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Associate Professor Rietie Venter

  • Associate Professor School of Pharmacy and Medical Sciences
  • City East Campus (P4-03)
  • tel +61 8 830 21515
  • email Rietie.Venter@unisa.edu.au
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About me

About me

Associate Professor Rietie Venter
  • Antimicrobial resistance
  • Drug efflux proteins
  • Novel antibiotics
  • Mechanisms of resistance
  • Multidrug resistance
I obtained my BSc Hons and Master’s degrees with distinction from the University of the Free State in South Africa. As top student in my BSc Hons class I secured an international scholarship to fund my PhD studies at the University of Leeds. After completing my PhD on membrane protein biochemistry at the University of Leeds in the beautiful Yorkshire Dales, I moved to Cambridge, where I spend twelve years doing research on multidrug transporters, first as a post-doc and later running my own research group as a Royal Society Dorothy Hodgkin Fellow in the Department of Pharmacology at the University of Cambridge. During this time, I was also appointed as College Lecturer in Robinson College, University of Cambridge, where I did small-group... Read more

School of Pharmacy and Medical Sciences

With standout facilities and strong industry links, the School prepares students for careers in health and medical science.

Other UniSA associations

  • Head of the Microbiology and Infectious Disease Group in the Sansom Institute for Health Research
  • Member of the Australian Bioactive Compounds Centre
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About me

I obtained my BSc Hons and Master’s degrees with distinction from the University of the Free State in South Africa. As top student in my BSc Hons class I secured an international scholarship to fund my PhD studies at the University of Leeds. After completing my PhD on membrane protein biochemistry at the University of Leeds in the beautiful Yorkshire Dales, I moved to Cambridge, where I spend twelve years doing research on multidrug transporters, first as a post-doc and later running my own research group as a Royal Society Dorothy Hodgkin Fellow in the Department of Pharmacology at the University of Cambridge. During this time, I was also appointed as College Lecturer in Robinson College, University of Cambridge, where I did small-group tutoring and teaching. Not content with moving continents once in a lifetime, I left the ancient buildings and immaculate college lawns of Cambridge for sun and sea in Australia after sixteen years in the UK. I joined the University of South Australia as Senior Lecturer and Head of Microbiology in the School of Pharmacy and Medical Sciences in December 2012.
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Professional Associations

Australian Society for Microbiology, Australian Society for Antimicrobials, Australian Society for Biochemistry and Molecular Biology, Adelaide Protein Group, American Society for Microbiology, Member of the Institutional Biosafety Committee.

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Experience

Qualifications

  • Doctor of Phiosophy The University of Leeds

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  • Professional associations
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Research

Research themes

  • Scarce resources
  • Healthy futures

Research focus

  • Microbiology
  • Biochemistry and Cell Biology
  • Biological Sciences
  • Medical and Health Sciences
  • Pharmacology and Pharmaceutical Sciences

Highlights

My research focuses on antimicrobial resistance. ‘Superbugs’ are costing the medical and veterinary industry billions of dollars a year and antimicrobial resistance is one of the world’s most pressing health problems. According to the WHO we are fast approaching a post-antibiotic era where small injuries and minor infections will once again be fatal. Work in my laboratory is aimed at finding novel ways of treating infectious disease by characterising bacterial membrane proteins that are involved in drug resistance and/or virulence and on developing drugs that act on these targets. We are currently working on drug efflux pumps, iron transporters and cell division proteins in pathogenic bacteria. Most of our work... Read more

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Research

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Projects

Excludes commercial-in-confidence projects.

  • Turning antimicrobial resistance in residential aged care inside-out from the patient to facility level, MRFF - Targeted Call for Research - Antimicrobial Resistance, 26/06/2018 - 31/12/2022

  • Reversing antibiotic resistance with efflux pump inhibitors, NHMRC - Project Grant, 01/01/2018 - 31/12/2020

  • Improving safety of vegetable produce through on‐farm sanitation, using Electrolysed Oxidising (EO) Water - VG15068, HIA Horticulture Innovation Australia, 01/06/2017 - 31/05/2020

  • Research Infrastructure Fund (RIF) Grant 2016 Round 2 - Biofilm Testing Facility, Adelaide Integrated Bioscience Laboratories, 28/11/2016 - 31/12/2017

  • Investigation of new anti-bacterials from Australian medicinal plants, James N Kirby Foundation, 01/07/2014 - 30/09/2015

Other projects

We run an antimicrobial screening facility where we screen natural and synthetic compounds for antimicrobial activity, antibiofilm activity and the reversal of resistance.

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Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year Output
2015

Venter, R, Mowla, R, Ohene-Agyei, T & Ma, S 2015, 'RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition', Frontiers in Microbiology, vol. 6, article no. 377, pp. 1-11.

Open access 76 71 1
2014

Ohene-Agyei, T, Mowla, R, Rahman, T & Venter, R 2014, 'Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump0', MicrobiologyOpen, vol. 3, no. 6, pp. 885-896.

Open access 30 33 3
2009

Barrera, N, Isaacson, S, Zhou, M, Bavro, V, Welch, A, Schaedler, T, Seeger, M, Miguel, R, Korkhov, V, Van Veen, H, Venter, H, Walmsley, A, Tate, C & Robinson, C 2009, 'Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions', Nature Methods, vol. 6 no. 8, pp. 585-587.

123

Chapters

Year Output
2013

Du, D, Venter, H, Pos, KM & Luisi, BF 2013, 'The machinery and mechanism of multidrug efflux in Gram-negative bacteria', in EW Yu, Q Zhang & MH Brown (eds), Microbial efflux pumps: current research, Caister Academic Press, UK, ch. 3, pp. 35-49.

2008

Roach, PC, O'Reilly, J, Norbertczak, H, Hope, R, Venter, H, Patching, S, Jamshad, M, Stockley, PG, Baldwin, SA, Herbert, RB, Rutherford, NG, Bill, RM & Henderson, PJ 2008, 'Equipping a Research Scale Fermentation Laboratory for Production of Membrane Proteins', in B McNeil & LM Harvey, Practical Fermentation Technology, John Wiley & Sons, US, ch. 3, pp. 37 - 68.

Journal Articles

Year Output
2019

Imani Rad, H, Peeri, H, Amani, M, Mohammadnia, A, Ogunniyi, AD, Khazandi, M, Venter, H & Arzanlou, M 2019, 'Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro', Microbial Pathogenesis, vol. 132, pp. 293-301.

2019

Jin, C, Alenazy, R, Wang, Y, Mowla, R, Qin, Y, Tan, JQE, Modi, ND, Gu, X, Polyak, SW, Venter, H & Ma, S 2019, 'Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance', Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 7, pp. 882-889.

1 1
2019

Khazandi, M, Pi, H, Chan, WY, Ogunniyi, AD, Sim, JXF, Venter, H, Garg, S, Page, SW, Hill, PB, McCluskey, A & Trott, DJ 2019, 'In vitro antimicrobial activity of robenidine, ethylenediaminetetraacetic acid and polymyxin B nonapeptide against important human and veterinary pathogens', Frontiers in Microbiology, vol. 10, article no. 837, pp. 1-15.

Open access 2 2 1
2019

Sim, J, Khazandi, M, Pi, H, Venter, H, Trott, D & Deo, P 2019, 'Antimicrobial effects of cinnamon essential oil and cinnamaldehyde combined with EDTA against canine otitis externa pathogens', Journal of Applied Microbiology, vol. 127, no. 1, pp. 99-108.

1 1
2019

Venter, H 2019, 'Reversing resistance to counter antimicrobial resistance in the World Health Organisation's critical priority of most dangerous pathogens', Bioscience Reports: Molecular and Cellular Biology of the Cell Surface, vol. 29, no. 4, article no. BSR20180474, pp. 1-12.

Open access 1
2019

Wang, Y, Alenzy, R, Song, D, Liu, X, Teng, Y, Mowla, R, Ma, Y, Polyak, SW, Venter, H & Ma, S 2019, 'Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors', European Journal of Medicinal Chemistry, in press, pp. 1-18.

2018

Bi, F, Ji, S, Venter, H, Liu, J, Semple, SJ & Ma, S 2018, 'Substitution of terminal amide with 1H-1,2,3-triazole: Identification of unexpected class of potent antibacterial agents', Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 5, pp. 884-891.

6 7 1
2018

Bi, F, Song, D, Zhang, N, Liu, Z, Gu, X, Hu, C, Cai, X, Venter, H & Ma, S 2018, 'Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators', European Journal of Medicinal Chemistry, vol. 159, pp. 90-103.

6 5 1
2018

Khazandi, M, Al-Farha, AAB, Coombs, GW, O'Dea, M, Pang, S, Trott, DJ, Aviles, RR, Hemmatzadeh, F, Venter, H, Ogunniyi, AD, Hoare, A, Abraham, S & Petrovski, KR 2018, 'Genomic characterization of coagulase-negative staphylococci including methicillin-resistant Staphylococcus sciuri causing bovine mastitis', Veterinary Microbiology, vol. 219, pp. 17-22.

Open access 3 2 1
2018

Liu, J, Ma, R, Bi, F, Zhang, F, Hu, C, Venter, H, Semple, SJ & Ma, S 2018, 'Novel 5-methyl-2-phenylphenanthridium derivatives as FtsZ-targeting antibacterial agents from structural simplification of natural product sanguinarine', Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 10, pp. 1825-1831.

5 4
2018

Mowla, R, Wang, Y, Ma, S & Venter, H 2018, 'Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance', BBA: Biomembranes, vol. 1860, no. 4, pp.878-886.

Open access 7 5 1
2018

Ogunniyi, AD, Kopecki, Z, Hickey, EE, Khazandi, M, Peel, E, Belov, K, Boileau, A, Garg, S, Venter, H, Chan, WY, Hill, PB, Page, SW, Cowin, AJ & Trott, DJ 2018, 'Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing', PLoS One, vol. 13, no. 7, article no. e0200195, pp. 1-13.

Open access 3 4 3
2018

Wang, Y, Mowla, R, Ji, S, Guo, L, De Barros Lopes, MA, Jin, C, Song, D, Ma, S & Venter, H 2018, 'Design, synthesis and biological activity evaluation of novel 4-subtituted 2-naphthamide derivatives as AcrB inhibitors', European Journal of Medicinal Chemistry, vol. 143, pp. 699-709.

5 5
2017

Arzanlou, M, Chai, WC & Venter, H 2017, 'Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria', Essays in Biochemistry, vol. 61, no. 1, pp. 49-59.

19 18 38
2017

Bi, F, Guo, L, Wang, Y, Venter, H, Semple, SJ, Liu, F & Ma, S 2017, 'Design, synthesis and biological activity evaluation of novel 2,6-difluorobenzamide derivatives through FtsZ inhibition', Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 4, pp. 958-962.

12 11
2017

Khazandi, M, Deo, P, Ferro, S, Venter, H, Pi, H, Crabb, S, Amorico, T, Ogunniyi, AD & Trott, DJ 2017, 'Efficacy evaluation of a new water sanitizer for increasing the shelf life of Southern Australian King George whiting and Tasmanian atlantic salmon fillets', Food Microbiology, vol. 68, pp. 51-60.

Open access 4 2 2
2017

Liu, F, Venter, H, Bi, F, Semple, SJ, Liu, J, Jin, C & Ma, S 2017, 'Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 15, pp. 3399-3402.

4 5
2017

Mahbub, KR, Krishnan, K, Andrews, S, Venter, H, Naidu, R & Megharaj, M 2017, 'Bio-augmentation and nutrient amendment decrease concentration of mercury in contaminated soil', Science of the Total Environment, vol. 576, pp. 303-309.

19 17
2017

Ogunniyi, AD, Khazandi, M, Stevens, AJ, Sims, SK, Page, SW, Garg, S, Venter, H, Powell, A, White, K, Petrovski, KR, Laven-Law, G, Tótoli, EG, Salgado, HR, Pi, H, Coombs, GW, Shinabarger, DL, Turnidge, JD, Paton, JC, McCluskey, A & Trott, DJ 2017, 'Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent', PLoS One, vol. 12, no. 9, article no. e0183457, pp. 1-23.

Open access 10 11 2
2017

Venter, H, Henningsen, ML & Begg, SL 2017, 'Antimicrobial resistance in healthcare, agriculture and the environment: The biochemistry behind the headlines', Essays in Biochemistry, vol. 61, no. 1, pp. 1-10.

Open access 22 20 1
2017

Wang, Y, Mowla, R, Guo, L, Ogunniyi, AD, Rahman, T, De Barros Lopes, MA, Ma, S & Venter, H 2017, 'Evaluation of a series of 2-napthamide derivatives as inhibitors of the drug efflux pump AcrB for the reversal of antimicrobial resistance', Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 4, pp. 733-739.

Open access 8 6
2016

Qiang, S, Wang, C, Venter, H, Li, X, Wang, Y, Guo, L, Ma, R & Ma, S 2016, 'Synthesis and biological evaluation of novel FtsZ-targeted 3-arylalkoxy-2,6-difluorobenzamides as potential antimicrobial agents', Chemical Biology and Drug Design, vol. 87, no. 2, pp. 257-264.

Open access 3 3 3
2016

Seyedmohammad, S, Fuentealba, NA, Marriott, RA, Goetze, TA, Edwardson, JM, Barrera, NP & Venter, H 2016, 'Structural model of FeoB, the iron transporter from Pseudomonas aeruginosa, predicts a cysteine lined, GTP-gated pore', Bioscience Reports: Molecular and Cellular Biology of the Cell Surface, vol. 36, article no. 00322, pp. 1-13.

Open access 9 7 3
2016

Wang, Y, Venter, H & Ma, S 2016, 'Efflux pump inhibitors: a novel approach to combat efflux-mediated drug resistance in bacteria', Current Drug Targets, vol. 17, no. 6, pp. 702-719.

26 28
2016

Yan, M, Ma, R, Jia, L, Venter, H & Ma, S 2016, 'Synthesis and antibacterial activity of novel 3-O-descladinosylazithromycin derivatives', European Journal of Medicinal Chemistry, vol. 127, pp. 874-884.

3 3 3
2015

Venter, R, Mowla, R, Ohene-Agyei, T & Ma, S 2015, 'RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition', Frontiers in Microbiology, vol. 6, article no. 377, pp. 1-11.

Open access 76 71 1
2014

Du, D, Wang, Z, James, NR, Voss, JE, Klimont, E, Ohene-Agyei, T, Venter, H, Chiu, W & Luisi, BF 2014, 'Structure of the AcrAB-TolC multidrug efflux pump', Nature, vol. 509, no. 7501, pp. 512-515.

Open access 238 228 10
2014

Ohene-Agyei, T, Mowla, R, Rahman, T & Venter, R 2014, 'Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump0', MicrobiologyOpen, vol. 3, no. 6, pp. 885-896.

Open access 30 33 3
2014

Seyedmohammad, S, Born, D & Venter, H 2014, 'Expression, purification and functional reconstitution of FeoB, the ferrous iron transporter from Pseudomonas aeruginosa', Protein Expression and Purification, vol. 101, pp. 138-145.

9 9
2012

Ohene-Agyei, T, Lea, JD & Venter, H 2012, 'Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets', FEMS Microbiology Letters, vol. 333, no. 1, pp. 20-27.

Open access 15 16
2010

Welch, A, Awah, C, Jing, S, Van, VH & Venter, R 2010, 'Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa', Biochemical Journal, vol. 430 no. 2, pp. 355-364.

30 28
2009

Barrera, N, Isaacson, S, Zhou, M, Bavro, V, Welch, A, Schaedler, T, Seeger, M, Miguel, R, Korkhov, V, Van Veen, H, Venter, H, Walmsley, A, Tate, C & Robinson, C 2009, 'Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions', Nature Methods, vol. 6 no. 8, pp. 585-587.

123
2009

Velamakanni, S, Lau, CH, Gutmann, DA, Venter, H, Barrera, NP, Seeger, MA, Woebking, B, Matak-Vinkovic, D, Balakrishnan, L, Yao, Y, U, EC, Shilling, RA, Robinson, C V, Thorn, P & van, HHW 2009, 'A multidrug ABC transporter with a taste for salt', PLoS One, vol. 4 no. 7, article no. e6137, pp. 1-9.

Open access 27
2008

Venter, H, Velamakanni, S, Balakrishnan, L & Van Veen, H 2008, 'On the energy-dependence of Hoechst 33342 transport by the ABC transporter LmrA', Biochemical Pharmacology, vol. 75, no. 4, pp. 866-874.

35 33
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Current research & highlights

My research focuses on antimicrobial resistance. ‘Superbugs’ are costing the medical and veterinary industry billions of dollars a year and antimicrobial resistance is one of the world’s most pressing health problems. According to the WHO we are fast approaching a post-antibiotic era where small injuries and minor infections will once again be fatal. Work in my laboratory is aimed at finding novel ways of treating infectious disease by characterising bacterial membrane proteins that are involved in drug resistance and/or virulence and on developing drugs that act on these targets. We are currently working on drug efflux pumps, iron transporters and cell division proteins in pathogenic bacteria. Most of our work focusses on the Gram-negative pathogen P. aeruginosa. This pathogen is associated with a range of life-threatening nosocomial infections and is the main cause of mortality in patients with cystic fibrosis. P. aeruginosa infections are hard to treat since this organism displays resistance against multiple classes of antimicrobials. Central to this bacterium’s high intrinsic drug resistance is the expression of drug efflux pumps and its ability to form antibiotic-tolerant biofilms.

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External engagement & recognition

Collaborations

Highlights

  • Guest Editor for a special issue on 'Antimicrobial Resistance' for Essays in Biochemistry
  • Member of the Editorial board of the 'Antimicrobials, Resistance and Chemotherapy', section of Frontiers in Microbiology
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External engagement & recognition

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Collaborations

Organisation Country
Ardabil University of Medical Sciences IRAN
Baylor College of Medicine UNITED STATES
CRC Care AUSTRALIA
Deakin University AUSTRALIA
ECAS4 Australia AUSTRALIA
Ecas4 Pty Ltd AUSTRALIA
Flinders University AUSTRALIA
Ghent University BELGIUM
Goethe University Frankfurt GERMANY
Luoda Pharma Pty Ltd AUSTRALIA
Micromyx UNITED STATES
Monash University AUSTRALIA
Murdoch University AUSTRALIA
Neoculi Pty Ltd AUSTRALIA
Pontifical Catholic University of Chile CHILE
Qingdao University CHINA
Queen Elizabeth Hospital AUSTRALIA
ReaLi Tide Biological Technology CHINA
ReaLi Tide Biological Technology (Weihai) Co. Ltd CHINA
Sao Paulo State University BRAZIL
Shandong University CHINA
South Australian Research and Development Institute (SARDI) AUSTRALIA
South East Vets UNITED STATES
University of Adelaide AUSTRALIA
University of Cambridge UNITED KINGDOM
University of Copenhagen DENMARK
University of Durham UNITED KINGDOM
University of Newcastle AUSTRALIA
University of Oxford UNITED KINGDOM
University of South Australia AUSTRALIA
University of Sydney AUSTRALIA
Univesity of Science and Technology of China CHINA
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External engagement & recognition

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External engagement & recognition

Engagement/recognition Year

Editorial Board Member ('Antimicrobials, Resistance and Chemotherapy')

Frontiers in Microbiology

2017

Guest Editor for a special issue

Essays in Biochemistry

2017

Member

The Australian Society for Microbiology

2017

Member

Australian Society for Antimicrobials

2017

Member

Australian Society for Biochemistry and Molecular Biology (ASBMB)

2017

Member

Adelaide Protein Group, Australian Society for Biochemistry and Molecular Biology (ASBMB)

2017

Member

American Society for Microbiology

2017
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Courses and programs

Courses I teach and/or co-ordinate

  • BIOL 2051 Microbiology (2019)
  • BIOL 2051 Microbiology (2018)

Programs I'm associated with

  • IBBL - Bachelor of Laboratory Medicine
  • IBMS - Bachelor of Medical Science
  • IHPC - Bachelor of Pharmacy (Honours)
  • IHPP - Bachelor of Pharmaceutical Science, Bachelor of Pharmacy (Honours)
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Research degree supervision

Supervisions from 2010 shown

Thesis title Student status
A combined in silico and microbiological approach for the identification of efflux pump inhibitors from natural products. Current
Anti-Microbial activity of natural and synthetic compounds against multi-drug resistant microorganisms Current
Investigation of the activity of a caspofungin-grafted surface coating on attaching pathogenic fungi Current
Phenotypic screening and molecular characterization of Extended-Spectrum ß-Lactamase and Carbapenemase-Producing Klebsiella pneumoniae and identify mechanism of resistance Current
Reversing multidrug resistance with efflux pump inhibitors Current
Risk factors in the development and dissemination of antimicrobial resistance in residential age care facilities Current
The effect of hospital effluent on the antimicrobial resistance ecology of waste water. Current
Inhibitors of efflux  to reverse resistance in Escherichia coli Completed
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Gallery

Associate Professor Rietie Venter
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