Professor Sharad Kumar

Chair of Cancer Biology/Research Professor of Cell Biology Centre for Cancer Biology

City West Campus (HB11-13)
tel +61 8 830 27918

email Sharad.Kumar@unisa.edu.au

Alternative contact

Research Degree Supervisor

About me

"I am among those who think that science has great beauty." Marie Curie

I am a NHMRC Senior Principal Research Fellow, a co-Director of the Centre for Cancer Biology, and hold the Chair of Cancer Biology and Research Professorship of Cell Biology.

After completing a PhD from University of Adelaide and postdoctoral training at University of Queensland, I held research scientist/staff positions at CSIRO (Geelong), RIKEN (Tsukuba, Japan), and the Cancer Institute (Tokyo, Japan), before returning to Adelaide to start a research program at the Hanson Centre for Cancer Research at IMVS (which later became SA Pathology). In 2009, with Angel Lopez, I co-founded the Centre for Cancer Biology (CCB) within SA Pathology. The CCB, now an alliance... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

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Orcid

About me

"I am among those who think that science has great beauty." Marie Curie

I am a NHMRC Senior Principal Research Fellow, a co-Director of the Centre for Cancer Biology, and hold the Chair of Cancer Biology and Research Professorship of Cell Biology.

I am a passionate about science! I have been trained as a biochemist, molecular biologist and cell biologist. My current research interests are in molecular and cellular biology of disease, including cancer biology. The work of my team has resulted in fundamental discoveries in two key fields of intense contemporary interest: cell death and ubiquitin-dependent protein modification. Some of our key discoveries include the Nedd genes, e.g. identification of one of the first mammalian caspases (caspase-2); a novel family of ubiquitin ligases (the Nedd4 family); and the ubiquitin-like protein Nedd8 involved in a novel protein-modification process, now widely known as Neddylation. We also discovered and characterised a large part of the Drosophila cell death machinery, identified Ndfip1 and Ndfip2 as adaptors/regulators of ubiquitin ligases and defined a previously unknown autophagy-dependent cell death program during development. Our work has resulted in groundbreaking contributions to the understanding of many human ailments including cancer, cardiovascular and kidney diseases.

I am a Fellow of the Australian Academy of Science (FAA), as well as a Fellow of the Australian Academy of Health and Medical Sciences (FAHMS). My contributions to biomedical research have also been recognised through a Wellcome Trust (UK) Senior Fellowship in Medical Sciences, the ASBMB Amersham Biosciences Award, the Ranbaxy Research Award, the Lemberg Medal of ASBMB, the FAOBMB Research Excellence Award and the ANZSCDB President's Medal. On Australia Day 2018 I was appointed a Member of the Order of Australia in the General Division, for “significant service to medical research in the field of cancer and cell biology, as a scientist and author, to medical education, and as a mentor”.

Our work has been published in 255 articles, cited over 32,000 times with a current h index of 86 (Google Scholar), and presented in over 230 invited international and national talks and seminars. I have had the privilege of mentoring 30 postdoctoral scientists and 22 PhD students.

Research

Research themes

Cancer
Healthy futures

Research focus

Biochemistry and Cell Biology
Medical and Health Sciences
Biological Sciences
Clinical Sciences
Oncology and Carcinogenesis

Highlights

Cancer Biology

Cell Death

Ubiquitination

Disease models and mechanisms

Cellular and molecular biology

Research

Projects

Excludes commercial-in-confidence projects.

Ubiquitination-regulated sodium homeostasis in kidney disease, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Deciphering the mechanisms of caspase-2-mediated suppression of aneuploidy and tumourigenesis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2020
Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer, NHMRC - Project Grant, 01/01/2018 - 31/12/2020
Cell death by self-eating: understanding autophagy-dependent tissue removal, ARC - Discovery Projects, 13/01/2017 - 12/01/2020
Exploring the role of Arrcd4 in extracellular vesicle biogenesis and its implications in tissue homeostasis, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Hormone-dependent autophagy and growth signalling in developmental cell death, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Nedd4-2: a new player in polycystic kidney disease, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Deciphering the function of capcase-2 in DNA damage response and tumour suppression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
Post-translational control of cell fate decision, ARC - Discovery Projects, 01/01/2015 - 31/12/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
NHMRC Equip 2015 - SynergyHT fluorescence and UV/Vis 96-well plate reader for high throughput nucleic acid quantification via picogreen, NHMRC - Equipment Only Grants, 01/01/2016 - 31/12/2016
Autophagy and growth signalling in developmentally programmed cell death, NHMRC - Project Grant, 01/01/2014 - 31/12/2016
A novel mechanism for regulating membrane proteins by ubiquitin ligases and their adaptors, NHMRC - Project Grant, 01/01/2014 - 31/12/2016
Understanding the role of capcase-2 in cellular stress response and ageing, NHMRC - Project Grant, 06/03/2014 - 31/12/2016
Deciphering the mechanisms of a caspase-mediated tumour suppressor pathway, Worldwide Cancer Research (formerly - Association for International Cancer Research), 01/06/2013 - 31/08/2016
Physiological function of Nedd4-2 in regulating the epithelial sodium channel and cystic fibrosis transmembrane conductance regulator, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
NHMRc Equipment Grant 2014: ChemiDoc MP system, NHMRC - Equipment Only Grants, 01/01/2015 - 31/12/2015
Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2015
NHMRC Equipment Grant 2014: Eppendorf Nexus Gradient PCR, NHMRC - Equipment Only Grants, 01/01/2015 - 31/12/2015

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID

Open access indicates that an output is open access.

Highlights

Year	Output
2014	Shalini, S, Dorstyn, L, Dawar, S & Kumar, S 2014, 'Old, new and emerging functions of caspases', Cell Death and Differentiation, vol. 22, no. 4, pp. 526-539. Open access 243 308 1
2013	Puccini, J, Shalini, S, Voss, A, Gatei, M, Wilson, C, Hiwase, D, Lavin, M, Dorstyn, L & Kumar, S 2013, 'Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 49, pp. 19920-19925. Open access 34 36 16
2011	Boase, NA, Rychkov, G, Townley, S, Dinudom, A, Candi, E, Voss, A, Tsoutsman, T, Semsarian, C, Melino, G, Koentgen, F, Cook, D & Kumar, S 2011, 'Respiratory distress and perinatal lethality in Nedd4-2-deficient mice', Nature Communications, vol. 2, no. 287, pp. 1-9. Open access 53 49 3

Chapters

Year	Output
2013	Dorstyn, L & Kumar, S 2013, 'Insect caspases', in Alan Barrett, Neil Rawlings & J Woessner (eds), Handbook of proteolytic enzymes, 3, Elsevier, UK, vol. 2, ch. 514, pp. 2286-2295.

Journal Articles

Year	Output
2019	Anand, S, Samuel, M, Kumar, S & Mathivanan, S 2019, 'Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles', BBA: Proteins and Proteomics, online, pp. 1-10. 1 1
2019	Denton, D & Kumar, S 2019, 'Autophagy-dependent cell death', Cell Death and Differentiation, vol. 26, pp. 605-616. 10 5 8
2019	Denton, D, Xu, T, Dayan, S, Nicolson, S & Kumar, S 2019, 'Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation', Cell Death and Disease, vol. 10, no. 2, article no. 111, pp. 1-8. Open access 2 5
2019	Denton, D, Xu, T, Dayan, S, Nicolson, S & Kumar, S 2019, 'Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production', Cell Death and Differentiation, vol. 26, pp. 763-778. Open access 7 6 4
2019	Dorstyn, L, Hackett-Jones, E, Nikolic, A, Norris, MD, Lim, Y, Toubia, J, Haber, M & Kumar, S 2019, 'Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling', Cell Death and Disease, vol. 10, no. 2, pp. 1-16. Open access 5
2018	Anand, S, Foot, N, Ang, C-S, Gembus, KM, Keerthikumar, S, Adda, CG, Mathivanan, S & Kumar, S 2018, 'Arrestin‐domain containing protein 1 (Arrdc1) regulates the protein cargo and release of extracellular vesicles', Proteomics, vol. 18, no. 17, article no. 1800266, pp. 1-16. 5 4 1
2018	Dorstyn, L, Akey, CW & Kumar, S 2018, 'New insights into apoptosome structure and function', Cell Death and Differentiation, vol. 25, pp. 1194-1208. Open access 5 5 13
2018	Galluzzi, L, Vitale, I, Aaronson, S, Abrams, J, Kumar, S & Kroemer, G and 163 other authors 2018, 'Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018', Cell Death and Differentiation, vol. 25, no. 3, pp. 486-541. Open access 290 262 102
2018	Lim, Y, De Bellis, D, Dorstyn, L & Kumar, S 2018, 'p53 accumulation following cytokinesis failure in the absence of caspase-2', Cell Death and Differentiation, online, pp. 1-3. Open access 3
2018	Manning, JA & Kumar, S 2018, 'Physiological functions of Nedd4-2: lessons from knockout mouse models', Trends in Biochemical Sciences, vol. 43, no. 8, pp. 635-647. 3 2 2
2018	Wilson, CH & Kumar, S 2018, 'Caspases in metabolic disease and their therapeutic potential', Cell Death and Differentiation, vol. 25, no. 6, pp. 1010-1024. 7 7 15
2018	Xu, T, Denton, D & Kumar, S 2018, 'Hedgehog and wingless signaling are not essential for autophagy-dependent cell death', Biochemical Pharmacology, online, pp. 1-11. 2 2 4
2017	Foot, NJ, Henshall, T & Kumar, S 2017, 'Ubiquitination and the regulation of membrane proteins', Physiological Reviews, vol. 97, no. 1, pp. 253-281. 31 31 2
2017	Galluzzi, L, Baehrecke, EH, Ballabio, A, Boya, P, Kumar, S & Kroemer, G 2017, 'Molecular definitions of autophagy and related processes', The EMBO Journal, vol. 36, no. 13, pp. 1811-1836. 249 245 74
2017	Henshall, TL, Manning, JA, Alfassy, OS, Goel, P, Boase, N, Kawabe, H & Kumar, S 2017, 'Deletion of Nedd4-2 results in progressive kidney disease in mice', Cell Death and Differentiation, vol. 24, pp. 2150-2160. Open access 2 2 2
2017	Wilson, CH, Nikolic, A, Kentish, SJ, Keller, M, Hatzinikolas, G, Dorstyn, L, Page, AJ & Kumar, S 2017, 'Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity', Cell Death and Disease, vol. 8, article no. e3136, pp. 1-12. Open access 4 4 2
2017	Xu, T, Kumar, S & Denton, D 2017, 'Characterization of autophagic responses in drosophila melanogaster', Methods in Enzymology, vol. 588, pp. 445-465. 5 5
2016	Camera, D, Coleman, HA, Parkington, HC, Jenkins, TA, Pow, D V, Boase, NA, Kumar, S & Poronnik, P 2016, 'Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice', Behavioural Brain Research, vol. 303, pp. 176-181. 4 5 4
2016	Dawar, S, Lim, Y, Puccini, J, White, M, Thomas, P, Bouchier-Hayes, L, Green, D, Dorstyn, L & Kumar, S 2016, 'Caspase-2-mediated cell death is required for deleting aneuploid cells', Oncogene, vol. 36, no. 19, pp. 2704-2714. Open access 19 18 10
2016	Dawar, S, Shahrin, NH, Sladojevic, N, D'Andrea, R, Dorstyn, L, Hiwase, DK & Kumar, S 2016, 'Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice', Cell Death and Disease, vol. 7, no. e2509, pp.1-9. Open access 10 9 10
2016	Foot, NJ, Gembus, KM, Mackenzie, K & Kumar, S 2016, 'Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver', Scientific Reports, vol. 6, article no. 24045, pp. 1-9. Open access 3 3
2016	Galluzzi, L, López-Soto, A, Kumar, S & Kroemer, G 2016, 'Caspases connect cell-death signaling to organismal homeostasis', Immunity, vol. 44, no. 2, pp. 221-231. 109 95 5
2016	Klionsky, D, Abdelmohsen, K, Abe, A, Abedin, MJ, Kumar, S, Morrison, JL & Zughaier, SM and 2460 other authors 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, vol. 12, no. 1, pp. 1-222. 1920 1926 331
2016	Shalini, S, Nikolic, A, Wilson, C, Puccini, J, Sladojevic, N, Finnie, J, Dorstyn, L & Kumar, S 2016, 'Caspase-2 deficiency accelerates chemically induced liver cancer in mice', Cell Death and Differentiation, vol. 23, pp.1727-1736. Open access 11 12 10
2016	Wilson, C, Nikolic, A, Kentish, S, Shalini, S, Hatzinikolas, G, Page, A, Dorstyn, L & Kumar, S 2016, 'Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice', Cell Death Discovery, online, vol.2, article no. 16009, pp. 1-10. Open access 9 1
2016	Yip, K-H, Kolesnikoff, N, Hauschild, N, Biggs, L, Lopez, AF, Galli, SJ, Kumar, S & Grimbaldeston, MA 2016, 'The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation', Nature Communications, vol. 7, article no.13198, pp. 1-14. Open access 2 2
2015	Boase, NA & Kumar, S 2015, 'NEDD4 : the founding member of a family of ubiquitin-protein ligases', Gene, vol. 557, no. 2, pp. 113-122. 44 46
2015	Denton, D & Kumar, S 2015, 'Analyzing the response of RNAI-treated drosophila cells to death stimuli by quantitative real-time polymerase chain reaction', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 666-671. 1 8
2015	Denton, D & Kumar, S 2015, 'Immunostaining using an antibody against active caspase-3 to detect apoptotic cells in drosophila', Cold Spring Harbor Protocols, vol. 6, pp. 576-579. 3 1
2015	Denton, D & Kumar, S 2015, 'Studying apoptosis in Drosophila', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 609-613. 4 1
2015	Denton, D & Kumar, S 2015, 'Terminal deoxynucleotidyl transferase (TdT)-mediated dutp nick-end labeling (TUNEL) for detection of apoptotic cells in Drosophila', Cold Spring Harbor Protocols. 4 1
2015	Denton, D & Kumar, S 2015, 'Using synthetic peptide substrates to measure Drosophila caspase activity', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 671-674. 1 1
2015	Denton, D & Kumar, S 2015, 'Using the vital dye acridine orange to detect dying cells in drosophila', Cold Spring Harbor Protocols, vol. 6, pp. 572-574. 3 1
2015	Denton, DM, Xu, T & Kumar, S 2015, 'Autophagy as a pro-death pathway', Immunology and Cell Biology, vol. 93, pp. 35-42. 93 89 2
2015	Galluzi, L, Bravo-San, PJ, Vitale, I, Aaaronson, S, Kumar, S & Kroemer, G and 102 other authors 2015, 'Essential versus accessory aspects of cell death: recommendations of the NCCD 2015', Cell Death and Differentiation, vol. 22, pp. 58-73. Open access 435 413 23
2015	Galluzzi, L, Pietrocola, F, Bravo-San, PJM, Amaravadi, RK, Kumar, S & Kroemer, G and 18 other authors 2015, 'Autophagy in malignant transformation and cancer progression', The EMBO Journal, vol. 34, no. 7, pp. 856-880. Open access 443 430 45
2015	Goel, P, Manning, JA & Kumar, S 2015, 'NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins', Gene, vol. 557, no. 1, pp. 1-10. 39 37 2
2015	Nicolson, S, Denton, D & Kumar, S 2015, 'Ecdysone-mediated programmed cell death in Drosophila', International Journal of Developmental Biology, vol. 59, vol. 1, pp. 23-32. Open access 9 8 1
2015	Peintner, L, Dorstyn, L, Kumar, S, Aneichyk, T, Villunger, A & Manzl, C 2015, 'The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd', Cell Death and Differentiation, vol. 22, pp. 1803-1811. Open access 11 11 7
2015	Wilson, C, Shalini, S, Filipovska, A, Richman, T, Davies, S, Martin, S, McGee, S, Puccini, J, Nikolic, A, Dorstyn, L & Kumar, S 2015, 'Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice', Cell Death and Disease, vol. 6, article no. e1597, pp. 1-31. Open access 15 17 10
2015	Xu, T, Nicolson, S, Denton, D & Kumar, S 2015, 'Distinct requirements of Autophagy-related genes in programmed cell death', Cell Death and Differentiation, vol. 20, no. 11, pp. 1792-1802. Open access 16 21 13
2014	Altin, JA, Daley, SR, Howitt, J, Rickards, HJ, Batkin, AK, Horikawa, K, Prasad, S, Nelms, KA, Kumar, S, Wu, LC, Tan, S-S, Cook, MC & Goodnow, CC 2014, 'Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 6, pp. 2067-2074. Open access 9 11 1
2014	Camera, D, Boase, NA, Kumar, S, Pow, D V & Poronnik, P 2014, 'Subtle gait abnormalities in Nedd4 heterozygous mice', Behavioural Brain Research, vol. 260, pp. 15-24. 7 7
2014	Dorstyn, L & Kumar, S 2014, 'Caspase-2 protocols', Methods in Molecular Biology, vol. 1133, pp. 71-87. 2
2014	Dorstyn, L, Puccini, J, Nikolic, A, Shalini, S, Wilson, C, Norris, M, Haber, M & Kumar, S 2014, 'An unexpected role for caspase-2 in neuroblastoma', Cell Death and Disease, vol. 5, article no. e1383, pp. 1-9. Open access 9 9 1
2014	Ekberg, JA, Boase, NA, Rychkov, G, Manning, J, Poronnik, P & Kumar, S 2014, 'Nedd4-2 (NEDD4L) controls intracellular Na+-mediated activity of voltage-gated sodium channels in primary cortical neurons', Biochemical Journal, vol. 457, no. 1, pp. 27-31. Open access 18 18 2
2014	Sandow, J, Dorstyn, L, O'Reilly, L, Tailler, M, Kumar, S, Strasser, A & Ekert, P 2014, 'ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis', Cell Death and Differentiation, vol. 21, pp. 475-480. Open access 33 31 1
2014	Shalini, S, Dorstyn, L, Dawar, S & Kumar, S 2014, 'Old, new and emerging functions of caspases', Cell Death and Differentiation, vol. 22, no. 4, pp. 526-539. Open access 243 308 1
2014	Shalini, S, Puccini, J, Wilson, CH, Finnie, J, Dorstyn, LE & Kumar, S 2014, 'Caspase-2 protects against oxidative stress in vivo', Oncogene, vol. 34, no. 38, pp. 4995-5002. 14 15 1
2013	Denton, D, Aung-Htut, MT & Kumar, S 2013, 'Developmentally programmed cell death in Drosophila', BBA: Molecular Cell Research, vol. 1833, no. 12, pp. 3499-3506. Open access 31 32 1
2013	Denton, D, Aung-Htut, MT, Lorensuhewa, N, Nicolson, S, Zhu, W, Mills, K, Cakouros, D, Bergmann, A & Kumar, S 2013, 'UTX coordinates steroid hormone-mediated autophagy and cell death', Nature Communications, vol. 4, article no. 2916, pp. 1-11. 27 26 1
2013	Liu, P, Xu, N, Malyukova, A, Scarlett, C, Kumar, S & Liu, T and 16 other authors 2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, vol. 20, pp. 503-514. 99 90 3
2013	Puccini, J, Dorstyn, L & Kumar, S 2013, 'Caspase-2 as a tumour suppressor', Cell Death and Differentiation, vol. 20, no. 9, pp. 1133-1139. Open access 49 48 1
2013	Puccini, J, Shalini, S, Voss, A, Gatei, M, Wilson, C, Hiwase, D, Lavin, M, Dorstyn, L & Kumar, S 2013, 'Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 49, pp. 19920-19925. Open access 34 36 16
2013	Ronzaud, C, Loffing-Cueni, D, Hausel, P, Debonneville, A, Malsure, SR, Fowler-Jaeger, N, Boase, NA, Perrier, R, Maillard, M, Yang, B, Stokes, JB, Koesters, R, Kumar, S, Hummler, E, Loffing, J & Staub, O 2013, 'Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension', Journal of Clinical Investigation, vol. 123, no. 2, pp. 657-665. 70 75 23
2013	Scheffner, M & Kumar, S 2013, 'Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects', BBA: Molecular Cell Research, vol. 1843, no. 1, pp. 61-74. Open access 107 105 6
2013	Wiszniak, S, Kabbara, E, Lumb, R, Scherer, M, Secker, G, Harvey, N, Kumar, S & Schwarz, Q 2013, 'The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties', Developmental Biology, vol. 383, no. 2, pp. 186-200. Open access 11 12 4
2012	Denton, D, Chang, T-K, Nicolson, S, Shravage, B, Simin, R, Baehrecke, E & Kumar, S 2012, 'Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila', Cell Death and Differentiation, vol. 19, no. 8, pp. 1299-1307. 39 38
2012	Denton, D, Nicolson, S & Kumar, S 2012, 'Cell death by autophagy: facts and apparent artefacts', Cell Death and Differentiation, vol. 19, no. 1, pp. 87-95. 241 235 1
2012	Dorstyn, L, Puccini, J, Wilson, C, Shalini, S, Nicola, M, Moore, S & Kumar, S 2012, 'Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability', Cell Death and Differentiation, vol. 19, no. 8, pp. 1288-1298. 59 59
2012	Galluzzi, L, Vitale, I, Abrams, J, Alnemri, E, Kumar, S & Kroemer, G and 27 other authors 2012, 'Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012', Cell Death and Differentiation, vol. 19, no. 1, pp. 107-120. 1470 1380 17
2012	Garrick, MD, Zhao, L, Roth, JA, Jiang, H, Feng, J, Foot, NJ, Dalton, H, Kumar, S & Garrick, LM 2012, 'Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation', Biometals, vol. 25, no. 4, pp. 787-793. 27 23
2012	Howitt, J, Lackovic, J, Low, L-H, Naguib, A, Macintyre, A, Goh, C-P, Callaway, JK, Hammond, V, Thomas, T, Dixon, M, Putz, U, Silke, J, Bartlett, P, Yang, B, Kumar, S, Trotman, LC & Tan, S-S 2012, 'Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia', The Journal of Cell Biology, vol. 196, no. 1, pp. 29-36. Open access 62 61 1
2012	Klionsky, DJ, Abdalla, FC, Abeliovich, H, Abraham, RT, Denton, D, Kumar, S & Zuckerbraun, B and 1264 other authors 2012, 'Guidelines for the use and interpretation of assays for monitoring autophagy', Autophagy, vol. 8, no. 4, pp. 445-544. 2325 2283 61
2012	Laxmaiah, A, Nair, MK, Nimmathota, A, Raghu, P, Balakrishna, N, Rao, KM, Galreddy, C, Kumar, S, Ravindranath, M, Rao, VV & Brahmam, G 2012, 'Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India', Public Health Nutrition, vol. 15, no. 4, pp. 568-577. Open access 18 15 1
2012	Shalini, S, Dorstyn, L, Wilson, C, Puccini, J, Ho, L & Kumar, S 2012, 'Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice', Cell Death and Differentiation, vol. 19, no. 8, pp. 1370-1380. 44 42
2011	Boase, NA, Rychkov, G, Townley, S, Dinudom, A, Candi, E, Voss, A, Tsoutsman, T, Semsarian, C, Melino, G, Koentgen, F, Cook, D & Kumar, S 2011, 'Respiratory distress and perinatal lethality in Nedd4-2-deficient mice', Nature Communications, vol. 2, no. 287, pp. 1-9. Open access 53 49 3
2011	Dalton, H, Denton, D, Foot, N, Ho, K, Mills, K, Brou, C & Kumar, S 2011, 'Drosophila Ndfip is a novel regulator of Notch signaling', Cell Death and Differentiation, vol. 18, no. 7, pp. 1150-1160. 10 10
2011	Foot, NJ, Leong, YA, Dorstyn, LE, Dalton, HE, Ho, K, Zhao, L, Garrick, MD, Yang, B, Hiwase, D & Kumar, S 2011, 'Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis', Blood, vol. 117, no. 2, pp. 638-646. 25 25
2011	Lee, I-H, Song, S-H, Campbell, CR, Kumar, S, Cook, D I & Dinudom, A 2011, 'Regulation of the epithelial Na⁺ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Gαq/11', Journal of Biological Chemistry, vol. 286, no. 22, pp. 19259-19269. 8 8
2011	Yuan, S, Yu, X, Topf, M, Dorstyn, LE, Kumar, S, Ludtke, S & Akey, C 2011, 'Structure of the drosophila apoptosome at 6.9 A resolution', Structure, vol. 19, no. 1, pp. 128-140. 55 49
2010	Denton, D, Shravage, B V, Simin, R, Baehrecke, EH & Kumar, S 2010, 'Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy', Autophagy, vol. 6, no. 1, pp. 163-165. 39 38
2010	Hiwase, D, White, D, Powell, J, Saunders, V, Zrim, S, Frede, A, Guthridge, M, Lopez, A, D'Andrea, R, To, L, Melo, J, Kumar, S & Hughes, T 2010, 'Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors', Leukemia, vol. 24, no. 4, pp. 771-778. 44 39
2010	Manning, J & Kumar, S 2010, 'A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts', Cell Death and Disease, vol. 1, no. 4, pp. 1-8. 13 13
2010	Manning, J, Lewis, M, Koblar, S & Kumar, S 2010, 'An essential function for the centrosomal protein NEDD1 in zebrafish development', Cell Death and Differentiation, vol. 17, no. 8, pp. 1302-1314. 11 10
2010	Manning, JA, Shalini, S, Risk, J, Day, C & Kumar, S 2010, 'A direct interaction with NEDD1 regulates Gamma-tubulin recruitment to the centrosome', PLoS One, vol. 5, no. 3, pp. 1-12. Open access 27 26 3
2010	Yang, B & Kumar, S 2010, 'Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions', Cell Death and Differentiation, vol. 17, no. 1, pp. 68-77. 124 121 3
2009	Denton, D, Shravage, B, Simin, R, Mills, K, Berry, DL, Baehrecke, EH & Kumar, S 2009, 'Autophagy, not apoptosis, is essential for midgut cell death in Drosophila', Current Biology, vol. 19, no. 20, pp. 1741-1746. 217 218
2009	Dorstyn, L & Kumar, S 2009, 'Putative functions of caspase-2', F1000 Biology Reports, vol. 1, no. 96, pp. 1-5.
2009	Galluzzi, L, Aaronson, S, Abrams, J, Alnemri, E, Kumar, S & Kroemer, G and 73 other authors 2009, 'Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes', Cell Death and Differentiation, vol. 16, pp. 1093-1107. 436 412
2009	Ho, LH, Taylor, R, Dorstyn, L, Cakouros, D, Bouillet, P & Kumar, S 2009, 'A tumor suppressor function for caspase-2', Proceedings of the National Academy of Sciences of USA, vol. 106, no. 13, pp. 5336-5341. 105 101
2009	Howitt, J, Putz, U, Lackovic, J, Doan, A, Dorstyn, L, Cheng, H, Yang, B, Chan-Ling, T, Silke, J, Kumar, S & Tan, S-S 2009, 'Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons', Proceedings of the National Academy of Sciences of USA, vol. 106, no. 36, pp. 15489-15494. Open access 72 71
2009	Kochetkova, M, Kumar, S & McColl, SR 2009, 'Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells', Cell Death and Differentiation, vol. 16, no. 5, pp. 664-673. 61 57
2009	Kroemer, G, Galluzzi, L, Vandenabeele, P, Abrams, J, Kumar, S & Melino, G and 16 other authors 2009, 'Classification of cell death : recommendations of the Nomenclature Committee on Cell Death 2009', Cell Death and Differentiation, vol. 16, no. 1, pp. 3-11. 1748 1651
2009	Kumar, S & Dorstyn, LE 2009, 'Analysing caspase activation and caspase activity in apoptotic cells', Methods in Molecular Biology, vol. 559, pp. 3-17. 13 11
2009	Kumar, S 2009, 'Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?', Nature Reviews Cancer, vol. 9, no. 12, pp. 897-903. 93 92
2009	Lee, I-H, Campbell, CR, Song, S-H, Day, ML, Kumar, S, Cook, D I & Dinudom, A 2009, 'The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism', Journal of Biological Chemistry, vol. 284, no. 19, pp. 12663-12669. Open access 43 39
2009	Rotin, D & Kumar, S 2009, 'Physiological functions of the HECT family of ubiquitin ligases', Nature Reviews Molecular Cell Biology, vol. 10, no. 6, pp. 398-409. Open access 561 537
2008	Cakouros, D, Mills, KM, Denton, DM, Paterson, A, Daish, T & Kumar, S 2008, 'dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes', The Journal of Cell Biology, vol. 182, no. 3, pp. 481-495. Open access 20 18
2008	Cao, X, Lill, N, Boase, NA, Shi, P, Croucher, D, Shan, H, Qu, J, Sweezer, E, Place, T, Kirby, P, Daly, R, Kumar, S & Yang, B 2008, 'Nedd4 controls animal growth by regulating IGF-1 signaling', Science Signaling, vol. 1, no. 38. 104 89
2008	Denton, DM, Mills, KM & Kumar, S 2008, 'Methods and Protocols for Studying Cell Death in Drosophila', Methods in Enzymology, vol. 446, pp. 17-37. 22 20
2008	Dorstyn, LE & Kumar, S 2008, 'A biochemical analysis of the activation of the Drosophila caspase DRONC', Cell Death and Differentiation, vol. 15, no. 3, pp. 461-470. 43 39
2008	Foot, NJ, Dalton, H, Shearwin-Whyatt, L, Dorstyn, LE, Tan, S, Yang, B & Kumar, S 2008, 'Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2', Blood, vol. 112, no. 10, pp. 4268-4275. 84 83
2008	He, Y, Hryciw, D, Carroll, ML, Meyers, S, Whitbread, AK, Kumar, S, Poronnik, P & Hooper, JD 2008, 'The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the tweety family of chloride ion channels', Journal of Biological Chemistry, vol. 283, no. 35, pp. 24000-24010. 20 19
2008	Hiwase, D, Saunders, V, Hewett, D, Frede, A, Zrim, S, Dang, P, Eadie, L, To, L, Melo, J, Kumar, S, Hughes, TP & White, DL 2008, 'Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications', Clinical Cancer Research, vol. 14, no. 12, pp. 3881-3888. 139 125
2008	Ho, L, Read, S, Dorstyn, LE, Lambrusco, L & Kumar, S 2008, 'Caspase-2 is required for cell death induced by cytoskeletal disruption', Oncogene, vol. 27, no. 24, pp. 3393-3404. 87 83
2008	Manning, JA, Colussi, P, Koblar, SA & Kumar, S 2008, 'Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development', Histochemistry and Cell Biology, vol. 129, no. 6, pp. 751-764. 12 13
2008	Putz, U, Howitt, J, Lackovic, J, Foot, NJ, Kumar, S, Silke, J & Tan, S 2008, 'Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins', Journal of Biological Chemistry, vol. 283, no. 47, pp. 32621-32627. 76 73
2008	Schuetz, F, Kumar, S, Poronnik, P & Admas, D 2008, 'Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1', American Journal of Physiology: Cell Physiology, vol. 295, no. 1, pp. 73-80. 18 16

External engagement & recognition

Collaborations

Highlights

International and National Fellowships:

NHMRC Senior Principal Research Fellow (since 2004)

NHMRC Principal Research Fellow

Wellcome Trust (UK) Senior Fellow in Medical Science

Florey Research Fellow

Fellow of the Science and Technology Agency of Japan

University of Queenland Postdoctoral Fellow

Fellowships of the Learned Academies:

Fellow of the Australian Academy of Science (FAA)

Fellow of the Australian Academy of Health and Medical Sciences (FAHMS)

Major Awards and Prizes:

ASBMB Amersham Bioscience Award

Ranbaxy Research Award in Medical Sciences

ASBMB Lemberg Medal

FAOBMB Award for Research Excellence

ANZSCDB President's Medal

Member of the Order of Australia

SAIMA President's Award

External engagement & recognition

Collaborations

Organisation	Country
Australian National University	AUSTRALIA
Baker Heart and Diabetes Institute	AUSTRALIA
Baylor College of Medicine	UNITED STATES
Boston University	UNITED STATES
Centre de Recherche des Cordeliers	FRANCE
Centro de Investigaciones Biológicas	SPAIN
Childrens Cancer Institute Australia for Medical Research	AUSTRALIA
Cold Spring Harbor Laboratory	UNITED STATES
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Deakin University	AUSTRALIA
Emory University	UNITED STATES
Federal University of Sao Carlos	BRAZIL
Federico II University	ITALY
Flinders Medical Centre	AUSTRALIA
Florey Neuroscience Institute	AUSTRALIA
Garvan Institute of Medical Research	AUSTRALIA
Genentech	UNITED STATES
Georgetown University	UNITED STATES
Ghent University	BELGIUM
Griffith University	AUSTRALIA
Hanson Institute	AUSTRALIA
Harry Perkins Institute of Medical Research	AUSTRALIA
Hebrew University	MEXICO
Icahn School of Medicine at Mount Sinai	UNITED STATES
Indian Council of Medical Research	INDIA
Inserm UMR	FRANCE
Institute of Medical and Veterinary Science	AUSTRALIA
Jilin University	CHINA
Karolinska Institute	SWEDEN
La Trobe University	AUSTRALIA
Lausanne University Hospital	FRANCE
Max Planck Institute of Experimental Medicine	GERMANY
Medical University of Innsbruck	AUSTRIA
Monash University	AUSTRALIA
National Institute on Aging	UNITED STATES
Ozgene	AUSTRALIA
Pfizer Worldwide Research and Development	UNITED STATES
Pierre and Marie Curie University	FRANCE
Queensland Institute of Medical Research	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Regina Elena National Cancer Institute	ITALY
Ritsumeikan University	JAPAN
RMIT University	AUSTRALIA
SA Pathology	AUSTRALIA
SA Water Corporation	AUSTRALIA
Sapienza University of Rome	ITALY
St. Jude Children's Research Hospital	UNITED STATES
Stanford University	UNITED STATES
The Hospital for Sick Children	UNITED STATES
The Institut Pasteur (AKA L'Institut Pasteur)	FRANCE
Thomas Jefferson University	UNITED STATES
Tokyo Medical University	JAPAN
Universite Paris	FRANCE
University at Buffalo	UNITED STATES
University of Adelaide	AUSTRALIA
University of Angers	FRANCE
University of Iowa	UNITED STATES
University of Konstanz	GERMANY
University of Lausanne	SWITZERLAND
University of London	UNITED KINGDOM
University of Massachusetts Amherst	UNITED STATES
University of Massachusetts Medical School	UNITED STATES
University of Melbourne	AUSTRALIA
University of Michigan	UNITED STATES
University of Minnesota, Twin Cities	UNITED STATES
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Otago	NEW ZEALAND
University Of Paris Sud (Paris 11)	FRANCE
University of Pennsylvania	UNITED STATES
University of Pittsburgh	UNITED STATES
University of Queensland	AUSTRALIA
University of Rome Tor Vergata	ITALY
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Texas Southwestern Medical Center	UNITED STATES
University of Western Australia	AUSTRALIA
University of Zurich	SWITZERLAND
UT Southwestern Medical Center	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Weill Cornell Medical College	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Fellowship Selection Committee Australian Academy of Science	2020
Member, National Committee for Biomedical Sciences Australian Academy of Science	2020
Fellowship Selection Committee Australian Academy of Science	2019
Member, National Committee for Biomedical Sciences Australian Academy of Science	2019
President Australia and New Zealand Society for Cell and Developmental Biology	2019
Scientist of the year - nomination SA Science Excellence Awards	2019
Affiliate Professor of Medicine University of Adelaide	2018
Associate Editor Molecular and Cellular Oncology	2018
Board member International Cell Death Society	2018
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2018
Editorial Advisory Board Oncotarget	2018
Editorial Board Member Cell Death and Differentiation	2018
Editorial Board Member ScienceOPEN	2018
Editorial Board Member Frontiers in Cancer Molecular Targets and Therapeutics	2018
Fellowship Selection Committee Australian Academy of Science	2018
Finalist, South Australian Scientist of the Year Award Government of South Australia	2018
Member American Society for Biochemistry and Molecular Biology	2018
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2018
Member European Cell Death Organization	2018
Member Japan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA)	2018
Member Faculty of 1000	2018
Member Research Strategy Group of the Beat Cancer Project	2018
Member of the Order of Australia (AM) Order of Australia Foundation Ltd	2018
Member, National Committee for Biomedical Sciences Australian Academy of Science	2018
President Australia and New Zealand Society for Cell and Developmental Biology	2018
SAIMA President Award South Australian Indian Medical Association (SAIMA)	2018
Affiliate Professor of Medicine University of Adelaide	2017
Associate Editor Molecular and Cellular Oncology	2017
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2017
Editorial Advisory Board Oncotarget	2017
Editorial Board Member Cell Death and Differentiation	2017
Editorial Board Member ScienceOPEN	2017
Editorial Board Member Frontiers in Cancer Molecular Targets and Therapeutics	2017
Fellowship Selection Committee Australian Academy of Science	2017
Member American Society for Biochemistry and Molecular Biology	2017
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2017
Member European Cell Death Organization	2017
Member Japan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA)	2017
Member Faculty of 1000	2017
Member Research Strategy Group of the Beat Cancer Project	2017
Member, National Committee for Biomedical Sciences Australian Academy of Science	2017
President Australia and New Zealand Society for Cell and Developmental Biology	2017
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2017
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2016
President's Medal Australia and New Zealand Society for Cell and Developmental Biology	2016
Senior Principal Research Fellowship National Health and Medical Research Council (NHMRC)	2016
Fellow Australian Academy of Health and Medical Science	2015
Fellowship Australia and New Zealand Society for Cell and Developmental Biology	2015
Member, Grant Reviewing Panels National Health and Medical Research Council (NHMRC)	2015
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2015
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2014
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2013
Lamberg Medal Australian Society for Biochemistry and Molecular Biology (ASBMB)	2013
Member of learned academy Australian Academy of Science	2013
Research Excellence Federation of Asian and Oceanian Biochemists and Molecular Biologists	2013
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2012

Other

Editorial Boards, Advisory Committees and Peer Review Panels:

Member, RAH/IMVS Research Committee (2005-2009)

Chair, RAH/IMVS Research Fellowship Sub-Committee (2005-2009)

Member, NHMRC Regional Grants Interviewing Committee (1999)

Member, Cancer Council Research Advisory Committee (1999-2001)

Member, NHMRC Grant Reviewing Panels (GRP) (2001, 2002, 2004, 2010, 2011, 2015)

Deputy Chair, NHMRC GRP (2005)

Chair, NHMRC GRP (2006, 2007)

Member, Cancer Australia Grant Review Panel (2009)

Member, NHMRC Academy (2011)

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Analysis of arrdc4 function in ubiquitination and extracellular vesicle biogenesis.	Current
Investigation of retromer in tau proteostasis	Current
Screens to identify putative regulators of autophagy-dependent cell death in Drosophila	Current
Deciphering the role of caspase-2 in protecting against genetic instability and tumour suppression	Completed
Regulation and mechanism of autophagy-dependent developmental cell death in Drosophila melanogaster larval midgut	Completed

Professor Sharad Kumar

Alternative contact

Alternative contact details

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Highlights

Chapters

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Fellowship Selection Committee

Member, National Committee for Biomedical Sciences

Fellowship Selection Committee

Member, National Committee for Biomedical Sciences

President

Scientist of the year - nomination

Affiliate Professor of Medicine

Associate Editor

Board member

Committee member, Assigners Academy

Editorial Advisory Board

Editorial Board Member

Editorial Board Member

Editorial Board Member

Fellowship Selection Committee

Finalist, South Australian Scientist of the Year Award

Member

Member

Member

Member

Member

Member

Member of the Order of Australia (AM)

Member, National Committee for Biomedical Sciences

President

SAIMA President Award

Affiliate Professor of Medicine

Associate Editor

Committee member, Assigners Academy

Editorial Advisory Board

Editorial Board Member

Editorial Board Member

Editorial Board Member

Fellowship Selection Committee

Member

Member

Member

Member

Member

Member

Member, National Committee for Biomedical Sciences

President

President-elect and council member

President-elect and council member

President's Medal

Senior Principal Research Fellowship

Fellow

Fellowship

Member, Grant Reviewing Panels

President-elect and council member

Committee member, Assigners Academy

Committee member, Assigners Academy

Lamberg Medal

Member of learned academy

Research Excellence