Dr Sally Plush

Senior Lecturer in Chemistry School of Pharmacy and Medical Sciences

City West Campus (HB5-26)
tel +61 8 830 22586

email Sally.Plush@unisa.edu.au

Research Degree Supervisor

About me

My research is aimed at using a mixture of organic and inorganic chemistry to advance knowledge in biology especially around key biological processes I have a background in supramolecular chemistry and the design of macrocyclic luminescent lanthanide sensors for biologically relevant analytes. My current research interests are primarily focussed on the further development of luminescent metal ion complexes (transition and lanthanoid based)for live cell imaging applications. I currently coordinate and teach the first year organic chemistry course; chemistry 101. In addition, I course coordinate a 2nd year organic chemistry course; Synthetic Chemistry. I also lecture and support the following courses; Advanced Synthetic Chemistry, Advanced...

School of Pharmacy and Medical Sciences

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Research

Research themes

Transforming industries
Cancer

Research focus

Inorganic Chemistry
Other Chemical Sciences
Medicinal and Biomolecular Chemistry
Chemical Engineering
Theoretical and Computational Chemistry

Highlights

My research focuses on furthering knowledge in biology and medicine through the development of imaging devices. Non-invasive imaging technologies with the ability to report on internalisation, traffic and localisation in conjunction with changes in the intracellular environment (e.g. pH, enzymolysis) have the capacity to transform the biological sector and related disciplines. Current work focuses on the use of luminescent lanthanide optical probes to study the dynamic processes of subcellular traffic and molecular interactions.,I currently have three PhD students working the development of optical sensors for lysosomal storage disorders, visualisation of chemotherapy agents and the sensing of pharmaceutical metabolites. In addition I...

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2018	Du, Z, Sun, J, Bader, CA, Brooks, DA, Li, M, Li, X & Plush, SE 2018, 'Synthesis, photophysical and cellular characterisation of folate and methotrexate labelled luminescent lanthanide complexes', Journal of inorganic biochemistry, vol. 178, pp. 32-42. 1
2018	Gillam, TA, Sweetman, MJ, Bader, CA, Morrison, JL, Hayball, JD, Brooks, DA & Plush, SE 2018, 'Bright lights down under: Metal ion complexes turning the spotlight on metabolic processes at the cellular level', Coordination chemistry reviews, online, pp. 1-22.
2018	Morrison, JL, Sorvina, A, Darby, JR, Bader, CA, Lock, MC, Seed, M, Kuchel, T, Plush, SE & Brooks, DA 2018, 'Label-free imaging of redox status and collagen deposition showing metabolic differences in the heart', Journal of biophotonics, vol. 11, no. 3, article no. e201700242, pp. 1-7. 1 4
2018	Sorvina, A, Bader, C, Lock, MC, Brooks, DA, Morrison, JL & Plush, SE 2018, 'Label-free imaging of healthy and infarcted fetal sheep hearts by two-photon microscopy', Journal of biophotonics, vol. 11, no. 1, article no. e201600296, pp. 1-8. Open access 1 4
2018	Sweetman, MJ, Sebben, D, Noll, BD, Wang, WH, May, S, Mebberson, N, Plush, SE & Hayball, JD 2018, 'A rapid technique to determine performance and efficiency of activated carbon water filters', Water science and technology: water supply, vol. 18, no. 2, pp. 371-382.
2017	Caporale, C, Bader, CA, Sorvina, A, Magee, KD, Skelton, BW, Gillam, TA, Wright, PJ, Raiteri, P, Stagni, S, Morrison, JL, Plush, SE, Brooks, DA & Massi, M 2017, 'Investigating intracellular localisation and cytotoxicity trends for neutral and cationic iridium tetrazolato complexes in live cells', Chemistry - a European journal, vol. 23, no. 62, pp. 15666-15679. 6 5 14
2017	Farashishiko, A, Maier, KB, Plush, SE, Sherry, AD & Woods, M 2017, 'Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities', Chemical communications, vol. 53, no. 47, pp. 6355-6358. 1 2 4
2017	Jenie, SA, Hickey, SM, Du, Z, Sebben, D, Brooks, DA, Voelcker, NH & Plush, SE 2017, 'A europium-based 'off-on' colourimetric detector of singlet oxygen', Inorganica chimica acta, vol. 462, pp. 236-240. 1 1 3
2017	Jenie, SA, Plush, SE & Voelcker, NH 2017, 'Singlet oxygen detection on a nanostructured porous silicon thin film via photonic luminescence enhancements', Langmuir, vol. 33, no. 35, pp. 8606-8613. 1
2017	Sinha, S, Tong, WY, Williamson, NH, McInnes, SJ, Puttick, S, Cifuentes-Rius, A, Bhardwaj, R, Plush, SE & Voelcker, NH 2017, 'Novel Gd-loaded silicon nanohybrid: a potential epidermal growth factor receptor expressing cancer cell targeting magnetic resonance imaging contrast agent', ACS applied materials and interfaces, vol. 9, no. 49, pp. 42601-42611. 1 1
2017	Stevens, K, Bader, C, Sorvina, A, Plush, S & Morrison, J 2017, 'Imaging and lipidomics methods for lipid analysis in metabolic and cardiovascular disease', Journal of developmental origins of health and disease, vol. 8, no. 5, pp. 566-574. 1 1
2017	Sweetman, MJ, May, S, Mebberson, N, Pendleton, P, Vasilev, K, Plush, SE & Hayball, J 2017, 'Activated carbon, carbon nanotubes and graphene: materials and composites for advanced water purification', Journal of carbon research, vol. 3, no. 2, pp. 1-29. Open access
2017	Wedding, J, Harris, H, Bader, C, Plush, S, Mak, R, Massi, M, Brooks, D, Lai, B, Vogt, S, Werrett, M, Simpson, P, Skelton, B & Stagni, S 2017, 'Intracellular distribution and stability of a luminescent rhenium(I) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with x-ray fluorescence imaging', Metallomics, online pp. 1-9. 2 4 9
2016	Bader, C, Carter, E, Safitri, A, Simpson, P, Wright, P, Stagni, S, Massi, M, Lay, P, Brooks, D & Plush, S 2016, 'Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes', Molecular biosystems, vol. 12, no. 7, pp. 2064-2068. Open access 7 7 6
2016	Bader, CA, Shandala, T, Carter, EA, Ivask, A, Guinan, T, Hickey, SM, Werrett, M V, Wright, PJ, Simpson, P V, Stagni, S, Voelcker, NH, Lay, PA, Massi, M, Plush, SE & Brooks, DA 2016, 'A molecular probe for the detection of polar lipids in live cells', PLOS one, vol. 11, no. 8, pp. 1-24. Open access 7 6 14
2016	Bader, CA, Sorvina, A, Simpson, P V, Wright, PJ, Stagni, S, Plush, SE, Massi, M & Brooks, DA 2016, 'Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time', FEBS letters, vol. 590, no. 18, pp. 3051-3060. Open access 5 5 8
2016	Jenie, SA, Plush, SE & Voelcker, NH 2016, 'Recent advances on luminescent enhancement-based porous silicon biosensors', Pharmaceutical research, vol. 33, no. 10, pp. 2314-2336. 5 5 1
2015	Fanning, A-M, Plush, SE & Gunnlaugsson, T 2015, 'Tri- and tetra-substituted cyclen based lanthanide(III) ion complexes as ribonuclease mimics: a study into the effect of log Ka, hydration and hydrophobicity on phosphodiester hydrolysis of the RNA-model 2-hydroxypropyl-4-nitrophenyl phosphate (HPNP)', Organic and biomolecular chemistry, vol. 13, pp. 5804-5816. 2 2 1
2014	Bader, CA, Brooks, RD, Ng, YS, Sorvina, A, Werrett, M V, Wright, PJ, Anwer, AG, Brooks, DA, Stagni, S, Muzzioli, S, Silberstein, M, Skelton, BW, Goldys, EM, Plush, SE, Shandala, T & Massi, M 2014, 'Modulation of the organelle specificity in Re(i) tetrazolato complexes leads to labeling of lipid droplets', RSC advances, vol. 4, no. 31, pp. 16345-16351. 22 22
2014	Du, Z, Borlace, GN, Brooks, RD, Butler, RN, Brooks, DA & Plush, SE 2014, 'Synthesis and characterisation of folic acid based lanthanide ion probes', Inorganica Chimica Acta, vol. 410, pp. 11-19. 2 2 1
2014	Jenie, AS, Du, Z, McInnes, SJ, Ung, P, Graham, B, Plush, SE & Voelcker, N 2014, 'Biomolecule detection in porous silicon based microcavities via europium luminescence enhancement', Journal of materials chemistry B, vol. 2 no. 44, pp. 7694-7703. Open access 8 7
2014	Jenie, SA, Pace, S, Sciacca, B, Brooks, RD, Plush, SE & Voelcker, N 2014, 'Lanthanide luminescence enhancements in porous silicon resonant microcavities', ACS applied materials and interfaces, vol. 6, no. 15, pp. 12012-12021. 19 18 3
2014	Plush, SE & Kehrwald, BA 2014, 'Supporting new academics' use of student centred strategies in traditional university teaching', Journal of university teaching and learning practice, vol. 11, no. 1, article no. 5, pp. 1-16.
2013	Brooks, RD, Du, Z, Borlace, G, Brooks, D & Plush, S 2013, 'Synthesis and characterisation of first generation luminescent lanthanide complexes suitable for being adapted for uptake via the mannose receptor', Journal of inorganic chemistry, vol. 2013, pp. 1-8. Open access 1
2010	Plush, SE, Clear, NA, Leonard, JP, Fanning, A-M & Gunnlaugsson, T 2010, 'The effect on the lanthanide luminescence of structurally simple Eu(III) cyclen complexes upon deprotonation of metal bound water molecules and amide based pendant arms', Dalton Transactions, vol. 39, no. 15, pp. 3644-3652. 15 15
2008	Plush, SE & Gunnlaugsson, T 2008, 'Solution studies of trimetallic lanthanide luminescent anionn sensors: towards ratiometric sensing using an internal reference channel', Dalton Transactions, vol. 29, pp. 3801-3804. 55 53

Conferences

Year	Output
2017	Zhang, WQ, Morrison, JL, Darby, JR, Plush, S, Sorvina, A, Brooks, D, Monro, TM & Afshar Vahid, S 2017, 'A fibre optic fluorescence sensor to measure redox level in tissues', Nanophotonics Australasia 2017, SPIE, vol. 10456, article no. 104564R, pp. 1-6.

Research

Patents

Details	Registry	Status
Complexes for intracellular imaging Brooks, Douglas; Massimilio, Massimilio; Plush, Sally; Stagni, Stefano	WO	Filed
Iridium complexes for intracellular imaging Brooks, Doug; Massimiliano, Massimiliano; Plush, Sally; Stagni, Stefano	WO	Filed
Methods and products for labelling lipids Brooks, Douglas; Massi, Massimilio; Plush, Sally	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Argonne National Laboratory	UNITED STATES
Curtin University	AUSTRALIA
Flinders University	AUSTRALIA
Macquarie University	AUSTRALIA
Monash University	AUSTRALIA
Portland State University	UNITED STATES
Puratap	AUSTRALIA
Puratap Pty Ltd	AUSTRALIA
Shandong University	CHINA
SickKids Research Institute	CANADA
Trinity College Dublin	IRELAND
University of Adelaide	AUSTRALIA
University of Bologna	ITALY
University of Dublin	IRELAND
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Texas	UNITED STATES
University of Toronto	CANADA
University of Western Australia	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Citations for Outstanding Contributions to Student Learning Department of Education and Training	2017

Other

MRACI member, Scientists in Schools

Teaching & student supervision

Highlights

Organic Chemistry,Fluorescence,Nuclear and Magnetic Resonance Spectroscopy,Inorganic Chemistry,Bioinorganic Chemistry

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Development of a fast efficient and robust bioconjugation strategy	Current
Improving cancer targeting through the use of highly luminescent metal ions of Re (I)	Current
Novel pH responsive mesoporous nanoparticles for targeting the co-delivery of anticancer agents to multidrug resistant cancer cells	Current
Targeted Luminescent metal ion complexes as probes for live cell imaging	Current
Atg9 and the visualisation of autophagic compartments	Completed
Development of targeted luminescent metal complexes for cellular imaging	Completed
Luminescence sensing based on Tb(III) and Eu(III) macrocyclic complexes to monitor drug metabolites in urine	Completed
Study of luminescence enhancement by porous silicon microcavities for biosensing applications	Completed
Synthesis and characterisation of folate and methotrexate labelled luminescent lanthanide complexes	Completed

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Dr Sally Plush

About me

About me

School of Pharmacy and Medical Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Journal Articles

Conferences

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Citations for Outstanding Contributions to Student Learning

Other

Teaching & student supervision

Highlights

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

Gallery