Dr Nirmal Robinson

Senior Research Fellow: Cellular-Stress and Immune Response Centre for Cancer Biology

City West Campus (HB11-35)
tel +61 8 830 27949

email Nirmal.Robinson@unisa.edu.au

Research Degree Supervisor

About me

Dr Nirmal Robinson received his Ph.D in 2007 from the University of Bonn, Germany before conducting his postdoctoral research at the National Research Council of Canada, Ottawa. During this time, he deciphered the role of type-I interferons in regulating necroptotic cell death. He received the DFG-CECAD Fellowship in 2012 and joined as an independent Group Leader at the CECAD Research Centre at the University of Cologne. His research interests lie in understanding the molecular mechanisms that link metabolism and cellular stress responses in cancer and inflammation. Since the beginning of 2018 he is leading the Cellular Stress and Immune Signalling Lab at the Centre for Cancer Biology, University of South Australia. He also holds an... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Medical and Health Sciences
Biological Sciences
Immunology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2022	Chipurupalli, S, Desiderio, V & Robinson, N 2022, 'Analysis of ER-Phagy in cancer drug resistance', in Baiocchi, M (ed.), Cancer Drug Resistance, Humana Press, US, vol. 2535, ch. 16, pp. 211-220. 1
2022	Chipurupalli, S, Kumari, S, Desiderio, V & Robinson, N 2022, 'Hypoxia-induced stress responses in cancer and cancer stem cells', in Sajal Chakraborti, Bimal K Ray & Susanta Roychoudhury (eds), Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, Springer, Singapore, ch. 107, vol. 3, pp. 1829-1843.

Journal Articles

Year	Output
2023	Logesh, R, Prasad, SR, Chipurupalli, S, Robinson, N & Mohankumar, SK 2023, 'Natural tyrosinase enzyme inhibitors: a path from melanin to melanoma and its reported pharmacological activities', Biochimica et Biophysica Acta: Reviews on Cancer, vol. 1878, no. 6, article no. 188968, pp. 1-27.
2023	Thomas, D, Wu, M, Nakauchi, Y, Zheng, M, Thompson-Peach, CA, Lim, K, Landberg, N, Koehnke, T, Robinson, N, Kaur, S, Kutyna, M, Stafford, M, Hiwase, D, Reinisch, A, Peltz, G & Majeti, R 2023, 'Dysregulated lipid synthesis by oncogenic IDH1 mutation is a targetable synthetic lethal vulnerability', Cancer Discovery, vol. 13, no. 2, pp. 496-512. Open access 4 2 106
2022	Bassal, MA, Samaraweera, SE, Lim, K, Bernard, BA, Bailey, S, Toubia, J, Nguyen, T, Maung, KZY, Casolari, DA, Iarossi, DG, Powell, J, Pitson, S, Brown, AL, Robinson, N, Ross, DM, Gonda, TJ & D'Andrea, RJ and 10 other authors 2022, 'Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia', Nature Communications, vol. 13, article no. 2614, pp. 1-12. Open access 5 6 9
2022	Chipurupalli, S, Ganesan, R, Martini, G, Mele, L, Reggio, A, Esposito, M, Kannan, E, Namasivayam, V, Grumati, P, Desiderio, V & Robinson, N 2022, 'Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress', Cell Death and Disease, vol. 13, no. 4, pp. 1-13. Open access 13 8 6
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 11 6 78
2021	Chipurupalli, S, Samavedam, U & Robinson, N 2021, 'Crosstalk between ER stress, autophagy and inflammation', Frontiers in Medicine, vol. 8, article no. 758311, pp. 1-9. Open access 43 36 3
2021	Gutiérrez, S, Fischer, J, Ganesan, R, Judith, NH, Cildir, G, Wolke, M, Pessia, A, Frommolt, P, Desiderio, V, Velagapudi, V & Robinson, N 2021, 'Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense', PLoS Pathogens, vol. 17, no. 9, article no. e1009943. Open access 4 2 9
2020	Barbieri, A, Robinson, N, Palma, G, Maurea, N, Desiderio, V & Botti, G 2020, 'Can beta-2-adrenergic pathway be a new target to combat SARS-CoV-2 hyperinflammatory syndrome?-Lessons learned from cancer', Frontiers in Immunology, vol. 11, article no. 588724, pp. 1-6. Open access 31 26 55
2020	Chipurupalli, S, Ganesan, R, Dhanabal, S, Kumar, MS & Robinson, N 2020, 'Pharmacological STING activation is a potential alternative to overcome drug-resistance in melanoma', Frontiers in Oncology, vol. 10, article no. 758, pp. 1-9. Open access 13 14 2
2020	Hos, NJ, Fischer, J, Hos, D, Hejazi, Z, Calabrese, C, Ganesan, R, Murthy, AM, Rybniker, J, Kumar, S, Krönke, M & Robinson, N 2020, 'TRIM21 Is targeted for chaperone-mediated autophagy during salmonella typhimurium infection', Journal of Immunology, vol. 205, no. 9, pp. 2456-2467. Open access 14 12 5
2020	Kew, C, Huang, W, Fischer, J, Ganesan, R, Robinson, N & Antebi, A 2020, 'Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60', eLife, vol. 9, article no. e57591, pp. 1-23. Open access 9 7 82
2020	Mele, L, del Vecchio, V, Liccardo, D, Prisco, C, Schwerdtfeger, M, Robinson, N, Desiderio, V, Tirino, V, Papaccio, G & La Noce, M 2020, 'The role of autophagy in resistance to targeted therapies', Cancer Treatment Reviews, vol. 88, article no. 102043, pp. 1-14. Open access 76 66 3
2020	Murthy, AM, Robinson, N & Kumar, S 2020, 'Crosstalk between cGAS-STING signaling and cell death', Cell Death and Differentiation, vol. 27, no. 11, pp. 2989-3003. 55 42 12
2019	Chipurupalli, S, Kannan, E, Tergaonkar, V, D'Andrea, R & Robinson, N 2019, 'Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer', International Journal of Molecular Sciences, vol. 20, no. 3, pp. 1-17. Open access 67 62 2
2019	Cildir, G, Toubia, J, Yip, KH, Zhou, M, Pant, H, Hissaria, P, Zhang, J, Hong, W, Robinson, N, Grimbaldeston, MA, Lopez, AF & Tergaonkar, V 2019, 'Genome-wide analyses of chromatin state in human mast cells reveal molecular drivers and mediators of allergic and inflammatory diseases', Immunity, vol. 51, no. 5, pp. 949-965.e6. Open access 32 30 12
2019	Fischer, J, Gutièrrez, S, Ganesan, R, Calabrese, C, Ranjan, R, Cildir, G, Hos, NJ, Rybniker, J, Wolke, M, Fries, JW, Tergaonkar, V, Plum, G, Antebi, A & Robinson, N 2019, 'Leptin signaling impairs macrophage defenses against Salmonella Typhimurium', Proceedings of the National Academy of Sciences of USA, vol. 116, no. 33, pp. 16551-16560. Open access 13 14 8
2019	Robinson, N, Ganesan, R, Hegedus, C, Kovács, K, Kufer, TA & Virág, L 2019, 'Programmed necrotic cell death of macrophages: focus on pyroptosis, necroptosis, and parthanatos', Redox Biology, vol. 26, article no. 101239, pp. 1-8. Open access 179 157 7
2018	Robinson, N 2018, 'Salmonella Typhimurium infection: type I interferons integrate cellular networks to disintegrate macrophages', Cell Stress, vol. 2, no. 2, pp. 37-39. Open access 4 3
2018	Tiku, V, Kew, C, Mehrotra, P, Ganesan, R, Robinson, N & Antebi, A 2018, 'Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance', Nature Communications, vol. 9, article no. 3607, pp. 1-10. Open access 32 31 48
2017	Ganesan, R, Hos, NJ, Gutierrez, S, Fischer, J, Stepek, JM, Daglidu, E, Krönke, M & Robinson, N 2017, 'Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy', PLoS Pathogens, vol. 13, no. 2, article no. e1006227, pp. 1-22. Open access 85 77 81
2017	Gutiérrez, S, Wolke, M, Plum, G & Robinson, N 2017, 'Isolation of Salmonella typhimurium-containing phagosomes from macrophages', Journal of Visualized Experiments, no. 128, article number: e56514, pp. 1-11. Open access 3 3 1
2017	Hos, NJ, Ganesan, R, Gutiérrez, S, Hos, D, Klimek, J, Abdullah, Z, Krönke, M & Robinson, N 2017, 'Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses', The Journal of Cell Biology, vol. 216, no. 12, pp. 4107-4121. Open access 40 38 9
2015	Fischer, J, Jung, N, Robinson, N & Lehmann, C 2015, 'Sex differences in immune responses to infectious diseases', Infection, vol. 43, no. 4, pp. 399-403. 113 103 40
2014	Persa, O-D, Jazmati, N, Robinson, N, Wolke, M, Kremer, K, Schweer, K, Plum, G & Schlaak, M 2014, 'A pregnant woman with chronic meningococcaemia from Neisseria meningitidis with lpxL1-mutations', The Lancet, vol. 384, no. 9957, pp. 1900-1900. 5 3 40
2013	Nguyen, T, Robinson, N, Allison, S, Coombes, B, Sad, S & Krishnan, L 2013, 'IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium', Placenta, vol. 34, no. 9, pp. 765-774. Open access 20 18 1
2012	Robinson, N, McComb, S, Mulligan, R, Dudani, R, Krishnan, L & Sad, S 2012, 'Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium', Nature Immunology, vol. 13, no. 10, pp. 954-962. Open access 330 313
2010	Chattopadhyay, A, Robinson, N, Sandhu, JK, Finlay, BB, Sad, S & Krishnan, L 2010, 'Salmonella enterica Serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease', Infection and Immunity, vol. 78, no. 5, pp. 2292-2301. Open access 33 31
2010	Rybniker, J, Nowag, A, Van Gumpel, E, Nissen, N, Robinson, N, Plum, G & Hartmann, P 2010, 'Insights into the function of the WhiB‐like protein of mycobacteriophage TM4: a transcriptional inhibitor of WhiB2', Molecular Microbiology, vol. 77, no. 3, pp. 642-657. Open access 70 65
2009	Albaghdadi, H, Robinson, N, Finlay, B, Krishnan, L & Sad, S 2009, 'Selectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response', Journal of Immunology, vol. 183, no. 6, pp. 3778-3787. Open access 35 33
2008	Robinson, N, Kolter, T, Wolke, M, Rybniker, J, Hartmann, P & Plum, G 2008, 'Mycobacterial phenolic glycolipid inhibits phagosome maturation and subverts the pro‐inflammatory cytokine response', Traffic, vol. 9, no. 11, pp. 1936-1947. Open access 38 35
2008	Rybniker, J, Plum, G, Robinson, N, Small, PL & Hartmann, P 2008, 'Identification of three cytotoxic early proteins of mycobacteriophage L5 leading to growth inhibition in Mycobacterium smegmatis', Microbiology, vol. 154, no. 8, pp. 2304-2314. Open access 24 21

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
A-Star, Institute of Molecular and Cell Biology	SINGAPORE
Genentech, Inc.	UNITED STATES
Harvard University	UNITED STATES
Institute for Molecular Medicine Finland	FINLAND
Istituto Nazionale Tumori IRCCS	ITALY
Jss Academy of Higher Education & Research	INDIA
JSS College of Pharmacy	INDIA
Max Planck Institute for Biology of Ageing	GERMANY
McMaster University	CANADA
MTA-DE Cell Biology and Signaling Research Group	HUNGARY
National Research Council Institute for Biological Sciences	CANADA
National Research Council of Canada	CANADA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Stanford University	UNITED STATES
Swansea University	UNITED KINGDOM
Telethon Institute Of Genetics And Medicine	ITALY
University of Adelaide	AUSTRALIA
University of Bonn	GERMANY
University of British Columbia	CANADA
University of Campania	ITALY
University Of Campania Luigi Vanvitelli	ITALY
University of Cincinnati Medical Center	UNITED STATES
University of Cologne	GERMANY
University of Debrecen	HUNGARY
University of Hohenheim	GERMANY
University of Ottawa	CANADA
University of Queensland	AUSTRALIA
University of Regensburg	GERMANY
University of South Australia	AUSTRALIA
University of Tennessee	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
European Science Foundation's College of Expert Reviewers European Science Foundation	2023
European Science Foundation's College of Expert Reviewers European Science Foundation	2022
Invited Presentation Institute for Biochemistry, Goethe University	2016
Invited Presentation JSS College of Pharmacy	2016
Invited Presentation Biodesign Institute, Arizona State University	2015
Invited Presentation Biology of Sirtuins, Keystone Symposium, Santa Fe, USA	2015
Invited Speaker Leibniz Institute on Ageing Annual meeting	2015
Invited Presentation Canadian Society of Immunology	2014
Invited Presentation The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD) Graduate School	2012
Invited Presentation The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD) Annual Meeting	2011
Invited Presentation Canadian Society of Immunology	2010
Invited Presentation Center for Molecular Medicine	2010
Invited Presentation International Congress of Immunology	2010
Invited Presentation Unilever	2010
Invited Presentation at Young Investigators Meet Broad Institute	2010
Researcher of the year Institute for Biological Sciences NRC	2009

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
109455 - Examining the impact of environmental stressors and mutant microenvironment on disease development in models of inherited predisposition to haematological malignancies	Current
Investigating the role of CD47 in cancer to develop novel antitumor treatment strategies	Current

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Dr Nirmal Robinson

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

European Science Foundation's College of Expert Reviewers

European Science Foundation's College of Expert Reviewers

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation

Invited Speaker

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation

Invited Presentation at Young Investigators Meet

Researcher of the year

Teaching & student supervision

Courses and programs

Research degree supervision

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