Professor Sharad Kumar

Bradley Distinguished Professor Centre for Cancer Biology

City West Campus (HB11-13)
tel +61 8 830 27918

email Sharad.Kumar@unisa.edu.au

Alternative contact

Research Degree Supervisor

About me

I joined the University of South Australia (UniSA) in 2014 as Chair of Cancer Biology and Research Professor of Cell Biology.

After earning my PhD from the University of Adelaide and completing postdoctoral training at the University of Queensland, I held Research Scientist positions at CSIRO (Geelong), RIKEN (Tsukuba, Japan) and the Cancer Institute (Tokyo, Japan). I later returned to Adelaide to establish a research program at the Hanson Centre for Cancer Research at IMVS (which eventually became SA Pathology). In 2009, together with Angel Lopez, I co-founded the Centre for Cancer Biology (CCB), which I co-directed for approximately 11 years.

My research has been continuously supported by national and international fellowships for over ... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

About me

I joined the University of South Australia (UniSA) in 2014 as Chair of Cancer Biology and Research Professor of Cell Biology.

My research has been continuously supported by national and international fellowships for over three decades. Trained as a biochemist, molecular biologist, and cell biologist, I am deeply passionate about science and discovery. My current research focuses on the molecular mechanisms of disease, particularly cancer. Our work has led to foundational discoveries in two major areas of contemporary biomedical sciences: 'Cell Death' and 'Ubiquitin-dependent protein modification'. Some key contributions include:

Identification of the Nedd genes, including one of the first mammalian caspases (Nedd2/caspase-2)

Discovery of the Nedd4 family of ubiquitin ligases

Discovery of Nedd8, a ubiquitin-like protein central to the now widely recognised process of Neddylation

Elucidation of the Drosophila cell death machinery, including the discovery of 4 of 7 caspases and both Bcl-2-like proteins

Identification of Ndfip1 and Ndfip2 as adaptors/regulators of ubiquitin ligases

Discovery of a novel autophagy-dependent cell death program during development

These findings have advanced our understanding of various human diseases, including cancer, cardiovascular conditions, and kidney disorders. Our research has been published in approximately 300 articles, cited over 68,000 times, with a current H-index of 105 (Google Scholar). I have delivered more than 250 invited talks and seminars at national and international forums. Over the course of my career, I’ve had the privilege of mentoring 30 postdoctoral scientists, 32 laboratory staff, and 25 PhD students.

Research

Research focus

Biochemistry and Cell Biology
Biological Sciences
Medical and Health Sciences
Clinical Sciences
Oncology and Carcinogenesis

Highlights

Cancer biology

Cell death modalities

Ubiquitination

Disease models and mechanisms

Cellular and molecular biology

Extracellular Vesicles (EVs)

Research

Projects

Excludes commercial-in-confidence projects.

New mechanisms regulating the biogenesis of extracellular vesicles, ARC - Discovery Projects, 01/01/2024 - 31/12/2026
Regulation of autophagy dependent cell and tissue deletion, ARC - Discovery Projects, 01/01/2021 - 31/03/2024
Deciphering the mechanisms of caspase-2-mediated suppression of aneuploidy and tumourigenesis, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Regulation of cell death, cell survival and ubiquitination in normal physiology and disease, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2021
Ubiquitination-regulated sodium homeostasis in kidney disease, NHMRC - Project Grant, 01/01/2019 - 31/12/2021
Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer, NHMRC - Project Grant, 01/01/2018 - 30/06/2021
Cell death by self-eating: understanding autophagy-dependent tissue removal, ARC - Discovery Projects, 13/01/2017 - 12/01/2020
Exploring the role of Arrcd4 in extracellular vesicle biogenesis and its implications in tissue homeostasis , NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Hormone dependent autophagy and growth signalling in developmental cell death, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Nedd4-2: a new player in polycystic kidney disease, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Deciphering the function of capcase-2 in DNA damage response and tumour suppression, NHMRC - Project Grant, 01/01/2014 - 31/12/2017
Post-translational control of cell fate decision, ARC - Discovery Projects, 01/01/2015 - 31/12/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2023	Puccini, J & Kumar, S 2023, 'The Caspase family of proteases', in Ralph A. Bradshaw, Gerald W. Hart & Philip D. Stahl (eds.), Encyclopedia of Cell Biology, 2nd, Academic Press, UK, vol. 5, pp. 165-177. 2
2021	Foot, NJ & Kumar, S 2021, 'The role of extracellular vesicles in sperm function and male fertility', in S Mathivananm et al. (eds), New Frontiers: Extracellular Vesicles, Springer, Switzerland, ch. 19. pp. 483-500. Open access 25
2013	Dorstyn, L & Kumar, S 2013, 'Insect caspases', in Alan Barrett, Neil Rawlings & J Woessner (eds), Handbook of proteolytic enzymes, 3, Elsevier, UK, vol. 2, ch. 514, pp. 2286-2295. 1

Journal Articles

Year	Output
2025	Manning, JA, Jesudason, S, Moretti, PA, Pitson, SM, Chou, AS, Shabbar, M, Saad, S, Pollock, C & Kumar, S 2025, 'Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice', vol. 16, no.496 , pp. 1-13. Open access
2025	Shabbar, M, Manning, J, Lim, Y, Shah, S, Sinha, D, Nikolic, A, Sandow, JJ & Kumar, S 2025, 'Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination', Cell Death Discovery, vol. 11, no. 1, article no. 393, pp. 1-11. Open access
2025	Shah, MV, Hung, K, Baranwal, A, Kutyna, MM, Brown, A, Kumar, S, Scott, H, Hahn, C & Hiwase, D and 28 other authors 2025, 'Evidence-based risk stratification of myeloid neoplasms harboring TP53 mutations.', Blood Advances, online, pp. 1-28.
2025	Shah, MV, Hung, K, Baranwal, A, Wechalekar, G, Brown, A, Kumar, S, Scott, HS, Hahn, CN & Hiwase, D and 28 other authors 2025, 'Validation of the 5th edition of the World Health Organization and International Consensus Classification guidelines for TP53-mutated myeloid neoplasm in an independent international cohort', Blood Cancer Journal, vol. 15, no. 1, article no. 88 , pp. 1-11. Open access 2 1
2025	Shah, S, Manning, J, Lim, Y, Sinha, D, Murthy, AMV, Ganesan, R, Robinson, N, Alnemri, ES, Masters, SL, Vince, JE & Kumar, S 2025, 'NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury', Cell Death and Differentiation, online, pp. 1-18. Open access
2025	Umargamwala, R, Nicolson, S, Manning, J, Carosi, JM, Kumar, S & Denton, D 2025, 'Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster', vol. 11, article no. 181, pp. 1-13. Open access 1 1
2025	Windley, SP, Neirijnck, Y, Vidovic, D, Schwarz, Q, Kumar, S, Nef, S & Wilhelm, D 2025, 'NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis', Endocrinology, in press. Open access
2024	Carosi, JM, Hein, LK, Sandow, JJ, Dang, LVP, Hattersley, K, Denton, D, Kumar, S & Sargeant, TJ 2024, 'Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling', Autophagy, vol. 20, no. 4, pp. 863-882. 6 6 8
2024	Dawar, S, Benitez, MC, Lim, Y, Dite, TA, Yousef, JM, Thio , N, Garciaz, S, Jackson, TD, Milne, J V, Dagley, LF, Phillips, WA, Kumar, S & Clemons, NJ 2024, 'Caspase-2 protects against ferroptotic cell death', Cell Death and Disease, vol. 15, no. 3, article no. 182, pp. 1-12. Open access 11 11
2024	Nicolson, S, Manning, JA, Lim, Y, Jiang, X, Kolze, E, Dayan, S, Umargamwala, R, Xu, T, Sandow, JJ, Webb, AI, Webb, A I, Kumar, S & Denton, D 2024, 'The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy', Communications Biology, vol. 7, no. 1, pp. 1-24. Open access 5 3 7
2024	Umargamwala, R, Manning, J, Dorstyn, L, Denton, D & Kumar, S 2024, 'Understanding developmental cell death using Drosophila as a model system', Cells, vol. 13, no. 4, article no. 347, pp. 1-16. Open access 3 2 3
2024	Vora, S, Andrew, A, Kumar, RP, Nazareth, D, Bonfim-Melo, A, Lim, Y, Ong, XY, Fernando, M, He, Y, Hooper, JD, McMillan, NA, Urosevic, J, Travers, J, Saeh, J, Kumar, S, Jones, MJ & Gabrielli, B 2024, 'Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition', Cell Death and Disease, vol. 15, no. 11, article no. 810, pp. 1-9. Open access 5 5 1
2024	Welsh, JA, Goberdhan, DC, O'Driscoll, L, Buzas, E I, Witwer, KW & Kumar, S and 66 other authors. UniSA internal author is part of the consortia 2024, 'Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches', Journal of Extracellular Vesicles, vol. 13, no. 2, article no. e12404, pp. 1-84. Open access 1975 1608 166
2023	Anand, S, Nedeva, C, Chitti, S V, Fonseka, P, Kang, T, Gangoda, L, Tabassum, N I, Abdirahman, S, Arumugam, T V, Putoczki, TL, Kumar, S & Mathivanan, S 2023, 'The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling', Cell Death and Disease, vol. 14, article no. 828 , pp. 1-11. Open access 9 9 9
2023	Carosi, JM, Denton, D, Kumar, S & Sargeant, TJ 2023, 'Receptor recycling by retromer', Molecular and Cellular Biology, vol. 43, no. 7, pp. 317-334. Open access 15 16 3
2023	Dagdeviren, S, Hoang, MF, Sarikhani, M, Meier, V, Benoit, JC, Okawa, MC, Melnik, VY, Ricci-Blair, EM, Foot, N, Friedline, RH, Hu, X, Tauer, LA, Srinivasan, A, Prigozhin, MB, Shenoy, SK, Kumar, S, Kim, JK & Lee, RT 2023, 'An insulin-regulated arrestin domain protein controls hepatic glucagon action', Journal of Biological Chemistry, vol. 299, no. 8, article no. 105045, pp. 1-16. Open access 7 8 10
2023	Hiwase, D, Hahn, C, Tran, ENH, Chhetri, R, Wang, P, Kumar, S, Brown, A, Scott, H, Kok, CH & Shah, MV and 41 other authors 2023, 'TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype', Blood, vol. 141, no. 9, pp. 1087-1091. Open access 28 24 1
2023	Shah, MV, Tran, ENH, Shah, S, Chhetri, R, Brown, AL, Scott, HS, Kumar, S, Hahn, CN, Kok, CH & Hiwase, DK and 12 other authors 2023, 'TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms', Blood Cancer Journal, vol. 13, no. 1, article no. 51, pp. 1-9. Open access 32 32 1
2023	Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, SA, Kumar, S & Galluzzi, L 2023, 'Apoptotic cell death in disease-Current understanding of the NCCD 2023', Cell Death and Differentiation, vol. 30, pp. 1097-1154. 259 237 94
2022	Farooq, AU, Gembus, K, Sandow, JJ, Webb, A, Mathivanan, S, Manning, JA, Shah, SS, Foot, NJ & Kumar, S 2022, 'K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis', Journal of Extracellular Vesicles, vol. 11, no. 2, article no. e12188, pp. 1-15. Open access 14 13 2
2022	Kumar, S, Dorstyn, L & Lim, Y 2022, 'The role of caspases as executioners of apoptosis', Biochemical Society Transactions, vol. 50, no. 1, pp. 33-45. Open access 45 41 4
2022	Kutyna, MM, Kok, CH, Lim, Y, Tran, ENH, Campbell, D, Paton, S, Thompson-Peach, C, Lim, K, Cakouros, D, Arthur, A, Hughes, T, Kumar, S, Thomas, D, Gronthos, S & Hiwase, DK 2022, 'A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure', Leukemia, vol. 36, no. 11, pp. 2678-2689. Open access 17 17 5
2022	Lohraseb, I, McCarthy, P, Secker, G, Marchant, C, Wu, J, Ali, N, Kumar, S, Daly, RJ, Harvey, NL, Kawabe, H, Kleifeld, O, Wiszniak, S & Schwarz, Q 2022, 'Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells', Nature Communications, vol. 13, no. 1, pp. 1-18. Open access 5 6 7
2022	Windley, SP, Mayère, C, McGovern, AE, Harvey, NL, Nef, S, Schwarz, Q, Kumar, S & Wilhelm, D 2022, 'Loss of NEDD4 causes complete XY gonadal sex reversal in mice', Cell Death and Disease, vol. 13, article no. 75, pp. 1-10. Open access 5 5 10
2021	Carosi, JM, Denton, D, Kumar, S & Sargeant, TJ 2021, 'Retromer dysfunction at the nexus of tauopathies', Cell Death and Differentiation, vol. 28, no. 3, pp. 884-899. 15 13 18
2021	Carosi, JM, Hein, LK, van den Hurk, M, Adams, R, Milky, B, Singh, S, Bardy, C, Denton, D, Kumar, S & Sargeant, TJ 2021, 'Retromer regulates the lysosomal clearance of MAPT/tau', Autophagy, vol. 17, no. 9, pp. 2217-2237. Open access 30 34 16
2021	Carosi, JM, Nguyen, TN, Lazarou, M, Kumar, S & Sargeant, TJ 2021, 'ATG8ylation of proteins: a way to cope with cell stress?', The Journal of Cell Biology, vol. 220, no. 11, pp. 1-4. Open access 15 14 22
2021	Foot, NJ, Gonzalez, MB, Gembus, K, Fonseka, P, Sandow, JJ, Nguyen, TT, Tran, D, Webb, AI, Mathivanan, S, Robker, RL & Kumar, S 2021, 'Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation', Journal of Extracellular Vesicles, vol. 10, no. 8, article no. e12113, pp. 1-21. Open access 21 22 27
2021	Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Kumar, S & Tong, C and 2923 other authors 2021, 'Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)', Autophagy, vol. 17, no. 1, pp. 1-382. Open access 2007 1895 191
2021	Klionsky, DJ, Petroni, G, Amaravadi, RK, Baehrecke, EH, Kumar, S & Pietrocola, F and 53 other authors 2021, 'Autophagy in major human diseases', The EMBO Journal, vol. 40, no 19, article no. e108863, pp. 1-63. Open access 1206 1125 179
2021	Lim, Y, De Bellis, D, Sandow, JJ, Capalbo, L, D'Avino, PP, Murphy, JM, Webb, A I, Dorstyn, L & Kumar, S 2021, 'Phosphorylation by Aurora B kinase regulates caspase-2 activity and function', Cell Death and Differentiation, vol. 28, pp. 349-366. Open access 25 24 13
2021	Lim, Y, Dorstyn, L & Kumar, S 2021, 'The p53-caspase-2 axis in the cell cycle and DNA damage response', Experimental and Molecular Medicine, vol. 53, no. 4, pp. 517-527. Open access 41 37 4
2021	Manning, JA, Shah, SS, Nikolic, A, Henshall, TL, Khew-Goodall, Y & Kumar, S 2021, 'The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease', Cell Death and Disease, vol. 12, no. 4, article no. 398, pp. 1-16. Open access 19 18 112
2021	Shah, SS & Kumar, S 2021, 'Adaptors as the regulators of HECT ubiquitin ligases', Cell Death and Differentiation, vol. 28, no. 2, pp. 455-472. Open access 28 29 3
2021	Sheng, J, Kohno, S, Okada, N, Okahashi, N, Teranishi, K, Matsuda, F, Shimizu, H, Linn, P, Nagatani, N, Yamamura, M, Harada, K, Horike, S-i, Inoue, H, Yano, S, Kumar, S, Kitajima, S, Ajioka, I & Takahashi, C 2021, 'Treatment of retinoblastoma 1-intact hepatocellular carcinoma with cyclin-dependent kinase 4/6 inhibitor combination therapy', Hepatology, vol. 74, no. 4, pp. 1971-1993. 33 32 34
2021	Xu, T, Nicolson, S, Sandow, JJ, Dayan, S, Jiang, X, Manning, JA, Webb, A I, Kumar, S & Denton, D 2021, 'Cp1/cathepsin L is required for autolysosomal clearance in Drosophila', Autophagy, vol. 17, no. 10, pp. 2734-2749. Open access 12 13 2
2020	Denton, D, O'Keefe, L & Kumar, S 2020, 'Drosophila as a model to understand autophagy deregulation in human disorders', Progress in Molecular Biology and Translational Science, vol. 172, pp. 375-409. 7 7 4
2020	Hos, NJ, Fischer, J, Hos, D, Hejazi, Z, Calabrese, C, Ganesan, R, Murthy, AM, Rybniker, J, Kumar, S, Krönke, M & Robinson, N 2020, 'TRIM21 Is targeted for chaperone-mediated autophagy during salmonella typhimurium infection', Journal of Immunology, vol. 205, no. 9, pp. 2456-2467. Open access 26 24 5
2020	Kohno, S, Linn, P, Nagatani, N, Watanabe, Y, Kumar, S, Soga, T & Takahashi, C 2020, 'Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion', Oncogene, vol. 39, no. 34, pp. 5690-5707. Open access 12 13 98
2020	Kulathunga, N, Kohno, S, Linn, P, Nishimoto, Y, Horike, Si, Zaraiskii, MI, Kumar, S, Muranaka, H & Takahashi, C 2020, 'Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium', Cancer Science, 111, no. 7, pp. 2336-2348. Open access 4 4 2
2020	Manning, JA, Shah, SS, Henshall, TL, Nikolic, A, Finnie, J & Kumar, S 2020, 'Dietary sodium modulates nephropathy in Nedd4-2-deficient mice', Cell Death and Differentiation, vol. 27, pp. 1832-11843. Open access 11 10 6
2020	Manning, JA, Windley, SP, Sandow, JJ, Shah, SS, Western, P, Wilhelm, D & Kumar, S 2020, 'Identification of novel interacting partners of the NEDD4 ubiquitin ligase in mouse testis', Journal of Proteomics, vol. 223, article no. 103830, pp. 1-8. 3 3 4
2020	Murthy, AM, Robinson, N & Kumar, S 2020, 'Crosstalk between cGAS-STING signaling and cell death', Cell Death and Differentiation, vol. 27, no. 11, pp. 2989-3003. Open access 134 127 12
2019	Anand, S, Samuel, M, Kumar, S & Mathivanan, S 2019, 'Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles', BBA: Proteins and Proteomics, vol. 1867, article no. 140203, pp. 1-10. 233 214 6
2019	Denton, D & Kumar, S 2019, 'Autophagy-dependent cell death', Cell Death and Differentiation, vol. 26, pp. 605-616. Open access 646 617 27
2019	Denton, D, Xu, T, Dayan, S, Nicolson, S & Kumar, S 2019, 'Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation', Cell Death and Disease, vol. 10, no. 2, article no. 111, pp. 1-8. Open access 5 5 5
2019	Denton, D, Xu, T, Dayan, S, Nicolson, S & Kumar, S 2019, 'Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production', Cell Death and Differentiation, vol. 26, pp. 763-778. Open access 48 47 5
2019	Dorstyn, L, Hackett-Jones, E, Nikolic, A, Norris, MD, Lim, Y, Toubia, J, Haber, M & Kumar, S 2019, 'Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling', Cell Death and Disease, vol. 10, no. 2, pp. 1-16. Open access 7 6 6
2019	Xu, T, Denton, D & Kumar, S 2019, 'Hedgehog and Wingless signaling are not essential for autophagy-dependent cell death', Biochemical Pharmacology, vol. 162 , S1, pp. 3-13. 6 6 4
2019	Xu, T, Jiang, X, Denton, D & Kumar, S 2019, 'Ecdysone controlled cell and tissue deletion', Cell Death and Differentiation, vol. 27, no. 1, pp. 1-14. Open access 46 43 5
2018	Anand, S, Foot, N, Ang, C-S, Gembus, KM, Keerthikumar, S, Adda, CG, Mathivanan, S & Kumar, S 2018, 'Arrestin‐domain containing protein 1 (Arrdc1) regulates the protein cargo and release of extracellular vesicles', Proteomics, vol. 18, no. 17, article no. 1800266, pp. 1-16. Open access 56 49 4
2018	Dorstyn, L, Akey, CW & Kumar, S 2018, 'New insights into apoptosome structure and function', Cell Death and Differentiation, vol. 25, pp. 1194-1208. Open access 178 167 13
2018	Galluzzi, L, Vitale, I, Aaronson, S, Abrams, J, Kumar, S & Kroemer, G and 163 other authors 2018, 'Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018', Cell Death and Differentiation, vol. 25, no. 3, pp. 486-541. Open access 5321 4835 255
2018	Lim, Y, De Bellis, D, Dorstyn, L & Kumar, S 2018, 'p53 accumulation following cytokinesis failure in the absence of caspase-2', Cell Death and Differentiation, vol. 25, no. 11, pp. 2050-2052. Open access 11 10 3
2018	Manning, JA & Kumar, S 2018, 'Physiological functions of Nedd4-2: lessons from knockout mouse models', Trends in Biochemical Sciences, vol. 43, no. 8, pp. 635-647. Open access 57 60 1
2018	Wilson, CH & Kumar, S 2018, 'Caspases in metabolic disease and their therapeutic potential', Cell Death and Differentiation, vol. 25, no. 6, pp. 1010-1024. Open access 70 69 19
2017	Dawar, S, Lim, Y, Puccini, J, White, M, Thomas, P, Bouchier-Hayes, L, Green, D, Dorstyn, L & Kumar, S 2017, 'Caspase-2-mediated cell death is required for deleting aneuploid cells', Oncogene, vol. 36, no. 19, pp. 2704-2714. Open access 55 52 10
2017	Foot, NJ, Henshall, T & Kumar, S 2017, 'Ubiquitination and the regulation of membrane proteins', Physiological Reviews, vol. 97, no. 1, pp. 253-281. Open access 202 203 5
2017	Galluzzi, L, Baehrecke, EH, Ballabio, A, Boya, P, Kumar, S & Kroemer, G 2017, 'Molecular definitions of autophagy and related processes', The EMBO Journal, vol. 36, no. 13, pp. 1811-1836. Open access 1402 1306 66
2017	Henshall, TL, Manning, JA, Alfassy, OS, Goel, P, Boase, N, Kawabe, H & Kumar, S 2017, 'Deletion of Nedd4-2 results in progressive kidney disease in mice', Cell Death and Differentiation, vol. 24, pp. 2150-2160. Open access 30 31 2
2017	Wilson, CH, Nikolic, A, Kentish, SJ, Keller, M, Hatzinikolas, G, Dorstyn, L, Page, AJ & Kumar, S 2017, 'Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity', Cell Death and Disease, vol. 8, article no. e3136, pp. 1-12. Open access 14 14 2
2017	Xu, T, Kumar, S & Denton, D 2017, 'Characterization of autophagic responses in drosophila melanogaster', Methods in Enzymology, vol. 588, pp. 445-465. 11 11
2016	Camera, D, Coleman, HA, Parkington, HC, Jenkins, TA, Pow, D V, Boase, NA, Kumar, S & Poronnik, P 2016, 'Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice', Behavioural Brain Research, vol. 303, pp. 176-181. 15 15 5
2016	Dawar, S, Shahrin, NH, Sladojevic, N, D'Andrea, R, Dorstyn, L, Hiwase, DK & Kumar, S 2016, 'Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice', Cell Death and Disease, vol. 7, no. e2509, pp.1-9. Open access 25 26 10
2016	Foot, NJ, Gembus, KM, Mackenzie, K & Kumar, S 2016, 'Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver', Scientific Reports, vol. 6, article no. 24045, pp. 1-9. Open access 12 11
2016	Galluzzi, L, López-Soto, A, Kumar, S & Kroemer, G 2016, 'Caspases connect cell-death signaling to organismal homeostasis', Immunity, vol. 44, no. 2, pp. 221-231. Open access 309 282 14
2016	Klionsky, D, Abdelmohsen, K, Abe, A, Abedin, MJ, Kumar, S, Morrison, JL & Zughaier, SM and 2460 other authors 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, vol. 12, no. 1, pp. 1-222. Open access 4558 3820 216
2016	Mackenzie, KD, Foot, NJ, Anand, S, Dalton, HE, Chaudhary, N, Collins, BM, Mathivanan, S & Kumar, S 2016, 'Regulation of the divalent metal ion transporter via membrane budding', Cell Discovery, vol. 2, article no. 16011, pp. 1-14. Open access 40 39 1
2016	Shalini, S, Nikolic, A, Wilson, C, Puccini, J, Sladojevic, N, Finnie, J, Dorstyn, L & Kumar, S 2016, 'Caspase-2 deficiency accelerates chemically induced liver cancer in mice', Cell Death and Differentiation, vol. 23, pp.1727-1736. Open access 34 31 10
2016	Wilson, C, Nikolic, A, Kentish, S, Shalini, S, Hatzinikolas, G, Page, A, Dorstyn, L & Kumar, S 2016, 'Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice', Cell Death Discovery, online, vol.2, article no. 16009, pp. 1-10. Open access 15 15 1
2016	Yip, K-H, Kolesnikoff, N, Hauschild, N, Biggs, L, Lopez, AF, Galli, SJ, Kumar, S & Grimbaldeston, MA 2016, 'The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation', Nature Communications, vol. 7, article no.13198, pp. 1-14. Open access 29 28
2015	Boase, NA & Kumar, S 2015, 'NEDD4 : the founding member of a family of ubiquitin-protein ligases', Gene, vol. 557, no. 2, pp. 113-122. Open access 128 125 3
2015	Denton, D & Kumar, S 2015, 'Analyzing the response of RNAI-treated drosophila cells to death stimuli by quantitative real-time polymerase chain reaction', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 666-671. 3 6
2015	Denton, D & Kumar, S 2015, 'Immunostaining using an antibody against active caspase-3 to detect apoptotic cells in drosophila', Cold Spring Harbor Protocols, vol. 6, pp. 576-579. 4
2015	Denton, D & Kumar, S 2015, 'Studying apoptosis in Drosophila', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 609-613. 11
2015	Denton, D & Kumar, S 2015, 'Terminal deoxynucleotidyl transferase (TdT)-mediated dutp nick-end labeling (TUNEL) for detection of apoptotic cells in Drosophila', Cold Spring Harbor Protocols. 19
2015	Denton, D & Kumar, S 2015, 'Using synthetic peptide substrates to measure Drosophila caspase activity', Cold Spring Harbor Protocols, vol. 2015, no. 7, pp. 671-674. 2 1
2015	Denton, D & Kumar, S 2015, 'Using the vital dye acridine orange to detect dying cells in drosophila', Cold Spring Harbor Protocols, vol. 6, pp. 572-574. 11
2015	Denton, DM, Xu, T & Kumar, S 2015, 'Autophagy as a pro-death pathway', Immunology and Cell Biology, vol. 93, pp. 35-42. 162 154 2
2015	Galluzi, L, Bravo-San, PJ, Vitale, I, Aaaronson, S, Kumar, S & Kroemer, G and 102 other authors 2015, 'Essential versus accessory aspects of cell death: recommendations of the NCCD 2015', Cell Death and Differentiation, vol. 22, pp. 58-73. Open access 863 812 33
2015	Galluzzi, L, Pietrocola, F, Bravo-San, PJM, Amaravadi, RK, Kumar, S & Kroemer, G and 18 other authors 2015, 'Autophagy in malignant transformation and cancer progression', The EMBO Journal, vol. 34, no. 7, pp. 856-880. Open access 1064 1003 137
2015	Goel, P, Manning, JA & Kumar, S 2015, 'NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins', Gene, vol. 557, no. 1, pp. 1-10. Open access 144 146 1
2015	Nicolson, S, Denton, D & Kumar, S 2015, 'Ecdysone-mediated programmed cell death in Drosophila', International Journal of Developmental Biology, vol. 59, vol. 1, pp. 23-32. Open access 42 42 1
2015	Peintner, L, Dorstyn, L, Kumar, S, Aneichyk, T, Villunger, A & Manzl, C 2015, 'The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd', Cell Death and Differentiation, vol. 22, pp. 1803-1811. Open access 11 21 7
2015	Wilson, C, Shalini, S, Filipovska, A, Richman, T, Davies, S, Martin, S, McGee, S, Puccini, J, Nikolic, A, Dorstyn, L & Kumar, S 2015, 'Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice', Cell Death and Disease, vol. 6, article no. e1597, pp. 1-31. Open access 38 37 10
2015	Xu, T, Nicolson, S, Denton, D & Kumar, S 2015, 'Distinct requirements of Autophagy-related genes in programmed cell death', Cell Death and Differentiation, vol. 20, no. 11, pp. 1792-1802. Open access 65 59 12
2014	Altin, JA, Daley, SR, Howitt, J, Rickards, HJ, Batkin, AK, Horikawa, K, Prasad, S, Nelms, KA, Kumar, S, Wu, LC, Tan, S-S, Cook, MC & Goodnow, CC 2014, 'Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells', Proceedings of the National Academy of Sciences of USA, vol. 111, no. 6, pp. 2067-2074. Open access 20 21
2014	Camera, D, Boase, NA, Kumar, S, Pow, D V & Poronnik, P 2014, 'Subtle gait abnormalities in Nedd4 heterozygous mice', Behavioural Brain Research, vol. 260, pp. 15-24. 10 9
2014	Dorstyn, L & Kumar, S 2014, 'Caspase-2 protocols', Methods in Molecular Biology, vol. 1133, pp. 71-87. 2
2014	Dorstyn, L, Puccini, J, Nikolic, A, Shalini, S, Wilson, C, Norris, M, Haber, M & Kumar, S 2014, 'An unexpected role for caspase-2 in neuroblastoma', Cell Death and Disease, vol. 5, article no. e1383, pp. 1-9. Open access 21 20
2014	Ekberg, JA, Boase, NA, Rychkov, G, Manning, J, Poronnik, P & Kumar, S 2014, 'Nedd4-2 (NEDD4L) controls intracellular Na+-mediated activity of voltage-gated sodium channels in primary cortical neurons', Biochemical Journal, vol. 457, no. 1, pp. 27-31. Open access 33 33
2014	Sandow, J, Dorstyn, L, O'Reilly, L, Tailler, M, Kumar, S, Strasser, A & Ekert, P 2014, 'ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis', Cell Death and Differentiation, vol. 21, pp. 475-480. Open access 50 46
2014	Shalini, S, Dorstyn, L, Dawar, S & Kumar, S 2014, 'Old, new and emerging functions of caspases', Cell Death and Differentiation, vol. 22, no. 4, pp. 526-539. Open access 1074 1012
2014	Shalini, S, Puccini, J, Wilson, CH, Finnie, J, Dorstyn, LE & Kumar, S 2014, 'Caspase-2 protects against oxidative stress in vivo', Oncogene, vol. 34, no. 38, pp. 4995-5002. Open access 30 26
2013	Denton, D, Aung-Htut, MT & Kumar, S 2013, 'Developmentally programmed cell death in Drosophila', BBA: Molecular Cell Research, vol. 1833, no. 12, pp. 3499-3506. Open access 64 63
2013	Denton, D, Aung-Htut, MT, Lorensuhewa, N, Nicolson, S, Zhu, W, Mills, K, Cakouros, D, Bergmann, A & Kumar, S 2013, 'UTX coordinates steroid hormone-mediated autophagy and cell death', Nature Communications, vol. 4, article no. 2916, pp. 1-11. 53 48
2013	Liu, P, Xu, N, Malyukova, A, Scarlett, C, Kumar, S & Liu, T and 16 other authors 2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, vol. 20, pp. 503-514. Open access 193 173
2013	Puccini, J, Dorstyn, L & Kumar, S 2013, 'Caspase-2 as a tumour suppressor', Cell Death and Differentiation, vol. 20, no. 9, pp. 1133-1139. Open access 87 84
2013	Puccini, J, Shalini, S, Voss, A, Gatei, M, Wilson, C, Hiwase, D, Lavin, M, Dorstyn, L & Kumar, S 2013, 'Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice', Proceedings of the National Academy of Sciences of USA, vol. 110, no. 49, pp. 19920-19925. Open access 62 57
2013	Ronzaud, C, Loffing-Cueni, D, Hausel, P, Debonneville, A, Malsure, SR, Fowler-Jaeger, N, Boase, NA, Perrier, R, Maillard, M, Yang, B, Stokes, JB, Koesters, R, Kumar, S, Hummler, E, Loffing, J & Staub, O 2013, 'Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension', Journal of Clinical Investigation, vol. 123, no. 2, pp. 657-665. Open access 125 127
2013	Scheffner, M & Kumar, S 2013, 'Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects', BBA: Molecular Cell Research, vol. 1843, no. 1, pp. 61-74. Open access 236 225
2013	Wiszniak, S, Kabbara, E, Lumb, R, Scherer, M, Secker, G, Harvey, N, Kumar, S & Schwarz, Q 2013, 'The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties', Developmental Biology, vol. 383, no. 2, pp. 186-200. Open access 25 28
2012	Denton, D, Chang, T-K, Nicolson, S, Shravage, B, Simin, R, Baehrecke, E & Kumar, S 2012, 'Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila', Cell Death and Differentiation, vol. 19, no. 8, pp. 1299-1307. Open access 65 62
2012	Denton, D, Nicolson, S & Kumar, S 2012, 'Cell death by autophagy: facts and apparent artefacts', Cell Death and Differentiation, vol. 19, no. 1, pp. 87-95. Open access 350 337
2012	Dorstyn, L, Puccini, J, Wilson, C, Shalini, S, Nicola, M, Moore, S & Kumar, S 2012, 'Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability', Cell Death and Differentiation, vol. 19, no. 8, pp. 1288-1298. Open access 90 88
2012	Galluzzi, L, Vitale, I, Abrams, J, Alnemri, E, Kumar, S & Kroemer, G and 27 other authors 2012, 'Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012', Cell Death and Differentiation, vol. 19, no. 1, pp. 107-120. Open access 2152 1975
2012	Garrick, MD, Zhao, L, Roth, JA, Jiang, H, Feng, J, Foot, NJ, Dalton, H, Kumar, S & Garrick, LM 2012, 'Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation', Biometals, vol. 25, no. 4, pp. 787-793. Open access 38 34
2012	Howitt, J, Lackovic, J, Low, L-H, Naguib, A, Macintyre, A, Goh, C-P, Callaway, JK, Hammond, V, Thomas, T, Dixon, M, Putz, U, Silke, J, Bartlett, P, Yang, B, Kumar, S, Trotman, LC & Tan, S-S 2012, 'Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia', The Journal of Cell Biology, vol. 196, no. 1, pp. 29-36. Open access 92 89
2012	Klionsky, DJ, Abdalla, FC, Abeliovich, H, Abraham, RT, Denton, D, Kumar, S & Zuckerbraun, B and 1264 other authors 2012, 'Guidelines for the use and interpretation of assays for monitoring autophagy', Autophagy, vol. 8, no. 4, pp. 445-544. 2978 2662
2012	Shalini, S, Dorstyn, L, Wilson, C, Puccini, J, Ho, L & Kumar, S 2012, 'Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice', Cell Death and Differentiation, vol. 19, no. 8, pp. 1370-1380. Open access 78 69
2011	Boase, NA, Rychkov, G, Townley, S, Dinudom, A, Candi, E, Voss, A, Tsoutsman, T, Semsarian, C, Melino, G, Koentgen, F, Cook, D & Kumar, S 2011, 'Respiratory distress and perinatal lethality in Nedd4-2-deficient mice', Nature Communications, vol. 2, no. 287, pp. 1-9. Open access 83 78
2011	Dalton, H, Denton, D, Foot, N, Ho, K, Mills, K, Brou, C & Kumar, S 2011, 'Drosophila Ndfip is a novel regulator of Notch signaling', Cell Death and Differentiation, vol. 18, no. 7, pp. 1150-1160. 19 20
2011	Foot, NJ, Leong, YA, Dorstyn, LE, Dalton, HE, Ho, K, Zhao, L, Garrick, MD, Yang, B, Hiwase, D & Kumar, S 2011, 'Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis', Blood, vol. 117, no. 2, pp. 638-646. Open access 41 39
2011	Lee, I-H, Song, S-H, Campbell, CR, Kumar, S, Cook, D I & Dinudom, A 2011, 'Regulation of the epithelial Na⁺ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Gαq/11', Journal of Biological Chemistry, vol. 286, no. 22, pp. 19259-19269. Open access 13 11
2011	Yuan, S, Yu, X, Topf, M, Dorstyn, LE, Kumar, S, Ludtke, S & Akey, C 2011, 'Structure of the drosophila apoptosome at 6.9 A resolution', Structure, vol. 19, no. 1, pp. 128-140. Open access 71 65
2010	Denton, D, Shravage, B V, Simin, R, Baehrecke, EH & Kumar, S 2010, 'Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy', Autophagy, vol. 6, no. 1, pp. 163-165. Open access 54 51
2010	Hiwase, D, White, D, Powell, J, Saunders, V, Zrim, S, Frede, A, Guthridge, M, Lopez, A, D'Andrea, R, To, L, Melo, J, Kumar, S & Hughes, T 2010, 'Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors', Leukemia, vol. 24, no. 4, pp. 771-778. 48 42
2010	Manning, J & Kumar, S 2010, 'A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts', Cell Death and Disease, vol. 1, no. 4, pp. 1-8. Open access 29 31
2010	Manning, J, Lewis, M, Koblar, S & Kumar, S 2010, 'An essential function for the centrosomal protein NEDD1 in zebrafish development', Cell Death and Differentiation, vol. 17, no. 8, pp. 1302-1314. Open access 13 13
2010	Manning, JA, Shalini, S, Risk, J, Day, C & Kumar, S 2010, 'A direct interaction with NEDD1 regulates Gamma-tubulin recruitment to the centrosome', PLoS One, vol. 5, no. 3, pp. 1-12. Open access 39 41
2010	Yang, B & Kumar, S 2010, 'Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions', Cell Death and Differentiation, vol. 17, no. 1, pp. 68-77. Open access 194 192
2009	Denton, D, Shravage, B, Simin, R, Mills, K, Berry, DL, Baehrecke, EH & Kumar, S 2009, 'Autophagy, not apoptosis, is essential for midgut cell death in Drosophila', Current Biology, vol. 19, no. 20, pp. 1741-1746. Open access 327 320
2009	Dorstyn, L & Kumar, S 2009, 'Putative functions of caspase-2', F1000 Biology Reports, vol. 1, no. 96, pp. 1-5. Open access
2009	Ho, LH, Taylor, R, Dorstyn, L, Cakouros, D, Bouillet, P & Kumar, S 2009, 'A tumor suppressor function for caspase-2', Proceedings of the National Academy of Sciences of USA, vol. 106, no. 13, pp. 5336-5341. Open access 152 142
2009	Howitt, J, Putz, U, Lackovic, J, Doan, A, Dorstyn, L, Cheng, H, Yang, B, Chan-Ling, T, Silke, J, Kumar, S & Tan, S-S 2009, 'Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons', Proceedings of the National Academy of Sciences of USA, vol. 106, no. 36, pp. 15489-15494. Open access 102 100
2009	Kochetkova, M, Kumar, S & McColl, SR 2009, 'Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells', Cell Death and Differentiation, vol. 16, no. 5, pp. 664-673. Open access 87 83
2009	Kroemer, G, Galluzzi, L, Vandenabeele, P, Abrams, J, Kumar, S & Melino, G and 16 other authors 2009, 'Classification of cell death : recommendations of the Nomenclature Committee on Cell Death 2009', Cell Death and Differentiation, vol. 16, no. 1, pp. 3-11. Open access 2473 2371
2009	Kumar, S & Dorstyn, LE 2009, 'Analysing caspase activation and caspase activity in apoptotic cells', Methods in Molecular Biology, vol. 559, pp. 3-17. 16 11
2009	Kumar, S & Saini, R 2009, 'CFD based performance analysis of a solar air heater duct provided with artificial roughness', Renewable Energy, vol. 34, no. 5, pp. 1285-1291. 221
2009	Kumar, S 2009, 'Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?', Nature Reviews Cancer, vol. 9, no. 12, pp. 897-903. 124 125
2009	Lee, I-H, Campbell, CR, Song, S-H, Day, ML, Kumar, S, Cook, D I & Dinudom, A 2009, 'The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism', Journal of Biological Chemistry, vol. 284, no. 19, pp. 12663-12669. Open access 50 45
2009	Rotin, D & Kumar, S 2009, 'Physiological functions of the HECT family of ubiquitin ligases', Nature Reviews Molecular Cell Biology, vol. 10, no. 6, pp. 398-409. Open access 894 859
2008	Colussi, P, Manning, JA, Koblar, SA & Kumar, S 2008, 'Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development', Histochemistry and Cell Biology, vol. 129, no. 6, pp. 751-764. 14 15
2008	Denton, DM, Daish, T, Kumar, S, Mills, KM, Cakouros, D & Paterson, A 2008, 'dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes', The Journal of Cell Biology, vol. 182, no. 3, pp. 481-495. Open access 26 25
2008	Denton, DM, Kumar, S & Mills, KM 2008, 'Methods and Protocols for Studying Cell Death in Drosophila', Methods in Enzymology, vol. 446, pp. 17-37. 32 31
2008	Dorstyn, LE & Kumar, S 2008, 'A biochemical analysis of the activation of the Drosophila caspase DRONC', Cell Death and Differentiation, vol. 15, no. 3, pp. 461-470. Open access 53 48
2008	Dorstyn, LE, Kumar, S, Yang, B, Dalton, H, Foot, NJ, Tan, S & Shearwin-Whyatt, L 2008, 'Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2', Blood, vol. 112, no. 10, pp. 4268-4275. Open access 124 118
2008	Ho, L, Read, S, Dorstyn, LE, Lambrusco, L & Kumar, S 2008, 'Caspase-2 is required for cell death induced by cytoskeletal disruption', Oncogene, vol. 27, no. 24, pp. 3393-3404. 111 104
2008	Hughes, TP, Dang, P, Hewett, D, Zrim, S, White, DL, To, L, Eadie, L, Saunders, V, Kumar, S, Melo, J, Frede, A & Hiwase, D 2008, 'Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications', Clinical Cancer Research, vol. 14, no. 12, pp. 3881-3888. Open access 168 152
2008	Kumar, S, Croucher, D, Kirby, P, Boase, NA, Daly, R, Cao, X, Place, T, Sweezer, E, Lill, N, Yang, B, Shi, P, Qu, J & Shan, H 2008, 'Nedd4 controls animal growth by regulating IGF-1 signaling', Science Signaling, vol. 1, no. 38. Open access 142 136
2008	Kumar, S, Poronnik, P, Admas, D & Schuetz, F 2008, 'Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1', American Journal of Physiology: Cell Physiology, vol. 295, no. 1, pp. 73-80. 25 24
2008	Silke, J, Putz, U, Tan, S, Foot, NJ, Howitt, J, Lackovic, J & Kumar, S 2008, 'Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins', Journal of Biological Chemistry, vol. 283, no. 47, pp. 32621-32627. Open access 145 137

External engagement & recognition

Collaborations

Highlights

PROFESSIONAL RECOGNITION

Fellowships of the Learned Academies

Fellow of the Australian Academy of Science (FAA)

Fellow of the Australian Academy of Health and Medical Sciences (FAHMS)

International and National Fellowships

NHMRC Level 3 Investigator (2022-Current)

NHMRC Senior Principal Research Fellow (2004-2021)

NHMRC Principal Research Fellow (2001-2003)

Wellcome Trust (UK) Senior Fellow in Medical Science (1996-2000)

Florey Research Fellow

Japanese Science and Technology Agency (STA) Fellow

University of Queensland Postdoctoral Fellow

Significant Awards and Prizes

Bradley Distinguished Professor

South Australian Scientist of the Year

Member of the Order of Australia

ANZSCDB President's Medal

FAOBMB Award for Research Excellence

ASBMB Lemberg Medal

Ranbaxy Science Foundation Award in Basic Medical Sciences

External engagement & recognition

Collaborations

Organisation	Country
Ain Shams University	EGYPT
AstraZeneca	AUSTRALIA
Australian National University	AUSTRALIA
Baker Heart and Diabetes Institute	AUSTRALIA
Baylor College of Medicine	UNITED STATES
Boston University	UNITED STATES
Candiolo Cancer Institute	ITALY
Centro de Investigaciones Biológicas	SPAIN
Childrens Cancer Institute Australia for Medical Research	AUSTRALIA
Cold Spring Harbor Laboratory	UNITED STATES
Cordeliers Research Centre (France)	FRANCE
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Deakin University	AUSTRALIA
Duke University	UNITED STATES
Emory University	UNITED STATES
Federal University of Sao Carlos	BRAZIL
Federico II University	ITALY
Flinders Medical Centre	AUSTRALIA
Florey Neuroscience Institute	AUSTRALIA
Garvan Institute of Medical Research	AUSTRALIA
Genentech	UNITED STATES
Georgetown University	UNITED STATES
Ghent University	BELGIUM
Griffith University	AUSTRALIA
Hanson Institute	AUSTRALIA
Harry Perkins Institute of Medical Research	AUSTRALIA
Harvard University	UNITED STATES
Hebrew University	MEXICO
Hong Kong Baptist University	HONG KONG
Hudson Institute of Medical Research	AUSTRALIA
Icahn School of Medicine at Mount Sinai	UNITED STATES
Indian Institute of Technology Roorkee	INDIA
Institute of Medical and Veterinary Science	AUSTRALIA
Jilin University	CHINA
Johannes Gutenberg University of Mainz	GERMANY
Johns Hopkins University	UNITED STATES
Kanazawa University	JAPAN
Kanazawa University Hospital	JAPAN
Karolinska Institute	SWEDEN
Keio University	JAPAN
La Trobe University	AUSTRALIA
Lausanne University Hospital	FRANCE
Max Planck Institute of Experimental Medicine	GERMANY
Mayo Clinic	UNITED STATES
Medical University of Graz	AUSTRIA
Medical University of Innsbruck	AUSTRIA
Monash University	AUSTRALIA
National Institute on Aging	UNITED STATES
National Institutes of Health	MALAYSIA
New York University	UNITED STATES
Okayama University	JAPAN
Osaka University	JAPAN
Ozgene	AUSTRALIA
Pavlov University	RUSSIAN FEDERATION
Peter MacCallum Cancer Centre	AUSTRALIA
Pfizer Worldwide Research and Development	UNITED STATES
Pierre and Marie Curie University	FRANCE
Queensland Institute of Medical Research	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Regina Elena National Cancer Institute	ITALY
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal North Shore Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
SA Water	AUSTRALIA
Sapienza University of Rome	ITALY
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
South Australian Health and Medical Institute	AUSTRALIA
St. Jude Children's Research Hospital	UNITED STATES
Stanford University	UNITED STATES
State University of New York Buffalo	UNITED STATES
Technion Israel Institute of Technology	ISRAEL
The Hospital for Sick Children	CANADA
The Institut Pasteur (AKA L'Institut Pasteur)	FRANCE
Thomas Jefferson University	UNITED STATES
Tokyo Medical Dental University	JAPAN
Tokyo Medical University	JAPAN
Trinity College Dublin	IRELAND
University of Adelaide	AUSTRALIA
University Of Angers	FRANCE
University of Cambridge	UNITED KINGDOM
University of Cologne	GERMANY
University of Geneva	SWITZERLAND
University of Iowa	UNITED STATES
University of Konstanz	GERMANY
University of Lausanne	SWITZERLAND
University of London	FRANCE
University of Massachusetts Amherst	UNITED STATES
University of Massachusetts Chan Medical School	UNITED STATES
University of Massachusetts Medical School	UNITED STATES
University of Melbourne	AUSTRALIA
University of Michigan	UNITED STATES
University of Minnesota, Twin Cities	UNITED STATES
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Otago	NEW ZEALAND
University of Oxford	UNITED KINGDOM
University Of Paris Sud (Paris 11)	FRANCE
University of Pennsylvania	UNITED STATES
University of Pittsburgh	UNITED STATES
University of Queensland	AUSTRALIA
University of Rome Tor Vergata	ITALY
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Texas Southwestern Medical Center	UNITED STATES
University of Western Australia	AUSTRALIA
University of Zurich	SWITZERLAND
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Weill Cornell Medical College	UNITED STATES
Weill Cornell Medicine - Qatar (Medbay)	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
South Australian Scientist of the Year, 2020 SA Science Excellence and Innovation Awards	2021
Fellowship Selection Committee Australian Academy of Science	2020
Member, National Committee for Biomedical Sciences Australian Academy of Science	2020
Fellowship Selection Committee Australian Academy of Science	2019
Member, National Committee for Biomedical Sciences Australian Academy of Science	2019
President Australia and New Zealand Society for Cell and Developmental Biology	2019
Scientist of the year - nomination SA Science Excellence Awards	2019
Affiliate Professor of Medicine The University of Adelaide	2018
Associate Editor Molecular and Cellular Oncology	2018
Board Member International Cell Death Society	2018
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2018
Editorial Advisory Board Oncotarget	2018
Editorial Board Member Cell Death and Differentiation	2018
Editorial Board Member ScienceOPEN	2018
Editorial Board Member Frontiers in Cancer Molecular Targets and Therapeutics	2018
Fellowship Selection Committee Australian Academy of Science	2018
Finalist, South Australian Scientist of the Year Award Government of South Australia	2018
Member American Society for Biochemistry and Molecular Biology	2018
Member Faculty of 1000	2018
Member European Cell Death Organization	2018
Member Research Strategy Group of the Beat Cancer Project	2018
Member Japan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA)	2018
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2018
Member of the Order of Australia (AM) Order of Australia	2018
Member, National Committee for Biomedical Sciences Australian Academy of Science	2018
President Australia and New Zealand Society for Cell and Developmental Biology	2018
SAIMA President Award South Australian Indian Medical Association (SAIMA)	2018
Affiliate Professor of Medicine The University of Adelaide	2017
Associate Editor Molecular and Cellular Oncology	2017
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2017
Editorial Advisory Board Oncotarget	2017
Editorial Board Member Cell Death and Differentiation	2017
Editorial Board Member ScienceOPEN	2017
Editorial Board Member Frontiers in Cancer Molecular Targets and Therapeutics	2017
Fellowship Selection Committee Australian Academy of Science	2017
Member American Society for Biochemistry and Molecular Biology	2017
Member European Cell Death Organization	2017
Member Faculty of 1000	2017
Member Australian Society for Biochemistry and Molecular Biology (ASBMB)	2017
Member Research Strategy Group of the Beat Cancer Project	2017
Member Japan Society for the Promotion of Science Alumni Association in Australia (JSPSAAA)	2017
Member, National Committee for Biomedical Sciences Australian Academy of Science	2017
President Australia and New Zealand Society for Cell and Developmental Biology	2017
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2017
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2016
President's Medal Australia and New Zealand Society for Cell and Developmental Biology	2016
Senior Principal Research Fellowship National Health and Medical Research Council (NHMRC)	2016
Fellow Australian Academy of Health and Medical Science	2015
Fellowship Australia and New Zealand Society for Cell and Developmental Biology	2015
Member, Grant Reviewing Panels National Health and Medical Research Council (NHMRC)	2015
President-elect and council member Australia and New Zealand Society for Cell and Developmental Biology	2015
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2014
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2013
Fellow Australian Academy of Science	2013
Lamberg Medal Australian Society for Biochemistry and Molecular Biology (ASBMB)	2013
Member of learned academy Australian Academy of Science	2013
Research Excellence Federation of Asian and Oceanian Biochemists and Molecular Biologists	2013
Committee member, Assigners Academy National Health and Medical Research Council (NHMRC)	2012

Other

Editorial Boards, Advisory Committees, Professional Societies and Peer Review Panels

Associate Editor, Journal of Extracellular Vesicles (appointed Nov 2024)

Member, Australian Research Council College of Experts (appointed Nov 2024)

Member, Australian Academy of Science Sectional Committee SC9 (2023-2026)

Member, Selection Committee for the AAHMS Jian Zhou Medal (2023-2025)

Member, NHMRC Investigator (L1-L3) Grants Review Panel (2019, 2022, 2023, 2024)

Member, Program Committee for 26th Congress of IUBMB (2022-2024)

Member, Award Selection Panel, Australasian Society of Cell Death (2020, 2021, 2022)

Member, Beat Cancer Project Research Strategy Group, Cancer Council SA (2017- current)

Member of the Board, International Society of Cell Death (2018- current)

Member, Steering Committee of Research Centre for Extracellular Vesicles (RCEV) (2021- current)

Member, Australian Academy of Science National Committee for Biomedical Sciences (2017- 2024)

Member, Selection Panel, SA Science Excellence and Innovation Awards (2021, 2022, 2023)

ACDS Pioneer and Advisor, Australasian Cell Death Society (2020- current)

Member, International Society of Extracellular Vesicles (2020- current)

Member, American Society for Biochemistry and Cell Biology (ASBMB) (1997- current)

Member, Australian Society for Biochemistry and Cell Biology (ASBMB) (1996- current)

Member, American Association for Advancement of Science (AAAS) (1995- current)

Member, Ausbiotech (2019- current)

Member, National Association of Research Fellows (NARF) (2000- current)

Member, Editorial Board, Cell Death & Differentiation (1996- current)

Member, Faculty of 1000 (2001- current)

Member, ANZSCDB Committee (2019- current)

Executive and Past-President, ANZSCDB (2019-2021)

President, Australia and New Zealand Society for Cell and Developmental Biology (ANZSCDB) (2017-2019)

Member, AAS Sectional Committee SC8 (2017-2020)

Member, NHMRC Assigners Academy (2012, 2013, 2014, 2017, 2018)

Member, NHMRC Grant Reviewing Panels (GRP) (2001, 2002, 2004, 2010, 2011, 2015)

Member, NHMRC Academy (2011)

Member, Cancer Australia Grant Review Panel (2009)

Member, RAH/IMVS Research Committee (2005-2009)

Chair, RAH/IMVS Research Fellowship Sub-Committee (2005-2009)

Chair, NHMRC GRP (2006, 2007)

Deputy Chair, NHMRC GRP (2005)

Member, Cancer Council Research Advisory Committee (1999-2001)

Member, NHMRC Regional Grants Interviewing Committee (1999)

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Exploring the mechanisms of age-related polyploidy in inflammation and liver cancer	Current
Identification and characterisation of NEDD4-2 regulated proteins in the renal tubular epithelia.	Current
Modulation of NEDD4-2 expression and activity as a cellular mechanism for ameliorating kidney disease	Current
New mechanisms regulating extracellular vesicle biogenesis	Current
Regulation of autophagy in cell and tissue homeostasis	Current
Analysis of Arrdc4 ubiquitination and its function in extracellular vesicles biogenesis	Completed
Deciphering the role of caspase-2 in protecting against genetic instability and tumour suppression	Completed
Identifying regulators of autophagy-dependent cell death	Completed
Investigating the role of NEDD4 in neural crest cell development and craniofacial bone formation	Completed
Regulation and mechanism of autophagy-dependent developmental cell death in Drosophila melanogaster larval midgut	Completed
Regulation of retromer and its role in tauopathies	Completed
The role for caspase-2 in mammary development and fat biology	Completed

Professor Sharad Kumar

Alternative contact

Alternative contact details

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Chapters

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

South Australian Scientist of the Year, 2020

Fellowship Selection Committee

Member, National Committee for Biomedical Sciences

Fellowship Selection Committee

Member, National Committee for Biomedical Sciences

President

Scientist of the year - nomination

Affiliate Professor of Medicine

Associate Editor

Board Member

Committee member, Assigners Academy

Editorial Advisory Board

Editorial Board Member

Editorial Board Member

Editorial Board Member

Fellowship Selection Committee

Finalist, South Australian Scientist of the Year Award

Member

Member

Member

Member

Member

Member

Member of the Order of Australia (AM)

Member, National Committee for Biomedical Sciences

President

SAIMA President Award

Affiliate Professor of Medicine

Associate Editor

Committee member, Assigners Academy

Editorial Advisory Board

Editorial Board Member

Editorial Board Member

Editorial Board Member

Fellowship Selection Committee

Member

Member

Member

Member

Member

Member

Member, National Committee for Biomedical Sciences

President

President-elect and council member

President-elect and council member

President's Medal

Senior Principal Research Fellowship

Fellow

Fellowship

Member, Grant Reviewing Panels

President-elect and council member

Committee member, Assigners Academy

Committee member, Assigners Academy

Fellow

Lamberg Medal

Member of learned academy

Research Excellence