Associate Professor Bob Milne

Adjunct Associate Research Professor UniSA Clinical & Health Sciences

Non standard campus (Sth Aust) ()
tel +61 8 830 20126

email Robert.Milne@unisa.edu.au

Research Degree Supervisor

About me

Welcome. I worked within the School of Pharmacy and Medical Sciences for many decades, but I have now retired from full-time employment. I have had many years of experience in teaching, research and consulting in pharmacy and pharmaceutical science. I have consulted widely to the pharmaceutical and biotechnology industry on pre-clinical and clinical studies, and worked closely with CPR Pharma, a spin-out company from UniSA. I have also provided scientific advice to patent firms on matters related to pharmaceutical science.

I now work part-time with the Drug Discovery and Development group, which is within the Centre for Cancer Diagnostics and Therapeutics. My contribution is research and supervision of doctoral... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research focus

Pharmacology and Pharmaceutical Sciences
Biochemistry and Cell Biology
Medical Microbiology
Analytical Chemistry
Medicinal and Biomolecular Chemistry

Highlights

Drug discovery - preclinical development, pharmacokinetics and metabolism of drugs and their metabolites, drug analysis.

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2019	Milne, RW 2019, 'Bioanalysis and stability of polymyxins', Polymyxin antibiotics: from laboratory bench to bedside, Springer, Switzerland, ch. 6, pp. 73-87. 5

Journal Articles

Year	Output
2022	Anshabo, AT, Bantie, L, Diab, S, Lenjisa, J, Kebede, A, Long, Y, Heinemann, G, Karanjia, J, Noll, B, Basnet, SK, Li, M, Milne, R, Albrecht, H & Wang, S 2022, 'An orally bioavailable and highly efficacious inhibitor of CDK9/FLT3 for the treatment of acute myeloid leukemia', Cancers, vol. 14, no. 5, article no. 1113, pp. 1-19. Open access 9 8 23
2022	Wang, W, Joyce, P, Bremmell, K, Milne, R & Prestidge, CA 2022, 'Liposomal 5-fluorouracil polymer complexes facilitate tumor-specific delivery: pharmaco-distribution kinetics using microdialysis', Pharmaceutics, vol. 14, no. 2, article no. 221, pp. 1-16. Open access 9 7 333
2021	Anshabo, AT, Milne, R, Wang, S & Albrecht, H 2021, 'CDK9: A comprehensive review of its biology, and its role as a potential target for anti-cancer agents', Frontiers in Oncology, vol. 11, article no. 678559, pp. 1-24. Open access 81 81 2
2021	Yu, M, Teo, T, Yang, Y, Li, M, Long, Y, Philip, S, Noll, B, Heinemann, GK, Diab, S, Eldi, P, Mekonnen, L, Anshabo, AT, Rahaman, MH, Milne, R, Hayball, JD & Wang, S 2021, 'Potent and orally bioavailable CDK8 inhibitors: design, synthesis, structure-activity relationship analysis and biological evaluation', European Journal of Medicinal Chemistry, vol. 214, pp. 1-22. Open access 12 11 1
2020	Bantie, L, Tadesse, S, Likisa, J, Yu, M, Noll, B, Heinemann, G, Lokman, NA, Ricciardelli, C, Oehler, MK, Beck, A, Pradhan, R, Milne, R, Albrecht, H & Wang, S 2020, 'A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer', Gynecologic Oncology, vol. 159, no. 3, pp. 827-838. 10 13 1
2020	Ellis, DP, Rozek, T & Milne, RW 2020, 'Stability of a compounded oral liquid formulation of clopidogrel for infants', Journal of Pharmacy Practice and Research, vol. 50, no. 4, pp. 321-328. 2
2019	Abdelaziz, AM, Diab, S, Islam, S, KC Basnet, S, Noll, B, Li, P, Mekonnen, LB, Lu, J, Albrecht, H, Milne, RW, Gerber, C, Yu, M & Wang, S 2019, 'Discovery of n-phenyl-4-(1h-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent mnk2 inhibitors: design, synthesis, sar analysis, and evaluation of in vitro anti-leukaemic activity', Medicinal Chemistry, vol. 15, no. 6, pp. 600-621. 6 5
2019	Khair, NZ, Lenjisa, JL, Tadesse, S, Kumarasiri, M, Basnet, SK, Mekonnen, LB, Li, M, Diab, S, Sykes, MJ, Albrecht, H, Milne, R & Wang, S 2019, 'Discovery of CDK5 inhibitors through structure-guided approach', ACS Medicinal Chemistry Letters, vol. 10, no. 5, pp. 786-791. Open access 21 19 1
2019	Lee, KJ, Tieu, W, Blanco-Rodriguez, B, Paparella, AS, Yu, J, Hayes, A, Feng, J, Marshall, AC, Noll, B, Milne, R, Cini, D, Wilce, MC, Booker, GW, Bruning, JB, Polyak, SW & Abell, AD 2019, 'Sulfonamide-based inhibitors of biotin protein ligase as new antibiotic leads', ACS Chemical Biology, vol. 14, no. 9, pp. 1990-1997. Open access 8 7
2019	Rahaman, MH, Lam, F, Zhong, L, Teo, T, Adams, J, Yu, M, Milne, RW, Pepper, C, Lokman, NA, Ricciardelli, C, Oehler, MK & Wang, S 2019, 'Targeting CDK9 for treatment of colorectal cancer', Molecular Oncology, vol. 13, no. 10, pp. 2178-2193. Open access 41 38
2019	Rahaman, MH, Yu, Y, Zhong, L, Adams, J, Lam, F, Li, P, Noll, B, Milne, R, Peng, J & Wang, S 2019, 'CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia', Investigational New Drugs, vol. 37, no. 4, pp. 625-635. 28 27 3
2018	Licari, G, Milne, RW, Somogyi, AA & Sallustio, BC 2018, 'Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats', Pharmacology Research and Perspectives, vol. 6, no. 3, article no. e00406, pp. 1-8. Open access 3 3
2018	Tadesse, S, Bantie, L, Tomusange, K, Yu, M, Islam, S, Bykovska, N, Noll, B, Zhu, G, Li, P, Lam, F, Kumarasiri, M, Milne, R & Wang, S 2018, 'Discovery and pharmacological characterisation of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents', British Journal of Pharmacology, vol. 175, no. 12, pp. 2399-2413. Open access 21 20 3
2017	Bai, PY, Wittert, G, Taylor, AW, Martin, SA, Milne, RW, Jenkins, AJ, Januszewski, AS & Shi, Z 2017, 'The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men', Environmental Research, vol. 158, pp. 366-372. 37 37
2017	Diab, S, Abdelaziz, AM, Li, P, Teo, T, Basnet, SK, Noll, B, Rahaman, MH, Lu, J, Hou, J, Yu, M, Le, BT, Albrecht, H, Milne, RW & Wang, S 2017, 'Dual inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia', European Journal of Medicinal Chemistry, vol. 139, pp. 762-772. Open access 23 21
2017	Lenjisa, JL, Tadesse, S, Khair, NZ, Kumarasiri, M, Yu, M, Albrecht, H, Milne, R & Wang, S 2017, 'CDK5 in oncology: recent advances and future prospects.', Future Medicinal Chemistry, vol. 9, no. 16, pp. 1939-1962. Open access 32 31
2017	Turkanovic, J, Ward, MB, Gerber, JP & Milne, RW 2017, 'Effect of garlic, gingko, and St. John's wort extracts on the pharmacokinetics of fexofenadine: a mechanistic study', Drug Metabolism and Disposition, vol. 45, no. 5, pp. 569-575. Open access 9 6
2017	Zeleke, S, Yu, M, Mekonnen, LB, Lam, F, Islam, S, Tomusange, K, Rahaman, MH, Noll, B, MC Basnet, S, Teo, T, Albrecht, H, Milne, R & Wang, S 2017, 'Highly potent, selective, and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependent kinases 4 and 6 inhibitors as anticancer drug candidates: design, synthesis, and evaluation', Journal of Medicinal Chemistry, vol. 60, no. 5, pp. 1892-1915. Open access 64 59 9
2016	Diab, S, Li, P, MC Basnet, S, Lu, J, Yu, M, Albrecht, H, Milne, RW & Wang, S 2016, 'Unveiling new chemical scaffolds as Mnk inhibitors', Future Medicinal Chemistry, vol. 8, no. 3, pp. 271-285. 20 19 3
2016	Li, P, Diab, S, Yu, M, Adams, J, Islam, S, MC Basnet, S, Albrecht, H, Milne, RW & Wang, S 2016, 'Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells', Oncotarget, vol.7, no.35, pp.1-15. Open access 22 21 3
2016	Rahaman, MH, Kumarasiri, M, Mekonnen, LB, Yu, M, Diab, S, Albrecht, H, Milne, RW & Wang, S 2016, 'Targeting CDK9: a promising therapeutic opportunity in prostate cancer', Endocrine-Related Cancer, vol. 23, no. 12, pp. T211-T226. Open access 57 54 5
2015	Bai, PY, Wittert, GA, Taylor, AW, Martin, SA, Milne, RW & Shi, Z 2015, 'The association of socio-demographic status, lifestyle factors and dietary patterns with total urinary phthalates in Australian men', PLoS One, vol. 10, no. 4, article no. e0122140, pp. 1-13. Open access 29 27
2015	Le, BT, Kumarasiri, M, Adams, JRJ, Yu, M, Milne, RW, Sykes, MJ & Wang, S 2015, 'Targeting Pim kinases for cancer treatment : opportunities and challenges', Future Medicinal Chemistry, vol. 7, no. 1, pp. 35-53. 39 40 9
2014	Diab, S, Kumarasiri, M, Yu, M, Teo, T, Proud, C, Milne, R & Wang, S 2014, 'MAP kinase-interacting kinases: emerging targets against cancer', Chemistry and Biology, vol. 21, no. 4, pp. 441-452. Open access 85 82 11
2014	Diab, S, Teo, THS, Kumarasiri, M, Li, P, Yu, M, Lam, F, MC Basnet, S, Sykes, MJ, Albrecht, H, Milne, R & Wang, S 2014, 'Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors : synthesis, SAR analysis and biological evaluation', ChemMedChem: chemistry enabling drug discovery, vol. 9, no. 5, pp. 962-972. Open access 71 69 1
2014	Grant, J, Martin, S, Taylor, A, Wilson, D, Araujo, A, Adams, R, Jenkins, A, Milne, RW, Hugo, G, Atlantis, E & Wittert, G 2014, 'Cohort Profile: the men androgen inflammation lifestyle environment and stress (MAILES) study', International Journal of Epidemiology, vol. 43, no. 4, pp. 1040-1053. Open access 56 52
2014	Licari, G, Somogyi, AA, Milne, RW & Sallustio, BC 2014, 'Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague-Dawley and Dark Agouti rats', Xenobiotica: The Fate of Foreign Compounds in Biological Systems, vol. 45, no. 1, pp. 3-9. 3 3
2014	Lu, T, Goh, AW, Yu, M, Adams, J, Lam, F, Teo, T, Li, P, Noll, B, Zhong, L, Diab, S, Chahrour, O, Hu, A, Abbas, AY, Liu, X, Huang, S, Sumby, CJ, Milne, R, Midgley, C & Wang, S 2014, 'Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities', Journal of Medicinal Chemistry, vol. 57, no. 6, pp. 2275-2291. Open access 28 27 3
2012	Mihaila, B, Ellis, D, Rozek, T & Milne, R 2012, 'Chiral stability study of oral liquid clopidogrel formulations for infants', Journal of Pharmacy Practice and Research, vol. 42, no. 2, pp. 106-110. Open access 2
2011	Death, CE, Taggart, DA, Williams, DB, Milne, R, Schultz, DJ, Holyoake, C & Warren, KS 2011, 'Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons)', Journal of Wildlife Diseases, vol. 47, no. 3, pp. 643-649. Open access 19 18
2011	Wiese, MD, Davies, NW, Chataway, TK, Milne, RW, Brown, SG & Heddle, RJ 2011, 'Stability of Myrmecia pilosula (Jack Jumper) ant venom for use in immunotherapy', Journal of Pharmaceutical and Biomedical Analysis, vol. 54, no. 2, pp. 303-310. 12 12
2010	Qi, X, Evans, AM, Wang, J, Miners, J, Upton, RN & Milne, RW 2010, 'Inhibition of morphine metabolism by ketamine', Drug Metabolism and Disposition, vol. 38, no. 5, pp. 728-731. 30 25
2010	Rayner, C, Milne, RW, Coulthard, K, Turnidge, J, Li, J, Nation, R & Dudhani, R V 2010, 'Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models', Antimicrobial Agents and Chemotherapy, vol. 54, no. 3, pp. 1117-1124. Open access 165 162
2010	Wyld, D, Milne, RW, Burge, M, Coulthard, A, Cubitta, A, Francesconi, A, Rose, S, Lickliter, J, Yeadon, T, Smith, G, Vasey, P, Wilks, A, McCarron, J & Griffin, M 2010, 'Phase i trial of CYT997, a novel cytotoxic and vascular-disrupting agent', British Journal of Cancer, vol. 103, no. 5, pp. 597-606. Open access 28 24
2009	Ma, Z, Wang, J, Nation, RL, Li, J, Turnidge, JD, Coulthard, K & Milne, RW 2009, 'Renal disposition of colistin in the isolated perfused rat kidney', Antimicrobial Agents and Chemotherapy, vol. 53, no. 7, pp. 2857-2864. Open access 74 72
2009	Turkanovic, J, Ngo, SN & Milne, RW 2009, 'Effect of St John's wort on the disposition of fexofenadine in the isolated perfused rat liver', Journal of Pharmacy and Pharmacology, vol. 61, no. 8, pp. 1037-1042. 5 4
2008	Davies, B, Herbert, M, Coller, J, Somogyi, A, Milne, RW & Sallustio, B 2008, 'Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline', British Journal of Clinical Pharmacology, vol. 65, no. 3, pp. 347-354. Open access 8 8
2008	Li, J, Nation, R, Bergen, P, Milne, RW, Coulthard, K & Turnidge, J 2008, 'Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model', Journal of Antimicrobial Chemotherapy, vol. 61, no. 3, pp. 636-642. Open access 120 110
2008	Ma, Z, Gerber, JP, Milne, RW & Wang, J 2008, 'Determination of colistin in human plasma, urine and other biological samples using LC-MS/MS', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 862, no. 1-2, pp. 205-212. 58 55
2008	Milne, RW, Li, J, Middleton, D, Nation, R, Coulthard, K, Taylor, DK, Turnidge, J, Wallace, S & Rayner, C 2008, 'Subacute toxicity of colistin methanesulfonate in rats: Comparison of various intravenous dosage regimens', Antimicrobial Agents and Chemotherapy, vol. 52, no. 3, pp. 1159-1161. Open access 67 65
2008	Milne, RW, Wiese, MD, Heddle, R, Chataway, T, Davies, N & Brown, S 2008, 'Myrmecia pilosula (Jack Jumper) ant venom: Validation of a procedure to standardise an allergy vaccine', Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 1, pp. 58-65. 17 14

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Cardiff University	UNITED KINGDOM
Charles Darwin University	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Cytopia Research Pty Ltd	AUSTRALIA
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Garvan Institute of Medical Research	AUSTRALIA
Monash Medical Centre	AUSTRALIA
Monash University	AUSTRALIA
Murdoch University	AUSTRALIA
Open University	UNITED KINGDOM
Queensland Institute of Medical Research	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Brisbane and Women's Hospital	AUSTRALIA
Royal Zoological Society of SA	AUSTRALIA
Shandong University	CHINA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
The Queen Elizabeth Hospital	AUSTRALIA
University of Adelaide	AUSTRALIA
University of Melbourne	AUSTRALIA
University of Nottingham	UNITED KINGDOM
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Southampton	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Tasmania	AUSTRALIA
University of Western Australia	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

Teaching & student supervision

Highlights

Dosage Form Design (the science behind the design of dosage forms for administering drugs),Pharmacokinetics and Biopharmaceutics (a course which studies the fate of drugs in the body and how long they remain in the body)

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Development of Cyclin Dependent Kinase Inhibitors for Cancer Treatment	Current
Identification of the mechanism of resistance against PI3K inhibitors in human leukemia	Current
Design, synthesis, and evaluation of novel CDK2 inhibitors as potential anticancer agents	Completed
Developing inhibitorsof MAP kinase-interacting kinases as potential anti-cancer agents	Completed
Development of cyclin dependent kinase 9 inhibitors for the treatment of cancer	Completed
Discovery and evaluation of MNK inhibitors as potential anti-cancer agents	Completed
Effect of garlic and ginkgo extracts on the pharmacokinetics of fexofenadine: a mechanistic study	Completed
Novel cyclin-dependent kinase 9 inhibitors for the treatment of cancer: identification and preclinical evaluation	Completed
Pharmacokinetic interaction between morphine and ketamine	Completed
Pharmacological evaluation of protein kinase inhibitors as anti-cancer agents	Completed
Population-based models of the effect of food and pH on oral drug absorption	Completed
Pre-clinical development of a CDK inhibitor for the treatment of cancer	Completed
Pre-clinical Evaluation of FLT3 Inhibitors for Treatment of Acute Myeloid Leukaemia	Completed
Preclinical evaluation of inhibitors of cyclin-dependent kinases 4 and 6 for the treatment of cancer	Completed
Preclinical evaluation of novel dual CDK2/5 inhibitors as anticancer drug candidates	Completed
Preclinical evaluation of TAM kinase inhibitors as potential anticancer agents	Completed
Renal disposition of colistin and colistin methanesulfonate in the isolated perfused rat kidney	Completed
The impact of formulating 5-Fluorouracil into liposomes on its site-specific delivery to tumour tissue	Completed

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Associate Professor Bob Milne

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Chapters

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Other

Teaching & student supervision

Highlights

Courses and programs

Research degree supervision

Gallery