Mr Paul Moretti

Research Assistant Centre for Cancer Biology

City West Campus (HB10-25)
tel +61 8 830 27868

email Paul.Moretti@unisa.edu.au

Research

Research focus

Biological Sciences
Medical and Health Sciences
Biochemistry and Cell Biology
Chemical Sciences
Clinical Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Lazniewska, J, Li, KL, Johnson, IR, Sorvina, A, Logan, JM, Martini, C, Moore, C, Ung, BS, Karageorgos, L, Hickey, SM, Prabhakaran, S, Heatlie, JK, Brooks, RD, Huzzell, C, Warnock, N I, Moretti, P, Pitson, SM & Brooks, DA and 10 other authors 2023, 'Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression', Scientific Reports, vol. 13, no. 1, article no. 13489, pp. 1-18. Open access
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 11 6 78
2022	Pitman, MR, Lewis, AC, Davies, LT, Moretti, PA, Anderson, D, Creek, DJ, Powell, JA & Pitson, SM 2022, 'The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism', Scientific Reports, vol. 12, no. 1, article no.454, pp. 1-12. Open access 4 3 90
2022	Tvorogov, D, Thompson-Peach, CA, Foßelteder, J, Dottore, M, Stomski, F, Onnesha, SA, Lim, K, Moretti, PA, Pitson, SM, Ross, DM, Reinisch, A, Thomas, D & Lopez, AF 2022, 'Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody', EMBO Reports, vol. 23, no. 4, article no. e52904. Open access 8 6 15
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 16 15 5
2019	Powell, JA, Pitman, MR, Zebol, JR, Moretti, PA, Neubauer, HA, Davies, LT, Lewis, AC, Dagley, LF, Webb, A I, Costabile, M & Pitson, SM 2019, 'Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1', Biochemical Journal, vol. 476, no. 21, pp. 3211-3226. Open access 9 9
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 61 56 85
2017	Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616. Open access 35 34 7
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. Open access 27 26
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 26 23 8
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 49 47
2015	Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774. Open access 28 22 25
2015	Parham, KA, Zebol, JR, Tooley, KL, Sun, WY, Moldenhauer, LM, Cockshell, MP, Gliddon, BL, Moretti, PA, Tigyi, G, Pitson, SM & Bonder, CS 2015, 'Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis', The FASEB Journal, vol. 29, no. 9, pp. 3638-3653. Open access 64 62 1
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 56 52
2014	Pham, D, Powell, J, Gliddon, B, Moretti, P, Tsykin, A, Van Der Hoek, M, Kenyon, R, Goodall, G & Pitson, S 2014, 'Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1', Oncogene, vol. 33, no. 48, pp. 5559-5568. Open access 24 23
2011	Barrett, JM, Parham, KA, Pippal, JB, Cockshell, MP, Moretti, PA, Brice, SL, Pitson, S & Bonder, C 2011, 'Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells', Microcirculation, vol. 18 no. 7, pp. 583-597. 10 10
2011	Leclercq, T, Moretti, PAB & Pitson, SM 2011, 'Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis', Oncogene, vol. 30, no. 3, pp. 372-378. Open access 44 35
2011	Pitman, MR, Barr, RK, Gliddon, BL, Magarey, AM, Moretti, PA & Pitson, SM 2011, 'A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1', The International Journal of Biochemistry and Cell Biology, vol. 43, no. 3, pp. 342-347. 22 18
2010	Jarman, KE, Moretti, PA, Zebol, JR & Pitson, SM 2010, 'Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1', Journal of Biological Chemistry, vol. 285 no. 1, pp. 483-492. 122
2009	Zebol, JR, Hewitt, NM, Moretti, PA, Lynn, HE, Lake, JA, Li, P, Vadas, MA, Wattenberg, BW & Pitson, SM 2009, 'The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1', The International Journal of Biochemistry and Cell Biology, vol. 41 no. 4, pp. 822-827. Open access 18 16
2008	Barr, R, Lynn, H, Moretti, PAB, Khew-Goodall, Y & Pitson, SM 2008, 'Deactivation of sphingosine kinase 1 by protein phosphatase 2A', Journal of Biological Chemistry, vol. 283, no. 50, pp. 34994-35002. Open access 49 42
2008	Leclercq, T, Moretti, PAB, Vadas, M & Pitson, SM 2008, 'Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity', Journal of Biological Chemistry, vol. 283, no. 15, pp. 9606-9614. Open access 45 43
2008	Pham, D, Moretti, PAB, Goodall, G & Pitson, SM 2008, 'Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements', Biotechniques: The Journal of Laboratory Technology for Bioresearch, vol. 45 no. 2, pp. 155-162. 20

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Institute of Medical and Veterinary Science	AUSTRALIA
La Trobe University	AUSTRALIA
Medical University of Graz	AUSTRIA
Monash University	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
SA Pathology	AUSTRALIA
Stanford University	UNITED STATES
The Kinghorn Cancer Centre	AUSTRALIA
University of Adelaide	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of South Australia	AUSTRALIA
University of Tennessee	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

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Mr Paul Moretti

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

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