 'Intrauterine growth restriction alters the activity of drug metabolising enzymes in the maternal-placental-fetal unit', Life Sciences, vol. 285, article no. 120016, pp. 1-9. Open access 15 14 7
2021	Ren, J, Darby, JR, Lock, MC, Holman, SL, Saini, BS, Bradshaw, EL, Orgeig, S, Perumal, SR, Macgowan, CK, Seed, M & Morrison, JL 2021, 'Impact of maternal late gestation undernutrition on surfactant maturation, pulmonary blood flow and oxygen delivery measured by magnetic resonance imaging in the sheep fetus', The Journal of Physiology, vol. 599, no. 20, pp. 4705-4724. Open access 9 6 10
2021	Saini, BS, Darby, JR, Marini, D, Portnoy, S, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Wald, RM, Windrim, R, MacGowan, CK, Kingdom, JC, Morrison, JL & Seed, M 2021, 'An MRI approach to assess placental function in healthy humans and sheep', The Journal of Physiology, vol. 599, no. 10, pp. 2573-2602. Open access 24 21 13
2021	Schrauben, EM, Darby, JR, Berry, MJ, Saini, BS, Quinn, M, Holman, SL, Bradshaw, EL, Lock, MC, Perumal, SR, Cho, SK, Aujla, T, Seed, M, Macgowan, CK & Morrison, JL 2021, 'Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets', Physiological Reports, vol. 9, no. 17, article no. e14999, pp. 1-15. Open access 4 4 8
2020	Cho, SK, Darby, JT, Saini, BS, Lock, MC, Holman, SL, Lim, JM, Perumal, SR, MacGowan, CK, Morrison, JL & Seed, M 2020, 'Feasibility of ventricular volumetry by cardiovascular MRI to assess cardiac function in the fetal sheep', The Journal of Physiology, vol. 598, no. 13, pp. 2557-2573. Open access 21 20 5
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Brooks, DA, Seed, M, Selvanayagam, JB & Morrison, JL 2020, 'Identification of novel miRNAs involved in cardiac repair following infarction in fetal and adolescent sheep hearts', Frontiers in Physiology, vol. 11, article no. 614, pp. 1-21. Open access 8 8 4
2020	Lock, MC, Tellam, RL, Darby, JR, Soo, JY, Doug, AB, Macgowan, CK, Selvanayagam, JB, Porrello, ER, Seed, M, Keller-Wood, M & Morrison, JL 2020, 'Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart', Physiological Genomics, vol. 52, no. 3, pp. 143-159. Open access 5 4 3
2020	Saini, BS, Darby, JR, Portnoy, S, Sun, L, van Amerom, J, Lock, MC, Soo, JY, Holman, SL, Perumal, SR, Kingdom, JC, Sled, JG, MacGowan, CK, Morrison, JL & Seed, M 2020, 'Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging', The Journal of Physiology, vol. 598, no. 15, pp. 3259-3281. Open access 52 48 10
2020	Schrauben, EM, Darby, JR, Saini, BS, Holman, SL, Lock, MC, Perumal, SR, Seed, M, Morrison, JL & Macgowan, CK 2020, 'Technique for comprehensive fetal hepatic blood flow assessment in sheep using 4D flow MRI', The Journal of Physiology, vol. 598, no. 17, pp. 3555-3567. Open access 9 9 5
2019	Clifton, VL, McDonald, M, Morrison, JL, Holman, SL, Lock, MC, Saif, Z, Meakin, A, Woolridge, AL, Gatford, KL, Wallace, MJ, Muhlhausler, BS, Bischof, RJ & Moss, TJ 2019, 'Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma', Placenta, vol. 83, pp. 33-36. Open access 12 12 6
2019	Darby, JR, Saini, BS, Soo, JY, Lock, MC, Holman, SL, Bradshaw, EL, McInnes, SJ, Voelcker, NH, Macgowan, CK, Seed, M, Wiese, MD & Morrison, JL 2019, 'Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth', The Journal of Physiology, vol. 597, no. 20, pp. 5063-5077. Open access 34 33 7
2019	Lock, MC, Darby, JR, Soo, JY, Brooks, DA, Perumal, SR, Selvanayagam, JB, Seed, M, MacGowan, CK, Porrello, ER, Tellam, RL & Morrison, JL 2019, 'Differential response to injury in fetal and adolescent sheep hearts in the immediate post-myocardial infarction period', Frontiers in Physiology, vol. 10, article no. 208, pp. 1-24. Open access 23 23 4
2019	Schrauben, EM, Saini, BS, Darby, JR, Soo, JY, Lock, MC, Stirrat, E, Stortz, G, Sled, JG, Morrison, JL, Seed, M & MacGowan, CK 2019, 'Fetal hemodynamics and cardiac streaming assessed by 4D flow cardiovascular magnetic resonance in fetal sheep', Journal of Cardiovascular Magnetic Resonance, vol. 21, article no. 8, pp. 1-11. Open access 48 50 9
2018	Lock, MC, Tellam, RL, Botting, KJ, Wang, KC, Selvanayagam, JB, Brooks, DA, Seed, M & Morrison, JL 2018, 'The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults', The Journal of Physiology, vol. 596, no. 23, pp. 5625-5640. Open access 41 35 3
2018	Morrison, JL, Berry, MJ, Botting, KJ, Darby, JR, Frasch, MG, Gatford, KL, Giussani, DA, Gray, CL, Harding, R, Herrera, EA, Kemp, MW, Lock, MC, McMillen, IC, Moss, TJ, Musk, GC, Oliver, MH, Regnault, TR, Roberts, CT, Soo, JY & Tellam, RL 2018, 'Improving pregnancy outcomes in humans through studies in sheep', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 315, no. 6, pp. 1123-1153. Open access 132 125 1
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of Biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. Open access 5 6 4
2018	Sorvina, A, Bader, C, Lock, MC, Brooks, DA, Morrison, JL & Plush, SE 2018, 'Label-free imaging of healthy and infarcted fetal sheep hearts by two-photon microscopy', Journal of Biophotonics, vol. 11, no. 1, article no. e201600296, pp. 1-8. Open access 6 4 3
2018	Sorvina, A, Bader, CA, Darby, JR, Lock, MC, Soo, JY, Johnson, IR, Caporale, C, Voelcker, NH, Stagni, S, Massi, M, Morrison, JL, Plush, SE & Brooks, DA 2018, 'Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex', Scientific Reports, vol. 8, no. 1, article no. 8191, pp. 1-8. Open access 32 28 9
2017	Duan, AQ, Lock, MC, Perumal, SR, Darby, JR, Soo, JY, Selvanayagam, JB, Macgowan, CK, Seed, M & Morrison, JL 2017, 'Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging', Journal of Cardiovascular Magnetic Resonance, vol. 19, no. 1, article no. 69, pp. 1-11. Open access 33 30 6
2017	Lock, MC, Botting, KJ, Tellam, RL, Brooks, D & Morrison, JL 2017, 'Adverse intrauterine environment and cardiac miRNA expression', International Journal of Molecular Sciences, vol. 18, no. 12, article no. 2628 pp. 1-19. Open access 24 23 2
2017	Lock, MC, McGillick, E V, Orgeig, S, McMillen, IC, Mühlhäusler, BS, Zhang, S & Morrison, JL 2017, 'Differential effects of late gestation maternal overnutrition on the regulation of surfactant maturation in fetal and postnatal life', The Journal of Physiology, vol. 595, no. 21, pp. 6635-6652. Open access 22 21 81
2017	McGillick, E V, Lock, MC, Orgeig, S & Morrison, J 2017, 'Maternal obesity mediated predisposition to respiratory complications at birth and in later life: understanding the implications of the obesogenic intrauterine environment', Paediatric Respiratory Reviews, vol. 21, pp. 11-18. Open access 47 40 6

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Aarhus University	DENMARK
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Federation University Australia	AUSTRALIA
Flinders University	AUSTRALIA
Maastricht University Medical Centre	NETHERLANDS
Monash University	AUSTRALIA
Oregon Health and Science University	UNITED STATES
Our Lady’s Children’s Hospital	IRELAND
Queensland University of Technology	AUSTRALIA
Royal Children's Hospital	UNITED KINGDOM
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
South Australian Research and Development Institute (SARDI)	AUSTRALIA
The Hospital for Sick Children	CANADA
Univeristy of Toronto	CANADA
Universidad Austral de Chile	CHILE
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Bologna	ITALY
University of Cambridge	UNITED KINGDOM
University of Chile	CHILE
University of Florida	UNITED STATES
University of Manchester	UNITED KINGDOM
University of Melbourne	AUSTRALIA
University of Ontario	CANADA
University of Otago	NEW ZEALAND
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Toronto	CANADA
University of Washington, Seattle	UNITED STATES
University of Western Australia	AUSTRALIA
Women and Children's Health Research Institute	CANADA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
622-Predicting fetal growth early in pregnancy with non-invasive MRI: Validation in a preclinical model with a focus on the lung	Current
Impact of glucocorticoids on heart development	Current
Impact of lifelong maternal Western diet on offspring cardiometabolic health	Current

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Dr Mitchell Lock

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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