A/Prof Gregory leads the Gene Regulation in Cancer laboratory within the Centre for Cancer Biology. As an NHMRC Peter Doherty Training fellowship he made seminal discoveries about the functions of microRNAs in epithelial-mesenchymal transition (EMT), a hallmark feature of cancer progression (Nature Cell Biol 2008, >4000 cites, Cancer Research 2008, >1000 cites). As a National Breast Cancer Foundation Early Career fellow, he uncovered key mechanisms through which microRNAs control EMT and tumour metastasis (published in Mol Biol Cell 2011, >500 cites and Oncogene). As a Cancer Council mid career fellow, he started an independent lab investigating gene regulatory mechanisms controlling breast... Read more
About me
A/Prof Gregory leads the Gene Regulation in Cancer laboratory within the Centre for Cancer Biology. As an NHMRC Peter Doherty Training fellowship he made seminal discoveries about the functions of microRNAs in epithelial-mesenchymal transition (EMT), a hallmark feature of cancer progression (Nature Cell Biol 2008, >4000 cites, Cancer Research 2008, >1000 cites). As a National Breast Cancer Foundation Early Career fellow, he uncovered key mechanisms through which microRNAs control EMT and tumour metastasis (published in Mol Biol Cell 2011, >500 cites and Oncogene). As a Cancer Council mid career fellow, he started an independent lab investigating gene regulatory mechanisms controlling breast and prostate tumour progression, with a particular focus on alternative splicing (Cell 2015, >1500 cites and EMBO J 2018). A/Prof Gregory held a Beat Cancer Principal Research Fellow from 2019-2021 and is Associate Editor of the journal Oncogenesis.
About me
Secretary of The International Epithelial Mesenchymal Transition Association (TEMTIA)
NHMRC GRP (2013-)
Cancer Australia GRP (2014-)
About me
Date | Title |
---|---|
04/01/2019 |
Sydney Morning Herald, https://www.smh.com.au/national/discovery-could-have-deadly-prostate-cancer-quaking-20190103-p50pfw.html |
04/01/2019 |
SBS News, https://www.sbs.com.au/news/a-breakthrough-and-funding-pledge-for-one-of-australia-s-most-common-cancers |
04/01/2019 |
Department of Health, http://www.health.gov.au/internet/ministers/publishing.nsf/Content/health-mediarel-yr2019-hunt001.htm |
03/09/2018 |
The Hospital Research Foundation, https://www.hospitalresearch.com.au/new-piece-prostate-cancer-puzzle/ |
About me
Doctor of Philosophy The Flinders University of South Australia
Bachelor of Biotechnology (Honours) The Flinders University of South Australia
Beat Cancer Principal Research Fellow (2019-present)
Head, Gene Regulation in Cancer Laboratory, Centre for Cancer Biology (2015-present)
Cancer Council SA Mid Career fellowship (2013-2015)
National Breast Cancer Foundation Early Career fellowship (2009-2012)
NHMRC Peter Doherty Training Fellow (2005-2008)
Tumour metastasis is the major cause of cancer related death in solid tumours such as the breast and prostate. My laboratory conducts research into understanding how tumour cells gain aggressive properties and spread throughout the body. We focus on identifying the importance of the molecular changes that occur as cells transition to aggressive forms, specifically on RNA changes involving microRNAs and alternative splicing (including circular RNAs).
Research
Excludes commercial-in-confidence projects.
Characterising an RNA splicing pathway driving prostate cancer metastasis and therapy resistance, NHMRC - Project Grant, 01/01/2019 - 31/12/2022
Use of a new molecule (miR-342) to discover important pathways to treat advanced breast cancer, NBCF - Investigator Initiated Research Scheme, 01/01/2018 - 01/07/2021
Characterising novel alternative splicing networks that promote tumour cell plasticity, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Targeting microRNA-driven mesenchymal to epithelial transition to suppress prostate cancer metastasis, NHMRC - Project Grant, 01/01/2015 - 31/12/2017
Role of the microRNA target Quaking in alternative splicing during EMT and cancer progression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
Discovery of optimal targets to better diagnose and treat metastatic cancer. Beat Cancer Principal Research Fellowship (2019-2021)
Characterising an RNA splicing pathway driving prostate cancer metastasis and therapy resistance. CIA NHMRC Project Grant (2019-2021)
New regulators of advanced prostate cancer. CIA The Hospital Research Foundation (2018)
Research
Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus
Open access indicates that an output is open access.
Year | Output |
---|---|
2018 |
Open access
13
12
1
|
2018 |
Open access
58
58
15
|
2015 |
Open access
1374
1356
21
|
2011 |
Open access
454
426
|
2008 |
3199
3020
|
Year | Output |
---|---|
2022 |
Open access
1
18
|
2022 |
Open access
4
4
1
|
2022 |
Open access
8
7
2
|
2021 |
Open access
4
4
|
2021 |
Open access
19
18
124
|
2020 |
Open access
7
7
9
|
2019 |
3
3
|
2019 |
Open access
5
4
5
|
2019 |
10
11
1
|
2018 |
Open access
59
54
34
|
2018 |
Open access
13
12
1
|
2018 |
Open access
58
58
15
|
2017 |
Open access
83
83
61
|
2017 |
Open access
84
85
11
|
2017 |
Open access
49
51
8
|
2015 |
Open access
1374
1356
21
|
2014 |
Open access
116
115
13
|
2014 |
21
20
2
|
2014 |
Open access
55
50
|
2014 |
98
91
|
2014 |
Open access
88
79
27
|
2014 |
29
28
|
2013 |
Open access
165
149
2
|
2013 |
Open access
133
124
4
|
2012 |
Open access
130
127
|
2012 |
Open access
3
3
|
2011 |
Open access
454
426
|
2011 |
Open access
120
117
|
2011 |
Open access
170
156
|
2010 |
Open access
27
26
|
2009 |
106
94
|
2009 |
Open access
408
391
|
2008 |
Open access
882
833
|
2008 |
3199
3020
|
2008 |
Open access
423
392
|
2008 |
Open access
73
69
|
Gomez GA, Woodcock JM, Tergaonkar V, GREGORY PA (2018) Meeting Report: The 8th Barossa Meeting-Cell Signaling in Cancer Medicine in the Barossa Valley, Australia. CELL DEATH DIS. 2018 Feb 15;9(3):284.
Research
Tumour metastasis is the major cause of cancer related death in solid tumours such as the breast and prostate. My laboratory conducts research into understanding how tumour cells gain aggressive properties and spread throughout the body. We focus on identifying the importance of the molecular changes that occur as cells transition to aggressive forms, specifically on RNA changes involving microRNAs and alternative splicing (including circular RNAs).
Runner-up for the Inaugural Peter Sutherland Award (2019)
South Australian Young Tall Poppy Science Award (2011)
Hanson Institute New Basic Science Investigator Award (2009)
External engagement & recognition
Organisation | Country |
---|---|
Australian National University | AUSTRALIA |
Baylor College of Medicine | UNITED STATES |
Canberra Hospital | AUSTRALIA |
Cancer Council of South Australia | AUSTRALIA |
Cancer Council Victoria | AUSTRALIA |
Ecole Nationale Superieure de Chimie, de Biologie et de Physique de Bordeaux | FRANCE |
Flinders Medical Centre | AUSTRALIA |
Flinders University | AUSTRALIA |
Hanson Institute | AUSTRALIA |
Institute of Medical and Veterinary Science | AUSTRALIA |
Karolinska Institute | SWEDEN |
La Trobe University | AUSTRALIA |
Mahidol University | THAILAND |
McGill University | CANADA |
Monterrey Institute Of Technology And Higher Education | MEXICO |
Nagasaki University | JAPAN |
Olivia Newton-John Cancer Research Institute | AUSTRALIA |
Peter MacCallum Cancer Centre | AUSTRALIA |
Queensland University of Technology | AUSTRALIA |
Royal Brisbane and Women's Hospital | AUSTRALIA |
SA Pathology | AUSTRALIA |
St Vincent's Hospital | AUSTRALIA |
Stanford University | UNITED STATES |
The Australian Wine Research Institute | AUSTRALIA |
Translation Research Institute Australia | AUSTRALIA |
University of Adelaide | AUSTRALIA |
University of British Columbia | CANADA |
University of Canberra | AUSTRALIA |
University of Malaya | MALAYSIA |
University of Melbourne | AUSTRALIA |
University of Queensland | AUSTRALIA |
University of South Australia | AUSTRALIA |
University of Texas | UNITED STATES |
University of Texas MD Anderson Cancer Centre | UNITED STATES |
Walter & Eliza Hall Institute | AUSTRALIA |
Walter and Eliza Hall Institute of Medical Research | AUSTRALIA |
External engagement & recognition
Engagement/recognition | Year |
---|---|
Conference ConvenorThird Australia-India EMT meeting |
2019 |
Invited National Review Panel MemberNational Health and Medical Research Council (NHMRC) |
2019 |
Invited SpeakerGenetics Society of AustralAsia Conference |
2019 |
MemberSecretary of EMT International Association |
2019 |
Runner-up Peter Sutherland AwardPacRim Breast & Prostate Cancer Meeting |
2019 |
Invited LectureOlivia Newton John Cancer Research Institute |
2018 |
Invited National Review MemberCancer Australia Grant Review Panel |
2018 |
MemberSecretary of EMT International Association |
2018 |
Principal Research FellowshipBeat Cancer |
2018 |
Project GrantNational Health and Medical Research Council (NHMRC) |
2018 |
Co-supervisor of a PhD student at Adelaide UniversityThe University of Adelaide |
2017 |
MemberSecretary of EMT International Association |
2017 |
Co-supervisor of a PhD student at Adelaide UniversityThe University of Adelaide |
2016 |
Invited National Review Panel MemberNational Health and Medical Research Council (NHMRC) |
2016 |
MemberSecretary of EMT International Association |
2016 |
Project GrantNational Health and Medical Research Council (NHMRC) |
2016 |
Primary Supervisor of a PhD student at Adelaide UniversityThe University of Adelaide |
2014 |
Tall Poppy of the Year AwardAustralian Institute of Policy and Science |
2011 |
Teaching & student supervision
Supervisions from 2010 shown
Thesis title | Student status |
---|---|
A novel protein ZCCHC24 as a regulator of breast cancer cell plasticity and metastasis | Current |
Alternative splicing networks and their impact on the development of aggressive prostate cancer | Current |
Nuclear functions of microRNAs that control EMT in breast cancer | Current |
Targeting oncogenic signalling with custom RNA drugs | Current |
The role of RNA-binding proteins in epithelial-mesenchymal transition | Completed |