Associate Professor Stephanie Reuter Lange

Associate Research Professor UniSA Clinical & Health Sciences

City East Campus (P5-29)
tel +61 8 830 21872

email Stephanie.ReuterLange@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

Translational Pharmacology
Clinical Pharmacokinetics
Pharmacometrics
Dose Optimisation
Quality Use of Medicines

As a clinical pharmacokineticist, A/Prof Stephanie Reuter Lange’s research portfolio broadly focusses on using pharmacological principles to inform the optimal use of medications. Appropriately, through this activity she works extensively with pharmaceutical industry and regulatory agencies in the development of new drug entities, as well as clinicians and pharmacists to improve the use of existing drugs for better management of patients in clinical practice. Her research philosophy is one of translation, specifically bridging the interface between foundational science and clinical practice, acting as a conduit between science, policy and the clinic.

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

Tweets by @UniversitySA

Research

Highlights

Stephanie currently holds Cancer Council Mid-Career Fellowship, which aims to address the medication issues associated with the sub-optimal use of anti-cancer agents and develop rational, evidence-based guidelines for the appropriate prescription of these drugs in clinical practice. She has previously been awarded a prestigious Fulbright Visiting Research Scholarship to undertake research with world leaders in the field of PK/PD modelling at the State University of New York, using innovative techniques to inform the quality use of medicines.

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2023	Carland, JE, Stacy, AE, Schaffer, AL, Day, RO, Brett, J, Reuter, SE & Stocker, SL 2023, 'Blood, dose recommendation reports and phone calls: experiences of a therapeutic drug monitoring advisory service for vancomycin', British Journal of Clinical Pharmacology, online, pp. 1-7. Open access
2022	Chughlay, MF, Barnes, K I, El Gaaloul, M, Abla, N, Mohrle, JJ, Griffin, P, van Giersbergen, P, Reuter, SE, Schultz, HB, Kress, A, Tapley, P, Webster, RA, Wells, T, McCarthy, JS, Barber, BE, Marquart, L, Boyle, MJ, Engwerda, CR & Chalon, S 2022, 'Safety, tolerability, pharmacokinetics, and pharmacodynamics of coadministered ruxolitinib and artemether-lumefantrine in healthy adults', Antimicrobial Agents and Chemotherapy, vol. 66, no. 1, article no. e01584-21, pp. 1-13. Open access 2 3 1
2022	Larcombe, R, Coulthard, K, Eaton, V, Tai, A, Reuter, S & Ward, M 2022, 'Is there a multinational consensus of tobramycin prescribing and monitoring for cystic fibrosis? Survey of current therapeutic drug monitoring practices in USA/Canada, UK/Ireland, and Australia/New Zealand', European Journal of Hospital Pharmacy: Science and Practice, online, pp. 1-6.
2022	Reuter, SE, Stocker, SL, Alffenaar, J-WC, Baldelli, S, Cattaneo, D, Jones, G, Koch, BC, Kocic, D, Mathew, SK, Molinaro, M, Neely, M, Sandaradura, I & Marriott, DJ 2022, 'Optimal practice for vancomycin therapeutic drug monitoring: position statement from the anti-infectives committee of the international association of therapeutic drug monitoring and clinical toxicology', Therapeutic Drug Monitoring, vol. 44, no. 1, pp. 121-132. 5 5 9
2022	Schultz, HB, Hosseini, A, McLachlan, AJ & Reuter, SE 2022, 'Population pharmacokinetics of oral-based administration of cannabidiol in healthy adults: implications for drug development', Cannabis and Cannabinoid Research, online, pp. 1-10.
2022	Wong, DD, van Zuylen, WJ, Novos, T, Stocker, S, Reuter, SE, Au, J, Foster, CS, Day, RO, Horvath, AR, Endre, Z & Rawlinson, WD 2022, 'Detection of ganciclovir-resistant cytomegalovirus in a prospective cohort of kidney transplant recipients receiving subtherapeutic valganciclovir prophylaxis', Microbiology Spectrum, vol. 10, no. 3, pp. 1-10. Open access 1
2022	Wong, S, Reuter, SE, Jones, GR & Stocker, SL 2022, 'Review and evaluation of vancomycin dosing guidelines for obese individuals', Expert Opinion on Drug Metabolism and Toxicology, vol. 18, no. 5, pp. 323-335. 7
2021	Lau, C, Marriott, D, Schultz, HB, Gould, M, Andresen, D, Wicha, SG, Alffenaar, JW, Penm, J & Reuter, SE 2021, 'Assessment of cefepime toxicodynamics: comprehensive examination of pharmacokinetic/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines', International Journal of Antimicrobial Agents, vol. 58, article no. 106443. 7 8 35
2021	Menz, BD, Stocker, SL, Verougstraete, N, Kocic, D, Galettis, P, Stove, CP & Reuter, SE 2021, 'Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology', British Journal of Clinical Pharmacology, vol. 87, no. 2, pp. 227-236. Open access 14 13 3
2021	Reuter, SE, Schultz, HB, Ward, MB, Grant, C, Paech, GM, Banks, S & Evans, AM 2021, 'The effect of high-dose, short-term caffeine intake on the renal clearance of calcium, sodium and creatinine in healthy adults', British Journal of Clinical Pharmacology, vol. 87, no. 11, pp. 4461-4466. Open access 1 159
2021	Roydhouse, SA, Carland, JE, Debono, DS, Baysari, MT, Reuter, SE, Staciwa, AJ, Sandhu, AP, Day, RO & Stocker, SL 2021, 'Accuracy of documented administration times for intravenous antimicrobial drugs and impact on dosing decisions', British Journal of Clinical Pharmacology, vol. 87, no. 11, pp. 4273-4282. 4 5 1
2021	Sandaradura, I, Marriott, DJ, Day, RO, Norris, RL, Pang, E, Stocker, SL & Reuter, SE 2021, 'Current fluconazole treatment regimens result in under-dosing of critically ill adults during early therapy', European Journal of Clinical Microbiology and Infectious Diseases: An International Journal on Pathogenesis, Diagnosis, Epidemiology, Therapy, and Prevention of Infectious Diseases, vol. 40, no. 7, pp. 1521-1528. 2 2 8
2021	Sandaradura, I, Wojciechowski, J, Marriott, DJ, Day, RO, Stocker, S & Reuter, SE 2021, 'Model-optimized fluconazole dose selection for critically ill patients improves early pharmacodynamic target attainment without the need for therapeutic drug monitoring', Antimicrobial Agents and Chemotherapy, vol. 65, no. 3, pp. 1-10. Open access 5 4 1
2021	Stocker, SL, Carland, JE, Reuter, SE, Stacy, AE, Schaffer, AL, Stefani, M, Lau, C, Kirubakaran, R, Yang, JJ, Shen, CF, Roberts, DM, Marriott, DJ, Day, RO & Brett, J 2021, 'Evaluation of a pilot vancomycin precision dosing advisory service on target exposure attainment using an interrupted time series analysis', Clinical Pharmacology and Therapeutics, 109, no. 1, pp. 212-221. Open access 12 10 5
2020	Harris, BD, Phan, V, Perera, V, Szyc, A, Galettis, P, Martin, JH, Walpole, E, McLachlan, A, Clarke, SJ, Reuter, SE & Charles, KA 2020, 'Inability of current dosing to achieve carboplatin therapeutic targets in people with advanced non-small cell lung cancer: impact of systemic inflammation on carboplatin exposure and clinical outcomes', Clinical Pharmacokinetics, vol. 59, no. 8, pp. 1013-1026. Open access 3 3 2
2020	Lau, C, Marriott, D, Gould, M, Andresen, D, Reuter, SE & Penm, J 2020, 'A retrospective study to determine the cefepime-induced neurotoxicity threshold in hospitalized patients', Journal of Antimicrobial Chemotherapy, vol. 75, no. 3, pp. 718-725. Open access 26 30 14
2020	Shingde, R V, Reuter, SE, Graham, GG, Carland, JE, Williams, KM, Day, RO & Stocker, SL 2020, 'Assessing the accuracy of two Bayesian forecasting programs in estimating vancomycin drug exposure', Journal of Antimicrobial Chemotherapy, vol. 75, no. 11, pp. 3293-3302. 14 15 7
2020	Teng, C, Reuter, SE, Blinman, PL, Dhillon, HM, Galettis, P, Proschogo, N, McLachlan, AJ & Vardy, JL 2020, 'Ibudilast for prevention of oxaliplatin-induced acute neurotoxicity: a pilot study assessing preliminary efficacy, tolerability and pharmacokinetic interactions in patients with metastatic gastrointestinal cancer', Cancer Chemotherapy and Pharmacology, vol. 86, no. 4, pp. 547-558. 2 3 109
2019	Hughes, JH, Phelps, MA, Upton, RN, Reuter Lange, SE, Gao, Y, Byrd, JC, Grever, MR, Hofmeister, CC, Marcucci, G, Blum, W, Blum, KA & Foster, DJ 2019, 'Population pharmacokinetics of lenalidomide in patients with B-cell malignancies', British Journal of Clinical Pharmacology, vol. 85, no. 5, pp. 924-934. Open access 5 5 4
2019	Hughes, JH, Upton, RN, Reuter, SE, Phelps, MA & Foster, DJ 2019, 'Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis', Journal of Pharmacy and Pharmacology, vol. 71, no. 11, pp. 1635-1644. 5 5 1
2019	Hughes, JH, Upton, RN, Reuter, SE, Rozewski, DM, Phelps, MA & Foster, DJ 2019, 'Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice', Cancer Chemotherapy and Pharmacology, vol. 84, no. 5, pp. 1073-1087. Open access 4 4
2019	Milliken, E, de Zwart, AE, Alffenaar, J-WC, Marriott, DJ, Riezebos-Brilman, A, Schteinman, A, Evans, AM, Glanville, AR, Verschuuren, EA & Reuter, SE 2019, 'Population pharmacokinetics of ribavirin in lung transplant recipients and examination of current and alternative dosing regimens', Journal of Antimicrobial Chemotherapy, vol. 74, no. 3, pp. 691-698. Open access 2 3 1
2019	Reuter, SE, Evans, AM & Ward, MB 2019, 'Reducing palivizumab dose requirements through rational dose regimen design', CPT: Pharmacometrics and Systems Pharmacology, vol. 8, no. 1, pp. 26-33. Open access 4
2019	Shingde, R V, Graham, GG, Reuter, SE, Carland, JE, Day, RO & Stocker, SL 2019, 'Comparison of the area under the curve for vancomycin estimated using compartmental and noncompartmental methods in adult patients with normal renal function', Therapeutic Drug Monitoring, vol 41, no. 6, pp. 726-731. 10 8 3
2018	Lucas, CJ, Galettis, P, Song, S, Solowij, N, Reuter, SE, Schneider, J & Martin, JH 2018, 'Cannabinoid disposition after human intraperitoneal use: an insight into intraperitoneal pharmacokinetic properties in metastatic cancer', Clinical Therapeutics: The International Peer-Reviewed Journal of Drug Therapy, vol. 40, no. 9, pp. 1442-1447. Open access 7 7 6
2016	Reuter, SE & Martin, JH 2016, 'Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome', Clinical Pharmacokinetics, vol. 55, no. 7, pp. 807-812. Open access 29 28 2
2016	Ward, MB, Reuter, SE & Martin, JH 2016, 'How 'optimal' are optimal sampling times for tyrosine kinase inhibitors in cancer? Practical considerations', Clinical Pharmacokinetics, vol. 55, no. 10, pp 1171–1177. 6 5
2015	Reuter, SE, Evans, AM, Shakib, S, Lungershausen, Y, Francis, B, Valentini, G, Bacchieri, A, Ubben, D & Pace, S 2015, 'Effect of food on the pharmacokinetics of piperaquine and dihydroartemisinin', Clinical Drug Investigation, vol. 35, no. 9, pp. 559-567. Open access 18 18 1
2014	Fooladi, E, Reuter, SE, Bell, RJ, Robinson, PJ & Davis, SR 2014, 'Pharmacokinetics of a transdermal testosterone cream in healthy postmenopausal women', Menopause: The Journal of the North American Menopause Society, vol. 20, no. 1, pp. 44-49. Open access 17 14 28
2014	Reuter, SE, Upton, RN, Evans, AM, Navaratnam, V & Olliaro, PL 2014, 'Population pharmacokinetics of orally administered mefloquine in healthy volunteers and patients with uncomplicated Plasmodium falciparum malaria', Journal of Antimicrobial Chemotherapy, vol. 70, no. 3, pp. 868-876. Open access 13 13 2
2012	Reuter, SE & Evans, AM 2012, 'Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects', Clinical Pharmacokinetics, vol. 51, no. 9, pp. 553-572. Open access 279 270 7
2012	Wiese, MD, Sluggett, JK, Wilson, CJ, Reuter, SE, Turner, SC & Evans, AM 2012, 'Perceived and actual paracetamol dosing in overweight and obese children', European Journal of Hospital Pharmacy: Science and Practice, vol. 19, no. 5, pp. 438-442. 2 2 4
2011	Reuter, LSE, Massy-Westropp, NM & Evans, AM 2011, 'Reliability and validity of indices of hand-grip strength and endurance', Australian Occupational Therapy Journal, vol. 58, no. 2, pp. 82-87. 45 38
2011	Reuter, S & Evans, A 2011, 'Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activity', Journal of Internal Medicine, vol. 270, no. 1, pp. 76-84. Open access 28 24
2010	Olliaro, P, Ramanathan, S, Vaillant, M, Reuter, LSE, Evans, AM, Krudsood, S, Looareesuwan, S, Kiechel, JR, Taylor, W & Navaratnam, V 2010, 'Pharmacokinetics and comparative bioavailability of artesunate and mefloquine administered separately or as a fixed combination product to healthy volunteers and patients with uncomplicated plasmodium falciparum malaria', Journal of Bioequivalence and Bioavailability, vol. 2, no. 3, pp. 59-66. Open access
2009	Reuter, LSE, Faull, R, Ranieri, E & Evans, AM 2009, 'Endogenous plasma carnitine pool composition and response to erythropoietin treatment in chronic haemodialysis patients', Nephrology Dialysis Transplantation, vol. 24, no. 3, pp. 990-996. Open access 31 30
2008	Reuter Lange, SE, Evans, AM, Chace, D & Fornasini, G 2008, 'Determination of the reference range of endogenous plasma carnitines in healthy adults', Annals of Clinical Biochemistry, vol. 45, no. 6, pp. 585-592. 45 44
2008	Reuter, SE, Faull, RJ & Evans, AM 2008, 'L-carnitine supplementation in the dialysis population: are Australian patients missing out?', Nephrology, vol. 13, no. 1, pp. 3-16. 26 25

Reports

Year	Output
2021	Ward, M, Reuter Lange, S & Staff, K 2021, International biosimilar medicines catalogue and summary of published literature: quarterly update October-December 2020, GBMA Education, Australia. Open access
2020	Ward, M, Reuter Lange, S & Staff, K 2020, International biosimilar medicines review of the literature: quarterly update January 2020 - March 2020, GBMA Education, Australia. Open access
2020	Ward, M, Reuter Lange, S & Staff, K 2020, International biosimilar medicines review of the literature: quarterly update October 2019 - December 2019, GBMA Education, Australia. Open access
2020	Ward, M, Reuter Lange, S & Staff, K 2020, International biosimilar medicines review of the literature: quarterly update: quarterly update July-September 2020, GBMA Education, Australia. Open access
2020	Ward, M, Reuter Lange, S & Staff, K 2020, International biosimilar medicines: catalogue and summary of published literature: quarterly update April 2020 - June 2020, GBMA Education, Australia, Australia. Open access
2019	Ward, M, Reuter Lange, S & Staff, K 2019, International biosimilar medicines review of the literature: quarterly update April 2019 - June 2019, GBMA Education, Australia. Open access
2019	Ward, M, Reuter Lange, S & Staff, K 2019, International biosimilar medicines review of the literature: quarterly update January 2019 - March 2019, GBMA Education, Australia. Open access
2019	Ward, M, Reuter Lange, S & Staff, K 2019, International biosimilar medicines review of the literature: quarterly update July 2019 - September 2019, GBMA Education, Australia. Open access
2019	Ward, M, Reuter Lange, S & Staff, K 2019, International biosimilar medicines review of the literature: quarterly update June 2018 - September 2018, GBMA Education, Australia. Open access
2018	Ward, M, Reuter Lange, S & Staff, K 2018, International biosimilar medicines review of the literature: quarterly update October 2018 - December 2018, GBMA Education, Australia. Open access
2018	Ward, M, Reuter Lange, S & Staff, K 2018, Literature review of international biosimilar medicines: update December 2017 - February 2018, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2018	Ward, M, Reuter Lange, S & Staff, K 2018, Literature review of international biosimilar medicines: update March - May 2018, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2017	Ward, M, Reuter Lange, S & Staff, K 2017, Literature review of international biosimilar medicines: update December 2016 - March 2017, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2017	Ward, M, Reuter Lange, S & Staff, K 2017, Literature review of international biosimilar medicines: update June - August 2017, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2017	Ward, M, Reuter Lange, S & Staff, K 2017, Literature review of international biosimilar medicines: update March - May 2017, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2017	Ward, M, Reuter Lange, S & Staff, K 2017, Literature review of international biosimilar medicines: update September - November 2017, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2016	Ward, M, Reuter Lange, S & Staff, K 2016, Literature review of International Biosimilar Medicines: Update June - September 2016, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2016	Ward, M, Reuter Lange, S & Staff, K 2016, Literature review of international biosimilar medicines, Commonwealth of Australia as represented by the Department of Health, Australia. Open access
2016	Ward, M, Reuter Lange, S & Staff, K 2016, Literature review of international biosimilar medicines: update September - December 2016, Commonwealth of Australia as represented by the Department of Health, Australia. Open access

External engagement & recognition

Collaborations

Highlights

Stephanie is a strong advocate for the importance of engagement and scientific communication to facilitate higher rates of research translation. She makes it a priority to engage end-users throughout the research process to maximise research outcomes and contribute significantly to health research within Australia and internationally. Stephanie also contributes widely to both the scientific and general communities through her involvement on a number of professional committees, dissemination of research findings to the public and promotion of careers in science. In acknowledgment of her scientific engagement and research significance, she has been awarded a Tall Poppy Award and two SA Science Excellence Awards.

External engagement & recognition

Collaborations

Organisation	Country
ASST Fatebenefratelli Sacco University Hospital	ITALY
Bod Australia Pty Ltd.	AUSTRALIA
Centre for Health Studies	LUXEMBOURG
Christian Medical College	INDIA
CMAX	AUSTRALIA
Concord Repatriation General Hospital	AUSTRALIA
CPR Pharma Services Pty Ltd	AUSTRALIA
Drugs for Neglected Diseases initiative (DNDI)	SWITZERLAND
Erasmus MC, Rotterdam	NETHERLANDS
Flinders Medical Centre	AUSTRALIA
Fondazione IRCCS Policlinico San Matteo	ITALY
Ghent University	BELGIUM
Hospital for Tropical Disease	THAILAND
Hunter Pathology	AUSTRALIA
Medicines for Malaria Venture	SWITZERLAND
Monash University	AUSTRALIA
Ohio State University	UNITED STATES
Pediatrix Screening	UNITED STATES
Pfizer Australia Pty Ltd	AUSTRALIA
Prince of Wales Hospital	AUSTRALIA
Princess Alexandra Hospital	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Q-Pharm	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal North Shore Hospital	AUSTRALIA
Sigma-Tau Industrie Farmaceutiche Riunite	ITALY
St Vincent’s Hospital	AUSTRALIA
St Vincents Hospital	UNITED STATES
St Vincent's Hospital	AUSTRALIA
St Vincents Hospital Sydney	AUSTRALIA
Swiss BioQuant	SWITZERLAND
Sydney Medical School	AUSTRALIA
Taylor's University	MALAYSIA
TetraQ	AUSTRALIA
The University of Notre Dame Australia	AUSTRALIA
University Hospital of Ghent	BELGIUM
University of Cape Town	SOUTH AFRICA
University of Groningen	NETHERLANDS
University of Hamburg	GERMANY
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Oxford	UNITED KINGDOM
University of Science, Malaysia	MALAYSIA
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Sydney	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Wollongong	AUSTRALIA
Utrecht University	NETHERLANDS
Van Giersbergen Consulting	FRANCE
Westmead Hospital	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
World Bank	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Bellberry Human Research Ethics Committee Bellberry Human Research Ethics Committee	2017
President Australasian Pharmaceutical Science Association (APSA)	2017
Finalist, Tall Poppy Award Australian Institute of Policy and Science	2014
Peoples Choice, SA Science Excellence Awards Department of State Development, Government of South Australia	2014
Early Career Fellowship National Health and Medical Research Council (NHMRC)	2013
Fulbright Visiting Researcher Scholarship Australian-American Fulbright Commission	2012
PhD Research Excellence Award, Health and Medical Science Department of State Development, Government of South Australia	2012

Teaching & student supervision

Teaching strengths

Physiology
Pharmacology
Pharmacokinetics
Biostatistics

Highlights

As a research-focussed academic, Stephanie values the opportunity to contribute to undergraduate teaching of physiology and pharmacology. She recognises the importance of these core subjects and aims to produce students with a sound body of knowledge that forms the foundation of their subsequent learning. Stephanie also has an interest in the teaching of biostatistics, specifically removing the stigma associated with this complex topic and providing education in a manner that is more accessible and usable for all researchers.

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Application of pharmacokinetic modelling to develop a dosing decision support tool to optimise vancomycin dosing in practice	Current
Optimising treatment of haematological malignancies through the development of evidence-based dose individualisation strategies	Current
Validate and optimization of Aminoglycoside Therapeutic Drug Monitoring in children and adults.	Current
Liquid chromatography-tandem mass spectrometry-based bioanalysis to assess toxicological and therapeutic aspects in human disease conditions	Completed
Pharmacometric methodologies and their use for lenalidomide drug development in chronic lymphocytic leukaemia	Completed

more less

Associate Professor Stephanie Reuter Lange

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Highlights

Projects

Outputs

Journal Articles

Reports

Current research & highlights

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Bellberry Human Research Ethics Committee

President

Finalist, Tall Poppy Award

Peoples Choice, SA Science Excellence Awards

Early Career Fellowship

Fulbright Visiting Researcher Scholarship

PhD Research Excellence Award, Health and Medical Science

Teaching & student supervision

Teaching strengths

Highlights

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

Gallery