Associate Professor Philip Gregory

Associate Research Professor Centre for Cancer Biology

City West Campus (HB9-32)
tel +61 8 830 27829

email Philip.Gregory@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

A/Prof Gregory leads the Gene Regulation in Cancer laboratory within the Centre for Cancer Biology. As an NHMRC Peter Doherty Training fellowship he made seminal discoveries about the functions of microRNAs in epithelial-mesenchymal transition (EMT), a hallmark feature of cancer progression (Nature Cell Biol 2008, >4000 cites, Cancer Research 2008, >1000 cites). As a National Breast Cancer Foundation Early Career fellow, he uncovered key mechanisms through which microRNAs control EMT and tumour metastasis (published in Mol Biol Cell 2011, >500 cites and Oncogene). As a Cancer Council mid career fellow, he started an independent lab investigating gene regulatory mechanisms controlling breast... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

About me

In the media

Date	Title
04/01/2019	Sydney Morning Herald, https://www.smh.com.au/national/discovery-could-have-deadly-prostate-cancer-quaking-20190103-p50pfw.html
04/01/2019	SBS News, https://www.sbs.com.au/news/a-breakthrough-and-funding-pledge-for-one-of-australia-s-most-common-cancers
04/01/2019	Department of Health, http://www.health.gov.au/internet/ministers/publishing.nsf/Content/health-mediarel-yr2019-hunt001.htm
03/09/2018	The Hospital Research Foundation, https://www.hospitalresearch.com.au/new-piece-prostate-cancer-puzzle/

Research

Research focus

Biochemistry and Cell Biology
Biological Sciences
Medical and Health Sciences
Oncology and Carcinogenesis
Genetics

Highlights

Tumour metastasis is the major cause of cancer related death in solid tumours such as the breast and prostate. My laboratory conducts research into understanding how tumour cells gain aggressive properties and spread throughout the body. We focus on identifying the importance of the molecular changes that occur as cells transition to aggressive forms, specifically on RNA changes involving microRNAs and alternative splicing (including circular RNAs).

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2018	Neumann, DP, Goodall, GJ & Gregory, PA 2018, 'Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity', Seminars in Cell and Developmental Biology, vol. 75, pp. 50-60. Open access 13 12 1
2018	Pillman, KA, Phillips, CA, Roslan, S, Toubia, J, Dredge, BK, Bert, AG, Lumb, R, Neumann, DP, Li, X, Conn, SJ, Liu, D, Bracken, CP, Lawrence, DM, Schreiber, AW, Khew-Goodall, Y, Goodall, GJ & Gregory, PA and 4 other authors 2018, 'miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking', The EMBO Journal, vol. 37, no. 13, article no. e99016, pp. 1-20. Open access 58 58 15
2015	Conn, SJ, Pillman, KA, Toubia, J, Conn, VM, Salmanidis, M, Phillips, CA, Roslan, S, Schreiber, AW, Gregory, PA & Goodall, GJ 2015, 'The RNA binding protein quaking regulates formation of circRNAs', Cell, vol. 160, no. 6, pp. 1125-1134. Open access 1374 1356 21
2011	Gregory, PA, Bracken, CP, Smith, E, Bert, AG, Wright, JA, Roslan, S, Morris, M, Wyatt, L, Farshid, G, Lim, Y-Y, Lindeman, GJ, Shannon, MF, Drew, PA, Khew-Goodall, Y & Goodall, GJ 2011, 'An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition', Molecular Biology of the Cell, vol. 22, no. 10, pp. 1686-1698. Open access 454 426
2008	Gregory, PA, Bert, A, Paterson, E, Barry, S, Tsykin, A, Farshid, G, Vadas, M, Khew-Goodall, Y & Goodall, G 2008, 'The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1', Nature Cell Biology, vol. 10, no. 5, pp. 593-601. 3199 3020

Journal Articles

Year	Output
2022	Chi, LH, Cross, RS, Redvers, RP, Davis, M, Hediyeh-zadeh, S, Mathivanan, S, Samuel, M, Lucas, EC, Mouchemore, K, Gregory, PA, Johnstone, CN & Anderson, RL 2022, 'MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms', Oncogenesis, vol. 11, no. 1, article no. 38 pp. 1-12. Open access 1 18
2022	Neumann, DP, Goodall, GJ & Gregory, PA 2022, 'The Quaking RNA-binding proteins as regulators of cell differentiation', Wiley interdisciplinary reviews. RNA, vol. 13, no. 6, article no. e1724, pp. 1-19. Open access 4 4 1
2022	Tang, YH, Rockstroh, A, Sokolowski, KA, Lynam, L-R, Lehman, M, Thompson, EW, Gregory, PA, Nelson, CC, Volpert, M & Hollier, BG 2022, 'Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation', Breast Cancer Research, vol. 24, no. 1, article no. 8, pp. 1-17. Open access 8 7 2
2021	Chan, KM, Gleadle, JM, Gregory, PA, Phillips, CA, Safizadeh Shirazi, H, Whiteley, A, Li, J, Vasilev, K & Macgregor, M 2021, 'Selective microfluidic capture and detection of prostate cancer cells from urine without digital rectal examination', Cancers, vol.13, no. 21, article no. 5544. Open access 4 4
2021	Fernandes, RC, Toubia, J, Townley, S, Hanson, AR, Dredge, BK, Pillman, KA, Bert, AG, Gregory, PA, Goodall, GJ & Selth, LA and 12 other authors 2021, 'Post-transcriptional gene regulation by microRNA-194 promotes neuroendocrine transdifferentiation in prostate cancer', Cell Reports, vol. 34, no. 1, article no. 108585, pp. 1-24. Open access 19 18 124
2020	Saunders, K, Bert, AG, Dredge, BK, Toubia, J, Gregory, PA, Pillman, KA, Goodall, GJ & Bracken, CP 2020, 'Insufficiently complex unique-molecular identifiers (UMIs) distort small RNA sequencing', Scientific Reports, vol. 10, no. 1, pp. 1-9. Open access 7 7 9
2019	Gregory, PA 2019, 'The miR-200-Quaking axis functions in tumour angiogenesis', Oncogene, vol. 38, no. 41, pp. 6767-6769. 3 3
2019	Pillman, KA, Scheer, KG, Hackett-Jones, E, Saunders, K, Bert, AG, Toubia, J, Whitfield, HJ, Sapkota, S, Sourdin, L, Pham, H, Le, TD, Cursons, J, Davis, MJ, Gregory, PA, Goodall, GJ & Bracken, CP 2019, 'Extensive transcriptional responses are co-ordinated by microRNAs as revealed by Exon-Intron Split Analysis (EISA)', Nucleic Acids Research, vol. 47, no. 16, pp. 8606-8619. Open access 5 4 5
2019	Pinweha, P, Phillips, CA, Gregory, PA, Li, X, Chuayboonya, P, Mongkolsiri, P, Goodall, GJ & Jitrapakdee, S 2019, 'MicroRNA-143-3p targets pyruvate carboxylase expression and controls proliferation and migration of MDA-MB-231 cells', Archives of Biochemistry and Biophysics, vol. 677, article no. 108169, pp. 1-10. 10 11 1
2018	Cursons, J, Pillman, KA, Scheer, KG, Gregory, PA, Foroutan, M, Hediyeh-Zadeh, S, Toubia, J, Crampin, EJ, Goodall, GJ, Bracken, CP & Davis, MJ 2018, 'Combinatorial targeting by microRNAs co-ordinates post-transcriptional control of EMT', Cell Systems, vol. 7, no. 1, pp. 77-91. Open access 59 54 34
2018	Neumann, DP, Goodall, GJ & Gregory, PA 2018, 'Regulation of splicing and circularisation of RNA in epithelial mesenchymal plasticity', Seminars in Cell and Developmental Biology, vol. 75, pp. 50-60. Open access 13 12 1
2018	Pillman, KA, Phillips, CA, Roslan, S, Toubia, J, Dredge, BK, Bert, AG, Lumb, R, Neumann, DP, Li, X, Conn, SJ, Liu, D, Bracken, CP, Lawrence, DM, Schreiber, AW, Khew-Goodall, Y, Goodall, GJ & Gregory, PA and 4 other authors 2018, 'miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking', The EMBO Journal, vol. 37, no. 13, article no. e99016, pp. 1-20. Open access 58 58 15
2017	Das, R, Gregory, PA, Fernandes, RC, Denis, I, Lokman, NA, Ramshaw, HS, Goodall, GJ & Selth, LA 2017, 'MicroRNA-194 promotes prostate cancer metastasis by inhibiting SOCS2', Cancer Research, vol. 77, no. 4, pp. 1021-1034. Open access 83 83 61
2017	Selth, L, Das, R, Townley, S, Coutinho, I, Hanson, A, Centenera, M, Stylianou, N, Sweeney, K, Soekmadji, C, Jovanovic, L, Nelson, C, Zoubeidi, A, Butler, L, Goodall, G, Hollier, B, Gregory, P & Tilley, W 2017, 'A ZEB1-miR-375-YAP1 pathway regulates epithelial plasticity in prostate cancer', Oncogene, vol. 36, pp. 24-34. Open access 84 85 11
2017	Tse, B, Volpert, M, Ratther, E, Stylianou, N, Gregory, P & Hollier, BG 2017, 'Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality', Oncogene, vol. 36, pp. 3417-3427. Open access 49 51 8
2015	Conn, SJ, Pillman, KA, Toubia, J, Conn, VM, Salmanidis, M, Phillips, CA, Roslan, S, Schreiber, AW, Gregory, PA & Goodall, GJ 2015, 'The RNA binding protein quaking regulates formation of circRNAs', Cell, vol. 160, no. 6, pp. 1125-1134. Open access 1374 1356 21
2014	Bracken, CP, Li, X, Wright, JA, Lawrence, DM, Pillman, KA, Salmanidis, M, Anderson, MA, Dredge, BK, Gregory, PA, Tsykin, A, Neilsen, C, Thomson, DW, Bert, AG, Leerberg, JM, Yap, AS, Jensen, KB, Khew-Goodall, Y & Goodall, GJ 2014, 'Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion', The EMBO Journal, vol. 33, no. 18, pp. 2040-2056. Open access 116 115 13
2014	Das, R, Gregory, PA, Hollier, BG, Tilley, WD & Selth, LA 2014, 'Epithelial plasticity in prostate cancer: principles and clinical perspectives', Trends in Molecular Medicine, vol. 20, no. 11, pp. 643-651. 21 20 2
2014	Kolesnikoff, N, Attema, JL, Roslan, S, Bert, AG, Schwarz, QP, Gregory, PA & Goodall, GJ 2014, 'Specificity Protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition', Journal of Biological Chemistry, vol. 289, no. 16, pp. 11194-11205. Open access 55 50
2014	Li, X, Roslan, S, Johnstone, CN, Wright, J, Bracken, C, Anderson, M, Bert, A, Selth, LA, Anderson, R, Goodall, G, Gregory, PA & Khew-Goodall, Y 2014, 'MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways', Oncogene, vol. 33, no. 31, pp. 4077-4088. 98 91
2014	Yip, K-H, Kolesnikoff, N, Yu, C, Hauschild, N, Taing, H, Biggs, L, Goltzman, D, Gregory, PA, Anderson, PH, Samuel, MS, Galli, SJ, Lopez, A & Grimbaldeston, MA 2014, 'Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation', Journal of Allergy and Clinical Immunology, vol. 133, no. 5, pp. 1356-1364. Open access 88 79 27
2014	Zafar, A, Wu, F, Hardy, K, Li, J, Tu, WJ, McCuaig, R, Harris, J, Khanna, KK, Attema, J, Gregory, PA, Goodall, GJ, Harrington, K, Dahlstrom, JE, Boulding, T, Madden, R, Tan, A, Milburn, PJ & Rao, S 2014, 'Chromatinized protein kinase C-th directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells', Molecular and Cellular Biology, vol. 34, no. 16, pp. 2961-2980. 29 28
2013	Lim, Y-Y, Wright, JA, Attema, JL, Gregory, PA, Bert, AG, Smith, E, Thomas, D, Lopez, AF, Drew, PA, Khew-Goodall, Y & Goodall, GJ 2013, 'Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state', Journal of Cell Science, vol. 126, no. 10, pp. 2256-2266. Open access 165 149 2
2013	Neilsen, P, Noll, J, Mattiske, S, Bracken, C, Gregory, PA, Schulz, R, Lim, S, Kumar, R, Suetani, R, Goodall, G & Callen, D 2013, 'Mutant p53 drives invasion in breast tumors through up-regulation of miR-155', Oncogene, vol. 32, no. 24, pp. 2992-3000. Open access 133 124 4
2012	Ahn, Y-H, Gibbons, DL, Chakravarti, D, Creighton, CJ, Rizvi, ZH, Adams, HP, Pertsemlidis, A, Gregory, PA, Wright, JA, Goodall, GJ, Flores, ER & Kurie, JM 2012, 'ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression', Journal of Clinical Investigation, vol. 122, no. 9, pp. 3170-3183. Open access 130 127
2012	Callegari, S, Gregory, PA, Sykes, MJ, Bellon, J, Andrews, S, McKinnon, RA & De Barros Lopes, M 2012, 'Polymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicity', PLoS Genetics, vol. 8, no. 6, pp. 1-12. Open access 3 3
2011	Gregory, PA, Bracken, CP, Smith, E, Bert, AG, Wright, JA, Roslan, S, Morris, M, Wyatt, L, Farshid, G, Lim, Y-Y, Lindeman, GJ, Shannon, MF, Drew, PA, Khew-Goodall, Y & Goodall, GJ 2011, 'An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition', Molecular Biology of the Cell, vol. 22, no. 10, pp. 1686-1698. Open access 454 426
2011	Matsushima, K, Isomoto, H, Yamaguchi, N, Inoue, N, Gregory, PA, Goodall, GJ & Nakao, K and 14 other authors 2011, 'MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells', Journal of Translational Medicine, vol. 9, no. 30, pp. 1-12. Open access 120 117
2011	Yang, Y, Ahn, Y-H, Gibbons, DL, Zang, Y, Lin, W, Thilaganathan, N, Alvarez, CA, Moreira, DC, Creighton, C, Gregory, PA, Goodall, GJ & Kurie, JM 2011, 'The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200: dependent pathway in mice', Journal of Clinical Investigation, vol. 121, no. 4, pp. 1373-1385. Open access 170 156
2010	Hu, DG, Gardner-Stephen, D, Severi, G, Gregory, PA, Treloar, J, Giles, GG, English, DR, Hopper, J, Tilley, WD & Mackenzie, P I 2010, 'A novel polymorphism in a Forkhead Box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3alpha,17beta-diol glucuronide', Molecular Pharmacology, vol. 78, no. 4, pp. 714-722. Open access 27 26
2009	Bracken, C, Gregory, P, Khew-Goodall, Y & Goodall, G 2009, 'The role of microRNAs in metastasis and epithelial-mesenchymal transition', Cellular and Molecular Life Sciences, vol. 66, no. 10, pp. 1682-1699. 106 94
2009	Gibbons, DL, Lin, W, Creighton, CJ, Rizvi, ZH, Gregory, PA, Goodall, GJ, Thilaganathan, N, Du, L, Zhang, Y, Pertsemlidis, A & Kurie, J 2009, 'Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression', Genes and Development, vol. 23, no. 18, pp. 2140-2151. Open access 408 391
2008	Bracken, CP, Gregory, PA, Kolesnikoff, N, Bert, AG, Wang, J, Shannon, MF & Goodall, GJ 2008, 'A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition', Cancer Research, vol. 68, no. 19, pp. 7846-7854. Open access 882 833
2008	Gregory, PA, Bert, A, Paterson, E, Barry, S, Tsykin, A, Farshid, G, Vadas, M, Khew-Goodall, Y & Goodall, G 2008, 'The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1', Nature Cell Biology, vol. 10, no. 5, pp. 593-601. 3199 3020
2008	Gregory, PA, Bracken, CP, Bert, AG & Goodall, GJ 2008, 'MicroRNAs as regulators of epithelial-mesenchymal transition', Cell Cycle, vol. 7, no. 20, pp. 3112-3117. Open access 423 392
2008	Paterson, E, Prizzi, N, Gregory, PA, Bert, A, Khew-Goodall, Y & Goodall, G 2008, 'The microRNA-200 Family Regulates Epithelial to Mesenchymal Transition', The Scientific World Journal, vol. 8, pp. 901-904. Open access 73 69

Other outputs

Gomez GA, Woodcock JM, Tergaonkar V, GREGORY PA (2018) Meeting Report: The 8th Barossa Meeting-Cell Signaling in Cancer Medicine in the Barossa Valley, Australia. CELL DEATH DIS. 2018 Feb 15;9(3):284.

External engagement & recognition

Collaborations

Highlights

Runner-up for the Inaugural Peter Sutherland Award (2019)

South Australian Young Tall Poppy Science Award (2011)

Hanson Institute New Basic Science Investigator Award (2009)

External engagement & recognition

Collaborations

Organisation	Country
Australian National University	AUSTRALIA
Baylor College of Medicine	UNITED STATES
Canberra Hospital	AUSTRALIA
Cancer Council of South Australia	AUSTRALIA
Cancer Council Victoria	AUSTRALIA
Ecole Nationale Superieure de Chimie, de Biologie et de Physique de Bordeaux	FRANCE
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Hanson Institute	AUSTRALIA
Institute of Medical and Veterinary Science	AUSTRALIA
Karolinska Institute	SWEDEN
La Trobe University	AUSTRALIA
Mahidol University	THAILAND
McGill University	CANADA
Monterrey Institute Of Technology And Higher Education	MEXICO
Nagasaki University	JAPAN
Olivia Newton-John Cancer Research Institute	AUSTRALIA
Peter MacCallum Cancer Centre	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Royal Brisbane and Women's Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
St Vincent's Hospital	AUSTRALIA
Stanford University	UNITED STATES
The Australian Wine Research Institute	AUSTRALIA
Translation Research Institute Australia	AUSTRALIA
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Canberra	AUSTRALIA
University of Malaya	MALAYSIA
University of Melbourne	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Texas	UNITED STATES
University of Texas MD Anderson Cancer Centre	UNITED STATES
Walter & Eliza Hall Institute	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Conference Convenor Third Australia-India EMT meeting	2019
Invited National Review Panel Member National Health and Medical Research Council (NHMRC)	2019
Invited Speaker Genetics Society of AustralAsia Conference	2019
Member Secretary of EMT International Association	2019
Runner-up Peter Sutherland Award PacRim Breast & Prostate Cancer Meeting	2019
Invited Lecture Olivia Newton John Cancer Research Institute	2018
Invited National Review Member Cancer Australia Grant Review Panel	2018
Member Secretary of EMT International Association	2018
Principal Research Fellowship Beat Cancer	2018
Project Grant National Health and Medical Research Council (NHMRC)	2018
Co-supervisor of a PhD student at Adelaide University The University of Adelaide	2017
Member Secretary of EMT International Association	2017
Co-supervisor of a PhD student at Adelaide University The University of Adelaide	2016
Invited National Review Panel Member National Health and Medical Research Council (NHMRC)	2016
Member Secretary of EMT International Association	2016
Project Grant National Health and Medical Research Council (NHMRC)	2016
Primary Supervisor of a PhD student at Adelaide University The University of Adelaide	2014
Tall Poppy of the Year Award Australian Institute of Policy and Science	2011

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
A novel protein ZCCHC24 as a regulator of breast cancer cell plasticity and metastasis	Current
Alternative splicing networks and their impact on the development of aggressive prostate cancer	Current
Nuclear functions of microRNAs that control EMT in breast cancer	Current
Targeting oncogenic signalling with custom RNA drugs	Current
The role of RNA-binding proteins in epithelial-mesenchymal transition	Completed

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Associate Professor Philip Gregory

About me

About me

Centre for Cancer Biology

About me

Professional Associations

In the media

Experience

Qualifications

Work history

Research

Research focus

Highlights

Projects

Other projects

Outputs

Highlights

Journal Articles

Other outputs

Current research & highlights

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Conference Convenor

Invited National Review Panel Member

Invited Speaker

Member

Runner-up Peter Sutherland Award

Invited Lecture

Invited National Review Member

Member

Principal Research Fellowship

Project Grant

Co-supervisor of a PhD student at Adelaide University

Member

Co-supervisor of a PhD student at Adelaide University

Invited National Review Panel Member

Member

Project Grant

Primary Supervisor of a PhD student at Adelaide University

Tall Poppy of the Year Award

Teaching & student supervision

Courses and programs

Research degree supervision

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