Centre for Cancer Biology
"I am among those who think that science has great beauty." Marie Curie
I joined UniSA in 2014 as the Chair of Cancer Biology and a Research Professor of Cell Biology.
After completing a PhD from University of Adelaide and postdoctoral training at University of Queensland, I held research scientist/staff positions at CSIRO (Geelong), RIKEN (Tsukuba, Japan), and the Cancer Institute (Tokyo, Japan), before returning to Adelaide to start a research program at the Hanson Centre for Cancer Research at IMVS (which later became SA Pathology). In 2009, with Angel Lopez, I co-founded the Centre for Cancer Biology (CCB) which I co-directed for around 11 years.
I am passionate about science and discovery research! I have been trained as a... Read more
About me
"I am among those who think that science has great beauty." Marie Curie
I joined UniSA in 2014 as the Chair of Cancer Biology and a Research Professor of Cell Biology.
After completing a PhD from University of Adelaide and postdoctoral training at University of Queensland, I held research scientist/staff positions at CSIRO (Geelong), RIKEN (Tsukuba, Japan), and the Cancer Institute (Tokyo, Japan), before returning to Adelaide to start a research program at the Hanson Centre for Cancer Research at IMVS (which later became SA Pathology). In 2009, with Angel Lopez, I co-founded the Centre for Cancer Biology (CCB) which I co-directed for around 11 years.
I am passionate about science and discovery research! I have been trained as a biochemist, molecular biologist and cell biologist. My current research interests are in molecular mechanisms of disease, including cancer biology. Our research has resulted in fundamental discoveries in two key fields of intense contemporary interest: cell death and ubiquitin-dependent protein modification. Some of our key discoveries include the Nedd genes, e.g. identification of one of the first mammalian caspases (Nedd2/caspase-2); a novel family of ubiquitin ligases (the Nedd4 family); and the ubiquitin-like protein Nedd8 that is involved in a protein-modification process, now widely known as Neddylation. We also discovered and characterised a large part of the Drosophila cell death machinery, identified Ndfip1 and Ndfip2 as adaptors/regulators of ubiquitin ligases and defined a previously unknown autophagy-dependent cell death program during development. Our work has resulted in groundbreaking contributions to the understanding of many human ailments including cancer, cardiovascular and kidney diseases.
I am a Fellow of the Australian Academy of Science (AAS) and the Australian Academy of Health and Medical Sciences (AAHMS). In 2018 I was appointed a Member of the Order of Australia (AM). My professional contributions have also been recognised through a Wellcome Trust (UK) Senior Fellowship in Medical Sciences, the ASBMB Amersham Biosciences Award, the Ranbaxy Research Award, the Lemberg Medal of the ASBMB, the FAOBMB Research Excellence Award, the ANZSCDB President's Medal and the '2020 South Australian Scientist of the Year' award.
Our research has been published over 275 articles, cited more than 50,000 times with a current H index of 99 (Google Scholar). The teams work has been presented in over 240 invited international and national talks and seminars. I have had the privilege of mentoring 30 postdoctoral scientists and 24 PhD students.
About me
Doctor of Biochemistry The University of Adelaide
Master of Science GB Pant University
Bachelor of Science Rohilkhand University
Cancer Biology
Cell Death
Ubiquitination
Disease models and mechanisms
Cellular and molecular biology
Research
Excludes commercial-in-confidence projects.
Regulation of autophagy dependent cell and tissue deletion, ARC - Discovery Projects, 01/01/2021 - 31/12/2023
Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2021
Deciphering the mechanisms of caspase-2-mediated suppression of aneuploidy and tumourigenesis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Ubiquitination-regulated sodium homeostasis in kidney disease, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer, NHMRC - Project Grant, 01/01/2018 - 30/06/2021
Cell death by self-eating: understanding autophagy-dependent tissue removal, ARC - Discovery Projects, 13/01/2017 - 12/01/2020
Hormone dependent autophagy and growth signalling in developmental cell death, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Exploring the role of Arrcd4 in extracellular vesicle biogenesis and its implications in tissue homeostasis , NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Nedd4-2: a new player in polycystic kidney disease, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Deciphering the function of capcase-2 in DNA damage response and tumour suppression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
Post-translational control of cell fate decision, ARC - Discovery Projects, 01/01/2015 - 31/12/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
Understanding the role of capcase-2 in cellular stress response and ageing, NHMRC - Project Grant, 06/03/2014 - 31/12/2016
A novel mechanism for regulating membrane proteins by ubiquitin ligases and their adaptors, NHMRC - Project Grant, 01/01/2014 - 31/12/2016
Autophagy and growth signalling in developmentally programmed cell death, NHMRC - Project Grant, 01/01/2014 - 31/12/2016
NHMRC Equip 2015 - SynergyHT fluorescence and UV/Vis 96-well plate reader for high throughput nucleic acid quantification via picogreen, NHMRC - Equipment Only Grants, 01/01/2016 - 31/12/2016
Deciphering the mechanisms of a caspase-mediated tumour suppressor pathway, Worldwide Cancer Research (formerly - Association for International Cancer Research), 01/06/2013 - 31/08/2016
NHMRC Equipment Grant 2014: Eppendorf Nexus Gradient PCR, NHMRC - Equipment Only Grants, 01/01/2015 - 31/12/2015
NHMRc Equipment Grant 2014: ChemiDoc MP system, NHMRC - Equipment Only Grants, 01/01/2015 - 31/12/2015
Physiological function of Nedd4-2 in regulating the epithelial sodium channel and cystic fibrosis transmembrane conductance regulator, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2015
Research
Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus
Open access indicates that an output is open access.
Year | Output |
---|---|
2021 |
Open access
10
10
15
|
2021 |
Open access
11
11
3
|
2019 |
Open access
245
232
19
|
2017 |
Open access
101
104
2
|
2014 |
Open access
243
687
17
|
Year | Output |
---|---|
2023 |
|
2021 |
Open access
6
|
2013 |
1
|
Year | Output |
---|---|
2022 |
Open access
2
|
2022 |
4
|
2022 |
Open access
|
2022 |
Open access
7
|
2022 |
Open access
16
|
2021 |
5
5
18
|
2021 |
10
12
18
|
2021 |
Open access
2
1
26
|
2021 |
Open access
5
7
2
|
2021 |
483
197
|
2021 |
Open access
76
68
144
|
2021 |
Open access
10
10
15
|
2021 |
Open access
10
10
5
|
2021 |
Open access
4
3
113
|
2021 |
Open access
11
11
3
|
2021 |
8
8
34
|
2021 |
1
1
2
|
2020 |
3
2
4
|
2020 |
Open access
5
6
4
|
2020 |
2
2
102
|
2020 |
Open access
2
1
2
|
2020 |
Open access
4
4
5
|
2020 |
1
1
5
|
2020 |
24
23
11
|
2019 |
98
87
7
|
2019 |
Open access
245
232
19
|
2019 |
Open access
3
5
5
|
2019 |
Open access
33
33
4
|
2019 |
Open access
2
2
5
|
2019 |
5
5
4
|
2019 |
Open access
19
16
6
|
2018 |
Open access
29
24
4
|
2018 |
Open access
83
81
14
|
2018 |
Open access
2187
1814
168
|
2018 |
Open access
9
9
3
|
2018 |
Open access
43
44
1
|
2018 |
Open access
25
26
15
|
2017 |
Open access
41
40
10
|
2017 |
Open access
101
104
2
|
2017 |
Open access
841
818
69
|
2017 |
Open access
14
13
2
|
2017 |
Open access
5
5
2
|
2017 |
10
10
|
2016 |
10
12
4
|
2016 |
Open access
18
19
10
|
2016 |
Open access
8
8
|
2016 |
Open access
220
199
11
|
2016 |
Open access
3822
3241
|
2016 |
Open access
27
27
1
|
2016 |
Open access
23
24
10
|
2016 |
Open access
11
13
1
|
2016 |
Open access
12
12
|
2015 |
Open access
90
90
|
2015 |
1
8
|
2015 |
4
1
|
2015 |
9
1
|
2015 |
Open access
10
1
|
2015 |
Open access
1
1
|
2015 |
6
1
|
2015 |
129
128
2
|
2015 |
Open access
623
613
29
|
2015 |
Open access
812
788
76
|
2015 |
Open access
90
91
1
|
2015 |
Open access
26
25
1
|
2015 |
Open access
11
16
7
|
2015 |
Open access
28
30
10
|
2015 |
Open access
16
41
13
|
2014 |
Open access
12
12
2
|
2014 |
9
9
|
2014 |
2
|
2014 |
Open access
18
18
1
|
2014 |
Open access
27
27
4
|
2014 |
Open access
42
40
1
|
2014 |
Open access
243
687
17
|
2014 |
Open access
21
21
1
|
2013 |
Open access
49
49
1
|
2013 |
Open access
41
39
1
|
2013 |
Open access
151
138
3
|
2013 |
Open access
68
68
1
|
2013 |
Open access
51
51
16
|
2013 |
Open access
100
105
24
|
2013 |
Open access
187
179
6
|
2013 |
Open access
20
23
4
|
2012 |
Open access
53
51
|
2012 |
Open access
304
293
|
2012 |
Open access
76
77
|
2012 |
Open access
1832
1720
22
|
2012 |
Open access
32
28
|
2012 |
Open access
83
80
1
|
2012 |
Open access
2727
3500
61
|
2012 |
Open access
28
26
1
|
2012 |
Open access
56
53
|
2011 |
Open access
71
67
|
2011 |
Open access
15
15
|
2011 |
Open access
31
31
|
2011 |
Open access
10
10
|
2011 |
Open access
65
60
|
2010 |
Open access
49
48
|
2010 |
Open access
46
40
|
2010 |
Open access
17
19
|
2010 |
Open access
13
13
|
2010 |
Open access
32
31
|
2010 |
Open access
161
160
|
2009 |
Open access
283
277
|
2009 |
Open access
|
2009 |
Open access
129
126
|
2009 |
Open access
80
79
|
2009 |
Open access
76
72
|
2009 |
Open access
2148
2319
|
2009 |
14
11
|
2009 |
115
115
|
2009 |
Open access
43
40
|
2009 |
Open access
742
719
|
2008 |
Open access
23
23
|
2008 |
Open access
126
119
|
2008 |
28
27
|
2008 |
Open access
47
43
|
2008 |
Open access
108
103
|
2008 |
Open access
27
28
|
2008 |
Open access
156
142
|
2008 |
Open access
102
97
|
2008 |
13
14
|
2008 |
Open access
111
109
|
2008 |
23
22
|
Research
Cancer Biology
Cell Death
Ubiquitination
Disease models and mechanisms
Cellular and molecular biology
PROFESSIONAL RECOGNITION
Fellowships of the Learned Academies
Fellow of the Australian Academy of Science (FAA)
Fellow of the Australian Academy of Health and Medical Sciences (FAHMS)
International and National Fellowships held
NHMRC Level 3 Investigator (Senior Principal Research Fellowship)
NHMRC Senior Principal Research Fellowship
NHMRC Principal Research Fellowship
Wellcome Trust (UK) Senior Fellowship in Medical Science
Florey Research Fellowship
Japanese Science and Technology Agency (STA) Fellowship
University of Queensland Postdoctoral Fellowship
Significant Awards and Prizes
South Australian Scientist of Year
Member of the Order of Australia
ANZSCDB President's Medal
FAOBMB Award for Research Excellence
ASBMB Lemberg Medal
Ranbaxy Science Foundation Award in Basic Medical Sciences
External engagement & recognition
Organisation | Country |
---|---|
Ain Shams University | EGYPT |
Australian National University | AUSTRALIA |
Baker Heart and Diabetes Institute | AUSTRALIA |
Baylor College of Medicine | UNITED STATES |
Boston University | UNITED STATES |
Centre de Recherche des Cordeliers | FRANCE |
Centro de Investigaciones Biológicas | SPAIN |
Childrens Cancer Institute Australia for Medical Research | AUSTRALIA |
Cold Spring Harbor Laboratory | UNITED STATES |
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation) | AUSTRALIA |
Deakin University | AUSTRALIA |
Emory University | UNITED STATES |
Federal University of Sao Carlos | BRAZIL |
Federico II University | ITALY |
Flinders Medical Centre | AUSTRALIA |
Florey Neuroscience Institute | AUSTRALIA |
Garvan Institute of Medical Research | AUSTRALIA |
Genentech | UNITED STATES |
Georgetown University | UNITED STATES |
Ghent University | BELGIUM |
Griffith University | AUSTRALIA |
Hanson Institute | AUSTRALIA |
Harry Perkins Institute of Medical Research | AUSTRALIA |
Hebrew University | MEXICO |
Hong Kong Baptist University | HONG KONG |
Hudson Institute of Medical Research | AUSTRALIA |
Icahn School of Medicine at Mount Sinai | UNITED STATES |
Indian Council of Medical Research | INDIA |
Institute of Medical and Veterinary Science | AUSTRALIA |
Jilin University | CHINA |
Johannes Gutenberg University of Mainz | GERMANY |
Kanazawa University | JAPAN |
Kanazawa University Hospital | JAPAN |
Karolinska Institute | SWEDEN |
Keio University | JAPAN |
La Trobe University | AUSTRALIA |
Lausanne University Hospital | FRANCE |
Max Planck Institute of Experimental Medicine | GERMANY |
Medical University of Graz | AUSTRIA |
Medical University of Innsbruck | AUSTRIA |
Monash University | AUSTRALIA |
National Institute on Aging | UNITED STATES |
New York University | UNITED STATES |
Okayama University | JAPAN |
Osaka University | JAPAN |
Ozgene | AUSTRALIA |
Pavlov University | RUSSIAN FEDERATION |
Pfizer Worldwide Research and Development | UNITED STATES |
Pierre and Marie Curie University | FRANCE |
Queensland Institute of Medical Research | AUSTRALIA |
Queensland University of Technology | AUSTRALIA |
Regina Elena National Cancer Institute | ITALY |
Ritsumeikan University | JAPAN |
RMIT University | AUSTRALIA |
Royal Adelaide Hospital | AUSTRALIA |
SA Pathology | AUSTRALIA |
SA Water Corporation | AUSTRALIA |
Sapienza University of Rome | ITALY |
South Australian Health and Medical Research Institute (SAHMRI) | AUSTRALIA |
St. Jude Children's Research Hospital | UNITED STATES |
Stanford University | UNITED STATES |
State University of New York Buffalo | UNITED STATES |
Technion Israel Institute of Technology | ISRAEL |
The Hospital for Sick Children | CANADA |
The Institut Pasteur (AKA L'Institut Pasteur) | FRANCE |
Thomas Jefferson University | UNITED STATES |
Tokyo Medical Dental University | JAPAN |
Tokyo Medical University | JAPAN |
University of Adelaide | AUSTRALIA |
University Of Angers | FRANCE |
University of Cambridge | UNITED KINGDOM |
University of Cologne | GERMANY |
University of Geneva | SWITZERLAND |
University of Iowa | UNITED STATES |
University of Konstanz | GERMANY |
University of Lausanne | SWITZERLAND |
University of London | UNITED KINGDOM |
University of Massachusetts Amherst | UNITED STATES |
University of Massachusetts Medical School | UNITED STATES |
University of Melbourne | AUSTRALIA |
University of Michigan | UNITED STATES |
University of Michigan-Ann Arbor | UNITED STATES |
University of Minnesota, Twin Cities | UNITED STATES |
University of New South Wales | AUSTRALIA |
University of Newcastle | AUSTRALIA |
University of Otago | NEW ZEALAND |
University Of Paris Sud (Paris 11) | FRANCE |
University of Pennsylvania | UNITED STATES |
University of Pittsburgh | UNITED STATES |
University of Queensland | AUSTRALIA |
University of Rome Tor Vergata | ITALY |
University of South Australia | AUSTRALIA |
University of Sydney | AUSTRALIA |
University of Texas Southwestern Medical Center | UNITED STATES |
University of Western Australia | AUSTRALIA |
University of Zurich | SWITZERLAND |
Walter and Eliza Hall Institute of Medical Research | AUSTRALIA |
Weill Cornell Medical College | UNITED STATES |
Weill Cornell Medicine | UNITED STATES |
External engagement & recognition
Engagement/recognition | Year |
---|---|
South Australian Scientist of the Year, 2020SA Science Excellence and Innovation Awards |
2021 |
Fellowship Selection CommitteeAustralian Academy of Science |
2020 |
Member, National Committee for Biomedical SciencesAustralian Academy of Science |
2020 |
Fellowship Selection CommitteeAustralian Academy of Science |
2019 |
Member, National Committee for Biomedical SciencesAustralian Academy of Science |
2019 |
PresidentAustralia and New Zealand Society for Cell and Developmental Biology |
2019 |
Scientist of the year - nominationSA Science Excellence Awards |
2019 |
Affiliate Professor of MedicineThe University of Adelaide |
2018 |
Associate EditorMolecular and Cellular Oncology |
2018 |
Board MemberInternational Cell Death Society |
2018 |
Committee member, Assigners AcademyNational Health and Medical Research Council (NHMRC) |
2018 |
Editorial Advisory BoardOncotarget |
2018 |
Editorial Board MemberCell Death and Differentiation |
2018 |
Editorial Board MemberScienceOPEN |
2018 |
Editorial Board MemberFrontiers in Cancer Molecular Targets and Therapeutics |
2018 |
Fellowship Selection CommitteeAustralian Academy of Science |
2018 |
Finalist, South Australian Scientist of the Year AwardGovernment of South Australia |
2018 |
MemberAmerican Society for Biochemistry and Molecular Biology |
2018 |
MemberAustralian Society for Biochemistry and Molecular Biology (ASBMB) |
2018 |
MemberEuropean Cell Death Organization |
2018 |
MemberJapan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA) |
2018 |
MemberFaculty of 1000 |
2018 |
MemberResearch Strategy Group of the Beat Cancer Project |
2018 |
Member of the Order of Australia (AM)Order of Australia |
2018 |
Member, National Committee for Biomedical SciencesAustralian Academy of Science |
2018 |
PresidentAustralia and New Zealand Society for Cell and Developmental Biology |
2018 |
SAIMA President AwardSouth Australian Indian Medical Association (SAIMA) |
2018 |
Affiliate Professor of MedicineThe University of Adelaide |
2017 |
Associate EditorMolecular and Cellular Oncology |
2017 |
Committee member, Assigners AcademyNational Health and Medical Research Council (NHMRC) |
2017 |
Editorial Advisory BoardOncotarget |
2017 |
Editorial Board MemberCell Death and Differentiation |
2017 |
Editorial Board MemberScienceOPEN |
2017 |
Editorial Board MemberFrontiers in Cancer Molecular Targets and Therapeutics |
2017 |
Fellowship Selection CommitteeAustralian Academy of Science |
2017 |
MemberAmerican Society for Biochemistry and Molecular Biology |
2017 |
MemberAustralian Society for Biochemistry and Molecular Biology (ASBMB) |
2017 |
MemberEuropean Cell Death Organization |
2017 |
MemberJapan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA) |
2017 |
MemberFaculty of 1000 |
2017 |
MemberResearch Strategy Group of the Beat Cancer Project |
2017 |
Member, National Committee for Biomedical SciencesAustralian Academy of Science |
2017 |
PresidentAustralia and New Zealand Society for Cell and Developmental Biology |
2017 |
President-elect and council memberAustralia and New Zealand Society for Cell and Developmental Biology |
2017 |
President-elect and council memberAustralia and New Zealand Society for Cell and Developmental Biology |
2016 |
President's MedalAustralia and New Zealand Society for Cell and Developmental Biology |
2016 |
Senior Principal Research FellowshipNational Health and Medical Research Council (NHMRC) |
2016 |
FellowAustralian Academy of Health and Medical Science |
2015 |
FellowshipAustralia and New Zealand Society for Cell and Developmental Biology |
2015 |
Member, Grant Reviewing PanelsNational Health and Medical Research Council (NHMRC) |
2015 |
President-elect and council memberAustralia and New Zealand Society for Cell and Developmental Biology |
2015 |
Committee member, Assigners AcademyNational Health and Medical Research Council (NHMRC) |
2014 |
Committee member, Assigners AcademyNational Health and Medical Research Council (NHMRC) |
2013 |
FellowAustralian Academy of Science |
2013 |
Lamberg MedalAustralian Society for Biochemistry and Molecular Biology (ASBMB) |
2013 |
Member of learned academyAustralian Academy of Science |
2013 |
Research ExcellenceFederation of Asian and Oceanian Biochemists and Molecular Biologists |
2013 |
Committee member, Assigners AcademyNational Health and Medical Research Council (NHMRC) |
2012 |
Editorial Boards, Advisory Committees, Professional Societies and Peer Review Panels
Member, Program Committee for 26th Congress of IUBMB (2022-2024)
Member, Award Selection Panel, Australasian Society of Cell Death (2020, 2021, 2022)
Member, Australian Academy of Science National Committee for Biomedical Sciences (2017- current)
Member, Beat Cancer Project Research Strategy Group, Cancer Council SA (2017- current)
Member of the Board, International Society of Cell Death (2018- current)
Member, Steering Committee of Research Centre for Extracellular Vesicles (RCEV) (2021- current)
Member, Selection Panel, SA Science Excellence and Innovation Awards (2021, 2022)
ACDS Pioneer and Advisor, Australasian Cell Death Society (2020- current)
Member, International Society of Extracellular Vesicles (2020- current)
Member, American Society for Biochemistry and Cell Biology (ASBMB) (1997- current)
Member, Australian Society for Biochemistry and Cell Biology (ASBMB) (1996- current)
Member, American Association for Advancement of Science (AAAS) (1995- current)
Member, Ausbiotech (2019- current)
Member, National Association of Research Fellows (NARF) (Since 2000)
Member, Editorial Board, Cell Death & Differentiation (1996- current)
Member, Faculty of 1000 (2001- current)
Member, ANZSCDB Committee (2019- current)
Executive and Past-President, ANZSCDB (2019-2021)
President, Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB) (2017-2019)
Member, AAS Sectional Committee SC8 (2017-2020)
Member, NHMRC Investigator Grants Panel (2019, 2022)
Member, NHMRC Assigners Academy (2012, 2013, 2014, 2017, 2018)
Member, NHMRC Grant Reviewing Panels (GRP) (2001, 2002, 2004, 2010, 2011, 2015)
Member, NHMRC Academy (2011)
Member, Cancer Australia Grant Review Panel (2009)
Member, RAH/IMVS Research Committee (2005-2009)
Chair, RAH/IMVS Research Fellowship Sub-Committee (2005-2009)
Chair, NHMRC GRP (2006, 2007)
Deputy Chair, NHMRC GRP (2005)
Member, Cancer Council Research Advisory Committee (1999-2001)
Member, NHMRC Regional Grants Interviewing Committee (1999)
Teaching & student supervision
Supervisions from 2010 shown
Thesis title | Student status |
---|---|
High fat diets and breast cancer | Current |
Investigating the functions of the ubiquitin ligase NEDD4-2 in kidney disease. | Current |
Modulation of NEDD4-2 expression and activity as a cellular mechanism for ameliorating kidney disease | Current |
Regulation of autophagy in cell and tissue homeostasis | Current |
Analysis of Arrdc4 ubiquitination and its function in extracellular vesicles biogenesis | Completed |
Deciphering the role of caspase-2 in protecting against genetic instability and tumour suppression | Completed |
Identifying regulators of autophagy-dependent cell death | Completed |
Regulation and mechanism of autophagy-dependent developmental cell death in Drosophila melanogaster larval midgut | Completed |
Regulation of retromer and its role in tauopathies | Completed |